Volume 1 (2010) - Issue 9, September (Suppl.)
Review Articles
NIOSOMES IN TARGETED DRUG DELIVERY: SOME RECENT ADVANCES
Niosomes are self assembled vesicles composed primarily of synthetic surfactants and cholesterol. They are analogous in structure to the more widely studied liposomes formed from biologically derived phospholipids. Niosomes represent an emerging class of novel vesicular systems. Niosome formation requires the presence of a particular class of amphiphile and aqueous solvent. In recent years a compr...
4906
1475
PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITIES OF PSIDIUM GUAJAVA: A REVIEW
Guava (Psidium guajava Linn.) Family Myrtaceae is important plant used traditionally for medicinal purposes. Guava is rich in antioxidants compounds and contains a high level of ascorbic acid. The pharmacological actions and the medicinal uses of aqueous extracts of guava leaves in folk medicine include the treatment of various type of gastrointestinal disturbances such as vomiting, diarrhea, inhi...
8813
4500
Research Articles
IN VITRO ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF STEM OF MUSSAENDA ERYTHROPHYLLA
Mussaenda erythrophylla is native to western tropical Africa, occasionally seen in gardens and parks as ornamental plant in India and belongs to Rubiaceae family. The present study was concentrated on the in vitro antioxidant methods like superoxide radical, hydroxyl radical, lipid peroxidation and DPPH radical methods. The ethylacetate and methanolic extracts of Mussaenda erythrophylla were subje...
3315
1462
SYNTHESIS AND CHARACTERISATION OF IBUPROFEN, KETOPROFEN PRODRUG FOR TASTE MASKING USING β- CYCLODEXTRIN
The Profens have indicated the gastrointestinal side effects due to the acidic moiety of the profen. The Profens are bitter in taste and it is omitted by mostly children. Therefore an attempt has been made to prepare the ester Prodrug using ethyl alcohol and butyl alcohol and its bitter taste is masked by using β-Cyclodextrin. The prepared prodrugs are characterised by melting point, UV and IR sp...
7448
1756
FAST DISSOLVING CELECOXIB TABLETS CONTAINING SOLID DISPERSION OF CELECOXIB
Celecoxib is a selective cox-2 inhibitor is indicated to the treatment of Osteoarthritis, Rheumatoid arthritis, acute painful primary Dysmenorrhoea. It is also superior to other NSAID’s, due to lower incidences of symptomatic gastrointestinal ulcer complications than other NSAID’s. Celecoxib is practically insoluble in water. The present investigation deals with enhancement of dissolution rate...
3940
1721
PHARMACOGNOSTICAL STUDIES OF LEAVES OF SPINACIA OLERACEA LINN.
The paper presents the pharmacognostical studies of leaves of Spinacia oleracea Linn. (Amaranthaceae) commonly known as Palak, a traditional medicinal plant with high nutritional value, used as anti diabetic, anti bacterial and hepatoprotective agent. Extensive literature survey revealed that no reports were available on organoleptic, microscopic and physicochemical properties of Spinacia oleracea...
4264
1303
TO EVALUATE THE EFFECTIVENESS OF SOLID DISPERSION IN FORMULATION OF FAST DISINTEGRATING TABLETS
Flurbiprofen is a water insoluble non-steroidal anti inflammatory drug and belongs to BCS Class II categories. Solid dispersion is a technique by which we can improve it water solubility. By the help of fast dissolving formulation we can evaluate the effectiveness of solid dispersion. In this research work the solid dispersion of flurbiprofen with polymer like PVP K25, PVP K30, PVP K29-32, and PEG...
2543
960
EVALUATION OF ANALGESIC ACTIVITY OF MOMORDICA DIOICA ROXB. WILLD FRUIT PULP
In the present study Momordica dioica Roxb willd (Cucurbitaceae) fruit pulp was successively extracted with petroleum ether, ethyl acetate and methanol. All extracts were vacuum dried to yield the respective extracts. All extracts were evaluated by non-narcotic models like acetic acid induced writhing syndrome test and narcotic models like hot plate for its analgesic activity in doses of 50 mg/kg ...
3025
1027
PROTECTIVE EFFECT OF TOCOPHEROL AGAINST MERCURIC CHLORIDE TOXICITY ON BLOOD PARAMETERS
Mercury is a naturally occurring element that may exist in elemental, inorganic or organic form and in various oxidation states. Mercury is widely used in thermometers, thermostats, mercury arc lamps, mercury vapor lamp, mirror, extracting gold and silver from ores, electric rectifiers, dental amalgams for filling teeth, ointments, disinfectants, antiseptics, etc. while inorganic mercury salt i.e....
2802
1073
COMPARATIVE STUDIES ON SKIN PERMEATION OF MICONAZOLE USING DIFFERENT NOVEL CARRIERS
Purpose: Miconazole nitrate is a widely used antifungal agent but its use in topical formulation is not efficacious because deep ereated fungal infections are difficult to treat with conventional topical formulation. The purpose of this study was to prepare miconazole incorporated different novel carriers such as liposomes, ethosomes and to compare their in vitro skin permeation studies with plane...
3422
1416
A STUDY ON THE EFFECT OF ISOBARIC HYPOXIA ON ANTIOXIDANT ENZYME ACTIVITY AND LIPID PEROXIDATION IN RAT BRAIN
In the present work, an attempt was made to study the effect of isobaric hypoxic hypoxia (10%) on rat brain. Since literatures support generation of free radicals during post ischemic/hypoxic period, here hypoxia followed by reoxygenation is dealt with as the single problem. Subsequently, as brain shows regional variations in its function and metabolic activities an attempt was made to study effec...
2586
966
PHARMACOGNOSTIC STUDIES OF NERIUM INDICUM
The study is aimed at development of physicochemical parameters and to investigate the active principle present in Nerium indicum. Nerium indicum (Apocynacea) commonly known as kanner is an important plant used against various disorders in indigenous system of medicine such as cardiotonic, antibacterial and antidiabetic. Thus from the extensive literature survey it was revealed that no reports wer...
3895
1351
EFFECT OF ASCORBIC ACID AGAINST LEAD (Pb) TOXICITY
Present study deals with effect of Vit. C against lead toxicity animals were divided into three groups of six rats each. One group of served as control which received only vehicle, second group was given lead acetate at a dose level of 0.3mg/ml for 7, 14 days chronically and third group received Vit. C (0.15mg/100ml) along with lead acetate and result were analyzed for hematological parameter i.e....
4945
1222
IN VIVO TOXICOLOGICAL EVALUATION OF ORGANOPHOSPHATE PESTICIDE ON FEMALE ALBINO MICE: THERAPEUTIC EFFECTS OF CURCUMIN
Chlorpyrifos (CPF) an Organophosphate insecticide was evaluated for its potential to produce reproductive toxicity in rats following oral exposure. In the present study mice were given CPF at the dose level of 10 mg/kg body weight by Gavage method for 14 and 21 days. Morphological alterations of ovary were examined under LM. Its oxidative stress levels were also evaluated by Lipid peroxidation lev...
2814
1193
STUDY OF ANALGESIC ACTIVITY OF LITSEA GLUTINOSA (L.) ETHANOLIC EXTRACT ON SWISS ALBINO MICE
Aim: Litsea glutinosa (L.) a medicinal plant is popularly used as herbal remedy for various ailments. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was designed to evaluate analgesic potential of the ethanolic extract of the bark of the plant. Approach: The analgesic activity of standard tramadol HCl was determin...
4334
1482
IN- VITRO EVALUATION OF ANTIOXIDANT ACTIVITY OF CURCUMA CAESIA ROXB.
This study was undertaken to examine the antioxidant activity of methanolic extract of rhizomes of Curcuma caesia using DPPH free radical scavenging assay. The IC50 (The concentration of sample required to scavenge 50% of DPPH free radical) was calculated by plotting graph between % inhibition vs concentration. The Butylated Hydroxytoluene was used as standard antioxidant in comparison to methanol...
3385
1318
ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF SELECTIVE COX-2 INHIBITOR WITH CONVENTIONAL NSAIDs
Objective: The selective COX-2 inhibitor has high cardiovascular side effects, with low GI side effects, as compare to the conventional NSAID and it is proved that low dose of any drugs is always good for the health due to chances of less adverse effects. So the main objective of this research work is to lower the dose of selective COX -2 inhibitor, combine with a conventional NSAID and find out t...
4141
1072
PHARMACOGNOSTIC STANDARDISATION OF THE LEAVES OF PIMENTA DIOICA LINN.
Pimenta dioica commonly known as Allspice was used by early Central American civilizations as a flavoring for chocolate and found to have good anti-microbial action. The current study was therefore carried out to provide requisite pharmacognostic details about the plant. The results of the study could be useful in setting some diagnostic indices for the identification and preparation of a monograp...
3170
1187
BIOCHEMICAL CHARACTERISATION OF PHOSPHO BACTERIUM ISOLATED FROM RHIZOSPHERE OF COSTUS SP. WITH SPECIAL REFERENCE TO BACILLUS SPECIES
Soils generally contain adequate amount of inorganic and organic phosphorous but most of these remain unavailable to plants. The efficiency of water soluble phosphorus alone is usually low and soluble phosphorus when added to soil along with phosphate solubilizing microorganisms indicates utilization. The presence of soil microorganisms capable of transforming insoluble phosphorus to soluble form ...
2984
1254
ANTIBACTERIAL PROPERTIES OF TRADITIONALLY USED MEDICINAL PLANTS FOR ENTERIC INFECTIONS BY ADIVASI’s (BHUMKA) IN MELGHAT FOREST (AMRAVATI DISTRICT)
Medicinal plants are a major source of therapeutic agents since time immemorial. Tribal and rural community from their parents on folklore medicines acquires incredible knowledge of phytomedicine in non-coded form. With the repeated discussions and consultations with Tribal and Bhumkas, we selected 36 different medicinal plants of 30 families used against enteric infections form Melghat forest (Am...
3766
1783
ANTIRHEUMATOID ACTIVITY OF AQUEOUS EXTRACT OF PIPER LONGUM ON FREUNDS ADJUVANT-INDUCED ARTHRITIS IN RATS
Aqueous extract of the fruits of the plant Piper longum was studied for their Anti rheumatoid activity in Freunds Adjuvant Induced Arthritis Rats with the dose of 200 and 400 mg/kg p. o. The administration of extract reported significant reduction in paw swelling on 4th, 8th, 14th and 21st day after sub-plenter administration of Complete Freunds adjuvant. The paw swelling was measured as a volume ...
4317
1431