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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 12 (2021) - Issue 3, March

Review Articles

 
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1.

CORONAVIRUS TO COVID-19 PANDEMIC: AN OVERVIEW

Coronaviruses wrapped with the layers of positive-sense RNA viruses specified by the club-like projections from their surface responsible for a variety of diseases in the animal kingdom. After the two historical episodes of coronaviruses i.e., severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, this time world strike...

M. Rana, S. Singla, P. Jaswal and G. Singh *

Department of Pharmacology, University School of Pharmaceutical Sciences, Rayat Bahra University, Mohali, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1332-41

1332-1341

849

592

2.

POTENTIAL ACTIVITY OF SPICES ON ACE2 EXPRESSION – A MINI REVIEW

Spices, nature's gift to mankind are the reservoir of secondary metabolites – alkaloids, flavonoids, saponins, tannins, glycerides, sulfides, and other oxygen/nitrogen compounds that can effectively treat viral infections, bacterial infections, and respiratory problems. Since ancient days they have been used for its anti-inflammatory, carminative, antioxidant, anti-clotting, anti-microbial, anti...

S. Nivetha

Department of Chemistry, Arignar Anna College, Aralvoimozhy, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1342-51

1342-1351

699

284

3.

BREAKTHROUGHS IN TRANSDERMAL NANOSTRUCTURED LIPID CARRIER DRUG DELIVERY SYSTEMS

The important barrier in transdermal drug delivery (TDD) is the Stratum corneum (SC), the outermost layer of the skin, which acts as an excellent protective physiological barrier. To boost the penetration or permeation of drugs through SC, several tactics have been used including passive and active methods of permeation or both in combination. This unwraps the opportunity to broaden the range of d...

A. A. Shirkhedkar and P. S. Patil *

Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1352-66

1352-1366

535

306

4.

PRONIOSOMAL GEL: A NOVEL THERAPEUTIC TOPICAL / TRANSDERMAL DRUG DELIVERY SYSTEM

Today, Nanotechnology is widely used for leading new dosage forms. Vesicular drug delivery system is expanding as one of advanced nanotechnology. Delivery of drugs using colloidal particulate carriers and liquid crystalline compact niosomal hybrid such as niosome and proniosomes has peculiar advantages over conventional dosage forms. Proniosomes is a dry formulation using suitable carrier coated w...

S. S. Mahajan *, Y. R. Chaudhari, V. P. Patil and T. Y. Shaikh

Department of Pharmaceutics, Smt. S. S. Patil, College of Pharmacy, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1367-80

1367-1380

613

293

5.

REVIEW ON DERIVING A HYPOTHESIS FOR ACHIEVING SUPERIOR BIOAVAILABILITY OF CURCUMIN AS AN ANTITUMOR AGENT

Curcumin, chemically 1,7-bis (4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione derived from Curcuma longa L. is an active chemical constituent used medicinally worldwide from ancient times. Though Curcumin enjoying the reputation of many pharmacological actions, it has certain setbacks with poor bioavailability. The poor water solubility is said to be the reason for poor bioavailability, rathe...

R. Manju and K. Kannan *

Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1381-89

1381-1389

486

235

6.

A REVIEW ON TRADITIONAL MEDICINAL PLANTS USED AS ANTIDOTES IN THE TREATMENT OF SNAKE BITES IN INDIA

Envenoming and deaths resulting from snakebites are particularly important public health problems in the rural tropics. Snake envenomation is included since 2009 in the World Health Organization (WHO) list of Neglected Tropical Diseases, as this condition remains largely neglected by national and international health authorities. The only available specific treatment is antivenom therapy, which co...

N. K. Chilaka * and A. Ganguly

Department of Pharmacology, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1390-98

1390-1398

291

158

7.

THE STUDY ON OPTIMIZATION OF SOLID ORAL FLOATING TABLETS-A REVIEW

The motivation behind composing this review on floating drug delivery systems (FDDS) was to incorporate the ongoing research article with a unique spotlight on the key system of floatation to accomplish gastric maintenance. The ongoing advancements of FDDS, including the physiological and formulation factors influencing gastric maintenance, ways to deal with configuration single-unit, and numerous...

R. Pawar * and S. Jagdale

Department of Pharmaceutics, MAEER’s MIT College of Pharmacy, MIT Campus, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1399-11

1399-1411

250

136

8.

HEALTHCARE TRANSFORMATION THROUGH PERSONALIZED MEDICINE

Excessive heterogeneity in the phenotypic expression of drug treatment response and adverse drug reaction is resolute by a complex interaction of multiple hereditary variants and environmental aspects. The complex nature of treatment response greatly increases the need for personalized medicine. Drug metabolizing enzymes show monogenic genetic polymorphism and influence drug response. Cytochrome P...

U. Shakarwal, D. Srivastava and Z. Fatima *

Amity Institute of Pharmacy, Amity University, Lucknow Campus, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1412-20

1412-1420

323

135

9.

ONGOING ADVANCEMENT IN THE COMPREHENSION OF MITOCHONDRIAL PRO-GRESSION WITH AN EXCEPTIONAL SPOTLIGHT ON ITS RELATIONSHIP WITH CANCER AND POSSIBLE THERAPEUTIC STRATEGY

Cancer is one of the main reasons of death around the world and the quantity of new incidents keeps on rising. Despite ongoing advances in conclusion and remedial systems, many malignancy-related passes happen, demonstrating the requirement for better treatments and symptomatic methodologies. Mitochondrial morphology is dependent on continuous fusion and fission strategies that are essential for m...

D. Pal *, S. Pal and S. Mukherjee

Amity Institute of Pharmacy, Amity University, Lucknow Campus, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1421-32

1421-1432

241

144

Research Articles

 
Title
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10.

EFFECTS OF ORAL ZINC SUPPLEMENTATION IN EARLY NEONATAL LIVE ON DEVELOPMENT OF OBESITY AND METABOLIC SYNDROME IN ALBINO RATS

Background: Zinc (Zn) is the most common trace element in eukaryote cells and the second most abundant trace element in human tissues and secretions after iron. Zinc is required for normal growth and development from in uteri to puberty. There is a lack of evidence on Zn as a potential therapeutic agent to reduce weight and improve metabolic parameters in obese adults. Aim: to evaluate Zn suppleme...

A. E. N. El-Deen *, A. Taha, E. M. Fahmy and A. E. Mansour

Department of Physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.

DOI: 10.13040/IJPSR.0975-8232.12(3).1433-41

1433-1441

544

254

11.

DETERMINATION OF MACRO AND MICROELEMENTS CONTENTS IN GENTIANA MACROPHYLLA PALL. HERB

Macro and microelements are integrally linked to hormones, vitamins, amino acids, and enzymes in the human body. They affect the normal course of physiological processes. Some medicinal plants contain substantial contents of micro-and macro-elements, which makes it possible to use them purposefully for the prevention and treatment of various diseases. The target of the research was samples of G. m...

V. A. Tsukurova *, O. V. Evdokimova and V. I. Prokofieva

Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russian Federation, 119991.

DOI: 10.13040/IJPSR.0975-8232.12(3).1442-45

1442-1445

497

202

12.

PHYTOCHEMICAL ANALYSIS AND MYCOBACTERICIDAL STUDIES OF THE LEAVES OF C. MUCRONATUM SCHUMACH. & THONN.

Combretum mucronatum Schumach & Thonn is a scandent shrub whose leaves are widely used by Ghanaians and other West-African herbalists for the treatment of various infectious and non-infectious diseases. It is used to treat wounds, coughs, dysentery, worm infestation, neurological disorders and bacterial infections. Some coughs are as a result of mycobacterial infection. Despite the success gai...

E. Oppong Bekoe *, N. A. Mireku-Gyimah, V. E. Boamah and S. Martinson

Department of Pharmacognosy & Herbal Medicine, School of Pharmacy, University of Ghana, Ghana.

DOI: 10.13040/IJPSR.0975-8232.12(3).1446-52

1446-1452

486

266

13.

DESIGN, SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NEWER POTENT APOLIPOPROTEIN E4 INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE

A major genetic suspect for Alzheimer's disease is the pathological conformation assumed by Apolipoprotein E4(Apo E4) through intramolecular interaction. The aim of the current study is to synthesize newer potent Apo E4 inhibitors. In the present study, with specific pharmacophoric features of three Hydrogen bond donors and three hydrophobic spheres, a large library of ligands was constructed for ...

R. Priyadarsini * and P. L. Kumar

Department of Pharmaceutical Chemistry, Madras Medical College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1453-64

1453-1464

519

239

14.

FRESH JUICE OF DRYNARIA QUERCIFOLIA RHIZOME FOR THE MANAGEMENT OF ARTHRITIS

Drynaria quercifolia rhizome (DQR) ethnomedicinal information shows the traditional usage of this rhizome for the treatment of body and joint pain, diarrhoea, typhoid, cholera, and skin diseases. The fresh juice of rhizome is still being consumed as an energy drink by tribes and localities of Tamil Nadu and Kerala. However, no investigations have been carried out to claim the anti-arthritic activi...

U. M. Dhanalekshmi, B. Ramya, T. Gowri and R. Srinivasan *

Organic and Bio Organic Chemistry Division, CLRI, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1465-73

1465-1473

540

238

15.

IN-SILICO ANALYSIS OF MTA1 AS DRUG TARGET AGAINST NATURAL ANTIOXIDANTS

The protein MTA1 with histone deacetylase activity is a member of the nucleosome remodeling complex encoded by the mta1 gene is frequently overexpressed in biologically aggressive epithelial neoplasms. MTA1 is a nuclear co-regulatory molecule that is highly expressed in many cancers and correlates with tumor metastasis and progression. MTA1 alters signaling events in the tumor micro-environment. M...

R. Pinnamaneni *, P. Gandham, J. Tatineni, R. Vemparala, S. Shaik and S. Kamma

Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Greenfields, Vaddeswaram, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1474-81

1474-1481

258

151

16.

FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF BACLOFEN

The present study was aimed to formulate and evaluate floating microspheres of Baclofen. The research work's objective was to retain Baclofen in the stomach for a prolonged period of time, which has absorption window in the upper gastrointestinal tract. The microspheres were prepared by solvent evaporation technique. A 32 full factorial was applied to investigate the combined effect of the two ind...

H. Prajapati *, K. Patel and A. K. Gupta

Chameli Devi Institute of Pharmacy, Village Umrikheda, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1482-94

1482-1494

369

173

17.

ANTITUMORIGENIC EFFECT OF VARIOUS PARTS OF FICUS RACEMOSA IN DALTON LYMPHOMA ASCITES TUMOR INDUCED SWISS ALBINO MICE

Medicinal plants play an important role in the development of potent therapeutic agents. In recent years there has been an increased interest in using of herbal medicines. To assess the antioxidative and antitumorigenic efficacy of methanolic extract of bark, fruits, and leaves of Ficus racemosa in Dalton Lymphoma Ascites tumors transplanted Swiss albino mice. The results showed that the cytotoxic...

A. Poongothai * and S. Annapoorani

Department of Biochemistry, Sacred Heart College (Autonomous), Tirupattur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1495-03

1495-1503

220

128

18.

A COMPARATIVE INVESTIGATION OF METHANOL AND SILVER NANOPARTICLES EXTRACTION FROM CORIANDRUM SATIVUM SEEDS FOR ANTIDIABETIC POTENTIALITY – IN-VITRO

Botanical name of coriander is Coriandrum sativum Linn. Coriandrum sativum belongs to the family Umbelliferae which is a highly reputed ayurvedic medicinal tree commonly known as Dhania. Essential oils, flavonoids, fatty acids, and sterols have been isolated from different parts of C. sativum so far. The phytochemical analysis of both methanol and AgNP’s extract was evaluated. Results revealed t...

K. S. Divya *, D. M. Nijagal and J. B. Chauhan

Department of Studies in Microbiology, Pooja Bhagavat Memorial Mahajana PG Centre, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1504-14

1504-1514

242

158

19.

IDENTIFICATION OF POTENTIAL INHIBITOR AGAINST EXFOLIATIVE TOXIN A ASSOCIATED WITH STAPHYLOCOCCUS AUREUS INFECTION – A MOLECULAR DOCKING APPROACH

Staphylococcus aureus is a frequent colonizer of the human body as well as a serious human pathogen. It can cope with stress factors and acquire resistance to antibiotics, thus rendering treatment difficult. Discovering new treatments for this disease is urgently required, especially in view of the emergence of multiple drug resistant organisms and to reduce the total duration of current treatment...

P. Vijayalakshma, J. Selvarajb and M. Rajalakshmi *

Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Tiruchirapalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1515-20

1515-1520

231

138

20.

IN-SILICO STUDY OF TOXICITY MECHANISMS FOR METABOLITES OF PHYTO-COMPOUNDS FROM MUSA SP. COMPARED TO SYNTHETIC MEDICINE RANITIDINE

An in-silico attempt to predict rat oral acute toxicity, hepatotoxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor (NR) signaling, and stress response (SR) pathways of metabolites of synthetic medicine Ranitidine and flavonoids of Musa sp. The metabolites of common flavonoids and synthetic medicine were taken from literature, and the prediction was done by using ProTox-II webser...

D. R. Choudhury *, S. Chowdhury, P. Talukdar and S. N. Talapatra

Department of Basic Science and Humanities, Institute of Engineering & Management, Bidhannagar, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1521-28

1521-1528

326

124

21.

IDENTIFICATION AND DOCUMENTATION OF EDIBLE INSECTS OF VESPA AFFINIS IN NAGALAND BY USING DNA BARCODE TECHNIQUES

DNA bar-coding is an ordered strategy that utilizes a little genetic marker in insect DNA to distinguish animal categories, as well as unidentified species. The present investigation manages the utilization of COI gene sequences in the distinguishing proof and documentation of edible insects in Nagaland. More than 2000 types of edible insects are recorded in more than 300 ethnic groups all around ...

L. Tzudir and M. Markandan *

Department of Zoology, St. Joseph University, Dimapur, Nagaland, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1529-32

1529-1532

249

143

22.

REINVESTIGATION OF SYNTHESIS OF ENOXAPARIN UNDER PTC CONDITIONS

Heparin is a mixture of glycosaminoglycan (GAG) chains originating from the porcine intestinal mucosa. It is used therapeutically as an anticoagulant for the treatment and prevention of thrombosis. Glyco-saminoglycans such as heparin (H) and heparan sulfate (HS) are considered attractive therapeutic agents because they modulate many biological processes and have been implicated in numerous patholo...

P. Venkatanarayana, B. Prasanna * and N. Seelama

Department of Chemistry, Chaitanya (Deemed to be University), Kishanpura, Hanamkonda, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1533-36

1533-1536

273

121

23.

ANTIMYCOBACTERIAL SCREENING OF SELECTED MEDICINAL PLANTS USING MTT AND THE MICROPLATE RESAZURIN ASSAY

Tuberculosis holds one of the top places on the list of the main cause of death in India. At times, the patients fail to respond to treatment with anti-Tb drugs, drug resistance being one of the reasons. The increasing incidence of MDR and XDR-TB highlights the urgent need to search for newer anti-Tb drugs. For last many years, plants have beneficial activity in a different types of diseases produ...

K. D. Jethva *, D. R. Bhatt and M. N. Zaveri

K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1537-45

1537-1545

227

129

24.

GASTRPROTECTIVE & ANTI-ULCER ACTIVITY OF SACCHARUM OFFICINARUM FRESH JUICE IN CHEMICAL INDUCED ULCER IN ALBINO RATS

Objects: In the present study the anti-ulcer activity of Saccharum officinarum fresh juice was investigated in the chemical-induced ulcer. The efficacy of the plant based juice was compared with standard reference anti-ulcer drug Ranitidine. Methods: The fresh juice collected from the plant of S. officinarum. Firstly, washes the sugarcanes well and peel the outer layer of the cane with a big knife...

R. Singh * and R. Shukla

School of Pharmaceutical Science, Shri Venkateshwara University, Gajraula, Amroha, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1546-52

1546-1552

244

120

25.

FORMULATION AND CHARACTERIZATION OF ECONAZOLE NITRATE LOADED TRANSFERSOMAL GEL FOR ANTIFUNGAL ACTIVITY

The aim of the present work is to formulate and characterize Econazole nitrate (EN) loaded transfersomal gel for antifungal activity. EN is a broad-spectrum imidazole antifungal agent that belongs to BCS Class II. Due to poor solubility, EN is incompletely absorbed after oral administration and bioavailability vary among individuals. Topical treatment of fungal infections is usually preferred, but...

P. M. Chaudhari * and S. D. Rasal

Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1553-65

1553-1565

279

167

26.

EFFECT OF BIOCOMPOSTED VEGETABLE AND GROUNDNUT SHELL WASTE ON THE GROWTH IMPACT OF PIGEON PEA (CAJANUS CAJAN (L.) MILL SP.)

Department of Botany, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, conducted a pot culture experiment for analyzing the effect of bio-composted groundnut shell and vegetable waste on the growth impact of Pigeon pea (Cajanus cajan (L.) Mill sp. Organic wastes and by-products are renewable forms of resources generated all over the world. The prese...

R. Rajashri, A. Vijayalakshmi *, M. Silpa, P. Raihing and K. Gnanamani

Department of Botany, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1566-72

1566-1572

278

129

27.

A STUDY ON TRADITIONAL DICOTS AS COMBAT TO WOUND MICROBIAL CLUSTERS

Antibiotic resistance emergence, as well as the Darwinism of up to the minute strains of ailment generating agents, is of grave concern to the global health community. Sustainable therapeutics of an ailment entails the amalgamation of contemporary pharmaceuticals or some potential prospective of novel drugs. Customarily employed medicative plants of Gopalganj community could be an enticing of drug...

A. Kumar and S. Ahmad *

Department of Botany, Gopeshwar College Hathwa, Gopalganj, Bihar, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1573-81

1573-1581

234

123

28.

DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FENTANYL CITRATE BOTH IN BULK AND MICRO-EMULSION FORMULATION

Objective: Development of simple, rapid, and accurate UV spectrophotometric method for the estimation of Fentanyl citrate (FC) in a bulk and pharmaceutical dosage form. The proposed method was validated according to the guidelines of the International Conference on Harmonization and the Association of Official Analytical Chemists International. Methods: The method was based on the measurement of a...

D. Mundhey *, N. Sapkal and A. Daud

Centre for Advanced Research & Innovation (CARIn), Zim Laboratories Ltd. B-21/22, Kalmeshwar, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1582-87

1582-1587

231

138

29.

ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF SECONDARY METABOLITE PRODUCED BY ENDOPHYTIC FUNGI ISOLATED FROM LANNEA COROMANDELICA (HOUTT.) MERR

Lannea coromandelica (Houtt.) Merr. which is known as Kayu Jawa in Bugis community, Indonesia has been widely used empirically for the treatment of wounds. Ethanol extract from its stem bark is known to have antibacterial, anti-inflammation, and antioxidant activity. The purpose of this study were to isolate, characterize, and determine the antioxidant and antimicrobial activity of the endophytic ...

P. Amelia *, P. A. K. Ivada, N. Fitriana, I. Komala, S. Bahri and M. Hanafi

Department of Pharmacy, Faculty of Health Sciences, Universitas Islam Negeri (UIN) Syarif Hidayatullah Jakarta, Tangerang, Banten, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.12(3).1588-92

1588-1592

350

198

30.

GC-MS AND FT-IR ANALYSIS OF METHANOLIC EXTRACT OF A MARINE CNIDARIAN ZOANTHUS SANSIBARICUS IN SEARCH OF BIOACTIVE COMPOUNDS

Present study was aimed to search bioactive functional groups and compounds in the whole animal extract of a marine cnidarians Zoanthus sansibaricus by FT-IR and GC-MS. The methanol extract was used to detect bioactive functional groups and compounds. GC-MS of the animal extract was done, and FTIR analysis was thereafter used to identify the functional groups. The bioactive components were identif...

J. Raja, S. Pathak and R. Kundu *

Department of Biosciences, Saurashtra University, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1593-98

1593-1598

230

135

31.

A NEW WAY OF METHOD ESTABLISH AND VALIDATED OF RELATED SUBSTANCE OF GLASDEGIB BY RP-HPLC AND ITS FORCED DEGRADATION STUDY

A novel, simple, and accurate, high-performance liquid chromatographic method has been a developed with quantitative analysis of Glasdegib using Waters X-Bridge C18 150 × 4.6mm, 3.5µ column with a flow rate of 1ml/min. The buffer containing 0.1% OPA and the mixture of two components like Buffer and Acetonitrile in the ratio of 50: 50 is used as mobile phase. The detection was carried out at 250n...

P. Satyanarayana, S. Bajivali, M. Usharani and S. Mohan *

Department of Chemistry, Bapatla Engineering College, Bapatla, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1599-07

1599-1607

236

152

32.

MOSQUITO LARVICIDAL ACTIVITY OF HYPTIS SUAVEOLENS (L) POIT EXTRACTS PURIFIED FRACTION

Bio-pesticides are playing a very important role in controlling mosquitoes and their larvae. In the present scenario, chemical pesticides are causing several side effects on non-target organisms, particularly in men. Moreover, mosquitoes and their larvae become resistant to chemical pesticides; therefore, chemical pesticides are not much more effective. The conventional use of temephos and pyrethr...

M. Singh, R. Namdeo and K. K. Soni *

Department of Biosciences, Barkatullah University, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1608-14

1608-1614

251

136

33.

ACCELERATED STABILITY STUDY OF ARSENAZO III USED FOR DETECTION OF CALCIUM FROM BIOLOGICAL SYSTEM THROUGH UV-SPECTROPHOTOMETER, BIOCHEMISTRY ANALYZER, PH METER, HPLC AND HPTLC

Objective: Stability of In-vitro Diagnostics (IVDs) reagents was performed to check its quality standards, performance, and linearity. IVDs like Calcium reagent containing Arsenazo III were studied by Accelerated stability studies by considering temperature, pH, and light parameters. Materials and Methods: Stability data were obtained by using different instruments like UV spectrophotometer, Bioch...

J. R. Kamble, A. S. Sherikar ⃰ and J. I. Disouza

Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar, Panhala, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1615-23

1615-1623

233

136

34.

PHARMACOGNOSTIC AND PHYTOCHEMICAL STUDIES ON A RELIGIOUS HERB OCIMUM TENUIFLORUM L.

"The Queen of Herbs" – Tulsi (Ocimum tenuiflorum), is the most sacred herb of India, also known as the holy Basil, is ubiquitous in Hindu tradition. Tulsi has been revered in India for over five thousand years as a healing balm for body, mind, and spirit. It is known to bestow an amazing number of health benefits. Modern scientific research offers impressive evidence that Tulsi reduces stress, e...

A. Ashwini, K. C. Sagar and V. Danapur *

Department of Phytomedicine, Vriksha Vijnan Private Limited, Chikkalsandra, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1624-29

1624-1629

327

161

35.

EVALUATING THE PARAMETERS FOR SELECTING THE BEST METHOD FOR THE PRE-PARATION OF NANOCRYSTALS BY USING FUZZY ANALYTIC HIERARCHY PROCESS

The aim of this paper is to select the best method for the preparation of nanocrystals by using the fuzzy analytic hierarchy process (Fuzzy-AHP) methodology. The commonly used methods for the preparation of nanocrystals are Hydrosol, sonoprecipitation, spray freezing into liquid, and Nanomorph®. There are several parameters to take into consideration for the selection of the best method like oper...

V. Kyavars

Mother Theresa Institute of Pharmaceutical Education and Research, Kurnool, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1630-43

1630-1643

200

131

36.

STUDIES ON GC-MS PROFILING OF SOME SEAWEEDS OF MAHIM BEACH DIST. PALGHAR, MAHARASHTRA USING VARIOUS SOLVENTS

Objective: To investigate the bioactive constituents of Ulva lactuca, Sargassum prismaticum, and Sarconema filiforme using gas chromatography-mass spectrometry (GC-MS) analysis. Methods: 10 gm sample of each seaweed was successfully extracted with HPLC grade methanol and pet. ether with continuous shaking in a dark room for 36 h. The concentrated extracts were subjected to GC MS analysis. Results:...

V. Chabake, S. Chaubal * and T. Patil

Department of Botany, Mah. Govt’s Elphinstone College Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1644-50

1644-1650

212

154

37.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METOPROLOL, TELMISARTAN AND CLINIDIPINE IN TABLET

RP-HPLC method has been developed for separation and quantification of Metoprolol succinate, Telmisartan, and Clinidipine using Phenomenex Luna C18 column (150 mm × 4.6 mm, 5 µm) as a stationary phase with security guard cartridge C18 (4 × 3 mm) and acetonitrile: methanol: phosphate buffer pH 7.5 (45:30:25) as a mobile phase by isocratic elution at the flow rate of 1.0 ml/min. The detection was...

M. S. Kalshetti * and S. S. Kankure

Department of Pharmaceutical Quality Assurance, D. S. T. S. Mandal’s College of Pharmacy, Solapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1651-57

1651-1657

263

160

38.

ANTIMUTAGENIC ACTIVITY OF POMEGRANATE EXTRACT AND 2 – METHOXY-ESTRADIOL IN COMBINATION ON SWISS ALBINO MOUSE – MUS MUSCULAS

Pomegranate extracts (PGEs) exhibit antioxidative, antiproliferative, and antineoplastic activities. 2-Methoxyestradiol (2-ME), the end metabolite of 17β estradiol (E2), an antiangiogenic agent, inhibits tumor growth. Our earlier investigations demonstrated that aqueous PG extract (PGE) in combination with 2-ME showed antineoplastic effect on Sarcoma-180 tumor cells. The present paper has been or...

A. Banerjee and S. N. Banerjee *

Department of Zoology, Rammohan College, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1658-70

1658-1670

214

129

39.

PHYSICOCHEMICAL AND PHYTOCHEMICAL ANALYSIS OF METHANOLIC EXTRACT OF LEAVES AND FRUITS OF FLACOURTIA JANGOMAS (LOUR.) RAEUSCH

Plants have been used extensively as medicine for the treatment of various ailments for centuries. The present study was conducted to analyze physicochemical and phytochemical parameters of leaves and fruit of Flacourtia jangomas (Lour.) Raeusch  Physicochemical profile showed the high total ash, water-soluble ash, and acid-soluble ash content in F. jangomas leaf when compared to the fruit. The w...

A. Pai and K. C. Shenoy *

Department of Biosciences, Mangalore University, Mangalagangothri, Dakshina Kannada, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1671-78

1671-1678

242

141

40.

GC-MS AND FT-IR ANALYSIS OF METHANOL FRUIT EXTRACT OF FICUS RACEMOSA AND FICUS AURICULATA

The fruits of the plant Ficus racemosa and Ficus auriculata are consumed as a wild edible fruit and have also been used extensively in traditional medicine to treat various illnesses ranging from diarrhea, dysentery, jaundice to diabetes, piles, asthma, and urinary diseases. Gas Chromatography-Mass Spectro-metry (GC-MS) analysis of methanol extract of the fruits was carried out to identify the pos...

M. Paul * and N. Devi

Department of Botany, Gauhati University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1679-84

1679-1684

258

154

41.

PHYTOPHARMACOGNOSTICAL STUDY OF SOME SELECTED ANTITUBERCULOSIS PLANTS AND STUDY OF ITS CYTOTOXICITY SCREENING USING VERO CELL LINE

Tuberculosis (TB) is one of the leading infectious diseases and health burdens in the world. One-third of the world’s population, including 40% from India, is estimated to be infected with tuberculosis. Current studies have indicated the urgent need for the development of new, safe, and efficacious drugs to help reduce the global burden of tuberculosis. Novel antimycobacterial scaffolds from na...

K. Jethva *, D. Bhatt and M. Zaveri

K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1685-98

1685-1698

210

120

42.

DOCKING – BASED VIRTUAL SCREENING OF LIPINSKI COMPLIANT 2 -ARYLQUINA-ZOLIN – 4 – ONE DERIVATIVES: A MOMENTUM TO THE DISCOVERY OF NOVEL EGFR INHIBITORS

The epidermal growth factor receptor (EGFR), which is a potential anticancer drug target, is over-expressed in non-small-cell lung cancer (NSCLC). The present study is an attempt to explore the human EGFR (protein data bank code: 1M17) inhibition potential of Lipinski compliant compounds possessing 2-arylquinazoli-4-one scaffold with chalcone structural motif; by docking analysis, using Auto Dock ...

P. K. Arora * , S. Kumar and S. K. Bansal

Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1699-12

1699-1712

302

128

43.

EFFECT OF SHORT TERM DIETARY ZINC DEFICIENCY AND ZINC SUPPLEMENTATION ON WISTAR RAT ERYTHROCYTE: BIOCHEMICAL STUDIES

Deficiency of zinc has been reported in developed and developing countries due to low zinc intake, which also accounts for crops grown in low zinc areas. 2 billion people still remain at risk of zinc deficiency affecting all age groups in spite of proven benefits of adequate zinc nutrition. The study evaluates the effect of dietary zinc deficiency on male Wistar rat erythrocytes for 2-, 4- and 6 w...

N. Nair *, P. Sharma, S. Bedwal, S. Singh, D. Kumari, A. Saini and R. S. Bedwal

Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1713-22

1713-1722

219

119

44.

SYNTHESIS OF 2-(2-(2-(BIS (2-CHLOROETHYL) AMINO) ETHOXY) BENZYLIDENE) BENZOFURAN – 3(2H) – ONE DERIVATIVES ON BASIS OF BENZALDEHYDES AND ACETOPHENONES FOR ITS CYTOTOXIC ACTIVITY

Benzofuranones and nitrogen mustards have been reported as highly potential alkylating agents; with this evidence, the synthesis of some benzofuranones fused with nitrogen mustards was planned and was subjected to in-vitro cytotoxic studies. Substituted benzofuranones were synthesized by condensation of 2-hydroxy benzaldehydes and substituted 2-hydroxy acetophenones and further fused with nitrogen...

A. R. Mahesh * and V. Murugan

Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1723-28

1723-1728

237

144

45.

ISOLATION OF AROMATIC AND MEDICINAL COMPOUNDS FROM ISODON NILGHERRICUS (BENTH.) H. HARA – AN ECONOMIC ASPECT

The secondary metabolites being defensive function in plants, the men also thought of using same to defend the chronic diseases by crud drugs or with some organic aromatic molecules. The phenyl groups and other functional groups are bonded together, forming aromatic organic molecules. These molecules are used in perfumes and medicines. The qualitative and quantitative aromatic and medicinal compou...

N. H. Godse *, S. P. Jagdale and B. M. Gaykar

Department of Botany, Ahmednagar College, Ahmednagar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1729-34

1729-1734

206

126

46.

CHEMICAL COMPOSITION, ANTIGENOTOXIC, ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITIES OF N-BUTANOL FRACTION FROM PTERIS VITTATA L.

Pteris vittata L., a fern species in the Pteridoideae subfamily of Pteridaceae, is known to possess various medicinal properties. P. vittata is used as a folk medicine in the Eastern Ghats of Tamil Nadu, Western Ghats, and Vindhyan region of Madhya Pradesh, India. The present study was undertaken to evaluate antigenotoxic, antioxidant, and antiproliferative potential of P. vittata L. HPLC analysis...

P. Kaur, S. Kaur and S. Kaur *

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1735-45

1735-1745

238

130

47.

NEPHROPROTECTIVE ACTIVITY OF CHLOROFORM EXTRACT OF ABRUS PRECATORIUS IN RATS

This study seeks to evaluate the nephroprotective activity of chloroform extract of Abrus precatorius against gentamycin-induced nephrotoxicity in rats. Albino rats of Wistar strain of both sexes were used for the study and grouped into five, containing 6 animals. The study was performed for 14 days. For induction of nephrotoxicity, gentamycin and paracetamol were used, and the plant extract was g...

K. N. Kumari * and S. S. Basha

Department of Pharmacology, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1746-51

1746-1751

216

135

48.

PHYTOCHEMICAL INVESTIGATION, ISOLATION AND CHARACTERIZATION OF BETULIN FROM LEAF OF GYMNOSPORIA MONTANA

Ethnomedicinal plant-like Gymnosporia montana belonging to the family Celastraceae is commonly known as Vikalo in Gujarat. Ethanomedicinally, fresh leaves of Vikalo are chewed in trible regions of Gujarat to cure jaundice. Phytochemical screening of the plant showed the presence of phytoconstituents like phenol, flavonoids, alkaloids, triterpenoids, and saponin. The present study was undertaken fo...

D. Bhavita *, B. Lakshmi and M. Zaveri

K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1752-56

1752-1756

227

121

49.

MICROSCOPIC CHARACTERISTICS AND LEAF CONSTANT NUMBERS OF SELECTED DERRIS SPECIES IN THAILAND

Medicinal plant identification is necessary for ensuring their efficacy and safety in the quality control of herbal products. The genus Derris belongs to the Leguminosae family. This study aimed to investigate the microscopic characteristics of selected Derris species in Thailand. Eight Derris species (D. amoena, D. elliptica, D. indica, D. malaccensis, D. recticulata, D. scandens, D. solorioides,...

K. Phairoh, P. Hongsing, C. Palanuvej and N. Ruangrungsi *

Public Health Sciences Program, College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand.

DOI: 10.13040/IJPSR.0975-8232.12(3).1757-61

1757-1761

465

127

50.

NOVEL METHOD FOR SEPARATION AND QUANTIFICATION OF POTENTIAL IMPURITIES BY RP-HPLC FROM KSM STAGE TO API STAGE OF DABIGATRAN MESYLATE

Dabigatran mesylate is a novel oral anticoagulant that works by blocking the clotting protein thrombin. The present work describes the separation and quantification of potential impurities in a single HPLC method, which are generated from raw materials to API synthesis. This method is capable of separating and quantifying the fourteen impurities, produced from the intermediate stages to final drug...

T. N. Jhansi *, R. Nagaraju, D. J. D. Kumar and G. N. Rao

Department of Analytical Research and Development, Dr. Reddy’s Laboratories Ltd., Srikakulam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1762-79

1762-1779

272

134

51.

EVALUATION OF PROTECTIVE EFFICACY OF PUNICA GRANATUM ON SHORT TERM Β-CYFLUTHRIN TOXICITY ON REPRODUCTIVE TISSUE OF MALE MICE

Pyrethroids are among the most extensively used insecticide. The widespread use of these synthetic pesticides has stimulated research into the possible existence of adverse effects related to reproductive activity. The present study was, therefore, undertaken to assess the effects of β- Cyfluthrin, a type II synthetic pyrethroid on testes, the main organ of male reproduction. Animals were divided...

S. Pal, H. N. Highland and K. R. Desai *

Department of Zoology, BMT & HG, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1780-88

1780-1788

424

130

52.

FORMULATION AND DEVELOPMENT OF QUERCETIN AND MONOAMMONIUM GLYCYRRHIZINATE LOADED GEL FOR THE TREATMENT OF MOUTH ULCER DISEASE

Diagnosis of oral ulcerative lesions might be quite challenging. Oral ulcerative lesions were categorized into three major groups as acute, chronic, and recurrent ulcers. Helicobacter pylori (H. pylori) have been found in the oral cavity and stomach, and its infection is one of the most frequent worldwide. There is a close relation between H. pylori infection in the oral cavity and the stomach. H....

S. A. K. Shivaji * and R. V. Vaibhav

Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1789-98

1789-1798

341

139

53.

ISOLATION, IDENTIFICATION OF NON-POLAR TERPENES AND TOTAL ANTIOXIDANT ACTIVITY FROM CHLOROFORM EXTRACT OF BOUGAINVILLEA GLABRA LEAVES

This study reports the isolation and antioxidant activity of non-polar terpenes extracted from the leaves of Bougainvillea glabra choicy. To characterize the phytochemical constituents of Bougainvillea glabra leaves using the GC-MS method. The 95% ethanol extract was filtered, distilled, and concentrated to obtain the solid greenish residue. The residue was further fractioned by n-hexane, chlorofo...

J. M. J. Rani

Department of Chemistry, Annai Vailankanni Arts and Science College, Bishop Sundaram Campus, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1799-04

1799-1804

281

143

54.

ANTIOXIDANT ACTIVITY OF CASSIA AURICULATA AND CASSIA FISTULA EXTRACT ALONG WITH WOUND HEALING ACTIVITY OF ITS POLYHERBAL FORMULATION

Due to emergent concerns about unhealthy consequences of chemicals in the health industry, the interest towards natural and herbal substances has been growing every day. In this study, the antioxidant effect of Cassia fistula [CFF] and Cassia auriculata [CAF] extract was evaluated. Also discover wound healing activity of polyherbal formulation (CFF and CAF). The antioxidant activity of the extract...

S. M. Kewatkar *, V. V. Paithankar, S. S. Deshpande, S. P. Jain and D. H. Nagore

Rajarshi Shahu College of Pharmacy, Buldana, Maharastra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1805-10

1805-1810

234

119

55.

IN-VITRO EVALUATION OF ANTIULCER ACTIVITY OF AQUEOUS EXTRACT OF MALVASTRUM TRICUSPIDATUM

There are several factors that may induce ulcers in human beings such as stress, chronic use of anti-inflammatory drugs, etc. Though in most cases, the etiology of ulcer is unknown, it has generally accepted that it is the result of an imbalance between aggressive factors and maintenance of the mucosal integrity through the endogenous defense mechanism. Thus, the search for a safe anti-ulcer drug ...

P. Pandian

Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1811-15

1811-1815

295

136

56.

FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF HYDROGEL BASED CONTROLLED RELEASE MATRIX TABLET OF PROPRANOLOL HYDROCHLORIDE

Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCL is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study hydrogel matrix...

A. Talukdar *, H. B. Bayan and M. Islam

NETES Institute of Pharmaceutical Science, NEMCARE Group of Institutions, Mirza, Assam India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1816-22

1816-1822

219

135

57.

MOLECULAR DOCKING STUDY ON SARS-COV-2 PROTEASE INHIBITION BY EXPLORING BIOACTIVE COMPOUNDS FROM DIFFERENT PLANTS

The novel human coronavirus which has been designated as SARS-CoV2 initially appeared in December 2019 in Wuhan, China causing a respiratory illness called COVID-19. The SARS-CoV2 is a β coronavirus belonging to the family Coronaviridae is a global public health emergency infecting many people all around the world, especially in India with more than 10.8 million cases. Henceforth there is an urge...

F. B. Sharon * and J. S. Kris

Department of Food Science and Nutrition, Sarah Tucker College, Tirunelveli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1823-33

1823-1833

440

171

58.

DISSOLUTION METHOD DEVELOPMENT AND VALIDATION FOR DERACOXIB CHEWABLE TABLET USING UV SPECTROPHOTOMETRIC METHOD

Deracoxib is a coxib class of Non Steroidal Anti-Inflammatory Drug (NSAID). Like other NSAIDs, its effects are caused by inhibition of Cyclooxygenase (COX) enzymes.  Deracoxib causes greater inhibition of COX-2 than of COX-1. The aim of this proposed method was to develop and validate the UV spectrophotometric method for the routine quality control check of API containing 25 mg Deracoxib intablet...

M. Dhoru *, Y. Chandekar and K. Detholia

Department of Quality Assurance, Smt. S. M. Shah Pharmacy College, Mahemdavad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1834-38

1834-1838

292

146

59.

SYNTHESIS, PHARMACOKINETIC AND PHARMACOLOGY OF MUTUAL PRODRUGS OF FENBUFEN AND PROPYPHENAZONE

Mutual prodrugs of fenbufen and propyphenazone were synthesized with the aim of getting better therapeutic index through avoidance of gastrointestinal problems and to check the efficiency of release of parent drug in the presence of spacer. These mutual pro-drugs were synthesized by direct esterification and by using glycine as a spacer. The title compounds (FP1 & FP2) were characterized by sp...

Himanshu, Sucheta *, Ruchita, M. Paliwal, Monika and S. Jain

School of Medical and Allied Sciences, K. R. Mangalam University, Gurugram, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1839-48

1839-1848

256

127

60.

FORMULATION DEVELOPMENT AND EVALUATION OF ATORVASTATIN CALCIUM LIQUISOLID TABLETS

The solubility and dissolution properties of any drug are vital determinants of its oral bioavailability. The aim of this study was to increase the dissolution rate of poorly soluble drug Atorvastatin calcium by delivering the drug as a liquisolid compact, prepared by using PEG as a solvent, Avicel PH 102 as carrier, silica, and lactose are used as coating materials. Sodium starch glycolate was us...

P. R. Patil *, P. R. Mahaparale and K. U. Shaikh

Department of Pharmacy, Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1849-59

1849-1859

272

140

61.

FORMULATION AND STATISTICAL OPTIMIZATION OF S-SMEDDS OF NICARDIPINE HYDROCHLORIDE BY USING BBD AND PCA DESIGN

The study purpose is to further enhance the rate of dissolution for poorly water-soluble drug Nicardipine Hydrochloride by dissolving NH in surfactant, Co-surfactant, and oil; phase diagram was plotted by using oil (Capmul MM C8 EP), surfactant (Labrasol), and co-surfactant (PEG 400) through which a region called microemulsifying region was obtain. The batches were optimized by holding a 3-factor ...

R. L. Dumpala * and A. Khodakiya

Department of Pharmaceutical Science, Research, Development & Innovation Centre (RDIC), C.U. Shah University, Wadhwan, Surendranagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1860-74

1860-1874

265

138

62.

ISOLATION AND STRUCTURAL ELUCIDATION OF IMPURITY IN NEBIVOLOL

In the synthesis of Nebivolol [a mixture of (1RS, 1' RS)-1,1'-{(2RS, 2' SR)-bis(6-fluoro 3, 4-dihydro-2H-1-benzopyran-2-yl)} -2,2'-iminodiethanol] having four chiral centers, one crucial isomeric impurity at 0.88 RRT was observed in HPLC related substance analysis in gradient HPLC method. This impurity was isolated from synthesized crude impurity substance by preparative HPLC with chiral normal ph...

K. Gadani, M. Mehta and N. Shorgar *

Department of Chemistry, PAHER University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1875-80

1875-1880

302

141

63.

GREEN SYNTHESIS OF SILVER NANOPARTICLE BY USING TINOSPORA CORDIFOLIA LEAF EXTRACT AND ITS ANTIMICROBIAL PROPERTY

Tinospora cordifolia is one of the best medicinal plants holds most prominent place in Ayurveda Rasayana herbs and it also known as “rejuvenate herbs” because of its medicinal properties. It has been found to exhibit anti-microbial properties, its anti-microbial feature found in root, stem, and leaf extracts on pathogenic micro-organisms. Green synthesis of AgNPs can potentially eliminate chem...

B. Prajwala, T. S. Gopenath, N. Prasad, S. Raviraja and M. K. Basalingappa *

Division of Molecular Biology Faculty of Life Sciences, JSS AHER, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1881-86

1881-1886

380

180

64.

BIOGAS PRODUCTION FROM CO-DIGESTION OF TEXTILE DYE AND RICE HUSK USING AGARICUS HETEROCYSTIS

The waste generated from the textile industry is used for the production of biogas under the anaerobic digestion method. This study investigated the effect of various parameters such as Temperature 27 °C – 31 °C, pH 8-10, Inoculum concentration 35-55 ml on the textile dye with rice husk by the Agaricus heterocystis for biogas production using Response surface methodology. Maximum biogas yield ...

P. Sakthiselvan * and M. A. Aravindhan

Department of Bioengineering, Vels Institute of Science Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1887-94

1887-1894

216

121

65.

OCCURRENCE OF ASPERGILLUS FLAVUS AND AFLATOXIN B1 IN PADDY AND IT MILLING FRACTIONS WITH REFERENCE TO NORMAL AND CONTROLLED MILLING ENVIRONMENT

The contamination of Rice and its by-products with storage fungi, especially toxigenic Aspergillus flavus and Aflatoxin B1 leads to potential health hazard to human and domestic animals. Therefore, the present investigation was focussed on the comparative analysis of the fungal contamination with A. flavus and Aflatoxin B1 in Raw and Parboiled paddy and its milling fractions like Husk, Brow Rice, ...

K. Vadamalaikrishnan and P. Jayaraman *

PG and Research Department of Botany, Government Arts College for Men (Autonomous), Nandanam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1895-02

1895-1902

196

123

66.

ANTI-BACTERIAL EFFICACY OF PHYTOGENIC SILVER AND GOLD NANOPARTICLES OF LANTANA CAMARA. LINN AGAINST ENTERIC PATHOGENS

Antibiotic resistance could be a natural phenomenon that occurs when an antibiotic loses its ability to control or kill the bacterial growth; in other words, the bacteria become "resistant" and still continue to multiply in the presence of therapeutic levels of an antibiotic. Nano-technology is one of the foremost active areas in modern science. Nano particles exhibit a completely new or improved ...

M. Gowdhami, R. Balagurunathan and P. M. Ayyasamy *

Department of Microbiology, School of Bio Sciences, Periyar University, Salem, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1903-14

1903-1914

207

118

67.

ADVERSE DRUG REACTION MONITORING AMONGST DIABETIC PATIENTS OF TERTIARY CARE CENTRE OF NORTHERN INDIA RELATED TO ANTI-DIABETIC DRUGS

Diabetes mellitus caused by inherited and/or acquired deficiency in insulin production or by the development of insulin resistance. This is chronic as well as moderately increasing day by day in developing countries as well as globally and has reached about to the epidemic ratio, and now it is a matter of worry for the populations. This deficiency results in increased blood glucose concentrations,...

S. Mishra *, N. Nigam, S. S. Ahmad, P. Shankar, S. Kumar, V. Kumar and S. Gupta

Department of Pharmacology, Rama Medical College Hospital & Research Centre, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1915-22

1915-1922

352

151

68.

PHYTOCHEMICAL SCREENING, ANTIBACTERIAL AND ANTIOXIDANT POTENTIAL OF EXTRACTS OF MYRICA ESCULENTA LEAVES IN DIFFERENT SOLVENTS

Myrica esculenta Buch - Ham. ex D. Don has been used worldwide for the treatment of various ailments. The present work is an attempt to relate the presence of phytochemicals in leaves of M. esculenta with its antibacterial potential using seven different solvents for preparation of extracts. The preliminary phytochemical screening confirmed the presence of alkaloids, flavonoids, carbohydrates, tan...

B. Manners * and P. J. Handique

Department of Biotechnology, St. Edmund’s College, Shillong, Sikkim, Gangktok, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1923-32

1923-1932

260

159

69.

THE EFFECT OF CONSTANT LIGHTING ON THE ORGANIZATION OF CIRCADIAN RHYTHMS OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS AT AGE OF 6 MONTHS

The effect of constant lighting on the level of some hematological parameters and their daily dynamics was studied in male Wistar rats at the age of 6 months. It was found that staying in constant light for 3 weeks leads to a rise in hematocrit level, mainly due to an increase in the number of red blood cells, while a decrease in the oxygen-transporting properties of these cells is noted. An analy...

M. Lyudmila, K. Maria, K. Youri and A. David *

Researching Laboratory of Experimental Biology and Biotechnology, 24 Very Voloshinoyst, Mytischy, Moscow region, Russian Federation.

DOI: 10.13040/IJPSR.0975-8232.12(3).1933-38

1933-1938

223

115

70.

VIRTUAL SCREENING OF NEWER POTENTIAL COLONY STIMULATING FACTOR 1 INHIBITORS AS POTENT ANTIEPILEPTIC AGENTS

Background: Epilepsy is a chronic disorder that causes unprovoked, recurrent seizures like a sudden rush of electrical activity in the brain. Neuronal hyperexcitability in epilepsy is due to an imbalance between glutamate-mediated excitation and GABA-mediated inhibition. Aim: This prompted us to design newer CSF1R inhibitors as efficient therapeutic drugs for the treatment of epilepsy. Materials a...

R. Priyadharsini * A. Dharuman, P. Nithya, P. Shalini and G. Sumithra

College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1939-49

1939-1949

196

120