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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 5 (2014) - Issue 4, April

Review Articles

 
Title
Views
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1.

RHEUMATOID ARTHRITIS: AN AYURVEDIC PERSPECTIVE

Ayurveda, an ancient system of medicine explains well about joint disorders like vatarakta, sandhivata, amavata etc. Among these, amavata is a disease which is caused due to hypo-functioning of digestive fire. Rheumatoid arthritis is the disease which keeps clinical similarity with amavata. Ama is main pathogenic factor in the disease amavata. Factors causing formation of ama have direct impact on...

Pramod Kumar Mishra* and N.P. Rai

Department of Kayachikitsa, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1090-94

1090-1094

3493

1053

2.

GASTRORETENTIVE DRUG DELIVERY SYSTEM: AN APPROACH TO ENHANCE GASTRIC RETENTION FOR PROLONGED DRUG RELEASE

Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastroretentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged ...

Ankur Raj Sharma* and Afroz Khan

Jaypee University of Information Technology, Waknaghat-173 234, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1095-06

1095-1106

14856

3465

3.

FACILE METHODS FOR THE EXTRACTION OF ESSENTIAL OIL FROM THE PLANT SPECIES – A REVIEW

Essential oils are a diverse group of natural products. Oils are the important source of aromatic and flavoring chemicals in food, industrial, and pharmaceutical products. Essential oil is a concentrated hydrophobic liquid containing volatile aroma compounds derived from the different parts of the plants. Various extraction methods are used in the manufacture and extraction of essential oils from ...

J. Ranjitha and S. Vijiyalakshmi*

CO2 Research and Green Technologies Centre, VIT University, Vellore-14, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1107-15

1107-1115

3538

2027

4.

REVIEW ON THE CONCEPT OF IMMUNOMODULATION IN AYURVEDA WITH SPECIAL EMPHASIS ON PRAKARA YOGA

An immunomodulator can be defined as a substance, which can influence any constituent or function of the immune system in a specific or nonspecific manner including both innate or adaptive arms of the immune response. The Ayurvedic system of medicine details the concept of immunomodulation by the term Rasayana. The use of herbs for improving the overall resistance of body against common infections...

G.R. Arun Raj*, U Shailaja , Prasanna N. Rao and S. Ajayan

Post graduate Scholar, Department of PG Studies in Kaumarabhritya, Shri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan-573201, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1116-23

1116-1123

5454

1189

5.

1, 3, 4-OXADIAZOLE NUCLEUS WITH VERSATILE PHARMACOLOGICAL APPLICATIONS: A REVIEW

Oxadiazole is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five membered ring. It is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogens (-N=). It is also termed as a lead compound for designing the potent bioactive agents. It has been reported as a surrogate of carboxylic acid and an important synthons in organic che...

Mohammad Arshad

Department of Chemistry, Aligarh Muslim University, Aligarh- 202002, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1000-13

1124-1137

3228

2065

6.

ETHNO-MEDICINAL CLAIMS, PHYTOCHEMISTRY AND PHARMACOLOGY OF SPONDIAS PINNATA: A REVIEW

Spondias pinnata is a well-known plant indigenous to South East Asian countries. The plant has been used intensively in many traditional herbal medicines across the globe. This plant has been known to possess antimicrobial, anti-diabetic, ulcer-protective, anti-cancerous, anti-diarrhoeal, anthelmintic, cytotoxic and hepatoprotective activity. It has also been reported that different parts of the p...

Nilutpal Sharma Bora*, Bibhuti Bhusan Kakoti, Barnali Gogoi and Ashis Kumar Goswami

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1138-45

1138-1145

4466

935

7.

MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM – A COMPREHENSIVE AND PROMISING NOVEL DRUG DELIVERY

Since Dr. Tsuneji Nagai of Hoshi University, Japanin the early 1980’s used the concept of bio adhesion for the delivery of insulin across the buccal mucosa in beagle dogs; several researchers tried a large number of drugs for administration through buccal mucoadhesive dosage forms. The potential of these dosage forms have been found to be tremendous because of their ability to improve the bioava...

Nallathambi Ramasamy* and V. Gopal

Prist University, Vallam, Tanjore-613403, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1146-51

1146-1151

1733

640

8.

SOLID LIPID NANOPARTICLES: AN EFFECTIVE AND PROMISING DRUG DELIVERY SYSTEM- A REVIEW

Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposomes, microparticles and their polymeric counterparts for various application routes since the early 1990s due to their advantages. Solid lipid nanoparticles colloidal drug carrier system gained a lot of popularity among researcher as colloidal drug carriers for incorporating hydrophilic or lipophilic...

Poonam Yadav*, Girish Soni , Alok Mahor , Shashi Alok , Prem Prakash Singh and Amita Verma

Village & Post Khailar, BHEL, Jhansi, 284129, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1152-62

1152-1162

3469

1698

9.

THUJA OCCIDENTALIS L. (CUPRESSACEAE): REVIEW OF BOTANICAL, PHYTO-CHEMICAL, PHARMACOLOGICAL AND TOXICOLOGICAL ASPECTS

Thuja occidentalis called the tree of life is an endemic plant in eastern North America and cultivated in northern Europe and in Brazil as ornamental tree. According to the popular use of this plant has been used in herbal and homeopathic preparations for acute and chronic infections of the upper respiratory tract, warts, as adjunctive antibiotic, immunostimulant. However, these and other data are...

L.D.S. Alves , C.B.M. Figueirêdo , C.C.A.R. Silva , G.S. Marques , P.A. Ferreira , M.F.R. Soares , R.M.F. Silva and P J. Rolim-Neto*

Department of Pharmaceutical Sciences, Federal University of Pernambuco, Brazil

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1163-77

1163-1177

6238

1217

10.

ROLE OF N-ACETYLCYSTEINE IN RESCUE OF MICE HEART

An imbalance between oxidants and antioxidants generates the oxidative stress. Oxidative stress is the major cause of many diseases like cardiovascular, respiratory disease, renal diseases, neurological diseases, cancer, and aging. Cardiovascular complications are the leading cause of mortality in patients so the purpose of this review is to evaluate the effectiveness of N-acetylcysteine (NAC) in ...

Fatima Ali*, Nadia Wajid, Hina Yousaf and Maria Anwer

Institute of Biotechnology and Biochemistry, The University of Lahore, Lahore, Pakistan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1178-82

1178-1182

1870

569

11.

ROLE OF INTERFERONS IN CLINICAL PRACTICE

Interferons were the first cytokines to be used therapeutically as naturally derived and as recombinant forms in humans. Their broad biological activity has resulted in clinical benefits in diseases ranging from infectious (such as viral hepatitis), autoimmune (in particular multiple sclerosis) to neoplastic (lymphomas and carcinomas). Since Interferons enhance the immune system in many ways, they...

Sadiya Khwaja, H.H. Siddiqui and Tarique Mahmood*

Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow-226026, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1183-91

1183-1191

1772

570

12.

HERBAL IMMUNOMODULORS: A REVIEW

The traditional Indian system of medicine (Ayurveda) describes different modalities involved in the prevention and treatment of disease and stresses upon the role of diet, life style and drugs as cornerstones of therapy. Medicinal plant products are known to modify different aspects of human physiology and exert an alleviating influence on several pathophysiological states, and concepts of immunit...

Amit K. Shrivastava*, Anuj K. Srivastava and Dev Prakash

Kailash Institute of Pharmacy & Management, GIDA, Gorakhpur, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1192-07

1192-1207

1974

698

Research Articles

 
Title
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Cited
13.

A STUDY ON FEASIBILITY OF OPTIMIZATION TECHNIQUE IN FORMULATION OF DISPERSIBLE TABLETS BY FACTORIAL DESIGN

In the present research work an attempt was made to study the effect of formulation variables in the development of dispersible tablet by using various super disintegrants. Instead of normal trial and error method an optimization technique was adapted. Amount of Crosscarmellose sodium, SSG and MCC were included as independent variables and hardness, percentage friability, disintegration time and w...

R.E. Ugandar*, Kiran C. Nilugal, Nagarajan Srinivasan and Nagashekhara Molugulu

Faculty of Pharmacy, Asia Metropolitan University, G-8, Jalan Kemacahaya, Taman Kemacahaya, Batu 9, Cheras- 43200, Selangor, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1208-27

1208-1227

1644

479

14.

BOX-BEHNKEN DESIGN FOR DEVELOPMENT AND OPTIMIZATION OF ACETAZOLAMIDE MICROSPHERES

This study describes a Box-Behnken experimental design to optimize the formulation of Acetazolamide (ACZ) loaded microspheres by solvent evaporation method using Eudragit RS100 as a polymer. The prepared microspheres were evaluated for their production yields, particle size distribution, morphology, entrapment efficiency % and drug release characteristics. Box-Behnken design produced fifteen formu...

Marwa H. Abdallah

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1228-39

1228-1239

2377

762

15.

HEPATOPROTECTIVE ACTIVITY OF STEM BARK EXTRACT OF MANGIFERA INDICA L. ON CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY IN WISTAR ALBINO RATS

The effects of aqueous stem bark extract of Mangifera indica in Carbon tetrachloride induced liver injury were investigated. In vivo animal models using Wistar albino rats was used in this experimental study. Carbon tetrachloride was successfully induced by significantly (P<0.001) increasing serum parameters AST, ALT, and ALP and decreasing serum total proteins and albumin levels (P<0.05). S...

Ibrahim Malami*, Muhammad Shamsuddeen Musa , Alhasan M. Alhasan , Muhammad K. Dallatu , Kabiru Abdullahi

Department of Pharmacognosy and Ethnopharmacy, FPS, Usamnu Danfodiyo University, Sokoto, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1240-45

1240-1245

1705

728

16.

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY AND TOTAL TANNIN CONTENT FROM THE LEAVES OF BACOPA MONNIERI (LINN.)

The methanolic leaf extract of Bacopa monnieri Linn. (Family: Scrophulariaceae) was evaluated for its anti-inflammatory activity, and total tannins content in different in-vivo and in-vitro methods. The anti-inflammatory activity was studied using carrageenan and histamine-induced rat paw edema test at different doses (200 and 400 mg/kg body weight) of the methanol extract. At the dose of 400 mg/k...

Hemayet Hossain*, Abdullah Al-Mansur , Sanjida Akter , Umme Sara , Md. Ranzu Ahmed and Abu Anis Jahangir

Senior Scientific Officer, Chemical Research Division, BCSIR Laboratories, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1246-52

1246-1252

2514

707

17.

STABILITY-INDICATING SPECTROFLUORIMETRIC DETERMINATION OF NALBUPHINE HYDROCHLORIDE IN RAW MATERIAL AND PHARMACEUTICAL PREPARATION

A Simple, rapid, sensitive, accurate and precise spectrofluorimetric method has been developed for selective determination of nalbuphine hydrochloride (NAL) in presence of its oxidative degradate in bulk powder and in pharmaceutical preparation. The proposed method is based on measuring the native fluorescence of NAL in acetonitrile at 337 nm after excitation at 285 nm. All variables that affect f...

Khalid A. Attia, Mohammed W. Nassar and Ahmed El-Olemy Allam*

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1252-58

1253-1258

1718

442

18.

EVALUATION OF DIURETIC ACTIVITY FROM TEUCRIUM POLIUM L. CAPITATUM EXTRACTS (LAMIACEAE) IN RATS

The present study was carried out to investigate the diuretic activity of the ethanolic extract of Teucrium polium L. Capitatum (Lamiaceae)in normal albino rats. The diuretic activity of extract was evaluated by determining the urine volume and electrolyte concentration in albino rats (n=4). Furosemide (20 mg/kg) was used as the reference diuretic drug while normal saline (0.9%) was used as contro...

S. Malki* and A.L. Yahia

Department of Biology, Faculty of Science, Larbi Ben M’hidi University, Oum El Bouaghi 04000, Algeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1259-62

1259-1262

1742

462

19.

USE OF COMPLEMENTARY AND ALTERNATIVE MEDICINE IN THE POPULATION OF KEDAH DARUL AMAN, MALAYSIA

Aim: To determine the use of Complementary and Alternate Medicine (CAM) for health issues and health maintenance among the population of Kedah state, Malaysia. Method: A questionnaire based cross-sectional survey was conducted for a period of three months in Kedah state, Malaysia. The questionnaire was prepared in English and Bahasa Malaysia and distributed to the randomly selected participants...

Shalini Sivadasan, Abdul Nazer Ali*, Looi Wan Lin, Daveena Balakrishnan, Shamala Ramachandran, Sockalingam Arumugam Dhanaraj

Faculty of Pharmacy, AIMST University, Semeling - 08100, Bedong, Kedah Darul Aman, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1263-73

1263-1273

1923

599

20.

PATIENT- REPORTED ADVERSE EFFECTS TO ANTI RETROVIRAL DRUGS IN A SPECIALIST HOSPITAL, NORTH WEST NIGERIA

Patients experiencing adverse effects are less likely than those not experiencing it to adhere to treatment. However little is known about the adverse drug reactions to many HIV programme in developing countries, indicating the need for Antiretroviral (ART) safety surveillance. The study is a retrospective analysis of records of adverse reactions by patients initiated on ART. A total of 1870 patie...

I.M. Adebisi*, A.O. Jimoh , E.G. Odoh , A.S. Adebisi 3 S. B. Shittu and Z. Sani

Lecturer II, Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1274-78

1274-1278

1694

500

21.

ANTIMICROBIAL ACTIVITY OF SUPERCRITICAL CARBON DIOXIDE EXTRACTS OF TUBEROSE (POLIANTHES TUBEROSA LINN.) FLOWERS AGAINST COMMON PATHOGENS

Tuberose flower extracts were obtained by green technology of Supercritical carbon dioxide (SC-CO2) extraction and solvent extractions (using n-hexane and petroleum ether of b.p. 60-80 °C). Antimicrobial activities of these extracts were tested in vitro against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Helicobacter pylori, Vibrio cholerae and Candida albicans. No activity w...

Probir Kumar Ghosh , Paramita Bhattacharjee* and Satadal Das

Assistant Professor, Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata 700032, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1279-89

1279-1289

2084

1282

22.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF HYDRALAZINE, ISOSORBIDE DINITRATE IN BULK AND TABLET FORMULATION BY RP-HPLC

A simple, sensitive, linear, precise and accurate RP-HPLC method for simultaneous estimation of Hydralazine, Isosorbide dinitrate in bulk and tablet formulation was developed and validated. The chromatographic separation of the three drugs was achieved on Zodiac C18 (250 mm ´ 4.6 mm) 5µ column in an isocratic mode. The mobile phase consisting of 0.01M 0.01 M Ammonium acetate : Acetonitrile : Met...

K. Neelima* and Y. Rajendra Prasad

Department of Chemistry, Sarojini Naidu Vanitha Pharmacy Mahavidyalaya, Exhibiton grounds, Nampally, Hyderabad-500001, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1290-94

1290-1294

2863

1010

23.

DESIGN AND EVALUATION OF BILAYERED MUCOADHESIVE FILM OF CEFPODOXIME PROXETIL

The objective of the present work was to formulate and evaluate a sustained release gastroretentive dosage form. A mucoadhesive bilayered film was prepared consisting of an Immediate Release (IR) and a Controlled Release (CR) layer. The film is folded into a Hard Gelatin Capsule which after administration into GIT unfolds and adheres to the GI mucosa. Cefpodoxime Proxetil is an antibiotic of BCS C...

N. Banerjee and S.R. Singh

Dr. L.H. Hiranandani College of Pharmacy, Ulhasnagar-03, Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1295-02

1295-1302

1889

718

24.

EVALUATION OF EFFECTS OF PARTHENIUM HYSTEROPHORUS L., LEAVES EXTRACTS AGAINST MILK-INDUCED EOSINOPHILIA IN MICE

Parthenium hysterophorus L., compositae, also known as congress weed, carrot weed, star weed, reaching a height of 2 m in  weeks of germination, is believed to have entered India accidentally in the mid 1950's and is now available abundantly all over the India. Leaves are traditionally used in the treatment of asthma and allergy, leavas of the plant were extracted successively using aqueous and...

S. Rajasekaran

Department of Pharmacology, Jamia Salafiya Pharmacy College, Pulikkal, malappuram, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1303-06

1303-1306

1834

612

25.

ENHANCEMENT OF DISSOLUTION OF CLOPIDOGREL MINI-TABLETS IN INTESTINAL FLUIDS WITH THE AID OF IN-SITU ACIDIFYING AGENT

The main objective of the present study is to enhance the dissolution of clopidogrel bisulphate in intestinal fluids by formulating into mini-tablets with in-situ acidifying agent mini-tablets. The solubility data reveals, Clopidogrel bisulphate is freely soluble in pH 2.0 and the solubility decreases with increase in pH. Whereas, with weak acid, the solubility of clopidogrel is increased at pH 5....

R. Subburayalu *, J. Kunchithapatham, R. Pillappan and T. Devi

Department of Pharmacy, Annamalai University , Annamalai Nagar, Chidambaram, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1307-14

1307-1314

2725

1428

26.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF CHOLINE FENOFIBRATE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM

A simple and precise RP-HPLC method was developed and validated for the determination of Choline fenofibrate in pharmaceutical dosage forms. Chromatography was carried out on Agilent make Zorbax C18 column (4.6 mm x 15 cm), 5 µ particle size using a mobile phase of phosphate buffer (pH 6.8) : acetonitrile (70 : 30 % v/v) at a flow rate of 0.8 ml/min. The analyte was monitored using UV detector at...

G. Saravanan*, Md. Yunoos, A. Naveen Kumar and P. Pradeep Kumar

Department of Pharmaceutical Analysis, Bapatla College of Pharmacy, Bapatla - 522101, Guntur (Dt), Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4). 1315-19

1315-1319

2153

738

27.

ESTIMATION OF FLAVONOID, PHENOL CONTENT AND ANTIOXIDANT POTENTIAL OF INDIAN SCREW TREE (HELICTERES ISORA L.)

Helicteres isora (L.), a South-Asian plant, is a rich source of medicinal and antioxidant compounds and has been widely used in traditional medicine. Antioxidants are important to neutralize damaging free radicals in the body, especially when the systemic defence mechanisms prove insufficient. The objective of this study was to determine the antioxidant potential of its fresh and dry plant parts i...

Amita Jain *, Prakriti Sinha and Neetin S. Desai

Department of Biotechnology and Bioinformatics, Padmashree Dr. D.Y. Patil University, Sector No-15, CBD, Belapur, Navi Mumbai - 400 614, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1320-30

1320-1330

2730

793

28.

FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF DICYCLOMINE HYDROCHLORIDE BY USING HYDROPHILIC POLYMERS

The objective of the present study was to develop Sustained release matrix tablets of Dicyclomine hydrochloride to reduce the dosing frequency to twice daily thereby increasing patient compliance and therapeutic efficacy. Twelve batches of tablets were fabricated using hydrophilic polymer guar gum alone or in combination with xanthan gum and pectin. All the batches were formulated by wet granulati...

Kiran Joshi *, Shashikant Dhole and Anjali Doltode

Department of Pharmaceutics, Modern College of Pharmacy (for Ladies), Moshi, Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1331-38

1331-1338

2566

674

29.

FORMULATION AND EVALUATION OF STIMULI SENSITIVE pH TRIGGERED IN-SITU GELLING SYSTEM OF FLUCONAZOLE IN OCULAR DRUG DELIVERY

The present research finding focuses with the formulation and development of in situ gelling system of fluconazole using stimuli sensitive hydrogels. The quick elimination of the drug in the pre-corneal region thereby reducing the bioavailability of conventional ophthalmic solutions may overcome by means of in situ gel forming systems.  These are instilled as drops into the eye and undergo a sol-...

S. Nagalakshmi*, Seshank, Radhika Ramaswamy and S. Shanmuganathan

Department of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai-116, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1339-44

1339-1344

1986

684

30.

GQSAR APPROACH TO STUDY THE EFFECT OF VARIOUS GROUPS ON SUBSTITUTED QUINOLINES SHOWING ANTI-TUBERCULOSIS ACTIVITY

In this paper, an attempt was made to develop a Group-Quantitative Structure Activity Relationship (GQSAR) model on a series of substituted Quinoline derivatives as anti-Tubercular agents. The dataset was fragmented based on substitution points on the quinolone ring. Various 2D descriptors were calculated and used in the present analysis. For model validation, the dataset was divided into various ...

B.J. Mylliemngap , A. Borthakur , K. Ingale , S. Karanam , D. Velmurugan , A. Bhattacharjee*

Department of Biotechnology and Bioinformatics, North Eastern Hill University, Shillong-793022, Meghalaya, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1345-51

1345-1351

1704

519

31.

DESIGN AND EVALUATION OF METHOTREXATE LOADED MULTILAYERED TABLET FORMULATION FOR TREATMENT OF COLON CANCER

The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. The aim of the present research work was to develop sustained release multi-layered formulation of Methotr...

Jaideep Bhardwaj* and Sayantan Mukhopadhyay

Department of Pharmacy, GRD (PG) IMT, 214 Rajpur Rd., Dehradun -248009, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1352-61

1352-1361

2886

578

32.

CUTANEOUS LEISHMANIASIS IN SYRIA

Cutaneous leishmaniasis (CL) is a public health problem in Syria call for this parasite’s epidemiological and evolutionary investigation. Evaluation of its population structure by multilocus enzyme electrophoresis (MLEE), current gold standard for classification, has some drawbacks ,such as the lack of discriminatory power below species level, it is labour intensive and  time-consuming. In this...

Idriss Sara*, Abdulkader Rahmo and Mohammad Maarouf

Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1362-66

1362-1366

1754

565

33.

FORMULATION AND EVALUATION OF OCULAR NIOSOMAL IN SITU GELS OF LINEZOLID

Niosomes, an emerging class of novel vesicular systems, are non-ionic surfactant vesicles which can entrap both hydrophilic and lipophilic drugs. Niosomes are incorporated into in situ gels for sustained release of drug and to prolong the residence time. The aim of present study is to formulate and evaluate ocular niosomal in situ gels of Linezolid. Linezolid is a potent synthetic oxazolidinone de...

B. Lavanya, S. Indira* and Prathima Srinivas

Department of Pharmaceutics, Sri Venkateshwara College of Pharmacy, Osmania University, Madhapur, Hyderabad-500081, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1367-75

1367-1375

2505

1106

34.

MOLECULAR DOCKING STUDIES OF BMS-378806 ANALOGS AS NOVEL HIV-1 GP120/CD4 INHIBITORS

AIDS, a pandemic disease caused by HIV has a high mortality rate. Therapeutic failures have risen due to the emergence of resistant viral strains and adverse side-effects of Anti-HIV drugs. Thus, there arises a need to develop novel and promising anti-HIV drugs. BMS-378806 (BMS-806) inhibits the initial stages of HIV-1 infection by blocking the binding of viral gp120 protein to host-cell CD4 recep...

Sandhya Vijayasarathy

Department of Biotechnology, PES Institute of Technology, Bangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1376-80

1376-1380

1770

570

35.

SENSITIVE, HIGH-THROUGHPUT AND ENANTIOSELECTIVE QUANTITATION OF ZOPICLONE IN HUMAN PLASMA BY LCMS/MS: APPLICATION TO A HUMAN PHARMACOKINETIC STUDY

Zopiclone (ZPC), a cyclopyrrolone derivative, is a short-acting hypnotic agent. Its pharmacological properties include hypnotic, sedative, anxiolytic, anticonvulsant and muscle-relaxant actions. ZPC has a single chiral centre, and its enantiomers are S-zopiclone (S-ZPC) and R-zopiclone (R-ZPC). S-ZPC was adjudge to possess two- fold enhanced pharmacological activity than racemate (ZPC) while its o...

Aslam Khan*, M. Rajput, A. Sen, P. Sinha Ray, S. Biswas, A. Khan and A. More

Clinical Research Services, Reliance Life Sciences Private Limited, Dhirubhai Ambani Life Sciences Centre (DALC), Thane-Belapur Road, Rabale, Navi Mumbai-400 701, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1381-94

1381-1394

2027

1162

36.

DEVELOPMENT AND EVALUATION OF SOME MICROSPONGE LOADED MEDICATED TOPICAL FORMULATIONS OF ACYCLOVIR

Skin has to bear various external traumas like wounds, burns, blisters, irritation etc. as well as topical diseases like psoriasis, vitilago, cancer and herpes. Various drug delivery systems like vesicles, microspheres, transdermal patches, nanoemulsions, microemulsions, microsponges etc. are available which are better than conventional drug delivery methods because these bypass systemic circulati...

P. Yadav and S. Nanda*

Department of Pharmaceutical Sciences, M.D. University Rohtak-124001, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1395-10

1395-1410

3878

1739

37.

EVALUATION OF DIURETIC EFFECT OF LYCIUM BARBARUM LINN. (GOJI BERRY) IN RATS

Wolf berries or Goji berries (Lycium barbarum L. Solanaceae) have a long tradition as food and medicinal plant. The bark of Goji berries is generally harvested in the winter season and then dried to be used for diuretic purposes. Hence, this study was designed to evaluate the possible diuretic effects of powdered L. barbarum. The study was conducted in saline primed Wistar albino rats (n=6) using ...

Preethi G. Pai*, Umma Habeeba, K. Ramya, M.S. Pradeepthi and Yogesh Belagali

Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal University, Mangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1411-15

1411-1415

2579

608

38.

STUDIES ON ALLERGENS CAUSING BRONCHIAL ASTHMA AND ALLERGIC RHINITIS

The studies on allergen causing bronchial asthma and allergic rhinitis were done by testing Immunoglobulin E level and absolute Eosinophil count to clinical patients in JEBI laboratory. The patients were from urban and rural areas, comprising both males and females in all age groups.  Out of 613 patients, 523 patients were having markedly increased IgE level and 147 patients were found increased ...

S. Manohar*, K. Sivanandhan , A. Michael and R. Selvakumaran

Ph. D Scholar, JEBI Laboratory, Karpagam University, B.G. Puram Street, Pollachi, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1416-23

1416-1423

1687

541

39.

HYPER ACCUMULATION OF CADMIUM IN SOLANUM NIGRUM L. AND THEIR EFFECTS ON PHYTO-CHEMICALS AND ANTIOXIDANT ENZYMATIC ACTIVITIES

In the pot experiment, Solanum nigrum L. treated with different concentration of Cd showed high accumulation of Cd in plant. Growth of plant was not significantly affected up to ≤ 50ppm Cd treated plant, The trends of Cd accumulation in plant were leaf>shoot>root with increasing concentration of Cd and DAS. Plant accumulates 298, 92 and 58 ppm of Cd after 60DAS in leaf>shoot>root re...

G.K. Dwivedi*, S.K. Upadhyay , A.K. Mishra and Arvind Kumar Singh

Department of Botany, T.D.P.G. College, Jaunpur-222001, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1424-30

1424-1430

1793

640

40.

SUPPRESSION OF ELEVATED REACTIVE OXYGEN SPECIES BY ACORUS CALAMUS (VACHA) A SWEET FLAG IN DROSOPHILA MELANOGASTER UNDER STRESS FULL CONDITIONS

Reactive Oxygen Species is a phrase used to describe a number of reactive molecules and free radicals derived from molecular Oxygen. The production of Oxygen based radicals is the bane to all aerobic species where its excessive levels intern induces oxidative stress. The present study is to evaluate the anti-stress property of Acorus calamus (vacha), where the fruit flies in different groups are a...

Asra Fathima, H.B. Vasanth Patil and B.Y. Sathish Kumar*

Post Graduate Department of Studies and Research in Bio-technology, J.S.S. College of Arts, Commerce and Science (Autonomous college of University of Mysore), Ooty Road, Mysore 570 025, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1431-39

1431-1439

1546

603

41.

FORMULATION AND EVALUATION OF FLOATING TABLET OF METOPROLOL SUCCINATE WITH SYNTHETIC SUPERDISINTEGRANT

The present work was designed to formulate floating tablet of Metoprolol Succinate with synthetic superdisintegrant as swelling agent. Various formulations of Metoprolol Succinate were prepared by direct compression method using the different concentrations of superdisintegrant ranging from 10% to 15%. The selected batches were evaluated for various parameter like weight variation, thickness, diam...

Pankaj Kumar Yadav* and Himansu Chopra

Faculty of Pharmacy, GRD (PG) IMT, 214-Rajpur Road, Dehradun, 248009, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1440-48

1440-1448

2848

624

42.

COMPARATIVE POWDER MICROSCOPICAL SCREENING OF THE RHIZOME AND LEAF OF ALPINIA CALCARATA AND ALPINIA GALANGA

The therapeutic use of herbal medicine has gained considerable momentum in the world during the past decade. Hence, Quality control standards for various medicinal plants used in indigenous systems of medicine are becoming more necessary. Adulteration and misidentification of medicinal plants can cause serious health problems to consumers and pose legal problems for pharmaceutical firms. So, the a...

Silvy Mathew*, S. John Britto and Sinjumol Thomas

The Rapinat Herbarium and Centre for Molecular Systematics, St. Joseph’s College (Autonomous), Tiruchirappalli- 620 002, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1449-53

1449-1453

2146

757

43.

ISOLATION AND IDENTIFICATION OF THE FLAVONOID “QUERCETIN” FROM TRIDAX PROCUMBENS LINN.

Tridax procumbens (Linn.) is an important medicinal plant belonging to the family Asteraceae. It is known for a number of pharmacological activities like antidiabetic, anticancer, anti-inflammatory, wound healing, hepatoprotective and antioxidant activity.Flavonoid “Quercetin” was isolated from the flowers of this plant. Dried flowers were Soxhlet with petroleum ether, chloroform, and methanol...

Nikita Sanghavi, Rashmi Srivastava and Yashwant Malode*

MET Institute of Pharmacy, Bhujbal Knowledge Center, MET Complex, Bandra (W), Mumbai 400050, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1454-59

1454-1459

4984

1143

44.

EVALUATION OF ANTIMICROBIAL ACTIVITY OF DIFFERENT HERBAL PLANT EXTRACTS

This work has been undertaken to study the antimicrobial efficiency of Hexane, Ethyl acetate, Ethanolic extracts of herbal plants (Anthocephalus cadamba, Allium sativum, Origanum vulgare, Ocimum sanctum) against human pathogens like Staphylococcus aureus (MTCC-3160), Escherichia coli (MTCC-1652) and fungi Aspergillus niger (MTCC-282) by using agar well diffusion method. All the plants showed signi...

T. Rajesh*, E. Venkatanagaraju , Divakar Goli and Syed Jalaluddin Basha

Department of Industrial Pharmacy, Acharya & B.M. Reddy College of Pharmacy, Soldevanahalli, Hesaraghatta, Bengaluru-560107, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1460-68

1460-1468

3870

745

45.

NEW SIMPLE RP-HPLC METHOD FOR THE ESTIMATION OF SILDENAFIL CITRATE IN PHARMACEUTICAL DOSAGE FORM

A new simple, rapid, accurate, precise and sensitive RP-HPLC method was developed for the estimation of sildenafil citrate in bulk and pharmaceutical dosage form. The separation of sildenafil citrate was achieved on a Phenomenex C18 Column (150 X 4.6 mm i.d, 5µ particle size) with a mobile phase consisting of methanol and Buffer (50:50 % v/v). The flow rate was 1.5 ml/min and photodiode array det...

T. Sivakkumar* and P. Giriraj

Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar- 608 002, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1469-73

1469-1473

2057

615

46.

DESIGN AND FORMULATION OF NOVEL PHARMACEUTICAL CAPSULES OF HERBAL ORIGIN FOR DIABETES MELLITUS

Onion, garlic and fenugreek are widely cultivated in Egypt and many reports confirmed their antidiabetic activities as used separately. Current study focused on these three herbs when present together in a mixture. All dried herbs were finely powdered to obtain homogenous mixtures. Pre-formulation studies were conducted on each individual herb including determination of foreign matter, loss on dry...

U. Farghaly*, M. S. Kamel A. H. Elzahwey and S. A. Mangoura

Faculty of Pharmacy, El-Minia University, El-Minia, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1474-81

1474-1481

2300

597

47.

SYNTHESIS OF NOVEL HESPERETIN OXIME ESTERS: A NEW DISCERNMENT IN TO THEIR ANTIOXIDANT POTENTIAL

A series of novel hesperetin oxime esters (3a-l) were synthesized and there in vitro antioxidant potential was examined.  Hesperetin oxime 2 was furnished by oximation of hesperetin then subsequently upon esterification with substituted benzoyl chlorides to obtain hesperetin oxime esters (3a-l) in good yields. The structure of compounds was elucidated by elemental analysis, IR, NMR (1H, 13C) and ...

Nagaraja Naik* and Salakatte Thammaiah Harini

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1482-89

1482-1489

1780

607

48.

BIOLOGICAL STUDY TO ASSES HEALTH OF NARMADA RIVER IN JABALPUR

Present studies was undertaken to find out of aquatic fungi in river Narmada. Fungi are eukaryotic, heterotrophic organisms, including both single-celled yeasts and multi-cellular filamentous fungi. Many fungal species can survive in oligotrophic environments, through scavenging nutrients from the substrate which they colonies, or the air or water in which they live. Fungi also produce secondary m...

Jaya Singh, Saurabh Gupta, and Jayram Tiwari

Research Institute, Biodiversity Conservation & Rural Biotechnology Centre, Jabalpur, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1490-92

1490-1492

2148

565

49.

IN SILICO CHARACTERIZATION OF GlmU ANTIGENIC MYCOBACTERIUM TUBERCULOSIS PROTEIN

Tuberculosis (TB) is a disease caused by a bacterium called Mycobacterium tuberculosis. The bacteria usually attack the lungs. Tuberculosis is a global health threat and infecting about one third of the human population. Despite having a variety of anti-tuberculous drugs and availability of effective chemotherapy and Bacille-Calmette –Guerin (BCG) vaccine, tuberculosis remains a leading infect...

Mubashshira A. Pathan*, Aasma S. Jamkhandi and Anil Kumar S Katti

Department of P.G. Studies in Bioinformatics, Walchand Centre for Biotechnology, Walchand College of Arts and Science, Solapur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1493-99

1493-1499

1611

582

50.

TREATMENT OUTCOMES OF TUBERCULOSIS PATIENTS IN DEBRE MARKOS REFERRAL HOSPITAL, NORTH WEST ETHIOPIA (JUNE 2008-AUGUST 2013): A FIVE YEAR RETROSPECTIVE STUDY

Background:Tuberculosis is the second most common cause of death due to an infectious disease after human immunodeficiency virus. According to World Health Organization 2010 report, 9.4 million incidents and 14 million prevalent cases were occurred. Ethiopia has been one of the 22 high TB burden countrieswith an incidence and prevalence rate of 300 and 470 cases per 100,000 populations respective...

Ahmed Esmael*, Girma Tsegaye , Moges Wubie , Habtamu Abera and Mengistu Endris

Department of Microbiology, Immunology & Parasitology, College of Health Sciences, Debre Markos University, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1500-05

1500-1505

2164

560

51.

HEPATOPROTECTIVE ACTIVITY OF METHANOL EXTRACT OF FENUGREEK SEEDS ON RATS

The present study was conducted to evaluate the hepato-protective activity of methanol extract of seeds of Trigonella foenum graecum (TFG)in CCl4 induced toxicity in Wistar albino rats. Seeds of TFG were collected, and subjected to continuous cold maceration in a macerator, for 72 h with solvents like petroleum ether (60 – 80) and methanol separately. Hepatic injury in rats was induced separatel...

Shaileyee Das

Department of Pharmaceutical Chemistry, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus Kolkata group of Institution, Kolkata-700053, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1506-13

1506-1513

2263

766

52.

ANTITUMOR ACTIVITY OF MIMOSA RUBICAULIS LAM AGAINST EHRLICH ASCITES CARCINOMA IN SWISS ALBINO MICE

The antitumor activity of the methanol stem extract of Mimosa rubicaulis lam (MEMR) was evaluatedagainst Ehrlich Ascites Carcinoma (EAC) tumor model in Swiss albino mice. After 24h of intraperitonial inoculation of tumor (EAC) cells in mice, MEMRwas administered at the dose of 100, 200 and 400mg per kg body weight orally for 13 consecutive days. After 24 h of the last dose and followed by eighteen...

M.N. Chowdary Nandipati*, G. Sumalatha , Ch. Baburao , J. Ramesh Babu and C. Sridevi

Department of Pharmacology, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1514-24

1514-1524

12478

612

53.

WHAT SUITS BEST FOR ORGAN WEIGHT ANALYSIS: REVIEW OF RELATIONSHIP BETWEEN ORGAN WEIGHT AND BODY / BRAIN WEIGHT FOR RODENT TOXICITY STUDIES

Organ weight analysis is an important endpoint for identification of potentially harmful effects of test compounds in toxicology studies. Organ weight differences are often accompanied by differences in body weights between treatment groups which make the organ weight interpretation more difficult. We have evaluated the relationship between organ weight and body/brain weight based on statistical a...

Ramakrishna Nirogi, Vinod Kumar Goyal*, Santanu Jana, Santosh Kumar Pandey and Anil Gothi

Discovery Toxicology, Suven Life Sciences Ltd., Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1525-32

1525-1532

4903

925

54.

FORMULATION AND EVALUATION OF GASTRORETENTIVE DELIVERY OF TIZANIDINE HYDROCHLORIDE USING NATURAL POLYMERS

The present investigation concerns the design and evaluation of floating tablets of Tizanidine hydrochloride, which after oral administration are designed to prolong the gastric residence time and increased drug bioavailability. It is a centrally acting α2 adrenergic agonist. It is used in the treatment of migraine headaches, spasms and anticonvulsant. The dosage was designed by using natural pol...

http://ijpsr.com/wp-content/uploads/2014/09/54-Vol.-5-Issue-4-April-2014-IJPSR-RA-3230-Paper-54.pdf

Vignan Pharmacy College, Guntur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1533-38

1533-1538

2107

731

55.

KNOWLEDGE ON MEDICATION TAKING BEHAVIOUR, BALANCED DIET AND PHYSICAL ACTIVITY – A SURVEY AMONG THE ADOLESCENTS

ABSTRACT: The main objective of the study is to promote awareness and assess the knowledge of adolescents on medication use, importance of balanced diet and physical activity. The study was conducted among the adolescents’ aged from16-18 years in regions of Guntur. The volunteers are allowed to fill their informed consent to be a part of the study. The questionnaire was distributed to all the vo...

Mounika S*, Raghuram V , Chaitanya Lakshmi CH, Rama Rao N

Pharm D, Department of Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1539-43

1539-1543

1683

580

56.

ANALYSIS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY OF IBUPROFEN TABLET

A rapid and sensitive method for the determination of the best conditions that allow us to calibrate the ibuprofen in drug is presented. This approach uses high performance liquid chromatography with DAD detector, which is a separation method most used because it is fast, easy, and maintains the nature of the mixture to be separated.    The spectra of ibuprofen were recorded using several mobil...

Zohra Chakrar , Rachid Fegas *, Said Zerkout, Zhor Bettache and Abdalhamid Zerdaoui

Laboratory of Bioactive Products Research and Promotion of Biomass (LPBVB), Ecole Normale Supérieur - KOUBA / Algiers - Algeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1544-49

1544-1549

2283

688

57.

IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF CANDESARTAN CILEXETIL BY SOLID DISPERSION IN POLYVINYL PYRROLIDONE

The aim of the present study was to characterize solid dispersion (SD) of Candesartan cilexetil (CC) prepared with polyvinyl pyrrolidone K30 (PVP) for enhancing its solubility and bioavailability. The SDs of Candesartan was prepared by solvent evaporation method. The prepared SDs were evaluated for saturation solubility, practical yield, drug content, and in vitro dissolution study, IR-Spectroscop...

Vishal S. Katti, Atul M. Kadam*, Sandip M. Honmane, Shitalkumar Patil, Sachin Patil and Kiran Bhamare

Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth-Vadgaon, Kolhapur– 416112, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1550-56

1550-1556

2827

753

58.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME TARTARATES AND TRANSITION METAL COMPLEXES

Metal complexes having two or more different metal ions not only possess excellent catalytic applications but also have many biological activities. In the present work, some ligand tartarate based mixed transition metal complexes of type [MxMI1-x (C4H4O6)]. XH2O [Where M and MI are Cu and Ni, and x= 0.2, 0.4, 0.6 and 0.8] have been successfully synthesized and were characterized by different sophi...

S.S. Pawar , C.S. Patil , V.B. Tadke , S.M. Vhankate , S.A. Dhanmane , G.R. Pathade and R.P. Pawar*

Department of Chemistry, Deogiri College, Aurangabad, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1557-65

1557-1565

1886

569

59.

SIMULTANEOUS ESTIMATION OF CEFPODOXIME PROXETIL AND POTASSIUM CLAVULANATE IN TABLET FORMULATION BY RP-HPLC

A new Reversed Phase-High Performance Liquid Chromatographic method was developed and validated for the quantitation of Cefpodoxime proxetil (Cef) and Potassium clavulanate (Pot. clav.)  in pharmaceutical formulations. Determination was performed using a Hypersil-BDS (C-18) column (5 μm, 250 mm   4.60 mm), a mobile phase containing phosphate buffer (5.5 pH): acetonitrile (51:49 v/v), in iso...

Shweta B. Dighe

Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-18, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1566-71

1466-1571

2404

574

60.

PHYTOCHEMICAL SCREENING AND ANTIOXIDANT POTENTIAL OF ROOT OF MENTHA ARVENSIS L. FROM KASHMIR REGION

To evaluate phytochemical constituents and antioxidant potential of aqueous and hydroalcoholic extracts of root of Mentha arvensis L from Kashmir region. The antioxidant activity of aqueous and hydroalcoholic extracts of Mentha arvensis L was evaluated by using 1, 1-diphenyl, 2-picrylhydrazyl (DPPH) scavenging, reducing power, metal chelating, hydrogen peroxide scavenging  and nitrous oxide scave...

M.A. Dar, M.H. Masoodi* and M. A. Mir

Department of Pharmaceutical Sciences, University of Kashmir, Srinagar-190006, Jammu & Kashmir, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1572-80

1572-1580

2029

624

61.

COMPARATIVE STUDY OF THREE DIFFERENT APPROACHES USED FOR MANUFACTURING OF ANTIDIABETIC ORODISPERSIBLE TABLETS

Diabetes mellitus basically a chronic metabolic disorder that results in boosting up blood glucose level to higher concentrations. It is associated with bunch of diseases. To overcome patient’s common problems i.e. throat pain, vomiting, non-compliance, inconvenience and ineffective therapy plan or to enhance patient compliance and effectiveness of therapy scientists have launched orodispersible...

Asif Mahmood*, Rai Muhammad Sarfraz , Muhammad Zaman , Haseeb Ahsan, Muhammad Ahsan Hafiz and Muhammad Abdullah Akram

Faculty of Pharmacy, University of Sargodha, Sargodha, 40100, Punjab, Pakistan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1581-88

1581-1588

2261

473