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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 5 (2014) - Issue 12, December

Review Articles

 
Title
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1.

AMBULATORY BLOOD PRESSURE MONITORING: A NON-INVASIVE GOLD STANDARD FOR HYPERTENSIVE THERAPY

Blood pressure (BP) is one of the major prognostic indicators in cardiovascular patients and in patients with chronic kidney disease (CKD). Accurate measurement of BP is important to classify an individual to confirm BP related risk and to continue treatment. The limitations of conventional technique can be surpassed by ambulatory blood pressure monitoring (ABPM). ABPM strengthens its superiority ...

P. Lakshmi Sirisha, G. Kishore Babu *, P. Srinivasa Babu and P. Koteswari

Department of pharmaceutics, Vignan Pharmacy College, Vadlamudi, A.P. India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5073-87

5073-5087

2923

823

2.

A REVIEW ON AYURVEDIC MEDICINAL PLANTS FOR EYE DISORDERS FROM ANCIENT TO MODERN ERA

The management of eye disorders by chemical drugs without any side effects is still a challenge to the medical system. But the herbal medicines have potential to overcome the limitations associated with conventional drugs. Therefore; many efforts have been made to identify new medicinal plants from different sources because of their effectiveness, fewer side effects and relatively low cost. Approx...

Pooja*, V.K. Lal and A.Verma

School of Pharmaceutical Sciences, IFTM University, Moradabad, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5088-96

5088-5096

8693

2328

3.

IMPORTANCE OF FLUOROQUINOLONES IN HUMAN HEALTHCARE: A COMPREHENSIVE REVIEW

Fluoroquinoloes are a very important group of antibacterial agents that are widely prescribed for the treatment of infectious diseases in humans. These agents have excellent bioavailability and good tissue penetration with antimicrobial   activity against pathogens especially resistance to other class of antimicrobial drugs. This article gives a comprehensive review on different aspects of fluor...

Girish M. Bhopale

Dr. D. Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Tathawade, Pune, 411033, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5097-03

5097-5103

2938

850

4.

MIMOSA PUDICA LINN- A SHYNESS PRINCESS: A REVIEW OF ITS PLANT MOVEMENT, ACTIVE CONSTITUENTS, USES AND PHARMACOLOGICAL ACTIVITY

To cure all aliments of mankind, nature provides a complete store house of remedies for time honored period.In legume family, Mimosa   is one of the largest genera which distribute more than 500 species. This article aims to provide a comprehensive review on plant movement, chemical constituents, pharmacological activities and uses on Mimosa pudica, sensitive plant. Its habitat are lowland tropi...

Kshema Johnson, Gopinathan Narasimhan* and Chitra Krishnan

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sri Ramachandra University, Chennai, Tamilnadu - 600116, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5104-18

5104-5118

11952

2927

5.

LIQUISOLID TECHNIQUE: A NOVEL APPROACH FOR SOLUBILITY ENHANCEMENT

Liquisolid Technique is one of the novel approach for drug delivery system for oral route. Bioavailability of any drug is mainly dependent upon its dissolution rate and dissolution rate is dependent upon solubility of that drug. So, if any drug has less solubility then of course its bioavailability will be less. Hence there is need of enhancement of solubility of poorly soluble drugs for enhancing...

Devendra G. Kapadnis* and Anand D. Savakare

MVP Samaj’s College of Pharmacy, Nashik, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5119-26

5119-5126

2162

896

Research Articles

 
Title
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6.

EVALUATION OF HYDROXYPROPYLMETHYLCELLULOSE (HPMC) HYDROGEL MATRIX FOR DELIVERY OF TRIAMCINOLONE

The main purpose of this study was to evaluate hydrogel matrix systems of hydroxypropylmethylcellulose (HPMC) for oral release of poorly water-soluble drugs, by using triamcinolone (TR) as drug model. The influence of HPMC ratio (%) and compaction force (Kgf) on system performance were studied. Thus, several batches of tablets containing 10 mg of TR were prepared using distinct proportions of HPMC...

Vivian Vollet de Morais, Alice Rodrigues de Oliveira, Magda Rhayanny Assuncao Ferreira, Fabio Araujo Bezerra, Pedro Jose Rolim Neto, Tatiane Pereira de Souza, Arnobio Antonio da Silva Junior, Luiz Alberto Lira Soares

Laboratorio de Farmacognosia, Departamento de Ciencias Farmaceuticas, UFPE Av. Arthur de Sa, s/n, 50740-521, Recife, PE, Brazil.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5127-35

5127-5135

2357

722

7.

THE PROTECTIVE ROLE OF COLCHICINE ON DICLOFENAC SODIUM INDUCED HEPATORENAL TOXICITY IN ALBINO RATS MODEL

Diclofenac (DIC) is a widely used as an anti-inflammatory drug and it is used as the toxicant in hepatoprotective studies. In the present study, hepato-renal protective activity of Colchicine against DIC induced liver and kidney injury in albino rats was assessed. Animals were injected with Diclofenac sodium at the single dose of 150 mg/ kg body weight daily for 28 days. Oral administration of col...

Sylvia A. Boshra and Mohammed A. Hussein*

Biochemistry Department, Faculty of Pharmacy, October 6th University, 6th October city, Egypt.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5136-44

5136-5144

2202

683

8.

THE NON-ENZYMATIC ANTIOXIDANT ACTIVITIES OF FICUS CARICA L. SUBSP. CARICA LEAVES AND ITS ANTIMICROBIAL ACTIVITIES AGAINST FOOD PATHOGENS

The aim of this work was to investigate of the antimicrobial and antioxidant potentials of methanol extracts from Ficus carica. Methanol extracts were screened for antimicrobial activity against different species of Gram positive andGram negative bacteria and one yeast. The methanol extract of Ficus carica showed maximum inhibition zone of 10 mm against Listeria monocytogenes. In addition to, the ...

G. Okmen*, O. Turkcan, P. Erdal and D. Isik

Mugla Sitki Kocman University, Faculty of Science, Department of Biology, Mugla, Turkey.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5145-50

5145-5150

1611

752

9.

ACUTE AND SUBACUTE TOXICITIESOF THE AQUEOUS EXTRACT OF SIMAROUBA AMARA AUBLET STEM BARK

The decoction of Simarouba amara stem bark has been used to treat malaria, inflammation, diarrhea and as tonic. The aim of this study was to evaluate acute and subacute toxicities of the aqueous extract of S. amara stem bark (SAAE) in rats and mice, respectively. For the acute toxicity test, the SAAE was administered in a single oral dose of 2.0 g/kg (n = 5/group/sex) and in the subacute, the foll...

Helida M. L. Maranhao , Carlos F. B. de Vasconcelos , Larissa Araujo Rolim , Joao Henrique Costa-Silva , Jacinto da Costa Silva Neto and Almir Goncalves Wanderley

Associated Professor Departamento de Fisiologia e Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, s/n, CEP: 50670-901, Cidade Universitaria, Recife, PE, Brasil.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5151-62

5151-5162

2608

580

10.

ADEMETIONINE IN TREATMENT OF DRUG INDUCED LIVER INJURY: AN OBSERVATIONAL STUDY IN RUSSIAN PATIENTS, RECEIVING IMMUNOSUPPRESSIVE THERAPY FOR PSORIASIS

Background: Drug induced liver injury (DILI), especially; due to use of immunosuppressive agents is a growing concern. Lack of awareness about available treatment options limits its management. This observational study was conducted to characterize Russian population receiving ademetionine as a hepatoprotectant against DILI triggered due to immunosuppressive drugs. Methods: A total of 105 patients...

Y. Perlamutrov , A. Bakulev *, I. Korsunskaya, E. Orlov and N. Bolotnikova

Professor, Deputy Chief Physician for the Medical Work at Skin Diseases Clinic, Saratov State Medical University Provianskay st. 22, Saratov, 410028, Russia.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5163-69

5163-5169

2828

774

11.

ENHANCEMENT OF ARNICA MONTANA IN-VITRO SHOOT MULTIPLICATION AND SESQUITERPENE LACTONES PRODUCTION USING TEMPORARY IMMERSION SYSTEM

Arnica montana L. (Asteraceae) is a valuable medicinal plant species, endemic to Europe, which is threatened in many countries due to its overharvesting. The increasing market demand requires development of an effective method for A. montana rapid propagation, offering the possibility for its field cultivation as an alternative to plant gathering from nature. Three in -vitro culture systems were c...

M. Petrova *, E. Zayova , M. Todorova and M. Stanilova

Department of Applied Genetics and Plant Biotechnology, Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences Acad G. Bonchev Str. Bl. 21, 1113 Sofia, Bulgaria.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5170-76

5170-5176

1965

885

12.

CHEMICAL COMPOSITION OF ESSENTIAL OIL FROM LEAVES AND FLOWERS OF INULA VISCOSA (L.) IN AL-QADMOUS REGION, SYRIA

Leaves and flowers of Inula viscosa (L.) were collected from fields in Al-Qadmous, Syria. Essential oil was isolated by classical method of hydro distillation using the Clevenger-type apparatus. Its chemical composition was analyzed by GC/MS. The analysis led to the identification of48 and 43 components in flowers and leaves, respectively. Essential oils were characterized by a high content of oxy...

M. Nasser *, S. Housheh , A. Kourini and N. Maala

Faculty of pharmacy, Al-Andalus University for Medical Science. Department of Basic Sciences, Al-Qadmous, Syrian Arab Republic.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5177-82

5177-5182

2405

1082

13.

ELECTROCHEMICAL BEHAVIOUR OF OMEPRAZOLE INTERACTING WITH MYCIN DERIVATIVES AND DOXYCYCLINE

The interaction of omeprazole with different types of antibiotics was investigated in biological buffer at physiological pH=7.4 by using electrochemical (cyclic and linear sweep voltammetry) method. The reduction processes of omeprazole in the absence of and in the presence of azithromycin, clarithromycin, roxithromycin and doxycyclline are irreversible. Omeprazole interacts in solution with antib...

Mahmoud A. Ghandour*, Ahmed Hassan and Hazim M.Ali

Chemistry Department, Faculty of Science, Assiut University, 71516, Assiut, Egypt.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5183-90

5183-5190

2291

1115

14.

CHARACTERIZATION AND STANDARDIZATION OF THE HERBAL DRUG BACCHARIS TRIMERA (LESS.) DC AND ITS LYOPHILIZED EXTRACT

Baccharis trimera is used in traditional medicine in South American countries for treatment of diseases, such as digestive disturbances, rheumatism, diabetes and inflammatory processes. Given its pharmacological potential, the aim was to characterize the vegetal drug B. trimera and attain and standardize its lyophilized extract to use as raw vegetal material in the development of phytotherapeutic ...

P. A. Ferreira , F. L. A. Santos , L. D. S. Alves , L. R. M. Ferraz , T. A. Rosa , R. M. F. Silva , G. M. A. Presmich , Rolim, L. A. , M. S. Silva , M. B. S. Maia and P. J. Rolim-Neto *

Department of Pharmaceutical Sciences, Federal University of Pernambuco. Professor Arthur de Sa Street, s/n, Cidade Universitaria, 50740-521 Recife - PE, Brazil.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5191-00

5191-5200

1881

843

15.

SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR PROPERTIES PREDICTION OF 1, 3, 5-TRISUBSTITUTED 2-PYRAZOLINE DERIVATIVES

A number of trisubstituted 2-pyrazolines which are known for their biological importance like antimicrobial, anti-inflammatory, antitubercular, analgesic, anticancer, antimalarial, anti-viral, antihelmentic activities are prepared by reacting chalcones with phenyl hydrazine in absolute ethanol in presence of pyridine. In the present investigation an attempt has been made for the synthesis of 2-pyr...

Hemalatha Sattu *, B. Lakshmi and Rajendra Prasad

Associate professor, SNVPMV, Mukkaramjahi road, Nampally, Hyderabad, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5201-08

5201-5208

2026

1036

16.

GASTROPROTECTIVE POTENTIAL OF BIOACTIVE FRACTION FROM LASIA SPINOSA RHIZOME ON EXPERIMENTALLY INDUCED GASTRIC ULCERATION

Various parts of Lasia spinosa (Linn.) are widely used in North East region to manage wide range of disease but so for no scientific study was done to find out its pharmacological properties which may support its use in traditional medicine. Bioactive fraction (ethyl acetate fraction, LSE) from the methanol – water (80:20) extract of Lasia spinosa  rhizome was evaluated for gastroprotective and...

Mukesh K. Dubey *, Sanjib Das, Sanjay Yadav, Prakash Ch. Gupta, Sunil K. Jaiswal and Brijesh Sharma

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786004, Assam, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5209-15

5209-5215

2418

886

17.

QUORUM QUENCHING ABILITY OF DIETARY SPICE CINNAMOMUM VERUM ON PATHOGENIC BACTERIA

Quorum sensing is a bacterial cell communication mechanism mediated   through signal molecules such as AHL’s. Many opportunistic pathogens use these quorum sensing circuits to coordinate their virulence gene expression. Wide range of naturally occurring substances particularly   plant extracts have been evaluated for their ability to modulate quorum sensing in Gram-negative bacteria. Prelimi...

Y. Aparna *, Lalitha Narayanan and J. Sarada

Department of Microbiology, Bhavans Vivekananda College of Science, Humanities and Commerce, Sainikpuri, Secunderabad, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5216-23

5216-5223

2077

948

18.

COMPARATIVE SYNTHESIS AND PHYSICOCHEMICAL CHARACTERIZATION OF SUBSTITUTED 2-METHYLQUINOLIN- 4(1H)-ONE BY VARIOUS CONVENTIONAL AND MICROWAVE METHODS

In the present work various conventional methods and microwave method for synthesis of substituted quinolone reported. Substituted anilines were taken as a starting material and reacted with ethyl acetoacetate in presence of catalytic amount of acid and cyclized by various cyclisation agents that give the title compounds which differ in its color intensity, reaction time as well in %yield. Based o...

Harsha U. Patel and Piyush A. Gediya*

Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Arvind Baug, Mehsana-384001, Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5224-29

5224-5229

1662

993

19.

ABERRANT EXPRESSION OF WNT/BETA-CATENIN SIGNALING PATHWAY AND IN -VITRO CYTOTOXIC ACTIVITY OF TRADESCANTIA SPATHACEA MEDICINAL PLANT USED TO TREAT HUMAN BREAST ADENOCARCINOMA (MCF-7 CELL LINES)

Cancer plays crucial role in human life and critical disease to cure. Signaling pathways involved in stem cells development process. Especially, Wnt/β-catenin signaling pathway plays important role in stem cells self-renewal, differentiation and proliferation. Despite, over expression and mutation of Wnt/β-catenin signaling pathway induced variety of cancer development. Anticancer activities of ...

Rajendran Prakash * and Rattinam Rajesh

Research Student Department Of Biotechnology Vmkv Engineering College Vinayaka Missions University Salem, TN, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5230-34

5230-5234

1744

826

20.

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF NIGELLA SATIVA SEED OIL AND GINGER EXTRACT IN THE SAME DOSAGE FORM

The combination of Nigella sativa seed oil and ginger extract is used as antiulcer agent and to treat abdominal pain, diarrhoea and flatulence. The paper describes validated simultaneous equation method for the simultaneous estimation of Nigella sativa seed oil and Ginger extract in a combined dosage form. Nigella sativa seed oil and Ginger extract were found to have absorption maxima at 256 and 2...

B. Snehalatha*, M. Momin, A. V. Mishal and T. R. Kale

Quality Assurance Department, Oriental College of Pharmacy, Plot no.3,4,5; Sector-2, Near Sanpada Railway Station, Sanpada, Navi-Mumbai- 400705. India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5235-39

5235-5239

1792

1086

21.

PHYTOCHEMICAL AND ANTIOXIDANT STUDIES ON AN IMPORTANT INDIGENOUS MEDICINAL PLANT-ANDROGRAPHIS PANICULATA (BURM.F) NEES

Andrograhis paniculata is a wonder drug using in traditional systems of medicine for multiple clinical applications. This research article deals with the phytochemical and antioxidant properties of A. paniculata leaves.   Qualitative and quantitative phytochemical analyses were carried out by TLC and HPLC method.  Physico-chemical analysis was done to standardize the plant drug material so as t...

U. Umadevi and M. Kamalam

Department of Botany, PSGR Krishnammal College for Women, Coimbatore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5240-44

5240-5244

2464

1093

22.

PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF ROOT EXTRACT FROM ASPARAGUS RACEMOSUS L.

The present chemical analysis deals with Asparagus racemosus root for phytochemical screening and GC-MS analysis. Phytochemical constituent of the root extract was carried out according to the standard method. GC-MS analysis was performed on the methanolic extract of A. racemosus to find out the chemical constituents.  The phytochemical screening revealed the presence of flavonoids, alkaloids, st...

T. Sivakumar * and D. Gajalakshmi

Assistant Professor Department Of Botany Annamalai University, Annamalai Nagar-608002 Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5245-49

5245-5249

2701

1214

23.

DETECTION AND ISOLATION OF RESTRICTION ENDONUCLEASE LIKE TOPOISOMERASE FROM THERMOPHILIC BACILLUS SUBTILUS STRAIN RC1

Aims: Detection and isolation of restriction endonucleases like topoisomerase   Thermophilic Bacillus subtilus strain RC1. Methods and results: Topoisomerase like enzyme activity is detected from thermophilc Bacilus sp. The isolated enzyme is partially characterized. The molecular weight of the enzyme is ~ 33 KDa and the optimum temperature for the activity is 37 0C. The crude and gel purified e...

R.R. Chitte*, S.V. Deshmukh and P.P. Kanekar

Microbial Sciences Division, MACS-Agharkar Research Institute, Pune 411 004, Maharashtra, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5250-54

5250-5254

1967

663

24.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS DETERMINATION OF ZALTOPROFEN AND PARACETAMOL IN THEIR COMBINED SOLID DOSAGE FORM BYRP-HPLC METHOD

A simple, sensitive, linear, precise and accurate RP-HPLC method for simultaneous estimation of Zaltoprofen and Paracetamol in bulk and tablet formulation was developed and validated. The proposed RP-HPLC method utilizes Phenomenex C18 column (150 ×4.6 mm i.d., 5 µm), optimum mobile phase consisted of isocratic run of Phosphate buffer (pH-4.2): acetonitrile (40:60V/V) with the effluent flow rate...

Dillip Kumar Dash*and Miral Vadher

Department of Quality Assurance, N. R. Vekaria Institute of Pharmacy, Junagadh-362001, Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5255-59

5255-5259

70925

1094

25.

SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL AND PESTICIDAL ACTIVITY OF ORGANOARSENIC(III) AND ORGANOANTIMONY(III) COMPLEXES WITH N∩S DONOR LIGANDS

Some new Sb(III) and As(III)  complexes of  N∩S donor ligands  N’-[1-(2-oxo-2H-chrome-3yl-ethylidene]  - hydrazinecarbodithionic acid methyl ester (L1H)  and N’ - [1-(2-oxo-2H-chrome-3yl - ethylidene] -hydrazinecarbodithionic acid benzyl ester (L2H) have been synthesized. All the synthesized compounds were characterized by elemental analyses, melting point determinations and a combinati...

N. Fahmi, A. Kumari and R. V. Singh

Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5260-66

5260-5266

3309

838

26.

IN-VITRO ANTIFUNGAL SUSCEPTIBILITY REVEALS OCCURRENCE OF AZOLE AND ALLYLAMINE RESISTANCE AMONG CLINICAL ISOLATES OF CANDIDA ALBICANS AND CANDIDA NON ALBICANS FROM CENTRAL INDIA

Background: Drug resistance among Candida species constitutes the most significant problem in the treatment of Candidiasis.Systematic studies on antifungal drug susceptibility which may be useful in deciding clinical strategies are not routinely done in India and other developing countries. Objective: Aim of this study was testing sensitivity of clinical isolates of Candida albicans and non albica...

Shruti Singh *, Shesh R. Nawange and Nidhi Warthe

Department of Biotechnology, Mithibai College, Vile parle (W), Mumbai - 400056, Maharashtra, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5267-75

5267-5275

2165

726

27.

SPECTROFLUORIMETRIC STUDIES ON THE INTERACTION OF MOXIFLOXACIN WITH HERRING SPERM DNA

Moxifloxacin (MOX) is a fourth-generation synthetic fluoroquinolone antibacterial agent with many important therapeutic properties.  Fluorescence measurement was used to study the interaction of MOX with herring sperm DNA (Hs-DNA) in Tris-HCl, buffer of pH 7.4.  The intercalative binding mode and a static quenching mechanism were confirmed by the Stern-Volmer quenching rate constant (Kq) of 5.61...

Babu G. Gowda*, M. Mallappa, A. Shivakumar and R. Nageshbabu

Assistant Professor, Department of Chemistry, Maharani’s Science College for Women, Palace Road, Bangalore-560 001 India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5276-82

5276-5282

1788

934

28.

GAS CHROMATOGRAPHY AND MASS SPECTROMETRY ANALYSIS OF SOLANUM VILLOSUM (MILL) (SOLANACEAE)

In the present study the bioactive compounds of Solanum villosum leaves extract were used to evaluate by GC – MS method. 50g of fine powder was packed with No.1 Whatman filter paper and placed in soxhlet apparatus along with ethanol. The crude extract were collected and dried at room temperature, 30˚C after which yield was weighed and then performed to GC-MS analysis.  The Ethanol leaf extrac...

R. Venkatesh *, R. Vidya, and K. Kalaivani

Department of Biochemistry, Kongunadu Arts and Science College (Autonomous), Coimbatore, Tamil Nadu-641029, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5283-87

5283-5287

2670

2262

29.

EFFECT OF Di-n-BUTYL PHTHALATE ON THE EPIDIDYMAL ANTIOXIDANT SYSTEM OF WISTAR RATS

The study evaluates the effect of di-n-butyl phthalate (DBP), a ubiquitous environmental contaminant, on epididymal antioxidant system of Wistar rats. Adult Wistar rats were orally administered DBP (500, 1000 and 1500 mg/ kg b.wt) for 7 days. Body weight increased significantly while caput and cauda epididymal weight decreased. Significant reduction in total protein concentration, lipid soluble an...

Neena Nair *, Deepa Kumari, Sushila Bedwal, Seema Prasad, Ranjana Agarwal, Sangeeta Joshi and Ranveer Singh Bedwal

Cell Biology Laboratory, Center for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur-302055, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5288-92

5288-5292

1731

621

30.

EVALUATION OF ALOE BARBADENSIS MILL. GEL ON LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME (PCOS) RAT MODEL- A DOSE DEPENDENT STUDY

Aim of the present study was to investigate the dose dependent effect of Aloe vera gel [5 mg, 10 mg, 15 mg of dry weight for 60 days each group] on Polycystic Ovarian Syndrome (PCOS) rat model. Charles Foster adult female (200-225 g weight) rats were treated orally with letrozole (non-steroidal aromatase inhibitor) at a dose of 0.5 mg/kg body weight daily for 21 days for PCOS model development, th...

M. Radha, N. Padamnabhi and N. Laxmipriya*

Assistant Professor Department of Biochemistry Faculty of Science, The M S University of Baroda, Sayajigunj, Vadodara- 390 002. Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5293-00

5293-5300

2684

1025

31.

DEVELOPMENT AND EVALUATION OF BILAYER FLOATING DOSAGE FORM OF CARBIDOPA AND LEVODOPA FOR TREATMENT OF PARKINSON’S DISEASE

The combination of Levodopa and Carbidopa is widely prescribed for Parkinson's disease. Levodopa easily crosses the blood-brain barrier and presumably converted to dopamine in the brain. Carbidopa inhibits decarboxylation of peripheral Levodopa but not of Levodopa within the central nervous system as it does not cross the blood-brain barrier. The purpose of present work was to develop bilayer floa...

Dasharath M. Patel* and Pratik R. Gajjar

Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5301-14

5301-5314

2114

683

32.

IMMUNOLOCALIZATION OF METALLOTHIONEIN IN DIFFERENT TISSUES OF FRESH WATER CATFISH, CLARIAS GARIEPINUS ON EXPOSURE TO CADMIUM

Metallothionein (MT) is a cysteine-rich protein that binds to heavy metals, and it is induced by them. The objective of this study to identify the MT protein induction/expression and localization in liver and kidney tissues (treated with 20 mg/L of CdCl2 for 72 hours) by immunohistochemical techniques and Western Blotting methods in the fresh water catfish, Clarias gariepinus. MT expression (MT-I ...

Sumit Rose *, S.Vincent , B.Meena , A.Suresh and R.Mani

Department of Zoology, Loyola College, Chennai-600 034. Tamil Nadu India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5315-20

5315-5320

1573

692

33.

BIOSYNTHESIS OF SILVER NANOPARTICLES FROM MORINDA COREIA BUCH.-HAM. AND IT’S ANTIBACTERIAL ACTIVITY

The synthesis of nanoparticles has become the matter of great interest in recent times due to its various advantageous properties and applications in various fields. Though physical and chemical methods are more popular for nanoparticle synthesis, the biogenic production is a better option due to eco-friendliness. Morinda coreia leaf ethanol extracts was screened for the synthesis of Silver nanopa...

Antonysamy Kala, Soosai Sathya, Sebastin Soosairaj* and Prakasam Raja

Department of Botany, St. Joseph’s College, Tiruchirappalli-620002, Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5321-27

5321-5327

1911

763

34.

HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHY (HPTLC) METHOD FOR THE DETERMINATION OF SOME AMINO ACIDS FROM TWO SPECIES OF MARCHANTIA

The objective of the present study is to develop a rapid HPTLC method for the identification, separation and quantification of some amino acidsfrom two species of Marchantia. Three different mobile phases were used for the separation and estimation of eight amino acids (alanine, glycine, methionine, threonine, valine, leucine, histidine and isoleucine). TheHPTLC analysis of Marchantia palmata and ...

Kanchna Devi, Sunita Kapila* and Anju Rao

Department of Botany, Panjab University, Chandigarh, Pin-160014, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5328-33

5328-5333

2225

882

35.

EVALUATION OF α-AMYLASE, α-GLUCOSIDASE AND ALDOSE REDUCTASE INHIBITORS IN ETHYL ACETATE EXTRACTS OF ENDOPHYTIC FUNGI ISOLATED FROM ANTI-DIABETIC MEDICINAL PLANTS

Twenty two endophytic fungi were isolated from anti-diabetic plants Momordica charantia and Trigonella foenum-graceum. Ethyl acetate extracts of all fungal isolates were tested for inhibition of aldose reductase and carbohydrate metabolizing enzymes. Ethyl acetate extracts of nine endophytic fungi were found to be positive for α- amylase and α- glucosidase inhibitors. Crude extracts of fungal is...

N. Pavithra , L. Sathish , Nagasai, Babu , V. Venkatarathanamma , H. Pushpalatha , G. Bhanuprakash Reddy and K. Ananda *

Assistant Professor Poornaprajna Institute of Scientific Research, Bidalur Post, Devanahalli Bangalore-562110, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5334-41

5334-5341

3137

1725

36.

ANTI MRSA AND ANTITUBERCULAR ACTIVITY OF PHENOXAZINONE CONTAINING MOLECULE FROM BORRA CAVES STREPTOMYCES SP. BCA1

An attempt was made to study the anti MRSA and antitubercularactivity of Streptomyces sp. BCA1 isolated from Borra Caves soil. In agar plug method, strain BCA1 showed 12-17 mm inhibition against Gram positive and Gram negative bacteria, including MRSA. Crude pigment produced from strain BCA1 by agar surface fermentation showed 15 – 17 mm inhibition in disc diffusion method against bacterial path...

M. Radhakrishnan *, V. Anuradha Raman , S. Bharathi , R. Balagurunathan and Vanaja Kumar

M.Sc., M.Phil., Ph.D., Scientist C Centre for Drug Discovery and Development, Sathyabama University, Jeppiaar Nagar, Rajiv Gandhi Road, Chennai – 600 119. Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5342-48

5342-5348

1989

946

37.

ACUTE AND 28 DAYS REPEATED ORAL TOXICITY STUDIES OF A SIDDHA DRUG PIRANDAI UPPU ON WISTAR ALBINO RAT

Pirandai uppu (PU) a herbo mineral formulation has been employed as a traditional siddha remedy for diarrhea since long time. Diarrheal diseases remain one of a leading cause of morbidity and mortality in the world, particularly in developing countries. As a mandate, steps were taken to evaluate safety profile of PU in animal model under OECD guidelines. Acute toxicity studies done on female wista...

K. R. Kanian , K. Kanakavalli , V. Thanigavelan and V. Kaliyamurthi

PG Scholar, Pothu Maruthuvam Branch, Government siddha medical college, Chennai, Tamilnadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5349-55

5349-5355

8620

882

38.

PREDICTION OF LD50 OF SOME COMMON PESTICIDES THROUGH QSAR (AN ALTERNATIVE METHOD TO SAVE EXPERIMENTAL ANIMALS)

The most common test of acute toxicity is the LD50 test. LD50 means, the lethal dose of a substance that will kills 50% of animals. But this requires large number of animals. To reduce the sacrifice of animals. In present study we are using QSAR based software T.E.S.T. (toxicity estimation search tool 4.1 version) for predicting oral LD50. For prediction of oral LD50 we have taken 100 insecticides...

S.P. Agrawal * and V.L. Saxena

Lecturer Dept. of Zoology D-A.V. (PG) College Kanpur, UP 208001, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5356-73

5356-5373

2174

773

39.

EVALUATION OF RATIONAL USAGE OF ANTIMICROBIAL AGENTS IN THE PAEDIATRIC DEPARTMENT AT TERTIARY TEACHING CARE HOSPITAL, GUJRAT

Background: Prescription of drugs which needs to be continuously assessed and refined according to disease progression. It not only reflects the physician’s knowledge about drugs but also know the pathophysiology of diseases and attitude towards rational prescribing.  Methods: Retrospective study was carried out by collecting 350 prescriptions containing antimicrobial agents of the indoor patie...

Vipul Prajapati * and J. D. Bhatt

M.B.B.S, M.D (Pharmacology) Assistant professor, Department of pharmacology, AMC MET Medical College, Ahmedabad-380008, Gujrat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5374-81

5374-5381

1756

629

40.

DESIGN AND DEVELOPMENT OF IONTOPHORETIC DRUG DELIVERY SYSTEM OF L-TYROSINE

This study was aimed to design and develop iontophoretic drug delivery of L-Tyrosine in the treatment of phenylketonuria. The In-house iontophoretic drug delivery device was designed and validation was performed respect to Current intensity, Voltage, and Power Resistance. The study was also focused various parameters such as effect of different drug concentrations (2.5mg/5ml, 5mg/5ml, 10mg/5ml, 15...

N. Kirubakaran*, K. Reeta vijaya Rani, A. Anithaa and R. Senthamarai

Department of Pharmaceutics, Periyar college of Pharmaceutical Sciences, Trichy, Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5382-88

5382-5388

1628

627

41.

COMPARATIVE ANTIBIOTIC POTENTIAL OF DIFFERENT VARIETIES OF POTATO TUBERS

Objective: Potato (Solanum tuberosum L.) is a major world food crop next in production to maize, rice and wheat. Potatoes are a source of dietary energy due to their carbohydrate level and also contain a high value of vitamins. The objective of this study was determine the phytochemical constituents and antimicrobial activities of four common potato varieties developed by CPRI (Central Potato Rese...

Jagdeep Singh Pannu*, Rajeev Kumar Kapoor and Ruby Yadav

Department of Microbiology, M. D. University, Rohtak, Haryana, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5389-93

5389-5393

2375

872

42.

DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR THE ESTIMATION OF DAPAGLIFLOZIN IN API

An accurate, precise, specific and rapid RP-HPLC method was developed and subsequently validated for the determination of Dapagliflogin in API. Better separation of the drug was achieved on BDS column (250×4.5mm, 5µ) with a mobile phase consisting of a mixture of ortho phosphoric acid and acetonitrile (45:55 v/v) at a flow rate of 1ml/min, with detection at 245nm using Photo Diode Array (PDA) de...

Manasa. Sanagapati *, K. Dhanalakshmi , G. Nagarjunareddy and S. Sreenivasa

M. Pharmacy, Department of pharmaceutical analysis, KLR Pharmacy College, Palvoncha, Telangana, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5394-97

5394-5397

4737

1813

43.

THE EFFECT OF CINNAMALDEHYDE ON HIGH FAT DIET INDUCED WISTAR RATS – A PRELIMINARY STUDY

Anti-obesity effect of Cinnamaldehyde and Orlistat on High fat diet induced obese rats was investigated. 30 male wistar albino rats were divided into 5 groups: control group fed on normal standard diet; HFD group; Orlistat (HFD+ 50mg/kg body weight; CA (HFD+ 40mg/Kg body weight) and CA (HFD+ 80mg/Kg body weight) for 8 weeks. The anti obesity activity of CA and OR was estimated in terms of Food int...

D Haripriya and K Vijayalakshmi *

Department of Biochemistry , Bharathi Women’s (Autonomous) College, Chennai - 600108, Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5398-04

5398-5404

2364

858

44.

IMPROVEMENT SOLUBILITY OF ATORVASTATIN CALCIUM USING SOLID DISPERSION TECHNIQUE

This study focused on an investigation of dissolution property of solid dispersion system consisting of drug, exipients, and carrier. The purpose of this study was to enhance the dissolution of Atorvastatin Calcium, a practically water-insoluble drug by preparation of solid dispersion using hydrophilic polymers and a carrier PEG 6000. Solid dispersion formulations were prepared by using The Melt S...

Md. Raihan Sarkar *, A.S.M. Monjur-Al-Hossain , Razia Sultana and A B M Faroque

Department of Pharmacy, Jagannath University, Dhaka 1000, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5405-10

5405-5410

3067

1045

45.

SIMULTANEOUS QUANTITATION AND VALIDATION OF CHLORPHENIRAMINE MALEATE, PHENYLPROPANOLAMINE HYDROCHLORIDE AND PARACETAMOL BY RP-HPLC IN BULK DRUG AND FORMULATION

A HPLC method has been described for simultaneous determination of Chlorpheniramine Maleate, Phenylpropanolamine Hydrochloride and Paracetamol in formulation. This method is based on HPLC separation of the three drugs on the Thermo Hypersil Gold C18 column(250mm ×4.6mm, 5.0µ), with isocratic conditions and mobile phase containing methanol: 0.01M disodium hydrogen phosphate dihydrate buffer pH 7 ...

K. S. Rasal *, A. L. Suryan and S. R. Dhaneshwar

Assistant Professor, AES, College of Pharmacy (B.Pharm), University of Pune, Pune, Maharashtra, India. 411041.

DOI: : http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5411-19

5411-5419

2679

1519

46.

ANTI DEPRESSANT ACTIVITY OF FRESH LEAVES OF TINOSPORA CORDIFOLIA MIERS (AMRUTHABALLI) IN ALBINO MICE

Objectives: To evaluate the antidepressant activity of fresh leaves of Tinospora cordifolia in albino mice. Materials and Methods: Swiss albino mice weighing 25-30grams of either sex were selected for the study. Six animals were allocated to each experimental group. Animals were divided into 4 groups of 6 mice each. Group 1 - Control group treated with normal saline (0.1ml/10gm), Group 2 received ...

H. L. Kalabharathi *, P. S. Vaibhavi, Sushma Naidu, V. H. Pushpa and S. L. Shruthi

Department of Pharmacology, JSS Medical College, JSS University Mysore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5420-24

5420-5424

2133

658

47.

ANTIBACTERIAL ACTIVITY OF LIBYAN SEAWEED EXTRACTS

Marine organisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. The Libyan marine biodiversity including macroalgae remains partially unexplored in term of their potential bioactivities. Method: The phytochemical analysis of the alcoholic extracts of some commonly occurring seaweed Cystos...

Salmin K. Alshalmani* , Nada H. Zobi and Ismaeel H Bozakouk

Department of Pharmacognosy, Faculty of Pharmacy, University of Benghazi, Benghazi, Libya.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5425-29

5425-5429

2042

773

48.

NUTRITIONAL AND MEDICINAL VALUES OF SELECTED WILD CUCURBITS AVAILABLE IN SIMILIPAL BIOSPHERE RESERVE FOREST, ODISHA

Cucurbitaceae commonly known as “Guard family” is distributed throughout India. Most of them, are perennial climbers with attractive flowers. The family includes plants having food as well as medicinal values. The species of the family are collectively known as cucurbits. They grow wild as well as cultivated throughout the state in Odisha in general and Similipal Biosphere Reserve (SBR) forest...

Prakash Kumar Tripathy, Sanjeet Kumar* and Padan Kumar Jena

Department of Botany, Ravenshaw University, Cuttack- 753 003, Odisha, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(10).5430-37

5430-5437

2377

927

49.

STANDADADIZATION AND STABILITY INDICATING STUDIES BY RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF CANDESARTAN CILEXETIL & HYDROCHLORTHIAZIDE IN TABLET DOSAGE FORM

A rapid, selective, precise, accurate, rugged and robust high performance liquid chrmatgraphic (HPLC) method for the simultaneous determination of Candesartan Cilexetil & Hydrochlorthiazide in tablet dosage form .The method was validated according to ICH and FDA guidelines. The chromatography is performed on a Kromasil C8, 150 x 4.6 mm, 5µm, in a gradient mode with a mobile phase of Water, ac...

G. Mani Kumar* and J.V.L.N. Seshagiri Rao

Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences & Technologies, JNTU Kakinada, Kakinada, Andhra Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5438-46

5438-5446

1792

698

50.

COMPARATIVE EFFECT OF DIFFERENT HIGH FUNCTIONALITY EXCIPIENTS ON VARIOUS CHARACTERISTICS OF VARDENAFIL HCL TABLETS (BCS II DRUG)

Direct Compression is becoming a preferred manufacturing process in order to speed up the manufacturing and reduce costs. Although a major requirement for direct compression process is selection of excipients with the optimum physical characteristics that increase final flowability and compressibility of the ready for compression (RFC) tableting blend. By using combinations of excipients and novel...

Maulin A. Patel* and Prashant L. Pingale

Department of Pharmaceutics and Quality Assurance, School of Pharmacy and Technology Management, NMIMS, Shirpur-425405 India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5447-51

5447-5451

2108

1406

51.

EXPLORING ANTIOXIDANT ACTIVITY AND DNA PROTECTION POTENTIAL OF CHONEMORPHA FRAGRANS

Chonemorpha fragrans (Moon) Alston is a liana belongs to family Apocynaceae. Due to its ethanobotanical importance, it is used intraditional medicinal systems as a part of various medicinal preparations. In the work presented here the plant has been explored for its antioxidant potential and DNA protection ability. The antioxidant potential of C. fragrans was determined using DPPH, FRAP, Phosphomo...

Pradnya Kedari and Nutan Malpathak *

Department of Botany, University of Pune, Ganeshkhind Road, Pune 411007, Maharashtra, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5452-62

5452-5462

1854

1222

52.

ACUTE AND SUB ACUTE TOXICITY STUDY ON SIDDHA DRUG RASA CHENDOORAM

Herbal and herbo mineral preparations are being traditionally used in Indian system of Medicine especially in Siddha Medicine. Herbo mineral preparations have longer Shelf life. Rasa Chendooram (RC) is prepared as per classical text book of Prana Rakshamirtha Sindhu, for Vadha diseases. Before conducting clinical trial, Pre clinical study should be undergone as per WHO guidelines .The clinical tri...

M. Jayabharathi *, M. Mohamed Mustafa and P. Sathiyarajeswaran

Post.Graduate Scholar Sirappu Maruthuvam Dept. GSMC, Chennai. Tamil Nadu.India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5463-68

5463-5468

2131

729

53.

CONTROL OF RICE BLIGHT PATHOGEN XANTHOMONAS ORYZAE THROUGH HERBAL PLANT EXTRACT

Rice is the most widely cultivated food crop over world, whose production is effected by many diseases like as fungal, bacterial and viral. Bacterial blight disease of rice caused by Xanthomonas oryzae. Chemical substance like Bordeaux mixture, copper and mercurial compounds have been used. Extensive use of these chemical causes harmful impacts on human and environment. For reducing problems assoc...

Manjoo Rani and Nand K. Singh*

Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad-211004 (UP) India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5469-73

5469-5473

2076

797

54.

INSILCO IDENTIFICATION OF SUITABLE ACETUYLCHOLINESTERASE INHIBITORS FROM MORINDA CITRIFOLIA LINN. WITH REFERENCE TO ALZHEIMER’S DISEASE

Alzheimer’s disease, the most common form of dementia accounting for about 50-60% of the overall cases among persons over 65 years of age is characterized by the progressive decline in cognitive function, mediated through learning and memory. According to Cholinergic hypothesis, AD is caused by reduced synthesis of the neurotransmitter ACh, wherein the AChE levels were increased which causes dam...

Kukkarasapalli Praveen and Kuna Yellamma*

Department of Zoology, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5474-81

5474-5481

1956

776

55.

PHARMACOGNOSTICAL AND PHYSICOCHEMICAL STUDIES ON ADHATODA VASICA NEES. SEED

Adhatoda vasica Nees. has been used in India for more than 2000 years. The drug contains leaf, stem, flower, fruit and seeds. The fruit which holds the most potentialof the herb is a small capsule with four seeds. No reports are available for the pharmacognostical study of the seed, hence the present study was undertaken to investigate the macroscopic, microscopic, powder microscopic, physicochemi...

B. Akila *, K. Manickavasakam and R. Shakila

M.D (s) -PhD Scholar Department of Maruthuvam, National Institute of Siddha, Tambaram sanatorium, Chennai-600047, Tamilnadu , India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5482-90

5482-5490

2190

824

56.

METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LAMIVUDINE, TENOFOVIR AND EFAVIRENZ IN COMBINED TABLET DOSAGE FORM BY RP-HPLC AND UV-SPECTROSCOPIC METHOD

A rapid and sensitive RP-HPLC method with UV detection and UV spectrophotometric method for the determination of Lamivudine, Tenofovir and Efavirenz simultaneously in combined tablet dosage form was developed. Chromatography was performed with mobile phase containing a mixture of methanol: Water (pH adjusted to 2.5) and 0.1 % TEA in the proportion of (68: 32 % v/v) the samples were injected onto S...

Akula Srinath*, B. Sneha, Akhila Alladi, Rayees Ahmed and R.G. Kulkarni

Department of Pharmaceutical Analysis, Trinity College of Pharmacy, Peddapally, Karimnagar, A.P., India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5491-97

5491-5497

4034

1456

57.

SIMULTANEOUS DETERMINATION OF RESIDUAL NSAIDs AND ANTI-BIOTICS IN RAW MILK BY RP-HPLC

The presence of Non-steroidal Anti-Inflammatory drugs (NSAIDs) and β-lactam residues in foodstuff constitutes a potential risk to the human health and undesirable effects on consumers. Now-a-days these drug residues are also recognized as an emerging environmental problem. The present work describes the development of a sensitive, reproducible, and accurate method using liquid chromatography with...

M. Pushpa Harshita*, J. Teja Aparna, L. Kumar Reddy, P. Venkata Suresh, A. Elphine Prabahar and N. Rama Rao

Department of Pharmaceutical Analysis, Chalapathi institute of pharmaceutical sciences, Lam, Guntur, Andhra Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5498-02

5498-5502

2086

791

58.

CHEMICAL CONSTITUENTS OF THE ANTIDIABETIC PLANT RAVENALA MADAGASCARIENSIS

Ravenala madagascariensis Sonn. is one of the most popular medicinal plants in Madagascar, India and several African countries. It is used in the treatment of many diseases, and particularly in those of diabetes. The duration of treatment, often for life, and its relatively high cost for certain social categories, constrain more and more patients to use this plant. Its chemical constituents were s...

H. Ramiarantsoa *, P. A. Yao-Kouassi, C. Kanko , K.M. Assi , A. L. Djakoure and F. Z. Tonzibo

Laboratoire de Chimie Organique Biologique UFR-SSMT Universite Université Félix Houphouët-Boigny, 22 BP 582, Abidjan, Côte d’Ivoire

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5503-10

5503-5510

1929

676

59.

BIOLOGICAL SYNTHESIS OF SILVER NANOPARTICLES OF ADIANTUM CAPILLUS-VENERIS L. AND THEIR EVALUATION OF ANTIBACTERIAL ACTIVITY AGAINST HUMAN PATHOGENIC BACTERIA

To develop a novel approach for the biological synthesis of silver nanoparticles using water extract of whole plant parts ofAdiantum capillus-veneris L. which has been proven to be  active against human pathogenic bacteria such as Streptococcus pyogenes, Staphylococcus aereus, Escherichia coli and Klebsiella pneumonia. Characterization of nanoparticles was determined by using Ultra Violet-Visible...

S. Santhoshkumar * and N. Nagarajan

PG and Research Department of Botany, Kongunadu Arts and Science College (Autonomous), Coimbatore- 641 029, Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5511-18

5511-5518

2333

942

60.

TRACE METAL ACCUMULATION IN VEGETABLES GROWN IN INDUSTRIAL AND SEMI-URBAN AREAS OF SINGRAULI DISTRICT OF MADHYA PRADESH INDIA

The study undertaken for trace metal accumulation by fly ash, coal and mines waste in Singrauli industrialized district of Madhya Pradesh, India, using atomic absorption spectrometry. Present studies were focused into three Industrial, semi-urban and rural areas. Mostly sources of trace metals to plants are the air or soil from which these elements are taken up by foliage or root. Soil grown veget...

Rajesh Pandey * and Sunil K. Pandey

Department of Biochemistry Awadesh Pratap Singh University Rewa (M.P.) - 486003, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5519-29

5519-5529

2174

901

61.

STABILITY INDICATING METHOD OF CARBIDOPA AND LEVODOPA ASSAY IN CARBIDOPA, LEVODOPA AND ENTACAPONE FILM COATED TABLETS BY RP- HPLC

ABSTRACT: The present work describes high sensitive and reproducible method of Carbidopa and Levodopa assay in Carbidopa, Entacapone and Levodopa film coated tablet.  It was developed by usingkromosil C18, 125mm × 4.0mm × 5µm column, mobile phase (A) phosphate buffer pH 3.8 and, mobile phase (B) methanol and water with gradient method.  Retention time of carbidopa and levodopa is 3.83 and 1.8...

Naresh Konduru and G.V. Madhuri *

Assistant Professor, Department of chemistry, Gitam university, Hyderabad campus, Rudraram Medak, A.P- 502329, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5530-38

5530-5553

4813

2584

62.

DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING ORODISPERSIBLE FILM OF BACLOFEN USING 32 CENTRAL COMPOSITE DESIGN

The aim of present research work to develop and optimize orodispersible film of baclofen to improve bioavailability and patient compliance. Orodispersible films of baclofen were prepared by solvent casting method using HPMC E5 LV as a film forming polymer and propylene glycol as a plasticizer, crospovidone as a superdisintegrant and sucralose was added as a sweetener. The physical mixture of drug ...

Patel Priyanka*, Limbashiya Rikisha, Chavda Mayur and Shah Ujjaval

Bhagwan Mahavir College of Pharmacy, Surat, Gujrat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5539-47

5539-5547

2764

757

63.

A GREENER CHEMISTRY APPROACH FOR SYNTHESIS OF 4-(4-HYDROXYPHENYL)-6-METHYL-2-OXO-1,2,3,4 TETRAHYDROPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

The objective of present research work is to provide green technique for synthesis of 4-(4-Hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester. Pyrimidine derivatives are well known in the pharmaceutical industry and exhibit to possess a broad spectrum of biological activities which makes their wider application as a key building block for pharmaceutical agents...

D. Jagwani* and P. Joshi

Medi-Caps Group of Institutions, Pigdamber, Rau, Indore- 453331, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5548-55

5548-5555

2832

1249

64.

MICROWAVE ASSISTED SYNTHESIS & QSAR STUDY OF SOME NOVEL PYRAZOLYL THIAZINE DERIVATIVES

This work involves synthesis of pyrazolyl thiazine derivatives from different chalcones [1(a-b)] synthesized from substituted   acetophenones and different aromatic aldehydes in basic medium by Claisen-Schmidt reaction. These chalcones [1(a-b)] on condensation with different hydrazides [2(a-b)] and isothiocyanates [3(a-b)] when irradiated with microwaves (20%, 140watts) in scientific microwave o...

V. S. Kapase, S. S. Khot, S. A. Kenawade and S. R. Dhongade*

Research Laboratory in Heterocyclic Chemistry, Devchand College, Arjunnagar, Maharastra India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5556-63

5556-5563

1702

1019

65.

TRYPSIN AND PROTEIN DENATURATION INHIBITORY ACTIVITY OF DIFFERENT FRACTIONATION AND ISOLATED COMPOUND OF LEAF AND ROOT OF JUSTICIA GENDARUSSA

Rheumatoid arthritis is a major ailment among autoimmune disorders. A large number of herbal extracts were used for the treatment of various types of rheumatoid disorder. The leaf and root of Justicia gendarussa belonging to Acanthaceae family, commonly known as Nilinirgundi is traditionally used for chronic rheumatism. The present study deals with in-vitro anti-arthritic activity in pharmacologic...

S. S. Patel * and M. N. Zaveri

Department of Pharmacognosy, K.B. Institute of Pharmaceutical Education and Research, Sector-23, GH-6, Gandhinagar-382023, Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5564-71

5564-5571

2259

786

66.

ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF HEARTWOOD OF BIJASAR (PTEROCARPUS MARSUPIUM ROXB.) IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED TYPE 2 DIABETIC RATS

The antidiabetic potential of ethanolic extract of bijasar (Pterocarpus marsupium Roxb.) heartwood was evaluated in the streptozotocin-nicotinamide induced type 2 diabetic model. Graded doses of the ethanolic heartwood extract were administered to normal and experimental diabetic rats for 12 days. Significant (p < 0.05) reduction in fasting blood glucose levels were observed in the normal as we...

U.K. Patil * and M.K. Tripathy

Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, 470003, India

DOI: 10.13040/IJPSR.0975-8232.5(12). 5572- 77

5572- 5577

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