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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 2 (2011) - Issue 12, December

Review Articles

 
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1.

FAST DISINTEGRATING TABLET TECHNOLOGY: NEWLY PROSPECTS

Tablet that disintegrate rapidly in the mouth are convenient for patient who have difficulty in swallowing conventional dosages forms. Although various formulation technologies like Zydis Technology, Durasolve Technology, Orasolve Technology, Flash Dose Technology, Wow Tab Technology, Flash Tab Technology, Quicksolv Technology, Lyos Technology, Fast Melt Technology and Zip-lets Technology are used...

A.K. Chaturvedi and A. Verma*

Department of Pharmaceutical Sciences, Faculty of Health & Medical Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences- Deemed to be University, Allahabad, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3046-50

3046-3050

2585

770

2.

A REVIEW ON HERBAL PLANTS SHOWING ANTIDEPRESSANT ACTIVITY

Depression is a heterogenous mood disorder that has been classified and treated in variety of ways. Although a number of synthetic drugs are being used as standard treatment for clinically depressed patient, they have adverse effects that can compromise the therapeutic treatment .Thus, it is worthwhile to look for antidepressant from plants with proven advantage and favorable benefit to risk ratio...

Talha Jawaid*, Roli Gupta and Zohaib Ahmed Siddiqui

Hygia Institute of Pharmaceutical Education and Research, Lucknow, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3051-60

3051-3060

9922

1772

3.

FREEZE DRYING PROCESS: A REVIEW

Among the various methods of drying, this article has mentioned only one most important method, “Freeze drying”. This method is mainly used for the drying of thermo labile materials. This method works on the principle of sublimation.  This method is divided into 3 steps for its better understanding; these are Freezing, Primary drying, and secondary drying. There are many advantages and disadv...

Soham Shukla*

Department of Pharmaceutical Technology, B. S. Patel Pharmacy College, Saffrony Institute of Technology, Near Saffrony Holiday Resort, Ahmedabad-Mehsana Highway, At & Post Linch-384435, Mahesana, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3061-68

3061-3068

14600

2296

4.

MICROSPONGE DELIVERY SYSTEM (MDS): A UNIQUE TECHNOLOGY FOR DELIVERY OF ACTIVE INGREDIENTS

In pharmaceutical industry, various controlled released dosage forms like solid formulation, semi solid formulation and topical preparation have more importance due to efficacy and patient compliance. Topical preparations have some disadvantages like unpleasant odour, greasiness and skin irritation and fail to reach the systemic circulation in sufficient amounts in few cases. This problem is overc...

Saurabh Kumar*, L.K. Tyagi, and Dashrath Singh

Department of Pharmacy, Institute of Bio-medical Education and Research, Mangalayatan University, Aligarh, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3069-80

3069-3080

3023

737

Research Articles

 
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5.

PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF ARTEMISIA PALLENS

Artemisia pallens Walls. ex DC, commonly known as Davana, is an aromatic herb found abundantly in humid habitats in the plains all over India. Artemisia pallens is found in Nilgiri hills, and has been used by the tribal people for various ailments. It has been widely used in Indian folk medicine for the treatment of diabetes mellitus. This plant is accredited with antihelmintic, antipyretic and to...

J. Suresh, A. Singh*, A. Vasavi, M. Ihsanullah and S. Mary

Department of Pharmacognosy, JSS College of Pharmacy, JSS University, SS Nagar, Mysore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3081-90

3081-3090

2842

1146

6.

ANTIMICROBIAL SCREENING AND BRINE SHRIMP LETHALITY BIOASSAY OF TINOSPORA CORDIFOLIA (FAM: MENISPERMACEAE)

Tinospora cordifolia (Fam: Menispermaceae) has been investigated for evaluation of the biological activities. The stem of Tinospora cordifolia were extracted with carbon tetrachloride, n-hexane and methanol were collected and afford 4.0 mg, 4.0 mg, and 4.0 mg, respectively for the test. The crude carbon tetrachloride, n-hexane, and methanol extract of the plant were subjected to antimicrobial scre...

Mohammad Kaisarul Islam* and Khondaker Ashakin

Department of Pharmaceutical & Biological Chemistry, School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3091-95

3091-3095

1539

456

7.

RESPONSES OR EFFECT OF CEREBRAL MALARIA ON PLATELET COUNT, PLATELET FACTOR – 3 AND PLATELET AGGREGATE AVAILABILITY IN CHILDREN

Background and Objective: Malaria, a formidable global parasitic infection represent a major health problem in tropical countries in terms of geographical spread, high morbidity, severe mortality especially among children. This study investigated platelet function’s role and its strength to make platelet factor 3 (PF-3) available for coagulation in children with cerebral malaria. Subjects and...

S. J. Ogboi *, S. P. Akpalu , I. A. Joshua and P.U. Agu

Public Health Laboratory, Department of Community Medicine, Faculty of Medicine, Ahmadu Bello University, Zaria, Kaduna State, Nigeria or Department of Life Sciences (Experimental Medicine MCA) and Public Health, University of Camerino, Via Madona Delle Carceri, 62032Camerino (MC) Italy

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3096-99

3096-3099

1401

545

8.

FORMULATION DESIGN AND OPTIMIZATION OF PULSATILE RELEASE TABLET OF ACEBROPHYLLINE WITH SWELLING AND ERODIABLE LAYERS FOR TREATMENT OF NOCTURNAL BRONCHIAL ASTHMA

Acebrophylline is a bronchodilator with mucosecrytolytic and anti-inflammatory activity. It is used to treat the bronchial asthma, and chronic obstructive pulmonary diseases. This work is based on the formulation and optimization of time dependant pulsatile release tablets of Acebrophylline having adequate mechanical strength of tablet and proper drug release of tablet. Pulsatile drug delivery sys...

Mohit D. Bauskar*, S.Y. Nandedkar, Rajendra D. Wagh

A. R. Ajmera College of Pharmacy, Dhule- 424005, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3100-08

3100-3108

1595

615

9.

EFFECT OF FRUIT JUICE ON THE DISSOLUTION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRIX TABLETS

In vitro dissolution of ten brands of diclofenac sodium sustained release matrix tablets were studied to determine the effect of fruit juice in the bioavailability of diclofenac. Significant reduction was observed in the release rate at all collected brands, where except sample D7 and D8 others were not fulfill the USP in vitro dissolution specification when administered with fruit juice. Therefor...

Mycal Dutta , Aninda Kumar Nath , Md Zia Uddin Md Akbar Hossain Md. Masud Morshed and Md. Hassan Kawsar*

Associate Professor, Department of Pharmacy, Dhaka International University, Dhaka-1213, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3109-13

3109-3113

2501

773

10.

A STUDY TO EVALUATE THE PERCEPTION OF PHARMACY STUDENT’S TOWARDS THE PHARMACY PROFESSION

The quality of education offered by Pharmacy institutions in the country varies widely. There are only a few institutions which maintain internationally recognized standard. A survey was conducted on the one hundred and twenty four (124) undergraduate Pharmacy students to determine their awareness and inclination towards Pharmacy as a career choice. Students were evaluated for the perception on th...

Yogesh Joshi* and Reena Pant

Himalayan Institute of Pharmacy & Research, Rajawala, Dehradun, Uttarakhand, India

DOI: 1http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3114-17

3114-3117

1858

479

11.

THROMBOLYTIC & CYTOTOXIC EFFECT OF DIFFERENT HERBAL EXTRACTS

An in-vitro thrombolytic model was used to check the clot lysis effect of four herbal extracts viz., Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens along with Streptokinase as a positive control and water as a negative control. And also brine shrimp lethality bio-assay was done using brine shrimp Nauplii ...

Md. Sheikh Anwar , Irfan Newaz Khan, Md. Mominul Islam Sarkar , Sabuj Barua , A. T. M. Mostafa Kamal , S M. Zahid Hosen

Assistant Professor, Department of Pharmacy, University of Science & Technology Chittagong (USTC), Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3118-21

3118-3121

2874

595

12.

PREVALENCE AND SUSCEPTIBILITY PATTERN OF E. COLI IN LOW BIRTH WEIGHT NEONATES OF EARLY ONSET SEPSIS

Neonatal sepsis is one of the commonest cause of neonatal mortality in the developing world which can be classified into early onset sepsis (EOS) which occurs in the first 7 days of life and late onset sepsis (LOS) which occurs ≥7 days of life. E. coli has been reported to be one of the significant and most common nosocomial pathogen which may cause septicemia, pneumonia and meningitis in the ne...

R. Singh*, S. Singh , S. P. Singh and D. Sachan

Assistant Professor, Department of Pharmacology, Shri Ram Murti Smarak Institute of Medical Sciences (SRMSIMS), Bareilly, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3122-28

3122-3128

1548

473

13.

COMPARATIVE IN VITRO DISSOLUTION STUDY OF SOME CIPROFLOXACIN GENERIC TABLETS UNDER BIOWAIVER CONDITIONS BY RP-HPLC

This study is aimed to assess the bioequivalence of five generic ciprofloxacin tablets from different manufacturer using in vitro dissolution study under biowaiver conditions by RP-HPLC. Dissolution media were USP buffer solutions at pH 1.2 (hydrochloric acid solution), pH 4.5 (acetate buffer solution), and pH 6.8 (phosphate buffer solution). Other general quality assessment tests of these tablets...

Tanjinatus Shams Oishi, Md. Ahsanul Haque, Irin Dewan, and S. M. Ashraful Islam*

Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3129-35

3129-3135

4153

2095

14.

EFFECT OF PROCESSING AND POLYMER VARIABLES ON INVITRO RELEASE OF METOPROLOL SUCCINATE EXTENDED RELEASE TABLETS

The present study was aimed to develop an extended release tablet of Metoprolol Succinate for the treatment of hypertension. Four extended release formulations F1-F4 were developed using varying proportions of Hydroxyl propyl methyl cellulose K100M, Sodium carboxy methyl cellulose and Eudragit L30 D55 by wet granulation. Five extended release formulations F5-F9 containing HPMC K100M and HPMC 5cps ...

N. N. Rajendran*, R. Natarajan and T. Sakthikumar

Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengodu, Namakkal – 637205, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3136-42

3136-3142

1675

444

15.

SYNTHESIS, SPECTROSCOPIC, THERMAL STUDIES AND BIOLOGICAL ACTIVITY OF A NEW SULFAMETHOXAZOLE SCHIFF BASE AND ITS COPPER COMPLEXES

A new Sulfamethoxazole Schiff base (E)-4-(4-methoxybenzylideneamino)-N-(5-methylis-oxazol-3-yl) benzenesulfonamide (C18H17N3O4S), and its copper complex were synthesized and the structures elucidated on the basis of Physiochemical methods. The studies indicate an octahedral structure for the complexes with the (C22H27N3O10SCu) formula. The IR spectra suggest that the ligand act as tridentate (from...

M. A. El-Nawawy, R. S. Farag, I. A. Sabbah, and A. M. Abu-Yamin*

Department of Chemistry, Faculty of Science Al-Azhar University, Cairo, Egypt

DOI: ://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3143-48

3143-3148

1919

706

16.

SIMULTANEOUS ESTIMATION OF CETRIZINE DIHYDROCHLORIDE AND AMBROXOL HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION BY A NOVEL HPLC METHOD

A rapid and sensitive high performance liquid chromatography method for determination of cetirizine dihydrochloride and ambroxol hydrochloride has been developed. The chromatography system used a reversed phase C-8 column with UV- Vis detection at 230 nm. Mobile phase consisted of acetonitrile – 0.1% triethlamine (50:50 v/v) (pH adjusted to 4.0 using 10% ortho phosphoric acid) at a flow rate of ...

Pragi Arora*, Varun Arora and Sandeep Jain

Associate Professor, R.K.S.D. College of Pharmacy, Kaithal- 136027, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3149-51

3149-3151

1519

395

17.

NUTRITIONAL QUALITY OF SOME CULTIVATED AND WILD SPECIES OF AMARANTHUS L.

Amaranthus vegetable and seeds are highly nutritious. Four species of Amaranthus were planted in pots in a glass house and leaves were harvested. Fresh leaves were analyzed for protein and carbohydrate content and oven dried leaves for Fe, Ca, K and Na contents. Protein content was varied from 6.10-9.00g/100g of fresh leaves. The amount of carbohydrate in fresh leaves of all four species varied fr...

Reema Srivastava

Laboratory of Cytogenetics, Center of Advanced Study in Botany, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3152-56

3152-3156

1936

574

18.

SYNTHESIS AND BIOEVALUATION OF KETOCONAZOLE THIOSEMICARBAZONE ANALOGUES

Ketoconazole (KTZ) is a synthetic antifungal drug used to prevent and treat fungal infections, especially in immunocompromised patients such as those with AIDS. Resistance to ketoconazole has been observed in a number of clinical fungal isolates, including C. albicans. Thus new effective agents with less toxicity against fungal infection are urgently required. With this view, ketoconazole thiosemi...

T. K. Agrawal and Y. Murti*

Assistant Professor (Pharmaceutical Chemistry), Institute of Pharmaceutical Research, GLA University, Mathura, 17, Km Stone, National Highway #2, Delhi-Mathura Road, P.O. Chaumuha, Mathura-281406, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3157-60

3157-3160

2937

618

19.

ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF THE DIFFERENT FRACTIONS OF METHANOLIC EXTRACTS OF ENTADA PHASEOLOIDES (L.) MERR. IN ALLOXAN INDUCED DIABETIC MICE

The antidiabetic effects of Ethyl acetate (Et Ac), Petroleum-ether (Pet ether), and Chloroform fractions from methanolic extract of the seeds of Entada phaseoloides were investigated in alloxan induced diabetic mice (AIDM). The effect of these fractions (200 mg/kg body weight i.p) was observed on fasting blood glucose (FBG) level and active fraction was further investigated for its dose dependent ...

Md. Ikram, Z. M. Babar, A. M. Taufiqual Islam, M. A. Uddin Chowdhury, M. E. Uddin, Md. Rafikul Islam and M. Saiful Islam*

Department of Pharmacy, International Islamic University Chittagong, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3161-65

3161-3165

1651

538

20.

ESSENTIAL OIL COMPOSITION AND ANTIMICROBIAL SCREENING OF LAUNAEA NUDICAULIS GROWN IN OMAN

The essential oil of the aerial parts of Launaea nudicaulis was isolated using Clevenger's apparatus and analyzed by GC/MS instrument. Different extracts of the aerial parts of Launaea nudicaulis were tested for their activity against Staphylococcus aureus and Escherichia coli. Seventeen constituents were identified in the essential oil. The major constituents in the essential oil are limonene, Z-...

Jamila A. Al-Mahrezi , Jamal Nasser Al-Sabahi , Mohammed Sohail Akhtar , Dina Selim and Afaf Mohammed Weli*

ABSTRACT Correspondence to Author: Afaf Mohammed Weli 33, Pc 616, Birkat AL Mouz, Nizwa University, School of Pharmacy, Nizwa, Sultanate of Oman

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3166-69

3166-3169

1865

872

21.

IN-VITRO ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL STUDIES OF BOERHAAVIA DIFFUSA LINN. ROOTS.

The present study was carried out to evaluate the antioxidant activity and phytochemical constituents of Boerhaavia diffusa Linn. (Nyctaginaceae) dried roots. The root extracts were prepared with chloroform, ethanol and water and screened for in vitro antioxidant activities by using assay of DPPH radical scavenging, antiproteolytic activity, polyphenol oxidase inhibition, hydroperoxide inhibition ...

K. S. Shisode* and B. M. Kareppa

Department of Biotechnology, D.S.M. College, Parbhani- 431401, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3170-76

3170-3176

1749

647

22.

ROLE OF SOLVENT ACCESSIBLE SURFACE AREA (ASA+) AND BALABEN 3D INDEX (J3D) IN BINDING AFFINITY OF TIBO DERIVATIVES

In present QSAR study of TIBO derivatives, aim of the author is to analysis some different 3D parameter in order to get best QSAR model, which enhance the binding affinity of TIBO derivatives. Solvent accessible surface area (3D) of all atoms with positive partial charge (strictly greater than 0) and Balaben 3D index plays vital role in this concern. This study focuses on some important and differ...

Lokendra Kumar Ojha*, Ajay M. Chaturvedi and Arpan Bhardwaj

Department of Chemistry, Government Madhav Science PG College, Ujjain, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3177-82

3177-3182

1292

402

23.

ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF LAWSONIA INERMIS

The leaf of the plant Lawsonia inermis was examined for analgesic and anti-diarrhoeal properties. From the study of analgesic activity it was found that ethanol extract at a dose of 500 mg/kg exhibited no significant (p<0.3) inhibition of writhing reflex (28.45 % inhibition) while the inhibition of standard drug diclofenac sodium showed 82.7 % inhibition at a dose of 25 mg/kg body weight. The f...

Saki Sultana * and K. Hasan Khosru

Lecturer, Department of Pharmacy, BRAC University, Dhaka-1212, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3183-88

3183-3188

1325

443

24.

ANALYTICAL CHARACTERIZATION OF A CONTROLLED RELEASE POLYMERIC SUSPENSION

Aims: Qualitative analysis of a mucoadhesive polymeric (Carbopol940) suspension of Norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. Methods: The characterization of ultrasonicated formulation was performed by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, X-ray powder diffraction (XRD) and Scanning electron micr...

Subhashree Sahoo*, Chandra Kanti Chakraborti , Pradipta Kumar Behera and Subash Chandra Mishra

Associate Professor, Department of Pharmaceutics, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela – 769015, Orissa, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3189-01

3189-3201

1401

364

25.

DEVELOPMENT AND VALIDATION OF TWO SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF METRONIDAZOLE AND OFLOXACIN IN SUSPENSION

Two simple, sensitive, rapid, accurate and economical methods were developed for the estimation of Metronidazole and Ofloxacin in two component liquid dosage form. First method is based on the simultaneous equation and second method is based on Q-analysis (absorbance ratio method). Metronidazole has absorbance maxima at 318.0 nm and Ofloxacin has absorbance maxima at 294 nm in acetonitrile and dil...

Nirav B Patel* Alpesh C. Aravdiya and Hemant T. Desai

Nirlife Healthcare (Healthcare Division of Nirma), Sachana- 382150, Ahmadabad, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3202-06

3202-3206

1707

410

26.

IN- VITRO ANTIOXIDANT ACTIVITY OF HYDROETHANOLIC EXTRACT OF STEM BARK OF OUGEINIA OOJEINENSIS (ROXB.) HOCHR (LEGUMINOSAE)

Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. In this study, the antioxidant activity of hydroethanolic extract of stem bark of Ougeinia oojeinensis (Roxb.) (HEBO) was studied using various in vitro assays. The antioxidant activity of the extract was evaluated by using the free radical scavenging activity assay (DPPH...

P. P. Shinde*, Y. M. Joshi and V. J. Kadam

Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, Sector 8, CBD, Belapur, Navi Mumbai - 400614, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3207-09

3207-3209

1376

520

27.

COMPARATIVE ASSESSMENT OF THE PHYSICOCHEMICAL AND IN-VITRO BIOAVAILABILITY EQUIVALENCE OF CO-TRIMOXAZOLE TABLETS MARKETED IN TIGRAY, ETHIOPIA

The availability of numerous brands of co-trimoxazole in our local market today places health professionals in a difficult situation of choice of a suitable brand or the possibility of alternative use. The aim of the study was to predict the physicochemical and in-vitro bioavailability equivalence of six brands of co-trimoxazole tablets marketed in Tigray, Ethiopia. Weight uniformity, friability, ...

Gebremedhin Solomon Hailu*, Girma Belachew Gutema, Adissu Alemayehu Asefaw, Dagim Ali Hussen and Mussie Ghezu Hadera

Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle 1871, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3210-18

3210-3218

2222

1312

28.

PHARMACOGNOSTIC AND PRELIMINARY PHYTOCHEMICAL EVALUATION OF THE LEAVES OF CRINUM LATIFOLIUM L.

Crinum latifolium L. is a rosette-like herb showing promising results as rubefacient, tonic, for treatment of allergic disorders, benign prostatic hyperplasia, cancer and others. The present study deals with pharmacognostic and preliminary phytochemical evaluation of leaves of Crinum latifolium (Amaryllidaceae). The pharmacognostical studies were carried out as organoleptic, microscopic and physic...

J. Solanki*, A. Dhiman , A. Nanda and A. Dhankhar

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3219-23

3219-3223

2454

832

29.

PHYTOCHEMICAL EVALUATION AND ANTIMICROBIAL ACTIVITY OF ETHANOLIC EXTRACT OF VISMIA GUIANENSIS (AUBL.) CHOISY

Studies have been demonstrating that Vismia guianensis (Aubl.) Choisy, popularly known as seal, a species native to South America has high anticancer and antimicrobial potential. The objective of this study was to evaluate the antimicrobial activity of the ethanolic extract obtained from the leaves of V. guianensis, and trace its chemical profile. The phytochemical screening showed the presence of...

Sarah Regina Pereira Camelo , Russany Silva Costa , Roseane Maria Ribeiro-Costa , Wagner Luiz Ramos Barbosa , Flavio Vasconcelos , Jose Maria dos Santos Vieira and Jose Otavio Carrera Silva Junior*

Adj. Prof., School of Pharmacy, Federal University of Para, University City, “Jose da Silveira Netto”, CEP 66075-110, Belem, Para, Brazil

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3224-29

3224-3229

1714

511

30.

EVALUATION OF ANTI-NOCICEPTIVE ACTIVITY AND BRINE SHRIMP LETHALITY BIOASSAY OF ROOTS OF LEEA MACROPHYLLA ROXB.

The ethanolic extracts and its different partitioning fractions of roots of Leea macrophylla (Leeaceae) were evaluated for their analgesic and preliminary cytotoxic activities. The analgesic activity was evaluated using the acetic acid-induced writhing test in mice while the screening of cytotoxic activity was done using brine shrimp lethality bioassay. In acetic- acid induced writhing test, the e...

Zobaer A. Mahmud , Sitesh C. Bachar and Nazmul Qais*

Professor and Chairman, Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Ramna, Dhaka-1000, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3230-34

3230-3234

1736

520

31.

EFFICACY OF AGERATUM CONYZOIDES AGAINST THE CONTROL OF MOSQUITOES

Mosquitoes transmit serious human diseases causing millions of deaths every year. Phytochemistry has proven that there are potential mosquito control agents and also alternatives to synthetic insecticides. The present paper reports Ageratum conyzoides commonly known as Kubhi in Hindi of family Astereacae. The plant after proper identification was collected shade dried and powdered to the fine mesh...

Neetu Arya*, Sangeeta Chaurasia, Anita Shakya, Matadeen Bharti and Neera Sahai

Pest control and Ayurvedic Drug Research Laboratory, S.S.L. Jain P. G. College, Vidisha, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3235-37

3235-3237

1813

543

32.

PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUTION OF VENTILAGO CALYCULATA

Ventilago calyculata (Rhamnaceae) commonly known as Pitti. Ventilago calyculata is present in hotter parts of India, Burma, Siam, China, in forest region. The plant is antimalarial, Antiviral, stomachic, skin disorder. Phytochemical studies had revealed the presence of flavonoids, triterpenoids, tannin, naphthoquinone, anthraquinone. Present study was carried out to determine, the morphological, m...

S. Yadav*, A. Joshi, K. Ahmed and B. K. Dubey

Department of Pharmacognosy, TIT-College of Pharmacy, Anand Nagar, Bhopal- 462021 Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3238-42

3238-3242

1691

462

33.

FORMULA OPTIMIZATION OF IMMEDIATE RELEASE TABLET OF CLOPIDOGREL BISULPHATE FREE FROM SURFACE IRREGULARITIES

Clopidogrel Bisulphate is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Immediate release tablet of clopidogrel bisulphate (form II) was prepared by using direct compression technique. Clopidogrel Bisulphate is very hygroscopic and show rapid degradation when processed with alkali s...

Hardik Jain, Vimal Arora , Jitendra Gupta and Anil Bhandari

M.Pharm (Research Scholar), Vpo-Nayagaon, Teh- Kherwara, Dist.- Udaipur, Rajasthan 313804, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3243-46

3243-3246

1769

960

34.

FORMULATION OF SYNBIOTIC DRINK TO ENHANCE INTESTINAL GUT FLORA

The transition in diet has lead to an increase in lifestyle disorders and thereby increased dependency on wonder drugs. With increased drug discovery and marketing, there is a compelling trend towards large drug dosage. However, food is judged not only for its nutritive properties but also for its ability to improve the health and well being of consumers, thus leading to the advent of “FUNCTIONA...

P. L. Sridevi Sivakami* and S. Subhashree

Department of Food Service Management and Dietetics, Avinashilingam Deemed University, Coimbatore-641 043, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3247-53

3247-3253

1734

527

35.

IMPROVED EFFICIENCY AND REDUCED COSTS DURING INFUSION THERAPY WITH PREMIXED PREPARATIONS COMPARED TO FREEZE-DRYING POWDER

Background: An excessive medical expenditure is becoming a main barrier to good health for several people in China. Hence, there is a need to control this rising medical cost to reduce the financial burden placed on family and society in general. Objective: Our aim was to understand the expenses incurred during the use of two forms of infusion therapy- the premixed preparations and the freeze-d...

Xin Zhou, Zhan-Miao Yi and Suo-Di Zhai*

Department of Pharmacy, Peking University, Third Hospital, Beijing 100191, P. R., China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3254-59

3254-3259

1692

514

36.

FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES USING VERAPAMIL HYDROCHLORIDE AS MODEL DRUG

The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of verapamil. Frequent administration and variable low bioavailability (40-60%) after oral administration are problems of conventional dosage forms of verapamil can be attenuated by designing it in the form of mucoadhesive...

Mahendra Singh* and Vinay Vijay

Lord’s International College of Pharmacy, Chikani, Alwar, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3260-68

3260-3268

2152

631

37.

ISOCRATIC RP-HPLC, UV METHOD DEVELOPMENT AND VALIDATION OF ITRACONAZOLE IN CAPSULE DOSAGE FORM

A simple, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed and validated for the estimation of Itraconazole in capsule dosage form. An inertsil C-18, 5μm column having 250 x 4.6mm internal diameter in isocratic mode with mobile phase containing Tetrabutyl ammonium hydrogen sulphate buffer solution and Acetonitrile in the ratio of 40:60v/v w...

M. V. Kumudhavalli*

Department of Pharmaceutical Analysis, Vinayaka Mission College of Pharmacy, Salem-636008, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3269-71

3269-3271

2942

969