Volume 9 (2018) - Issue 2, February
NEW ADVANCEMENTS OF BIOPLASTICS IN MEDICAL APPLICATIONS
The bio-plastics that are produced either from fossil material or can be synthesized from biomass or renewable resources, such as Poly-lactic acid (PLA), Polyethylene glycol (PEG) and Poly - ε - caprolactone (PCL) are been reported as a material of choice for biomedical applications due to their good physical properties such as crystallinity, storage modulus, glass transition temperature and bior...
AN OVERVIEW OF DANDRUFF AND NOVEL FORMULATIONS AS A TREATMENT STRATEGY
This review gives an insight of the scalp condition- dandruff which affects more than 50% of the human population. Malassezia furfur is reported as the main cause of dandruff. This article aims at investigating other causes of dandruff which include microbial and non - microbial factors. These factors have been explained in this article. It also highlights the various treatment options and newer f...
MEDICINAL USE OF AN ANCIENT HERB MOMORDICA CYMBALARIA: A REVIEW
Momordica cymbalaria (Hook, Fenzl) is a vine of Momordica genus found in the Indian states of Karnataka, Madhya Pradesh, Maharashtra, Andhra Pradesh and Tamil Nadu. The medicinal herb also been named Luffa tuberose (Roxb) or Momordica tuberose (Roxb). Momordica cymbalaria is commonly known as Karchikai (Kannada) or Athalakkai (Tamil) or Kasarakayee (Andhra Pradesh) and Kakrol (India). Momordica cy...
MITOCHONDRIA – TARGETED ANTIOXIDANT: AGING
The mitochondrion, the “power house of cell”, plays a central role in energy-generating processes so called as ‘‘master of life and death’’. A decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders. With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to accumulation of mutations and ...
AN UPDATED PHARMACOLOGICAL ACTIVITY OF COCCINIA INDICA (WIGHT & ARN.)
Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules. Coccinia indica belongs to the family Cucurbitaceae. It is a rapidly growing, perennial climber or trailing vine. Traditionally different parts of this plant namely the roots, leaves and fruits are used in folklor...
DESIGN AND EVALUATION OF CHITOSAN-BASED MICROPARTICLES AS MODELS OF PROTEIN DELIVERY SYSTEMS
Controlled release systems for protein and peptide vaccines based polymers have been considered for many applications in medical therapies. Chitosan is non-toxic and easily absorbed biopolymers and is often used in many researches to sustained release drugs and proteic vaccines. This study investigates the kinetics of release in vitro of bovine serum albumin (BSA) from chitosan microparticles and ...
T-CELL ACTIVATION CONTROLLING EFFECTS OF ETHYL ACETATE FRACTION OF KALANCHOE PINNATA (LMK) PERS ON TMPD-TREATED LUPUS MICE
T-cell activation, with the low expression of CD62L (L-selectin) marker in the spleen, will increase B cell activity to produce lupus antibodies. Therefore, lupus patients need drugs which could increase the L- selectin expression in the spleen to reduce the auto-reactive T cell. The tested drug to increase the L-selectin in this research was the ethyl acetate fraction of Kalanchoe pinnata (Lmk) P...
EVALUATION OF HISTO-PATHOLOGICAL CHANGES IN THE MICE EXPOSED TO SODIUM NITRITE FOR LONG TERM BY USING HEMATOXYLIN AND EOSIN STAINING
Objective: The aim of this study is to investigate whether exposure to subclinical dose of sodium nitrite for long term can trigger histopathological changes which are able to detect by using hematoxylin and eosin stain. Sodium nitrite has various properties that make it widely used in industrial and pharmaceutical fields. Method: Three groups of mice were used in this study; the first group was...
STUDIES ON PHYTOCHEMICAL SCREENING – GC-MS CHARACTERIZATION, ANTIMICROBIAL AND ANTIOXIDANT ASSAY OF BLACK CUMIN SEEDS (NIGELLA SATIVA) AND SENNA ALEXANDRIA (CASSIA ANGUSTIFOLIA) SOLVENT EXTRACTS
As science encourage most of the medicinal plants as supreme source of unlimited chemical compounds which are of great interest in pharmacological preparations. The present investigation was aimed to study Nigella sativa seeds and Cassia angustifolia leaf solvent extract (petroleum ether, methanol and aqueous solutions) for phytochemical screening, GC-MS characterization, Antimicrobial and Antioxi...
SYNTHESIS OF BENZO[G]QUINOXALINE-5,10-DIONE BASED PYRAZOLINE DERIVATIVES AND THEIR ANTIMYCOBACTERIAL ACTIVITY
Eleven new compounds belonging to series 7-[5-(substituted) phenyl - 4, 5-dihydro-1H-pyrazol-3-yl]-2,3-diphenyl-5H, 10H - benzo[g] quinoxaline - 5, 10 - dione (Compound 7a-k) were synthesized by multistep synthetic scheme. The newly synthesized compounds were screened for their in-vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv by L.J. Slope (Conventional) Method. Compo...
DNA- BINDING AND CLEAVAGE STUDIES OF Mn(II) AND Co(II) COMPLEXES OF 1-(2,5-DIOXOPYRROLIDIN-1-YL)(4-HYDROXY PHENYL)METHYL) THIOUREA)
A novel Mannich base ligand 1-(2,5-dioxopyrrolidin-1-yl) (4-hydroxy phenyl)methyl)thiourea (PSTU) and its Manganese (II) and Cobalt (II) complexes have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, FT-IR, 1H NMR and 13C NMR spectroscopic studies. The antimicrobial activities and antioxidant activities of the free lig...
STUDIES ON ANTI-INFLAMMATORY EFFECT OF MESUA FERREA LINN. IN ACUTE AND CHRONIC INFLAMMATION OF EXPERIMENTAL ANIMALS
Mesua ferrea Linn. (M. ferrea) is an endemic medicinal plant used for the treatment of inflammation, rheumatism, bronchitis, fever, headache, asthma and skin diseases. The aim of this study was to investigate the anti-inﬂammatory activities of 80% ethanol extract from stem bark of Mesua ferrea Linn. using animal models. Female Wistar albino rats weighing (150-200g) were used for the study. Anti-...
ANTIOXIDANT AND LIPID LOWERING EFFECTS OF ELAEOCARPUS GANITRUS IN CHOLESTEROL FED RABBITS
Elaeocarpus ganitrus Roxb. is reported to exhibit multifarious pharmacological activities. However no scientific study has been conducted to evaluate antiatherosclerotic /lipid lowering activity of E. ganitrus Roxb. The present study was designed to investigate the antihyperlipidaemic and antioxidant activity of 70% ethanolic extract of E. ganitrus seed (EGEE) in cholesterol fed hyperlipidaemic ra...
GC-MS ANALYSIS OF CALLUS AND LEAF EXTRACTS OF IN VITRO PROPAGATED PLANTS OF JUSTICIA WYNAADENSIS (NEES) T. ANDERSON
The present study was aimed at induction of callus, micropropagation of Justicia wynaadensis (Nees) T. Anderson in vitro by using different explants and study of the phytocomponents present in the aqueous and methanol extracts of callus and leaf of in vitro propagated plants through GC-MS analysis. Callus was induced using MS basal medium supplemented with combinations of 2, 4-D, IAA and NAA growt...
BISPHENOL A ENHANCES GROWTH OF Hep-G2 CANCER CELLS BY UPREGULATING EXPRESSION OF PRO – INFLAMMATORY AND PRO – ANGIOGENESIS PROTEINS
Bisphenol A (BPA) is primarily used in the manufacture of plastics and resins. There are many scientific reports that point to the adverse effects of this chemical to different animal models. There has been an increase in use of plastic during the last couple of decades and this has increased human exposure to plasticizers like Bisphenol A. But since little is known on how these endocrine disrupto...
THERAPEUTIC POTENTIAL OF CUCURBITS AGAINST RADIATION INDUCED INFLAMMATION AND DAMAGE IN MICE GUT
Whole body or local irradiation to gut is known to induce significant damage to gut epithelium and crypt stem cells. A large population of microbes in the gut remains unaffected. We hypothesize that the modifications in diet and enteric microbial population may provide a non-toxic mechanism to counter radiation induced health deficit, especially in the gut and therefore investigated the effect of ...
DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL ANTI-TUBERCULAR AGENTS TARGETING GLUTAMINE SYNTHETASE-1 AND CYCLOPROPANEMYCOLIC ACID SYNTHASE-2
The World Health Organization 2015 (WHO) reports indicate that there were 9.0 million new tuberculosis (TB) cases and 1.5 million tuberculosis (TB) deaths during 2015. Co-infection with the HIV fuels the global TB crisis, and successful TB treatment is further complicated and hampered by the existence of multidrug- resistant (MDR) TB and extensively drug resistant (XDR) TB. Hence there is an urgen...
EVALUATION OF IN VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF CASSIA AURICULATA LINN. EXTRACTS
Objective: To evaluate in vitro antioxidant and anti-inflammatory activity of Cassia auriculata leaf extracts. Methods: Herbal extraction was done by Soxhlet extraction method with increasing polarity of Solvents viz., Chloroform, Ethanol, Methanol. Phytochemicals analysis was done using different biochemical tests. Antioxidant potential of plant extracts were analyzed by ferric ion reducing antio...
STUDIES ON AN ANTI-AGING FORMULATION PREPARED USING ALOE VERA BLENDED COLLAGEN AND CHITOSAN
Photochemoprotection has nowadays become inevitable to combat aging. Exposure to Ultraviolet radiations accelerates skin aging which eventually culminates in wrinkles, laxity, dyspigmentation, roughness and dryness. Though many active synthetic topicals have been used since years, the present era of treating an aged skin has been diverted towards natural biomaterials as these synthetic topicals po...
EFFECT OF TRANS – ESTERIFICATION OF OIL ON NANOEMULSION GEL FOR TOPICAL DRUG DELIVERY
The research investigated the modification of nano-emulsion by using transesterfied soyabean oil, to enhanced solubility and diffusion of voriconazole. Ternary phase diagrams of soyabean oil, acid / base esters of soyabean oil, Tween 80: PEG 400 (S/CoS) and water were developed. Ester value of soyabean oil increased from 214.04 to 261.5mg KOH/1g for acid ester and 293.58mg KOH/1g for base ester co...
STABILITY INDICATING RP-HPLC METHOD FOR COMBINATION OF PSEUDOEPHEDRINE SULPHATE AND LORATADINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION
Reverse Phase - High performance liquid chromatographic (RP - HPLC) method was described for determination of Pseudoephedrine Sulphate (PSE) and Loratadine Hydrochloride (LOR). The chromatographic separation was achieved using mobile phase mixture of Acetonitrile: 0.05 M Potassium Dihydrogen Phosphate Buffer: (pH 2.8 adjusted with Ortho Phosphoric Acid Solution): Methanol in the ratio of 30:35:35 ...
ANTIOXIDANT ANALYSIS AND ENZYME INHIBITION ASSAY OF PLANTS OF APOCYNACEAE FAMILY FOR ULCERS
Different plants of the Apocynaceae family viz. Alstonia scholaris, Calotropis procera, Rauvolfia serpentine, Hemidesmus indicus and Calotropis gigantean are traditionally being reported in ulcers treatments. The present study was aimed to validate the authenticity of correlationship of various phytoconstituents concentrations, antioxidant activity and urease inhibitory potential of the same. Vari...
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF BENZIMIDAZOLE DERIVATIVES
Benzimidazoles are an important class of compounds with a wide spectrum of biological activity ranging from anti-hypertensive, anti-viral, anti-fungal, antitumor and anthelmintic activity. Benzimidazole rings are the most important nitrogen-containing heterocycles, which are widely explored and utilized by the pharmaceutical industry for drug discovery. Due to their special structural features and...
ALKALINE DEGRADATION KINETICS AND STABILITY INDICATING RP-HPLC METHOD FOR THE ESTIMATION OF FLAVOXATE HYDROCLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS
A simple stability indicating reversed-phase HPLC method was developed, validated and subsequently alkaline degradation kinetics are also determined for the estimation of Flavoxate Hydrocloride (FVH) present in pharmaceutical dosage forms. The proposed RP-HPLC method utilizes a LiChroCART - Lichrosphere 100, C18 RP column Hibar® (250 × 4 mm, 5 μm) in an isocratic separation mode with mobile pha...
DEVELOPMENT AND IN VITRO EVALUATION OF SELF EMULSIFYING FORMULATION FOR EMBELIN
The purpose of present work was to improve the oral bioavailability of embelin by formulating this hydrophobic phytoconstituent as self emulsifying drug delivery system (SEDDS). SEDDS improves the oral bioavailability by overcoming the dissolution step, enzymatic degradation and hepatic first pass metabolism of phytoconstituent. On the basis of solubility study of embelin, ethyl oleate, tween 80 a...
1-[3/-(SUBSTITUTED PHENYL) -5/- (AMINO PYRIMIDINE)]- 3- (4/-NITRO PHENYL) 5-(SUBSTITUTED PHENYL)- 2-PYRAZOLINES: SYNTHESIS, CHRACTERISATION AND ANTIMICROBIAL SCREENING
In the present study eight novel 2-pyrazoline - amino pyrimidine hybrids have been synthesized in order to search new chemical entities with increased pharmacological properties. The targeted analogues were synthesized in four steps; Claisen-schmidt condensation of 4-nitro acetophenone with different benzaldehydes in basic medium to yield precursor chalcone which was cyclised using hydrazine hydra...
AN EFFICIENT, GREENER MICROWAVE ASSISTED MULTI-COMPONENT ONE POT SYNTHESIS OF [1, 3, 4] THIADIAZIN-2-YL-THIAZOLIDIN-4-ONES
This work involves synthesis of [1, 3, 4] thiadiazin-2-ylamine 3(a-c) derivatives from various substituted acetophenone derivatives 1(a-c), and thiosemicarbazide 2 mixed in ethanol and irradiation with microwaves which were directly used for next step. [1, 3, 4]Thiadiazin-2-yl)-thiazolidin-4-one 6(a-f) were synthesized in the second step from substituted-6H-[1, 3, 4] thiadiazin-2-ylamine 3(a-c), s...
FORMULATION AND EVALUATION OF DILTIAZEM HCl FAST DISSOLVING TABLETS USING DIFFERENT CO-PROCESSED EXCIPIENTS BY DIRECT COMPRESSION METHOD
The aim of present work was to prepare Diltiazem HCl Fast Dissolving tablets by Direct compression method because of their convenience in administration and suitability for patients having dysphagia using Co-processed excipients - Disintequik MCC25, Disintequik MCC, Lubritose MCC, Lubritose SD, Lubritose AN, NF Fast flo Lactose Monohydrate modified spray dried. The Prepared powdered blend and tabl...
NEUROPROTECTIVE PROPERITY OF CENTELLA ASIATICA AGAINST PENTYLENE- TETRAZOLE INDUCED EPILEPSY IN RAT BRAIN WITH PARTICULAR REFERENCE TO LIPID METABOLISM
This study evaluated the anticonvulsant effect of different extracts of Centella asiatica (CA) with particular reference to lipid metabolism in different regions of rat brain. The rats were randomly divided into 4 groups having 6 in each group: i.e. Control group received saline, PTZ-induced epileptic group (60mg/kg b.w op/ 1 day), epileptic group pretreated with chloroform extract (CE),...
EFFECT OF HIGH ENERGY BALL MILLING GRINDING ON PHYSICO-CHEMICAL, MORPHOLOGICAL AND OPTICAL PROPERTIES OF CURCUMA LONGA NANOPARTICLES POWDERS
Curcuma longa nano powder was prepared by high energy ball milling equipment using green synthesis. Green synthesis is the process of synthesizing nanoparticle from biogenic resources based on the fact of its bioactive potential would be less toxic (product & bi-product), environmental safety (eco-friendly and biodegradable) cost effective and easily available to its natural origin. The powder...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING UV SPECTRO-PHOTOMETRIC METHOD FOR THE ESTIMATION OF BENZYDAMINE HYDROCHLORIDE IN BULK AND IN PHARMACEUTICAL DOSAGE FORM: A NOVEL ANALYTICAL TECHNIQUE FOR CONDUCTING IN-VITRO QUALITY CONTROL TESTS
The objective of the present study is to develop and validate a novel stability indicating UV spectrophotometric method for estimation of Benzydamine Hydrochloride (BNZ) in pharmaceutical dosage form as not a single UV spectrophotometric method has been reported for the estimation of Benzydamine Hydrochloride, which makes the present work novel. In the present research work, UV spectrophotometric ...
THE HYPOXIC VENTILLATORY RESPONSE AND HEPATIC CYP3A4 UPREGULATION IN HUMAN AT HIGH ALTITUDE
The Hypoxic Ventillatory Response (HVR) at high altitude was hypothesized to cause pharmacokinetics changes, especially metabolism of drugs due to the up regulation of CYP3A4 isoenzyme. These pharmacokinetic alteration could affect pharmacotherapy, probably lead to either sub therapeutic or supra therapeutic effects. This hypothesis was studied with a pop-PK study conducted in healthy male volunte...
MORPHOLOGICAL STUDY OF MIDDLE CRANIAL FOSSA AND ITS VARIATIONS
Purpose: To study the morphological details and analyse the morphometry of the various foramens in the dry human skulls of mainly Indian population. Materials and Methods: 64 dry skulls of unknown sex and of Indian origin were used in this study which was carried out at the Department of Anatomy and forensic department of Saveetha Medical College and Hospital in the year 2016. The parameters used ...
FORMULATION, EVALUATION AND IN VITRO ANTIBACTERIAL SCREENING OF HERBAL GEL CONTAINING MANILKARA HEXANDRA (ROXB.) DUBARD LEAF EXTRACT
Manilkara hexandra (Roxb.) [Synonym: Mimusops hexandra] belonging to family Sapotaceae is revealed to be endowed with antibacterial activity. Leaves, fruits, roots and barks of the plant are renowned for their medicinal values. Herbal gels have prevalence over conventional gels in piling up the therapeutic efficiency and narrowing down the side effects. The design of present study is to formulate ...
PAEDIATRICIANS COGNIZANCE ABOUT THE DELETERIOUS EFFECT OF ANTIBIOTICS AND DENTAL CARIES – A PRELIMINARY STUDY
Aim: To evaluate pediatricians’ cognizance about the use of antibiotics and dental caries. Materials and Method: 200 Pediatricians’ who were willing to participate were selected randomly from public and private medical hospitals in South India. A pretested questionnaire was distributed to the Paediatricians’ and was personally contacted to receive the responses within a week’s time. Descri...
ANTIBACTERIAL AND ANTIMYCOBACTERIAL ACTIVITY OF MEDICINAL ORCHID OF ARUNACHAL PRADESH
Orchidaceae, one of the largest families of plant kingdom, possesses high aesthetic, medicinal and economic value. However, medicinal properties of orchids has not been investigated to its fullest potential. Hence, an orchid of Arunachal Pradesh, Pleione maculata, which has not been studied from pharmacological and phytochemical view point so far, is selected for the study. The present study was c...
ANTHELMINTIC ACTIVITY OF WHOLE PLANT EXTRACT OF AERVA LANATA LINN. JUSS IN NATURALLY INFECTED SHEEP
The anthelmintic activity of ethanolic extract of whole plant of Aerva lanata was studied in sheep with natural acute/sub-acute parasitic gastro-enteritis due primarily to mixed nematode species. Graded doses of the extract (100,200 and 300 mg/kg, p.o for five consecutive days) significantly reduced faecal egg counts in infected animals. The percentage reduction (96.1%) by 300 mg/kg of the extract...
KNOWLEDGE, ATTITUDE AND PRACTICE RELATED TO CERVICAL CANCER AND SCREENING AMONG WOMEN: COMMUNITY BASED CROSS – SECTIONAL STUDY
Introduction: To assess the level of knowledge, attitude, and practices of women of reproductive age of 20 - 70 years on their understanding of the risk factors of cervical cancer, its early detection, and prevention. Methods: A cross-sectional study was conducted in rural areas of Komarapalayam from August 2016 to January 2017 by using pre-tested modified questionnaire. The purpose of the questio...
EVALUATION OF PREVALENCE, KAP AND PRESCRIBING PATTERN OF DRUGS TO TYPE 2 DIABETIC PATIENTS AND ASSESSMENT OF RISK FACTORS AMONG THE NON-DIABETIC PATIENTS IN A TERTIARY CARE HOSPITAL IN SOUTHERN KERALA
A prospective, observational study was conducted among the 100 diabetic and 100 non-diabetic patients for a period of six months for the evaluation of prevalence, KAP (Knowledge, Attitude and Practice) and prescribing pattern of drugs to type 2 diabetic patients and to assess the risk factors of prevalence of diabetes among the non-diabetic patients. All information relevant to the study was colle...
ENHANCED ANTIMICROBIAL ACTIVITY OF PROBIOTICS THROUGH SELENIUM NANOPARTICLES ENRICHMENT AGAINST GASTROINTESTINAL PATHOGENS
The decrease in susceptibility towards commonly administered antibacterial agents is due to excessive use of antibiotics every now and then, due to which the resistance toward these antibiotics is developed in pathogens. To overcome the problem of resistance in pathogenic microbes, the study of incorporation of Selenium metal to probioticts supplement was carried out. Antimicrobial activity of ind...
HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT FROM INFLORESCENCE AND POLLEN GRAINS OF CASUARINA EQUISETIFOLIA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN WISTR RATS
India is the largest producer of the medicinal plants and is rightly called the “Botanical Garden of the world”. The objective of the present study is to evaluate the hepatoprotective activity of aqueous extract of Inflorescence (IA) and Pollen grains (PA) of Casuarina equisetifolia belongs to the family of Casuarinaceae against Paracetamol induced hepatotoxicity in Wistar rats. The aqueous ex...
A COMPARATIVE STUDY TO EVALUATE EFFICACY, SAFETY AND COST EFFECTIVENESS BETWEEN ORAL BALOFLOXACIN VS. ORAL LEVOFLOXACIN IN PATIENTS OF ACUTE, UNCOMPLICATED URINARY TRACT INFECTION ATTENDING C. U. SHAH MEDICAL COLLEGE, SURENDRANAGAR
Objectives: To compare the efficacy, safety and cost effectiveness between oral Balofloxacin and oral Levofloxacin in acute uncomplicated urinary tract infections. Methods: Total 130 patients were enrolled for the study, out of them 119 patients completed the study. Patients were divided into two groups randomly; 63 patients received Balofloxacin 100 mg BID orally and 56 patients received Levoflox...
FACTORS AFFECTING ADHERENCE TO ANTIHYPERTENSIVE MEDICATION REGIMEN AMONG HEMODIALYSIS PATIENTS ATTENDING A PRIVATE HOSPITAL IN MOMBASA, KENYA
Introduction: Patients with chronic kidney disease undergoing hemodialysis are usually co-morbid with hypertension that contributes to increased cardiovascular morbidity and mortality if not controlled. A number of factors are targeted as influencing agents to uncontrolled hypertension but adherence to treatment is counted as a major factor contributing to poor control of hypertension. Methods: A ...
EFFECTS OF BETA-ADRENOCEPTOR BLOCKERS ON THE PLATELET AND CARDIOMETABOLIC INDICES IN UNCONTROLLED HYPERTENSION
Background: Metabolic derangement in term of glucose dysregulation, dyslipidemia, and electrolyte disturbances are the adverse reactions of beta-adrenoceptor blockers that limit their use. Aims: To investigate the effect of BARBs on the cardio-metabolic risk factors and platelet indices that play a role in accelerating the atherogenicity. Materials and methods: This observational clinical study wa...
INVESTIGATING THE LINK BETWEEN TRANSFORMATIONAL LEADERSHIP, PSYCHOLOGICAL EMPOWERMENT, AFFECTIVE COMMITMENT AND ORGANIZATIONAL CITIZENSHIP BEHAVIOR IN THE PHARMACEUTICAL SECTOR OF INDONESIA
Modern organizations face increasing competition due to globalization, technological change, politics and economics. In order to cope with these, public organizations, including organizations at the central and local government levels, must improve their efficiency and performance to reflect the presence of organization in other countries. Leaders, therefore, must act more quickly in encouraging a...
ASSESSMENT OF HEAVY METALS CONTENT OF SOME PLANT BASED MEDICINES IN PARTS OF SOUTHERN NIGERIA, WEST AFRICA
The concentration levels and human health risk of iron, cadmium, zinc, nickel, copper and lead were determined in 25 popularly consumed types of commercially available herbal drugs in Southern Nigeria. In each type, three brands were selected and analysed. The study area was divided into five sampling zones (A - E) and the herbal drugs were categorized into five clusters based on their advertised ...
EFFECT OF FRESH JUICE OF KHAT (CATHA EDULIS) ON BLOOD GLUCOSE LEVELS OF NORMOGLYCEMIC AND STREPTOZOCIN-INDUCED DIABETIC RATS
Khat is chewed traditionally in Ethiopia, Somalia, Yemen and Kenya. In Ethiopia, khat chewing is now becoming an everyday substance of abuse for the general population. Knowledge about the effects of khat chewing on blood glucose levels is very sparse. Therefore, the objective of this study was to investigate the effect of fresh juice of khat (Catha edulis) on blood glucose levels of normal and st...
DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF ILOPERIDONE IN RAT PLASMA
A simple and fast isocratic reverse phase- high performance liquid chromatography (RP-HPLC) method was developed for estimation of iloperidone from rat plasma employing a photo diode array (PDA) detector. The plasma samples were prepared by protein precipitation using acetonitrile as extracting solvent. The chromatographic separation was performed on a BDS Hypersil Phenyl column (250 mm × 4.6 ...
DNA BARCODING AND BIOLOGICAL ASSESSMENT ON A FEW MANGROVE PLANT SPECIES OF VISAKHAPATNAM COAST, ANDHRA PRADESH, INDIA
DNA barcoding is currently gaining popularity due to its simplicity and high accuracy as compared to the complexity and subjective biases associated with morphology-based identification of taxa. The standard chloroplast DNA barcode for land plants is normally recommended by the Consortium for the Barcode of Life (CBOL) plant working group that needs to be evaluated for a wide range of plant specie...
IMPACT OF CLINICAL PHARMACIST IN THE MONITORING OF DRUG – RELATED PROBLEMS IN PSYCHIATRY PATIENTS AT TERTIARY CARE TEACHING HOSPITAL
Background: Advancement in pharmacotherapy leading the new drug discovery for the clinical problem, as well as it’s also exploring the clinical applications and Drug-Related Problem (DRP). DRP is an event or circumstances, which involving drug treatment that interfere or potentially interferes with patient achieving an optimum outcome of medical care. DRP cause significant morbidity and mortalit...
FORMULATION DEVELOPMENT OF MICROSPONGE BASED DELAYED RELEASE DOSAGE FORM OF LANSOPRAZOLE
The aim of study is to develop microsponge based delayed release dosage form, technique used to manufacture microsponge was quasi emulsion diffusion technique. Eudragit L 100 and Eudragit S 100 polymer is used to incorporate lansoprazole in microsponge. Lansoprazole is acid labile drug hence release of lansoprazole was delayed from acid environment. Microsponge contains porous polymeric microspher...
ANTI-INFLAMMATORY AND IMMUNOMODULATORY ACTIVITY OF ETHANOL EXTRACT OF ALOE VERA GEL
The current treatment of inflammation includes NSAIDs, selective COX-2 inhibitors, glucocorticoids and anti-TNFα has peptic ulcer, renal and hematological toxic side effects as well as some of these drugs are more expensive. Hence it is necessary to evaluate the new cost effective as well as less toxic drug. Aloe vera showing a lots of promise and hence researcher all over are trying to harness t...