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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 10 (2019) - Issue 11, November

Review Articles

 
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1.

POSSIBLE MECHANISMS OF METABOLIC CHANGES OF BIOCHEMICAL METABOLISM IN THE CONDITIONS OF EXPERIMENTAL ALLOXAN-INDUCED DIABETES MELLITUS (DM)

Alloxan diabetes mellitus (DM) simulates acute metabolic stress in a different direction, whose starting point is primary lysis of β-cells in the pancreas. Disorders in the system of the major insulin-induced regulatory mechanism occur, initiating imbalance in the system of a living organism generally. Primary changes occur on the level of metabolic ways of the cells of the pancreas and liver: re...

O. G. Chernyukh *, M. V. Dikal and V. Gerushi

Department of Bioorganic and Biological Chemistry and Clinical Biochemistry, Bukovinian State Medical University, Ukraine.

DOI: 10.13040/IJPSR.0975-8232.10(11).4806-17

4806-4817

428

398

2.

DENTAL CARIES AND LACTOBACILLUS: ROLE AND ECOLOGY IN THE ORAL CAVITY

Dental caries is an infective serious transmittable bacterial disease characterized by a multi-factorial pathology. Main players in the etiology of this disease are cariogenic bacteria, fermentable carbohydrates, a susceptible tooth, the host, and the time. It is still one of the most common disease worldwide. Biological factor such as cariogenic bacteria plays an important role in dental caries i...

S. S. Ahirwar, M. K. Gupta and S. K. Snehi *

Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4818-29

4818-4829

443

198

3.

A COMPLETE GUIDE ON THE PHARMACOLOGIC AND PHARMACOTHERAPEUTIC ASPECTS OF CALCIUM CHANNEL BLOCKERS: AN EXTENSIVE REVIEW

The calcium channel blockers, a diverse group of cardiovascular drugs, exert their action by inhibiting the L-type calcium channels and cause vasodilatation in the heart and the smooth muscles. They also block the action potential at the SA and AV node, thus prolonging the duration of the action potential (Verapamil and Diltiazem). Although, the calcium channel blockers have the same anti-hyperten...

S. Kishor

PSG College of Pharmacy, Peelamedu, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4830-43

4830-4843

266

164

4.

HISTORY, MANIFESTATION AND PREVENTIVE MEASURES FOR RUBELLA IN INDIA: A REVIEW

Rubella is an eradicable illness on the grounds of immunization against it produces solid protection. The name rubella comes from the Latin language, and it means “little red”. In olden times people thought that rubella was a variant of measles. German literature first described it as a separate disease, and hence it was also called “German Measles”. People are the main reservoir of the in...

D. C. Sati and R. K. K. Arya *

Department of Pharmaceutical Sciences, Kumaun University, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4844-52

4844-4852

372

155

Research Articles

 
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5.

DETERMINATION AND APPLICATION OF BIORELEVANT DISSOLUTION MEDIA TO MEET THE IN-VIVO PERFORMANCE IN VALSARTAN AND CHLORTHALIDONE IN SOLID DOSAGE FORM

Dissolution testing with biorelevant media is used in the pharmaceutical industry as a predictive tool for the estimation of drug formulation’s in-vivo performance in bioequivalence studies. The objective of this study was to determine the biorelevant dissolution media enabling the prediction of in-vivo performance of Valsartan and Chlorthalidone in solid oral dosage form as new fixed drug combi...

S. Sarisan *, G. G. Kayar, M. Gokalp, U. K. Dude, Z. Knezevic, N. Dayan and C. Onal

Abdi Ibrahim Pharmaceuticals, Abdi Ibrahim Production Facilities, Esenyurt, Istanbul, Turkey.

DOI: 10.13040/IJPSR.0975-8232.10(11).4853-60

4853-4860

340

210

6.

POST TRAUMATIC STRESS DISORDER AND THE TOXICOLOGY OF CANNABIS SATIVA

Many young men, women, and even the elderly are addicted to Cannabis intake abuse despite its predictable toxicological consequences. In this paper, we studied the toxic effects of oral administration of methanol extract of Cannabis sativa seeds using a total of forty male Wistar Rats. Animals were randomized into five groups (n = 8 rats) of approximately equal weight. Group 1 received 100 mg/kg o...

O. O. Charles *, Y. N. Omeh, B. O. Onyemegbulem and J. C. Aguiyi

Michael Okpara University of Agriculture, Umudike, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.10(11).4861-67

4861-4867

417

140

7.

SCREENING OF ANTICANCER AND ANTI-OXIDANT ACTIVITY OF LEAVES OF ANNONA RETICULATA ON EAC INDUCED SOLID TUMOR

Objective: The objective of the study was to evaluate the in-vivo anticancer and antioxidant activity of methanolic extract of leaves of Annona reticulata Linn. on EAC induced solid tumor. Methodology: Tumor cells (1 × 106 cells/mice/I.M.) were injected into the hind limb for solid tumor formation, and the treatment started from day 1 for 14 days. Group 1 served as a Normal control, Group 2 serve...

P. K. M. Nagarathna, K. Yadav *, D. M. M. Lou and G. T. Bhutia

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4868-80

4868-4880

363

202

8.

DEVELOPMENT AND VALIDATION OF A SENSITIVE AND SPECIFIC HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR ASSAY OF A BINARY MIXTURE OF PANTOPRAZOLE AND DOMPERIDONE IN ORAL SOLID DOSAGE FORMULATIONS

A simple new rapid, accurate, robust, and specific HPLC method was developed for the assay of pantoprazole and domperidone from the oral solid dosage pharmaceutical formulations. The reverse-phase chromatographic method was developed on an RP C8 column (250 mm × 4.6 mm, 5 µm) using a mixture of 25 mM sodium dihydrogen phosphate solution of pH 6.8 and methanol in the ratio 40:60 v/v as mobile pha...

A. Basu and J. Chakraborty *

CSIR Central Glass and Ceramics Research Institute, Jadavpur, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4881-88

4881-4888

264

172

9.

PHARMACOLOGICAL POTENTIAL OF POLYHERBAL COMBINATION FOR THE TREATMENT OF GLOMERULONEPHRITIS IN ALBINO RATS

The polyherbal combination was prepared by using aqueous and methanol root extracts of A. officinalis, B. diffusa, C. papaya, C. fistula, C. intybus, F. hispida, F. indica, C. nurvala, S. virgaurea and V. negundo in equal proportion for the dose of 25 mg/kg and 50 mg/kg body weight. Albino Wistar rats were selected for the study; the serum uric acid, urea, creatinine, BUN, and albumin level were m...

H. Maurya and T. Kumar *

Department of Pharmaceutical Sciences, Kumaun University, Bhimtal Campus, Bhimtal, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4889-98

4889-4898

280

158

10.

IDENTIFICATION AND QUANTIFICATION OF OLEANOLIC ACID FROM CYCLEA PELTATA BY HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHY (HPTLC) METHOD

Objective: To identify and quantify oleanolic acid from the roots of cyclea peltata by HPTLC method. Methods: The Plant cyclea peltata is a perennial herb from Menispermacae family. The powdered roots of plant cyclea peltata were extracted with methanol. Methanolic extract prepared separated with n-butanol, chloroform, and ethyl acetate as total saponin, total alkaloid and phenolic compound fracti...

L. B. Bhagure and H. D. Une *

Department of Pharmacology, Y. B. Chavan College of Pharmacy, Rouza Bagh, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4899-06

4899-4906

118

51

11.

QbD BASED RP-HPLC METHOD DEVELOPMENT FOR FIVE FLUOROQUINOLONE ANTI-BACTERIALS – THROUGH CREATION OF DESIGN SPACE FOR CRITICAL ATTRIBUTES

Quality by Design (QbD) has become an important concept for the pharmaceutical industry, and ICH recommends this concept through the Guideline Q8 (R2) wherein if the method is proved to be rugged and robust within the limits of a Design Space then approval may be requested for such a Design Space, and the method does not need redevelopment, revalidation, and reapproval during transfers, thereby sa...

S. S. Kudchadkar * and S. P. N. Pai

Department of Pharmaceutical Analysis, Goa College of Pharmacy, Panaji, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4907-12

4907-4912

134

45

12.

A STATISTICAL APPROACH TO THE DEVELOPMENT OF FAST DISINTEGRATING TABLETS OF TELMISARTAN USING CO-PROCESSED SUPERDISINTEGRANT

The present investigation deals with fast disintegrating tablets of the model drug (Telmisartan) and to determine the influence of the excipients on physical properties of tablets. Employing a Box Behnken design, concentration of co-processed superdisintegrants (Crosspovidone: sodium starch glycolate) (X1), the concentration of meglumine (X2) and concentration of sodium lauryl sulfate (X3), select...

S. C. Atram * and S. D. Pande

Vidyabharati College of Pharmacy, Amravati, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4913-21

4913-4921

111

59

13.

ANTIBACTERIAL, ANTIOXIDANT, CYTOTOXICITY AND QUALITATIVE PHYTO-CHEMICAL EVALUATION OF SEED EXTRACTS OF NIGELLA SATIVA AND ITS SILVER NANOPARTICLES

Nigella sativa is considered a miracle herb plant belongs to the Ranunculaceae family, inhabitant to South Asia and South-west Asia. The most important part of the Nigella sativa plant used by human beings are seeds, mostly as a spice because it contains a specific aroma. The seeds derived from Nigella sativa being exploited by people and used for thousands of years for culinary purposes, to cure ...

A. Kumar *, D. Singh, H. Rehman, N. R. Sharma and A. Mohan *

Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4922-31

4922-4931

136

72

14.

ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACTS OF ANACARDIUM OCCIDENTALE, AEGLE MARMELOS AND ACHYRANTHES ASPERA IN ALLOXAN-INDUCED DIABETIC RATS

Diabetes mellitus is a major endocrine metabolic disorder of multiple etiologies characterized by chronic hyperglycemia; with disturbances of carbohydrate, protein, and fat metabolism. It is caused by the deficiency or ineffective production of insulin by pancreas, which results in increase or decrease in concentrations of glucose in the blood. There is number of chemical agents available to contr...

Brijyog *, L. P. Singh, S. Kumar and S. Verma

Institute of Pharmacy, Harish Chandra P.G. College, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4932-36

4932-4936

103

59

15.

ISOLATION AND CHARACTERIZATION OF L-ASPARAGINASE EXTRACELLULAR ENZYME PRODUCING BACTERIA FROM INDUSTRIAL SOIL SAMPLES

Industrial soil contains a variety of L-Asparaginase producing microorganisms such as bacteria and fungi. Microorganisms can produce different types of enzymes which are frequently used in different types of industries for different purpose. In the present study, we focused on isolation of L-Asparaginase enzyme producing bacteria from industrial soil samples collected from different regions of Gwa...

R. S. Tomar, N. Sharma * and S. Kaushik

Amity Institute of Biotechnology, Amity University, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4937-41

4937-4941

144

56

16.

STUDIES ON ANTIMICROBIAL ACTIVITY OF ZIZIPHUS RUGOSA LAM. PERICARP

The desire of the present study was to investigate in-vitro antimicrobial activity on different crude extracts of Ziziphus rugosa pericarp. The antibacterial assay was carried out against Bacillus subtilis MTCC 1133, Staphylococcus aureus MTCC 7443, Escherichia coli MTCC 1692 and Salmonella typhi ATCC 19430. Meanwhile, Candida albicans ATCC 18804, Aspergillus niger ATCC 16404, Trichoderma harzianu...

G. Prema *, M. Chitra and R. Kanagasabai

PG and Research Department of Botany, Government Arts College, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4942-48

4942-4948

282

88

17.

STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PANTOPRAZOLE AND LEVOSULPIRIDE IN PHARMACEUTICAL DOSAGE FORM

Simple, sensitive, and rapid stability indicating RP-HPLC method for simultaneous estimation of Pantoprazole and Levosulpiride in pharmaceutical dosage form was developed and validated. The analysis was carried out on Hibar C18 column (250 × 4.6 mm, id, 5µ) and the mobile phase composition was 10 mM ammonium acetate (pH 4.0 adjusted using acetic acid): Acetonitrile in the ratio of 20:80% v/v wit...

N. H. Shivaraju, G. Kowmudi, K. Anoop and K. Nagappan *

Department of Pharmaceutical Analysis, JSS College of Pharmacy, [A Constituent College – JSS Academy of Higher Education & Research] Udhagamandalam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4949-58

4949-4958

213

52

18.

NEUROLOGICAL, HAEMATOLOGICAL AND HISTOLOGICAL EFFECTS OF CHRONIC EXPOSURE TO NITROUS OXIDE IN WISTAR ALBINO RATS

Objectives: The objectives of the study were to investigate the neurological, hematological, and histological effects of chronic exposure to nitrous oxide (N2O) in male Wistar albino rats. Methodology: 12 adults, male, Wistar albino rats (150-200g) were divided into 2 groups of 6 animals each. Group 1 served as control. Group 2 received N2O + O2 (70:30 mixture) for 1 h every day for 60 days. Neuro...

K. Neevedha, R. Arunkumar *, A. Ruckmani, V. Meti and K. Lavanya

Department of Pharmacology, Chettinad Hospital & Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4959-67

4959-4967

117

46

19.

A NOVEL STABILITY INDICATING UPLC METHOD FOR THE ESTIMATION OF TEZACAFTOR AND IVACAFTOR IN TABLET DOSAGE FORM

UPLC is a modern technique which refers to Ultra Performance Liquid Chromatography and enhances in three main areas: Speed, resolution, and sensitivity. In this present study, an accurate and precise UPLC method was developed and validated for the stability indicating assay method to estimate Tezacaftor and Ivacaftor simultaneously in both bulk and tablet dosage form. This method was developed usi...

Shyamala * and D. Ashok

Department of Pharmaceutical Sciences, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4968-73

4968-4973

114

55

20.

ASSESSMENT OF REPRODUCTIVE TOXICITY OF CONCOCTION OF ANDROGRAPHIS PANICULATA IN MALE WISTAR ALBINO RATS

Objective: To assess the reproductive toxicity of concoction of Andrographis paniculata in male Wistar albino rats. Methods: 18 male Wistar albino rats were divided into 3 groups with 6 animals in each group. Group 1 served as control and received distilled water. Group 2 and 3 received 0.5 ml of a concoction of Andrographis paniculata and Nilavembu kudineer (a concoction of 9 herbs) respectively ...

R. M. Kumar, R. Arunkumar *, A. Ruckmani, K. Lakshmipriya, V. Meti, V. Vivek, E. Abinaya and A. N. Nisha

Department of Pharmacology, Chettinad Hospital & Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4974-80

4974-4980

108

48

21.

DEVELOPMENT AND VALIDATION OF A NEW RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF ANTIRETROVIRAL DRUGS: COBICISTAT AND ELVITEGRAVIR

A simple, precise, rapid and accurate reverse phase HPLC method was developed for the simultaneous estimation of cobicistat and elvitegravir in the pharmaceutical dosage form. A column of ODS (250mm 4.6mm; i.d and 5µ particle size) was used along with the mobile phase comprising of 0.02M dipotassium hydrogen orthophosphate buffer (pH adjusted to 3.3) and methanol in the ratio of 80:20 (v/v). The...

B. M. S. Kumar *, B. Rajkamal, D. V. R. N. Bhikshapathi and T. Padmini

Mewar University, Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4981-87

4981-4987

115

65

22.

THE POTENTIAL PROTECTIVE EFFECT OF ROASTED DATE PALM CAKE EXTRACTS (PHOENIX DACTYLIFERA L.) AGAINST NICKEL CHLORIDE-INDUCED INFERTILITY IN MALE MICE

The powder date palm cake is sold in coffee and confectionary shops in the central region of the Kingdom of Saudi Arabia, where it is used as a hot drink in the form of decoction. It is alleged by users in the local community in Saudi Arabia to improve fertility. The date palm cake is the roasted grounded seeds of the date palm (Phoenix dactylifera L.). The objective of this study is to evaluate t...

S. E. M. Eltom *, M. A. Mobark, M. S. Al-Omer, H. A. Mohammed, E. M. E. Agabein, M. H. Alqambar and M. Alhawsawi

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, KSA.

DOI: 10.13040/IJPSR.0975-8232.10(11).4988-94

4988-4994

279

55

23.

SOLID DISPERSIONS OF FENOFIBRATE BY DROPPING METHOD

The main objective of the study was to enhance the dissolution of fenofibrate (BCS class II), poorly soluble drug. To improve the solubility of the drug, solid dispersions were prepared by dropping method with PEG 4000 and PEG 6000 in the ratios of 1:1 and 1:2. The formulations were filled into capsules and evaluated for solubility, assay, FTIR, X-ray diffractions, DSC, and in-vitro dissolution. T...

D. Prasanthi *, C. Prakash and K. L. Aishwarya

G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4995-01

4995-5001

211

57

24.

PREVALENCE OF ANEMIA AND ITS ASSOCIATED FACTORS AMONG PREGNANT WOMEN ATTENDING ANTENATAL CENTER IN SHARJAH, UAE

Anemia during pregnancy is a common complication which can involve a mother’s health, baby’s health, or both. Socioeconomic status is affecting the prevalence of maternal anemia, which is varied substantially across regions and countries. Although, the prevalence of maternal anemia in UAE has not yet been well documented nationwide. Therefore, knowledge of the prevalence and determinants of lo...

M. J. Shahwan *, N. A. Hassan and N. M. Sada

College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates.

DOI: 10.13040/IJPSR.0975-8232.10(11).5002-09

5002-5009

125

49

25.

STUDIES ON BIOCHEMICAL AND ANTIBACTERIAL ACTIVITIES OF THREE MEDICINALLY IMPORTANT FRUITS

Medicinal plants are essential in our balanced life diet and are in demand in allopathic and herbal medicine. The present study was aimed to evaluate the phytochemical, antioxidant and antimicrobial activities of Phyllanthus emblica (Euphorbiaceae), Averrhoa bilimbi (Oxalidaceae) and Phyllanthus acidus (Euphorbiaceae) fruits. The preliminary phytochemical analysis was carried out using standard me...

K. S. Ashalatha, S. Hemalatha and H. R. Raveesha *

Department of Botany, Jnana Bharathi Campus, Bangalore University, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5010-15

5010-5015

200

58

26.

IN-VITRO AND IN-VIVO ANIMAL MODEL FOR SCREENING ANTI-DIABETIC ACTIVITY OF HELLENIA SPECIOSA (J. KOENIG) S. R. DUTTA

Diabetes mellitus is one of the most common endocrine disorder which causes microvascular and macrovascular complications. Herbal medicines derived from plant extracts are used to treat various diseases because of its fewer side effects. The present investigation includes a screening of phytochemicals and evaluation of the in-vitro and in-vivo anti-diabetic activity of Hellenia speciosa leaves ext...

R. Ramya * and R. Dhamotharan

Department of Biochemistry, J.B.A.S College for Women, Teynampet, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5016-24

5016-5024

102

51

27.

SYNTHESIS, CHARACTERIZATION, CYTOTOXIC AND ANTIOXIDANT STUDIES OF MIXED LIGAND SCHIFF BASE COMPLEXES DERIVED FROM P- NITROANILINE AND 2, 4-DINITROANILINE

Four isatin mixed ligand complexes of the type ML1L2, where M =Co(II), Ni(II), Cu(II) and Zn(II) (LI = Schiff base formed by the condensation of isatin and p-nitroaniline and  L2= Schiff base formed by the condensation of isatin and 2,4-dinitroaniline) are synthesized. Mixed ligand complexes are different from routine metal complexes that they have a minimum of two special kinds of ligands linked...

M. Mohan, V. Veena, S. Kezo and K. R. Reddy *

PG Department & Research Studies in Chemistry, Government Science College (Autonomous), Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5025-31

5025-5031

207

53

28.

ENCAPSULATION OPTIMIZATION OF TAMARIND SEED ANTIOXIDANTS IN ALGINATE HYDROGELS USING RESPONSE SURFACE METHODOLOGY: STUDY OF CONTROLLED RELEASE BEHAVIOR IN SIMULATED GASTROINTESTINAL CONDITIONS

Tamarindus indica seeds - a byproduct of the food industry, are generated in huge amounts during tamarind pulp processing. These seeds are a source of a wide range of polyphenols with natural antioxidant content. In this study, we have encapsulated the polyphenolic components extracted from the seeds in an optimized condition. Statistical optimization of the encapsulation parameters was done using...

A. Sarkar and U. Ghosh *

Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5032-40

5032-5040

113

47

29.

INHIBITORY EFFECT OF ETHANOL EXTRACT OF MELASTOMA MALABATHRICUM LEAVES ON INFLAMMATORY SPLA2 ENZYME AND ITS ABILITY TO REDUCE THE CELL VIABILITY OF PC3 CELL LINE

Melastoma malabathricum is a medicinal plant found throughout Southeast Asian countries. Traditionally M. malabathricum was used for treating diseases such as hemorrhoids, cuts and wounds, toothache, and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts of M. malabathricum such as anti-nociceptive, anti-inflammatory, wound healing, anti-diarrheal...

P. Sophiya, N. S. Lohith, A. S. Giresha, M. Narayanappa, R. S. Meti, A. D. Sathisha and K. K. Dharmappa *

Department of Studies and Research in Biochemistry, Jnana Kaveri Post Graduate Centre, Mangalore University, Mangaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5041-50

5041-5050

111

50

30.

ASSESSING THE EFFECT OF FARTLEK TRAINING ON PERCEIVED WELLNESS OF UNIVERSITY STUDENTS OF SAUDI ARABIA: A RANDOMIZED CONTROLLED TRIAL

Wellness is described as positive health of an individual as indicated by the quality of life and a sense of well-being. This research aimed to assess the effect of supervised fartlek training on Perceived Wellness of University Students of Saudi Arabia. A sample of forty students enrolled in various courses of KFUPM was selected for the study; the mean age was 18.52 ± 0.599 years. Two groups wer...

V. C. Antony * and R. Tomar

Department of Physical Education, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.10(11).5051-56

5051-5056

123

54

31.

DEVELOPMENT AND VALIDATION OF GAS CHROMATOGRAPHY METHOD FOR THE DETECTION OF RESIDUAL ETHANOL, ISOPROPYL ALCOHOL AND TOLUENE IN AMIODARONE HYDROCHLORIDE DRUG SUBSTANCE

A simple and reliable head space Gas Chromatographic method has been developed for the determination of residual ethanol, isopropyl alcohol and toluene in Amiodarone hydrochloride drug substance. The proposed method is based on flame ionization detection technique with DB 624 as stationary phase. Linearity of detector response was established up to 150 % of the limit level for ethanol, isopropyl a...

A. J. D’Souza *, R. S. Lokhande and T. Anvekar

Department of Chemistry, St. Xaviers College, Mapusa, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5057-62

5057-5062

103

49

32.

ASSESSMENT OF GREEN TEA EXTRACT ON TESTICULAR ACTIVITY IN STREPTOZOTOCIN-INDUCED DIABETIC SPRAGUE-DAWLEY RAT MODEL

Diabetes mellitus is a lasting metabolic disability regarding enhance etiology and permanent degenerating complications. Sexual abnormalities (Hypogonadism, infertility, etc.) are outfit a two of the discombobulate ingenious stringency of diabetes mellitus. Different hypoglycemic agents are used to control diabetes mellitus, but very few formulations are available to treat secondary complications....

K. Singh, S. Devi and P. P. Pankaj *

Department of Zoology, Nagaland University, Lumami, Nagaland, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5063-68

5063-5068

97

58

33.

EVALUATION OF IMPACT OF MEDICATION RECONCILIATION IN STROKE PATIENTS IN A TERTIARY CARE HOSPITAL

Stroke is a medical condition in which poor blood flow to the brain results in cell death and is the second most common cause of death after coronary artery disease. Stroke patients with added co-morbidities on an average are prescribed with 6-10 medications which increase the potential for Drug-Related Problems (DRPs) including inappropriate dose or indication for medication and Adverse Drug Even...

S. Krishna *, M. T. Gedhanjali, J. N. Jacob and M. Fouzan

Department of Pharmacy Practice, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5069-74

5069-5074

113

50

34.

CYTOTOXIC AND APOPTOGENIC EFFECTS OF A BIOACTIVE FRACTION ISOLATED FROM THE LEAVES OF A TRADITIONAL MEDICINAL PLANT TRIDAX PROCUMBENS

Objective: To investigate the anti-proliferative effects of T. procumbens leaf extracts on the growth of MCF 7, Hep G2 and K562 cells. An attempt was made to partially purify the cytotoxic acetone extract using a bioassay-guided isolation procedure and the apoptosis-inducing activity of bioactive sub-fraction, F15 (fraction 15), was probed further against K562 cells. Methods: Cytotoxicity of extra...

T. Lakshmipriya, T. Soumya, P. R. Jayasree and P. R. M. Kumar *

Department of Biotechnology, University of Calicut, Thenhipalam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5075-86

5075-5086

103

47

35.

DEVELOPMENT AND STANDARDIZATION OF WOOD APPLE (LIMONIA ACIDISSIMA) INCORPORATED NOVEL FOOD PRODUCTS

Aim: This study was planned to keep in view on the medicinal and nutritional importance of wood apple pulp, and to utilize them by value-added product as fresh pulp incorporated spread and its dry powder incorporated cookies. Objectives of the study: To develop food products by using wood apple pulp and its dry powder and to analysis the nutritional value antioxidant content and phytochemical prop...

C. Hemalatha and S. Parameshwari *

Department of Nutrition & Dietetics, Periyar University, Salem, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5087-93

5087-5093

110

46

36.

ANALYSIS OF TARAXEROL AND TARAXASTEROL IN HAIRY ROOT CULTURES OF TARAXACUM OFFICINALE WEBER

Taraxacum officinale (TO) Weber commonly known as dandelion has contained triterepenes-taraxasterol and taraxerol in its roots which are nowadays being recognized as potent anticancer compounds. The main objective behind the present study was to increase the yield of taraxasterol and taraxerol through induction of hairy roots in Taraxacum officinale Weber using two strains of Agrobacterium rhizoge...

K. Sharma

SGT College of Pharmacy, Gurugram, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(3).5094-02

5094-5102

107

49

37.

IN-VITRO AND IN-VIVO QUANTITATIVE ESTIMATION OF TOTAL PHENOLS, ASCORBIC ACID CONTENT AND ANTIOXIDANT ACTIVITY IN NORMAL FLOWER AND FLOWER GALL OF CRATAEVA RELIGIOSA

Plant galls are remarkable close associations between plants and insects, in which the plant produces an abnormal growth of tissue in response to a specific stimulus from the attacking insect. The present investigation was undertaken to assess the antioxidant activity as well as the total phenols and ascorbic acid content in in-vivo (normal flower and galled flower) and in-vitro (unorganized stati...

S. Sharma

Plant Pathology, Tissue Culture and Biochemistry Laboratory, Department of Botany, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5103-08

5103-5108

112

55

38.

EFFECT OF PHARMACIST DIRECTED COUNSELLING SERVICES ON KNOWLEDGE, ATTITUDE, AND PRACTICE (KAP) AND BLOOD PRESSURE CONTROL IN HYPERTENSIVE PATIENTS: A RANDOMIZED CONTROL TRIAL

Pharmacists play a vital role in providing counseling to the hypertensive patients to understand disease, risk factors, medications, and non-pharmacological measures required in controlling Blood Pressure (BP). This study aims to evaluate the impact of pharmacist delivered counseling services on KAP levels and control of BP in hypertensive patients. A prospective, open-labeled, randomized control ...

N. Goruntla *, V. Mallela and D. Nayakanti

Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5109-16

5109-5116

130

58

39.

COMPARISON OF PHYSICOCHEMICAL, THERMAL, PASTING AND MORPHOLOGICAL PROPERTIES OF WEED RICE AND RICE STARCHES

A novel starch was isolated from weed rice crop and its starch properties were compared with rice starch. The starch properties studied were physicochemical, pasting, thermal and X-ray diffraction. The amylose content and swelling power (g/g) of weed rice starch was 13.7% and 19.8 g/g, respectively. Light transmittance (%) of starch paste from weed rice was observed higher as compared to rice star...

V. Sharma * and K. S. Sandhu

Department of Food Science and Technology, Chaudhary Devi Lal University, Sirsa, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5117-23

5117-5123

111

48

40.

IN-VIVO ROENTGENOGRAPHIC EVALUATION OF COLON TARGETED 5-FLUOROURACIL PELLETS

Objective: This study was an attempt to explore the latent of colon specificity approach utilizing pH-sensitive and time-dependent characteristics of polymers for defined colonic release of 5-Fluorouracil (5-FU). Method: The pellets were prepared by extrusion-spheronization method which is an industry-accepted method due to its ease of formulation. The prepared pellets were the matrix of 5-Fluorou...

J. K. Bahekar * and S. J. Wadher

School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5124-36

5124-5136

127

47

41.

SYNTHESIS, CHARACTERIZATION AND BINDING PROPERTIES TOWARDS CT-DNA OF MIXED-LIGAND Cu(II) COMPLEX WITH 2-AMINOBENZONITRLE AND OCTANOATE ION

A novel coordination complex of 2-aminobenzonitrile (ABN) and octanoate ion (OC) with Cu(II) metal ion has been prepared by using microwave irradiation. The molecular formula and the geometry of the complex have been deduced from elemental analysis, molar conductance, magnetic moment, electronic spectra, FT- IR spectra, cyclic voltammetry, thermal analysis and EPR spectra. The molar conductance va...

R. Govindharaju *, S. Balasubramaniyan, L. Palanivelan, M. M. Risana and V. M. Meenakshi

PG & Research Department of Chemistry, Thanthai Hans Roever College (Autonomous), Perambalur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5137-45

5137-5145

223

54

42.

ANTIEPILEPTIC DRUGS: PRESCRIPTION PATTERN, HEMATOBIOCHEMICAL CHANGES AND ADVERSE EFFECTS: A RETROSPECTIVE STUDY IN EASTERN PROVINCE OF SAUDI-ARABIA

Objectives: To retrospectively determine the prescription pattern of antiepileptic drugs (AEDs), hematobiochemical changes, and associated adverse effects. Methodology: A retrospective observational study was conducted at the Department of Neurology, King Fahad Hospital of the University, Khobar, KSA. Data Collection was through Electronic Health Record. A designed validated form to record demogra...

F. H. Pottoo *, F. Al-Khalifa, F. Al-Hassar, S. Al-Muhanna, M. Al-Ghamdi, D. Aljaafari and R. Joseph

Department of Pharmacology,College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.10(11).5146-53

5146-5153

163

55

43.

ALPHA-AMYLASE INHIBITION AND MEMBRANE STABILIZING EFFECT OF THE STEM BARK OF MAESOBOTRYA DUSENII HUTCHINSON

Introduction: Control of blood glucose level is a critical approach in the management of diabetes mellitus and its complications. This study investigated the α-amylase inhibition and erythrocyte membrane stabilization effect of extracts of Maesobotrya dusenii Hutch. Method: Powdered stem bark of M. dusenii (100g) was extracted with methanol. The plant material (400g) was also successively macerat...

S. Mikailu *, M. C. Okorafor and K. A. Abo

Department of Pharmacognosy and Phytotherapy, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.10(11).5154-59

5154-5159

107

570

44.

EFFECT OF PIPER NIGRUM (LINN.) ON INFERTILITY INDUCED BY ETHIONAMIDE AND PARA AMINO SALICYLIC ACID IN MALE SPRAGUE-DAWLEY RATS

Tuberculosis is a global problem. The tuberculosis is the common cause of male infertility in developing countries due to the use of second-line anti-tuberculosis drugs (ATB). The experiments were conducted at Unique Bio diagnostic Enterprise Veterinary Pathology Laboratory Parel, Mumbai for chemiluminescence immunoassay to study the levels of testosterone in male Sprague-Dawley rats. The histolog...

G. V. Zodape * and V. S. Gaikwad

Department of Zoology, S.S. & L.S. Patkar College of Arts and Science & V.P. Varde College of Commerce and Economics, Goregaon (West), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5160-66

5160-5166

97

48

45.

SYNTHESIS AND CYTOTOXICITY STUDY OF PLANT DERIVED NANOCOMPOSITE

The present study is a small attempt of synthesis of gold nanocomposites with anticancer drug cisplatin and their cytotoxicity test on HeLa cell line. There are many well-established reports on the synthesis of gold nanoparticles (AuNPs) chemically. But as an ecofriendly alternative various plant extracts also been used for the reduction and synthesis of AuNPs. AuNPs in this study have been synthe...

B. Baishya *, M. C. Kalita and N. N. Barman

Department of Biotechnology, Pandu College, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5167-78

5167-5178

200

43

46.

GC- MS ANALYSIS AND IN-SILICO DOCKING ANALYSIS OF METHANOLIC EXTRACT OF FICUS RACEMOSA BARK

Indian medicinal plants are considered as a vast source of several pharmacologically active principles and compounds, which are commonly used in home remedies against multiple ailments. Plant secondary metabolites such as alkaloids, tannins, steroids, terpenoids, coumarins and phenolic compounds and their semi-synthetic derivatives continue to play an important role in anticancer drug therapy. Mol...

A. Poongothai * and S. Annapoorani

Department of Biochemistry, Sacred Heart College (Autonomous), Tirupattur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5179-93

5179-5193

94

45

47.

Co(II), Ni(II), Cu(II) COMPLEXES OF SULPHUR CONTAINING SCHIFF BASE LIGAND-SYNTHESIS, SPECTROSCOPIC, MOLECULAR MODELLING AND ANTIMICROBIAL STUDIES

Metal (II) complexes of Co, Ni and Cu with Schiff base derived from 2, 4-Dihydroxy-5-acetylacetophenone and Aminothiophenol (DAAAP) were synthesized and characterized by elemental analysis, FTIR, IH NMR, electronic spectra, thermal analysis, magnetic susceptibility and conductometric measurements. On the basis of these studies, a six coordinated octahedral geometry has been proposed for all the co...

P. S. Reddy

Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).5194-02

5194-5202

90

38

48.

TRIGONELLA FOENUM-GRAECUM L. SEED MUCILAGE-BASE MUCOADHESIVE MICROSPHERES OF DICLOFENAC SODIUM

The study was aimed to discover the properties of Trigonella foenum-graecum L. seed mucilage (TFGSM) in the formulation of mucoadhesive microspheres of diclofenac sodium to prolong the residence time at the site of absorption. Diclofenac sodium microspheres were formulated by ion gelation technique. Different polymer ratios of TFGSM and sodium alginate were used to formulate eight formulations (F1...

S. Adimoolam * and S. Phonhaxa

Department of Dosage Form Design, Faculty of Pharmacy, MAHSA University, Selangor, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.10(11).5203-10

5203-5210

349

34