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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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23.

ADVERSE DRUG INTERACTIONS IN ELDERLY HOSPITALIZED PATIENTS: A PROSPECTIVE ANALYSIS

Objective: To determine the incidence, characteristics, predictors and cost associated with the management of adverse drug interactions (ADIs) in elderly population. Methods: The prospective, intensive and interventional study included all patients taking at least two medications who were elderly admitted to medicine or surgery wards of a tertiary care hospital and were followed untill discharge. ...

A. S. George, M. Ramesh* and J. Sebastian

Department of Pharmacy Practice, JSS College of Pharmacy, Jagadguru Sri Shivarathreeshwara University, Sri Shivarathreeshwara Nagar, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1913-20

1913-1920

3533

1464

35.

EVALUATION OF MELATONIN AND COENZYME Q10 FOR GASTROPROTECTIVE EFFECT IN ASPIRIN AND IBUPROFEN INDUCED GASTRIC ULCERS IN RATS

The present study was carried out to evaluate the gastroprotective effect of melatonin, coenzyme Q10 (CoQ10) and its combinations with rabeprazole in aspirin (400 mg/kg) and ibuprofen (300 mg/kg) induced gastric ulcers in albino Wistar rats. In aspirin-induced gastric ulcer model, the treatment of melatonin (20 mg/kg), CoQ10 (100 mg/kg) and rabeprazole (20 mg/kg) for 10 days significantly reduced ...

P. Kulkarni, G. Bhavimani, A. Javalgikar and N. Mahurkar *

Department of Pharmacology, HKES MTRIPS, Kalaburagi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1802-07

1802-1807

3533

1608

14.

MOLECULAR DOCKING AND ADMET STUDIES OF BIOACTIVE COMPOUNDS OF RHIZOPORA MUCORNATA AGAINST BACTERIAL ENZYME PROTEIN TYROSINE PHOSPHATASE

Objective: The bioactive compounds of Rhizopora mucornata were docked against the bacterial enzyme protein tyrosine phosphatase to determine the potential inhibition. In this research the molecular docking analysis of drug compounds with virulent protein was studied. Material and Methods: Protein Tyrosine phosphatase is an enzyme that is being present in staphylococcus infection that plays an impo...

R. A. Biswal, A. Sharma, A. Aishwariya and V. Pazhamalai *

Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1635-42

1635-1642

3532

1389

67.

HETEROLEPTIC MONONUCLEAR RUTHENIUM(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES

Mononuclear ruthenium(II) complexes of the type [Ru(bpy)2(L)] (PF6)2, where L=4,5-bis(4-dimethyaminophenyl)-1H, 1 'H-2,2'-biimidazole (1) and 4,5-bis (4-fluorophenyl) - 1H, 1' H-2,2'-biimidazole (2) have been synthesized and characterized by elemental analyses and  spectroscopic techniques such as UV-visible, IR and ESI-MS. The redox behavior of the complexes has been studied by cyclic and differ...

M. Kiruthika and P. Dharmalingam *

Department of Chemistry, Urumu Dhanalakshmi College, Tiruchirappalli, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(3).1485-91

1485-1491

3530

1623

44.

CHARACTERIZATION AND QUANTIFICATION OF ETHYLHEXYLGLYCERIN

Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethyl hexyl group is bound to glycerin at one end by an ether linkage. it has been used as a common ingredient in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. The compound is synthesized by esterfication of 2-Ethylhexanol and epichlorohydrin,...

R. Arla *, J. S. Rao and K. Koumaravelou

Department of Pharmacy, Prist University, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3474-79

3474-3479

3530

1928

65.

THE SYNTHESIS OF QUINAZOLON-1,3,4-OXADIAZOLE ANALOGUES AND STUDIES OF THEIR ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY

A series of conjugation of two heterocycles 1, 3, 4-oxadiazole and quinazolone were synthesized and screened for antimicrobial as well as antioxidant activity. Compound4-(4-oxo-2-phenyl-quinazoline-3(4H)-yl)-benzohydrazide 3 on cyclization with different aromatic acids in the presence of phosphoryl chloride (POCl3) give different 1, 3, 4-oxadiazole derivatives. Similarly, compound 3 on reaction wi...

V. S. Kulkarni *, D. S. Chavan and G. P. S. Kumar

Department of Pharmaceutical Chemistry, Indira Institute of Pharmacy, Sadavali (Devrukh), Ratnagiri, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1477-84

1477-1484

3529

1959

9.

AN OPTIMIZED SYNTHETIC PROTOCOL FOR BIOLOGICALLY RELEVANT, HIGHLY FUNCTIONALIZED BENZOFURANS

We report here the optimization of an oxidative Michael addition protocol for the synthesis of highly functionalized, biologically relevant benzofurans on gram scale. Rigorous screening of reaction conditions including solvent, atmosphere, base and incubation time, and development of a straight forward precipitation step afforded benzofurans in greater than 95% purity for direct use in biological ...

Preetpal Singh Sidhu

Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23219, United States of America

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(1).83-88

83-88

3528

1971

78.

COMPLEXES OF COBALT(II), NICKEL(II) AND ZINC(II) WITH SCHIFF BASES DERIVED FROM 4-ANISALDEHYDE

A new spectrophotometric method is developed for the determination of artesunate (ARTS) in pharmaceutical preparation and bulk drug. The method involved heat-catalyzed derivatization of the drug with acetic anhydride and concentrated sulphuric acid producing a yellow coloured product peaking at 420.6 nm. The optimum conditions of the reaction and the analytical procedures of the assay were establi...

S. Meena and S. M. Sandhya*

Department of Pharmaceutical Analysis, Devaki Amma Memorial College of Pharmacy, Pulliparamba P.O, Malappuram – 673634, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(12).5111-15

5111-5115

3528

1670

12.

PHYTOCHEMICAL ASSESSMENT AND METABOLIC FINGERPRINTING OF BOERHAVIA DIFFUSA AND CEPHALANDRA INDICA FROM INDIAN SUB-CONTINENT

The medicinal plants, Boerhavia diffusa and Cephalandra indica are both perennial climbing herbs commonly used in traditional system of medicine for the treatment of several ailments because of their healing properties. The present study aimed to identify the phytochemical constituents of methanolic extracts of these plants, followed by their metabolic fingerprinting, which was carried out by HPTL...

R. Irshad *, S. Ahmed and M. Husain

Department of Biotechnology, Molecular Virology Lab, Jamia Millia Islamia, New Delhi, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5338-46

5338-5346

3528

1673

4.

AN OVERVIEW OF BACTERIOPHAGE THERAPY OVER ANTIBIOTICS; AS AN ALTERNATIVE FOR CONTROLLING BACTERIAL INFECTIONS

Lung cancer is a malevolent lung growth characterized by unrestrained cell expansion in tissues of the lung. EGFR is occupied dissimilar fundamental presentation of cancer cells that includes expansion of cells, enlargement, propagation, apoptosis regulation etc. make it a prime objective for lung cancer. EGFR is a tyrosine kinase inhibitor that is proposed in epithelial cells. EGFR inhibitors are...

P. Joshi, A. Singh * and D. Bisht

Department of Pharmaceutical Sciences, Bhimtal Campus Bhimtal, Kumaun University Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(3).1033-41

1033-1041

3528

2110