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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 10 (2019) - Issue 2, February

Review Articles

 
Title
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1.

ELECTROSPUN NANOFIBERS AS ADVANCED ANTIBACTERIAL PLATFORMS: A REVIEW OF RECENT STUDIES

This study aimed to introduce antibacterial nanofibers, produced by electrospinning as a novel technique in constructing nanostructured materials. In the electrospinning technique, a high voltage is applied to a polymer solution to overcome the surface tension. A charged polymer jet is ejected to a grounded electrode. As the solvent is evaporated, the electrospun fiber with diameter from micromete...

M. A. Mohammadi, M. Rostami, S. Beikzadeh, M. Raeisi, M. Tabibiazar * and M. Yousefi *

Nutrition Research Center and Department of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI: 10.13040/IJPSR.0975-8232.10(2).463-73

463-473

1410

665

2.

HEALTH BENEFITS OF TENDER COCONUT WATER (TCW)

This review summarizes the health benefits of Tender Coconut Water (TCW). TCW is a natural, healthy, nutritious drink from coconut tree widely grown in tropical countries. Indonesia is the larger country with the largest coconut growing country in the world. The active compounds in TCW include methionine, L-arginine, cytokines, selenium, vitamin C, and Zn, Mn and Cu. L-arginine is present in TCW s...

S. T. Zulaikhah

Department of Public Health, Faculty of Medicine, UNISSULA, Semarang, Central Java, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(2).474-80

474-480

1521

403

3.

HIGH-DENSITY LIPOPROTEIN: ROLE IN REVERSE CHOLESTEROL TRANSPORT

High-density lipoprotein (HDL) mediates reverse cholesterol transport (RCT) through its potential to accept excess cholesterol from extrahepatic tissues, and delivers it to the liver for breakdown and excretion. HDL also has pleiotropic properties such as anti-apoptosis, anti-inflammation, and capacity to remove oxidized sterols and phospholipids from the circulation. HDL is composed of apolipopro...

D. M. Menge, N. K. Nair, T. P. Varghese and P. R. A. Vijayakumar *

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).481-88

481-488

688

312

4.

TARGETING THE ENZYME – THE NEW TOOL FOR DRUG DELIVERY

Enzymes are the protein molecule that acts as a catalyst for various biological reactions. The enzymes have a major role in designing the dose of the drug. Enzymes have a vital role as metabolizer of the xenobiotic. The activity or the mode of action of enzymes determines the bioavailability of drugs. The presystemic metabolism of the drug monitored by the gut wall and hepatic enzymes can...

D. Joseph * and S. R. Suseem

School of Advanced Sciences, Vellore Institute of Technology, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).489-93

489-493

748

267

5.

BIOACTIVITY OF SECONDARY METABOLITES OF VARIOUS PLANTS: A REVIEW

Plants are an important source for the discovery of new products of medicinal value for drug development and plants secondary metabolites are unique sources for pharmaceuticals food additives, flavors, and other industrial values. The commercial importance of these secondary metabolites has resulted in a great interest in its production and in exploring possibilities of enhancing its production us...

C. Jain *, S. Khatana and R. Vijayvergia

Department of Botany, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).494-04

494-504

1808

458

6.

ORPHAN DRUGS: OVERVIEW AND REGULATORY REVIEW PROCESS

Orphan drugs are medicines or vaccines intended to treat, prevent or diagnose a rare disease (viz., Huntington's disease, myoclonus disease, Tourette syndrome, etc.). The definition of rare diseases varies across jurisdictions but typically considers disease prevalence, severity, and existence of alternative therapeutic options. A rare disease is not universal and depends on the legislation and po...

Z. Thaker *, K. Jethva, D. Bhatt, M. Zaveri and S. Deshpande

Department of Regulatory Affairs, K. B. Institute of Pharmaceutical Education and Research, Sector - 23, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).505-18

505-518

802

211

7.

A REVIEW OF BREAST CANCER AND HORMONAL THERAPY

Breast cancer is a malignant tumor that develops from ductal and lobular cells of the breast. It is the most commonly occurring female cancer in the world. After cervical cancer, breast cancer is the second most common cancer in India. Several factors are known to affect the risk of breast cancer. There is mainly two types of breast cancer: ductal and lobular carcinoma. Estrogen, directly and indi...

B. Patel

Department of Pharmacology, Bhagwan Mahavir College of Pharmacy, Vesu, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).519-27

519-527

482

194

Research Articles

 
Title
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8.

HIGH FRUCTOSE INDUCED ADIPOGENESIS AND INHIBITORY POTENTIAL OF TRIGONELLINE ON MURINE MESENCHYMAL STEM CELLS: A MORPHOLOGICAL STUDY

Regular intake of carbohydrate diet containing high fructose or sucrose increases adipogenesis resulting in conditions like weight gain, high blood pressure, elevated blood glucose levels, insulin resistance, raised triglycerides, low HDL cholesterol, with metabolic syndrome as a leading consequence. Since intricacies of adipogenesis are of major relevance to human health; present study aimed to e...

N. Mahajan *, K. Raina and A. Gupta

Centre for Stem Cell, Tissue Engineering and Biomedical Excellence, Panjab University, Chandigarh, Chandigarh, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).528-36

528-536

634

289

9.

COMPARATIVE MOLECULAR DOCKING ANALYSIS OF FLAVONOID COMPONENT FROM LAUNAEA PROCUMBENS (ROXB.) AGAINST TYROSINE-PROTEIN KINASE FYN

Plants have been studied since ages for their therapeutic uses. In the earlier time, not much was known about the phytocompounds, but today the constituents of the different plants have been extracted and isolated for the use in the name of medicines or drugs. Flavonoid is one of the most characteristic classes’ of compounds in higher plants known to play several important roles including therap...

G. J. Mishra *, C. Prajapati, M. Patel and M. N. Reddy

Department of Biosciences, Bapalal Vaidya Botanical Research Centre, Veer Narmad South Gujarat University, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).537-45

537-545

977

257

10.

SIMVASTATIN LOADED NANO MIXED MICELLES: AN APPROACH TO TREAT HORMONE DEPENDENT CARCINOMAS

The main objective of the present research was to develop mixed micelles using two biocompatible copolymers, D-α-tocopheryl polyethylene-glycol 1000 succinate (TPGS) and poloxamer 188 (P188) to improve the aqueous solubility and targeting efficacy of Simvastatin (SMV) against a variety of hormone-dependent cancers. A solvent evaporation technique prepared the plain/single copolymer micelles (SCMs...

P. S. Kumbhar *, N. J. Patil, A. B. Patil, U. Sambamoorthy, J. I. Disouza and A. S. Manjappa

Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Panhala, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).546-54

546-554

680

337

11.

FORMULATION AND IN-VITRO EVALUATION OF METRONIDAZOLE LOADED HPMC K15M MUCOADHESIVE MICROCAPSULES FOR H. PYLORI INFECTION USING 32- FULL FACTORIAL DESIGNS

The purpose of the research was to develop and evaluate metronidazole loaded HPMC K15M mucoadhesive microcapsules for sustained drug release at the gastric mucosa. Metronidazole mucoadhesive microcapsules were formulated by ion gelation technique using 32 factorial designs. A 32 full factorial designs were used to derive a statistical equation, ANOVA analysis, contour plots, and 3D response surfac...

B. Paul, S. Adimoolam * and M. J. Qureshi

Department of Dosage Form Design, Faculty of Pharmacy, MAHSA University, Selangor, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.10(2).555-67

555-567

662

261

12.

PHYTOCHEMICAL EVALUATION AND HPTLC FINGERPRINT PROFILE OF CISSUS LATIFOLIA LAM. STEM

Cissus latifolia Lam. (Vitaceae) is a woody climber with leaf-opposed tendrils. It is a medicinal plant used in the traditional system of medicine for the treatment of various ailments. The present study focused on the identification and qualitative determination of phytoconstituent types and establishment of the HPTLC fingerprint profile of the hot and cold extracts of C. latifolia. Preliminary p...

J. Kuruvilla, R. S. Iyer and M. Anilkumar *

Department of Botany, Cell Culture Lab, Union Christian College, Aluva, Ernakulam, Kerala, India. DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.10(2).568-77

DOI: 10.13040/IJPSR.0975-8232.10(2).568-77

568-577

716

370

13.

SYNTHESIS OF PARACETAMOL-PEG PRODRUGS, IN-VITRO AND IN-VIVO EVALUATION

Paracetamol is a well-known drug for its antipyretic, analgesic and anti-inflammatory activity. The drug being an OTC had been used more frequently than required. As a result of this overdosage of the drug caused a hepatotoxic effect. So to overcome this, an approach of PEGylation was chosen. PEG 1500-Paracetamol, PEG 6000-Paracetamol, PEG 1500-Glycine-Paracetamol, and PEG 6000-Glycine- Paracetamo...

D. Kemisetti

Department of Pharmaceutical Chemistry, Vaagdevi Pharmacy College, Bollikunta, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).578-85

578-585

518

175

14.

TRANSDERMAL DELIVERY OF AZATHIOPRINE BY SOLID LIPID NANOPARTICLES: IN-VITRO AND EX-VIVO STUDIES

The aim of the present study was to prepare solid lipid nanoparticles (SLNs) of azathioprine to increase its permeability and to develop azathioprine loaded solid lipid nanoparticles (AZA SLNs) based transdermal film for topical administration with the aim of reducing systemic and gastro-intestinal side effects of the drug and achieve passive targeting of drug to the joint due to enhanced permeabi...

A. Syed and V. K. Devi

Department of Pharmaceutics, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).586-98

586-598

548

167

15.

DESIGN AND EVALUATION OF FAST DISSOLVING TABLETS OF ROFLUMILAST SOLID DISPERSIONS

The main objective of the present investigation was to formulate and evaluate fast dissolving tablets of Roflumilast solid dispersions using a direct compression method. Roflumilast solid dispersions were prepared by solvent evaporation as well as melting method. Roflumilast is a selective, long-acting inhibitor of the enzyme PDE-4 and has anti-inflammatory effects. It is used orally in the treatm...

S. A. Begum *, V. Madhuri and K. Padmalatha

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).599-11

599-611

851

186

16.

ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF COW URINE FROM MALNAD GIDDA – AN INDIGENOUS BREED

Aim of the study: The study was aimed to evaluate the antioxidant and anti-inflammatory activities of raw (ARCU) and distilled (ADCU) urine from an adult indigenous cow breed, Malnad gidda. Materials and Methods: Different radical scavenging models assessed antioxidant activity. Anti-inflammatory activity was assessed by carrageenan-induced rat paw edema method. The first group received saline and...

B. Rachana and K. S. Sreepada *

Department of Applied Zoology, Mangalore University, Mangalagangothri, Mangaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).612-18

612-618

624

215

17.

IN-VITRO AND IN-VIVO EFFICACY OF ROOT EXTRACT OF LAWSONIA INERMIS AGAINST INFLAMMATORY PARADIGM

The study was carried out to evaluate anti-inflammatory activity of alcoholic extract of roots of Lawsonia Inermis (LILAC). In-vitro anti-inflammatory activity was evaluated by Cyclooxygenase inhibitory assay wherein the LIALC showed a dose-dependent inhibition of both the enzymes with IC50 values of 58.2 μg/ml for COX-1 and 7.38 μg/ml for COX-2. In RBC membrane stabilization activity, LILAC at ...

E. N. Bharath, S. N. Manjula *, G. Bhavimani and K. Mruthunjaya

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).619-24

619-624

422

144

18.

PROTECTIVE EFFECTS OF ALLIUM SATIVUM EXTRACT AGAINST SODIUM FLUORIDE INDUCED NEUROTOXICITY

Fluoride becomes toxic at higher doses which leads to Fluorosis. In addition to dental and skeletal fluorosis, it also affects soft tissues including liver, heart, kidney, muscle, brain, etc. The aim of this study to examine the fluoride-induced oxidative stress and the protective role of Allium sativum ethanolic extract (ASEE) against underlying fluoride induced neurotoxic effects in the brain of...

S. Manusha, K. Sudhakar and K. P. Reddy *

Department of Zoology, University College of Science, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).625-33

625-633

379

168

19.

HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DRUG RELEASE OF LEDIPASVIR AND SOFOSBUVIR IN LEDIPASVIR AND SOFOSBUVIR TABLETS

Analytical scientists of the pharmaceutical industry aimed at developing robust HPLC methods for analysis of generic drug products. This paper deals with HPLC method of analysis for estimation of % drug release of Ledipasvir and Sofosbuvir in Ledipasvir and Sofosbuvir tablets used for the treatment of chronic hepatitis C virus (HCV) infection. For analysis of dual combination drug product, HPLC me...

R. Prasad *, S. Bhatt and K. Singh

Department of Chemistry, SRK University, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).634-41

634-641

706

166

20.

EVALUATION OF MUSCLE RELAXANT AND LOCOMOTOR ACTIVITIES OF MALPIGHIA EMARGINATA AND HOLOPTELIA INTEGRIFOLIA

The present study was designed to evaluate the muscle relaxant and locomotor activities of petroleum ether (PE), ethyl acetate (EA) and methanolic (MA) extracts of Malpighia emarginata (ME) and Holoptelia integrifolia (HI). The different concentrations were used to evaluate the toxicity in rats and revealed that they are nontoxic up to 2000 mg/kg. From the toxicity study, 200 and 400 mg/kg doses w...

V. Padmaja, M. C. Eshwaraiah and A. S. Nayak *

Department of Pharmaceutical Chemistry UCPSC, Satavahana University, Karimnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).642-48

642-648

453

134

21.

THE EFFECT OF SUBCHRONIC ADMINISTRATION OF ROSELLA (HIBISCUS SABDARIFFA L.) EXTRACT ON LEVELS OF UREUM, CREATININE, AND RENAL HISTOPATHOLOGY

Rosella (Hibiscus sabdariffa L.) calyx traditionally used to treat various diseases. There is limited evidence based could be found including the efficacy and safety. The present study was aimed to investigate the effects of subchronic administration of Rosella calyx extract on the renal function of female Sprague Dawley (SD) rats. The rosella calyx was extracted by 70% ethanol and evaporated with...

N. Mahfudh * and A. Fajrin

Faculty of Pharmacy, Universitas Ahmad Dahlan, Jl. Prof. Soepomo, Janturan, Yogyakarta, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(2).649-54

649-654

448

171

22.

A NOVEL STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ANTI-VIRAL CLASS OF ELBASVIR AND GRAZOPREVIR IN BULK AND PHARMACEUTICAL DOSAGE FORM

Objective: To develop accurate, precise stability indicating a method for simultaneous estimation of Elbasvir and Grazoprevir in bulk and pharmaceutical dosage form. Materials and Methods: Simple, rapid, precise, sensitive and reproducible validated stability-indicating Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method for the quantitative analysis of Elbasvir and Grazoprevir i...

P. V. Rao *, A. L. Rao and S. V. U. M Prasad

Department of Pharmaceutical Analysis, Vikas College of Pharmacy, Vissannapeta, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).655-60

655-660

378

135

23.

EVALUATION OF THE WOUND HEALING PROPERTIES OF MIMOSA PUDICA LINN. IN STREPTOZOTOCIN-INDUCED DIABETES MELLITUS IN RATS

Mimosa pudica Linn. (Fabaceae) It is traditionally used to treat wounds and diabetes mellitus. The study was designed to evaluate the wound healing properties of ethyl acetate and ethanolic extracts of seeds of Mimosa pudica in streptozotocin-induced diabetes mellitus in rats at dose levels of 100, 200 and 400 mg/kg body weight. Both extracts decrease the fasting blood glucose in a dose-dependent ...

P. Saini * and P. K. Verma

Department of Pharmacy, Government Polytechnic, Uttawar, Palwal, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).661-65

661-665

493

149

24.

MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEWLY SYNTHESIZED 1, 3, 4-THIADIAZOLE DERIVATIVE OF GUAR GUM

A new derivative of Guar gum, incorporated with 1, 3, 4-thiadiazole nucleus was synthesized by using a new green and efficient synthetic approach. Guar gum is a biodegradable polymer having numerous applications in various industries. Thiadiazole compounds are well known in the therapeutic world due to their pharmacological importance. The newly synthesized derivative was characterized by IR, H1 N...

A. Maheshwari * and S. Loonker

Department of Chemistry, Jai Narain Vyas University, Jodhpur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).666-71

666-671

352

167

25.

EFFECT OF MARINE BROWN ALGA LOBOPHORA VARIEGATA (J.V. LAMOUROUX) WOMERSLEY EX E. C. OLIVEIR VARIOUS SOLVENTS EXTRACTS ON DERMATOPHYTES

We here in the report the investigation of the antifungal activity of various solvent extracts obtained from a marine brown alga, Lobophora variegata against three fungal dermatophytes, namely Candida albicans, Candida tropicalis, Trichophyton mentagrophytes and a nondermatophyte Aspergillus flavus using disc diffusion method. Among the solvent extracts tested in the investigation, only the methan...

M. Subbiah, S. Thennarasan and S. Vajiravelu *

Post Graduate and Research Department of Chemistry, Pachaiyappa’s College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).672-77

672-677

415

147

26.

EVALUATION OF METHANOLIC EXTRACT OF CHYTRANTHUS MACROBOTRYS SEED (CMS) FOR ANTIMICROBIAL, α-GLUCOSIDASE AND α-AMYLASE INHIBITORY ACTIVITIES

Chytranthus macrobotrys (Sapindaceae) is one of the notable African medicinal plants with traditional history but lack scientific data. This report was aimed to evaluate C. macrobotrys seed (CMS) methanol extract for its phytochemical composition, antimicrobial activity, α-glucosidase, and α-amylase inhibitory activities. Methanolic extract of C. macrobotrys seed was investigated for its chemica...

F. J. Faleye *, C. B. Ajayi, O. A. Akinwumi and O. K. Popoola

Department of Chemistry, Ekiti State University, PMB 5363, Ado-Ekiti, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.10(2).678-85

678-685

503

131

27.

VALIDATION AND DEVELOPMENT OF TLC-DENSITOMETRY METHOD FOR STANDARDIZATION OF SOURSOP LEAF EXTRACT (ANNONA MURICATA LINN.) WITH QUERCETIN

Standardization is a process involving various chemical analysis methods based on pharmacological data involving general physical and microbiological analyzes aimed at the safety of a natural extract. To obtain the correct result, the standardization step is preceded by method validation. Quercetin can be obtained from the leaves of soursop (Annona muricata Linn.), which use for treatment fever, d...

Sudjarwo *, M. N. Alfi and F. Annuryanti

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(2).686-91

686-691

574

151

28.

SYNERGISTIC EFFECT OF AZADIRACHTA INDICA AND CURCUMA LONGA WITH FLUCONAZOLE GEL AGAINST CANDIDA ALBICANS

In this study, the synergistic effect of an extract of Azadirachta indica and Curcuma longa were investigated by the agar diffusion method. Different dilutions of the extract were prepared, and antifungal activity of the extracts of Azadirachta indica and Curcuma longa against Candida albicans was measured alone and in combination with fluconazole gel. The zone of inhibition of Azadirachta indica...

A. Saini, G. Saini, B. Singh *, M. Vyas, S. Verma and O. Prakash

Department of Quality Assurance, Abhilashi College of Pharmacy, Mandi, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).692-00

692-700

422

139

29.

DESIGN, SYNTHESIS, DOCKING STUDY AND PHARMACOLOGICAL EVALUATION OF NOVEL -2- (5-(1H-INDOL-3-YL)- 1, 3, 4-THIADIAZOL -2 -YLIMINO) -5 -(SUBSTITUTED BENZYLIDENE) THIAZOLIDIN-4-ONE ANALOGUES

A series of novel analogues of 2-(5-(1H-indol-3-yl)-1, 3, 4-thiadiazol-2-ylimino)- 5- (substituted benzylidene)thiazolidine-4-one have been synthesized. The structures of newly synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR and Mass spectroscopy. The synthesized compounds showed significant antibacterial activity against gram-positive bacteria: Staphylococcus aureus (MTCC 3160), Ba...

P. Taya, D. K. Mehta * and R. Das

Department of Pharmaceutical Chemistry, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).701-11

701-711

451

176

30.

PHYTOCHEMICAL AND ANTIMICROBIAL POTENTIAL OF SEED AND BARK EXTRACTS OF SWIETENIA MAHAGONI (L.) JACQ.

Swietenia mahagoni (L.) Jacq. belongs to the Meliaceae family and it is native to the West Indies. It was introduced to India in 1975 and now grown in any parts of India. Biological activities of the plant are due to the abundance of phenolic compounds including different terpenoids and limonoids. The plant possesses various secondary metabolites which are responsible for its anti-bacterial, anti-...

P. Yasotha *, K. Sangeetha and R. Rajendran

Department of Costume Design and Fashion, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).712-20

712-720

513

188

31.

STUDY ON THE ANTI METASTATIC AND ANTICANCER ACTIVITY OF TRITERPENE COMPOUND LUPEOL IN HUMAN LUNG CANCER

Lup-20(29)-en-3-ol, known as Lupeol is one of the most extensively studied triterpene compounds for their diverse biological properties. Natural triterpenoids gain pre-eminence in cancer research owing to their effects in regulating transcription factors and pathways associated with cell proliferation. The objective of the present study was to evaluate the anticancer activity of Lupeol on human ad...

T. S. Babu, B. P. Michael, C. Jerard, N. Vijayakumar and R. Ramachandran *

Biogenix Research Center for Molecular Biology and Applied Sciences, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).721-27

721-727

495

155

32.

METHOD DEVELOPMENT, VALIDATION AND STABILITY INDICATING ASSAY FOR TENELIGLIPTIN HYDROBROMIDE BY RP-UFLC

The study aimed to develop a specific, exact, selective, precise and accurate Reversed Phase Stability Indicating Ultra-fast Liquid Chromatography (RP-UFLC) strategy is created and validated for Teneligliptin hydrobromide in the pure and marketed formulation. The method showed an adequate separation for Teneligliptin hydrobromide from their degradation products. The chromatographic separation was ...

R. Maruthi *, R. S. Chandan and A. K. Tengli

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).728-35

728-735

505

159

33.

ANTICOCCIDIAL AND ANTIOXIDANT ACTIVITY OF GASTRO’IMMUNE -POLYHERBAL FORMULATION ON COCCI OOCYSTS INFECTED MICE JEJUNUM

Herbal drugs are prescribed widely as an anti-coccidial agent even when their biologically active compounds are unknown, because of their effectiveness, lesser side effects, and relatively low cost. So, in the current study, a poly-herbal formulation was used to find out its effect as an anti-coccidial effect. In the present study, the parameters evaluated were the WBC count, Glutathione levels, m...

S. Ghosh, R. Sinharay, N. Bangodi, K. P. S. Gowda *, N. Loganayaki, S. Kumar and K. Venkateswarlu

Department of Pharmacology, PES College of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).736-41

736-741

412

151

34.

ROLE OF CD4+T CELL SUBSETS IN THE DETERMINATION OF THE CLINICAL OUTCOME OF JAPANESE ENCEPHALITIS INFECTION

Japanese encephalitis is the most common arthropod-borne human encephalitis in the world. JEV clinical outcomes vary from complete recovery to recovery with neuropsychiatric sequelae to death. Contribution of T cells to the control and immunopathology of JEV infection has been reported in various studies. CD4+ T cells were found to be major T cells that has role in protection as well as affecting ...

A. Zia, M. K. Rai, V. Agarwal and T. N. Dhole *

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).742-46

742-746

334

146

35.

A STUDY ON PHYTOCHEMICAL COMPOSITION, GC-MS ANALYSIS AND ANTI-MICROBIAL POTENTIAL OF METHANOLIC LEAF EXTRACT OF ALSTONIA SCHOLARIS (L.) R. BR.

The present study was carried out to assess the various phytochemical composition, GC-MS analysis, and antimicrobial potential of methanolic leaf extract of Alstonia scholaris (L.) R. Br. by using different solvents. Phytochemical analysis revealed the presence of alkaloids, coumarins, flavonoids, glycosides, phenols, quinines, saponins, tannins, steroids and terpenoids. Susceptibility testing by ...

N. T. Swamy, G. Rosaiah *, K. Babu and K. V. Kumar

Department of Botany and Microbiology, Acharya Nagarjuna University Nagarjunanagar, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).747-55

747-755

608

196

36.

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF NEBIVOLOL AND VALSARTAN IN BULK AND DOSAGE FORM

The several spectrophotometric and HPLC methods have been reported for determination of Nebivolol and Valsartan individually or in combination with other drugs in pharmaceutical dosage forms. Hence, in the present study, a new, sensitive, suitable and cost-effective Reversed-Phase High-Performance Liquid Chromatography method was developed and validated for the determination of Nebivolol and Valsa...

P. B. Jadhav * and C. D. Parwe

Department of Pharmaceutical Chemistry, S. N. D. College of Pharmacy, Yeola, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).756-62

756-762

646

185

37.

NON ENZYMATIC AND ENZYMATIC ANTIOXIDANT STATUS OF WISTAR RAT ERYTHROCYTE AFTER DIETARY ZINC DEFICIENCY

Zinc deficiency is prevalent worldwide. The present study deals with the effect of dietary zinc deficiency on erythrocytes of Wistar rats. Male Wistar rats (40-50 g) were divided into 3 groups: control (ZC) fed 100 μg/g zinc; pair fed (PF) fed 100 μg/g zinc but the diet given was based on the diet consumed the previous day and zinc deficient (ZD) fed 1 μg/g zinc. The experiment was carried out ...

N. Nair *, S. Bedwal, P. Sharma, A. Saini, D. Kumari and R. S. Bedwal

Department of Zoology, Cell and Molecular Biology Laboratory, Centre for Advanced Studies University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).763-68

763-768

341

151

38.

PRESCRIPTION KNOWLEDGE AMONG PATIENTS WITH CARDIOVASCULAR DISEASES AT THE MOI TEACHING AND REFERRAL HOSPITAL, KENYA

Cardiovascular diseases (CVDs) cause 30% of deaths globally and are reported to be on the increase in sub-Saharan Africa. Medications prescribed for a CVD require a lifetime commitment. As a result patient must adhere to prescribed medication. However, prescription adherence is influenced to a large part by prescription knowledge. Although disease outcome is influenced by prescription knowledge, e...

P. Olesikamoi, P. O. Onyango* and W. Odero

School of Physical and Biological Sciences, Maseno University, Private Bag, Maseno, Kenya.

DOI: 10.13040/IJPSR.0975-8232.10(2).769-74

769-774

355

164

39.

DESIGN AND IN-VIVO EVALUATION OF TOPICALLY APPLIED CHLORPHENIRAMINE MALEATE GELS

This study was aimed at formulating topically applied Chlorpheniramine maleate gel (CPM gel). Combined effects of propylene glycol and polyethylene glycol as permeation enhancers were investigated using response surface methodology. The formulated gels were characterized for various formulation attributes including viscosity, homogeneity, pH, spreadability and accelerated stability studies (40 ± ...

S. N. H. Shah, H. Javed *, M. Nisar and A. Nawaz

Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.10(2).775-82

775-782

489

128

40.

STANDARDIZATION OF SIDDHA POLYHERBAL FORMULATION PANCHABAKIYA CHOORANAM THROUGH ICPOES AND FTIR TECHNIQUES

Siddha system of medicine is a traditional medicinal system being followed mainly in South India. It is better known as one among the AYUSH medicinal system. The present study aims to standardize the Siddha poly-herbal formulation Panchabakiya chooranam (PBC), which is mentioned in the Siddha classical text Anuboga vaidya Brahma ragasyam indicated for stomach burn, burning sensation in anus and di...

V. Indumathy *, B. Anbarasan, N. Anbu and K. Kanakavalli

Department of Maruthuvam, Government Siddha Medical College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).783-85

783-785

397

144

41.

GCMS AND ELEMENTAL ANALYSIS OF MADHUCA LONGIFOLIA VAR. LATIFOLIA SEEDS

Madhuca longifolia var. latifolia belonging to the family Sapotaceae which was also known as Mahua and Butter tree. The present study was designed to identify the fatty acids present in oil and to analyze the elements present within the seed and seed cake. After extraction of oil, it was found that the seeds were high in oil content within the kernel. The oil percentage found in seed was highest r...

Y. C. Suryawanshi and D. N. Mokat *

Department of Botany, Savitribai Phule Pune University, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).786-89

786-789

472

148

42.

COMPARATIVE ANALYSIS OF SOCIO-ECONOMIC STATUS IN RHD PATIENTS: A TERTIARY CARE INTERPRETATION AND EXPLORING REASONS TO IMPROVE ADHERENCE

Rheumatic heart disease (RHD) is a major burden in developing countries and leads to heart valve damage resulting from acute rheumatic fever (ARF). RHD and its complications cause more than 1.4 million deaths per year, globally. The mortality in RHD depends on the factors related to socio-economic status and tertiary care, especially in developing countries like India. In this study, a comparative...

K. Bansal *, S. K. Rajput, V. Sharma and V. S. Mathur

Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).790-94

790-794

392

149

43.

THE EFFECT ON CELL VIABILITY AND REDUCTION OF CORTISOL ACTIVITY BY AQUEOUS EXTRACTS OF GREEN COFFEE BEAN

A recent surge of lifestyle disorders such as obesity, Type II Diabetes Mellitus and cardiovascular diseases, has led to a search of dietary changes that could be adopted into the daily lifestyle to prevent these lifestyle disorders. A nutraceutical is an upcoming option that has garnered a lot of attention and has warranted a lot of research. Green coffee beans are unroasted coffee beans which ha...

K. G. Singh *, S. A. Lad and B. D. Khawas

Department of Chemistry, Mount Carmel College, Palace Road, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).795-01

795-801

400

152

44.

BIOMOLECULAR PROTECTIVE EFFECT OF THE METHANOLIC EXTRACT OF THE FLOWERS OF CAESALPINIA PULCHERRIMA, SWARTZ. AGAINST OXIDATIVE DAMAGE

Free radicals and reactive oxygen species (ROS) production above basal levels cause irreversible damage to the cell membrane, DNA and other cellular structures by oxidizing lipids, proteins and nucleic acids resulting in dysfunction of biomolecules within cells and, finally, cell death. These free radical-induced reactions are ascertained to play multiple roles in degenerative or pathological even...

S. T. Yamuna and P. R. Padma *

Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women University, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).802-10

802-810

404

147

45.

PREFORMULATION STUDY OF PIROXICAM

Preformulation testing is the first step in the rational development of dosage forms of a drug substance. The preformulation investigations confirm that there are no significant barriers to the compound’s development as a marketed drug. The formulation scientist uses this information to develop an efficacious, stable and safe dosage form. The main objective of the present research work was to do...

A. A. Bachhav *, S. A. Ahire and A. G. Jadhav

Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).811-18

811-818

725

216

46.

STUDY THE ANTIBIOTIC RESISTANCE PATTERN IN A TERTIARY CARE TEACHING HOSPITAL

Introduction: Antibiotics suppress the growth of or kill another microorganism at very low concentrations. Therefore this is the one of the supreme invention need of this era. Most bacteria are becoming resistant to various antibiotics, make a limitation for treating minor and major infectious. Hence, determining the resistance patterns in the geographical area will help in choosing and use of the...

K. V. Ramanath *, P. Biswas, R. Sunny and S. John

SAC College of Pharmacy, Adichunchangiri University, B. G. Nagar, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2). 819-29

819-829

511

173

47.

INDUCTION OF ROOTS AND IN-VITRO REGENERATION OF NOTHAPODYTES NIMMONIANA GRAHAM FROM EMBRYO CULTURES

The present study was aimed to develop the effective protocol for induction roots and in-vitro regenerated plants from embryo culture of Nothapodytes nimmoniana. Excised embryos were sterilized under the aseptic condition and cultured on L2 medium fortified with different concentration (0.5 - 3 mg/L) and the combination of auxins and cytokinins. Maximum shoot initiation was observed in BAP (2 mg/L...

H. R. Raveesha * and D. R. Vasudha

Department of Botany, Jnanabharathi Campus, Bangalore University, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).830-35

830-835

390

143

48.

COMPARATIVE STUDIES ON BIOCHEMICAL, HISTOPATHOLOGICAL AND FTIR-ATR SPECTRAL STUDIES OF HYPERLIPIDEMIA INDUCED BY CHOLESTEROL-RICH DIET IN RATS

Objective: To compare the routine biochemical and histological techniques with FTIR-ATR spectroscopic methods in diagnosing hyperlipidemia. Materials: Compositional changes in the serum and tissues reflects the healthy and pathological status of animals. FTIR-ATR was attempted as an additional tool for evaluating the composition in the serum as well as in tissues materials. To achieve this Wistar ...

S. Khatheeja *, A. Safiullah, M. Alsawalha, A. R. Prabhakaran, V. P. Veeraraghavan and S. K. Mohan

Department of Physics, Justice Basheer Ahmed Sayeed College for Women, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).836-45

836-845

505

196

49.

PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIOXIDANT, ANTI-MICROBIAL AND ANTI-INFLAMMATORY ACTIVITY OF “CURCUMA CAESIA”

The rhizomes of Curcuma caesia Roxb. (Zingiberaceae) Are traditionally used in the treatment of various ailments and metabolic disorders like leucoderma, asthma, tumors, piles, bronchitis, etc. in Indian system of medicine. Considering the importance of natural products in modern phytomedicine, the antioxidant and ant mutagenic activities of C. caesia Roxb. rhizome extract and its fractions were e...

V. Kalita *, P. Pegu and P. Chetia

Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Hatkhowapara, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).846-55

846-855

453

211

50.

A COMPARISON OF MENTAL HEALTH, QUALITY OF LIFE, AND HAPPINESS IN MOTHERS OF CHILDREN WITH AUTISM SPECTRUM DISORDERS VERSUS MOTHERS WITH HEALTHY CHILDREN

Introduction: Autism spectrum disorders (ASD) are a group of mental problems that interfere with social interaction skills, and behavioral spectrum. ASDs are one of the most prevalent developmental disorders among children. The purpose of this study was to examine the mental health, quality of life, and happiness in mothers who had ASDs children and compare them with mothers having healthy childre...

M. Kousha, R. Soleimani *, M. F. K.Masjedi, S. Hoshyarfard and A. Yhayazadeh

Department of Psychiatry, Kavosh Cognitive Behaviour Sciences and Addiction Research Center, Shafa Hospital, School of medicine, Guilan University of Medical Sciences, Rasht, Iran.

DOI: 10.13040/IJPSR.0975-8232.10(2).856-62

856-862

489

254

51.

THE EFFECT OF PSYCHIATRIC EDUCATION ON THE ATTITUDE OF MEDICAL STUDENTS OF GUILAN UNIVERSITY OF MEDICAL SCIENCES TOWARD PSYCHIATRY

Introduction: While many medical students have a special talent in psychiatry, attracting them to this specialty is a problem. The purpose of this study was to examine the impact of psychiatric education on the attitude of medical students on psychiatric patients. Method: In this observational study, 200 medical externs and interns were recruited. Before and after attending the 4-week psychiatry e...

J. M. Mohammad, S. Robabeh * and A. Y. Mahdi

Department of Psychiatry, Kavosh Behavioral Cognitive and Addiction Research Center, Shafa Hospital, Guilan University of Medical Sciences, Rasht, Iran.

DOI: 10.13040/IJPSR.0975-8232.10(2).863-68

863-868

358

167

52.

NATURAL ALTERNATIVES TO TREAT CANCER: A STUDY ON ANTICANCER ACTIVITY OF LAWSONIA INERMIS LINN.

Henna (Lawsonia inermis) is widely used cosmetically and medicinally. Literature survey reveals that the plant henna also has anticancer activity. Most of the anticancer activities of Lawsonia inermis plant are carried out using total leaves extract, and purified individual compounds also. The cytotoxicity profile of the extracts, as well as purified fractions, was determined by MTT assay on HeLa ...

A. N. Mungle *, A. M. Ittadwar and D. N. Begde

Gurunanak College of Pharmacy, Kamgar Nagar, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).869-74

869-874

409

161

53.

SYNTHESIS AND CHARACTERIZATION OF PVA BASED SERICIN FILM FOR ANTIBACTERIAL WOUND DRESSING

Sericin is a globular protein obtained from degumming of silk cocoon in the silk reeling process. The sericin film was synthesized for the application of antibacterial wound dressing, but it has a low physical property, hence the synthetic polymer was used in the synthesis of highly stable biocompatible film. The PVA based sericin film was prepared by solvent casting method by the addition of synt...

M. Abirami *, S. Shree Shayanthi and R. Rajendran

PG and Research Department of Microbiology, PSG College of Arts & Science, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).875-80

875-880

461

138

54.

EVALUATION OF THE CHARACTERISTICS OF DIABETES INDUCED BY THE ADMINISTRATION OF ALLOXAN TO FRUCTOSE FED WISTAR RAT

Several type II diabetic models have been developed to evaluate the effects of potential antidiabetic agents. However, there seems to be a paucity of literature evaluating the characteristics of diabetes-induced with fructose and alloxan. Therefore, this study was conducted to characterize fructose-alloxan diabetes. Thirty rats were grouped equally into Control, Fructose and Fructose plus 150 mg/k...

T. D. Fabiyi-Edebor * and A. A. Fasanmade

Department of Physiology, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.10(2).881-89

881-889

452

181

55.

CHEMICAL PROFILING, ADME PREDICTION OF BOERHAVIA DIFFUSA LINN. AND CRATEVA NURVALA BUCH. HAM IN THE MANAGEMENT OF UROLITHIASIS

Background: This study was carried out to investigate qualitative and quantitative phytochemical analysis and free radical scavenging activity of Boerhavia diffusa (root) and Crateva nurvala (bark) along with certain computational ADME (Absorption, Distribution, Metabolism, Excretion) parameters of compounds analyzed from Boerhavia diffusa (root) and Crateva nurvala (bark). Methods: The dried powd...

S. R. Gophane * and C. N. Khobragade

School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).890-16

890-916

422

148

56.

FORMULATION AND EVALUATION OF RAMIPRIL LIQUISOLID COMPACT USING NOVEL CARRIER

The aim of the present investigation was to enhance the dissolution of poorly water-soluble drug Ramipril (BCS - II) drug through Liquisolid compact. The liquisolid compacts were prepared with a varied quantity of liquid and powder ingredients using microcrystalline cellulose as a carrier, Aerosil 200 as a coating material, polyethylene glycol 400, propylene glycol and tween-80 as liquid vehicles,...

V. K. Suryawanshi *, B. Gidwani, A. Verma, N. Dubey and C. D. Kaur

Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).917-25

917-925

563

151

57.

THE EFFECT OF INTAKE DUCK EGG YOLK ON BODY WEIGHT, LIPIDS PROFILE AND ATHEROSCLEROSIS DISEASES IN MALE WISTAR RATS

Duck egg yolks contained fat and higher cholesterol than chicken eggs. A high-fat diet has caused obesity to impact for the development of diseases such as type II diabetes, stroke, atherosclerosis, hypertension, cardiovascular disease and certain forms of cancer. The purpose of using laboratory animals determined the effects of duck egg yolk to body weight, lipids profile, and atherosclerosis dis...

N. W. Bogoriani *, A. A. B. Putra and W. E. Heltyani

Department of Biochemistry, Faculty of Mathematic and Natural Science, University of Udayana, Bali, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(2).926-32

926-932

473

160

58.

NUTRITIONAL STATUS OF CHILDREN WITH CONGENITAL HEART DISEASE

Congenital heart disease (CHD) is a defect in the heart or major blood vessels that are present in children at birth & CHD it occurs in approximately 1% of live births in developed countries. Infants and children with CHD exhibit a range of delays in weight gain and growth. Objective: To find out the relationship between the children with CHD nutritional status and their socio-demographic char...

O. F. Washeel * and E. G. A. Ma'ala

Department of Pediatrics Health, Nursing College, Al-Muthanna University, Samawah, Iraq.

DOI: 10.13040/IJPSR.0975-8232.10(2).933-38

933-938

381

168

59.

SYNTHESIS AND CHARACTERIZATION OF GRAPHENE-USNIC ACID CONJUGATE MICROSPHERES AND ITS ANTIBACTERIAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS

In response to the spacious propagation of bacterial contamination stimulated by pathogens, the evolution of novel therapeutics with eminent antibacterial action is of avid concern. When the skin unity is ruptured accidentally or intentionally, its natural defenses will thus be vitiated, and topical medication may be prescribed. Topical medicaments are designed to either obliterate or inhibit the ...

S. Pandey *, S. K. Misra and N. Sharma

Mahatma Gandhi Institute of Pharmacy 1, Junabganj, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).939-46

939-946

435

156

60.

ANTI-OSTEOPOROTIC ACTIVITY OF CUCURBITA PEPO AND LOW LEVEL LASER BEAM ON GLUCOCORTICOID INDUCED OSTEOPOROSIS IN RATS

Objective: The main aim of the present study is to investigate the activity of the anti-osteoporotic activity of Cucurbita pepo seed powder (CPSP) and low level laser beam (LLLT) on glucocorticoid induced osteoporosis in rat model. Materials and Methods: Animals were randomly divided into six groups containing six rats each (n=6). Group I normal control, Group II dexamethasone induced osteoporotic...

G. Sindhura and K. P. S. Gowda *

Department of Pharmacology, PES College of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).947-59

947-959

191

67

61.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL COUMARIN ANALOGUES

The desired target Compounds (4a-e), (5a-e) and (6a-e) were prepared in two steps. Reaction of 3-acetyl-6-bromo-2H-chromen-2-one (1) with 3-(Aryl)-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-e) in presence of aqueous KOH solution and the reaction mixture stirred  for 2 hours and then filtered, furnished the desired 6-bromo-3-((E)-3-(3-(Aryl)-1-phenyl- 1H-pyrazole-4-yl) acryloyl)- 2H-chromen-2- ones ...

S. B. Patil * and N. M. Goudgaon

Department of Chemistry, Ramaiah Institute of Technology, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).960-65

960-965

373

141

62.

ANTI-INFLAMMATORY AND ANTIHYPERCHOLESTEROLEMIC ACTIVITY OF ROSA CENTIFOLIA, CORIANDRUM SATIVUM AND CYNODON DACTYLON

Hypercholesterolemia is one of the major conditions that are prevalent in today’s world, the significant causes being unhealthy food habits and lifestyle or abnormal genetic conditions. HMG CoA reductase is an important rate-limiting enzyme in the mevalonate pathway that synthesizes cholesterol. Biosynthesis of cholesterol in the liver can be reduced significantly by inhibiting HMG CoA reductase...

A. Thilagavathy *, S. Dsouza, A. Shriraksha and K. G. Singh

Department of Biochemistry, Mount Carmel College, Autonomous, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).966-72

966-972

524

183