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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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14.

MOLECULAR DOCKING AND ADMET STUDIES OF BIOACTIVE COMPOUNDS OF RHIZOPORA MUCORNATA AGAINST BACTERIAL ENZYME PROTEIN TYROSINE PHOSPHATASE

Objective: The bioactive compounds of Rhizopora mucornata were docked against the bacterial enzyme protein tyrosine phosphatase to determine the potential inhibition. In this research the molecular docking analysis of drug compounds with virulent protein was studied. Material and Methods: Protein Tyrosine phosphatase is an enzyme that is being present in staphylococcus infection that plays an impo...

R. A. Biswal, A. Sharma, A. Aishwariya and V. Pazhamalai *

Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1635-42

1635-1642

3536

1390

4.

VIRUSES AS HIJACKERS

Viruses are like hijackers. They invade living, normal cells, and replicate and create other viruses like themselves using those cells. This can destroy, harm, or change the cells and cause sickness. Various viruses in the human body invade other cells, such as the liver, respiratory system, or blood. Viruses are too small germs. Inside a protein matrix, they are made of genetic material inside of...

S. Sivakrishnan * and J. Kavitha

Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3564-73

3564-3573

3536

1326

59.

EVALUATION OF N-(6-CHLOROBENZOTHIAZOL-2-YL)-2-(SUBSTITUTEDAMINO)ACETAMIDE FOR ITS ANTI-BACTERIAL ACTIVITY

In the present study, a series of some novel benzothaizole derivatives (BZT 1-10) were screened for their antibacterial activity against S. typhi, S. dysenterae, E. coli, S.aureus and B. subtlis employing Disc Diffusion method and taking Agar as culture media. Streptomycin (25µg/ml) was used as a standard drug. The solvent, DMSO used for the preparation of compounds did not show inhibition agains...

Pranav Prabhat*, Sreemoy Kanti Das, Kausar Shafaat and J.P. Anand

Faculty of Pharmacy, S. Sinha College, Aurangabad- 824 102, Bihar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2769-74

2669-2674

3535

1547

67.

HETEROLEPTIC MONONUCLEAR RUTHENIUM(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES

Mononuclear ruthenium(II) complexes of the type [Ru(bpy)2(L)] (PF6)2, where L=4,5-bis(4-dimethyaminophenyl)-1H, 1 'H-2,2'-biimidazole (1) and 4,5-bis (4-fluorophenyl) - 1H, 1' H-2,2'-biimidazole (2) have been synthesized and characterized by elemental analyses and  spectroscopic techniques such as UV-visible, IR and ESI-MS. The redox behavior of the complexes has been studied by cyclic and differ...

M. Kiruthika and P. Dharmalingam *

Department of Chemistry, Urumu Dhanalakshmi College, Tiruchirappalli, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(3).1485-91

1485-1491

3533

1623

4.

AN OVERVIEW OF BACTERIOPHAGE THERAPY OVER ANTIBIOTICS; AS AN ALTERNATIVE FOR CONTROLLING BACTERIAL INFECTIONS

Lung cancer is a malevolent lung growth characterized by unrestrained cell expansion in tissues of the lung. EGFR is occupied dissimilar fundamental presentation of cancer cells that includes expansion of cells, enlargement, propagation, apoptosis regulation etc. make it a prime objective for lung cancer. EGFR is a tyrosine kinase inhibitor that is proposed in epithelial cells. EGFR inhibitors are...

P. Joshi, A. Singh * and D. Bisht

Department of Pharmaceutical Sciences, Bhimtal Campus Bhimtal, Kumaun University Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(3).1033-41

1033-1041

3533

2116

86.

ANTI-GLYCATION EFFECT OF WHITTON ROOT (EULOPHIA NUDA) IN-VITRO CONDITION

Non enzymatic glycation takes place when elevated levels of reduced sugars react with amino groups of proteins and is called as advanced glycation end products (AGEs) are responsible for Diabetes Mellitus. Hydroalcoholic extract of Whitton root (Eulophia nuda) was tested for in-vitro inhibition of non-enzymatic glycation of Immunoglobin G.  Plant extracts have their own importance and now being s...

Dinesh Prasad Yadav*, Ram Charan Chhipa and Balvinder Singh

Department of Biochemistry, Suresh Gyan Vihar University, Mahal Jagatpura, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3502-06

3502-3506

3532

1670

65.

THE SYNTHESIS OF QUINAZOLON-1,3,4-OXADIAZOLE ANALOGUES AND STUDIES OF THEIR ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY

A series of conjugation of two heterocycles 1, 3, 4-oxadiazole and quinazolone were synthesized and screened for antimicrobial as well as antioxidant activity. Compound4-(4-oxo-2-phenyl-quinazoline-3(4H)-yl)-benzohydrazide 3 on cyclization with different aromatic acids in the presence of phosphoryl chloride (POCl3) give different 1, 3, 4-oxadiazole derivatives. Similarly, compound 3 on reaction wi...

V. S. Kulkarni *, D. S. Chavan and G. P. S. Kumar

Department of Pharmaceutical Chemistry, Indira Institute of Pharmacy, Sadavali (Devrukh), Ratnagiri, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1477-84

1477-1484

3532

1961

78.

COMPLEXES OF COBALT(II), NICKEL(II) AND ZINC(II) WITH SCHIFF BASES DERIVED FROM 4-ANISALDEHYDE

A new spectrophotometric method is developed for the determination of artesunate (ARTS) in pharmaceutical preparation and bulk drug. The method involved heat-catalyzed derivatization of the drug with acetic anhydride and concentrated sulphuric acid producing a yellow coloured product peaking at 420.6 nm. The optimum conditions of the reaction and the analytical procedures of the assay were establi...

S. Meena and S. M. Sandhya*

Department of Pharmaceutical Analysis, Devaki Amma Memorial College of Pharmacy, Pulliparamba P.O, Malappuram – 673634, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(12).5111-15

5111-5115

3531

1673

44.

CHARACTERIZATION AND QUANTIFICATION OF ETHYLHEXYLGLYCERIN

Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethyl hexyl group is bound to glycerin at one end by an ether linkage. it has been used as a common ingredient in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. The compound is synthesized by esterfication of 2-Ethylhexanol and epichlorohydrin,...

R. Arla *, J. S. Rao and K. Koumaravelou

Department of Pharmacy, Prist University, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3474-79

3474-3479

3531

1930

12.

PHYTOCHEMICAL ASSESSMENT AND METABOLIC FINGERPRINTING OF BOERHAVIA DIFFUSA AND CEPHALANDRA INDICA FROM INDIAN SUB-CONTINENT

The medicinal plants, Boerhavia diffusa and Cephalandra indica are both perennial climbing herbs commonly used in traditional system of medicine for the treatment of several ailments because of their healing properties. The present study aimed to identify the phytochemical constituents of methanolic extracts of these plants, followed by their metabolic fingerprinting, which was carried out by HPTL...

R. Irshad *, S. Ahmed and M. Husain

Department of Biotechnology, Molecular Virology Lab, Jamia Millia Islamia, New Delhi, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5338-46

5338-5346

3531

1674