Volume 17 (2026) - Issue 8, August
Review Articles
BIOACTIVE POTENTIAL OF HERBS IN LIVER AND HEART HEALTH: INSIGHTS INTO ANTIOXIDANT, ANTI-INFLAMMATORY AND VASCULAR PATHWAYS
Cardiovascular and liver diseases are major contributors to global mortality and morbidity, sharing common underlying mechanisms such as oxidative stress, chronic inflammation, and endothelial dysfunction. The functional interplay between the heart and liver further underscores the importance of therapeutic strategies targeting these interconnected pathways. While conventional pharmacological inte...
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PHARMACOLOGICAL POTENTIAL AND BIOACTIVE PROFILE OF MEDICINAL LICHEN PARMOTREMA PERLATUM: A REVIEW
Parmotrema perlatum or Parmelia perlataor Kalpasi or black stone flower is a foliose lichen traditionally valued for its medicinal and aromatic properties. In recent years, the species has attracted growing scientific interest because of its rich content of unique secondary metabolites and wide range of biological activities. These review highlights the botanical features, phytochemical profile, a...
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AN INTEGRATIVE REVIEW OF FERMENTED MILLET AMBALI POWDER: SYNERGIES BETWEEN AYURVEDIC PHARMACOLOGY AND CONTEMPORARY NUTRITIONAL SCIENCE
Ambali is a traditional lactic acid-fermented porridge prepared from finger millet (Eleusine coracana), representing a significant convergence point between functional food science and culinary traditions. This narrative review examines the preparation, proposed health benefits, and mechanistic basis of dehydrated Ambali powder by integrating Ayurvedic Dravyaguna (pharmacological) principles with ...
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EXPLORING THE EFFECTIVENESS AND SAFETY OF COMPLEMENTARY AND HERBAL MEDICINES IN PEDIATRIC COUGH MANAGEMENT: A SYSTEMATIC REVIEW
Background: Cough is a prevalent problem that pediatricians and respiratory physicians frequently encounter. Various cultures have been using herbal remedies for a long time. However, there is a general lack of randomized controlled trial data to support their effectiveness. In order to provide a comprehensive overview of the existing literature, this systematic review aims to evaluate the efficac...
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MILK PROTEIN-BASED HYDROGELS: AN OVERVIEW OF THEIR EXTRACTION, SYNTHESIS AND BIOMEDICAL APPLICATIONS
Hydrogels are sophisticated category of biomaterials that closely resembles the properties of living tissues. Various polymers have been studied for creating hydrogels that closely mimic the structure and function of the extracellular matrix. Proteins that can be easily modified, have specific biochemical effects, and respond to external stimuli are considered promising for making hydrogels used i...
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A REVIEW ON EXOSOME-MEDIATED INTER-ORGAN COMMUNICATION IN METABOLIC DISEASES: A CONCEPTUAL FRAMEWORK-LINKING KEY METABOLIC TISSUES FOR THERAPEUTIC APPLICATIONS
Recent years have seen increasing recognition of metabolic diseases like type 2 diabetes mellitus (T2DM), obesity, and non-alcoholic fatty liver disease (NAFLD) as systemic disorders characterized by aberrant inter-organ communications. As vesicles that include miRNAs, proteins, lipids, and metabolites, exosomes have been demonstrated as an important mechanism underlying the inter-organ communicat...
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A REVIEW ON MAJOR HISTOCOMPATIBILITY: IMPLICATIONS IN TRANSPLANTATION AND GRAFT REJECTION
The Major Histocompatibility Complex (MHC), which can also be known as the Human Leukocyte Antigen (HLA) system in humans, is one of the significant elements in transplantation immunobiology due to their role in antigen presentation and immunity tolerance. Polymorphism in particular is one of the main characteristics of MHC that determines its role in donor-recipient matching, affecting the outcom...
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UNLOCKING NATURE’S POWER: A DECADE OF MEDICINAL PLANTS REVOLUTIONIZING CANCER THERAPY
Cancer is a severe global health burden, responsible for significant morbidity and mortality globally. Despite breakthroughs in traditional therapies including chemotherapy, radiation, and surgery, these methods are frequently associated with side effects, drug resistance, and limited selectivity. In recent years, medicinal plants have received increased interest as a source of bioactive chemicals...
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NITROSAMINE IMPURITIES IN PHARMACEUTICALS: ANALYTICAL METHODS, REGULATORY FRAMEWORK, AND RISK CONTROL– A REVIEW
Nitrosamine impurities have emerged as a major global concern in pharmaceutical quality due to their well-established mutagenic and carcinogenic potential. Since the detection of N-nitrosodimethylamine (NDMA) in angiotensin receptor blockers in 2018, regulatory agencies worldwide have implemented risk-based control frameworks for nitrosamine impurities in drug substances and finished products. Nit...
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ROLE OF WILD VEGETABLES IN NUTRITIONAL ENRICHMENT: A COMPREHENSIVE REVIEW WITH SPECIAL REFERENCE TO KARJAT TEHSIL
The indigenous flora thrives naturally without the need for cultivation or maintenance. This flora is favored by the local population as a viable alternative for essential dietary sustenance, offering nutritional balance and medicinal benefits. An extensive survey of wild edible vegetables from the Karjat Tehsil in the Ahilyanagar District was conducted in year 2023-24 to assess the significance o...
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Research Articles
ISOLATION OF URSOLIC ACID FROM LEAVES OF EUCALYPTUS TERETICORNIS SMITH: ANTIOXIDANT, ANTIDIABETIC, MOLECULAR DOCKING, AND ADMET PROFILING
Ursolic acid is a pentacyclic triterpenoid widely distributed in medicinal plants and is recognized for a broad spectrum of biological activities, including antioxidant and antidiabetic effects. In the present study, leaves of Eucalyptus tereticornis Sm. were subjected to sequential solvent extraction, and ursolic acid was isolated by column chromatographic purification. Structure of the isolated ...
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PHYTOCHEMICAL SCREENING, ANTIBACTERIAL AND ANTI-INFLAMMATORY ACTIVITIES, AND ACUTE ORAL TOXICITY OF ALBIZIA ANTUNESIANA HARMS: A ZIMBABWEAN MEDICINAL PLANT TRADITIONALLY USED AGAINST INFECTIONS AND INFLAMMATION
For many generations in Zimbabwe, Albizia antunesiana tree has been used in traditional healing. It has been widely used to treat infections, inflammation and other chronic illnesses such as diabetes. This study sought to provide scientific evidence to this ancient wisdom by testing the bark and leaves against modern biological markers. Phytochemical analysis revealed the presence of bioactive com...
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EFFECT OF HESPERIDIN ON THE PHARMACOKINETIC AND PHARMACODYNAMIC PROFILES OF GLIBENCLAMIDE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from impaired insulin secretion, insulin action, or both, leading to serious long-term complications. Glibenclamide, a widely used sulfonylurea antidiabetic drug, is effective in stimulating insulin secretion; however, its therapeutic performance can be influenced by pharmacokinetic variability an...
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STRUCTURE BASED COMPUTATIONAL IDENTIFICATION OF POTENTIAL THERAPEUTIC LEADS TARGETING MSH3 PROTEIN
Huntington's disease is a progressive neurological condition characterized by motor dysfunction, cognitive decline, and psychiatric disturbances. Recent studies indicate that abnormalities in DNA mismatch repair mechanisms, particularly involving the MSH3 protein, contribute to the expansion of CAG repeats and the progression of the disease. In the current investigation, an integrated in-silico st...
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STANDARDIZATION OF SIDDHA POLY HERBAL FORMULATION VILVATHY LEGIUM
The standardization of Siddha formulations is a critical step for establishing consistent chemical profiles and ensuring quality control in the commercial manufacturing of herbal drugs. Vilvathy Legium is a Siddha polyherbal formulation in the Siddha Sastric textbook, Athmarakshamirtham Ennum Vaidhiya Sarasangiragam, authored by Kandhasamy Mudhaliyar and indicated for conditions such as gastrointe...
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GREEN SYNTHESIS OF SILVER NANOPARTICLES USING PTERIS VITTATA L. EXTRACT AND STUDIES ON ITS ANTIBACTERIAL ACTIVITY AGAINST ESCHERICHIA COLI
The aim of the present investigation is to synthesize and characterize silver nanoparticles (AgNP) for their antibacterial activities. Aqueous frond extract of Pteris vittata L. was used for synthesis of silver nanoparticles. The phytosynthesized silver nanoparticles were characterized using UV-Vis spectrophotometer, SEM, TEM, FE-SEM, EDS, FT-IR. Morphologically, they are spherical in shape where ...
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NETWORK PHARMACOLOGY-BASED IN-SILICO INVESTIGATION OF MAARADAIPPU CHOORANAM: A HYPOTHESIS-GENERATING STUDY ON ITS POTENTIAL MULTI-TARGET EFFECTS IN ATHEROSCLEROSIS
Background: Cardiovascular diseases (CVDs), primarily driven by atherosclerosis, remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is a chronic inflammatory disorder characterized by lipid accumulation, endothelial dysfunction, oxidative stress and plaque formation, ultimately leading to Acute Myocardial Infarction. Maaradaippu chooranam, a classical siddha polyherbal ...
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SPECTRUM OF HISTOPATHOLOGICAL FINDINGS IN CHOLECYSTECTOMY SPECIMENS WITH SPECIAL REFERENCE TO CARCINOMA OF GALLBLADDER – A 5-YEAR RETROSPECTIVE STUDY
Background: Cholecystectomy is one of the most frequently performed abdominal surgeries worldwide for symptomatic gallstones and inflammatory gallbladder lesions. Routine histopathological examination remains the gold standard for detection of inflammatory, premalignant and malignant lesions, while immunohistochemistry is reserved for selected diagnostically challenging malignant cases. Objective:...
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DRUG-RELATED PROBLEMS AND CLINICAL PHARMACIST INTERVENTIONS IN HOSPITALIZED NEUROLOGICAL PATIENTS: A PROSPECTIVE OBSERVATIONAL STUDY
Background: Drug-related problems (DRPs) are common among hospitalized neurological patients due to complex pharmacotherapy and polypharmacy. Clinical pharmacists play a vital role in identifying and managing these problems. Objectives: This study evaluated the prevalence and types of DRPs among hospitalized neurological patients and described clinical pharmacist interventions and their outcomes. ...
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FACTORS INFLUENCING USAGE OF INSULIN IN TYPE 2 DIABETES MELLITUS PATIENTS OF TERTIARY CARE TEACHING HOSPITAL OF GUJARAT
Introduction: Type 2 diabetes mellitus (T2DM) is a rapidly increasing public health problem in India, with many patients eventually requiring insulin therapy due to progressive β-cell dysfunction. Despite strong evidence supporting insulin’s role in achieving glycaemic control and preventing complications, initiation of insulin is frequently delayed because of psychological insulin resistance (...
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MICROBIOLOGICAL SPECTRUM AND DIAGNOSTIC APPROACH IN NEONATAL SEPSIS
Background: Neonatal sepsis is a life-threatening systemic infection caused by bacteria, fungi, or viruses, characterized by hemodynamic instability and variable clinical presentations. Early and accurate diagnosis remains challenging and typically relies on a combination of clinical assessment, laboratory parameters, and microbiological confirmation, most commonly through blood culture. Materials...
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A PROSPECTIVE STUDY TO OBSERVE DRUG UTILIZATION PATTERN USING WHO DRUG PRESCRIBING INDICATORS IN PATIENTS OF ISCHEMIC HEART DISEASE AT TERTIARY CARE TEACHING HOSPITAL
The prescription writing process by prescriber is a very important step, and prescription error can lead to irrational use of medicine. The objective of the research is to describe and evaluate drug utilization patterns using WHO core indicators at the tertiary level. This is prospective observational study which was carried out in indoor IHD patients (IPD). WHO drug prescribing indicators were us...
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THE RELATIONSHIP BETWEEN SOCIAL MEDIA ADDICTION AND ACADEMIC PERFORMANCE AMONG MEDICAL UNDERGRADUATE STUDENTS
Background: Social media usage has become widespread among medical undergraduates. Although it provides opportunities for communication and academic collaboration, excessive use may adversely affect academic performance. Objective: To determine the association between duration of social media usage and academic performance among medical undergraduate students and to assess the correlation between ...
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MICROCOCCUS ANTARCTICUS HC-2: OPTIMIZATION AND EVALUATION OF ANTIMICROBIAL METABOLITES
Optimization of culture conditions to enhance bioactive metabolite production by Micrococcus antarcticus HC-2 was undertaken in this study. The culture broth, grown in Yeast Extract–Malt Extract–Dextrose (ISP-2) medium and extracted with Ethyl acetate exhibited high antimicrobial activity against test microorganisms, including Gram-negative, Gram-positive bacteria and fungi. For efficient prod...
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DEVELOPMENT AND VALIDATION OF A SIMPLE AND NOVEL UV SPECTROPHOTOMETRIC APPROACH FOR THE QUANTITATIVE ESTIMATION OF ELLAGIC ACID IN BULK AS PER ICH GUIDELINES
Ellagic acid, a naturally occurring polyphenolic compound is found in various fruits and vegetables and has attracted considerable attention due to its broad spectrum of biological and pharmacological properties. Several key aspects of ellagic acid, including its antioxidant activity, anti-cancer properties, anti-inflammatory effects, protective role in cardiovascular health, as well as its antiba...
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COMPARATIVE BIOCHEMICAL SAFETY OF ITRACONAZOLE AND TERBINAFINE IN SUPERFICIAL DERMATOPHYTOSIS: APROSPECTIVE STUDY
Objectives: Systemic antifungal therapy is widely used for dermatophytosis, but concerns regarding biochemical safety and adverse effects remain clinically relevant. This study aimed to compare the biochemical safety profile of oral itraconazole and terbinafine in patients with superficial dermatophytosis. Methods: In this prospective comparative clinical study, 180 adult patients with potassium h...
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COMPARATIVE QUALITY ASSESSMENT OF MARKETED SILYMARIN TABLETS
In recent years, the popularity of silymarin, lauded for their nutritional and health benefits, has soared. Among these products, silymarin and its main constituent, silibinin, have a hepatoprotective effect due to their antioxidant activity as well as a membrane-stabilizing property that inhibits or stops the process of lipid peroxidation. Additionally, they may help avoid gallbladder and spleen ...
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PHYTO-CHEMISTRY WORTH CRACKING: QUALITATIVE AND QUANTITATIVE PHYTOCHEMICAL ANALYSIS OF ETHANOLIC PUNICA GRANATUM L. SEED EXTRACT
Pomegranate (Punica granatum L.) seeds represent a biologically rich and underutilized by-product of fruit processing whose therapeutic potential has gained considerable scientific interest in recent years. This study presents a systematic phytochemical investigation of the ethanolic seed extract of Punica granatum, encompassing both qualitative screening and rigorous quantitative estimation of th...
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PREVALENCE OF VITAMIN D DEFICIENCY AND ITS ASSOCIATION WITH INSULIN RESISTANCE AMONG INDIAN WOMEN WITH POLYCYSTIC OVARY SYNDROME: EVIDENCE FROM A CROSS-SECTIONAL STUDY
The current study aims to assess whether circulating levels of 25(OH) D are related to insulin resistance in PCOS individuals, or whether this association is confounded by other pathophysiological factors related to the syndrome. This cross-sectional study included 151 women who were diagnosed with PCOS based on the Rotterdam consensus, recruited from a tertiary healthcare center in South Gujarat,...
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COMPARISON OF CLINICAL OUTCOMES OF SITAGLIPTIN AND GLICLAZIDE IN THE MANAGEMENT OF UNCOMPLICATED TYPE 2 DIABETES MELLITUS
This study evaluated and compared the efficacy and safety of sitagliptin and gliclazide in patients with uncomplicated type 2 diabetes mellitus. A total of 291 patients were assigned to two treatment groups receiving either sitagliptin or gliclazide. Glycemic parameters, including fasting blood glucose, postprandial blood glucose, and glycated hemoglobin levels, were assessed over a period of six ...
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ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE REGARDING PREGNANCY-INDUCED HYPERTENSION AMONG HYPERTENSIVE ANTENATAL MOTHERS IN KALLAKURICHI DISTRICT, TAMIL NADU: A CROSS-SECTIONAL STUDY
Background: Pregnancy-induced hypertension (PIH) is one of the leading causes for maternal mortality and morbidity among pregnant mothers in India. PIH is characterized by elevated blood pressure at or above 140/90 mmhg during pregnancy. Adequate knowledge, positive attitude and practises are at most important among the hypertensive mothers for proper management and prevention of maternal and neon...
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PROSTHETIC CHALLENGES AND REHABILITATION STRATEGIES IN AN ELECTRICAL BURN SURVIVOR WITH MULTIPLE LIMB AMPUTATIONS: A CASE STUDY
Background: Electrical injuries are a common cause of traumatic amputations in developing countries, especially among adolescents. High voltage electrical accidents often result in loss of both upper and lower limbs on the same side, leading to major physical and psychological difficulties during rehabilitation. Objective: To describe the prosthetic challenges, multidisciplinary management, and fu...
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FORMULATION AND EVALUATION OF RESVERATROL LOADED NANOGEL FOR ONYCHOMYCOSIS
Nail plate disorders account for 10% of all dermatological disorders having an impact on 20-25% of population worldwide. Nail bed infections are difficult to treat due to shorter nail residence time of topically applied formulation and unavailability of novel formulations in the market for antimicrobial drug. Increased occurrence of onychomycosis in recent times and because of involvement of occup...
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