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DETERMINATION OF TOLTERODINE TARTRATE IN PHARMACEUTICAL PREPARATIONS USING EOSIN, APPLICATION TO STABILITY STUDY
Spectrophotometric method has been developed for the determination of Tolterodine tartrate (TOL) which is based on formation of a binary complex between TOL and eosin at 545 nm using acetate buffer at pH 3.8.The absorbance-concentration plot is rectilinear over the range (1-10μg/ml) with LOD of 0.1μg/ml and LOQ of 0.31μg/ml. The proposed method was successfully applied to the analysis of commer...
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ROLE OF THE INCRETINS IN HYPOGLYCEMIC EFFECT OF PHLOGACANTHUS THYRSIFLORUS NEES IN CHEMICALLY INDUCED DIABETIC MICE
Objective: This study was aimed to evaluate the role of GLP-1, GIP in the hypoglycemic activity of Phlogacanthus thyrsiflorus Nees. Materials and Methods: We have evaluated the influence of Phlogacanthus thyrsiflorus Nees, a traditionally used antidiabetic medicinal plant on some metabolic parameters, glucose homeostasis, insulin production, glucagon like peptide 1 (GLP1) and gastric Inhibitory Po...
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ISOLATION AND ANTIMICROBIAL AND DEGRADATIVE POTENTIAL OF ACTINOMYCETES
Problem Statement: Do the soil Actinomycetes do have Antimicrobial and Petrol degradation potential? An intriguing question. Actinomycetes are continues to be a subject of study with reference to their Antimicrobial and degradative potential. However studies have been done is limited. Our object was to study its Antimicrobial activity in wide spectrum and to study its degradation potential on Petr...
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SCREENING OF ANTIMICROBIAL PROPERTIES OF PHENOL SCHIFF BASES
In their fight for supremacy and survival, microorganisms have been developing and devising various methods to inactivate the action of antibiotics. The numbers of drug resistant microorganisms with reduced susceptibility to various antibiotics are increasing. Therefore, new infection-fighting strategies are required to control microbial infections. The interaction between potent chemicals and liv...
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DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR DETERMINATION OF CERITINIB IN RABBIT PLASMA USING PDA DETECTOR
A rapid, sensitive and reproducible HPLC method was developed and validated for the quantification of Ceritinib in rabbit plasma using PDA detector at wave length 264 nm. The method was developed using Dasatinib as internal standard (IS). Ceritinib is a selective and potent inhibitor of anaplastic lymphoma kinase (ALK) indicated in the treatment of non-small cell lung cancer (NSCLC). The Ceritinib...
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DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD OF APIXABAN IN COMMERCIAL DOSAGE FORM
The aim of this study is to develop a sensitive, specific, rapid, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method and validate it for the quantification of process-related and degradation impurities of apixaban; an anticoagulant drug. The chromatographic separation was achieved on a Sigma-Aldrich’s Ascentis Express® C18 (4.6 mm × 100 mm, 2.7 µ) HPLC column wi...
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COMPUTATIONAL UNDERSTANDING OF SELECTIVE MMP INHIBITORS IN COPD
Chronic Obstructive Pulmonary Diseases (COPD) refers to multiple lung diseases, is the occurrence of chronic bronchitis and emphysema, a pair of commonly co-existing diseases of the lungs in which the airways become narrowed because of inflammatory cells like neutrophils, CD8 cells and macrophages. These cells produce the Matrix metalloproteinases (MMPs), cathapsins and other proteinase enzymes. I...
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SYNTHESIS, CHARACTERIZATION AND ANALGESIC ACTIVITY OF SEVERAL NEW N-SUBSTITUTED PHTHALIMIDE ANALOGUES
The synthesis, characterization and spectroscopic studies of new N-substituted pthalimide analogues 2–7 with analgesic activity were described. The compounds were synthesized using phthalic anhydride with various appropriate amines (Triazolamine, Benzocaine, p-Nitro-aniline, pyrazinamide, Phenazone and glycine) in reflux synthesizer. The purity of the compounds was determined by TLC. With the ph...
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EVALUATION OF NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF BAUHINIA PURPUREA IN GENTAMICIN INDUCED NEPHROTOXICITY IN RATS
Objective: To study the nephroprotective activity of Bauhinia purpurea unripe pods and bark against gentamicin-induced nephrotoxicity. Materials and Methods: Twenty four healthy adult albino rats of either sex (150-200 g) were randomly divided into four groups of six animals each. Group, I served as vehicle control and Group II as the negative control (gentamicin 80 mg/kg/d, i.p). Groups III and I...
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HOMOLOGY MODELING AND DOCKING STUDIES ON HIV REVERSE TRANSRIPTASE INHIBITORS
The usefulness of computational methods in drug design process is no longer a point of debate. The contributions from this evolving field have become apparent to both pharmaceutical scientists and academic biomedical researchers. As all the computational drug design are based on statistical and mathematical calculations there is strong evidences present for each and every step, thus research by ch...
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