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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 9 (2018) - Issue 5, May

Review Articles

 
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1.

GREEN TEA (CAMELLIA SINENSIS) AND ITS ANTIOXIDANT PROPERTY: A REVIEW

Tea (Camellia sinensis) is one of the most widely consumed beverages in the world. Tea extracts are source of polyphenols, which are antioxidant components. Green tea phenolic compounds are predominately composed of catechin derivatives, although other compounds such as flavonols and phenolic acids are also present in lower proportion. The main catechin compounds found in green tea are (-) Epigall...

H. Vishnoi *, R. B. Bodla and R. Kant

Delhi Pharmaceutical Science and Research University, Pushp Vihar, New Delhi, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1723-36

1723-1736

2023

897

2.

A JOURNEY OF DIETARY NITRATE AS A HEALTH PROMOTER

Dietary nitrate has been demonstrated to have a range of beneficial vascular effects, including reducing blood pressure, reduction in pulse wave velocity, regulation of cerebral blood flow, enhancing exercise performance in healthy individuals, stimulating angiogenesis and vasculogenesis etc. Earlier studies with nitrate or nitrite also demonstrate the synergistic effects against ischaemia-reperfu...

R. T. Rana, S. Chopra, G. Rakhra and S. N. Singh*

Nutrition Division, Defence Institute of Physiology and Allied Sciences, DRDO, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1737-44

1737-1744

1558

526

3.

ANNONA SQUAMOSA LINN. (CUSTARD APPLE): AN AROMATIC MEDICINAL PLANT FRUIT WITH IMMENSE NUTRACEUTICAL AND THERAPEUTIC POTENTIALS

Alterative medication and natural remedies have been used from ancient time for the treatment and wellbeing of human. Medicinal plants are considered to be effective and for most important for the human health. Some of the natural medicinal plants are so common that we use them in daily life without knowing their medicinal importance. Annona squamosa belonging to the family Annonaceae is the best ...

M. Zahid *, M. Mujahid, P. K. Singh, S. Farooqui, K. Singh, S. Parveen and M. Arif

Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1745-59

1745-1759

3753

686

4.

MICROSPHERES AS CONTROLLED DRUG DELIVERY SYSTEM: AN UPDATED REVIEW

Oral modified or controlled dosage forms have always proven to be more effective alternative to conventional or immediate release dosage forms. Controlled or modified drug delivery systems offer numerous advantages of delivering a drug to the body in a précised manner with an aim to minimize its unwanted side effects and maximize its benefits. Targeted drug delivery systems target a particular si...

S. Saini, S. Kumar, M. Choudhary, Nitesh and V. Budhwar *

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1760-68

1760-1768

1994

511

Research Articles

 
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5.

CHARACTERISTIC AND OPTIMIZED USE OF BIOACTIVE COMPOUNDS FROM GLORIOSA SUPERBA AND ALBIZIA AMARA WITH APOPTOTIC EFFECT ON HEPATIC AND SQUAMOUS SKIN CARCINOMA

Background: Cancer is still a dreadful disease, the treatment ranges with difficulties like strong side effects, shortage of donor and organs. In relation, plants and its chemical properties will provide an efficient source in the innocuous treatment for cancers. Objectives: To identify and isolate bioactive compounds from Gloriosa superba tubers and Albizia amara leaves with anti-cancer property ...

F. A. Jayakumar*, S. E. Simon, Y. W. Yan and P. W. Yap

Department of Biosciences, School of Science and Engineering, Malaysia, University of Science and Technology (MUST), Kota Damansara, Petaling Jaya, Selangor, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.9(5).1769-78

1769-1778

1610

389

6.

CYTOTOXIC AND ANTIVIRAL ACTIVITY OF RIBES UVA CRISPA LINN. AND RIBES MULTIFLORUM KIT. EX ROMER AND SCHULTES EXTRACTS

ABSTRACT: To find new antiviral agents from natural sources, methanol and aqueous extracts   of   leaves   and   fruits of Ribes uva -crispa and Ribes multiflorum naturally grown in Turkey were investigated as in vitro to reveal their antiviral activities against Herpes simplex virus type 1. All experiments were performed in 96-well plates and results were measured with XTT-based colorimet...

R. Duman, H. H. Doğan *, M. Dinç and P. Tuncer

Department of Biology, Faculty of Science, Selçuk University, Konya, Turkey.

DOI: 10.13040/IJPSR.0975-8232.9(5).1779-87

1779-1787

1545

388

7.

SYNERGISTIC OLIGODYNAMIC EFFECT OF MYCOGENIC BIMETALLIC NANOPARTICLES WITH DAPTOMYCIN FOR CONTROLLING PATHOGENS

Bimetallic nanoparticles have several useful opto-electronic and catalytic properties that are different from those of monometallic nanoparticles. The development of non-toxic and eco-friendly protocols for the synthesis of bimetallic nanoparticles is a still less explored area. In the present study, bimetallic silver-gold nanoparticles were synthesized using Trichoderma reesei (NCIM 992). An effe...

I. Chakravarty, P. Narasimha, S. Singh, K. Kundu, P. Singh and S. Kundu*

School of Biochemical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1788-96

1788-1796

1321

330

8.

FORMULATION, DESIGN AND CHARACTERIZATION OF MUCOADHESIVE BUCCAL FILM OF NEBIVOLOL USING FACTORIAL DESIGN

The present investigation was to formulation and development of fast dissolving mucoadhesive buccal film of nebivolol by using solvent casting method. Nebivolol is a third-generation cardio selective β1-blocker undergoes extensive metabolism in the liver, gastrointestinal disturbance, abdominal pain after its oral administration and resulting in to a poor (10-12%) bioavailability. In order to imp...

A. J. Shinde*, D. S. Waghmare, R. S. Dalvi and H. N. More

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1797-05

1797-1805

1679

389

9.

PHYTOCHEMICAL CONSTITUENTS AND ANTIDIABETIC PROPERTIES OF SYZYGIUM CUMINI LINN. SEED

The present study was undertaken to investigate some organic phytochemicals, fatty acids, toxic metals and evaluate lipidemic and antidiabetic activity of a herbal medicine and its one constituent Syzygium cumini seed. Antidiabetic and lipidemic activity of this medicine and seed extract was studied on streptozotocin induced type 2 diabetic model rats. From chemical investigation carbohydrates and...

N. M. Proma, J. Naima, M. R. Islam, J. A. Papel, M. M. Rahman and M. K. Hossain*

Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.9(5).1806-14

1806-1814

2207

443

10.

CYTOTOXIC AND ANTI-PROLIFERATIVE EFFECTS OF RHODODENDRON PONTICUM L. EXTRACT ON RAT GLIOMA CELL LINE (F98)

The genus Rhododendron has been widely used in traditional medicine. Rhododendron ponticum L. (R. ponticum) contains grayanotoxins with diterpene qualities. The aim of this study was to investigate in vitro cytotoxic and antiproliferative effects of R. ponticum L. extract on glioma in a rat glioma cell line (F98) and to calculate the amounts of grayanotoxins I and III. Rhododendrons were gathered ...

E. K. Bilir, S. Sevin *, H. Tutun, M. E. Alcigir and E. Yarsan

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.

DOI: 10.13040/IJPSR.0975-8232.9(5).1815-20

1815-1820

1574

277

11.

ANTIDIABETIC EFFECT OF n-HEXANE FRACTION OF HYDRO-METHANOLIC EXTRACT OF TAMARINDUS INDICA LINN. SEED IN STREPTOZOTOCIN-INDUCED DIABETIC RAT: A CORRELATIVE APPROACH WITH IN VIVO AND IN VITRO ANTIOXIDANT ACTIVITIES

The present study was carried out to evaluate antidiabetic as well as in-vivo and in-vitro antioxidant activities of n-hexane fraction of Tamarindus indica Linn. seed (T. indica) in streptozotocin (STZ) induced diabetic rat. Oral administration of n-hexane fraction at the dose of 100 mg/kg body weight for 28 days prevented significantly the STZ-induced hyperglycemia. The plasma insulin and C-pepti...

R. Maiti *, D. De and D. Ghosh

Department of Physiology, Bankura Christian College, Bankura, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1821-30

1821-1830

3203

418

12.

HYDROGEL BASED COLON TARGETED DELIVERY OF RABEPRAZOLE SODIUM

The aim of this research was to develop controlled and sustained release formulation of hydrogel beads containing rabeprazole sodium, and to study the effects of Eudragit S100 coating on the release of rabeprazole sodium. The main objective was to develop a colon targeted drug delivery system to minimize - drug release in the upper gastro intestinal (GI) tract as well as to minimize GI adverse eff...

Y. Kumar, B. K. Singh, A. Kumar * and R. S. Padiyar

Department of Pharmaceutical Sciences, Kumaun University Campus, Bhimtal, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1831-38

1831-1838

509

224

13.

VARIATION IN MEMBRANE ELECTROCHEMICAL POTENTIAL OF PLASMODIUM INFECTED ERYTHROCYTES

Membrane electrochemical potential or zeta potential (ZP) is a feature of the molecular profile of the cell membrane and the two-dimensional arrangement of its charge-bearing molecules. Plasmodium species, the causative agents of malaria, are intracellular parasites that remodel host erythrocytes by expressing their own proteins on erythrocyte membranes. In the present study the variation in the Z...

Y. M. Charde * and J. G. Avari

Department of Pharmaceutical Sciences, R. T. M. Nagpur University, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1839-43

1839-1843

1091

213

14.

STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF EPALRESTAT AND PREGABALIN IN BULK AND TABLET DOSAGE FORM

A new  simple, sensitive, precise, accurate and stability indicating RP-HPLC method  has  been developed for the simultaneous determination of  epalrestat and pregabalin in combined tablet dosage form. The chromatogram was achieved with STD Discovery column 250 × 4.6 mm, 5m and mobile phase containing 0.1% ortho phosphoric acid buffer and acetonitrile taken in the ratio of 45: 55 was pumped t...

S. A. Parameswari * and G. Arunamma

Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupathi, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1844-50

1844-1850

851

301

15.

FORMULATION AND EVALUATION OF FLURBIPROFEN OCULAR IN-SITU GEL

Conventional ophthalmic preparations exhibit poor bioavailability due to the rapid precorneal elimination of the drug, and the physiological constraints imposed by the protective mechanisms of the eye lead to the low absorption of the drugs resulting in a short duration of the therapeutic effect. In order to increase the residence time of the drug in-situ gelling systems were prepared and instille...

S. K. Aligeti *, R. K. Jampala and J. Vinaya

Vaageswari College of Pharmacy, (Affiliated to JNTUH, Hyderabad), Karimnagar - 505481, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1851-56

1851-1856

811

285

16.

STUDY OF CLINICAL AND HISTOPATHOLOGICAL PATTERN, SEVERITY, CAUSALITY AND COST ANALYSIS IN HOSPITALISED PATIENTS WITH CUTANEOUS ADVERSE DRUG REACTIONS IN A TERTIARY CARE HOSPITAL

Objectives: To assess clinical and histopathological patterns, causative drugs, causality, severity and cost of treating cutaneous adverse drug reactions (CADRs) among patients admitted in tertiary care teaching hospital. Methods: In a prospective hospital-based study over a period of one year (June 2015- June 2016), CADRs of patients admitted to the dermatology department were recorded. The data ...

D. G. Kurle, S. V. Jalgaonkar *, V. N. Daberao, S. B. Chikhalkar and S. B. Raut

Department of Pharmacology and Therapeutics, Seth GS Medical College and KEM, Hospital, Parel, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1857-64

1857-1864

700

294

17.

FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY SYSTEM OF FLURBIPROFEN FOR TREATMENT OF RHEUMATOID ARTHRITIS

In this present research work, the aim was to develop ileo-colonic targeted mini-tablets filled capsule system of flurbiprofen for treatment of rheumatoid arthritis. In the present study pH independent colon targeted system was developed and evaluated. SMEDDs of poorly water soluble drug flurbiprofen were prepared to enhance its dissolution rate and bioavailability. Mini-tablets of flurbiprofen we...

S. Bhilegaonkar * and R. Gaonkar

Department of Pharmaceutics, P.E.S΄s Rajaram and Tarabai Bandekar College of Pharmacy Farmagudi, Ponda, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1865-77

1865-1877

1500

296

18.

SCREENING OF BIOACTIVE COMPOUNDS FROM LEAF OF CENCHRUS CILIARIS L. FROM THAR REGION OF RAJASTHAN, INDIA

Cenchrus ciliaris L. (Poaceae) commonly known as “Dhaman grass”, is a common famine food used during drought and scarcity of food in Rajasthan. The present investigation was carried out to determine the phytochemical composition of leaf of C. ciliaris using gas chromatography - mass spectrometry technique. The mass spectrum of the compounds found in the extract was matched with the national in...

S. Arora * and G. Kumar

Department of Botany, Jai Narain Vyas University, Jodhpur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1878-85

1878-1885

653

255

19.

ISOLATION AND CHARACTERIZATION OF BIOFILM FORMING BACTERIA FROM URINARY TRACT INFECTED PATIENTS

A biofilm is a microbial determined sessile group portrayed by cells that are irreversibly appended to a substratum or interface or to each other. Biofilms are the main cause for increase in virulence and antibiotic resistance of microorganisms. Both gram positive and gram negative pathogens are known to produce biofilms. Due to the production of biofilm, the bacteria adhere to the surface strongl...

P. K. Prasad, P. Sharma and P. Shlini *

Department of Chemistry (PG Biochemistry), Mount Carmel College Autonomous, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1886-94

1886-1894

1368

220

20.

MOLECULAR MODELLING AND MOLECULAR DOCKING STUDIES OF CYP450 INHIBITORS

The present study explains computational methods to design 3D structure of “Cytochrome P450 4A11” of Homo sapiens enzyme using the sequence available from Uniprot (Uniprot KB - Q02928). Homology modelling study was performed to generate a 3D model of Cytochrome P450 protein. The model was developed by using Modeler 9.17 software tool. The developed model was further docked with already existin...

S. Gujjula*, D. Jayasree and P. Y. Swamy

Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1895-01

1895-1901

488

237

21.

ANTICANCER POTENTIAL OF LEAFLESS MISTLETOE (VISCUM ANGULATUM) FROM WESTERN GHATS OF INDIA

Phenolics have been shown to attenuate the initiation and progression of cancer. Owing to the parasitic nature, mistleoes are a rich source of phenolics and flavonoids. European mistletoe (Viscum album) formulations provide the first line of treatment for cancer by stimulating the immune system and improve the quality of life. In fact, host-associated variation has been shown to affect the therape...

S. Sharma, R. S. Sharma, M. M. Sardesai and V. Mishra*

Bioresources and Environmental Biotechnology Laboratory, Department of Environmental Studies, University of Delhi, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1902-07

1902-1907

663

240

22.

PHARMACOGNOSTICAL EVALUATION AND PHYTOCHEMICAL ANALYSIS OF DELONIX REGIA RAFIN. STEM BARK

Delonix regia Rafin. belonging to family Fabaceae and subfamily Caesalpinioideae is flowering plant native to Madagascar and East Africa. Delonix regia reported to have anti-diarrhoeal, anti-inflammatory, antioxidant, hepatoprotective and antimicrobial activity. The present study was carried out to establish the pharmacognostical studies, physico-chemical parameters along with preliminary phytoche...

S. Singh * and Sonia

Department of Pharmaceutical Sciences, Guru Jambheshwer University of Science and Technology, Hisar, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1908-12

1908-1912

672

227

23.

ADVERSE DRUG INTERACTIONS IN ELDERLY HOSPITALIZED PATIENTS: A PROSPECTIVE ANALYSIS

Objective: To determine the incidence, characteristics, predictors and cost associated with the management of adverse drug interactions (ADIs) in elderly population. Methods: The prospective, intensive and interventional study included all patients taking at least two medications who were elderly admitted to medicine or surgery wards of a tertiary care hospital and were followed untill discharge. ...

A. S. George, M. Ramesh* and J. Sebastian

Department of Pharmacy Practice, JSS College of Pharmacy, Jagadguru Sri Shivarathreeshwara University, Sri Shivarathreeshwara Nagar, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1913-20

1913-1920

647

246

24.

3D QSAR AND MOLECULAR DOCKING STUDIES OF FLAVONOIDS AS SPLEEN TYROSINE KINASE INHIBITORS

Spleen tyrosine kinase (Syk) is a member of tyrosine kinase family protein. Syk protein plays a vital role during intracellular signal transduction from high affinity IgE receptor (FcεRI) in allergic reaction. Flavonoids are well known compounds for their anti-allergic properties. In this present work, thirty-four structurally similar flavonoids are investigated as Syk inhibitors by using 3-dimen...

A. Basu *, A. Sarkar and P. Basak

Department of Biochemistry, Gurudas College, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1921-28

1921-1928

767

258

25.

SYNTHESIS, EVALUATION AND POLYMORPHISM STUDIES OF NEW BENZIMIDAZOLE DERIVATIVES AS POTENT ANTIBACTERIAL AGENTS

Ten, 2-substituted benzimidazole derivatives were prepared and assessed against two Gram-positive bacteria (Streptococcus mutans, Staphylococcus aureus) and two Gram-negative bacteria (Psuedomonas aeruginosa, Escherichia coli). The derivatives were obtained by the condensation of 2-((1H-benzo[d] imidazol-2-yl) thio) acetohydrazide(4) with different substituted aromatic aldehydes and their structur...

K. L. S. Konyak, M. M. Maste, A. Saxena * and P. Inamdar

Department of Pharmaceutical Chemistry, KLE University College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1929-34

1929-1934

565

213

26.

TWEEN 80 ALTERS THE PRODUCTION RATIO OF PHARMACEUTICALLY IMPORTANT STEROID INTERMEDIATES, 4-AD AND ADD DURING BIOTRANSFORMATION OF SOY STEROL BY MYCOBACTERIUM SP. NRRL B-3805

4-androstene-3, 17-dione (4-AD) and androsta-1,4-diene-3,17-dione (ADD) are pharmaceutically important steroid intermediates produced by steroid biotransformation. Non-pathogenic mutants of saprophytic Mycobacterium have been used for production of 4-AD and ADD. Being an intracellular process, the substrate entry is the rate limiting step for 4-AD and ADD production. This biotransformation is also...

P. Awadhiya * and T. Banerjee

Applied Microbiology Laboratory, School of Life Sciences, Takshshila Campus, Devi Ahilya Vishwa-Vidyalaya, Khandwa Road, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1935-41

1935-1941

519

232

27.

EVALUATION OF RENAL EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF PORTULACA OLERACEA (WHOLE PLANT) IN ALLOXAN INDUCED DIABETIC RATS

Herbal plants are effective in the treatment of various diseases.  More or less they are unscientifically and improperly used. These plants deserve detailed studies in the light of modern medicine. Having  detailed  investigation  and  documentation   of herbal plants  used  in local   health traditions   and  after that doing  pharmacological  evaluation  of these  plants  and...

S. Shafi * and N. Tabassum

Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Kashmir, Jammu & Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1942-49

1942-1949

597

230

28.

HYDROCOTYLE SIBTHORPIODES EXTRACT LOADED IN CHITOSAN NANOCAPSULE AS AN EFFECTIVE ANTIBACTERIAL AGENT AGAINST FEW PREVALENT MICROBES IN WOUND

Hydrocotyle sibthorpiodes is a known medicinal plant and is used for treatment against many bacterial and fungal pathogens in a conventional application form. The present study was intended to enhance the activity of H. sibthorpiodes plant extract against four bacterial species in combination with clove oil and silver nanoparticles by preparing a chitosan based nanocapsule that cause chronicity in...

M. Garg * and P. J. Handique

Department of Biotechnology, Gauhati University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1950-55

1950-1955

525

211

29.

ANALGESIC ACTIVITY OF EXTRACTS OF EULOPHIA OCHREATA LINDL. AND ZINGIBER CASSUMUNAR ROXB. IN ANIMAL MODEL

The present study was designed to investigate Analgesic activity of Chloroform extract and isolate 1 of Eulophia ochreata Lindl. and dicholoromethanolic extract and isolate 2 of Zingiber cassumunar Roxb. The analgesic activity was assessed by using acetic acid induced writhing method and hot plate method. In acetic acid induced writhing method the extracts and isolates of both plants was administe...

A. A. Koparde * and C. S. Magdum

Department of Pharmaceutical Chemistry, KIMSDTU’s Krishna Institute of Pharmacy, Malkapur, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1956-62

1956-1962

554

217

30.

ACID NEUTRALIZATION CAPACITY AND COST EFFECTIVENESS OF ANTACID SUSPENSIONS SOLD ACROSS VARIOUS RETAIL PHARMACIES IN VIJAYAWADA

Antacids are the commonly prescribed drugs for treating gastroesophageal reflux disease (GERD). As these are manufactured and marketed by various multinational and local companies there is a need for evaluating the cost effectiveness and efficacy of these antacids as a matter of public concern. In the present study an attempt has been made to determine and compare the acid neutralization capacity ...

S. V. Rao * , B. Chamundeswari and K. Padmalatha

Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1963-68

1963-1968

588

339

31.

SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL ACTIVITY OF SOME NEW CHALCONES

In this work, an attempt was made to synthesize new chalcones by Claisen - Schmidt condensation of substituted benzaldehydes with 4-aminoacetanilide in the presence of base catalyst. The synthesized chalcone derivatives was characterized by FT-IR, 1H-NMR, and 13C-NMR and also tested for their antimicrobial activity and compared with the standard drugs....

M. Elavarasan, M. T. Thendral and S. S. Shafi *

Department of Chemistry, Thiruvalluvar University, Serkkadu, Vellore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1969-73

1969-1973

571

245

32.

CHARACTERIZATION AND STABILITY OF EXTRACELLULAR ALKALINE PROTEASES FROM HALOPHILIC AND ALKALIPHILIC BACTERIA ISOLATED FROM SALINE HABITAT OF LONAR SODA LAKE, INDIA

Culture dependent phenotypic characterization analyses were applied to study the protease producing bacteria from Indian Soda (Lonar crater). The uniqueness of the Lonar lake water is its salinity and alkalinity. A total of one hundred and fourteen bacterial cultures were isolated from the water and sediment samples collected from the hyper alkaline saline environment of Lonar lake. The thirty two...

V. M. Hemke and V. R. Dhundale *

New Arts Commerce and Science College, Ahmednagar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1974-79

1974-1979

590

299

33.

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF SALBUTAMOL AND BECLOMETHASONE IN BULK AND TABLET DOSAGE FORM

A new, simple, sensitive, precise, accurate and stability indicating RP-HPLC method has been developed for the simultaneous estimation of salbutamol and beclomethasone in combined tablet dosage form. The analysis was carried out at 230 nm and this chromatographic separation was achieved with Kromasil 250 C18 [250 x 4.6 mm, 5µ] column under 25 oC temperature and using mobile phase water and aceton...

N. Abbai * and S. A. Parameswari

Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupathi, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1980-88

1980-1988

641

254

34.

CYTOPROTECTIVE EFFECTS OF MORINDA CITRIFOLIA (NONI) ON CULTURED LENS EPITHELIAL CELLS

Oxidative stress is one of the factor that initiating development of cataract and describes the events leading to lens opacification, generally cataract is a clouding of the lens of the eye that will affect the vision either partially or completely. Proteins that are present in the lens begin to break down and the lens becomes cloudy. This will be avoided by taking external food supplements that a...

S. Konada *, S. Rentala, S. Dhurjeti and U. S. N. Murthy

Department of Biotechnology, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1989-93

1989-1993

1392

262

35.

PHYTOCHEMICAL INVESTIGATION AND SCREENING FOR INFLAMMATORY BOWEL DISEASE ACTIVITY OF ETHANOLIC EXTRACT OF TECTONA GRANDIS LINN. BARK

Inflammatory bowel disease (IBD) is a multifactorial process that causes ulcerative colitis and Crohn’s disease due to unknown mechanisms associated with release of proinflammatory mediators. Aim of the present study is to evaluate inhibitory activity by bark extract Tectona grandis Linn. (TGE) against experimental induced IBD. Two different models were used to induce IBD viz., Indomethacin-indu...

C. N. Balasaheb *, N. S. Annasaheb and K. Koumaravelou

Centre for Research and Development, PRIST University, Vallam, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1994-04

1994-2004

530

217

36.

GC-MS ANALYSIS OF BIOACTIVE COMPOUNDS FROM ETHANOLIC LEAF EXTRACT OF WALTHERIA INDICA LINN. AND THEIR PHARMACOLOGICAL ACTIVITIES

Bioactive compounds are the frontline potent agents in both nutraceutical and pharmaceutical industries. Recently, the bioactive compounds are gaining much importance for their ability in enhancing resistance to various diseases and to improve the health of people both by traditional and modern ways of administrations. Therefore, in the present investigation was undertaken to identify the compound...

P. Banakar* and M. Jayaraj

P. G. Department of Botany, Karnatak University, Dharwad, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2005-10

2005-2010

809

280

37.

PROGNOSTIC UTILITY OF LILLE SCORE IN ALCOHOLIC HEPATITIS

Background: Alcoholic liver disease is a spectrum of alcohol induced injury that includes fatty liver, alcoholic hepatitis and alcoholic cirrhosis. Corticosteroids are used in cases of severe alcoholic hepatitis with Maddrey’s Discriminant Function score > 32. However, many of the patients who are being managed by corticosteroids are non responders and mortality increases in such patients. Li...

D. Mishra, A. Prasad * and R. K. Jha

Department of Biochemistry, Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2011-18

2011-2018

1196

219

38.

COLON SPECIFIC DRUG DELIVERY OF LIQUISOLID PLUG OF SULFASALAZINE BY SINGLE CAPSULE WITH BILAYER COATING

The purpose of this study is to achieve colonic release of anti-inflammatory drug sulfasalazine used in the treatment of inflammatory bowel disease (IBD) to minimise side effects with a novel method of single capsule with bilayer coating. Sulfasalazine is an anti-inflammatory drug which acts topically on the inflamed colon to provide relief. In the present study a time and pH dependent colon targe...

S. Bhilegaonkar * and T. Palkar

Department of Pharmaceutics, P.E.S΄s Rajaram and Tarabai Bandekar College of Pharmacy Farmagudi, Ponda, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2019-26

2019-2026

663

262

39.

PREPARATION, CHARACTERIZATION AND EVALUATION OF TABLET FOR COLONIC DELIVERY

The aim of the present work is to develop and evaluate colon targeted drug delivery of satranidazole for an effective and safe therapy of amoebiasis. Amoebiasis is a parasitic disease caused by E. histolytica and it causes about 34 - 50 million symptomatic infections each year. The treatment of amoebiasis is effective with satranidazole. Therefore it was planned to develop a suitable dosage form, ...

P. M. Chavan * and S. Ughade

Department of Pharmaceutics, Shree Sainath College of Pharmacy, Dawalamethi, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2027-33

2027-2033

914

239

40.

LARVICIDAL ACTIVITY OF LEAF EXTRACT OF GINGER AND TURMERIC ON MOSQUITO LARVAE

Dengue fever is an important public health problem in tropical and sub-tropical Continent. Recently the number of severe forms of the disease, dengue hemorrhagic fever, and dengue shock syndrome are increased. Dengue virus, a arbo-virus responsible for dengue fever and spread through its vector, Aedes aegypti. Controlling the mosquito is the good strategy to prevent this disease. The traditional c...

K. Khanra, I. Choudhuri and N. Bhattacharyya*

Department of Biotechnology, Panskura Banamali College, Panskura R. S., Purba Medinipur, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2034-36

2034-2036

716

231

41.

MOLECULAR DOCKING STUDIES OF THE COMPOUNDS FROM PERGULARIA DAEMIA AND TERMINALIA CATAPPA L. LEAF EXTRACTS WITH CYP2E1,GST,UDP-GLUCURONYL TRANSFERASE AND Nrf2 BINDING SITE IN KEAP1, IL-6

Objective: Pergularia daemia and Terminalia catappa L.. Leaf extracted with hydroethanol and the extracts were separated by silica gel column chromatography. The selected column fractions are used in GC-MS analysis, from the GC-MS results eight phytochemical compounds are selected based on their biological activities. In the  present work we predict the interaction of the selected targeted protei...

V. Packirisamy and K. Vijayalakshmi *

Department of Biochemistry, Bharathi Women’s College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2037-47

2037-2047

670

293

42.

ANTICONVULSANT ACTIVITY OF AQUEOUS EXTRACT OF EUPATORIUM BIRMANICUM DC. LEAVES ON SEIZURE INDUCED BY PTZ IN ALBINO MICE, ALONE AND IN COMBINATION WITH ETHOSUXIMIDE

Objective: To evaluate the anticonvulsant activity of aqueous extract of Eupatorium birmanicum DC. leave (EB) alone and in combination with ethosuximide against seizure induced by PTZ in albino mice. Method: Aqueous extract of EB leaves was prepared using Soxhlet apparatus. The albino mice were fed with EB at 3 doses (200, 400 & 800 mg/kg). One hour after feeding, pentylenetetrazole (PTZ) was ...

L. Babycha and V. Valte *

Department of Pharmacology, Jawaharlal Nehru Institute of Medical Sciences, Imphal, Manipur, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2048-52

2048-2052

506

267

43.

THE IMPACT OF FOOT REFLEXOLOGY MASSAGE ON ANXIETY CAUSED BY BLOOD TRANSFUSION IN CHILDREN WITH THALASSEMIA

Introduction: Based on the results of formerly conducted studies, the application of invasive methods, such as blood transfusion, for the treatment of children with thalassemia cause distress and anxiety symptoms in these children; therefore, it is attempted to apply non-invasive, non-pharmacological, simple, and inexpensive nursing practice to improve these deficiencies. Thus, the present study w...

S. Dehghanmehr, G. Sheikh *, A. Siyasari, A. Sheikh, S. Nooraien and M. Salarzaei

Student Research Committee, Zabol University of Medical Sciences, Zabol, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(5).2053-57

2053-2057

652

231

44.

ANTIDIARRHEAL EFFECT OF STEM BARK OF CEIBA PENTANDRA GAERTN (BOMBA-CACEAE) IN RATS

This work aimed to evaluate the antidiarrheal effect of aqueous extract of steam barks of C. pentandra. Diarrhoea was induced by intragastric administration of castor oil. Intestinal transit was evaluated by using the charcoal method. The effect of the aqueous extract on muscarinics and α-adrenergic receptors was evaluated in atropine and yohimbine presence by using charcoal method. The results o...

R. D. G. Elion Itou *, A. W. Etou Ossibi, C. J. Morabandza, F. G. Nsondé Ntandou and A. A. Abena

Laboratoire de Biochimie et Pharmacologie, Faculté des Sciences de la Santé, Université Marien, Ngouabi, Brazzaville-Congo.

DOI: 10.13040/IJPSR.0975-8232.9(5).2058-61

2058-2061

503

193

45.

INVESTIGATING THE IMPACT OF SUGAR FREE GUM ON THE THIRST AND DRY MOUTH OF PATIENTS UNDERGOING HEMODIALYSIS

Introduction: Thirst and dry mouth are some of the most commonly observed symptoms in patients undergoing hemodialysis which can affect the quality of life of these patients. Finding uncomplicated, non-prescriptive solutions to reduce the dry mouth and irritation of these patients seems quite crucial. Since chewing sugar free gum is likely to alleviate these complications through increasing the fl...

S. Dehghanmehr, A. Sheikh*, A. Siyasari, M. H. Karimkoshteh, G. Sheikh, M. Salarzaei and S. Nooraien

Student Research Committee, Zabol University of Medical Sciences, Zabol, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(5).2062-66

2062-2066

700

216

46.

GAINING INSIGHT INTO PATIENTS MEDICATIONS AND THEIR SELF-REPORTED EXPERIENCE OF ADVERSE DRUG REACTIONS: A CROSS SECTIONAL STUDY IN THE EMERGENCY DEPARTMENT

Aim: To gain an insight into patients medications and their experience of self-reported adverse drug reactions. Methods: A cross sectional study was conducted in the Emergency Department of a teaching hospital in the Midlands, United Kingdom from February to March, 2012.The study included patients aged 16 or over and currently on treatment with one or more medications. All patients were questioned...

E. Cheema *, P. Sutcliffe and D. R. J. Singer

Clinical Pharmacy Department, College of Pharmacy, Umm - Al -Qurauniversity, Makkah, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.9(5).2067-72

2067-2072

889

287

47.

EVALUATION OF BIOACTIVITIES OF TWO POLYHERBAL FORMULATIONS FOUND IN SRI LANKAN AYURVEDIC TREATMENTS

Commercially available two polyherbal formulations (Chandra Kalka and Sharkaradi Kalka) were collected from local market. The objective of this study was to determine the Total Phenolic Content (TPC) , Total Flavonoid Content (TFC) of these two ‘Kalkas’ and to investigate the existence of antioxidant, anti-inflammatory, antibacterial and anti-tyrosinase activities. Total phenolic content and t...

A. M. R. Chamara, A. Kuganesan, K. D. Dolawatta, I. M. Amarathunga, W. Y. H. Wickramasinghe, Y. M. P. K. Madushani and G. Thiripuranathar*

College of Chemical Sciences, Institute of Chemistry Ceylon, Rajagiriya, Sri Lanka.

DOI: 10.13040/IJPSR.0975-8232.9(5).2073-79

2073-2079

677

226

48.

SOME CONNECTIVITY INDICES AND ZAGREB INDEX OF HONEYCOMB GRAPHS

In this paper, we investigate several topological indices in honeycomb graphs: Randić connectivity index, sum-connectivity index, atom-bond connectivity index, geometric-arithmetic index, First and Second Zagreb indices and Zagreb polynomials. Formulas for computing the above topological descriptors in honeycomb graphs are given....

Y. Gao, M. Imran, M. R. Farahani * and H. M. A. Siddiqui

Department of Applied Mathematics, Iran University of Science and Technology, (IUST) Narmak, Tehran, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(5).2080-87

2080-2087

517

185

49.

PATTERN AND PREVALANCE OF MENSTRUAL DISOREDERS IN ADOLESCENTS

Background: Menstrual disorders frequently affect the quality of life of adolescents and young adult girls and can be indicators of serious underlying problems. Objectives: Study aims to determine the prevalence and pattern of menstrual disorders in adolescents and their effect on everyday life. Design: A cross sectional study design was adapted. Settings: Government and private schools of Arifwal...

M. Zafar, S. Sadeeqa *, S. Latif and H. Afzal

Institute of Pharmacy, Lahore College for Women University, Lahore, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.9(5).2088-99

2088-2099

853

224

50.

EFFECT OF HUMIC AND SALICYLIC ACIDS ON OIL YIELD AND FLAVONOID GLYCOSIDE OF SAFFLOWERS (CARTHAMUS TINCTORIUS L.) AS MEDICINAL PLANTS GROWN IN IRAQ

This study was conducted to investigation the effect of humic acid and salicylic on oil yield and flavonoids glycoside of safflower plant (Carthamus tinctorius L.) grown in Iraq. After soil preparation the plant seeds were cultivated during winter growing seeds at 2015-2017 at Karbala region, South Baghdad in Iraq. The humic acid was applied at 1000, 2000 and 4000 mg/lit conception as organic flow...

A. Kashams *, M. A. Hamza and I. S. Abbas

College of Agriculture, Karbala University, Karbala, Iraq.

DOI: 10.13040/IJPSR.0975-8232.9(5).2100-04

2100-2104

529

222

51.

TRAINING NEED ASSESSMENT OF DISPENSING PHARMACISTS IN MAHARASHTRA

Background: A crucial part of Continuing Education is Training needs assessment (TNA). TNA assists in design and development of relevant educational courses and training modules, which are valuable for health care professionals to improve their knowledge and skills in accordance to latest developments in the field of clinical practices. Methods: A qualitative study was designed constituting Focuse...

S. B. Pawar * and A. P. Pawar

Department of Clinical Pharmacy, Poona College of Pharmacy, Bharati Vidyapeeth Deemed to be University, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2105-13

2105-2113

681

246

52.

PHARMACOKINETIC STUDY OF ANDROGRAPHIS PANICULATA ETHANOLIC EXTRACT TABLET

Andrographis paniculata (Burm. F) Nees, commonly known as the “king of bitters,” is an herbaceous plant belonging to the Acanthaceae and is found throughout tropical and subtropical Asia, Southeast Asia, and India. Andrographolide, a bitter diterpenoid, is the major active principle present in the plant. Authors have already worked on the phytochemical investigation, analgesic and antipyretic ...

S. A. Nitave ⃰ , N. B. Chougule and K. Koumaravelou

Centre for Research and Development, PRIST University, Vallam, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2114-19

2114-2119

572

246

53.

ANTI-NOCICEPTIVE ACTIVITY OF METHANOLIC FRACTION OF ETHANOLIC EXTRACT OF CROCUS SATIVUS STIGMAS IN MICE AND RATS

Background: Extensive use of analgesics like non-steroidal anti-inflammatory drugs, opioid is associated with undesirable side effects often limiting their use. Hence the search for indigenous safer analgesic agent is ongoing. It was considered worthwhile to evaluate analgesic activity of methanolic fraction of ethanolic extract of Crocus sativus (CSEEMF) stigmas. Objective: This study was conduct...

H. Dhar, S. R. More * and B. G. Balasaheb

Department of Pharmacology, B. J. Government Medical College, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2120-29

2120-2129

584

289

54.

PROTECTIVE ROLE OF GYMNEMIC ACID IN CURBING HIGH FAT DIET AND HIGH FRUCTOSE INDUCED PANCREATIC OXIDATIVE STRESS MEDIATED TYPE-2 DIABETES IN WISTAR RATS

High fat diet and High fructose intake is the predominant lifestyle change that increased the epidemic of type-2 diabetes. HFD+HF feeding leads to oxidative stress mediated T2D through production of free radicals and decrement of antioxidant enzymes. Our present study focussed on the curbing effect of gymnemic acid on high fat diet and high fructose feeding induced oxidative stress mediated Type 2...

L. N. Chakrapani and K. Periandavan *

Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).2130-39

2130-2139

641

202

55.

KNOWLEDGE, ATTITUDE AND PRACTICES REGARDING ANTIBIOTICS USE AMONG PARENTS FOR THEIR CHILDREN

Introduction: Antibiotics are used to perish the growth of bacteria. Undesirable use of antibiotics is presently common all over the world. Parent’s knowledge and attitudes towards antibiotics play a vital role in the success of treatment process. Due to lack of knowledge, sometimes antibiotics are badly used for the treatment of infection. Study aims to evaluate the knowledge, attitude and prac...

M. Atif, S. Sadeeqa *, H. Afzal and S. Latif

Institute of Pharmacy, Lahore College for Women University, Lahore, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.9(5).2140-48

2140-2148

716

200