Volume 12 (2021) - Issue 3, March
Review Articles
CORONAVIRUS TO COVID-19 PANDEMIC: AN OVERVIEW
Coronaviruses wrapped with the layers of positive-sense RNA viruses specified by the club-like projections from their surface responsible for a variety of diseases in the animal kingdom. After the two historical episodes of coronaviruses i.e., severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, this time world strike...
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POTENTIAL ACTIVITY OF SPICES ON ACE2 EXPRESSION – A MINI REVIEW
Spices, nature's gift to mankind are the reservoir of secondary metabolites – alkaloids, flavonoids, saponins, tannins, glycerides, sulfides, and other oxygen/nitrogen compounds that can effectively treat viral infections, bacterial infections, and respiratory problems. Since ancient days they have been used for its anti-inflammatory, carminative, antioxidant, anti-clotting, anti-microbial, anti...
1849
718
BREAKTHROUGHS IN TRANSDERMAL NANOSTRUCTURED LIPID CARRIER DRUG DELIVERY SYSTEMS
The important barrier in transdermal drug delivery (TDD) is the Stratum corneum (SC), the outermost layer of the skin, which acts as an excellent protective physiological barrier. To boost the penetration or permeation of drugs through SC, several tactics have been used including passive and active methods of permeation or both in combination. This unwraps the opportunity to broaden the range of d...
1814
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PRONIOSOMAL GEL: A NOVEL THERAPEUTIC TOPICAL / TRANSDERMAL DRUG DELIVERY SYSTEM
Today, Nanotechnology is widely used for leading new dosage forms. Vesicular drug delivery system is expanding as one of advanced nanotechnology. Delivery of drugs using colloidal particulate carriers and liquid crystalline compact niosomal hybrid such as niosome and proniosomes has peculiar advantages over conventional dosage forms. Proniosomes is a dry formulation using suitable carrier coated w...
2293
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REVIEW ON DERIVING A HYPOTHESIS FOR ACHIEVING SUPERIOR BIOAVAILABILITY OF CURCUMIN AS AN ANTITUMOR AGENT
Curcumin, chemically 1,7-bis (4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione derived from Curcuma longa L. is an active chemical constituent used medicinally worldwide from ancient times. Though Curcumin enjoying the reputation of many pharmacological actions, it has certain setbacks with poor bioavailability. The poor water solubility is said to be the reason for poor bioavailability, rathe...
1529
608
A REVIEW ON TRADITIONAL MEDICINAL PLANTS USED AS ANTIDOTES IN THE TREATMENT OF SNAKE BITES IN INDIA
Envenoming and deaths resulting from snakebites are particularly important public health problems in the rural tropics. Snake envenomation is included since 2009 in the World Health Organization (WHO) list of Neglected Tropical Diseases, as this condition remains largely neglected by national and international health authorities. The only available specific treatment is antivenom therapy, which co...
1190
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THE STUDY ON OPTIMIZATION OF SOLID ORAL FLOATING TABLETS-A REVIEW
The motivation behind composing this review on floating drug delivery systems (FDDS) was to incorporate the ongoing research article with a unique spotlight on the key system of floatation to accomplish gastric maintenance. The ongoing advancements of FDDS, including the physiological and formulation factors influencing gastric maintenance, ways to deal with configuration single-unit, and numerous...
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HEALTHCARE TRANSFORMATION THROUGH PERSONALIZED MEDICINE
Excessive heterogeneity in the phenotypic expression of drug treatment response and adverse drug reaction is resolute by a complex interaction of multiple hereditary variants and environmental aspects. The complex nature of treatment response greatly increases the need for personalized medicine. Drug metabolizing enzymes show monogenic genetic polymorphism and influence drug response. Cytochrome P...
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ONGOING ADVANCEMENT IN THE COMPREHENSION OF MITOCHONDRIAL PRO-GRESSION WITH AN EXCEPTIONAL SPOTLIGHT ON ITS RELATIONSHIP WITH CANCER AND POSSIBLE THERAPEUTIC STRATEGY
Cancer is one of the main reasons of death around the world and the quantity of new incidents keeps on rising. Despite ongoing advances in conclusion and remedial systems, many malignancy-related passes happen, demonstrating the requirement for better treatments and symptomatic methodologies. Mitochondrial morphology is dependent on continuous fusion and fission strategies that are essential for m...
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Research Articles
EFFECTS OF ORAL ZINC SUPPLEMENTATION IN EARLY NEONATAL LIVE ON DEVELOPMENT OF OBESITY AND METABOLIC SYNDROME IN ALBINO RATS
Background: Zinc (Zn) is the most common trace element in eukaryote cells and the second most abundant trace element in human tissues and secretions after iron. Zinc is required for normal growth and development from in uteri to puberty. There is a lack of evidence on Zn as a potential therapeutic agent to reduce weight and improve metabolic parameters in obese adults. Aim: to evaluate Zn suppleme...
1327
612
DETERMINATION OF MACRO AND MICROELEMENTS CONTENTS IN GENTIANA MACROPHYLLA PALL. HERB
Macro and microelements are integrally linked to hormones, vitamins, amino acids, and enzymes in the human body. They affect the normal course of physiological processes. Some medicinal plants contain substantial contents of micro-and macro-elements, which makes it possible to use them purposefully for the prevention and treatment of various diseases. The target of the research was samples of G. m...
1359
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PHYTOCHEMICAL ANALYSIS AND MYCOBACTERICIDAL STUDIES OF THE LEAVES OF C. MUCRONATUM SCHUMACH. & THONN.
Combretum mucronatum Schumach & Thonn is a scandent shrub whose leaves are widely used by Ghanaians and other West-African herbalists for the treatment of various infectious and non-infectious diseases. It is used to treat wounds, coughs, dysentery, worm infestation, neurological disorders and bacterial infections. Some coughs are as a result of mycobacterial infection. Despite the success gai...
1276
653
DESIGN, SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NEWER POTENT APOLIPOPROTEIN E4 INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE
A major genetic suspect for Alzheimer's disease is the pathological conformation assumed by Apolipoprotein E4(Apo E4) through intramolecular interaction. The aim of the current study is to synthesize newer potent Apo E4 inhibitors. In the present study, with specific pharmacophoric features of three Hydrogen bond donors and three hydrophobic spheres, a large library of ligands was constructed for ...
1596
604
FRESH JUICE OF DRYNARIA QUERCIFOLIA RHIZOME FOR THE MANAGEMENT OF ARTHRITIS
Drynaria quercifolia rhizome (DQR) ethnomedicinal information shows the traditional usage of this rhizome for the treatment of body and joint pain, diarrhoea, typhoid, cholera, and skin diseases. The fresh juice of rhizome is still being consumed as an energy drink by tribes and localities of Tamil Nadu and Kerala. However, no investigations have been carried out to claim the anti-arthritic activi...
1455
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IN-SILICO ANALYSIS OF MTA1 AS DRUG TARGET AGAINST NATURAL ANTIOXIDANTS
The protein MTA1 with histone deacetylase activity is a member of the nucleosome remodeling complex encoded by the mta1 gene is frequently overexpressed in biologically aggressive epithelial neoplasms. MTA1 is a nuclear co-regulatory molecule that is highly expressed in many cancers and correlates with tumor metastasis and progression. MTA1 alters signaling events in the tumor micro-environment. M...
982
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FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF BACLOFEN
The present study was aimed to formulate and evaluate floating microspheres of Baclofen. The research work's objective was to retain Baclofen in the stomach for a prolonged period of time, which has absorption window in the upper gastrointestinal tract. The microspheres were prepared by solvent evaporation technique. A 32 full factorial was applied to investigate the combined effect of the two ind...
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ANTITUMORIGENIC EFFECT OF VARIOUS PARTS OF FICUS RACEMOSA IN DALTON LYMPHOMA ASCITES TUMOR INDUCED SWISS ALBINO MICE
Medicinal plants play an important role in the development of potent therapeutic agents. In recent years there has been an increased interest in using of herbal medicines. To assess the antioxidative and antitumorigenic efficacy of methanolic extract of bark, fruits, and leaves of Ficus racemosa in Dalton Lymphoma Ascites tumors transplanted Swiss albino mice. The results showed that the cytotoxic...
968
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A COMPARATIVE INVESTIGATION OF METHANOL AND SILVER NANOPARTICLES EXTRACTION FROM CORIANDRUM SATIVUM SEEDS FOR ANTIDIABETIC POTENTIALITY – IN-VITRO
Botanical name of coriander is Coriandrum sativum Linn. Coriandrum sativum belongs to the family Umbelliferae which is a highly reputed ayurvedic medicinal tree commonly known as Dhania. Essential oils, flavonoids, fatty acids, and sterols have been isolated from different parts of C. sativum so far. The phytochemical analysis of both methanol and AgNP’s extract was evaluated. Results revealed t...
916
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IDENTIFICATION OF POTENTIAL INHIBITOR AGAINST EXFOLIATIVE TOXIN A ASSOCIATED WITH STAPHYLOCOCCUS AUREUS INFECTION – A MOLECULAR DOCKING APPROACH
Staphylococcus aureus is a frequent colonizer of the human body as well as a serious human pathogen. It can cope with stress factors and acquire resistance to antibiotics, thus rendering treatment difficult. Discovering new treatments for this disease is urgently required, especially in view of the emergence of multiple drug resistant organisms and to reduce the total duration of current treatment...
942
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IN-SILICO STUDY OF TOXICITY MECHANISMS FOR METABOLITES OF PHYTO-COMPOUNDS FROM MUSA SP. COMPARED TO SYNTHETIC MEDICINE RANITIDINE
An in-silico attempt to predict rat oral acute toxicity, hepatotoxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor (NR) signaling, and stress response (SR) pathways of metabolites of synthetic medicine Ranitidine and flavonoids of Musa sp. The metabolites of common flavonoids and synthetic medicine were taken from literature, and the prediction was done by using ProTox-II webser...
2510
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IDENTIFICATION AND DOCUMENTATION OF EDIBLE INSECTS OF VESPA AFFINIS IN NAGALAND BY USING DNA BARCODE TECHNIQUES
DNA bar-coding is an ordered strategy that utilizes a little genetic marker in insect DNA to distinguish animal categories, as well as unidentified species. The present investigation manages the utilization of COI gene sequences in the distinguishing proof and documentation of edible insects in Nagaland. More than 2000 types of edible insects are recorded in more than 300 ethnic groups all around ...
1031
526
REINVESTIGATION OF SYNTHESIS OF ENOXAPARIN UNDER PTC CONDITIONS
Heparin is a mixture of glycosaminoglycan (GAG) chains originating from the porcine intestinal mucosa. It is used therapeutically as an anticoagulant for the treatment and prevention of thrombosis. Glyco-saminoglycans such as heparin (H) and heparan sulfate (HS) are considered attractive therapeutic agents because they modulate many biological processes and have been implicated in numerous patholo...
1062
864
ANTIMYCOBACTERIAL SCREENING OF SELECTED MEDICINAL PLANTS USING MTT AND THE MICROPLATE RESAZURIN ASSAY
Tuberculosis holds one of the top places on the list of the main cause of death in India. At times, the patients fail to respond to treatment with anti-Tb drugs, drug resistance being one of the reasons. The increasing incidence of MDR and XDR-TB highlights the urgent need to search for newer anti-Tb drugs. For last many years, plants have beneficial activity in a different types of diseases produ...
946
510
GASTRPROTECTIVE & ANTI-ULCER ACTIVITY OF SACCHARUM OFFICINARUM FRESH JUICE IN CHEMICAL INDUCED ULCER IN ALBINO RATS
Objects: In the present study the anti-ulcer activity of Saccharum officinarum fresh juice was investigated in the chemical-induced ulcer. The efficacy of the plant based juice was compared with standard reference anti-ulcer drug Ranitidine. Methods: The fresh juice collected from the plant of S. officinarum. Firstly, washes the sugarcanes well and peel the outer layer of the cane with a big knife...
1046
550
FORMULATION AND CHARACTERIZATION OF ECONAZOLE NITRATE LOADED TRANSFERSOMAL GEL FOR ANTIFUNGAL ACTIVITY
The aim of the present work is to formulate and characterize Econazole nitrate (EN) loaded transfersomal gel for antifungal activity. EN is a broad-spectrum imidazole antifungal agent that belongs to BCS Class II. Due to poor solubility, EN is incompletely absorbed after oral administration and bioavailability vary among individuals. Topical treatment of fungal infections is usually preferred, but...
1555
839
EFFECT OF BIOCOMPOSTED VEGETABLE AND GROUNDNUT SHELL WASTE ON THE GROWTH IMPACT OF PIGEON PEA (CAJANUS CAJAN (L.) MILL SP.)
Department of Botany, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, conducted a pot culture experiment for analyzing the effect of bio-composted groundnut shell and vegetable waste on the growth impact of Pigeon pea (Cajanus cajan (L.) Mill sp. Organic wastes and by-products are renewable forms of resources generated all over the world. The prese...
1117
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A STUDY ON TRADITIONAL DICOTS AS COMBAT TO WOUND MICROBIAL CLUSTERS
Antibiotic resistance emergence, as well as the Darwinism of up to the minute strains of ailment generating agents, is of grave concern to the global health community. Sustainable therapeutics of an ailment entails the amalgamation of contemporary pharmaceuticals or some potential prospective of novel drugs. Customarily employed medicative plants of Gopalganj community could be an enticing of drug...
936
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DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FENTANYL CITRATE BOTH IN BULK AND MICRO-EMULSION FORMULATION
Objective: Development of simple, rapid, and accurate UV spectrophotometric method for the estimation of Fentanyl citrate (FC) in a bulk and pharmaceutical dosage form. The proposed method was validated according to the guidelines of the International Conference on Harmonization and the Association of Official Analytical Chemists International. Methods: The method was based on the measurement of a...
1009
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ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF SECONDARY METABOLITE PRODUCED BY ENDOPHYTIC FUNGI ISOLATED FROM LANNEA COROMANDELICA (HOUTT.) MERR
Lannea coromandelica (Houtt.) Merr. which is known as Kayu Jawa in Bugis community, Indonesia has been widely used empirically for the treatment of wounds. Ethanol extract from its stem bark is known to have antibacterial, anti-inflammation, and antioxidant activity. The purpose of this study were to isolate, characterize, and determine the antioxidant and antimicrobial activity of the endophytic ...
1349
634
GC-MS AND FT-IR ANALYSIS OF METHANOLIC EXTRACT OF A MARINE CNIDARIAN ZOANTHUS SANSIBARICUS IN SEARCH OF BIOACTIVE COMPOUNDS
Present study was aimed to search bioactive functional groups and compounds in the whole animal extract of a marine cnidarians Zoanthus sansibaricus by FT-IR and GC-MS. The methanol extract was used to detect bioactive functional groups and compounds. GC-MS of the animal extract was done, and FTIR analysis was thereafter used to identify the functional groups. The bioactive components were identif...
1010
535
A NEW WAY OF METHOD ESTABLISH AND VALIDATED OF RELATED SUBSTANCE OF GLASDEGIB BY RP-HPLC AND ITS FORCED DEGRADATION STUDY
A novel, simple, and accurate, high-performance liquid chromatographic method has been a developed with quantitative analysis of Glasdegib using Waters X-Bridge C18 150 × 4.6mm, 3.5µ column with a flow rate of 1ml/min. The buffer containing 0.1% OPA and the mixture of two components like Buffer and Acetonitrile in the ratio of 50: 50 is used as mobile phase. The detection was carried out at 250n...
965
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MOSQUITO LARVICIDAL ACTIVITY OF HYPTIS SUAVEOLENS (L) POIT EXTRACTS PURIFIED FRACTION
Bio-pesticides are playing a very important role in controlling mosquitoes and their larvae. In the present scenario, chemical pesticides are causing several side effects on non-target organisms, particularly in men. Moreover, mosquitoes and their larvae become resistant to chemical pesticides; therefore, chemical pesticides are not much more effective. The conventional use of temephos and pyrethr...
1025
505
ACCELERATED STABILITY STUDY OF ARSENAZO III USED FOR DETECTION OF CALCIUM FROM BIOLOGICAL SYSTEM THROUGH UV-SPECTROPHOTOMETER, BIOCHEMISTRY ANALYZER, PH METER, HPLC AND HPTLC
Objective: Stability of In-vitro Diagnostics (IVDs) reagents was performed to check its quality standards, performance, and linearity. IVDs like Calcium reagent containing Arsenazo III were studied by Accelerated stability studies by considering temperature, pH, and light parameters. Materials and Methods: Stability data were obtained by using different instruments like UV spectrophotometer, Bioch...
1059
533
PHARMACOGNOSTIC AND PHYTOCHEMICAL STUDIES ON A RELIGIOUS HERB OCIMUM TENUIFLORUM L.
"The Queen of Herbs" – Tulsi (Ocimum tenuiflorum), is the most sacred herb of India, also known as the holy Basil, is ubiquitous in Hindu tradition. Tulsi has been revered in India for over five thousand years as a healing balm for body, mind, and spirit. It is known to bestow an amazing number of health benefits. Modern scientific research offers impressive evidence that Tulsi reduces stress, e...
1294
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EVALUATING THE PARAMETERS FOR SELECTING THE BEST METHOD FOR THE PRE-PARATION OF NANOCRYSTALS BY USING FUZZY ANALYTIC HIERARCHY PROCESS
The aim of this paper is to select the best method for the preparation of nanocrystals by using the fuzzy analytic hierarchy process (Fuzzy-AHP) methodology. The commonly used methods for the preparation of nanocrystals are Hydrosol, sonoprecipitation, spray freezing into liquid, and Nanomorph®. There are several parameters to take into consideration for the selection of the best method like oper...
873
420
STUDIES ON GC-MS PROFILING OF SOME SEAWEEDS OF MAHIM BEACH DIST. PALGHAR, MAHARASHTRA USING VARIOUS SOLVENTS
Objective: To investigate the bioactive constituents of Ulva lactuca, Sargassum prismaticum, and Sarconema filiforme using gas chromatography-mass spectrometry (GC-MS) analysis. Methods: 10 gm sample of each seaweed was successfully extracted with HPLC grade methanol and pet. ether with continuous shaking in a dark room for 36 h. The concentrated extracts were subjected to GC MS analysis. Results:...
980
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METOPROLOL, TELMISARTAN AND CLINIDIPINE IN TABLET
RP-HPLC method has been developed for separation and quantification of Metoprolol succinate, Telmisartan, and Clinidipine using Phenomenex Luna C18 column (150 mm × 4.6 mm, 5 µm) as a stationary phase with security guard cartridge C18 (4 × 3 mm) and acetonitrile: methanol: phosphate buffer pH 7.5 (45:30:25) as a mobile phase by isocratic elution at the flow rate of 1.0 ml/min. The detection was...
1729
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ANTIMUTAGENIC ACTIVITY OF POMEGRANATE EXTRACT AND 2 – METHOXY-ESTRADIOL IN COMBINATION ON SWISS ALBINO MOUSE – MUS MUSCULAS
Pomegranate extracts (PGEs) exhibit antioxidative, antiproliferative, and antineoplastic activities. 2-Methoxyestradiol (2-ME), the end metabolite of 17β estradiol (E2), an antiangiogenic agent, inhibits tumor growth. Our earlier investigations demonstrated that aqueous PG extract (PGE) in combination with 2-ME showed antineoplastic effect on Sarcoma-180 tumor cells. The present paper has been or...
910
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PHYSICOCHEMICAL AND PHYTOCHEMICAL ANALYSIS OF METHANOLIC EXTRACT OF LEAVES AND FRUITS OF FLACOURTIA JANGOMAS (LOUR.) RAEUSCH
Plants have been used extensively as medicine for the treatment of various ailments for centuries. The present study was conducted to analyze physicochemical and phytochemical parameters of leaves and fruit of Flacourtia jangomas (Lour.) Raeusch Physicochemical profile showed the high total ash, water-soluble ash, and acid-soluble ash content in F. jangomas leaf when compared to the fruit. The w...
1569
814
GC-MS AND FT-IR ANALYSIS OF METHANOL FRUIT EXTRACT OF FICUS RACEMOSA AND FICUS AURICULATA
The fruits of the plant Ficus racemosa and Ficus auriculata are consumed as a wild edible fruit and have also been used extensively in traditional medicine to treat various illnesses ranging from diarrhea, dysentery, jaundice to diabetes, piles, asthma, and urinary diseases. Gas Chromatography-Mass Spectro-metry (GC-MS) analysis of methanol extract of the fruits was carried out to identify the pos...
1319
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PHYTOPHARMACOGNOSTICAL STUDY OF SOME SELECTED ANTITUBERCULOSIS PLANTS AND STUDY OF ITS CYTOTOXICITY SCREENING USING VERO CELL LINE
Tuberculosis (TB) is one of the leading infectious diseases and health burdens in the world. One-third of the world’s population, including 40% from India, is estimated to be infected with tuberculosis. Current studies have indicated the urgent need for the development of new, safe, and efficacious drugs to help reduce the global burden of tuberculosis. Novel antimycobacterial scaffolds from na...
995
517
DOCKING – BASED VIRTUAL SCREENING OF LIPINSKI COMPLIANT 2 -ARYLQUINA-ZOLIN – 4 – ONE DERIVATIVES: A MOMENTUM TO THE DISCOVERY OF NOVEL EGFR INHIBITORS
The epidermal growth factor receptor (EGFR), which is a potential anticancer drug target, is over-expressed in non-small-cell lung cancer (NSCLC). The present study is an attempt to explore the human EGFR (protein data bank code: 1M17) inhibition potential of Lipinski compliant compounds possessing 2-arylquinazoli-4-one scaffold with chalcone structural motif; by docking analysis, using Auto Dock ...
2379
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EFFECT OF SHORT TERM DIETARY ZINC DEFICIENCY AND ZINC SUPPLEMENTATION ON WISTAR RAT ERYTHROCYTE: BIOCHEMICAL STUDIES
Deficiency of zinc has been reported in developed and developing countries due to low zinc intake, which also accounts for crops grown in low zinc areas. 2 billion people still remain at risk of zinc deficiency affecting all age groups in spite of proven benefits of adequate zinc nutrition. The study evaluates the effect of dietary zinc deficiency on male Wistar rat erythrocytes for 2-, 4- and 6 w...
978
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SYNTHESIS OF 2-(2-(2-(BIS (2-CHLOROETHYL) AMINO) ETHOXY) BENZYLIDENE) BENZOFURAN – 3(2H) – ONE DERIVATIVES ON BASIS OF BENZALDEHYDES AND ACETOPHENONES FOR ITS CYTOTOXIC ACTIVITY
Benzofuranones and nitrogen mustards have been reported as highly potential alkylating agents; with this evidence, the synthesis of some benzofuranones fused with nitrogen mustards was planned and was subjected to in-vitro cytotoxic studies. Substituted benzofuranones were synthesized by condensation of 2-hydroxy benzaldehydes and substituted 2-hydroxy acetophenones and further fused with nitrogen...
950
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ISOLATION OF AROMATIC AND MEDICINAL COMPOUNDS FROM ISODON NILGHERRICUS (BENTH.) H. HARA – AN ECONOMIC ASPECT
The secondary metabolites being defensive function in plants, the men also thought of using same to defend the chronic diseases by crud drugs or with some organic aromatic molecules. The phenyl groups and other functional groups are bonded together, forming aromatic organic molecules. These molecules are used in perfumes and medicines. The qualitative and quantitative aromatic and medicinal compou...
902
473
CHEMICAL COMPOSITION, ANTIGENOTOXIC, ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITIES OF N-BUTANOL FRACTION FROM PTERIS VITTATA L.
Pteris vittata L., a fern species in the Pteridoideae subfamily of Pteridaceae, is known to possess various medicinal properties. P. vittata is used as a folk medicine in the Eastern Ghats of Tamil Nadu, Western Ghats, and Vindhyan region of Madhya Pradesh, India. The present study was undertaken to evaluate antigenotoxic, antioxidant, and antiproliferative potential of P. vittata L. HPLC analysis...
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NEPHROPROTECTIVE ACTIVITY OF CHLOROFORM EXTRACT OF ABRUS PRECATORIUS IN RATS
This study seeks to evaluate the nephroprotective activity of chloroform extract of Abrus precatorius against gentamycin-induced nephrotoxicity in rats. Albino rats of Wistar strain of both sexes were used for the study and grouped into five, containing 6 animals. The study was performed for 14 days. For induction of nephrotoxicity, gentamycin and paracetamol were used, and the plant extract was g...
999
543
PHYTOCHEMICAL INVESTIGATION, ISOLATION AND CHARACTERIZATION OF BETULIN FROM LEAF OF GYMNOSPORIA MONTANA
Ethnomedicinal plant-like Gymnosporia montana belonging to the family Celastraceae is commonly known as Vikalo in Gujarat. Ethanomedicinally, fresh leaves of Vikalo are chewed in trible regions of Gujarat to cure jaundice. Phytochemical screening of the plant showed the presence of phytoconstituents like phenol, flavonoids, alkaloids, triterpenoids, and saponin. The present study was undertaken fo...
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MICROSCOPIC CHARACTERISTICS AND LEAF CONSTANT NUMBERS OF SELECTED DERRIS SPECIES IN THAILAND
Medicinal plant identification is necessary for ensuring their efficacy and safety in the quality control of herbal products. The genus Derris belongs to the Leguminosae family. This study aimed to investigate the microscopic characteristics of selected Derris species in Thailand. Eight Derris species (D. amoena, D. elliptica, D. indica, D. malaccensis, D. recticulata, D. scandens, D. solorioides,...
3135
810
NOVEL METHOD FOR SEPARATION AND QUANTIFICATION OF POTENTIAL IMPURITIES BY RP-HPLC FROM KSM STAGE TO API STAGE OF DABIGATRAN MESYLATE
Dabigatran mesylate is a novel oral anticoagulant that works by blocking the clotting protein thrombin. The present work describes the separation and quantification of potential impurities in a single HPLC method, which are generated from raw materials to API synthesis. This method is capable of separating and quantifying the fourteen impurities, produced from the intermediate stages to final drug...
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EVALUATION OF PROTECTIVE EFFICACY OF PUNICA GRANATUM ON SHORT TERM Β-CYFLUTHRIN TOXICITY ON REPRODUCTIVE TISSUE OF MALE MICE
Pyrethroids are among the most extensively used insecticide. The widespread use of these synthetic pesticides has stimulated research into the possible existence of adverse effects related to reproductive activity. The present study was, therefore, undertaken to assess the effects of β- Cyfluthrin, a type II synthetic pyrethroid on testes, the main organ of male reproduction. Animals were divided...
1934
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FORMULATION AND DEVELOPMENT OF QUERCETIN AND MONOAMMONIUM GLYCYRRHIZINATE LOADED GEL FOR THE TREATMENT OF MOUTH ULCER DISEASE
Diagnosis of oral ulcerative lesions might be quite challenging. Oral ulcerative lesions were categorized into three major groups as acute, chronic, and recurrent ulcers. Helicobacter pylori (H. pylori) have been found in the oral cavity and stomach, and its infection is one of the most frequent worldwide. There is a close relation between H. pylori infection in the oral cavity and the stomach. H....
1435
967
ISOLATION, IDENTIFICATION OF NON-POLAR TERPENES AND TOTAL ANTIOXIDANT ACTIVITY FROM CHLOROFORM EXTRACT OF BOUGAINVILLEA GLABRA LEAVES
This study reports the isolation and antioxidant activity of non-polar terpenes extracted from the leaves of Bougainvillea glabra choicy. To characterize the phytochemical constituents of Bougainvillea glabra leaves using the GC-MS method. The 95% ethanol extract was filtered, distilled, and concentrated to obtain the solid greenish residue. The residue was further fractioned by n-hexane, chlorofo...
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ANTIOXIDANT ACTIVITY OF CASSIA AURICULATA AND CASSIA FISTULA EXTRACT ALONG WITH WOUND HEALING ACTIVITY OF ITS POLYHERBAL FORMULATION
Due to emergent concerns about unhealthy consequences of chemicals in the health industry, the interest towards natural and herbal substances has been growing every day. In this study, the antioxidant effect of Cassia fistula [CFF] and Cassia auriculata [CAF] extract was evaluated. Also discover wound healing activity of polyherbal formulation (CFF and CAF). The antioxidant activity of the extract...
1161
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IN-VITRO EVALUATION OF ANTIULCER ACTIVITY OF AQUEOUS EXTRACT OF MALVASTRUM TRICUSPIDATUM
There are several factors that may induce ulcers in human beings such as stress, chronic use of anti-inflammatory drugs, etc. Though in most cases, the etiology of ulcer is unknown, it has generally accepted that it is the result of an imbalance between aggressive factors and maintenance of the mucosal integrity through the endogenous defense mechanism. Thus, the search for a safe anti-ulcer drug ...
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FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF HYDROGEL BASED CONTROLLED RELEASE MATRIX TABLET OF PROPRANOLOL HYDROCHLORIDE
Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCL is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study hydrogel matrix...
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MOLECULAR DOCKING STUDY ON SARS-COV-2 PROTEASE INHIBITION BY EXPLORING BIOACTIVE COMPOUNDS FROM DIFFERENT PLANTS
The novel human coronavirus which has been designated as SARS-CoV2 initially appeared in December 2019 in Wuhan, China causing a respiratory illness called COVID-19. The SARS-CoV2 is a β coronavirus belonging to the family Coronaviridae is a global public health emergency infecting many people all around the world, especially in India with more than 10.8 million cases. Henceforth there is an urge...
1221
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DISSOLUTION METHOD DEVELOPMENT AND VALIDATION FOR DERACOXIB CHEWABLE TABLET USING UV SPECTROPHOTOMETRIC METHOD
Deracoxib is a coxib class of Non Steroidal Anti-Inflammatory Drug (NSAID). Like other NSAIDs, its effects are caused by inhibition of Cyclooxygenase (COX) enzymes. Deracoxib causes greater inhibition of COX-2 than of COX-1. The aim of this proposed method was to develop and validate the UV spectrophotometric method for the routine quality control check of API containing 25 mg Deracoxib intablet...
1323
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SYNTHESIS, PHARMACOKINETIC AND PHARMACOLOGY OF MUTUAL PRODRUGS OF FENBUFEN AND PROPYPHENAZONE
Mutual prodrugs of fenbufen and propyphenazone were synthesized with the aim of getting better therapeutic index through avoidance of gastrointestinal problems and to check the efficiency of release of parent drug in the presence of spacer. These mutual pro-drugs were synthesized by direct esterification and by using glycine as a spacer. The title compounds (FP1 & FP2) were characterized by sp...
1045
597
FORMULATION DEVELOPMENT AND EVALUATION OF ATORVASTATIN CALCIUM LIQUISOLID TABLETS
The solubility and dissolution properties of any drug are vital determinants of its oral bioavailability. The aim of this study was to increase the dissolution rate of poorly soluble drug Atorvastatin calcium by delivering the drug as a liquisolid compact, prepared by using PEG as a solvent, Avicel PH 102 as carrier, silica, and lactose are used as coating materials. Sodium starch glycolate was us...
1503
1003
FORMULATION AND STATISTICAL OPTIMIZATION OF S-SMEDDS OF NICARDIPINE HYDROCHLORIDE BY USING BBD AND PCA DESIGN
The study purpose is to further enhance the rate of dissolution for poorly water-soluble drug Nicardipine Hydrochloride by dissolving NH in surfactant, Co-surfactant, and oil; phase diagram was plotted by using oil (Capmul MM C8 EP), surfactant (Labrasol), and co-surfactant (PEG 400) through which a region called microemulsifying region was obtain. The batches were optimized by holding a 3-factor ...
1080
598
ISOLATION AND STRUCTURAL ELUCIDATION OF IMPURITY IN NEBIVOLOL
In the synthesis of Nebivolol [a mixture of (1RS, 1' RS)-1,1'-{(2RS, 2' SR)-bis(6-fluoro 3, 4-dihydro-2H-1-benzopyran-2-yl)} -2,2'-iminodiethanol] having four chiral centers, one crucial isomeric impurity at 0.88 RRT was observed in HPLC related substance analysis in gradient HPLC method. This impurity was isolated from synthesized crude impurity substance by preparative HPLC with chiral normal ph...
1165
904
GREEN SYNTHESIS OF SILVER NANOPARTICLE BY USING TINOSPORA CORDIFOLIA LEAF EXTRACT AND ITS ANTIMICROBIAL PROPERTY
Tinospora cordifolia is one of the best medicinal plants holds most prominent place in Ayurveda Rasayana herbs and it also known as “rejuvenate herbs” because of its medicinal properties. It has been found to exhibit anti-microbial properties, its anti-microbial feature found in root, stem, and leaf extracts on pathogenic micro-organisms. Green synthesis of AgNPs can potentially eliminate chem...
2103
919
BIOGAS PRODUCTION FROM CO-DIGESTION OF TEXTILE DYE AND RICE HUSK USING AGARICUS HETEROCYSTIS
The waste generated from the textile industry is used for the production of biogas under the anaerobic digestion method. This study investigated the effect of various parameters such as Temperature 27 °C – 31 °C, pH 8-10, Inoculum concentration 35-55 ml on the textile dye with rice husk by the Agaricus heterocystis for biogas production using Response surface methodology. Maximum biogas yield ...
1021
487
OCCURRENCE OF ASPERGILLUS FLAVUS AND AFLATOXIN B1 IN PADDY AND IT MILLING FRACTIONS WITH REFERENCE TO NORMAL AND CONTROLLED MILLING ENVIRONMENT
The contamination of Rice and its by-products with storage fungi, especially toxigenic Aspergillus flavus and Aflatoxin B1 leads to potential health hazard to human and domestic animals. Therefore, the present investigation was focussed on the comparative analysis of the fungal contamination with A. flavus and Aflatoxin B1 in Raw and Parboiled paddy and its milling fractions like Husk, Brow Rice, ...
908
479
ANTI-BACTERIAL EFFICACY OF PHYTOGENIC SILVER AND GOLD NANOPARTICLES OF LANTANA CAMARA. LINN AGAINST ENTERIC PATHOGENS
Antibiotic resistance could be a natural phenomenon that occurs when an antibiotic loses its ability to control or kill the bacterial growth; in other words, the bacteria become "resistant" and still continue to multiply in the presence of therapeutic levels of an antibiotic. Nano-technology is one of the foremost active areas in modern science. Nano particles exhibit a completely new or improved ...
920
508
ADVERSE DRUG REACTION MONITORING AMONGST DIABETIC PATIENTS OF TERTIARY CARE CENTRE OF NORTHERN INDIA RELATED TO ANTI-DIABETIC DRUGS
Diabetes mellitus caused by inherited and/or acquired deficiency in insulin production or by the development of insulin resistance. This is chronic as well as moderately increasing day by day in developing countries as well as globally and has reached about to the epidemic ratio, and now it is a matter of worry for the populations. This deficiency results in increased blood glucose concentrations,...
1395
645
PHYTOCHEMICAL SCREENING, ANTIBACTERIAL AND ANTIOXIDANT POTENTIAL OF EXTRACTS OF MYRICA ESCULENTA LEAVES IN DIFFERENT SOLVENTS
Myrica esculenta Buch - Ham. ex D. Don has been used worldwide for the treatment of various ailments. The present work is an attempt to relate the presence of phytochemicals in leaves of M. esculenta with its antibacterial potential using seven different solvents for preparation of extracts. The preliminary phytochemical screening confirmed the presence of alkaloids, flavonoids, carbohydrates, tan...
1157
705
THE EFFECT OF CONSTANT LIGHTING ON THE ORGANIZATION OF CIRCADIAN RHYTHMS OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS AT AGE OF 6 MONTHS
The effect of constant lighting on the level of some hematological parameters and their daily dynamics was studied in male Wistar rats at the age of 6 months. It was found that staying in constant light for 3 weeks leads to a rise in hematocrit level, mainly due to an increase in the number of red blood cells, while a decrease in the oxygen-transporting properties of these cells is noted. An analy...
931
427
VIRTUAL SCREENING OF NEWER POTENTIAL COLONY STIMULATING FACTOR 1 INHIBITORS AS POTENT ANTIEPILEPTIC AGENTS
Background: Epilepsy is a chronic disorder that causes unprovoked, recurrent seizures like a sudden rush of electrical activity in the brain. Neuronal hyperexcitability in epilepsy is due to an imbalance between glutamate-mediated excitation and GABA-mediated inhibition. Aim: This prompted us to design newer CSF1R inhibitors as efficient therapeutic drugs for the treatment of epilepsy. Materials a...
882
447