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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 13 (2022) - Issue 6, June

Review Articles

 
Title
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1.

A REVIEW ON THE MITOCHONDRIAL DYSFUNCTION IN SPORADIC PARKINSON’S DISEASE

Parkinson’s disease is the second most common progressive, age-linked neurodegenerative disorder. The sporadic form of the disease is usually idiopathic, where mitochondrial dysfunction is its major hallmark. Mitochondria are multifunctional dynamic organelles that carry out major cellular functions that get damaged by reactive oxygen species, deposition of lewy bodies, dopaminergic neuronal cel...

Saniya Tabassum and Anjali Raj *

Department of Pharmacology, The Oxford college of Pharmacy, Hongasandra, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2211-20

2211-2220

730

422

2.

REVIEW ON ACTIVITY OF CANNABIS TREATMENT ON PARKINSON’S DISEASE

As new treatments and medication are growing rapidly, neurologists are also toward expanding treating patients with idiopathic Parkinson's disease and facing questions regarding cannabis as a treatment elective, particularly for levodopa-safe Parkinson's symptoms. Cannabinoids compounds like delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) are the most abundant chemicals present. Whereas T...

Douglas Zorinmawia Chhakchhuak, G. Swetha Saniya Tabassum and Anjali Raj *

Department of Pharmacology, Pharmacy # 6/9, 1st Cross, Begur Road, Hongasandra, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2221-29

2221-2229

385

202

3.

SCREENING MODELS OF ANTI-PARKINSONIAN AGENTS

Parkinson’s disease (PD), identified as the second most common neurodegenerative disorder, is a progressive disease that impairs the ability to control voluntary movements mainly. According to the findings of the pathogenesis of PD, lesions in dopaminergic innervation of the basal ganglia cause degeneration of neurons in the substantia nigra and thus leads to loss of striatal dopamine level. Hen...

V. G. Kanase *, P. M. Pandagale and S. M. Dani

Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2230-41

2230-2241

332

186

4.

OROXYLUM INDICUM: AN OVERVIEW

Oroxylum indicum (O. indicum), commonly known as the Indian trumpet tree, belonging to the family Bignoniaceae, is a medicinally important, small, or medium-sized plant used to treat various diseases and also has its importance in the traditional system of medicine. Various parts of the plant have been proved to possess useful pharmacological activities. It is native to the Indian subcontinent, ex...

V. G. Kanase *, P. M. Pandagale and S. M. Dani

Department of Pharmacology, Oriental College of Pharmacy, Sanpada, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2242-50

2242-2250

388

175

5.

A SYSTEMATIC REVIEW ON DRUG REPOSITIONING: A NEW METHODOLOGY TO DRUG DISCOVERY

At a time where we understand that new drug discovery and development involves significant cost, expensive products and is the slow-paced process, an innovative idea called ‘Drug Repositioning’, which basically means repurposing of old drugs to treat diseases including both common and rare are being increasingly attractive as it provides drug development in a sustainable cost, time efficiently...

Abhilash Poudyal, Barsha Subba and Sonam Bhutia *

Government Pharmacy College Sajong, Government of Sikkim, Sikkim University, Sajong , Sikkim, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2251-62

2251-2262

380

159

6.

SALVIA HISPANICA (CHIA) SEEDS – A REVIEW ON PHARMACOLOGICAL BENEFITS, NUTRACEUTICAL PROPERTIES, EXTRACTION METHOD AND APPLICATIONS

The plant Salvia hispanica belongs to the family Lamiaceae, a highly valued medicinally important seed, commonly known as chia seeds. About 75% of the fats in chia seeds consist of omega-3 alpha-linolenic acid (ALA), while about 20% consist of omega-6 fatty acid. Omega-3s play an important role in sharpening memory and improving mood. Chia seeds also contain polyunsaturated fatty acids, dietary fi...

V. G. Kanase *, S. M. Dani and P. M. Pandagale

Department of Pharmacology, Oriental College of Pharmacy, Sector 2, Behind Sanpada Railway Station, Sanpada West, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2263-73

2263-2273

148

121

7.

PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITIES OF THEVETIA PERUVIANA: A REVIEW

In any nation's public health care system, plants play an essential role in therapeutic treatment. The plant Thevetia peruviana is an evergreen ornamental dicotyledonous shrub belonging to the family Apocynaceae. Thevetia peruviana is widely distributed in Central and South America and Asian countries, especially in India and Srilanka. Alkaloids, flavonoids, steroids, terpenoids, tannins, saponins...

Triksha Sharma, Jaswinder Kaur * and Gurinder Singh

G. H. G Khalsa College of Pharmacy, Gurusar Sadhar, Distt. Ludhiana, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2274-82

2274-2282

175

111

8.

AN OVERVIEW ON QUALITY BY DESIGN IN PHARMACEUTICAL PRODUCT DEVELOPMENT

The concept of Quality by Design reflects current global regulatory thinking related to pharmaceutical products. The pharmaceutical industry needs to improve its performance. Newer technologies need to be implemented that can effectively reduce the cost and, at the same time, improves product quality. Quality by design (QbD) is the best solution to build quality in all pharmaceutical products. The...

P. N. Mallikarjun *, Pooja Kumari, S. Manoj Kumar and G. Sowmya

Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2283-93

2283-2293

181

113

9.

MICROSPHERES: A NOVEL APPROACH FOR DELIVERY OF ANTIHYPERLIPIDEMIC DRUGS

Microsphere drug delivery is a novel drug delivery approach for sustaining and controlling the rate and release of active pharmaceutical ingredients. Microspheres are the choice of drug delivery for delivering the drug at a specific site to release the encapsulated drug to treat various diseases. Microspheres drug delivery is an attractive dosage form in terms of its flexibility and sustaining the...

Akbal Ahmad * and Abadhesh Kumar Niranjan

Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2294-02

2294-2302

140

95

10.

VARYING ANORECTAL DISORDERS: THEIR REMEDIES

Anorectal disorders are often perceived in surgery practice and often reside with pain with shifting vigour. Endeavour has been made to lessen pain and avoid ligature. Minuscule hospital stay with early return to work is the main aim of developing newer techniques in the management of anorectal diseases. Diverse modalities with the main tensity on surgical interceding for managing more common anor...

Sidhartha Jyoti Bora

Royal School of Pharmacy, The Assam Royal Global University, Betkuchi, NH-37, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2303-11

2303-2311

140

75

11.

THERAPEUTIC RELEVANCE OF AEGLE MARMELOS: A REVIEW

Aegle marmelos, commonly known as Bael or Bilva, is a traditional tree belonging to the family Rutaceae with enormous value in ethnobotany, Ayurveda, and has been used since time immemorial for its spiritual significance as an offering to Lord Shiva while worshipping. Looking at its religious perspective and medicinal benefits, people have conserved trees of Bael in sacred groves. It is a sub-trop...

Swati Jain *, Ahmad Shamim and Farooqui Nasiruddin Ahmad

Translam Institute of Pharmaceutical Education & Research, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2312-19

2312-2319

147

81

Research Articles

 
Title
Views
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Cited
12.

FUNGICIDAL ACTIVITY OF FIVE DISINFECTANTS ON ISOLATES OF CANDIDA SPECIES

Determine the fungicidal activity of five disinfectants on Candida auris of clinical and environmental origin.  Assess the fungicidal efficiency of each disinfectant on the microorganism.  Calculate the percentage of efficiency (% E) of each disinfectants on Candida strain and determine the specific death rate (k) and decimal reduction time for microorganisms.  Analytic and experimental researc...

Helena Lucía Martínez-Bajaire, Claudia Marcela Parra, Jorge Alberto Cortes and Janeth Arias Palacios *

Biotechnology Ambiental and Industrial Microbiology Group, Internal Medicine Department, Pontificia Universidad Javeriana, Faculty of Sciences, Department of Microbiology, Bogota, Colombia.

DOI: 10.13040/IJPSR.0975-8232.13(6).2320-26

2320-2326

368

204

13.

COMPARATIVE STUDY OF THE PROTECTIVE EFFECT OF THE LEAVES OF MURRAYA KOENIGII AND CENTELLA ASIATICA IN EXPERIMENTALLY INDUCED INFLAMMATORY BOWEL DISEASE IN ANIMALS

Ulcerative colitis was defined as a common intestinal infla-mmatory disease characterized by upregulation of pro-inflammatory cytokines and oxidative stress. The leaves of Murraya koenigii and Centella asiatica had been used in traditional medicine to treat the disease. The present study aimed to perform a comparative protective efficacy evaluation between Murraya koenigii and Centella asiatica on...

U. Choudhury *, P. Bordoloi, K. N. Dutta, L. Nath, M. Lahkar and B. J. Sahariah

Department of Pharmacology, Guwahati Medical College and Hospital, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2327-33

2327-2333

267

148

14.

LEUCAS ASPERA (WILD.) LINK ROOTS EXTRACT SECONDARY METABOLITES BESTOW ANTIOXIDANT, ANTI-BACTERIAL PROPERTIES AND INDUCE CELL CYTOTOXICITY TO HUMAN BREAST CANCER CELLS, MCF-7 BY APOPTOSIS

Leucas aspera species, auspicious in many cultures worldwide, are sources of novel bioactive secondary metabolites. The mechanism by which they exhibit therapeutic potential via antioxidant, antimicrobial and apoptotic properties is scant. The main objective of the current study was to evaluate the properties of activity-guided fractionated root methanol extract. As the methanol extract exhibited ...

Chaithra Mysore Lakshminarayanan and Shailasree Sekhar *

Institution of Excellence, Vijnana Bhavana, University of Mysore, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2334-43

2334-2343

259

117

15.

EVALUATION OF ERYTHROPOIETIN AS NEUROPROTECTANT IN ALCOHOL-INDUCED PERIPHERAL NEUROPATHY IN RATS

Alcoholic peripheral neuropathy is a potentially incapacitating complication of long-term excessive consumption of alcohol characterized by pain and dysesthesias, primarily in the lower extremities. The neurological effects of ethanol consumption are complex, encompassing both the central and peripheral nervous systems. It breaks into acetaldehyde which impairs and destroys the majority of neurona...

K, Arpitha, M. G. Hariprasad *, M. G. Mubasheera and Apurwa Dhavale

Department of Pharmacology, KLE College of Pharmacy Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2344-57

2344-2357

265

124

16.

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) STUDIES OF SUBSTITUTED BENZIMIDAZOLE ANALOGUES WITH POTENT ANTIBACTERIAL ACTIVITY

Computational chemistry is a robust and economical tool for designing and developing potent therapeutic molecules. Benzimidazole and its analogues are compounds with a unique pharmacophore that derives its application as broad-spectrum antimicrobial agents. A quantitative structure-activity relationship (QSAR) study was performed using a data set of 28 benzimidazole analogues with antimicrobial ac...

Shambhavi Parab, Chandani Muleva, Jinal Shah, Bhairavi Murkute and Madhura Vaidya *

Department of Pharmaceutical Chemistry, MET Institute of Pharmacy, Bhujbal Knowledge City, Bandra Reclamation, Bandra West, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2358-66

2358-2366

326

143

17.

EVALUATION OF ANTIOXIDANT PROPERTY OF SELECTED REGIONAL MEDICINAL PLANTS USING DPPH, ABTS AND H2O2 AND TPC & TFC METHODS

The various medicinal plants have been used in the Ayurvedic medicine system to treat various diseases for a long period. The plant shows first-line defense mechanisms by secondary metabolites against different diseases and foreign particles to build immunity. This metabolite are classified as phyto & polyphenolic compound. Antioxidants play an important role in humans due to the presence of t...

Mradu Gupta *, Anumita Dey and Sushmita Majumder

Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2367-79

2367-2379

131

87

18.

GC-MS ANALYSIS OF METHANOLIC EXTRACT OF UROCHLOA DISTACHYA (L.) T. Q. NGUYEN, LEAVE

Urochloa distachya (Poaceae), commonly known as Signal grass 20-60 cm long found in tropical Asian origin, Africa, and other countries. Generally, it has been used in fodder, animal feed etc., and least and no therapeutic activities were reported. The present study was established to identify the phytochemicals by using GC-MS of the U. distachya leaves part. The leaves part of the plant was extrac...

Smrutiranjan Dash *, Ashutosh Meher, Srimanta Kumar Dash, Chandan Das and Santosh Kumar Dash

Department of Pharmacology, The Pharmaceutical College, Samaleswari Vihar, Tingipali, Barpali, Bargarh, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).2380-94

2380-2394

161

144

19.

EFFECTS OF GIMA LEAVES (GLINUS OPPOSITIFOLIUS) ON HAEMATOLOGICAL PARAMETERS OF ADULT HUMAN

Glinus oppositifolius (Linn) is a branched herb containing linear to obovate, opposite leaves with greenish flowers, and it belongs to the molluginaceae family. This bitter leafy vegetable is known as gima shak in West Bengal, Assam & Bangladesh. This leaf contains various bioactive components which provide protection against diabetes, hyperlipidaemia, joint pain, inflammation, diarrhea, skin...

Soumi Pal Choudhury * and Kazi Layla Khaled

Department of Home Science, University of Calcutta, 20B, Judges Court Road, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2395-98

2395-2398

127

68

20.

IDENTIFICATION AND QUANTIZATION OF OLEANOLIC ACID IN STEM AND ROOTS OF ACHYRANTHES ASPERA USING VALIDATED HPTLC METHOD

Objective: Active chemical constituent in plants exhibits pharmacological action. Hence this research work aimed to identify and quantitate oleanolic acid. Methods: A simple, high-performance thin-layer chromatography (HPTLC) is developed and validated to identify and quantify oleanolic acid. The extracts were spotted as bands on aluminum TLC plates which were pre-coated with silica gel. Different...

Y. Nehete Jitendra *, C. Fegade Varsha and R. Narkhede Minal

M. G. V’s Pharmacy College Krishna Nagar, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2399-04

2399-2404

156

91

21.

EVALUATION OF ANTIDIABETIC ACTIVITY OF PICRORHIZA KURROA ROYLE EX. BENTH. – IN-VITRO AND IN-VIVO

During the past few years, diabetes has been one of the leading metabolic disorders. It occurs when the body does not produce enough insulin or the body cells are not efficient enough to take up the insulin. This increases blood glucose levels that affect the body system, particularly blood vessels and nerves. Due to the side effects of allopathic medicines, individuals are searching the other alt...

Nirja *, Richa and M. L. Sharma

Department of Biosciences, M. L. S. M. College Sundernagar Chaterokhri, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2405-11

2405-2411

138

84

22.

FORMULATION, OPTIMIZATION AND EVALUATION OF FEBUXOSTAT LOADED SNEDDS FOR TREATING GOUT

Febuxostat (FXT), used for treating gout, is poorly soluble and is susceptible to enzymatic degradation when administered as tablets. The current study aims to formulate, optimize and develop a stable Liquid self-nanoemulsifying drug delivery system (L-SNEDDS) and Solid SNEDDS to improve solubility, resulting in enhanced bioavailability and further to formulate Self-Nano emulsifying Osmotic Pump T...

Rita Lala * and Bhagyashree Chande

Department of Pharmaceutics, Principal K. M. Kundnani College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2412-25

2412-2425

133

86

23.

ANTIFUNGAL ACTIVITIES OF PUNICA GRANATUM RIND ALCOHOLIC EXTRACT AGAINST SOME NON-ALBICANS CANDIDA SPP.

Punica granatum (Pomegranate) external peel extract in 70% ethanol was challenged against two non-albicans Candida spp. to find out it’s possible antifungal effects in disc diffusion technique as well as in microtiter dilution to find out MIC levels. Although both showed sensitivity zones in disc diffusion technique at 100 mg/mL concentration of the extract, at lower concentrations (<16.6 mg/...

Somdatta Maiti, Bhaskar Narayan Chaudhuri *, Partha Guchhait and Satadal Das

Department of Microbiology, Peerless Hospitex Hospital and Research Center Ltd. 360, Panchasayar, Kolkata, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2426-31

2426-2431

139

76

24.

SCREENING OF RANDIA DUMETORUM LAMK. EXTRACTS FOR ANTI-INFLAMMATORY ACTIVITY USING MOUSE MODEL OF HCL-INDUCED ALI

Acute Lung Injury (ALI) and its more severe form Acute Respiratory Distress Syndrome (ARDS) is a clinical syndrome with a high mortality rate (27-41%). There is no pharmacological therapy for ALI treatment so far because of the complex mechanism and involvement of multiple pathways. So, the present study was designed to test the role of different extract/fractions of fruits of a traditional plant ...

Arun Narota, Gulsheen, Anupam Sharma, Ashwani Kumar and Amarjit S. Naura *

Department of Biochemistry, BMS Block, Panjab University, Chandigarh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2432-40

2432-2440

127

74

25.

A MOLECULAR MODELING STUDY OF PHYTOCONSTITUENTS ANALYSED VIA GC-MS TECHNIQUE IN THE RHIZOME PART OF HEDYCHIUM SPICATUM (ZINGIBERACEAE)

Hedychium spicatum is one of the plant species reported from the northern Himalayan ranges of India, belonging to the family Zingiberaceae, with ethnobotanical values and is well-known for their ethnomedicinal applications. In the present investigation, pet ether and ethanolic rhizome extracts of Hedychium spicatum were Analyzed by gas chromatography-mass spectrometry (GC–MS) to identify the imp...

Roopal Mittal *, Vivek Verma and Harjinder Kaur

I. K. Gujral Punjab Technical University, Jalandhar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2441-49

2441-2449

127

80

26.

PREVALENCE AND PREDICTORS OF DRUG-RELATED PROBLEMS AMONG MEDICAL WARD PATIENTS IN A SECONDARY CARE REFERRAL HOSPITAL: A PROSPECTIVE HOSPITAL-BASED INTERVENTIONAL STUDY

Drug-Related Problem (DRP) affects the hospital stay, healthcare budget, quality of life, morbidity, and mortality. The study aims to assess the prevalence and predictors of DRPs in hospitalized patients and provide intervention. A prospective interventional study was conducted in the in-patient medical department of the NGO hospital. A total of 310 subjects were enrolled and screened for the pres...

Samhitha Y. Reddy * and Somashekar K. Reddy

Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2450-57

2450-2457

105

83

27.

A QUESTIONNAIRE STUDY ON THE KNOWLEDGE, ATTITUDE AND THE PRACTICE OF COVID-19 AMONG MEDICAL STUDENTS IN A TERTIARY CARE HOSPITAL IN AJMER, RAJASTHAN

Background: Covid-19 has become a global threat. All most all the countries are facing this pandemic. This pandemic has greatly affected the medical education and medical students who are tomorrow's doctors. So, they need to have a wide awareness regarding the knowledge, attitude, and practice towards this Covid-19 infection. Objective: To study the knowledge, attitude, and practice of medical stu...

Arun Kumar Sharma * and Vandana Goyal

Department of Pharmacology, J. L. N. Medical College, Ajmer, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2458-64

2458-2464

120

102

28.

GENERAL INVESTIGATIONS ON THE HEPATOPROTECTIVE POTENTIAL OF PHYLLANTHUS NIRURI

Phyllanthus niruri commonly known as Keezhanelli is traditionally used as a medicinal plant in many parts of the world. In this study, phytochemical screening was the hepatoprotective potential of the plant investigated. Two plant forms, namely, dry powder and fresh leaves were used. Aqueous and methanolic extracts were prepared from both forms, and the experiments were carried out. The hepatoprot...

Kavitha G. Singh *, N. Nandhini and Nasmah Maqsood

Mount Carmel College (Autonomous), 58, Palace Road, Ashok Layout, Vasanth Nagar, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2465-70.

2465-2470

123

66

29.

ANTIDEPRESSANT EFFECT OF IBANDRONATE ON DEPRESSION MODELS

This study was designed to evaluate and compare the Antidepressant effect of Ibandronate with Amitriptyline on depression models in albino mice. Eighteen Swiss albino mice weighing 20-25 grams were selected and divided into three groups of six animals each. Group 1: Normal Saline- 0.5 ml, Group 2: Amitriptyline - 39 mg/kg, Group 3: Ibandronate 0.325 mg/kg administered orally every day for 30 days....

V. S. Harish Kumar *, Shravani D. Patil, A. N. Pradeep, B. E. Pradeep, M. S. Raghu Prasada, K. G. Shivashankaramurthy and L. J. Kiran

Department of Pharmacology, S. S. Institute of Medical Sciences and Research Centre, Davanagere, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2471-75

2471-2475

117

84

30.

DESIGN SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BENZHYDRYL PIPERAZINE DERIVATIVES AS A NEW CLASS OF ANTI-CONVULSANT AGENTS

A novel series 3(a–d) 1-(4-benzhydryl piperazin-1-yl)-3-(di substituted) propan-1-one &1-(4-benzhydrylpiperazin-1-yl)-3-(piperidin-1-yl) propan-1-one (3e) & 1-(4-benzhydrylpiperazin-1-yl)-3-morpholinopropan-1-one (3f) compounds have been synthesized and screened for its anticonvulsant and neurotoxic activity, After i.p. injection to rat at doses of 30, 100, and 300 mg/kg body weight. Syn...

Kuldeep Singh *, Ashok K. Shakya, Shashi Alok, Shom Prakash Kushwaha and Piyush Kumar

Faculty of Pharmacy, Integral University Kursi Road, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2476-83

2476-2483

118

65

31.

A STUDY ON SERUM UREA AND CREATININE IN DIAGNOSED CASES OF SUBCLINICAL HYPOTHYROIDISM

Hypothyroidism is a progressive disorder characterized by varying degrees of thyroid failure, metabolic consequences, and hemodynamic changes that decrease renal plasma flow and glomerular filtration rate, increasing serum creatinine level. Therefore, the present study aimed to evaluate and analyse the level of serum urea, creatinine and thyroid function tests in cases of subclinical hypothyroidis...

Ajit Kumar Yadav, Priyanka Thapa Manger * and Richa Awasthi

Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2484-87

2484-2487

125

80

32.

EFFECT OF VITAMIN D ON THE OXIDATIVE STRESS PARAMETER (MDA) IN HYPOTHYROID PATIENTS

Background: Hypothyroidism is a metabolic disorder. Vitamin D is known to improve the impact of autoimmune diseases; hence, vitamin D supplements and adjuvant therapy can improve hormonal and metabolic imbalance along with oxidative stress. The study aims to determine the effect of Vitamin D on the oxidative stress parameter in hypothyroid patients compared to controls and hypothyroid subjects be...

N. Ratna Kumari *, Vijayalakshmi and G. S. Prema

Department of Physiology, Shadan Institute of Medical Sciences, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2488-91

2488-2491

121

92

33.

EFFECT OF DIALLYL DISULFIDE (DADS) ON GLUCOSE UTILIZATION IN DIABETIC ERYTHROCYTES

Background & objectives: Diallyl disulphide (DADS) is an active component of garlic that has been claimed to have hypoglycemic effect and are beneficial in achieving glycemic control in diabetes mellitus (DM). The present study was conducted to assess the glucose utilization in erythrocytes in diabetic subjects after the exposure of DADS. Methods: The blood samples were collected from diabetic...

Aishwarya Rao, Aditi Nagendra, C. V. Yogaraje Gowda, R. T. Kashinath and Prashanthkumar Goudappala *

Department of Biochemistry, Shivamogga, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2492-96

2492-2496

105

66

34.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF METFORMIN AND SAXAGLIPTIN

The present study aims to develop a verse phase HPLC method for the simultaneous estimation of Metformin and Saxagliptin. In bulk and pharmaceutical dosage form and to validate the proposed method in accordance with ICH guidelines for the intended analytical application. Multiple trials were run to Metformin and Saxagliptin, get eluted with good peak symmetric properties. Mobile phase Phosphate bu...

Mahnoor Fatima * and S. Roshan

Azad College of Pharmacy, Moinabad, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2497-07

2497-2507

147

99

35.

ETHNOMEDICINAL IMPORTANCE OF RAINY SEASON WEEDS OF JHANSI DISTRICT

An ethnomedicinal exploration of weeds of Jhansi district, located in the state of Uttar Pradesh in India, has been carried out to identify and find out the use of weeds to treat different ailments. Folklore people living in remote areas do not have easy access to hospitals or medical facilities, so they depend on the plants and weeds present in their surroundings to treat various diseases or phys...

Sippy Dassani, Tirthesh Kumar Sharma * and Jyoti Richhariya

Department of Botany & Industrial Microbiology, Bipin Bihari College, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2508-17

2508-2517

134

74

36.

ANTIMICROBIAL AND ANTI-INFLAMMATORY POTENTIAL OF THE LEAF EXTRACTS, COLUMN FRACTIONS AND COMPOUNDS OF THE MEDICINAL PLANT JASMINUM FLEXILE VAHL

The medicinal plant Jasminum flexile is reported in traditional medicine as an antidiabetic and anti-inflammatory agent. There is no scientific report on the antibacterial and anti-inflammatory activity of extracts of Jasminum flexile. This study investigated the antibacterial and anti-inflammatory potential of the hydroethanol extract of leaves of Jasminum flexile, its column fractions and consti...

P. Rajasri Bharathi * and Shubashini K. Sripathi

Department of Chemistry, School of Physical Sciences and Computational Sciences, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2518-24

2518-2524

137

98

37.

CLINICAL STUDY ON THE IMMUNOMODULATORY EFFECT OF NIDIGDHIKADILEHA ON PRANAVAHA SROTO DUSHTI W. S. R. UPPER RESPIRATORY TRACT INFECTIONS IN CHILDREN

Aim of study: A Randomized controlled trial was planned to evaluate the Clinical efficacy of Nidigdhikadileha an Ayurveda multi-dimensional herb preparation in children suffering from Recurrent Respiratory tract infection in children. Nidigdhikadileha contains Nidigdhika (Solanum Xanthocarpum), Pippali (Piper longum), Amrita (Tinospora cardifolia), and Nagar (Zingiber officinale). All these drugs ...

Amandeep

Department of Kaumarbhritya-Balroga, National Institute of Ayurveda, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2525-33

2525-2533

141

84

38.

DE RITIS RATIO OF COVID-19 PATIENTS ADMITTED DURING FIRST, SECOND AND THIRD WAVE

Background: To date, the 2019 novel coronavirus pneumonia (COVID-19) is the greatest public medical issue in the world. World Health Organization (WHO) declared this outbreak a “public health emergency of international concern” on January 31, 2020. Therefore, it bodes well to look for a potential biomarker that could quickly and effectively distinguish serious cases early. Of the total confirm...

Saurabh Kumar Deo, Nitin Tangri, Neeru Bhaskar and Vijay Chaudhary *

Department of Biochemistry, M. M. Medical College and Hospital, Laddo, Sultanpur Road, Kumarhatti, Solan, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2534-38

2534-2538

128

80

39.

ANTIADIPOGENIC, FREE RADICAL SCAVENGING AND ANTI-INFLAMMATORY ACTIVITY OF NIGELLA SATIVA SEED FRACTIONS

Obesity and overweight have recently drawn greater attention due to their central role in the rapid increase of metabolic syndrome disorders. The research pursuit for exploring novel and effective therapeutic alternatives to deal with obesity ailments and oxidative stress has received immense interest. In this study, different solvent fractions of Nigella sativa (N. sativa; Black cumin) seeds were...

Ramineedu Keerthi, Reddy Sankaran Karunakaran and Meriga Balaji

Department of Biochemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2539-49

2539-2549

99

79