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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 9 (2018) - Issue 2, February

Review Articles

 
Title
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1.

NEW ADVANCEMENTS OF BIOPLASTICS IN MEDICAL APPLICATIONS

The bio-plastics that are produced either from fossil material or can be synthesized from biomass or renewable resources, such as Poly-lactic acid (PLA), Polyethylene glycol (PEG) and Poly - ε - caprolactone (PCL) are been reported as a material of choice for biomedical applications due to their good physical properties such as crystallinity, storage modulus, glass transition temperature and bior...

K. Bano, R. Pandey, Jamal-e-Fatima and Roohi*

Protein Research Laboratory, Department of Bioengineering, Integral University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).402-16

402-416

4084

1042

2.

AN OVERVIEW OF DANDRUFF AND NOVEL FORMULATIONS AS A TREATMENT STRATEGY

This review gives an insight of the scalp condition- dandruff which affects more than 50% of the human population. Malassezia furfur is reported as the main cause of dandruff. This article aims at investigating other causes of dandruff which include microbial and non - microbial factors. These factors have been explained in this article. It also highlights the various treatment options and newer f...

M. Narshana*and P. Ravikumar

Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).417-31

417-431

3751

1178

3.

MEDICINAL USE OF AN ANCIENT HERB MOMORDICA CYMBALARIA: A REVIEW

Momordica cymbalaria (Hook, Fenzl) is a vine of Momordica genus found in the Indian states of Karnataka, Madhya Pradesh, Maharashtra, Andhra Pradesh and Tamil Nadu. The medicinal herb also been named Luffa tuberose (Roxb) or Momordica tuberose (Roxb). Momordica cymbalaria is commonly known as Karchikai (Kannada) or Athalakkai (Tamil) or Kasarakayee (Andhra Pradesh) and Kakrol (India). Momordica cy...

D.K. Jha*, R. Koneri and S. Samaddar

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).432-41

432-441

2407

742

4.

MITOCHONDRIA – TARGETED ANTIOXIDANT: AGING

The mitochondrion, the “power house of cell”, plays a central role in energy-generating processes so called as ‘‘master of life and death’’. A decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders. With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to accumulation of mutations and ...

B. Varghese*, N. L. Gowrishankar, K. Drisya and M. T. Ramees

Department of Pharmaceutical Analysis, Prime College of Pharmacy, Palakkad, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).442-55

442-455

2588

540

5.

AN UPDATED PHARMACOLOGICAL ACTIVITY OF COCCINIA INDICA (WIGHT & ARN.)

Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules. Coccinia indica belongs to the family Cucurbitaceae. It is a rapidly growing, perennial climber or trailing vine. Traditionally different parts of this plant namely the roots, leaves and fruits are used in folklor...

M. Kumar*, S. Alok, D. K. Chanchal, R. K. Bijauliya, R. D. Yadav and M. Sabharwal

Department of Pharmacognosy , Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).456-65

456-465

1804

580

Research Articles

 
Title
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6.

DESIGN AND EVALUATION OF CHITOSAN-BASED MICROPARTICLES AS MODELS OF PROTEIN DELIVERY SYSTEMS

Controlled release systems for protein and peptide vaccines based polymers have been considered for many applications in medical therapies. Chitosan is non-toxic and easily absorbed biopolymers and is often used in many researches to sustained release drugs and proteic vaccines. This study investigates the kinetics of release in vitro of bovine serum albumin (BSA) from chitosan microparticles and ...

L. V. Barros-Lima, M. E. F. A. G. Oliveira and R. V. S. Amorim*

Programa de Pós-graduação em Morfotecnologia - Departamento de Histologia e Embriologia - UFPE, Centro de Biociências - Cidade Universitária, Recife, PE, Brazil.

DOI: 10.13040/IJPSR.0975-8232.9(2).466-74

466-474

1321

510

7.

T-CELL ACTIVATION CONTROLLING EFFECTS OF ETHYL ACETATE FRACTION OF KALANCHOE PINNATA (LMK) PERS ON TMPD-TREATED LUPUS MICE

T-cell activation, with the low expression of CD62L (L-selectin) marker in the spleen, will increase B cell activity to produce lupus antibodies. Therefore, lupus patients need drugs which could increase the L- selectin expression in the spleen to reduce the auto-reactive T cell. The tested drug to increase the L-selectin in this research was the ethyl acetate fraction of Kalanchoe pinnata (Lmk) P...

N. Indriyanti, J. Soeroso and J. Khotib*

Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Jl. Dharmawangsa Surabaya, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.9(2).475-82

475-482

1175

497

8.

EVALUATION OF HISTO-PATHOLOGICAL CHANGES IN THE MICE EXPOSED TO SODIUM NITRITE FOR LONG TERM BY USING HEMATOXYLIN AND EOSIN STAINING

Objective: The aim of this study is to investigate whether exposure to subclinical dose of sodium nitrite for long term can trigger histopathological changes which are able to detect by using hematoxylin and eosin stain. Sodium nitrite has various properties that make it widely used in industrial and pharmaceutical fields.  Method: Three groups of mice were used in this study; the first group was...

S. M. A. Al-Hiti*, A. H. M. Hussain and A. A. F. Al-Zabaidy

Department of Pharmacology and Toxicology, Pharmacy College, University of Baghdad, Iraq.

DOI: 10.13040/IJPSR.0975-8232.9(2).483-89

483-489

1164

445

9.

STUDIES ON PHYTOCHEMICAL SCREENING – GC-MS CHARACTERIZATION, ANTIMICROBIAL AND ANTIOXIDANT ASSAY OF BLACK CUMIN SEEDS (NIGELLA SATIVA) AND SENNA ALEXANDRIA (CASSIA ANGUSTIFOLIA) SOLVENT EXTRACTS

As science encourage most of the medicinal plants as supreme source of unlimited chemical compounds which are of great interest in pharmacological preparations. The present investigation was aimed to study Nigella sativa seeds and Cassia angustifolia leaf solvent extract (petroleum ether, methanol and aqueous solutions) for phytochemical screening, GC-MS characterization, Antimicrobial and Antioxi...

S. H. Reddy*, A. S. Al-Kalbani and A. S. Al-Rawahi

Applied Biology Section, Department of Applied Sciences, Higher College of Technology, Al-Khuwair, Muscat, and Sultanate of Oman.

DOI: 10.13040/IJPSR.0975-8232.9(2).490-97

490-497

1392

650

10.

SYNTHESIS OF BENZO[G]QUINOXALINE-5,10-DIONE BASED PYRAZOLINE DERIVATIVES AND THEIR ANTIMYCOBACTERIAL ACTIVITY

Eleven new compounds belonging to series 7-[5-(substituted) phenyl - 4, 5-dihydro-1H-pyrazol-3-yl]-2,3-diphenyl-5H, 10H - benzo[g] quinoxaline - 5, 10 - dione  (Compound 7a-k) were synthesized by multistep synthetic scheme. The newly synthesized compounds were screened for their in-vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv by L.J. Slope (Conventional) Method. Compo...

S. Kumar *, N. Kumar and S. Drabu

Department of Pharmacy, Government Polytechnic, Uttawar, Palwal, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).498-08

498-508

1260

545

11.

DNA- BINDING AND CLEAVAGE STUDIES OF Mn(II) AND Co(II) COMPLEXES OF 1-(2,5-DIOXOPYRROLIDIN-1-YL)(4-HYDROXY PHENYL)METHYL) THIOUREA)

A novel Mannich base ligand 1-(2,5-dioxopyrrolidin-1-yl) (4-hydroxy phenyl)methyl)thiourea (PSTU) and its Manganese (II) and Cobalt (II) complexes have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, FT-IR, 1H NMR and 13C NMR spectroscopic studies. The antimicrobial activities and antioxidant activities of the free lig...

S. Sudhasankar*, M. Vijayachandrasekar, A. Natarajan and S. R. K. Pandian

Department of Chemistry, SRM University, Kattankulathur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).509-16

509-516

759

315

12.

STUDIES ON ANTI-INFLAMMATORY EFFECT OF MESUA FERREA LINN. IN ACUTE AND CHRONIC INFLAMMATION OF EXPERIMENTAL ANIMALS

Mesua ferrea Linn. (M. ferrea) is an endemic medicinal plant used for the treatment of inflammation, rheumatism, bronchitis, fever, headache, asthma and skin diseases. The aim of this study was to investigate the anti-inflammatory activities of 80% ethanol extract from stem bark of Mesua ferrea Linn. using animal models. Female Wistar albino rats weighing (150-200g) were used for the study. Anti-...

R. Prathima, H. Manjunatha*, V. Krishna, S. Kandagalla and B. S. Sharath

Department of PG Studies and Research in Biotechnology and Bioinformatics, Kuvempu University, Shimoga, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).517-25

517-525

867

333

13.

ANTIOXIDANT AND LIPID LOWERING EFFECTS OF ELAEOCARPUS GANITRUS IN CHOLESTEROL FED RABBITS

Elaeocarpus ganitrus Roxb. is reported to exhibit multifarious pharmacological activities. However no scientific study has been conducted to evaluate antiatherosclerotic /lipid lowering activity of E. ganitrus Roxb. The present study was designed to investigate the antihyperlipidaemic and antioxidant activity of 70% ethanolic extract of E. ganitrus seed (EGEE) in cholesterol fed hyperlipidaemic ra...

P. K. Jain, P. Sharma and S.C. Joshi*

Reproductive Toxicology Unit, Center for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).526-34

526-534

741

308

14.

GC-MS ANALYSIS OF CALLUS AND LEAF EXTRACTS OF IN VITRO PROPAGATED PLANTS OF JUSTICIA WYNAADENSIS (NEES) T. ANDERSON

The present study was aimed at induction of callus, micropropagation of Justicia wynaadensis (Nees) T. Anderson in vitro by using different explants and study of the phytocomponents present in the aqueous and methanol extracts of callus and leaf of in vitro propagated plants through GC-MS analysis. Callus was induced using MS basal medium supplemented with combinations of 2, 4-D, IAA and NAA growt...

C. D. Vandana*, K. N. Shanti and S. L. Shantha

Department of Biotechnology, PES Institute of Technology, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).535-43

535-543

955

375

15.

BISPHENOL A ENHANCES GROWTH OF Hep-G2 CANCER CELLS BY UPREGULATING EXPRESSION OF PRO – INFLAMMATORY AND PRO – ANGIOGENESIS PROTEINS

Bisphenol A (BPA) is primarily used in the manufacture of plastics and resins. There are many scientific reports that point to the adverse effects of this chemical to different animal models. There has been an increase in use of plastic during the last couple of decades and this has increased human exposure to plasticizers like Bisphenol A. But since little is known on how these endocrine disrupto...

D. B. Menon*and M. S. L. Dev

Centre for Evolutionary and Integrative Biology, University of Kerala, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).544-49

544-549

839

284

16.

THERAPEUTIC POTENTIAL OF CUCURBITS AGAINST RADIATION INDUCED INFLAMMATION AND DAMAGE IN MICE GUT

Whole body or local irradiation to gut is known to induce significant damage to gut epithelium and crypt stem cells. A large population of microbes in the gut remains unaffected. We hypothesize that the modifications in diet and enteric microbial population may provide a non-toxic mechanism to counter radiation induced health deficit, especially in the gut and therefore investigated the effect of ...

S. Chauhan, D. Sharma and H. C. Goel*

Amity Centre for Radiation Biology, Amity University Uttar Pradesh (AUUP), Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).550-62

550-562

722

237

17.

DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL ANTI-TUBERCULAR AGENTS TARGETING GLUTAMINE SYNTHETASE-1 AND CYCLOPROPANEMYCOLIC ACID SYNTHASE-2

The World Health Organization 2015 (WHO) reports indicate that there were 9.0 million new tuberculosis (TB) cases and 1.5 million tuberculosis (TB) deaths during 2015. Co-infection with the HIV fuels the global TB crisis, and successful TB treatment is further complicated and hampered by the existence of multidrug- resistant (MDR) TB and extensively drug resistant (XDR) TB. Hence there is an urgen...

J. Suresh*, S. G. Lakshmi, K. Madhesh, B. Karunya, K. M. Noorulla and P. R. Surya

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Affiliated to the “The Tamil Nadu Dr. M.G.R Medical University”, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).563-74

563-574

846

394

18.

EVALUATION OF IN VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF CASSIA AURICULATA LINN. EXTRACTS

Objective: To evaluate in vitro antioxidant and anti-inflammatory activity of Cassia auriculata leaf extracts. Methods: Herbal extraction was done by Soxhlet extraction method with increasing polarity of Solvents viz., Chloroform, Ethanol, Methanol. Phytochemicals analysis was done using different biochemical tests. Antioxidant potential of plant extracts were analyzed by ferric ion reducing antio...

J. B. Uppin, V. M. Chandrasekhar and G. R. Naik*

Department of Studies in Biotechnology, Gulbarga University, Gulburga, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).575-81

575-581

827

301

19.

STUDIES ON AN ANTI-AGING FORMULATION PREPARED USING ALOE VERA BLENDED COLLAGEN AND CHITOSAN

Photochemoprotection has nowadays become inevitable to combat aging. Exposure to Ultraviolet radiations accelerates skin aging which eventually culminates in wrinkles, laxity, dyspigmentation, roughness and dryness. Though many active synthetic topicals have been used since years, the present era of treating an aged skin has been diverted towards natural biomaterials as these synthetic topicals po...

S. Rajashree and C. Rose*

Department of Biotechnology, CSIR- Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).582-88

582-588

1306

403

20.

EFFECT OF TRANS – ESTERIFICATION OF OIL ON NANOEMULSION GEL FOR TOPICAL DRUG DELIVERY

The research investigated the modification of nano-emulsion by using transesterfied soyabean oil, to enhanced solubility and diffusion of voriconazole. Ternary phase diagrams of soyabean oil, acid / base esters of soyabean oil, Tween 80: PEG 400 (S/CoS) and water were developed. Ester value of soyabean oil increased from 214.04 to 261.5mg KOH/1g for acid ester and 293.58mg KOH/1g for base ester co...

A. A. Chikte, M. J. Umekar, M. N. Borkhade and N. S. Raut*

Department of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar, College of Pharmacy, Kamptee, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).589-98

589-598

793

330

21.

STABILITY INDICATING RP-HPLC METHOD FOR COMBINATION OF PSEUDOEPHEDRINE SULPHATE AND LORATADINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION

Reverse Phase - High performance liquid chromatographic (RP - HPLC) method was described for determination of Pseudoephedrine Sulphate (PSE) and Loratadine Hydrochloride (LOR). The chromatographic separation was achieved using mobile phase mixture of Acetonitrile: 0.05 M Potassium Dihydrogen Phosphate Buffer: (pH 2.8 adjusted with Ortho Phosphoric Acid Solution): Methanol in the ratio of 30:35:35 ...

E. A. Sharma*and N. J. Shah

Quality Assurance Department , School of Pharmacy, RK University, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).599-07

599-607

859

239

22.

ANTIOXIDANT ANALYSIS AND ENZYME INHIBITION ASSAY OF PLANTS OF APOCYNACEAE FAMILY FOR ULCERS

Different plants of the Apocynaceae family viz. Alstonia scholaris, Calotropis procera, Rauvolfia serpentine, Hemidesmus indicus and Calotropis gigantean are traditionally being reported in ulcers treatments. The present study was aimed to validate the authenticity of correlationship of various phytoconstituents concentrations, antioxidant activity and urease inhibitory potential of the same. Vari...

N. Sikri and S. Dalal*

Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).608-16

608-616

944

299

23.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF BENZIMIDAZOLE DERIVATIVES

Benzimidazoles are an important class of compounds with a wide spectrum of biological activity ranging from anti-hypertensive, anti-viral, anti-fungal, antitumor and anthelmintic activity. Benzimidazole rings are the most important nitrogen-containing heterocycles, which are widely explored and utilized by the pharmaceutical industry for drug discovery. Due to their special structural features and...

K. Anand* and S. Wakode

Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).617-24

617-624

1053

394

24.

ALKALINE DEGRADATION KINETICS AND STABILITY INDICATING RP-HPLC METHOD FOR THE ESTIMATION OF FLAVOXATE HYDROCLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

A simple stability indicating reversed-phase HPLC method was developed, validated and subsequently alkaline degradation kinetics are also determined for the estimation of Flavoxate Hydrocloride (FVH) present in pharmaceutical dosage forms. The proposed RP-HPLC method utilizes a LiChroCART - Lichrosphere 100, C18 RP column Hibar® (250 × 4 mm, 5 μm) in an isocratic separation mode with mobile pha...

K. S. Rao

Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).625-32

625-632

736

254

25.

DEVELOPMENT AND IN VITRO EVALUATION OF SELF EMULSIFYING FORMULATION FOR EMBELIN

The purpose of present work was to improve the oral bioavailability of embelin by formulating this hydrophobic phytoconstituent as self emulsifying drug delivery system (SEDDS). SEDDS improves the oral bioavailability by overcoming the dissolution step, enzymatic degradation and hepatic first pass metabolism of phytoconstituent. On the basis of solubility study of embelin, ethyl oleate, tween 80 a...

Neeraj*, V. Mittal and A. Nanda

Department of Pharmaceutical Science, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).633-41

633-641

744

345

26.

1-[3/-(SUBSTITUTED PHENYL) -5/- (AMINO PYRIMIDINE)]- 3- (4/-NITRO PHENYL) 5-(SUBSTITUTED PHENYL)- 2-PYRAZOLINES: SYNTHESIS, CHRACTERISATION AND ANTIMICROBIAL SCREENING

In the present study eight novel 2-pyrazoline - amino pyrimidine hybrids have been synthesized in order to search new chemical entities with increased pharmacological properties. The targeted analogues were synthesized in four steps; Claisen-schmidt condensation of 4-nitro acetophenone with different benzaldehydes in basic medium to yield precursor chalcone which was cyclised using hydrazine hydra...

Y. A. Hatwar

Department of Chemistry, Rajiv Gandhi College of Engineering, Research and Technology, Chandrapur, Gondwana University, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).642-49

642-649

762

320

27.

AN EFFICIENT, GREENER MICROWAVE ASSISTED MULTI-COMPONENT ONE POT SYNTHESIS OF [1, 3, 4] THIADIAZIN-2-YL-THIAZOLIDIN-4-ONES

This work involves synthesis of [1, 3, 4] thiadiazin-2-ylamine 3(a-c) derivatives from various substituted acetophenone derivatives 1(a-c), and thiosemicarbazide 2 mixed in ethanol and irradiation with microwaves which were directly used for next step. [1, 3, 4]Thiadiazin-2-yl)-thiazolidin-4-one 6(a-f) were synthesized in the second step from substituted-6H-[1, 3, 4] thiadiazin-2-ylamine 3(a-c), s...

S. R. Dhongade* and S. A. Kenawade

Research Laboratory in Heterocyclic Chemistry, Devchand College, Arjunnagar Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).650-55

650-655

671

308

28.

FORMULATION AND EVALUATION OF DILTIAZEM HCl FAST DISSOLVING TABLETS USING DIFFERENT CO-PROCESSED EXCIPIENTS BY DIRECT COMPRESSION METHOD

The aim of present work was to prepare Diltiazem HCl Fast Dissolving tablets by Direct compression method because of their convenience in administration and suitability for patients having dysphagia using Co-processed excipients - Disintequik MCC25, Disintequik MCC, Lubritose MCC, Lubritose SD, Lubritose AN, NF Fast flo Lactose Monohydrate modified spray dried. The Prepared powdered blend and tabl...

M. S. Reddy*, N. Kore and S. M. Fazal Ul Haq

Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).656-64

656-664

706

358

29.

NEUROPROTECTIVE PROPERITY OF CENTELLA ASIATICA AGAINST PENTYLENE- TETRAZOLE INDUCED EPILEPSY IN RAT BRAIN WITH PARTICULAR REFERENCE TO LIPID METABOLISM

This study evaluated the anticonvulsant effect of different extracts of Centella asiatica (CA) with particular reference to lipid metabolism in different regions of rat brain. The rats were randomly divided into 4 groups having 6 in each group: i.e. Control group received saline, PTZ-induced  epileptic group (60mg/kg  b.w op/ 1 day), epileptic  group pretreated with  chloroform extract  (CE),...

K. S. Prasad

Department of Zoology, SVSSC Government Degree College, Sullurpet, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).665-71

665-671

907

294

30.

EFFECT OF HIGH ENERGY BALL MILLING GRINDING ON PHYSICO-CHEMICAL, MORPHOLOGICAL AND OPTICAL PROPERTIES OF CURCUMA LONGA NANOPARTICLES POWDERS

Curcuma longa nano powder was prepared by high energy ball milling equipment using green synthesis. Green synthesis is the process of synthesizing nanoparticle from biogenic resources based on the fact of its bioactive potential would be less toxic (product & bi-product), environmental safety (eco-friendly and biodegradable) cost effective and easily available to its natural origin. The powder...

A.K. Aman, R. K. Singh*, R. Kumar and A. K. Ghosh

Aryabhatta Centre for Nanoscience and Nanotechnology, Aryabhatta Knowledge University Patna, Bihar, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).672-77

672-677

940

322

31.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING UV SPECTRO-PHOTOMETRIC METHOD FOR THE ESTIMATION OF BENZYDAMINE HYDROCHLORIDE IN BULK AND IN PHARMACEUTICAL DOSAGE FORM: A NOVEL ANALYTICAL TECHNIQUE FOR CONDUCTING IN-VITRO QUALITY CONTROL TESTS

The objective of the present study is to develop and validate a novel stability indicating UV spectrophotometric method for estimation of Benzydamine Hydrochloride (BNZ) in pharmaceutical dosage form as not a single UV spectrophotometric method has been reported for the estimation of Benzydamine Hydrochloride, which makes the present work novel. In the present research work, UV spectrophotometric ...

D. Sharma*, R. Singh and R. Garg

I. K. Gujral Punjab Technical University, Kapurthala, Punjab India.

DOI: 10.13040/IJPSR.0975-8232.9(2).678-86

678-686

1158

345

32.

THE HYPOXIC VENTILLATORY RESPONSE AND HEPATIC CYP3A4 UPREGULATION IN HUMAN AT HIGH ALTITUDE

The Hypoxic Ventillatory Response (HVR) at high altitude was hypothesized to cause pharmacokinetics changes, especially metabolism of drugs due to the up regulation of CYP3A4 isoenzyme. These pharmacokinetic alteration could affect pharmacotherapy, probably lead to either sub therapeutic or supra therapeutic effects. This hypothesis was studied with a pop-PK study conducted in healthy male volunte...

A. Thomas *, S. P. Jose, K. M. Poornajith, K. P. Arun, V. Sivakumar and M. K. Samanta

Department of Pharmaceutical Biotechnology, J.S.S. College of Pharmacy, Ooty, J.S.S. University, Mysore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).687-92

687-692

861

262

33.

MORPHOLOGICAL STUDY OF MIDDLE CRANIAL FOSSA AND ITS VARIATIONS

Purpose: To study the morphological details and analyse the morphometry of the various foramens in the dry human skulls of mainly Indian population. Materials and Methods: 64 dry skulls of unknown sex and of Indian origin were used in this study which was carried out at the Department of Anatomy and forensic department of Saveetha Medical College and Hospital in the year 2016. The parameters used ...

P. K. Sankaran*, G. Raghunath, R. Arathala, Karthikeyan, Menaka, Madhumitha, M. Yuvaraj and M. Kumaresan

Department of Anatomy, Saveetha Medical College, Thandalam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).693-01

693-701

799

323

34.

FORMULATION, EVALUATION AND IN VITRO ANTIBACTERIAL SCREENING OF HERBAL GEL CONTAINING MANILKARA HEXANDRA (ROXB.) DUBARD LEAF EXTRACT

Manilkara hexandra (Roxb.) [Synonym: Mimusops hexandra] belonging to family Sapotaceae is revealed to be endowed with antibacterial activity. Leaves, fruits, roots and barks of the plant are renowned for their medicinal values. Herbal gels have prevalence over conventional gels in piling up the therapeutic efficiency and narrowing down the side effects. The design of present study is to formulate ...

D. Pingili *, D. Amminbavi, A. Awasthi and F. M. S. Khan

Department of Pharmaceutical Chemistry, Sri Venkateshwara College of Pharmacy and Research Centre, Madhapur, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).702-07

702-707

950

345

35.

PAEDIATRICIANS COGNIZANCE ABOUT THE DELETERIOUS EFFECT OF ANTIBIOTICS AND DENTAL CARIES – A PRELIMINARY STUDY

Aim: To evaluate pediatricians’ cognizance about the use of antibiotics and dental caries. Materials and Method: 200 Pediatricians’ who were willing to participate were selected randomly from public and private medical hospitals in South India. A pretested questionnaire was distributed to the Paediatricians’ and was personally contacted to receive the responses within a week’s time. Descri...

V. Anu*, S. Harshamol, T. Helena, P. D. Hannah, R. Gokila and H. Manomani

Department of Public Health Dentistry, Sathyabama University Dental College and Hospital, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).708-11

708-711

692

258

36.

ANTIBACTERIAL AND ANTIMYCOBACTERIAL ACTIVITY OF MEDICINAL ORCHID OF ARUNACHAL PRADESH

Orchidaceae, one of the largest families of plant kingdom, possesses high aesthetic, medicinal and economic value. However, medicinal properties of orchids has not been investigated to its fullest potential. Hence, an orchid of Arunachal Pradesh, Pleione maculata, which has not been studied from pharmacological and phytochemical view point so far, is selected for the study. The present study was c...

M. Bhatnagar and S. Ghosal*

Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).712-17

712-717

962

318

37.

ANTHELMINTIC ACTIVITY OF WHOLE PLANT EXTRACT OF AERVA LANATA LINN. JUSS IN NATURALLY INFECTED SHEEP

The anthelmintic activity of ethanolic extract of whole plant of Aerva lanata was studied in sheep with natural acute/sub-acute parasitic gastro-enteritis due primarily to mixed nematode species. Graded doses of the extract (100,200 and 300 mg/kg, p.o for five consecutive days) significantly reduced faecal egg counts in infected animals. The percentage reduction (96.1%) by 300 mg/kg of the extract...

A. Jaswanth*, S. Suddagoni, S. K. Chiliveri, G. Akula and S. S. Phanindra

Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda, Gajwel, Siddipet, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).718-21

718-721

840

260

38.

KNOWLEDGE, ATTITUDE AND PRACTICE RELATED TO CERVICAL CANCER AND SCREENING AMONG WOMEN: COMMUNITY BASED CROSS – SECTIONAL STUDY

Introduction: To assess the level of knowledge, attitude, and practices of women of reproductive age of 20 - 70 years on their understanding of the risk factors of cervical cancer, its early detection, and prevention. Methods: A cross-sectional study was conducted in rural areas of Komarapalayam from August 2016 to January 2017 by using pre-tested modified questionnaire. The purpose of the questio...

K. Krishnaveni*, P. Roy and R. Sambathkumar

Department of Pharmacy Practice, J. K. K. Nattraja College of Pharmacy, Komarapalayam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).722-29

722-729

1729

426

39.

EVALUATION OF PREVALENCE, KAP AND PRESCRIBING PATTERN OF DRUGS TO TYPE 2 DIABETIC PATIENTS AND ASSESSMENT OF RISK FACTORS AMONG THE NON-DIABETIC PATIENTS IN A TERTIARY CARE HOSPITAL IN SOUTHERN KERALA

A prospective, observational study was conducted among the 100 diabetic and 100 non-diabetic patients for a period of six months for the evaluation of prevalence, KAP (Knowledge, Attitude and Practice) and prescribing pattern of drugs to type 2 diabetic patients and to assess the risk factors of prevalence of diabetes among the non-diabetic patients. All information relevant to the study was colle...

J. Mundiyankal, V. M. Baby and C. D. S. Selvin*

Sreekrishna College of Pharmacy and Research Centre, Parassala, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).730-37

730-737

788

338

40.

ENHANCED ANTIMICROBIAL ACTIVITY OF PROBIOTICS THROUGH SELENIUM NANOPARTICLES ENRICHMENT AGAINST GASTROINTESTINAL PATHOGENS

The decrease in susceptibility towards commonly administered antibacterial agents is due to excessive use of antibiotics every now and then, due to which the resistance toward these antibiotics is developed in pathogens. To overcome the problem of resistance in pathogenic microbes, the study of incorporation of Selenium metal to probioticts supplement was carried out. Antimicrobial activity of ind...

D. K. Zamare* and B. Mishra

Department of Biotechnology, Sreenidhi Institute of Science and Technology (Autonomous), Yamnampet, Ghatkesar, Hyderabad, Telangana State, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).738-42

738-742

845

253

41.

HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT FROM INFLORESCENCE AND POLLEN GRAINS OF CASUARINA EQUISETIFOLIA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN WISTR RATS

India is the largest producer of the medicinal plants and is rightly called the “Botanical Garden of the world”. The objective of the present study is to evaluate the hepatoprotective activity of aqueous extract of Inflorescence (IA) and Pollen grains (PA) of Casuarina equisetifolia belongs to the family of Casuarinaceae against Paracetamol induced hepatotoxicity in Wistar rats. The aqueous ex...

O. U. Rao*, M. C. Eswaraiah, M. C. Prabhakar and D. Santhikrupa

Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).743-47

743-747

754

279

42.

A COMPARATIVE STUDY TO EVALUATE EFFICACY, SAFETY AND COST EFFECTIVENESS BETWEEN ORAL BALOFLOXACIN VS. ORAL LEVOFLOXACIN IN PATIENTS OF ACUTE, UNCOMPLICATED URINARY TRACT INFECTION ATTENDING C. U. SHAH MEDICAL COLLEGE, SURENDRANAGAR

Objectives: To compare the efficacy, safety and cost effectiveness between oral Balofloxacin and oral Levofloxacin in acute uncomplicated urinary tract infections. Methods: Total 130 patients were enrolled for the study, out of them 119 patients completed the study. Patients were divided into two groups randomly; 63 patients received Balofloxacin 100 mg BID orally and 56 patients received Levoflox...

T. Acharya, M. Trivedi*, B. Tilva, S. Chhaiya and D. Mehta

Department of Pharmacology, C. U. Shah Medical College and Hospital, Surendranagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).748-54

748-754

866

310

43.

FACTORS AFFECTING ADHERENCE TO ANTIHYPERTENSIVE MEDICATION REGIMEN AMONG HEMODIALYSIS PATIENTS ATTENDING A PRIVATE HOSPITAL IN MOMBASA, KENYA

Introduction: Patients with chronic kidney disease undergoing hemodialysis are usually co-morbid with hypertension that contributes to increased cardiovascular morbidity and mortality if not controlled. A number of factors are targeted as influencing agents to uncontrolled hypertension but adherence to treatment is counted as a major factor contributing to poor control of hypertension. Methods: A ...

S. Otenyo* and A. Maranga

Department of Nursing, Faculty of Health Sciences, Egerton University, Njoro, Kenya.

DOI: 10.13040/IJPSR.0975-8232.9(2).755-60

755-760

1070

292

44.

EFFECTS OF BETA-ADRENOCEPTOR BLOCKERS ON THE PLATELET AND CARDIOMETABOLIC INDICES IN UNCONTROLLED HYPERTENSION

Background: Metabolic derangement in term of glucose dysregulation, dyslipidemia, and electrolyte disturbances are the adverse reactions of beta-adrenoceptor blockers that limit their use. Aims: To investigate the effect of BARBs on the cardio-metabolic risk factors and platelet indices that play a role in accelerating the atherogenicity. Materials and methods: This observational clinical study wa...

Z. A. G. Mohammed Ali

Department of Clinical Pharmacy, College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq.

DOI: 10.13040/IJPSR.0975-8232.9(2).761-65

761-765

631

275

45.

INVESTIGATING THE LINK BETWEEN TRANSFORMATIONAL LEADERSHIP, PSYCHOLOGICAL EMPOWERMENT, AFFECTIVE COMMITMENT AND ORGANIZATIONAL CITIZENSHIP BEHAVIOR IN THE PHARMACEUTICAL SECTOR OF INDONESIA

Modern organizations face increasing competition due to globalization, technological change, politics and economics. In order to cope with these, public organizations, including organizations at the central and local government levels, must improve their efficiency and performance to reflect the presence of organization in other countries. Leaders, therefore, must act more quickly in encouraging a...

S. Handayani, Udin*, A. Yuniawan, T. Wikaningrum and S. Supriyati

Diponegoro University, Jl. Erlangga, Semarang, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.9(2).766-74

766-774

801

378

46.

ASSESSMENT OF HEAVY METALS CONTENT OF SOME PLANT BASED MEDICINES IN PARTS OF SOUTHERN NIGERIA, WEST AFRICA

The concentration levels and human health risk of iron, cadmium, zinc, nickel, copper and lead were determined in 25 popularly consumed types of commercially available herbal drugs in Southern Nigeria. In each type, three brands were selected and analysed. The study area was divided into five sampling zones (A - E) and the herbal drugs were categorized into five clusters based on their advertised ...

R. N. Ekere*, N. J. Ihedioha, I. J. Ayogu, I. F. Ogbefi-Chima, U. S. Onoja and L. O. Alum

Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.9(2).775-83

775-783

745

294

47.

EFFECT OF FRESH JUICE OF KHAT (CATHA EDULIS) ON BLOOD GLUCOSE LEVELS OF NORMOGLYCEMIC AND STREPTOZOCIN-INDUCED DIABETIC RATS

Khat is chewed traditionally in Ethiopia, Somalia, Yemen and Kenya. In Ethiopia, khat chewing is now becoming an everyday substance of abuse for the general population. Knowledge about the effects of khat chewing on blood glucose levels is very sparse. Therefore, the objective of this study was to investigate the effect of fresh juice of khat (Catha edulis) on blood glucose levels of normal and st...

D. A. Debecho*, Y. A. Kinfe, T. T. Dugul and D. S. Melka

Department of Physiology, St. Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia.

DOI: 10.13040/IJPSR.0975-8232.9(2).784-89

784-789

911

304

48.

DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF ILOPERIDONE IN RAT PLASMA

A simple and fast isocratic reverse phase- high performance liquid chromatography (RP-HPLC) method was developed for estimation of iloperidone from rat plasma employing a photo diode array (PDA) detector. The plasma samples were prepared by protein precipitation using acetonitrile as extracting solvent. The chromatographic separation was performed on a BDS Hypersil Phenyl column (250 mm × 4.6 ...

V. Dubey and T. R. Saini*

Industrial Pharmacy Research Lab, Department of Pharmacy, Shri G. S. Institute of Technology and Science, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).790-94

790-794

734

274

49.

DNA BARCODING AND BIOLOGICAL ASSESSMENT ON A FEW MANGROVE PLANT SPECIES OF VISAKHAPATNAM COAST, ANDHRA PRADESH, INDIA

DNA barcoding is currently gaining popularity due to its simplicity and high accuracy as compared to the complexity and subjective biases associated with morphology-based identification of taxa. The standard chloroplast DNA barcode for land plants is normally recommended by the Consortium for the Barcode of Life (CBOL) plant working group that needs to be evaluated for a wide range of plant specie...

P. Suman *, T. S. D. Raj, P. R. Vani and S. H. Sreeramulu

Department of Biotechnology, Center for Research, Dr. V. S. Krishna Government Autonomous College, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).795-18

795-818

938

288

50.

IMPACT OF CLINICAL PHARMACIST IN THE MONITORING OF DRUG – RELATED PROBLEMS IN PSYCHIATRY PATIENTS AT TERTIARY CARE TEACHING HOSPITAL

Background: Advancement in pharmacotherapy leading the new drug discovery for the clinical problem, as well as it’s also exploring the clinical applications and Drug-Related Problem (DRP). DRP is an event or circumstances, which involving drug treatment that interfere or potentially interferes with patient achieving an optimum outcome of medical care. DRP cause significant morbidity and mortalit...

S. C. Wali, M. S. Ganachari, A. S. Parihar * and S. B. Sonawale

Department of Pharmacy Practice, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).819-23

819-823

712

262

51.

FORMULATION DEVELOPMENT OF MICROSPONGE BASED DELAYED RELEASE DOSAGE FORM OF LANSOPRAZOLE

The aim of study is to develop microsponge based delayed release dosage form, technique used to manufacture microsponge was quasi emulsion diffusion technique. Eudragit L 100 and Eudragit S 100 polymer is used to incorporate lansoprazole in microsponge. Lansoprazole is acid labile drug hence release of lansoprazole was delayed from acid environment. Microsponge contains porous polymeric microspher...

I. Tadwee * and S. Shahi

Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).824-31

824-831

741

312

52.

ANTI-INFLAMMATORY AND IMMUNOMODULATORY ACTIVITY OF ETHANOL EXTRACT OF ALOE VERA GEL

The current treatment of inflammation includes NSAIDs, selective COX-2 inhibitors, glucocorticoids and anti-TNFα has peptic ulcer, renal and hematological toxic side effects as well as some of these drugs are more expensive. Hence it is necessary to evaluate the new cost effective as well as less toxic drug. Aloe vera showing a lots of promise and hence researcher all over are trying to harness t...

R. R. Bhalsinge, S. R. Rajbhoj *, M. V. Limaye, M. U. Vaidya, P. S. Rane and A. V. Tilak

Department of Pharmacology, Dr. D.Y. Patil Medical College, Sant Tukaram Nagar, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).832-35

832-835

837

274