Volume 16 (2025) - Issue 2, February
Review Articles
MICROSCOPIC CHARACTERIZATION, TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGY OF NYCTANTHES ARBOR-TRISTIS: AN UPDATED SYSTEMATIC REVIEW
Introduction: Being an Oleaceae family member, Nyctanthes arbor-tristis, known as Night jasmine or Harashingar, is a legendary plant with enormous therapeutic potential. Research on the different plant parts, such as the leaf, flower, fruit, seed, and bark revealed the phytochemicals that were responsible for the primary pharmacological activities. These phytochemicals included glucose, oleanic ac...
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EFFICACY AND SAFETY PROFILE OF DPP-4 INHIBITORS AS ADD-ON THERAPY IN PATIENTS WITH TYPE 2 DIABETES: A COMPREHENSIVE REVIEW
Aim: This study aimed to evaluate the efficacy and safety profile of DPP-4 inhibitors as add-on therapy in patients with type 2 diabetes. The study is important because DPP-4 inhibitors have been widely prescribed, and understanding their comprehensive effects is essential for better patient outcomes. Methods: An extensive literature search has been conducted using multiple databases, such as PubM...
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UNLOCKING COLD SECRETS; PSYCHROPHILES AND THEIR BENEFITS IN FOOD TECHNOLOGY
Psychrozymes, a diverse set of cold-active enzymes produced by psychrophiles including β-galactosidases, pectinases, and amylases which are examined for their specific benefits across various food processing domains. An in-depth exploration of psychrophiles in cold fermentation processes reveals their pivotal role in shaping the sensory attributes of fermented foods and beverages. Psychrophiles c...
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MILLET FOOD WASTE AS MEDICINE FOR MANAGEMENT OF LIFESTYLE DISORDERS
Plant foods are wasted especially in millets as they are not required in that particular product processing. From the cultivation of millet to its processing and consumption of the final product, a significant amount of waste is generated. Wasted foods are not spoilt foods and still have the potential to be used for the second time as food. But unfortunately, the fate of waste is always landfill...
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SELF–MICROEMULSIFYING DRUG DELIVERY SYSTEM: SPECIAL EMPHASIS ON VARIOUS SURFACTANTS USED IN SMEDDS
The majority of novel chemical entities getting discovered are having low water solubility and it must be addressed to distribute the drug more effectively. SMEDDS, a lipid-based drug delivery approach, is thought to boost oral absorption of less hydrophilic drugs. Surfactants are the major excipients used in SMEDDS as they are responsible for the emulsification process. The two main criteria whil...
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MICROBES MATTER: A REVIEW ON THE CURRENT UPDATES OF GUT MICROBIOTA IN RELATION TO AUTISM
Microbiota, in simple terms means the community of microorganisms, whereas microbiome means the whole genomes of the microorganisms in a particular environment. We humans consist of a large microbiome within as well as on body, most in the gut. The gut microbiota in human plays significant role in different aspects such as in human metabolism, nutrition, physiology, immune function, and various ot...
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COMPREHENSIVE REVIEW OF AUTOIMMUNE HEPATITIS: DIAGNOSTIC APPROACHES AND TREATMENT MODALITIES HIGHLIGHTED BY A CASE REPORT
Autoimmune hepatitis (AIH) is a chronic liver disease characterized by immune system dysfunction, elevated gamma globulins, and specific auto antibodies. It arises from genetic predisposition, environmental triggers, and immune dysregulation, and is typically managed with immunosuppressive therapy. The research highlights AIH risks, including disease recurrence and complications from vaccinations ...
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MARINE-DERIVED INGREDIENTS AND THEIR POTENTIAL USE IN SKIN-LIGHTENING AND COSMETIC FORMULATIONS
The advancement and changes in the pharmaceutical and cosmetic industry are governed utilizing the interests of clients for biologically energetic elements obtained naturally in place of synthetic manufacture and resources. One such novel technique within the beauty enterprise is using marine life as a supply of active components like micro and macroalgae, sea corals, marine bacteria, and seaweeds...
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STRENGTHENING IMMUNIZATION SYSTEMS THROUGH EFFECTIVE SUPPLY CHAINS: INSIGHTS FROM GLOBAL EFFECTIVE VACCINE MANAGEMENT INITIATIVE
The Expanded Programme on Immunization (EPI), launched in 1974, is the world’s major vaccination program against vaccine preventable diseases. Despite progress, the program’s success, measured through coverage rates, has recently stalled, especially in low-income countries where access to vaccines remains challenging. EPI’s effectiveness relies heavily on the Immunization Supply Chain, but t...
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Research Articles
DIRECT ACTIVATOR OF AMPK FROM SHILAJIT: A BIOINFORMATICS-BASED STUDY
Metabolic syndrome is continuously on the rise, due to a changed lifestyle and long ageing. The abnormal function of mTOR/AMPK, a cellular energy switch, is the main cause behind this pathogenesis, which is now defined as “metabolic syndrome”. Here, we have screened the metabolites of shilajit, obtained from the HRAMS analysis, to select the direct activators of AMPK, by using computational ex...
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IN-SILICO ANALYSIS OF PHYTOCHEMICALS FROM GINKGO BILOBA AND AEGLE MARMELOS AGAINST ALLERGIC CONJUNCTIVITIS
Allergic conjunctivitis (AC) is a prevalent ocular condition characterized by inflammation of the conjunctiva due to allergen exposure, resulting in itching, redness, and discomfort. Traditional medicinal plants such as Ginkgo biloba and Aegle marmelos have been recognized for their potential anti-inflammatory and anti-allergic properties. In this study, we conducted an in-silico analysis to explo...
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GENDER-BASED DISPARITIES IN GENE EXPRESSION AND MUTATION PROFILES IN ORAL SQUAMOUS CELL CARCINOMA REVEALED BY THE WHOLE EXOME SEQUENCING AND RNA SEQUENCING
Head and Neck Squamous Cell Carcinoma (HNSC) is a fast-growing form of cancer. This cancer originates in the squamous cells of the mouth and throat and primarily affects individuals who engage in risky lifestyle choices such as tobacco and alcohol consumption. The poor prognosis and high mortality rate of HNSC underline the urgent need for extensive research and novel treatment approaches. This co...
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PHYTOCHEMICAL ANALYSIS AND ANALGESIC ACTIVITY OF THE EXTRACT OF PROSOPIS JULIFLORA
Background: In dry and semi-arid regions of the world, Prosopis juliflora is one of the most significant tree species both commercially and environmentally. Leguminosae (Fabaceae) is the family to which Prosopis juliflora belongs. Aims and Objectives: To evaluate the analgesic activity of methanolic extract of dried leaves of Prosopis juliflora Linn. Materials and Methods: In this investigation, a...
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HEPATOPROTECTIVE EFFECT OF METHANOL EXTRACT OF CANNA INDICA ROOT ON PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS
Liver is an important organ and a central one for many of the metabolic functions of the body, decomposition of toxic and waste substances, and disposal of harmful substances from the body. Liver illnesses are still the serious problem of human health. Canna indica commonly known as an Indian shot, extensively used as a nutritive agent & has a number of valuable pharmacological activities. Peo...
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EXTRACTION OF FUCOXANTHIN FROM SARGASSUM WIGHTII, FTIR SPECTRA AND IT’S ANTIOXIDANT AND ANTIBACTERIAL PROPERTIES
Sargassum wightii,a seaweed and a marine macroalgae, is known to offer numerous health benefits, and compounds isolated from it are observed as the alternative to conventional treatment as an affordable plant-derived drug. In the present study, the bioactivity of the two fractions from Sargassum wightiiw as derived using two different solvents, methanol and acetone: methanol. Acetone: Methanol fra...
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EVALUATION OF ANTI-SEIZURE ACTIVITY OF ETHANOLIC EXTRACT OF MUSA PARADISIACA FLOWER ALONE AND IN COMBINATION WITH ANTI-SEIZURE DRUGS IN SWISS ALBINO MICE
Background: There are numerous anti-seizure drugs on the market, but side effects at the highest dosage that can be tolerated account for the majority of prescription discontinuations. Research on Musa paradisiaca's synergistic activity is of utmost importance in getting insight into its anti-seizure potential. Methods: Anti-seizure activity of Musa paradisiaca on generalized tonic-clonic seizure ...
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VALIDATED RP-HPLC ASSAY METHOD FOR DETERMINATION OF ACALABRUTINIB IN PHARMACEUTICAL FORMULATION BY QBD APPROACH
A method by using a quality-by-design approach for the development and validation of an RP-HPLC method for determination of Acalabrutinib in API and marketed formulation. Chromatogram was run through SunFire C18 Column, 100Å, 10 µm, 4.6 mm X 150 mm. Mobile phase containing 0.1% OPA: Ethanol and water (50:50) taken in the ratio 60: 40 (%v/v) was pumped through the column at a flow rate of 1.0 ml/...
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EFFECTIVENESS ANALYSIS OF ANTIDEPRESSANTS IN THE MAJOR DEPRESSIVE DISORDER: A PROSPECTIVE OBSERVATIONAL STUDY
Background: Major Depressive Disorder (MDD) is a severe psychiatric illness characterized by persistent sadness, loss of interest, lack of energy, disturbed sleep and suicidality with lifetime prevalence rate for MDD is 16.2%. Treatment options for depression include medication, primarily antidepressants, and psychotherapy. Method: A prospective observational questionaire based study was conducted...
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METHOD DEVELOPMENT AND MODEST VALIDATION OF SULFADIAZINE BY REVERSE PHASE HPLC
Sulfadiazine belongs to a class of sulphonamide antibiotics. Sulfadiazine is a synthetic bacteriostatic sulphonamide that exhibits a broad spectrum of activity against gram-positive and gram-negative pathogens. The Sulfadiazine antibiotic is a member of the Sulfa drugs class. This drug is utilized for bacterial infections in the brain, ears, and urinary tract. The primary goal of the research is t...
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GREEN SYNTHESIS OF SILVER NANOPARTICLES FROM THE LEAF EXTRACT OF DENDROPHTHOE FALCATA (L.F.) ETTINGSH: PHYTOCHEMICAL ANALYSIS AND BIOACTIVITY STUDIES
An evergreen semiparasitic plant belonging to the Loranthaceae family, Dendrophthoe falcata (L.f.) Ettingsh is common throughout India and feeds on a variety of host species. The potential of silver nanoparticles (AgNPs) produced by D. falcata-mediated processes is still unknown, despite the known bioactivity of D. falcata extracts. The present investigation examines the phytochemical profile of l...
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PHYTOCHEMICAL ANALYSIS AND EVALUATION OF IN-VITRO ANTIOXIDANT ACTIVITY OF CLASSICAL SIDDHA HERBAL FORMULATION ¬‘THURINJI MANAPAGU’ (CITRUS MEDICA SYRUP)
Siddha science is an ancient way of healing which uses plants, minerals and metals for medicinal preparation. Research on herbs is gaining significant interest for discovering new drug molecules. In this context, it is essential to investigate the numerous traditional formulations documented in classical Siddha literature. The Thurinji manapagu contains Citrus medica and Saccharum officinarum is a...
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MINIMUM INHIBITORY CONCENTRATION OF VANCOMYCIN AMONG METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES FROM A TERTIARY CARE CENTRE
Introduction: Infections due to methicillin resistant Staphylococcus aureus (MRSA) are increasing worldwide. Vancomycin is considered as the drug of choice to treat serious infections caused by MRSA strains. The emergence of S. aureus isolates with intermediate and complete resistance to vancomycin in the past two decades is a major public health concern. Aim and Objectives: To determine the MIC ...
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DEVELOPMENT AND EVALUATION OF NATURAL ANTI-DANDRUFF SHAMPOO
The objective of this study is to develop and assess an herbal anti-dandruff shampoo that emphasizes safety and efficacy through the use of natural ingredients. Recognizing that healthy, vibrant hair is a key element of beauty, this shampoo is designed to effectively cleanse dirt and dandruff, promote hair growth, enhance lustre, and strengthen and darken the hair. Given the shampoo sector's signi...
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ANTIDIABETIC POTENTIAL OF ETHANOLIC EXTRACT OF FLOWER OF PETUNIA HYBRIDA IN RODENT
The present work focused on preparing ethanolic extract of Petunia hybrida and evaluating its anti-diabetic potential in rats. The extraction of flowers was carried out using ethanol and the extraction yield was found to be 21.7% w/w. The total phenolic content of ethanolic extract of Petunia hybrida was found to be 39.18±1.46 GAE mg/g. The antidiabetic action of the extract was evaluated in term...
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TOOTH HEMISECTION RATHER THAN EXTRACTION OF A MUTILATED MOLAR-A 2 YEAR FOLLOW UP CASE REPORT
Modern breakthroughs in dentistry have created the opportunity for people to maintain a functional dentition for lifetime. Hemisection is a conservative approach of maintaining tooth. This is an endodontic treatment that involves removing one or more roots as well as the current crown structure in order to promote tooth retention and address nonfunctional dental roots that cannot be maintained. As...
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A STUDY TO EVALUATE THE PREVALENCE AND PRESCRIPTION PATTERN OF ACUTE GASTROENTERITIS IN PAEDIATRIC PATIENTS IN A TERTIARY CARE HOSPITAL
Background: Acute gastroenteritis is usually considered - a benign disease, remains a major cause of pediatric morbidity and mortality around the world. Materials and Methods: An observational cross-sectional study conducted in indoor / outdoor patient department of Pediatrics in Government Medical College and Rajindra Hospital, Patiala for 6 months. Demographic data and complete prescriptions of ...
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INSIGHTS INTO MALE INFERTILITY MANAGEMENT: EXPERT OPINION AND PRACTICES AMONG LEADING GYNECOLOGISTS IN INDIA
Background: Male infertility is a significant, yet often overlooked, contributor to couple infertility, particularly in developing countries. Social stigma, cultural barriers, and lack of comprehensive data on male infertility further exacerbate the issue, making it challenging to address effectively. Aims and Objectives: This study aimed to evaluate the current clinical practices, diagnostic appr...
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EFFICACY OF CAUDAL ROPIVACAINE WITH KETAMINE VERSUS ROPIVACAINE WITH MIDAZOLAM FOR ANALGESIA IN PEDIATRIC INFRAUMBILICAL SURGERY
Aim: This study aimed to compare the analgesic efficacy of caudal ropivacaine and ketamine with ropivacaine and midazolam in paediatric patients undergoing infraumbilical surgery. Material and Methods: A study was conducted involving a group of 100 paediatric patients who underwent infraumbilical surgery. The study participants were divided into two groups: Group A received 1.0 ml/kg of 0.15% ropi...
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USE, STORAGE, & DISPOSAL OF UNUSED MEDICINES AMONG MEDICAL STUDENTS: A SURVEY-BASED STUDY
Introduction: The increase in drug consumption in India has resulted in significant health hazards due to improper consumption, storage, and disposal practices among the general population. This study aims to evaluate the awareness and practices of medical students regarding the consumption, storage, and disposal of unused and leftover medications at their homes. Materials and Methods: A questionn...
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AMLODIPINE-INDUCED GINGIVAL HYPERPLASIA IN CHRONIC PERIODONTITIS: A CLINICAL CASE REPORT WITH ONE YEAR FOLLOW-UP
Background: Drug-induced gingival overgrowth (DIGO) is a common side effect of certain medications used for non-dental purposes, notably anticonvulsants, calcium channel blockers (CCBs), and immunosuppressants. These drugs, despite differing pharmacologically, inhibit intracellular calcium ion influx, leading to a decrease in collagenolytic activity and an increase in fibroblasts and collagen synt...
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ROLE OF HYSTEROSCOPY IN PATIENTS WITH ABNORMAL UTERINE BLEEDING AND ITS HISTOPATHOLOGICAL CO-RELATION
Introduction: Abnormal uterine bleeding (AUB) is a common gynecological concern that presents significant diagnostic challenges, particularly because it encompasses a wide range of possible underlying causes, from benign conditions like polyps and fibroids to more serious pathologies such as endometrial cancer. This study aimed to assess the diagnostic accuracy of hysteroscopy in AUB and its conco...
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THE IMPACT OF REMNANT CHOLESTEROL AND LIPID PROFILE DISCORDANCE ON CAROTID INTIMA-MEDIA THICKNESS AMONG INDIAN PATIENTS WITH CORONARY ARTERY DISEASE: AN EXPLORATORY OBSERVATIONAL STUDY WITH ADVANCED REGRESSION ANALYSIS
Background: Residual cardiovascular risk persists despite optimal LDL-C lowering, suggesting that remnant cholesterol (RC) may contribute to atherosclerosis. Objective: To evaluate the association between RC, lipid profile discordance, and cIMT, and determine if RC and lipid discordance are independent predictors of increased cIMT after adjusting for traditional cardiovascular risk factors. Method...
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