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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 12 (2021) - Issue 10, October

Review Articles

 
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1.

ROLE OF ROBOTICS IN HEALTH CARE SYSTEM DURING COVID-19 PANDEMIC

The essential part of robots in the medical services framework is principal to limit an individual to individual contact, defilement, and to guarantee cleaning, disinfection. Robots can be defined as an artificially intelligent physical system that is capable of interrelating with the environment. The term robot was coined from the Czech what "robota" which implies serf/worker. Robots are classifi...

K. Padmini, A. Suvarna and I. Neelam *

Department of Pharm D., CMR College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5134-44

5134-5144

424

258

2.

FINGERPRINTING ANALYSIS AND MARKER COMPOUNDS IN QUALITY ASSESSMENT OF PHYTOPHARMACEUTICALS

Since decades, human beings have been utilizing plants to fulfill their food, medicine, and shelter needs. In the modern era plants, plant-derived products are developed as medicine and drug containing phytoconstituents by combining traditional knowledge and modern technologies. The presence of these phytoconstituents is needed to validate qualitatively and quantitatively to serve the purpose of t...

Suvarna Jarande * and Mrinalini Damle

Department of Pharmaceutical Chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5145-60

5145-5160

223

104

3.

A RECENT SURVEY ON CHEMICAL AND BIOLOGICAL SIGNIFICANCE OF ISATIN DERIVATIVES

Isatin, a heterocyclic moiety, is a significant scaffold in medicinal chemistry. Isatin contains a nitrogen atom at position 1 and two ketone groups at positions 2 and 3. It consists of two cyclic rings, one of which is a six-membered ring, and the other is a five-membered ring. It is a resourceful nucleus for the synthesis of several pharmacologically active molecules. Isatin itself acquires an e...

P. Sowmiya * and K. Girija

Department of Pharmaceutical Chemistry, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Puducherry, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5161-73

5161-5173

223

92

4.

HEPATOPROTECTIVE FUNCTION AS WELL AS SOLUBILITY AND ORAL BIOAVAILABILITY OF NANO-BASED SILYMARIN: A POTENTIAL REVIEW

Silymarin is a mixture of flavonolignan and polyphenolic bioactive natural products found in the milk thistle plant Silybum marianum. It has anti-oxidant, anti-inflammatory, anti-cancer, and antiviral activities potentially useful in treating several liver disorders, such as chronic liver diseases, cirrhosis and hepatocellular carcinoma. However, the benefits are curtailed by its extremely poor wa...

Jyotirmoy Bhattacharyya *, Abdul Baque Ahmed and Sumit Das

Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical, Science, Azara, Hatkhowapara, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5174-84

5174-5184

214

85

5.

IMPACTS OF HUMAN PHARMACEUTICALS ON FISH HEALTH

Human pharmaceuticals and their metabolites affect the endocrine system and physiology of aquatic wildlife, which is an important global ecological concern. The published data from open-source toxicology and worldwide web resources reveal about 175 pharmaceuticals that can affect estrogen pathways to disrupt the endocrine system and metabolism. Such studies demand additional investigations on fish...

Bhawna Srivastava and P. B. Reddy *

Government PG College, Ratlam, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5185-94

5185-5194

207

85

6.

LIPID NANOCARRIERS FOR NOSE TO BRAIN DELIVERY: RECENT UPDATES

In recent years, the nasal route is gaining increasing importance for systemic administration of drugs and targeting to brain. The drug delivery to the brain is limited due to several factors, including presence of blood-brain barrier, enzymatic degradation, and efflux of drug by P-glycoprotein. Nasal route is employed to target the brain using various direct pathways via nasal mucosa and to bypas...

S. S. Deshkar *, M. S. Jadhav, S. A. Todmal and S. V. Shirolkar

Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5195-07

5195-5207

104

45

7.

GREEN SYNTHESIZED GOLD NANOPARTICLE: A NOVEL APPROACH TOWARDS BIOMEDICAL AND PHARMACEUTICAL APPLICATIONS

Green synthesized gold nanoparticle is one of the most promising drug delivery approaches with biocompatibility and biodiversity. Various plant sources such as Aegle marmelos, Eugenia jambolana, Soursop, Persea Americana, Terminalia chebula, Aloe arborescens, Musa paradisiacal, Alternanthera philoxeroides, Cissus quadrangularis, Sterculia acuminate, Garciniaindica choissy, Eucalyptus globulus, Ros...

Dilipkumar Pal * and Supriyo Saha

Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5208-28

5208-5228

80

42

8.

THE POTENTIAL OF INDONESIAN TRADITIONAL HERBAL MEDICINE AS IMMUNOMODULATORY AGENTS: A REVIEW

The prevalence of infectious diseases in the world, including in Indonesia, has increased significantly. One of the factors of death due to infectious disease is decreasing the human body's immune system. Therefore, studies on immunomodulatory agents need further investigation. Many studies have shown that secondary metabolite compounds contained in plants have immunomodulatory properties. These c...

Erlia Anggrainy Sianipar

Department of Pharmacy, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia.

DOI: 10.13040/IJPSR.0975-8232.12(10).5229-37

5229-5237

84

38

9.

AN UPDATE ON POTENTIAL THERAPEUTIC ACTIONS OF BOSWELLIC ACIDS

In recent years, natural products such as Boswellic acids (BAs) have attracted researchers around the globe because of their significant potential against various diseases without any toxic effects. Boswellic acids, which belong to the pentacyclic triterpenes type of class, are extracted from the gum-resin portion of Boswellia serrata and many other different species such as Boswellia sacra, Boswe...

Parth Rastogi and Parmesh Kumar Dwivedi *

Amity Institute of Pharmacy, Lucknow, Amity University Uttar Pradesh, Sector 125, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5238-52

5238-5252

70

44

10.

A SYSTEMATIC REVIEW OF UNANI FORMULATIONS FOR POTENTIAL IN TREATMENT OF HEPATOCELLULAR CARCINOMA

Background: Hepatocellular carcinoma (HCC) represents the third most common cause of death in the world. It is resistant to most chemotherapeutics and associated with a poor prognosis. Unani system of medicine offers effective treatment for various chronic liver diseases. These treatments have shown reversal of inflammation and fibrosis in various clinical conditions. In the present study, we have...

Z. A. Shaikh, S. S. Kamyab, M. M. Deshpande, G. J. Mulla, N. S. Bhatt and A. S. Moghe *

Department of Cell and Molecular Biology, Rajiv Gandhi Institute of IT & Biotechnology, Bharati Vidyapeeth Deemed to be University, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5253-63

5253-5263

78

39

11.

A COMPLETE RECAPITULATION OF A DRUG DELIVERY BASED ON OSMOTIC PRESSURE: AN OSMOTIC DRUG DELIVERY SYSTEM

Conventional dosage forms are the systems that don't have complete control on their drug release, and also there is no control over the effective concentration at the target site. So in order to overcome this problem the osmotic drug delivery system was developed for the controlled delivery of drugs. This osmotic drug delivery system includes dosage forms for oral administration and implantable sy...

Alla Monisha *, M. Mohan Varma, D. Basava Raju

Department of Formulation Research & Development, Aurigene Pharmaceutical Services (Subsidiary of Dr. Reddy’s Laboratories), CPS, Miyapur, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5264-80

5264-5280

82

43

12.

SOLID DISPERSION EXTENDED-RELEASE SYSTEM: A REVIEW

Solid dispersion extended-release system involves amorphization of drug material that leads to creating an alternative pathway for poorly water-soluble drugs. The drug increases solubility due to an increase in apparent solubility of the particular drug. Crystalline lattices of the drug are disturbed during its manufacture, which minimizes the crystal packing energy for solubilization. Along with ...

Kishore Kumar Puhan *, Suburayalu Raja and N. K. Choudhary

Department of Pharmacy, B. R. Nahata College of Pharmacy, Mandsaur University, Rewas Dewda Road, SH - 31, Mandsaur, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5281-91

5281-5291

68

39

13.

1, 3, 4-OXADIAZOLE AND ITS POTENCY: A REVIEW

Heterocyclic compounds represent the important structural key in pharmaceutical medicinal chemistry. In literature, five-membered heterocycles are reported to be a core moiety of various pharmaceutical drugs. Oxadiazole or furadiazole is a five-membered heterocyclic nucleus and is considered to be derived from furan by replacement of two methane (-CH=) groups by pyridine type nitrogen. Oxadiazole ...

Hasit Vaghani *, Shweta Patel and Sarika Patel

Department of Chemistry, Mehsana Urban Institute of Sciences, Ganpat University, Kherva, Mahesana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5292-99

5292-5299

67

33

14.

COVID-19 PANDEMIC-A FORTUNATE SCENARIO FOR PHARMACEUTICAL SCIENTISTS

Covid-2019: The pandemic that shook the entire world. There is no sarcasm if one says there will be a Pre and Post- COVID-19 world. Worldwide, millions of cases have been identified, and heaps have died. So many nations worldwide have issued a lockdown to stop the coronavirus's unfolding, which triggered giant financial fallout. Like each and every incident has two dimensions, Covid-19 possesses b...

K. Swapna * and Y. Padhmanabha Reddy

Department of Pharmaceutical Analysis, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) – Autonomous, K. R. Palli Cross, Anantapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5300-07

5300-5307

77

32

Research Articles

 
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15.

ANTIBACTERIAL ACTIVITY, PHARMACOKINETICS AND MOLECULAR DOCKING OF PHYTOCHEMICALS FROM RICINUS COMMUNIS` LEAF EXTRACT

To evaluate the antibacterial activity, pharmacokinetics and molecular interaction of the compounds from Ricinus communis` leaf extract. Antibacterial activity was assessed by using the micro-dilution method. The chemical constituents of the methanolic leaf extract were assessed by using gas chromatography-mass spectrophotometry (GC-MS). The drug-like and toxicity properties of the phytocompounds ...

Tsolanku Sidney Maliehe *, Sandile Nduduzo Mboyazi, Mduduzi Innocent Nqotheni, Sbongiseni Buthelezi and Jabulani Siyabonga Shandu

Department of Biochemistry and Microbiology, University of Zululand, Kwa Dlangezwa, South Africa.

DOI: 10.13040/IJPSR.0975-8232.12(10).5308-18

5308-5318

187

107

16.

BIOLOGICAL PROPERTIES OF EXTRACTS FROM LOCALLY GROWN BANANA LEAVES INDICATE THEIR POSSIBLE USE FOR WOUND DRESSING IN ARUSHA, TANZANIA

This study assessed the biological properties and safety profile of extracts from locally grown banana leaves in Arusha (Tanzania), to affirm their possible use for wound dressing. Screening for phytoconstituents in extracts from studied banana plant species, ijuhi inkundu (IJ) mlelembo (ML) and kimalindi (KIM), revealed the presence of various secondary metabolites; anthraquinones, alkaloids, fla...

A. Telesphory *, S. Grosche, J. M. Vianney, E. Sauli and H. Swai

Nelson Mandela African Institution of Science and Technology (NM-AIST), Arusha, Tanzania.

DOI: 10.13040/IJPSR.0975-8232.12(10).5331-31

5319-5331

164

74

17.

DEVELOPMENT AND CHARACTERIZATION OF ORODISPERSIBLE TABLETS CONTAINING PARACETAMOL GRANULES COATED WITH TASTE-MASKING TECHNOLOGY

Orodispersible tablet technology allows tablets to be administered without the need for additional water, which would increase pediatric patient compliance. In this paper, an orodispersible paracetamol tablet formulation with flavor masking technology was developed. For this purpose, the methacrylic acid-derived polymer, Eudragit® E100, has the ability to form films on particles, which are insolu...

L. C. A. Laís Costa Ayub *, H. T. T. M. Helena Teru Takahashi Mizuta and V. M. Vinícius Müller

Ourofino Animal Health, Ribeirão Preto, SP – Brazil.

DOI: 10.13040/IJPSR.0975-8232.12(10).5332-40

5332-5340

180

72

18.

SYNTHESIS AND ANALGESIC ACTIVITY OF [1,3,4]-THIADIAZOLE-[1,3-DIONE]-ISOINDOLE DERIVATIVES

Background: During recent years, there has been a large investigation on different classes of thiadiazole compounds, many of which were found to possess an extensive spectrum of pharmacological activities. This study was undertaken to synthesize and evaluate the analgesic activity of [1,3,4]-thiadiazole-[1,3-dione]-isoindole derivatives. Methods: The purity of the synthesized compounds was checked...

L. Sanathoiba Singha *, Vicky Bareh and Faruk Alam

Rahman Institute of Pharmaceutical Sciences and Research, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5341-52

5341-5352

157

65

19.

ANTIMICROBIAL ACTIVITY OF TERMINALIA BELLERICA (GAERTN.) ROXB. AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS SAPROPHYTICUS

The present study investigates the isolation and identification of Multi-Drug Resistant bacteria from Hospital Effluent and the determination of Antimicrobial activity of Terminalia bellerica (Roxb.) against the isolated Multi Drug-Resistant Bacteria. Hospital effluent was collected and screened for the presence of Drug resistance phenotype against five different antibiotics, and the isolated bact...

Tamalika Chakraborty, Sumana Chatterjee *, Lopamudra Datta and Abhijit Sengupta

Department of Pharmacy, Guru Nanak Institute of Pharmaceutical Science and Technology, 147/F, Nilgunj Road, Panihati, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5353-63

5353-5363

175

86

20.

EVALUATION OF CORRELATION BETWEEN GLYCATED HEMOGLOBIN AND HEMATOLOGICAL INDICES IN TYPE 2 DIABETES MELLITUS PATIENTS

Diabetes Mellitus increases the risk of both microvascular and macrovascular complications, out of which CVD affects approximately 32.2% of people with Type 2 Diabetes Mellitus globally. It is predicted that for every 1% increase in HbA1c is associated with a 30% increase in all-cause mortality and a 40% increase in CVD mortality in T2DM patients. This study aims to evaluate the correlation of Hb...

Kumaraswamy Barla * and S. V. Kavya

Department of Pharmacology and Pharmacy Practice, Sir C. R. Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5364-70

5364-5370

55

40

21.

CHARACTERIZATION OF NOVEL SOFT ROT CAUSING GRAM-NEGATIVE BACTERIA SJCTSSP01 & ITS MANAGEMENT USING PHYTOEXTRACTS

Aim: The present study focuses on studying the soft rot-causing bacteria in Solanum tuberosum and the activity of phytoextracts against the pathogen to prevent/control this infection. Lantana camara and Clerodendrum infortunatum has been well known for their antibacterial activity and widely used in Ayurveda, these plants were investigated for their antibacterial activity against the isolated path...

V. J. Gandhimathi, N. M. Parvathy Sumam, Sherin S. Kizhukarakkattu, Tanisha Dey and Lokesh Ravi *

Department of Botany, St. Joseph’s College (Autonomous), Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5371-77

5371-5377

89

49

22.

COMPARATIVE STUDY OF ANTI-ANXIETY AND ANTI-DEPRESSANT POTENTIALS OF LEAVES AND ROOT OF METHANOLIC EXTRACT FROM ACHYRANTHES BIDENTATA BLUME ON MICE

Anxiety and Depression is the most prominent and crippled Neuropsychiatric Disease. World Health Organization (WHO) reported is the most burdensome disease of society. We therefore aimed at evaluating the Anti-Anxiety and Anti-depressant potential using Achyranthes bidentata Blume (Chinese name Huainiuxi). This study compared Leaves and Root part of Achyranthes bidentata methanolic extract (ABME) ...

M. Kumar and G. Thamotharan *

Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Salem, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5378-87

5378-5387

66

33

23.

ANTIPARKINSONIAN ACTIVITY OF HYDROALCOHOLIC EXTRACT OF THE STEMS OF CAPPARIS DECIDUA (FORSSK.) EDGEW.

The goal of the research is to analyze the antiparkinsonian activity of hydroalcoholic extract of the stems of Capparis Decidua (HECD). Themost common neurodegenerative condition which stand second is Parkinson. It is reported by dopaminergic neuron loss in the striatum's substantia nigra & dopamine loss (DA). Capparis Decidua plant is used as anti-inflammatory, laxative, anti-diabetic, anthel...

Shaheen Khan * and Imtiyaz Ansari

Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5388-95

5388-5395

67

29

24.

DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR THE PHARMACOKINETIC STUDY OF FAMOTIDINE SNEDDS IN RATS USING RP-HPLC

A selective and high throughput RP-HPLC method was developed to detect and quantify Famotidine in rat plasma using Ranitidine hydrochloride as an internal standard (IS). After liquid-liquid extraction, the analyte and the internal standard were chromatographed on Enable 18H (5µ, 250×4.6mm) C18 column using 20 µL injection volume with a run time of 15 minutes. An isocratic mobile phase consistin...

Amani Baquer Shareef *, Y. Padmavathi, N. Raghavendra Babu and P. Ravi Kumar

Department of Pharmaceutical Analysis, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5396-06

5396-5406

58

35

25.

CONCURRENT PROCESS VALIDATION OF GLIBENCLAMIDE 2.5 MG TABLET

The present study of concurrent process validation delivers an extraordinary degree of quality assurance that a specific process for manufacturing of Glibenclamide Tablets will consistently manufacture a product that meets its predetermined quality attributes and specifications. Glibenclamide is generally suggested for the treatment of type II diabetes mellitus and it is mainly a sulfonylurea deri...

Prashant B. Patil, Vilas L. Badgujar, Rajendra D. Wagh and Kundan H. Deore *

NES’s Gangamai College of Pharmacy, Nagaon, Dhule - 424005, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5407-13

5407-5413

61

32

26.

TROXERUTIN IMPROVES INSULIN SIGNALING IN TNFα TREATED 3T3-L1 ADIPOCYTES

Chronic low-grade inflammation of adipose tissue is associated with obesity and insulin resistance (IR). The aim of this study is to determine the effect of troxerutin (TX) on insulin signaling in tumor necrosis factor α (TNFα) treated 3T3-L1 adipocytes. Differentiated 3T3-L1 adipocytes were pre-treated with TX, elastatinal (ELAS) or sodium salicylate (SAL) before exposure to recombinant human T...

R. Vidhya, U. Ajay Krishnan and C. V. Anuradha *

Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5414-23

5414-5423

90

34

27.

SYNTHESIS, CHARACTERIZATION AND ANTICANCER ACTIVITY OF PIPERAZINE AMIDE DERIVATIVE

Piperazine is a nitrogen-containing heterocyclic compound and has fascinating applications in drug discovery and development. In the present study, novel 4-(benzo[1,3]dioxol-5-ylmethyl) piperazine amide derivative was prepared by acid amine coupling of 1-piperonyl piperazine derivative and benzoic acid. Synthesized compound was characterized by IR, NMR and mass spectral studies. Further, in-vitro ...

B. K. Sagar *, M. Dileep Kumar, Mahesh Bhat, E. Vijaya Sekhar and M. Supreeth

Department of Chemistry, MDRPU Science College, Varakodu, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5424-30

5424-5430

67

30

28.

ANTIGENOTOXIC EFFECTS OF SILYMARIN AGAINST NICKEL CHLORIDE MEDIATED DNA DAMAGE IN CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES

DNA damage induced by Nickel chloride in lymphocytes has been studied in-vitro. The sister chromatids exchange and single-cell gel electrophoresis (SCGE), or comet assay were used to measure the level of DNA damage in terms of SCE frequency and comet parameters. Silymarin is a natural protective compound, isolated from Silybum marianum seeds and reported for its anti-genotoxic properties. In this ...

Veena Vishwakarma, Sunil Kumar, Bharti Yadav, Ranjan Gupta, Neeraj K. Aggarwal and Anita Yadav *

Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5431-38

5431-5438

54

35

29.

FORMULATION AND EVALUATION OF METOPROLOL LOADED SOLID LIPID NANOPARTICLES

The main aim of the present study is to formulate and evaluate solid lipid nanoparticles of Metoprolol. Metoprolol is an anti-hypertension drug used in the treatment of hypertension, angina pectoris, and heart failure. Metoprolol belongs to BCS class-I, which has high solubility and high permeability. The drug needs to be administered frequently (2-3 times a day), and it has side effects and poor ...

G. Bhanusri * and P. Tripura Sundari

R. B. V. R. R Women’s College of Pharmacy, Barkatpura, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5439-45

5439-5445

88

39

30.

PHARMACOGNOSTICAL EVALUATION OF TERMINALIA CHEBULA FRUIT EXTRACT AGAINST RESPIRATORY TRACT INFECTIOUS PATHOGENS

To evaluate the antibacterial activity of methanolic extract of Terminalia chebula, commonly called Haritaki was tested against respiratory tract infection-causing bacteria. The antibacterial activities were assessed by agar well diffusion, broth dilution and time-kill methods. It showed the best antibacterial activity against Klebsiella pneumoniae among the tested respiratory infection-causing ba...

S. Anasuya, Vishnupriya Benaltraja * and Anbarasi Gunasekar

Department of Biotechnology, Kongunadu Arts and Science College, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5446-57

5446-5457

60

32

31.

DEVELOPMENT OF HERBAL NIOSOMES FOR WOUND HEALING

Traditionally Psidum guajava has been used for the treatment of several kinds of disorders. The component quercetin a flavonoid that is present in the guava leaves, is responsible of having wound healing properties, so the aim and objective of the study was to Develop Herbal loaded Niosomes for the treatment of Wound Healing. To enhance the transport and efficacy of many materials through stratum ...

V. Swetha * and G. Uma Rani

Department of Pharmaceutics, RBVRR Women’s College of Pharmacy, Affiliated to Osmania University (Osmania University), Barkatpura, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5458-68

5458-5468

62

38

32.

EVALUATION OF ANTIOXIDANT ACTIVITY OF LEAVES EXTRACT OF MORINGA CONCANENSIS NIMMO ON ISOLATED FROG’S HEART

Moringa Cocanensis Nimmo is one of the important medicinal plants belonging to the family moringaceae. Moringa Cocanensis Nimmo has antipyretic, antihelmintic, antimicrobial, hepatoprotective, and anticancer activities. It is one of the most noted systems of medicine in the world. Ayurveda is based on the hypothesis that everything in the universe is composed of five basic elements viz. space, air...

Sridhar Vanga * and Shravan Kumar Dholi

Department of Pharmaceutical Chemistry, Beside LMD Police Station, Ramakrishna Colony, Karimnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10). 5469-75

5469-5475

59

38

33.

DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING HPTLC METHOD FOR ESTIMATION OF CELECOXIB AND AMLODIPINE BESYLATE FROM SYNTHETIC MIXTURE

The current research paper describes a highly specific, reproducible, and efficient stability-indicating HPTLC method for estimation of Celecoxib and Amlodipine Besylate from its synthetic mixture. Chromatographic separation and quantification carried out on Merck HPTLC aluminum sheets of silica gel 60 F254 using Chloroform: Acetone: Toluene: Methanol in the ratio of 5:3:2:0.5 v/v/v/v as solvent s...

B. Mehta *, P. Patel, V. Yadav and K. Detholia

Department of Pharmaceutical Quality Assurance, Smt. S. M. Shah Pharmacy College, Amsaran, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12 (10). 5476-85

5476-5485

56

33

34.

FORMULATION AND IN-VITRO EVALUATION OF METFORMIN SUSTAINED RELEASE MATRIX TABLETS

Sustained released dosage form having an advantage over immediately release drug delivery system by continuous release of medicaments for a specific period in a prolonged manner. Diabetes mellitus (DM) is a common test endocrine issue that influences in excess of 100 million individuals ls around the world. Type II diabetes is characterized by peripheral insulin resistance and impaired insulin sec...

V. Rama Rao *, P. Ravi and K. E. Pravallika

University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(10). 5486-93

5486-5493

72

78

35.

EVALUATION OF ANTI-DIABETIC ACTIVITY OF CARALLUMA ADSCENDENS WHOLE PLANT IN DITHIZONE INDUCED DIABETIC RATS

This study was aimed to evaluate the anti-diabetic activity of Ethanolic extract of the whole plant administered at different dosages (100 mg/kg and 200 mg/kg) for 21 days in Dithizone-induced diabetic rats using Glibenclamide as a standard drug (hypoglycemic drug). For the study, rats were divided into five groups of six animals each. Group, I served as control, Group II served as diabetic contro...

Divya Yada *, T. Sivakkumar and M. Sudhakar

Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad- Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10). 5494-99

5494-5499

55

35

36.

HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF HYPTIS SUAVEOLENS AGAINST ARSENIC-INDUCED HEPATOTOXICITY IN WISTAR RATS

The present study was to evaluate Hepatoprotective activity of aqueous extract of Hyptis suaveolens whole plant (AEHS) against Sodium arsenite (2.5 mg/kg) induced hepatotoxicity in Wistar rats for a period of 28 days. Rats were divided into five groups, each with 6 rats. Except for group I, all remaining groups was served with Sodium arsenite oral administration to induce hepatotoxicity prior to s...

Deepthi Yada *, T. Sivakkumar and Nimmagadda Srinivas

Department of Pharmaceutical Chemistry, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally, Secunderabad, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10). 5500-04

5500-5504

59

35

37.

RASAGILINE MESYLATE, A BCS CLASS III DRUG; EX-VIVO PERMEATION ENHANCEMENT STUDY THROUGH EXCISED RAT ABDOMINAL SKIN

Rasagiline Mesylate (RM), an antiparkinson drug, belongs to BCS class III drug having high solubility with low permeability. It undergoes extensive first-pass metabolism with oral bioavailability of only 35%. In the present research work, efforts were made to improve its permeation as requisite for the transdermal drug delivery system. RM was authenticated by determination of melting point. Furthe...

B. K. Satheeshababu *, G. Rohith, V. G. Joshi and R. Sadashivaiah

Department of Pharmaceutics, Government College of Pharmacy, P Kalinga Rao Road, Subbaiah Circle, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(10). 5505-11

5505-5511

60

32

38.

INFLUENCE OF ALLICIN ON PHARMACOKINETICS AND PHARMACODYNAMICS OF PIOGLITAZONE: AN HERB-DRUG INTERACTION STUDY IN RATS

Many herbs/phytochemicals are proved to have anti-diabetic properties and patients in the treatment of diabetes increased their usage. Administration of herbs and allopathic drugs has a chance of interaction between them, leading to alterations in pharmacokinetics and pharmacodynamics of the drug. The present study was aimed to know the influence of phytoconstituent (Allicin) on the pharmacokineti...

Pavani Uppu and Narsimha Reddy Yellu *

University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5512-16

5512-5516

85

34

39.

WATER-SOLUBLE VITAMIN IN TEN WILD EDIBLE FRUITS CONSUMED BY THE TRIBAL PEOPLE OF NORTH-EASTERN REGION IN INDIA: SIMULTANEOUS ESTIMATION BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) METHOD

The present study aimed to develop a reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of water-soluble vitamins like ascorbic acid (C), thiamine (B1), riboflavin(B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6) and folic acid (B9) in ten potent wild edible fruits named Artocarpus gomezianus, Baccurea sapida, Cyclanthera pedata, Flacourtia jang...

Tapan Seal *, D. Saha, K. Sunita, Kausik Chaudhuri and Basundhara Pillai

Plant Chemistry Department, Botanical Survey of India, Acharya Jagadish Chandra Bose Indian Botanic Garden, Shibpur, Howrah, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5517-25

5517-5525

65

37

40.

PHENOLIC ACID DERIVATIVES AS PRESERVATIVES: SYNTHESIS, ANTIOXIDANT, ANTIMICROBIAL POTENTIAL AND THEIR PRESERVATIVE EFFECTIVENESS

Natural phenolic acids alkyl esters viz methyl, ethyl, propyl was synthesized and characterized by spectral means FTIR, 1HNMR, and 13CNMR. All the synthesized esters were examined for their antimicrobial potential, preservative efficacy and antioxidant potential. Among the synthesized ester derivative caffeic acid and gallic acid, derivatives were displayed excellent antioxidant and antimicrobial ...

Sumit Sigroha, Amit Lather and Anurag Khatkar *

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5526-37

5526-5537

58

25

41.

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF OLANZAPINE AND FLUOXETINE FROM BULK AND TABLET DOSAGE FORM BY Q-ABSORBANCE RATIO METHOD

Depression is a common mental disorder that presents with depressed mood, loss of interest or pleasure, decreased energy, feelings of guilt or low self-worth, disturbed sleep or appetite and poor concentration with anxiety. Olanzapine is a second-generation antipsychotic (SGA) or atypical antipsychotic. It has attracted considerable interests due to its wide range of therapeutic and pharmacologica...

H. J. Vekaria * and V. J. Parmar

School of Pharmacy, RK University, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5538-44

5538-5544

43

34

42.

A PROSPECTIVE STUDY ON CORTICOSTEROID USAGE AND INCIDENCE OF CORTICOSTEROID-INDUCED HYPERGLYCEMIA IN A TERTIARY CARE HOSPITAL

Corticosteroids are a widely used class of drugs for respiratory, autoimmune, gastrointestinal, and dermatological conditions. Despite the efficacy of steroids, they have a wide variety of side effects. However, SIH remains the most misdiagnosed side effect. Undiagnosed SIH will precipitate DM, increases the morbidity and length of hospital stay, especially when pre-existing risk factors are prese...

P. Rama *, U. Neeha, V. Ravikumar, Psusreethanair and M. Vignesh

Department of Pharmacy Practice, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5545-52

5545-5552

59

32

43.

COW URINE- A PANACEA

Cow urine is considered a Sanjeevani–a medicine capable of curing any disease according to ancient manuscripts from Vedic times. The present study was conducted to validate the medicinal properties of cow urine in a scientific manner. The cow urine sample was procured from Indian indigenous cow Bos indicus from Bombay Panjrapole, Bhuleshwar, Mumbai, and commercial gaumutra from the local market....

Priyanka Lakhani, Kunj Joshi, Aditi Kulkarni and Suruchi Jamkhedkar *

Department of Life Sciences, University of Mumbai, Vidyanagari campus, Santacruz (East), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5553-61

5553-5561

105

34

44.

AN IN-VITRO INVESTIGATION INTO THE DOSE-DEPENDENT ACID-NEUTRALIZATION EFFECT OF ANTACID FORMULATIONS ON THE GHANAIAN MARKET

The recommended doses of antacids by some manufacturers are in ranges. However, dosing decisions on antacids should be based on acid-neutralizing capacities (ANCs). This study evaluated the ANCs of different doses of antacids. Twenty-two antacids (3 granular, 5 tablet and 14 suspension formulations) were evaluated for their ANCs at half, minimum, and double their recommended adult doses. All the p...

E. Orman, A. Mensah, Y. Saaka and H. Amekyeh *

Department of Pharmaceutical Chemistry, Department of Pharmaceutics, School of Pharmacy, University of Health and Allied Sciences, PMB 31, Ho, Ghana.

DOI: 10.13040/IJPSR.0975-8232.12(10).5562-69

5562-5569

63

38

45.

NANOSPONGES AS NOVEL CARRIER FOR TOPICAL DELIVERY OF LULICONAZOLE -AN ANTIFUNGAL DRUG

The main goal of this work is to formulate nanosponges and access its suitability to deliver Luliconazole for topical application, to improve its therapeutic effect, better dispersion and good storage. Nanosponges are water-soluble, which does not mean that molecules are chemically decomposed in water but that nanosponge particles are mixed with water and used as a carrier fluid. Compared with tra...

B. S. Wakure *, M. A. Salunke, P. T. Mane, S. R. Awale, R. D. Shinde and S. S. Eklinge

Vilasrao Deshmukh Foundation, Group of Institutions, VDF School of Pharmacy, Latur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5570-83

5570-5583

70

53

46.

A STUDY ON THE ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF SCUTELLARIA DISCOLOR COLEBR IN EXPERIMENTAL ANIMALS

The genus Scutellaria has many species.  But only a few species are investigated for the treatment of many ailments. Despite the extensive use of traditional medicine against several diseases, scientific studies of Scutellaria discolor are less. The present study is taken up to investigate the analgesic and anti-inflammatory actions of the acetone extract of S. discolour (SDA)using tail flick met...

Joychandra Oinam, Laishram Babycha * and Laishram Surbala

Department of Pharmacology, Jawaharlal Nehru Institute of Medical Sciences, Porompat, Imphal East, Manipur, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5584-88

5584-5588

64

41

47.

NEPHROPROTECTIVE EFFECT OF CUMINUM CYMINUM SEEDS EXTRACT ON DIABETIC MICE MODEL

Diabetes mellitus is a metabolic condition characterized by insulin resistance, or poor secretion, or both. There are several side effects associated with drugs available to cure diabetes. The most common side effect is neurodegenerative. The objective of the present research was to evaluate the efficacy of Cuminum cyminum seed against diabetes and also to evaluate its nephroprotective power in th...

Roushan Kumari , Arun Kumar Singh, Sneha Navin and Abhinav *

School of Biological Engineering & Sciences, Shobhit University Gangoh, Saharanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5589-94

5589-5594

76

34

48.

FORMULATION AND EVALUATION OF ORAL ANTI-DIABETIC IN-SITU GEL SYSTEM OF PIOGLITAZONE

Pioglitazone is an oral anti-diabetic agent used in treating class – II diabetes mellitus. T1/2of pioglitazone was 3-6 hrs and is eliminated rapidly. Hence sustained release is needed to prolong its duration of action and to increase its oral bioavailability. The main aim of the study was formulation and evaluation of an in-situ gel system of Pioglitazone to increase its bioavailability as a con...

B. Padmasri * and R. Nagaraju

Department of Pharmaceutical Technology, Sri Venkateswara College of Pharmacy, Etherla, Srikakulam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5595-03

5595-5603

75

34

49.

DOCKING ANALYSIS OF SUBSTITUTED 2-PHENYL-1H-INDOL-3YL GLYOXYLAMIDE AS INHIBITORS OF TUBULIN POLYMERIZATION- POTENTIAL NEW ANTICANCER AGENTS

Indibulin (N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid; ZIO-301 or D-24851) is a novel synthetic, orally active anti-mitotic agent that binds tubulin, destabilizes microtubulin polymerization, and arrests tumor cell growth at the G2/M phase. Its tubulin binding site is distinct from that of other microtubulin inhibitors such as taxanes, colchicines, and vinca alkaloids. Many resea...

C. Buvana *, R. Suresh, Y. Haribabu and Avinash Raveendran

Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Palakkad, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5604-12

5604-5612

55

37

50.

CYTOTOXICITY OF EXTRACTS FROM THE PHILIPPINE MARINE SPONGES: PARATETILLA SP., STYLISSA SP. AND PETROSIA (STRONGYLOPHORA) NIGRICANS

This paper reports the cytotoxic activities of the hexane, dichloromethane, ethyl acetate, and methanol fractions of the marine sponges: Paratetilla sp., Stylissa sp., and Petrosia (strongylophora) nigricans, collected from the Island waters of Lipata, Surigao del Norte, Philippines, using the enzymatic reduction of a yellow tetrazolium salt, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium...

H. Luyao * and M. Uy

Department of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City, Philippines.

DOI: 10.13040/IJPSR.0975-8232.12(10).5613-17

5613-5617

60

39

51.

COMPARATIVE STUDIES ON AMARANTHUS VIRIDUS AND AMARANTHUS SPINOSUS

Objective: To correlate the pharmacognostic appearance and physiochemical specification of the leaves of Amaranthus viridus and Amaranthus spinosus. Methods: Pharmacognostical features were scrutinized using fresh and dried powder, and physicochemical assessment was done by WHO guidelines. The phytochemical screenings were adopted for disclosing the existence of phytoconstituents in extracts. Resu...

S. Swarnakumari *, S. Mohan, M. Sasikala and T. Umapoorani

Department of Pharmacognosy, Karpagam College of Pharmacy, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5618-23

5618-5623

61

33