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STRUCTURE ELUCIDATION AND THERAPEUTIC APPLICATIONS OF ENDOPHYTIC FUNGI DERIVED BIOACTIVE COMPOUNDS OBTAINED FROM XIMENIA AMERICANA WESTERN GHATS OF KARNATAKA INDIA
The objective of the present investigation was the bioprospection of pharmaceutically vital bioactive compounds from endophytic Thielaviopsis basicola with antagonistic and antioxidant activity isolated from Ximenia americana, Western Ghats of Karnataka, India. The fresh and healthy leaves and roots of Ximenia americana were collected from the forests of Western Ghats of Karnataka, India and subme...
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MEDICATED TATTOOS: A RECENT DRUG DELIVERY APPROACH IN MEDICAL SCIENCE
Trandermal drug delivery systems are potential sources of administrating drugs through and have certain advantages as delivering a therapeutically effective amount of drug across a patient's skin. Medicated Tattoos is one of the upcoming approaches in transdermal drug delivery. Researches reveal that humans from the generations have used tattoos for various reasons like symbol of rank, religious/s...
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SYNTHESIS OF SOME NEW 2-(N-SUBSTITUTED)- 3H- PHTHALAZIN- 1, 4- DIONE DERIVATIVES FOR THEIR ANTIHYPERTENSIVE ACTIVITY
Present study is reporting the result of the synthesis and evaluation of antihypertensive activity for N-substituted pthalazine 1,4-dione derivatives. N-substituted pthalazine 1,4-dione derivatives were synthesized by taking the Heterocyclic system, ethylglycinate, hydrazine hydrate and pthalic anhydride and were subjected to preliminary screening for antihypertensive activity in albino rats. The ...
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DEVELOPMENT AND IN VITRO EVALUATION OF SELF EMULSIFYING FORMULATION FOR EMBELIN
The purpose of present work was to improve the oral bioavailability of embelin by formulating this hydrophobic phytoconstituent as self emulsifying drug delivery system (SEDDS). SEDDS improves the oral bioavailability by overcoming the dissolution step, enzymatic degradation and hepatic first pass metabolism of phytoconstituent. On the basis of solubility study of embelin, ethyl oleate, tween 80 a...
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DEVELOPMENT AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF SEROTONIN HYDROCHLORIDE
The aim of the present work is to develop the formulation the orodispersible tablets of Serotonin hydrochloride. The tablets were prepared by direct compression technique using microcrystalline cellulose (MCC) as directly compressible diluents. Superdisintegrants such as Croscarmellulose sodium (CCS) Sodium starch glycolate (SSG) and Crospovidone were used. Method: Using different concentrations o...
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FORMULATION, OPTIMIZATION AND IN-VITRO EVALUATION OF DICLOFENAC SODIUM LOADED SUSTAINED RELEASE MATRIX TABLET CONTAINING BOTH NATURAL AND SEMI-SYNTHETIC POLYMERS
Objective: The persistence of this effort was to frame, evaluate and examine the impact of natural and semi-synthetic polymer in changing the release rates of matrix tablet loaded with diclofenac sodium. Materials and method: Matrix tablets of diclofenac sodium were made-up by varying the concentrations of both natural polymer i.e Guar gum and semi-synthetic polymer i.e HPMC K4M via straight compr...
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EFFECTS OF GREEN TEA INFUSION AND EPICATECHIN ON DOXORUBICIN-INDUCED RENOCARDIOTOXICITY IN MALE ALBINO RATS
This study aims to assess the preventive effects of green tea infusion and epicatechin on doxorubicin (Dox)-induced kidney and heart injuries and oxidative stress in male Wistar rats. The male Wistar rats administered Dox at an intraperitoneal dose of 4 mg/kg body weight (b.w.)/ week were orally treated with green tea infusion (200 mg/kg b.w.) and epicatechin (25 mg/kg b.w.) every other day for 6 ...
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THE IMPORTANCE OF DOMINANT HAND AT PLACEBO EFFECT OF INERT SPRAY TO MUSCULAR FATIGUE INDUCED EXPERIMENTALLY
Purpose: Placebo effect is a phenomenon where the patient's symptoms can be relieved by a false treatment in pharmacological aspects, most likely because of the patient expectations or believes that the treatment will have success. So, it is a psychological response to the treatment, without being accompanied by the improvement of physical condition. Placebo is often defined as: “Substance or pr...
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IN-VITRO ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS OF BARK OF FICUS RACEMOSA LINN. (MORACEAE)
The plant Ficus racemosa L., is a woody large deciduous tree distributed all over India, and grows in the evergreen forest, moist localities, along with the sides of ravines and banks of streams belonging to the family Moraceae, locally know as Attimara and Hindi known as Gular. Ethnobotanically the bark used for anti-diabetic, wounds, useful in asthma and piles recommended in uropathy and treatme...
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THE SYNTHESIS OF QUINAZOLON-1,3,4-OXADIAZOLE ANALOGUES AND STUDIES OF THEIR ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY
A series of conjugation of two heterocycles 1, 3, 4-oxadiazole and quinazolone were synthesized and screened for antimicrobial as well as antioxidant activity. Compound4-(4-oxo-2-phenyl-quinazoline-3(4H)-yl)-benzohydrazide 3 on cyclization with different aromatic acids in the presence of phosphoryl chloride (POCl3) give different 1, 3, 4-oxadiazole derivatives. Similarly, compound 3 on reaction wi...
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