Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
FORMULATION AND EVALUATION OF DICLOFENAC POTASSIUM MATRIX TABLETS
The objective of the study was to develop HPMC matrix tablets for oral controlled/ sustained release of water soluble Diclofenac Potassium. Sustained release matrix tablets containing 100 mg of Diclofenac Potassium were developed using different drug polymer ratio of HPMC. Tablets were prepared by direct compression. Compressed tablets were evaluated for uniformity of weight, content of active ing...
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1578
STUDIES ON THE ANTI- INFLAMMATORY PROPERTIES OF CURCULIGO ORCHIOIDES GAERTN. ROOT TUBERS
In this study, the anti-inflammatory effect of methanolic extract obtained from root tubers of plant Curculigo orchioides Gaertn. (Amaryllidaceae) was investigated. The effect of extract was studied in Carrageenan induced rat paw oedema. The extract at a dose of 200mg/kg and 400mg/kg was carried out for the investigation. The results indicate that methanolic extract, at the dose of 200mg/kg & ...
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1515
A REVIEW ON ETHANOMEDICINAL USES AND PHYTO-PHARMACOLOGY OF ANTI-INFLAMMATORY HERB VITEX NEGUNDO
Vitex negundo is an important medicinal plant with potent anti-inflammatory activity. The major constituents of this plant are flavonoids, casticin, chryso-splenol and vitexin, Chrysophenol D, nishindine and hydrocotylene. It also contains monoterpenes agnuside, eurostoside, and aucubin. These constituents contribute various pharmacological activities as anti-inflammatory, antioxidant, antinocicep...
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1912
1, 2, 4-TRIAZOLES: AS BIOLOGICALLY IMPORTANT AGENTS
The chemistry of heterocyclic compounds containing five membered 1, 2, 4-triazole nucleus has been an intresting field of study for past few decades. The five membered 1, 2, 4-triazole ring exists in two tautomeric forms i.e., 1H-1, 2, 4-triazole, 4H-1, 2, 4-triazole collectively known as s-triazoles. The s-triazole derivatives possess extensive spectrum of biological activities such as antibacter...
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DEVELOPMENT AND IN VITRO EVALUATION OF MICRONIZED SUSTAINED RELEASE MATRIX TABLET OF CARVEDILOL
Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the technological procedures to improve the dis...
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IN-VITRO EVALUATION OF CLITORIA TERNATEA STEM EXTRACT FOR ANTIOXIDANT PROPERTY
Antioxidants are compounds that protect cells against the damaging effects of reactive oxygen species which can neutralise free radicals before they can do harm and may help undo some damage already caused to specific cells. Studies subject that several natural products possessing antidiabetic, antitumor and also flavonoids containing drugs can also act as antioxidants. Ayurveda and various tradit...
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ANTI-DIARRHOEAL ACTIVITY OF METHANOLIC EXTRACT OF ROOT BARK OF AILANTHUS ALTISSIMA SWINGLE (FAMILY: SIMAROUBACEAE) ON EXPERIMENTAL ANIMALS
Ailanthus altissima Swingle (Simaroubaceae) is commonly known as “Tree of heaven”. The methanolic extract of root bark of A. altissima (MEA) was taken for anti-diarrhoeal activity. Investigations were carried out on castor oil induced diarrhoea and small intestine transit method on mice. In former method, MEA 200 (mg/Kg) were reducing the total weight of the faeces of group (0.163±0.028) in c...
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DESIGN AND EVALUATION OF SOLID DISPERSED TADALAFIL TABLETS
Tadalafil (TD), a PDE-5 inhibitor, belongs to BCS class II. It is poorly soluble in water and requires enhancement in solubility and dissolution rate for increasing its oral bioavailability. In the present investigation, solid dispersed systems of tadalafil with poloxamer188 and sodium starch glycolate were prepared using solvent evaporation technique. The dissolution rate of the drug and poloxame...
5404
1934
IN VITRO EVALUATION OF ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF SERIES OF NEW PYRAZOLE DERIVATIVES; A STUDY ON THE STRUCTURE-ACTIVITY RELATIONSHIP
In present study, a series of new synthesized condensed pyrazole derivatives 1a-f have evaluated in vitro for their antioxidant activity, reducing power ability, antibacterial activity against Gram-positive and Gram-negative organisms and antifungal activity against different organisms. Minimum inhibitory concentration against the bacterial and fungal strains was determined. The study provides the...
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DEVELOPMENT OF VALIDATED HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF FEXOFENADINE HYDROCHLORIDE AND MONTELUKAST SODIUM IN TABLET DOSAGE FORM
A simple, fast and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Fexofenadine hydrochloride (FEXO) and Montelukast Sodium (MONT). Efficient chromatographic separation was achieved on phenomenex C18 column (150mm x 4.6 mm, 5 μm) as stationary phase with a mobile phase comprising of 0.5% Orthophosphoric acid pH adju...
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