Volume 12 (2021) - Issue 7, July
Considering the increasing trend of the cancer rate of numerous organs, efficient treatments are highly required to restrain human melanomas. Cancer is among the most prevalent illnesses ascertained in developed countries, estimating more than 1.50 million fresh instances in the US alone in 2017. Though, approximately most of the chemotherapeutic drugs presently on the market cause major adverse e...
RECENT DEVELOPMENT IN THE FORMULATIONS OF GINGER FOR THERAPEUTIC APPLICATIONS AND AN OVERVIEW TOWARDS THE ACTION ON SARS-COV-2
Ginger or Zingiber officinale, Roscoe of the Zingiberaceae family is a rhizome that is widely found and most consumed in South east Asian countries; also used as a traditional remedy to treat various ailments like nausea, vomiting, pain, arthritis, indigestion, gastro reflux, cardiovascular disease, diabetes, obesity, microbes, cancer, inflammation, oxidation, and wounds to name some of its activi...
ANGUISH OWED BY COVID-19 PANDEMIC: NEED OF CONSIDERATION TO BOOST IMMUNITY THROUGH FOOD HABITS AND AYUSH RECOMMENDATIONS
World Health Organization (WHO) designated the COVID-19 or more commonly called Coronavirus disease, a "public health emergency of international concern" on January 30, 2020, and declared it a pandemic on March 11, 2020, which threatens human wellbeing around the world. With no proven pharmacological treatment, therapy (such as plasma, bacteriophage, virophage) drug approved by Food and Drug Admin...
COVID-19 has been proved to create a pandemic over the world within a few years. All scientists and health workers are trying to develop an effective treatment with collaboration. Various strategies such as antiviral, antibacterial, and antimalarial drugs have been employed to treat COVID- 19, but they were found to relieve the symptoms only. The formation of various variants of the virus in vario...
Scopoletin (7-hydroxy-6-methoxy coumarin) is a phenolic coumarin isolated from many plants, known as an important compound of the phytoalexin group. This article is created to provide information regarding the synthesis and pharmacological activity of scopoletin. Scopoletin has been found in many plant species and isolated from various parts of the plant (roots, fruits, leaves, stems, etc.) such a...
Nanocochleate is a novel lipid-based drug delivery system in which the liposomal vesicles are converted into nanocochleate by the addition of Calcium divalent cation. This technology involves encochleation of the drug for overcoming problems such as poor solubility, poor permeability, and poor oral bioavailability. This novel lipid-based formulation approach is applicable for the category of drugs...
Inflammatory bowel diseases (IBD) are chronic and relapsing intestinal inflammatory conditions, hallmarked by a disturbance in the bidirectional interaction between gut and brain. IBD is Ulcerative colitis (UC) and Crohn‘s disease (CD). Conventional therapies are inadequate and are associated with several systemic side effects due to lack to localization of active moiety at the inflamed site. Tr...
Pectinases are the pectinolytic enzymes that constitute an important component of the plant cell wall and of wide use with their target as pectins. Pectinases cover three different enzymes: Pectin-esterases (PE) act upon ester bonds in pectin breaking them into simpler forms, Polygalacturonases (PG) target the bonds between the galacturonosyl residues, and Pectate lyases (PL) target the alpha 1,4 ...
Bhavaprakasha is unique in the sense that it shows the slow amalgamation of traditional Indian materiamedica with several new additions which came to the Indian subcontinent through trade and exchanges with foreign civilizations. The Nighantuportion of Bhavaprakasha is an excellent repertoire of herbs and minerals used in Ayurveda. Several plants with properties related to augmentation of ocular f...
PATHOPHYSIOLOGICAL ASSOCIATION OF COVID-19 WITH TYPE I DIABETES MELLITUS AND ASTHMA IN THE PEDIATRIC POPULATION AND ITS MANAGEMENT STRATEGY
Background and Aim: Coronavirus 2019 (COVID-19) is a pervasive emergency affecting 1-5% of children, among whom the majority are with preexisting comorbidities. This commentary aim is to highlight two such prominent childhood comorbidities, i.e., asthma and type 1 diabetes mellitus (T1-DM), with their pathophysiological link to COVID-19. Method: We searched the Google Scholar and PubMed databases ...
Sarcoidosis is a rare autoimmune inflammatory disease, which is difficult to diagnose due to a lack of approved clinical tests. It has been observed in each race, and highest among the Scandinavia, African-American but Asians are less vulnerable to it. It affects most prominently adults from the age group of 20 to 60. The main characterized symptom of this disease is non-caseating granulomas, spec...
The medicinal plant Ricinus communis is one of the effective plants which offer a solution to several kinds of diseases. Owing to this, the present research aims to review the medicinal properties of one of such common herbal plants, Ricinus communis, its possible role as herbal medicine, and assessment for pharma-covigilance. Related research articles were collected from Google Scholar, Pub Med, ...
IN-VITRO ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF AERIAL PARTS OF PRUNUS SPINOSA L. GROWING WILD IN BOSNIA AND HERZEGOVINA
Phytotherapeutical properties of blackthorn (Prunus spinosa L.) are well known and used in Bosnia and Herzegovina traditional medicine. This study aimed to investigate total phenolic content, total anthocyanin content, total flavonoid content, antioxidant and antibacterial activities of different ethanolic extracts from wild blackthorn flowers, leaves and fruits, obtained by microwave-assisted ext...
FORMULATION DEVELOPMENT OF DOLUTEGRAVIR SODIUM LOADED NANO LIPID CARRIERS FOR IMPROVED SOLUBILITY AND PERMEABILITY
Dolutegravir sodium (DTG) is a poorly soluble antiretroviral drug that belongs to BCS class II approved by the FDA for treatment of HIV infections; however, DTG has several shortcomings, including low solubility in water, low oral bioavailability, hepatotoxicity, and instability in an acidic environment. After oral administration, 84% of the dose is excreted from the body in an unchanged form due ...
β1-ADRENERGIC RECEPTOR POLYMORPHISMS AND RISK OF ATRIAL FIBRILLATION AFTER CARDIAC SURGERY IN IRANIAN POPULATION
Postoperative atrial fibrillation (POAF) is a frequent rhythm disturbance after cardiac surgery and is associated with poor cardiovascular outcomes. Beta-blocker therapy is an effective strategy to prevent or decrease the high incidence of POAF and β1-adrenergic receptor (β1AR) polymorphisms that affect the cardiac response to β1AR antagonists. The study objective is to analyze the association ...
Carbohydrate-based therapeutics are extremely potent, and many carbohydrate-based drugs are in the stage of preclinical or clinical trials. There is a growing interest in developing carbohydrate analogues for novel drug discovery as most of the recently used carbohydrate drugs display significant pharmacological activities and low toxicity. Also, the search for an antipyretic drug is a never-endin...
EVALUATION OF ANTIBACTERIAL ACTIVITY OF PENTABARK KASHAYA AGAINST SELECTED BACTERIAL STRAINS CAUSING WOUND INFECTION: IN-VITRO STUDY
Background: Wound infection occurs when one or more organisms invade the wound. Nosocomial infections are the most common hospital acquired infections responsible for mortality and morbidity. Multidrug resistance against bacterial strains is the most serious emerging situation in worldwide, warranting the search for other alternatives. In this regard Pentabark kashaya was developed which contains ...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING UPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF NETUPITANT AND PALONOSETRON IN CAPSULE
A simple, accurate, and precise stability-indicating method was developed for the simultaneous estimation of the Netupitant (NTPT) and Palonosetron (PLSN) in a capsule by UPLC. Chromatographic elution was processed through an HSS C18 (100 × 2.1 mm, 1.8m) reverse phase column, and the mobile phase composition of 0.01N KH2PO4 buffer (4.0 pH) and acetonitrile in the ratio of 55:45 was pumped through...
DEVELOPMENT OF STABILITY-INDICATING UPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF TIPIRACIL ANDTRIFLURIDINE IN FORMULATION
Aim of the present research work was to develop a sensitive, precise, and robust stability-indicating UPLC method for the simultaneous estimation of tipiracil and trifluridine in formulations. The chromatographic separation of a mixture of tipiracil and trifluridine was attained in isocratic method utilizing a mobile phase of 0.1% orthophosphoric acid: acetonitrile in the proportion of 50:50% v/v ...
ANTILITHIATIC ACTIVITY OF LEAF EXTRACT OF CITRUS MEDICA ON SODIUM OXALATE UROLITHIAIS–IN-VITRO AND IN-VIVO EVALUATION
Urolithiasis is a common urological disorder responsible for serious human affliction and cost to society with a high recurrence rate. The aim of the present study was to systematically evaluate the leaf extract of Citrus medica using suitable in-vitro and in-vivo models to provide scientific evidence for its antilithiatic activity. Cystone has been suggested to be beneficial in urolithiasis, as i...
ISOLATION, IDENTIFICATION AND SCREENING FOR BIOACTIVE COMPOUNDS WITH ANTIMICROBIAL ACTIVITIES FROM SUB-AERIAL CYANOBACTERIA OF EASTERN REGION, ODISHA
Background and Objectives: Cyanobacteria are rich in various bioactive compounds. This study aims to screen the antimicrobial activity of sub-aerial Cyanobacteria isolated from sub-aerial habitats (Old monuments and building facades). Materials and Methods: Crude aqueous and organic extracts were screened for phytochemical constituents and tested for their antimicrobial efficacy against human path...
Succinimide and its derivatives are important substitutes of many medicinal compounds in the pharmaceutical field. One of the essential objectives in heterocyclic and medicinal chemistry is the synthesis of molecules having importance as therapeutic agents. Heterocyclic compounds and their derivatives contain an imide ring that can easily cross biological membranes in-vivo. Mannich reactions are o...
ASSESSING PHARMACOTHERAPEUTIC MANAGEMENT OF ANEMIA IN VARIOUS STAGES OF CHRONIC KIDNEY DISEASE AND POST RENAL TRANSPLANT PATIENTS
Introduction: Anemia in CKD occurs when the kidneys are damaged or diseased. They cannot make enough EPO, which stimulates the bone marrow to produce RBC. It is associated with increased cardiovascular diseases, hospitalization, reduced quality of life, cognitive impairment, and mortality. Materials and Methods: A prospective observational study was conducted on CKD patients. Demographic details, ...
ANTIALZHEIMER ACTIVITY OF METHANOLIC EXTRACT OF BUCHNANIA LANZAN LEAVES BY USING BEHAVIOUR MODELS ON ALBINO WISTAR RAT
Objective: The key objective of the study is to evaluate the Anti-Alzheimer activity of methanolic extracts of buchnania Lanzan leaves by Aluminum Chloride induced Alzheimer's. Buchanania lanzan Spreng a well-known forest plant of the family Anacardiaceae. It is reported to have numerous uses in the indigenous system of medicine in India. Material and Methods: Albino Wistar rats were administered ...
HPTLC SCREENING OF AMINO ACID PROFILE OF CURCUMA SPECIES FROM MELGHAT FORESTS DIST. AMRAVATI MAHARASHTRA
Genus Curcuma L. ( Zingiberaceae), comprising of 120 species, is distributed throughout South and South-East Asia, with few species extending to China, Australia, and South Pacific. Four species of Curcuma are reported from Melghat. Of these C. longa L. is cultivated while C. inodora Blatt., C. pseudomontana J. Graham and C. decipiens are wild. C. decipiens being rare could not be collected. C...
EVALUATION OF ANTI-INFLAMMATORY AND ANTI-DIABETIC EFFECTS OF DIFFERENT FRACTIONS OF HOLARRHENA PUBESCENS (BUCH.- HAM.) WALL. SEED EXTRACT
Inflammation is a chemical-mediated defense mechanism of body. Inflammatory process is also associated with development of various diseases like rheumatoid arthritis, psoriasis, atherosclerosis, and diabetes. Diabetes mellitus is a most common and life-threatening health problem in today’s date. Several marketed anti-diabetic drugs are characterized with side effects. Hence there is a need to se...
Common chicory (Cichorium intybus L.) plant belonging to sunflower family primarily grown for its root which is used as a coffee substitute but is also widely used in folk medicine to treat various ailments ranging from wounds to diabetes. The plant is a good tonic cooling agent and is useful in headache, throat inflammation, immune stimulation, mutagenic, probiotic, hepatoprotective, antibact...
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDY OF RARE EARTH COMPLEXES OF SCHIFF BASE DERIVED FROM 4-AMINO-3-HYDROXY BENZOIC ACID
Schiff base was prepared by using 4-amino-3-hydroxy benzoic acid and 4-nitrobenzaldehyde, namely (E)-3-hydroxy-4-((4-nitrobenzylidene) amino)benzoic acid. In the preparation of rare earth complexes, nitrates of lanthanum, Cerium, and Praseodymium were used with Schiff base. Rare earth Schiff base complexes were prepared by using NaOH to maintain the pH of solvent. Synthesized Schiff base ligand an...
A STUDY OF ANALYTICAL METHOD DEVELOPMENT, VALIDATION AND FORCED DEGRADATION FOR SIMULTANEOUS ESTIMATION OF GLYCOPYRROLATE AND FORMOTEROL FUMARATE IN BULK DRUG BY UHPLC METHOD
The present study was proposed to develop a simple, rapid, and economical UHPLC method was described for the method development, validation and forced degradation for the simultaneous estimation of glycopyrrolate and formoterol fumarate in bulk drug. The chromatographic conditions were observed in the column using Zorbax RXC18 (150 × 4.6 mm) 5 µm using a mobile phase composition of Water: Aceton...
Background: Phytochemical profile and antioxidant studies are based on exploring plants for their use in the development of novel therapeutic drugs. Oroxylum indicum (OI), a valuable medicinal plant is native to India, found mainly in the Himalayan foothills and the Western Ghats. It has been used by traditional medicinal practitioners for a variety of ailments and is categorized as vulnerable med...
TO INVESTIGATE THE EFFECT OF SPAN 60 AND SPAN 80 POLYMER ON RELEASE RATE OF SIMVASTATIN NOISOME IN COMPARISON WITH PURE SIMVASTATIN
The main objective of the present study was to develop and evaluate the simvastatin noisome using different grades of nonionic surfactants. It was hypothesized that niosomes would increase in vitro release of simvastatin in comparison to the API Mumbai. Niosome were prepared by thin-film hydration method and evaluated for particle size, entrapment efficiency, PDI, and in vitro release. The differe...
The demand for herbal medicines is growing at a drastic rate due to their improved pharmacological actions, minimal side effects, and cost-effectiveness. The ever-increasing cost of chemotherapy ruined the economic stability of many families. This led to the discovery of herbal medicines for cancer treatment. Tribes of Western Ghats have been using the roots of Apama siliquosa for cytotoxic activi...
GC-MS METABOLITE PROFILING OF BIOACTIVE COMPOUNDS IN LEAF, FRUIT AND SEED EXTRACTS OF SYZYZIUM CUMINI (L.)
The present study aimed to explore the primary metabolites present in leaf, fruit, and seed crude extracts of Syzygium cumini L by Gas chromatography - Mass spectrometry. The compounds in the leaf, seed, and fruit extracts resulted from the GC-MS analysis was relevant to the National Institute of Standards and Technology (NIST) library. The metabolite profiling of the extracts revealed the presenc...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-UFLC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND METFORMIN HCl
A Simple, sensitive, precise, and stability-indicating method was developed for the simultaneous estimation of Telmisartan & Metformin HCl in bulk & prepared formulation. The column used for the separation was Phenomenex C18 (150 × 4.6, 5 µ), with a mobile phase containing Phosphate buffer pH 3.6 & acetonitrile (30:70% v/v) at a flow rate of 0.5 ml/min. The retention time of Telmisar...
ANTI-HYPERGLYCAEMIC EFFECTS OF AQUEOUS PREPARATION OF MEYNA SPINOSA ROXB. FRUIT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The unripe fruit of Meyna spinosa / Laxiflora is used for the treatment of diabetes by traditional healers. The effect of the aqueous extract of the fruit is investigated on the normal and elevated blood glucose level of the experimental animal rats. The blood glucose level of the rats is elevated with the administration of I.P streptozotocin. The estimation of the blood glucose level is done by u...
A RANDOMIZED SINGLE BLIND PLACEBO CONTROLLED CLINICAL STUDY TO EVALUATE EFFICACY OF AMALAKI (EMBLICA OFFICINALIS) EXTRACT CAPSULE ON ACNE VULGARIS ALONG WITH ITS ANTI-OXIDANT PROPERTY
Background and Objectives: Acne vulgaris is a chronic skin infection affecting the majority of teenagers and adolescents. It is a disease that affects almost 80% of individuals. Acne, by definition, is multi-factorial chronic inflammatory disease of the Pilosebaceous unit. Nowadays, herbal formulations are gaining popularity in the treatment of various diseases. By considering this fact, the prese...
The whole plant of Hedyotis herbacea Linn. which was claimed to have wound healing activity, was evaluated for phytoconstituent ursolic acid determination. The literature review suggests that ursolic acid was scientifically validated for wound healing activity. So the research work aims to screen the various extract of H. herbacea to determine the ursolic rich fraction. So a high-performance thin-...
A STUDY OF EPIDEMIOLOGICAL, ETIOLOGICAL AND CLINICAL FACTORS IN HYPER-PIGMENTATION POPULATION IN NORTH GUJARAT
Background: Hyperpigmentation (HP) is a common dermatological disease. Indian population presents in a variety of dermatological pigmentation. Effects of Nutrients and metabolites factor are important for skin hyperpigmentation condition. Aims and Objectives: In this study, we aimed to evaluate the status of Haemoglobin, vitamin B12, Ferritin, and TSH levels in people with hyperpig-mentation from...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF LEDIPASVIR AND SOFOSBUVIR IN FIXED DOSAGE FORM
Ledipasvir and Sofosbuvir Combination have been approved for the treatment of Chronic Hepatitis C Viral Infection. Here an accurate, valid, elementary, and error-free reverse-phase liquid chromatography strategy was developed for the quantitation of Ledipasvir and Sofosbuvir in its bulk form as well as in fixed dosage form. Effective chromatographic separation of Ledipasvir and Sofosbuvir was achi...
EVALUATION OF METHANOL EXTRACT OF ALOYSIA GRATISSIMA VAR. GRATISSIMA LEAVES ON BEHAVIOR AND ANXIETY IN MICE
Anxiety disorders are among the most prevalent and high-cost diseases. Medicinal plants are a very good option to treat, and several have shown the ability to reduce anxiety. We report here the effect of A. gratissima var. gratissima (Agg) on behavior and anxiety in mice. The methanol extract of leaves was tested in order to verify the safety, effect on sleeping time and behavior. Anxiety was test...
Ophthalmologists generally treat ocular infections by giving prophylactic anti-microbial therapy as they do not have data from culture analysis. The indiscriminate use of anti-microbials can lead to drug resistance, difficulty in treating infections, and increased chances of severe ocular damage. The purpose of this study was to analyze the utilization of anti-microbial drugs in the ophthalmology ...
IN-VITRO ANTI-BACTERIAL POTENCY AND PHYTOCHEMICAL ANALYSIS OF ANACARDIUM OCCIDENTALE L. LEAF AGAINST SOME GASTROINTESTINAL TRACT INFECTION-CAUSING BACTERIA
Bacterial infections are one of the prominent causes of health problems and mortalities around the world. Medicinal plants are a rich source of antimicrobial agents and provide a safer and cost-effective way of treating bacterial infections. The objective of the present investigation was to evaluate the anti-bacterial potential of petroleum ether and methanol extracts of Anacardium occidentale L. ...
FORMULATION AND EVALUATION OF SUSTAIN RELEASE MATRIX TABLET OF FLUVOXAMINE MALEATE USING MORINGA OLEIFERA GUM
Fluvoxamine Maleate, an oral serotonin reuptake inhibitor, has been used widely for the treatment of anxiety. Sustained-release matrix-type drug delivery system has advantages over conventional modes of drug administration, enhancing drug bioavailability as it avoids the first-pass metabolism and improves patient compliance. Optimization of the formulation was performed by varying the concentratio...
Atorvastatin calcium is a synthetic lipid-lowering agent used in hyperlipidemia. An oral dose of Atorvastatin calcium ranges from 10mg to 80mg per day. Atorvastatin calcium belongs to BC’s class II drug having low solubility and high permeability. The absolute bioavailability of Atorvastatin calcium is approximately 12%, and the systemic availability of HMG-CoA reductase inhibitory activity is a...
Several spectrophotometric and HPLC methods for the determination of lornoxicam and eperisone hydrochloride have been documented individually or in combination with other drugs in pharmaceutical dosage forms. Therefore, in the present study, a reasonable and practical reverse phase HPLC method was developed and validated for lornoxicam and eperisone hydro-chloride in bulk formulation. In RP-HPLC ...
Linalool is the first ingredient to synthesize many other substances of higher value for the pharmaceutical and fragrance industry; therefore, finding sources of essential oils containing Linalool is an important and necessary task. The purpose of this study is to investigate Linalool of plants containing essential oil in Vietnam to extract Linalool sources for the pharmaceutical and fragrance ind...
SYNTHESIS, IN-VITRO ANTIMICROBIAL EVALUATION AND MOLECULAR DOCKING STUDIES OF SOME NOVEL ACETOPHENONES SUBSTITUTED QUINOXALINE THIOSEMICARBAZIDE DERIVATIVES
In the present research worked aims to increase the antimicrobial activity of quinoxaline thiosemicarbazide derivatives by substitution of some acetophenones and their antimicrobial evaluation against various antimicrobial strains with molecular docking studies. Lead molecule (1E, 4E)-1-(7-chloro-3-isopropylquinoxalin-2(1H)-ylidene) thiosemicarbazide was synthesized and condensed with various subs...
This study was conducted to investigate the antibacterial activity and rate of kill of the various partially purified fractions of Spondias mombin’s leaf extract on selected pathogenic bacteria. Fresh leaves of Spondias mombin were air-dried and then ground into fine powder. The powdered leaves of Spondias mombin were extracted using ethanol-water in the ratio 1:1 (v/v). The crude extract was fr...
APPLICATION OF ANALYTIC NETWORK PROCESS: WEIGHTING OF SELECTION CRITERIA TO SELECT THE SUITABLE METHOD FOR THE PREPARATION OF NANOCRYSTALS
This article presents a logical technique to select the best method for the preparation of nanocrystals by implementing the analytic network process. One of the most significant decision-making tools to make excellent decisions is Analytic Network Process which includes Model construction, Paired assessments between each two clusters or node, Super matrix assessment based on outcomes from paired c...
TOXICITY AND ANTIHYPERTENSIVE ACTIVITY OF LIPPIA MULTIFLORA EXTRACTS IN THE DIFFERENT REGIONS OF BENIN
The objective was to study the antihypertensive effects of the aqueous decoctycrude of Lippia multiflora from the region of Djidja at a dose of the plant as well as the effects of this extract on some biochemical parameters in the rat were made hypertensive by 500 mg/kg of body weight during the 14 days and were treated with losartan potassium at a dose of 100 mg/kg of body weight, of L-NAME at a ...
A stability-indicating method by UV spectrophotometry has been developed for the specific determination of Amorolfine HCl in bulk in the presence of its degraded products. The method is simple, accurate, precise, and robust. Experiments were designed for determining linearity, the limit of detection and quantitation, accuracy, precision, and specificity of this analytical method as per the Interna...
ASSESSMENT OF CAUSALITY, SEVERITY AND PREVENTABILITY OF ADVERSE DRUG REACTIONS OF CANCER CHEMOTHERAPY IN A TERTIARY CARE TEACHING HOSPITAL, GUJARAT, INDIA
Background: To evaluate the various adverse drug reactions with different cancer chemotherapy regimens, severity, causality assessment and preventability. Methods: This cross-sectional, observational study was carried out in the oncology department at a tertiary care teaching hospital over a period of one year. Data on Adverse Drug Reactions (ADRs) of anticancer drugs were collected of cancer pati...
Nail plate being a formidable barrier, drug permeation through this layer is limited. Taking this as a challenging task, the present study focuses on the formulation of an antifungal topical nail lacquer using Oxiconazole nitrate. The novelty of the studies can be stated as the use of a combination of permeation enhancers like salicylic acid, thioglycolic acid, and urea for effective therapeutic t...
METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND VELPATASVIR BY UV-VISIBLE SPECTROPHOTOMETRY
A simple, linear, precise, and economical UV spectro-photometric method has been developed for the simultaneous estimation of sofosbuvir and velpatasvir in the bulk and pharmaceutical dosage form. The standard stock solutions were prepared by using methanol as solvent. Estimation of sofosbuvir and velpatasvir was conducted by using a simultaneous equation method based on the measurement of Maximum...
ISOLATION AND PURIFICATION OF NIMBIDIN FROM AZADIRACHTA INDICA OF WESTERN GHATS AND EVALUATE ITS ANTIOXIDANT, ANTI-BACTERIAL AND ANTI-DIABETIC PROPERTIES
Azadirachta Indica has always been known to be the bestowed with good health for many centuries in India. It has been found that the Neem is native to Asian countries. There are three major active components in A. indica, namely nimbin, nimbidin, and nimbiene. The compound nimbidin was isolated by chromatographic techniques. A. indica leaves extract was prepared, and the phytochemical analysis was...
TEMPERATURE DEPENDENT BIOCONVERSION OF WASTE PAPER BY GARDEN SNAIL (CORNU ASPERSUM) CELLULASE INTO GLUCOSE A FEEDSTOCK FOR BIO-PRODUCT DEVELOPMENT
The global production of solid waste and lack of its management is a concern for many global populations. Also of major concern is the production of fossil fuel-based materials and substances such as medicines. Another unease observation is the destructive action of garden snails on plant materials, of which many are found in gardens and fields of farmers. The search, however, continues for proced...
EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF CETIRIZINE AND LEVOCETIRIZINE: AN EXPERIMENTAL STUDY
Aim of the study: To evaluate analgesic and anti-inflammatory activities of cetirizine and levocetirizine in different experimental models in rats. Materials and Methods: Analgesic activity of cetirizine and levocetirizine was assessed in tail flick model in rats (n = 6), where it was compared with aspirin and tramadol. Reaction time in seconds was used as the unit for measurement of pain and an i...
The aim of this study was to synthesize the graft copolymer of starch to obtain materials that profit from the particular properties of both natural and synthetic polymeric material. Thus in the present work, a graft copolymer of methyl acrylate and potato starch has been synthesized under microwave irradiation using K2S2O8-TU redox pair, which generates free radical sites on the starch backbone w...
Rivastigmine is used for the treatment of mild to moderate dementia of the Alzheimer’s type. Transdermal delivery of Rivastigmine is preferable to improve gastrointestinal tolerability. A novel transdermal system with zero-order release kinetics was developed following a hybrid technique in a combination of the micro reservoir and adhesive dispersion system. The transdermal system was prepared b...
The objective of research work is to formulate a venlafaxine HCl containing medicated chewing gum that has greater bioavailability and compliances than conventional treatment strategies. The four different formulations were prepared after some trial batches, containing different concentrations of the gum base and sucrose (MCG- I- MCG- IV). These batches were optimized on basis of softness and swee...
Microbial inulinases have a great potential for industrial use in the production of fructose from inulin. Optimization of the growth parameters of the microbes is essential to obtain inulinase in sufficient quantity. The present work aims to obtain inulinase from different fruits of endophytic bacteria and optimize its growth parameters. In a total of 22 isolates and among them, each one isolates ...