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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 7 (2016) - Issue 9, September

Review Articles

 
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1.

CURRENT AND NOVEL TECHNIQUES IN THE OPHTHALMIC DRUG DELIVERY SYSTEMS

For human survival, vision or sight is extremely important. Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. There are both conventional and novel drug deliveries available as topical administration for the treatment of diseases related to the eye. Conventional dosage form includes ophthalmic solutions, suspen...

Pravin K Shende * and Rashmi Godbole

Shobhaben Pratapbhai Patel-School of Pharmacy and Technology Management, SVKM’s NMIMS University, Mumbai, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3557-66

3557-66

3951

1179

2.

AUTISM: AN EARLY-ONSET NEURODEVELOPMENTAL DISORDER

Autism is an early-onset neurodevelopmental disorder characterized by difficulties in social interaction and communication, and the repetitive interests or restricted interests and behaviors. Approximately 67 million people are affected by autism around the world. Autism has increased to epidemic proportions, affecting four times as many males and females. The exact etiology of autism remains larg...

Ashwani Arya * and Gulshan Sindhwani

Department of Pharmaceutical Education and Research, BPS Women University, South Campus, Bhainswal Kalan, Sonipat, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3567-75

3567-75

2693

760

3.

HERB-DRUG INTERACTIONS: AN OVERVIEW OF MECHANISMS AND CLINICAL ASPECTS

Millions of people today use herbs either as food or in the form of medicine along with prescription and non prescription medications. Although considered natural and safe, many of these herbs can interact with other medications, causing either potentially dangerous side effects and/or reduced benefits from the medication. Both pharmacokinetic and pharmacodynamic mechanisms are involved in these i...

Sandhya Mamindla*, Prasad K.V.S.R.G and Bharathi Koganti

Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam, Tirupati, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3576-86

3576-86

4443

1070

4.

A REVIEW ON THE ROLE OF PHARMACOGENOMICS IN DRUG DISCOVERY AND DEVELOPMENT

Pharmacogenomics (constitute both branch i.e pharmacology and genetic) is the study of the role of genetics in drug response. It deals with the effect of genetic variation on drug response in patient by correlating the gene expression with the pharmacokinetic parameter i.e absorption, distribution metabolism and excreation. The Pharmacogenomics is used in the research to increase the safety and ef...

Anup Ojha* and Tanuj Joshi

Department of Pharmaceutical Sciences, Kumaun University Bhimtal Campus, Bhimtal (Nainital), Uttarakhand, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3587-95

3587-95

4220

939

5.

ANTIBIOTIC DE-ESCALATION IN THE INTENSIVE THERAPY UNIT- A REVIEW

An antibiotic may be defined as a substance or compound that kills or inhibits the growth of, bacteria. Antibiotics belong to the broader group of antimicrobial compounds, used to treat infections caused by microorganisms, including fungi and protozoa, viruses. Antibiotic de-escalation is a mechanism whereby the provision of effective initial antibiotic treatment is achieved while avoiding unneces...

Jyoti Sharma *, Sourabh Kosey and Raj Kumar

Department of Pharmacy Practice, I.S.F. College of Pharmacy, Moga, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3596-01

3596-01

2887

835

6.

A REVIEW ON HERBAL PLANTS AS IMMUNOMODULATORS

Herbal immunomodulator is substance which stimulates or suppresses the components of immune system including both innate and adaptive immune responses. The modulation of immune system by various medicinal plant products has become subject for scientific investigations currently worldwide. A number of Indian medicinal plants and various ‘Rasayana’ have been claimed to possess immunomodulatory a...

Namrata Singh *, Mukul Tailang and S.C. Mehta

Department of Pharmacology, G R Medical College, Gwalior, M. P. India

DOI: 10.13040/IJPSR.0975-8232.7(9).3602-10

3602-10

10719

1371

Research Articles

 
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7.

BIOCIDAL EFFICACY OF SYNTHETIC COPOLYESTERS HAVING CHALCONE MOIETY

Two chalcone diols (2E)-1-(4-hydroxyphenyl)-3(4-hydroxy, 3-ethoxy phenyl) prop-en-1-one and (2E)-1-(4-hydroxy-3-methoxy phenyl)-3(4-hydroxy, 3-ethoxy phenyl) prop-en-1-one were synthesized by acid catalyzed ClaisenSchmidt reaction. The synthesized chalcones were made to undergo polymerization using three aliphatic dichlorides namely glutaryl, succinyl and oxalyl chlorides. The polymers were random...

Rajesh Kumari and Tom John *

Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA

DOI: 10.13040/IJPSR.0975-8232.7(9).3611-16

3611-16

2787

618

8.

NEW SAPONINS FROM ALBIZIA LEBBECK (L) BENTH FLOWERS

Two new oleanane triterpene type saponins named lebbeckanin I (1) and lebbeckanin II (2), in addition to a new isomer of methyl inositol, D-1-O-methyl-cis-inositol (3), were isolated from butanol fraction of Albizia lebbeck (L.) Benth flowers. Their structures were established on the basis of spectroscopic analysis including  MS, 1H & 13C NMR, 1H-1H COSY, HSQC & HMBC. The fraction contain...

Afaf E. Abdel Ghani, Gamal A. Dora, Wafaa H. B. Hassan*, Rehab H. Abdallah and E. Abd El-Salam

Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(9).3617-32

3617-32

3013

687

9.

POSSIBLE TRANSMISSION OF DRUG-RESISTANT SALMONELLA TYPHIMURIUM AND LISTERIA MONOCYTOGENES WITHIN THE BEEF INDUSTRY IN ABUJA, NIGERIA

Background: Widespread use of antibiotics in livestock production in large-scale across the globe has become of public and veterinary health importance because of its implication in antibiotic resistance. Adequate data in this area of research is not readily available in Nigeria; this study was undertaken in view of the possible link between antimicrobial resistance in farm animals and humans. Met...

P. Oladosu, M. I. Aboh *, N. Amaeze, E.C. Mmaju, O. Anuforom and M. Emeje

National Institute for Pharmaceutical Research and Development, Centre for Nanomedicine and Biophysical Drug delivery, Abuja, Nigeria

DOI: 10.13040/IJPSR.0975-8232.7(9).3633-42

3633-42

2192

811

10.

DEVELOPMENT OF HERBAL MOSQUITO REPELLENT FORMULATIONS

The present study reports the studies directed towards the development of safe and efficient herbal mosquito repellent formulations obtained by mixing hexane extract of Azadirachta indica seeds, hexane/ethanol extract of Vitex negundo leaves, essential oils from Ocimum sanctum leaves, Curcuma longa rhizomes and Citrus sinensis peels and essential oils of Cymbopogon nardus leaves, Eucalyptus globul...

M. S. N. Ranasinghe *, L. Arambewela and S. Samarasinghe

College of Chemical Sciences, Institute of Chemistry Ceylon, Adamantane House, Welikada Rajagiriya, Sri Lanka

DOI: 10.13040/IJPSR.0975-8232.7(9).3643-48

3643-48

5578

1133

11.

ELICITOR AND PRECURSOR MEDIATED ANTHRAQUINONE PRODUCTION FROM CELL SUSPENSION CULTURES OF OLDENLANDIA UMBELLATA L.

Enhanced production of anthraquinones from cell suspension cultures of Oldenlandia umbellata were established through elicitor or precursor treatment. Stock cell suspension cultures were developed in liquid MS medium supplemented with 2.5 µM NAA using friable calli. Standardization experiments of suspension cultures revealed that 10 µM NAA added liquid MS medium was optimum for the growth and AQ...

S. R. S. Krishnan* and E. A. Siril

Department of Botany, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3649-57

3649-57

2360

777

12.

ASSESSMENTS OF PHYTOCHEMICALS AND HYPOGLYCEMIC ACTIVITY OF LEAVES EXTRACTS OF CARICA PAPAYA IN DIABETIC MICE

Very little knowledge about use of papaya leaves is available in the literature, the leaves of papaya are bitter to taste which explains its therapeutic benefits. The present study was undertaken to assess anti diabetic effects of leaves extracts of Carica Papaya and Glucophage on streptozotocin –induced diabetic mice.  Results indicates that hyperglycemic level in diabetic mice was   normali...

K. Sobia, M. A. Javaid, M. Sheeraz Ahmad, Q. Rehmatullah, G. Hina , B. Iram, A. Pervaiz, B. Farhana, J. Nyla and M. Gulfraz *

Institute of Biochemistry and Biotechnology, PMAS Arid Agriculture University Rawalpindi, Pakistan

DOI: 10.13040/IJPSR.0975-8232.7(9).3658-65

3658-65

2424

755

13.

ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF FOMITOPSIS DOCHMIUS (BERK. & BROOME) RYVARDEN

The antioxidant and anti-inflammatory activities of various solvent extracts of Fomitopsis dochmius, a polypore found in Western Ghats of Kerala, India were investigated.  Petroleum ether (PE), ethyl acetate (EA), 70 % aqueous ethanol (ETH) and hot water (AQ) extracts of the fruiting bodies of the mushroom were examined for their antioxidant activities.  PE was found to show activity against hyd...

K. S. Ravikumar, P. V. Greeshma, Varughese George and K. K. Janardhanan *

Department of Microbiology, Amala Cancer Research Centre, Thrissur, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3666-74

3666-74

1718

572

14.

EVALUATION OF ANTI-ARTHRITIC POTENTIAL OF THE HYDRO-ALCOHOLIC EXTRACT OF THE STEM BARK OF PLUMERIA RUBRA IN FREUND’S COMPLETE ADJUVANT-INDUCED ARTHRITIS IN RATS.

To investigate the anti-arthritis effects of hydro-alcoholic stem bark extract (HSBE) of Plumeria rubra in Complete Freund’s adjuvant (CFA) induced arthritis model in wistar albino rats. Paw edema was produced by sub-plantar injection of 0.1 ml of complete Freund’s adjuvant (CFA) and paw volume was measured with plethysmometer. HSBE of the plant P. rubra (250 mg/kg & 500 mg/kg body weight)...

P. Mondal, S. Das, K. Mahato, S. Borah, J. Ali Junejo and K. Zaman*

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3675-88

3675-88

2048

565

15.

MODIFIED TSBB CULTURE MEDIA ENHANCE FASTER GROWTH OF STREPTOCOCCI MUTANS AS COMPARED TO EXISTING CULTURE MEDIA

There are various studies on growth of Streptococcus mutans which was done by different scientists on different media but it has been found that there is still some deficiency in existing medium. In our study we have tried to prepare a modified, less laborious and more selective medium for Streptococcus mutans which is specific for their growth. We studied 10 plaque samples from caries active scho...

Sapna Singh, Neha Vishnoi , Deepak Dwivedi , Mayuri Khare and Vinod Singh *

Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3689-94

3689-94

2575

533

16.

ASSOCIATION OF TLR2 AND IL-8 POLYMORPHISMS AND THEIR EXPRESSION IN GUILLAIN-BARRÉ SYNDROME

Guillain-Barré syndrome (GBS) is an acute inflammatory, autoimmune disorder of peripheral nervous system. Association of TLR2 and IL-8 polymorphism with higher expression level has already been studied in many inflammatory and autoimmune diseases. However, the possible role of TLR2 and IL-8 polymorphism in GBS remains unknown. Therefore, the current study investigated the TLR-2 (Arg677Trp & A...

N. K. Kharwar, K. N. Prasad *, M. Rai, V. K. Paliwal and D. R. Modi

Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow (U.P.), India

DOI: 10.13040/IJPSR.0975-8232.7(9).3695-02

3695-02

1446

397

17.

IN-SILICO DOCKING STUDIES OF PHYTO-LIGANDS AGAINST E. COLI PBP3: APPROACH TOWARDS NOVEL ANTIBACTERIAL THERAPEUTIC AGENT

Emergence of antibiotic resistance has become a serious problem worldwide. The extensive and uncontrolled use of antibiotics increases the number of multi drug resistant (MDR) bacterial strains. The major mechanisms that bacteria evolve to develop resistance against β-lactam class of antibiotics are the production of β-lactamases and expression of low affinity penicillin binding proteins (PBPs)....

P. Sahare and A. Moon *

Department of Biochemistry, RTM Nagpur University, Nagpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3703-11

3703-11

1844

470

18.

EFFECT OF INGREDIENTS OF A LOCAL ANTIDIABETIC FORMULATION IN ENHANCING THE ANTIDIABETIC ACTIVITY OF SALACIA RETICULATA IN ALLOXAN INDUCED DIABETIC RATS

Salacia reticulata, used in traditional and local medicines in Western Ghats of Southern India for the treatment of hyperglycaemia, is widely used for its sugar lowering activity. Accordingly, the present study was designed to investigate the possible actions of ethanolic extract of roots of Salacia reticulate (EESR) and an ethanolic extract of local formulation (EELF) made by mixing roots of Sala...

P. P. John *, Shivesh Jha and Tanveer Naved

Department of Pharmacognosy, Ram-Eesh institute of Vocational & Technical Education, Greater Noida, Gautambudh Nagar, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3712-20

3712-20

1652

622

19.

SIMULTANEOUS ESTIMATION OF DOXOFYLLINE AND AMBROXOL IN TABLET DOSAGE FORM BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

A new, simple, accurate, linear, precise, efficient and reproducible Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method for the simultaneous determination of Ambroxol and Doxofylline in combined tablet dosage form. The chromatographic method was standardized using a Kromosil C18, 150mm × 4.6 mm, 3.5 𝜇 (particle size), Thermo scientific from Germany with isocratic conditions,...

K. Sonia *, M. Nappinnai and K. Manikandan

Department of Pharmaceutical Analysis , SRM College of Pharmacy, Kattankulathur, TN, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3721-27

3721-27

1852

447

20.

EFFECT OF ALOE VERA JUICE ON THE TOXICITY INDUCED BY ISONIAZID AND RIFAMPICIN DRUGS ON COMPLETE BLOOD COUNT IN MALE WISTAR RATS

Male Wistar rats were procured from ‘The Bombay Veterinary College’, Parel, Mumbai. The animals were maintained and housed in cages and were acclimatized in laboratory conditions for ten days prior to the experiment. The experimental rats were fed orally with isoniazid 300 mg/ 70 kg body weight / day; rifampicin 450 mg / 70 kg body weight / day and Aloe vera extract 50 mg/ kg body weight / day...

P. P. Bhise and G. V. Zodape *

Departments of Zoology, S.S. & L.S. Patkar College of Arts and Science & V.P. Varde College of Commerce and Economics, S.V. Road, Goregaon (West), Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3728-33

3728-33

1770

439

21.

THE VERTEX SZEGED INDEX OF TITANIA CARBON NANOTUBES TiO2 (m,n)

Let G=(V,E) be a simple connected molecular graph in chemical graph theory, where the vertex set and edge set of G denoted by V(G) and E(G) respectively and its vertices correspond to the atoms and the edges correspond to the bonds. A topological index of a graph G is a numeric quantity related to G which is invariant under automorphisms of G. In this paper, the vertex Szeged index of Titania carb...

Mohammad Reza Farahani, R. Pradeep Kumar , M. R. Rajesh Kanna and Shaohui Wang

Department of Applied Mathematics, Iran University of Science and Technology (IUST) Narmak, Tehran, Iran

DOI: 10.13040/IJPSR.0975-8232.7(9).3734-41

3734-41

1650

389

22.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFPODOXIME PROXETIL AND LEVOFLOXACIN HEMIHYDRATE IN COMBINED DOSAGE FORM

A simple, accurate, precise, rapid and economical RP-HPLC method was developed for the estimation of Cefpodoxime Proxetil (CPD) and Levofloxacin hemihydrate (LVX) in tablet dosage form. In Agilent – 1100/1200 Series, using C18 (250 x 4.6 mm x 5μ) column and with mobile phase composition of Phosphate buffer: Acetonitrile (pH 6.0) (50:50 v/v) at a flow rate of 1 ml/min was used. Detection was car...

Shuchi M. Desai *, Hitesh Dalwadi, Dhansukh Viradiya

ROFEL Shri G.M Bilakhia college of Pharmacy, Vapi, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3742-48

3742-48

1522

499

23.

EVALUATION OF IMMUNOMODULATORY ACTIVITY OF POLYSACCHRIDE FRACTION OF INULA RACEMOSA, BOMBAX CEIBA AND ALLIUM SATIVUM

Inula racemosa, Bombax ceiba and Allium sativum are important class of drug known as “Rasayana”. The Polysaccharide fraction of all the three Drugs was isolated from hot water extraction yielding about 50-60% of fructan fraction (Polysaccharide). The polysaccharide fraction was evaluated for immunomodulatory activity by antibody titer and cellular immune response. The immunosuppressant drug az...

Ashish Mishra *, Mayank Thakur and Shashi Alok

Advance Institute of Biotech and Paramedical Sciences, Kanpur, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3749-55

3749-55

1528

412

24.

SALVIA VIRGATA JACQ. AND SILIBUM MARIANUM L. GAERTN DISPLAY SIGNIFICANT IRON-CHELATING ACTIVITY

In some disease like thalassemia major long-term transfusion alone inexorably produces the clinical problem of iron overload. Danshen and Milk thistle has been widely prescribed in traditional folk medicine for treatment of liver diseases. In this study we selected eight medicinal plants whose efficiencies had been previously demonstrated in treatment of liver diseases in ancient medicine were stu...

Md. Ali Ebrahimzadeh, Masoumeh Khalili*, Mohammad Azadbakht and Masoud Azadbakht

Pharmaceutical Science Research Center 1, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

DOI: 10.13040/IJPSR.0975-8232.7(9).3756-63

3756-63

1508

496

25.

FORMULATION AND CHARACTERIZATION OF DILTIAZEM HYDROCHLORIDE MATRIX TABLETS BY USING NATURAL POLYMERS

The purpose of present study was to design and evaluate matrix tablets of Matrix tablets of Diltiazem hydrochloride were prepared by using natural polymers like Gum karaya and Gum kondagogu. The pre formulation study was performed on combination of drug with polymers by FTIR suggested that drug and polymers were compatable. The matrix tablets were prepared by using by wet granulation method. ...

P. Dwarakanadha Reddy *, D. Vijaya Bharathi, D. Swarnalatha and C. Gopinath

Annamacharya College of Pharmacy, Rajampeta, Kadapa, Andhrapradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3764-69

3764-69

1489

480

26.

DEVELOPMENT AND IN-VITRO CHARACTERISATION OF ORAL SUSTAINED RELEASE MATRIX TABLETS OF GEMIGLIPTIN

This project involves in the development of sustained release matrix tablets of Gemigliptin. Which is an oral anti-hyperglycemic agent designed for the management of non insulin dependent diabetes mellitus (NIDDM). The basic goal of therapy is to achieve a steady sate blood level that is therapeutically effective and non toxic for an extended period of time. The objective in dosage form design is ...

Srinivas Martha*, CH. Sagarika, K. Nandini, V. Seshavardhan and M. Kranthi kumar

Department of Pharmaceutics, Joginpally B.R. Pharmacy College, Yenkapally (V), Moinabad (M), Hyderabad- 500075, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3770-80

3770-80

1502

460

27.

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF CELIPROLOL HYDROCHLORIDE IN TABLET FORMULATION

Simple, specific, accurate and cost economic UV spectrophotometric methods were developed and validated for determination of Celiprolol Hydrochloride. Instead of using organic solvents, mixture of dilute hydrochloric acid and water was used during method development and validation. The drug was extracted from tablet formulation with a mixture of water and hydrochloric acid. Stability of drug solut...

Manisha Chavan* and Manisha Sutar

Alard College of Pharmacy, Hinjewadi, Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3781-86

3781-86

1674

409

28.

VENOUS THROMBOEMBOLISM PROPHYLAXIS IN MEDICAL INPATIENTS AND ADHERENCE TO GUIDELINE RECOMMENDATIONS: A PROSPECTIVE STUDY

Background: Venous thromboembolism (VTE) is a common complication during and after hospitalization for medical patients. Previous studies have shown that only about one third of high risk medical patients receives VTE prophylaxis. Guidelines such as the one produced by the American college of Chest Physicians (ACCP) are aimed at reducing hospital associated VTE. The objective of this study was to ...

Elham Kalantari, Sarah Mousavi *and Atieh Aliyar Samani

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

DOI: 10.13040/IJPSR.0975-8232.7(9).3787-93

3787-93

1924

392

29.

EVALUATION OF ANTIFERTILITY ACTIVITY OF ACHYRANTHUS ASPERA LEAVES IN FEMALE MICE

Present study was conducted to know the antifertility potential of Achyranthus aspera leaves in female mice and has shown promising results of antiovulatory activity, estrogenic and constant teratogenic activities. Administrations of A. aspera leaves methanolic extract at the dosage 25 mg/kg and 50 mg/kg body weight were subjected for testing their antiovulatory, estrogenic and teratogenic activit...

Chinnappa Reddy V., Abhay Kumar Kamble and Sharangouda J. Patil *

Edutel Technologies Private Limited, Yeshwantpur Industrial Subrub, Yeshwantpur, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3794-01

3794-01

1537

431

30.

MOLECULAR DOCKING AND SITE DIRECTED MUTAGENIC APPROACH TO INVESTIGATE THE ROLE OF trp86 OF HUMAN ACETYLCHOLINESTERASE WITH ORGANOPHOSPHATES

Docking and site directed mutagenesis approach was used to explore mode of binding and inhibition for human acetylcholinesterase (hAChE) and organophosphates (OPs). More than 200 OP molecules were investigated using Glide docking module of Schrodinger suit as co-crystal structure between two are not available in Protein Data Bank. In initial screening Trp86 was found to be involved in maximum Pi-C...

Anuj Ranjan*, Saradindu Ghosh, Abhishek Chauhan and Tanu Jindal

Amity Institute of Environmental Toxicology, Safety and Management, Amity University, Noida, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3802-09

3802-09

1732

512

31.

UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF DICLOFENAC SALT AND EPERISONE HYDROCHLORIDE IN BULK AND CAPSULE DOSAGE FORM

The present paper describes a new, simple, accurate, environmentally friendly, economic spectrophotometric method for simultaneous estimation of Diclofenac salt and Eperisone HCl in bulk and Capsule Dosage Form. Acetate buffer pH5.5 was used as solvent. The wavelength selected for analysis is 276nm & 261.20nm for estimation of Diclofenac Salt and Eperisone HCl respectively. Beers law was obeye...

Kiran K. Dhokale*, Deepak D. Deore and Madhuri A. Nagras

Sinhgad College of Pharmacy, Department of Quality Assurance Techniques, Vadgaon (Bk.), Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3810-14

3810-14

2251

548

32.

EVALUATION OF MINIMUM INHIBITORY CONCENTRATION OF CHLORAMPHENICOL FOR SALMONELLA SPP. ISOLATED FROM ENTERIC FEVER CASES IN A TERTIARY HOSPITAL IN IMPHAL

Chloramphenicol was introduced as the effective antibiotic in the treatment of typhoid fever. Resistance started to develop within two years of its introduction. The emergence of antibiotic resistant strains of bacteria is closely linked to the irrational use of antibiotics. The sensitivity/resistance pattern of Salmonella spp. had been varying with time and geographical locations. Changing trends...

K. M. Sania*, P. D. Shyamasakhi, K. D. Krishna Pramodini and K. D. Sulochana

Senior Resident C/O Department of Pharmacology Regional Institute of Medical Sciences, Imphal, Manipur, India.

DOI: 10.13040/IJPSR.0975-8232.7(9).3715-19

3715-19

2344

554

33.

EFFECTIVENESS OF ANTIBIOTICS IN INCREASING THE FUNCTIONAL CAPACITY AND REDUCING THE ECONOMIC BURDEN IN FEMALE URINARY TRACT INFECTION PATIENTS

Background: Urinary tract infection is a common medical problem for women throughout their lifetime. Recurrence after urinary tract infection (rUTI) is common in adult women. The majority of recurrences are believed to be reinfection from extra urinary sources such as rectum or vagina. The treatment of recurrent urinary tract infection also inflicts an economic burden on the patient’s life. Henc...

Sam Johnson Udaya Chander J. , S. Ramya and A. Anandhasayanam *

Department of Pharmacy Practice, JKKMMRF College of Pharmacy, Vattamalai, Komarapalayam, TN, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3820-25

3820-25

1456

371

34.

PREVALENCE OF OBESITY AND ITS LINK BETWEEN VARIOUS DISORDERS IN A SEMI URBAN DISTRICT IN KERALA

Overweight and obesity rates have been increasing sharply over recent decades in all industrialized countries, as well as in many lower income countries. According to the WHO World health statistics report 2012, globally one in six adults is obese and nearly 2.8 million individuals die each year due to overweight or obesity 1. Obesity is a close marker of important aspects of individual life style...

A. Anandhasayanam *, S Kannan, Mohammed Dinsar and P Saranya

Department of Pharmacy Practice, JKKMMRFs AJKKSA College of pharmacy, Komarapalayam Po, Erode, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3826-34

3826-34

1657

528

35.

EVALUATION OF DRUG UTILIZATION PATTERN IN INDOOR PATIENTS OF MEDICINE DEPARTMENT AT TERTIARY CARE TEACHING HOSPITAL IN SOUTHERN RAJASTHAN

Aims: To study and evaluate the pattern of drug utilization by using WHO/ INRUD indicators in medicine indoor patients. Methodology: A prospective cross sectional observational study was done on patients admitted in medicine indoor. Information regarding age, gender, occupation, income group, diagnosis, patient’s present/past medical history, number of days of hospitalization, treatment, any ADR...

Vimlesh Kumar Meena, Meena Atray * and Apruva Agrawal

Department of Pharmacology, R.N.T. Medical College, Udaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3835-40

3835-40

2553

579

36.

PROPORTION OF THYROID DISEASES IN JHARKHAND

Thyroid disorders are an important public health issue in India and across worldwide. Earlier it has been reported that around 42 million people in India are suffering from thyroid disease. Although easy to detect and not very expensive to treat, this disease often remain undetected and untreated and thus affects other systems of the body. Studies from various research workers discuss the proporti...

Anupa Prasad, Tannu Kumari *, Kaushal Kishore Sinha and Meetu Laxmi Giri Bharti

Biomedical Informatics Centre (ICMR), Department of Biochemistry, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3843-47

3843-47

1739

541

37.

DIFFERENCE BETWEEN NATIVE AND MUTANT RHIZOBIUM ON GROWTH OF VIGNA MUNGO L.

The present study, carry out the use of plant growth promoting rhizobacteria, were used to improve the yield in crop. The Rhizobium strains isolated from legumes plant Mimosa pudica L and this strain was mutated by using UV radiation. The plant growth hormones were detected by native as well as mutant Rhizobium strains by paper chromatography techniques. The same strains use in conducted to green ...

Shijila Rani AS, P. Parthiban * and V. Mahesh

Department of Microbiology, Marudupandiyar College, Vallam, Thanjavur, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3848-51

3848-51

1470

559

38.

ANTICANCER ACTIVITY OF METHANOLIC EXTRACTS OF SELECTED MANGROVE PLANTS

Anti cancer activity of four selected mangrove plants Bruguiera gymnorrhiza, Aegiceras corniculatum, Aegialitis rotundifolia and Lumnitzera racemosa against HepG2 cell line was studied. During the present investigation, crude methanol extracts of selected mangrove plants were prepared using soxhlet apparatus. In vitro anti cancer activity of mangrove plant extracts at various concentrations (10 to...

A. R. K. Reddy * and J. Ratna Grace

M.Sc Biotechnology, Centre for Research, Dr. V.S. Krishna Govt. Degree & P.G College (A), Maddilapallem, Visakhapatnam, Andhrapradesh - 530013, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3852-56

3852-56

2700

785

39.

ANTIHAEMOLYTIC ACTIVITY OF PHYTOCHEMICAL AQUEOUS EXTRACTS OF PTEROCARPUS SANTALINUS AND PHYLLANTHUS EMBLICA IN RED BLOOD CELLS OF HUMAN SUBJECTS RECEIVING CHRONIC ALCOHOL AND CIGARETTE SMOKING

Medicinal plants are natural gift to human lives to promote disease free healthy life. Worldwide believe that herbal remedies are safer and less damaging to the human body than synthetic drugs. The heartwood of Pterocarpussantalinus (PSB) and the fruit of Phyllanthusemblica (PEF) are important medicinal parts with several ethnomedicinal properties. Keeping in view their importance, this work was c...

T. Lokesh, B. Sarada , K. Swarnalatha , M Abdul Kareem, N.CH. Varadacharyulu *

Department of Biochemistry, Sri Krishnadevaraya University, Anantapuramu, AP, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3857-64

3857-64

1847

528

40.

EFFECT OF COMBINED VITAMIN E SUPPLEMENTATION AND TREADMILL EXERCISE ON SPECIFIC HAEMATOLOGICAL PARAMETERS OF THE SEDENTARY UNIVERSITY STUDENTS

Background: Hemoglobin in the blood carries oxygen from the respiratory organs (lungs or gills) to the rest of the body (i.e. the tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power the functions of the organism in the process called metabolism. Several research studies have pointed out the role of vitamin supplementation and amelioration from exercise i...

Salman Farsi Mondal and Pathikrit Bandopadhyay *

Department of Physical Education, Kalyani University, Kalyani, Nadia, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3865-70

3865-70

1466

427

41.

EFFECTIVENESS OF TENDER COCONUT WATER (COCOS NUCIFERA L) AGAINTS PARASITEMIA INDEX AND HEMOGLOBIN LEVELS IN MALARIA INFECTION

Red blood cells (RBCs) is the primary target of human Plasmodium. Species. Occurs oxidative stress on uninfected and infected RBC and lead to hemoglobin (Hb) level decreased. The mechanism of decreased hemoglobin level are reduced survival time, diserythropoiesis and increased erythrolysis. Ascorbic acid and phenolics of TCW effectives to prevent RBCs from oxidative damage. Methods: The post test ...

Mulyanti *, Edi Dharmana, Kis Djamiatun and Noor Wijayahadi

Magister of Nutrition Science, Medical Faculty of Diponegoro University and researcher in Master of Biomedical Science, Java, Indonesia

DOI: 10.13040/IJPSR.0975-8232.7(9).3873-76

3873-76

2209

455

42.

STUDY OF THYROID DYSFUNCTION IN TYPE II DIABETES MELLITUS

Diabetes Mellitus (DM) has emerged as a common endocrine disorder in the world and the prevalence of thyroid dysfunction is increasing at the same time. The thyroid hormones control insulin secretion. In hypothyroidism there is a reduction in glucose-induced insulin secretion by beta cells, and during thyrotoxicosis the insulin resistance will be increased. Type 2 diabetes mellitus patients with s...

Sarguru Datchinamoorthi *, Naveena Rathanavel, Balaji Rajagopalan and R. Vanaja

Department of Biochemistry, Shri Sathya Sai Medical College and Research Institute, Chennai, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.7(9).3877-80

3877-80

2631

597

43.

PROFILE AND AWARENESS OF BLOOD DONORS: A STUDY IN BLOOD BANK OF A TERTIARY CARE HOSPITAL OF KOLKATA

Introduction: Blood is the only oxygen transporter in the body and is crucial in saving lives. Research has failed to find a true substitute for blood and blood components The attitude, beliefs, and level of knowledge associated with blood donation will determine whether potential donors will donate blood or not. Methodology: A descriptive epidemiological study with cross sectional study design wa...

Sinjita Dutta*, Debasish Sinha, Sita Chatterjee, Mausumi Basu and R. N. Misra

Department of Community Medicine, IPGME & R, Kolkata West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3881-86

3881-86

2414

558

44.

PLATELET DERIVED GROWTH FACTOR IN DIABETIC LOWER EXTREMITY ULCER: A RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED STUDY IN INDIAN CONDITION

Background-In September 2012, the world health organization reported a global prevalence of diabetes exceeding 300 million people, predicting a further 60-70% increase by the year 2030, which means India alone will have 100 million people by year 2030. Wound healing is problematic in diabetic patients. Encouraging results have shown that PDGF application is better than good wound care alone. But t...

Abhishek Samuel *, Anupam Mahajan, Maharaj K. Mam and Jeewan S. Prakash

Department of Orthopaedics, Christian Medical College, Ludhiana, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3887-92

3887-92

1960

491

45.

EVALUATION OF LEVOFLOXACIN VS. NORFLOXACIN; EFFECT ON BLOOD GLUCOSE PROFILE IN ALLOXAN INDUCED DIABETIC ALBINO RATS- A COMPARATIVE STUDY

Flouroquinolones (FQ) used commonly for treatment of community and hospital-acquired infections, has been prefixed with multiple adverse effects. Amongst them the glycemic variability has been attention seeking. Drug induced dysglycemia can be acute or persistent and severe too. The present study is designed to evaluate and compare the actions of Levofloxacin vs. Norfloxacin in altering blood gluc...

A. Acharya *, S. S. Halemani and P. Adake

Department of Pharmacology, Subbaiah Institute of Medical Sciences, Shimoga, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3893-98

3893-98

2147

452

46.

A NEW PERSPECTIVE FOR THE TREATMENT OF DANDRUFF & ASSOCIATED ALOPECIA WITH EMULSION BASED GEL CONTAINING KETOCONAZOLE AND MINOXIDIL

Many antifungal drugs are used topically in order to treat fungal diseases. Among them Ketoconazole is used widely among these topical antifungal drugs for eradication of dandruff. Scalp with dandruff causes more hair fall than normal scalp and hair fall is treated by topical Minoxidil formulation. Aim of present work is to prepare a topical formulation containing both ketoconazole and minoxidil i...

Mahima Singh *, A.G. Hariharan, C. K. Sudhakar and Sanjay Jain

Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(9).3899-06

3899-06

1972

478