Volume 7 (2016) - Issue 6, June
Review Articles
GOLD NANO-CONJUGATES: A LEAP IN CANCER TREATMENT
The use of nanoparticles as drug delivery and targeting agents has led to immense progress in the field of biomedicine and diagnostics. Likewise gold nanoparticles can be conjugated with various molecules, for instance, to plasmid DNA for gene therapy, to various drugs for antibacterial and anticancer properties, to several antibiotics and peptides for immunological and diagnostic purposes. The re...
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SUICIDE RISKS AMONG ADOLESCENTS: A LOOK BEHIND THE BLACK CURTAIN
This review article investigates the prevalent existence of suicide along with its risk factors and contributing factors leading to the culmination of them all, in an attempt to look behind the black curtain. Suicide is the result of an unbalanced scale between the good and bad. Every year 300,000 teenagers attempt and succeed at suicide worldwide. A set of emotions and unpleasant thoughts develop...
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TRANSDERMAL DRUG DELIVERY SYSTEM: A REVIEW
A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a con...
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AN APPROACH TO BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION: A REVIEW
Bioanalytical method development is the process of creating a procedure to enable a compound of interest to be identified and quantified in a biological matrix. A compound can often be measured by several methods and the choice of analytical method involves many considerations. Analysis of drugs and their metabolites in a biological matrix is carried out using different extraction techniques like ...
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ORAL OSMOTIC DRUG DELIVERY SYSTEM: A REVIEW
Osmosis is physical phenomenon that has been comprehensively studied by scientist in various disciplines of science and engineering. Osmotic devices are the most promising strategy based system for controlled delivery of drug. Conventional drug delivery has little control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern ...
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A REVIEW ON PHARMACEUTICAL PREFORMULATION STUDIES IN FORMULATION AND DEVELOPMENT OF NEW DRUG MOLECULES
Preformulation is a group of studies that focus on the physicochemical properties of a new drug candidate that could affect the drug performance and the development of a dosage form. This could provide important information for formulation design or support the need for molecular modification. Every drug has intrinsic chemical and physical properties which has been consider before development of p...
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Research Articles
PRE-FORMULATION CHARACTERIZATION OF CHELATED AMINO ACID COMPLEXES
Amino acid chelated complexes were synthesized and characterized to determine their purity. The purity of the complexes was found to be ranging from 42-75%. The HPLC method for determination of free amino acid content in the complexes was developed and validated and found to be linear, precise and accurate within concentration range of 0.157 mg/mL to 20.14 mg/mL. The method was used to estimate ...
7297
1850
A DERIVATIVE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF METHYLXANTHINES AND TANNINS IN GUARANA BULK (PAULLINIA CUPANA)
A method using derivative UV spectrophotometry was developed and validated for the determination of methylxanthines and tannins in guarana bulk, using caffeine and catechin as markers. The spectra were obtained using first order derivatization, Δλ=20.000, and scale factor of 10. The quantification of actives was performed using wavelengths of 244 and 277 nm for catechin and caffeine, respectivel...
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RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD A FOR ESTIMATION OF LOSARTAN POTASSIUM UNDER STRESS CONDITION AND TABLET DOSAGE FORM
Losartan potassium, a highly effective blood pressure lowering agent, has widely used for treatment of hypertension. Simple, economic, selective, and precise and stability indicating HPLC method has been developed and validated for analysis of losartan potassium in bulk drug and formulation dosage form. In order to optimize more one response at time, the chemo metric approach which includes 23...
3979
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DESIGN AND SYNTHESIS OF NOVEL MYCOBACTERIUM TUBERCULOSIS DHFR INHIBITORS
A series of 2,4-diaminotriazines were synthesized as Mycobacterium tuberculosis(Mtb) dihydrofolatereductase (DHFR) inhibitors. These derivatives were evaluated in whole cells by employing resazurinmicrotitre plate assay (REMA) against MtbH37Rv. Further, these were tested against other gram positive and gram negative bacterial strains to check specificity for Mtb. Cytotoxicity assessment was perfor...
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TEMPLATE SYNTHESIS AND CHARACTERIZATION OF LANTHANIDE(III) COMPLEXES OF 21-MEMBERED UNSYMMETRICAL PENTAAZA MACROCYCLIC SCHIFF BASES BEARING PENDANT ARM. IDENTICAL FRAME WORK: PART II
A series of discrete mononuclear lanthanide(III) complexes of H2L1 [Ln(H2L1)(NO3)2]NO3.nH2O (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Y; n = 1 for Ce; n = 2 for La, Sm, Gd and Y; n = 3 for Pr, Nd, Eu, and Tb) have been prepared by the condensation of Schiff-bases with the precursor compounds namely, 2,6-diformyl-4-methylphenol, 1,5-diamino-3-azamethypentane and 4,5-dimethyl-1,2-phenylenediamin...
3921
1706
POSSIBLE RETRIEVAL OF ORGANOCHLORINE INDUCED RENAL TOXICITY IN FISH BY AQUEOUS ROOT EXTRACT OF WITHANIA SOMNIFERA: IN VIVO STUDY
The present study was aimed to assess the reno-protective impact of aqueous extract of root of Withania somnifera (WSR) commonly known as Ashwagandha against organochlorine induced renal toxicity in fish Clarias batrachus (Linn.).Fishes were exposed to 4ppb concentration of commercial brand Endocel, an organochlorine pesticide for one week and two week to prepare the toxic model. These toxic group...
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SIMULTANEOUS QUANTIFICATION OF KAEMPFEROL AND QUERCETIN IN MEDICINAL PLANTS USING HPTLC
Kaempferol and quercetin are the flavonoids which are widespread in fruits and vegetables exhibiting important biological activities. A simple and precise HPTLC method was developed and validated for simultaneous determination of kaempferol and quercetin in herbal drug extracts of Podphyllum hexandrum and Cassia angustifolia. The HPTLC of flavonoids was performed with toluene: acetone: formic acid...
4294
1595
ANTIDIABETIC, HYPOLIPIDEMIC AND HISTOPATHOLOGICAL ANALYSIS OF ZINGERONE IN STREPTOZOTOCIN INDUCED DIABETIC RATS
The effects of zingerone, on antidiabetic and hypolipidemic potential in streptozotocin-induced diabetic rats were investigated in the present study. Diabetes mellitus was induced by a single intraperitoneal administration of streptozotocin (40 mg/kg bwt). Five days after STZ administration, diabetic rats received zingerone (10 mg/kg bwt) orally for 30 days. Metformin (Met) was used as reference d...
4667
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SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS ANTI-INFLAMMATORY AGENTS
All the newly synthesized Coumarin derivatives have shown considerable anti-inflammatory activity. In the present research work, we synthesized a series of novel Coumarin derivatives. The Coumarin derivatives such as substituted 7-hydroxy-4-methyl-2H-chromen-2-one and substituted 6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one were synthesized from substituted benzoyl chloride. The chemical structure...
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COMPARATIVE IN-VITRO EVALUATION OF COMMERCIAL SIMVASTATIN TABLETS (20 MG)
The availability of several brands of Simvastatin tablets in Libyan pharmacies today places health practitioners in a problem of generic substitution. The aim of the present study was the evaluation and comparison between four different Simvastatin brands, which are commercially available in the Libyan market produced by various pharmaceutical companies with different trade names. The physicochemi...
5424
1446
EXPLORING WOMEN’S AWARENESS ABOUT BREASTFEEDING AND HEALTH BENEFITS USING A CROSS-SECTIONAL SURVEY IN DHAKA CITY, BANGLADESH
This cross-sectional questionnaire based study was conducted among 200 randomly selected child bearing mothers aged 16 to 40 to evaluate their awareness regarding breastfeeding and its health benefits in urban and slum area of Dhaka city from July to December 2013. The study showed that about 46% of respondents completed higher secondary education or more and about 27% were illiterate. A significa...
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HPTLC METHOD DEVELOPMENT AND VALIDATION OF CINNARIZINE IN BULK AND MARKETED FORMULATION
High performance thin layer chromatography (HPTLC) offers many advantages over HPLC. It reduces the cost of analysis as compared to HPLC. The mobile phase consumption per sample is extremely low in HPTLC, hence reducing the acquisition and disposal cost. Considering the cost and suitability of analysis for estimation of cinnarizine in bulk and its marketed formulation, HPTLC method was developed a...
4033
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EVALUATION OF PHYTOCHEMICALS AND IN VITRO PHARMACOLOGICAL ACTIVITY OF ACACIA SINUATA PLANT LEAVES
Objective: The present work is aimed to screen phytochemicals, in vitro antimicrobial and antioxidant activity of the non polar and polar extracts of Acacia sinuata. Methods: Leaves of Acacia sinuata- were collected, dried and powdered. The powdered material is subjected to soxhlet extraction using various polar to non polar solvents and allowed for evaporation. The crude extracts thus obtained we...
4863
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MECHANISMS OF UROLOGIC COMPLICATIONS IN STREPTOZOTOCIN-INDUCED TYPE 1 DIABETES MELLITUS
Patients with DM are often afflicted by debilitating urologic complications. The main aim of this study is to investigate the effect of streptozotocin (STZ)-induced type I diabetes on contractile responses to numerous stimuli, intracellular cation concentrations and morphology in the rat. Adult rats (n=12) were humanely killed and detrusor muscles of urinary bladder located and excised rapidly a...
2682
994
ESTIMATION OF PHENOLIC COMPOUNDS BY RP-HPLC AND ANTIOXIDANT ACTIVITY IN LEAF AND STEM EXTRACTS OF BARLERIA PRIONITIS L.
In the present investigation phenolic contents and antioxidant potential of Barleria prionitis L. leaf and stem extracts were analyzed by in vitro antioxidant assays and RP-HPLC method. The results indicated that high amount of total phenolics were present in acetone extracts of leaf (20.22±0.57 mg of GAE/g) and stem (21.19±1.25 mg of GAE/g). Highest flavonoid content was observed in ethanolic (...
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DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PREGABALIN, METHYCOBAMIN, AND ALPHA LIPOIC ACID IN MULTICOMPONENT DOSAGE FORM
Objective: To develop and validate a novel and easy first order derivative spectroscopic method for the simultaneous determination of multicomponent dosage form which contains Methylcobalmine, Alpha lipoic acid and Pregabaline. Method: Measurement was achieved by selecting different Zero crossing points i.e ZCP for Methylcobalamine and Alpha lipoic acid at 436.24 nm, ZCP for Alpha lipoic acid and ...
3495
1219
A PRAGMATIC APPROACH ON COLONIC DELIVERY OF RIFAXIMIN USING POLYMER COATED MULTI-PARTICULATE SYSTEM
This study aimed to develop and optimize a multi-particulate formulation for colon targeted delivery of rifaximin by application of a functional coat of Eudragit L100 and Eudragit S100 mixture on the drug layered pellets. The rifaximin-excipients compatibility was confirmed with FTIR studies. Functional coat completely restricted drug release in pH 1.2 dissolution medium. Statistical optimizatio...
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AUGMENTATION OF TIL-CD3 IN ORAL CANCER: VARIATIONS IN RELATION TO STAGE AND GRADE OF DISEASE
Oral squamous cell carcinoma (OSCC) is often associated with a lymphocytic infiltrate that is believed to represent an in vivo immune reaction to the tumor cells. In this study, the tumor-infiltrating lymphocytes (TIL) associated with primary OSCC were characterized in hundred newly-diagnosed patients to determine the nature of the immune response to the primary tumor and to correlate it with stag...
2765
1224
SYNTHESIS OF THE HETEROCYCLIC HYDROXAMIC ACID DERIVATIVES FOR PDF INHIBITORS AS A ANTIBIOTICS
Peptide deformylase (PDF) is a mononuclear metal ion protein that is responsible for removing the N-formyl group of nascent proteins found in bacteria and chloroplasts in order for them to become mature proteins. From literature it was found that heterocyclic derivatives containing hydroxamic acid and hydroxyl amine exhibit good antibacterial and PDF inhibitory activity. Heterocycles bearing nitro...
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1375
EVALUATING ADJUNCTIVE ROLE OF PPI AS ANTI INFLAMMATORY AGENT IN KNEE OSTEOARTHARITIS: A PROSPECTIVE STUDY IN TERTIARY CARE HOSPITAL
Osteoarthritis (OA) is one of the main causes of disability worldwide. Patients are mostly treated with NSAIDS with PPI and H2 blockers, analgesics, opoids etc in everyday practice. In addition to anti-secretory effects, PPIs have anti-oxidant and anti-inflammatory actions in vitro. But the role of PPIs as anti-inflammatory agents remains to be explored. Aim: Present study was aimed to compare eff...
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DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLETS OF PROMETHAZINE THEOCLATE USING 32 FULL FACTORIAL DESIGN
This research work aimed at developing and optimizing fast dissolving tablets of Promethazine Thecolate by direct compression technique. In the investigation, a 32 full factorial design was used to investigate the joint influence of two formulation variables (amount of superdisintegrants): amount of sodium starch glycolate and crospovidone. The tablets were evaluated for its percent friability and...
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PICOGRAM LEVEL QUANTIFICATION OF VARENICLINE IN HUMAN PLASMA SAMPLES BY LC–ESI-MS/MS
The objective of this research was to develop and validate a simple, sensitive and specific Liquid Chromatography – Tandem Mass Spectrometry (LC–MS/MS) quantification of Varenicline in human plasma using Varenicline -D4 as Internal Standard (IS). The analyte was separated on a Zorbax SB-C18, 4.6 x 75 mm, 3.5 μm, 80 Å column with an isocratic mobile phase of 5mM ammonium formate: acetonitrile...
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STUDY OF VARIATION IN PRICE OF VARIOUS NSAIDS COMBINATIONS AVAILABLE IN INDIAN MARKET
Introduction: Non Steroidal Anti Inflammatory drugs are widely used drugs worldwide for various inflammatory conditions and acute as well as chronic pain conditions. In India large number of NSAIDs preparations are available in the market. Therefore choosing a NSAID becomes very difficult task for the prescribing physician. Objective: To evaluate the price variation of the different NSAIDs prepara...
4063
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ANTI-HYPERGLYCEMIC EFFECT OF CARALLUMA LASIANTHA EXTRACT ON HYPERGLYCEMIA INDUCED BY CAFETERIA-DIET IN EXPERIMENTAL MODEL
Caralluma lasiantha is a succulent plant belongs to Ascalpedaceae family. The objective of this study was to evaluate and to compare the anti-hyperglycemic effect of Caralluma lasiantha with Chromium Picolinate on hyperglycemia induced by Cafeteria-Diet in Wistar albino rats. Hyperglycemia was induced in experimental rats by feeding Cafeteria-Diet for a study period of 90 days. Caralluma lasiantha...
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STUDY OF NEUTRALIZATION OF ENZYMATIC ACTIVITY OF DABOIA RUSSELII VENOM BY VARIOUS PLANT EXTRACTS AND THEIR COMBINATIONS USING IN VITRO METHODS
Snakebite is an important cause of morbidity and mortality and is one of the major health problems in India. Russell’s viper (Daboia russelli) appears to be the commonest cause of fatal snakebite in many Asian countries and especially in the Indian subcontinent. Intravenous administration of anti venom serum neutralizes the systemic actions, but it is of little effect on the reversal of local sy...
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NUTRITIONAL EVALUATION OF ASIATIC MANGROVE RHIZOPHORA MUCRONATA – ITS PROXIMATE COMPOSITION, AMINO ACID PROFILES AND PHYSICO-CHEMICAL PROPERTIES
The present study explores the nutritional properties of R. mucronata leaves, an edible red mangrove which has been proven as an antidiabetic and as an alternative source of tea leaves and animal feed. Proximate composition, amino acid profiles and physico-chemical properties were analyzed to evaluate the nutritional property. Nutritional evaluation of R.mucronata illustrates it as a rich source o...
4290
1800
COMPARISON OF ANALGESIC EFFECT OF EPIDURAL ROPIVACAINE (0.2%) AND ROPIVACAINE (0.2%) WITH FENTANYL (4mcg/ml) IN POST OPERATIVE PATIENT OF TOTAL KNEE REPLACEMENT SURGERY
Introduction: Epidural anesthesia is the most commonly used technique for providing not only peri-operative surgical anesthesia but post-operative analgesia in lower abdominal and limb surgeries. Our study aimed to assess the comparison between ropivacaine(Group A) and combination of ropivacaine with fentanyl (Group B) in terms of their analgesic effect, hemodynamic stability, side effects and req...
3524
1365
ROLE OF DEFERASIROX, AN ORAL IRON CHELATOR IN PREVENTION OF ISCHEMIC REPERFUSION MYOCARDIAL INJURY IN ALBINO RABBITS
An experimental study was carried out after getting approval from institustional animal ethical committee to study the role of oral iron chelator, deferasirox in prevention of myocardial ischemic reperfusion injury in albino rabbits. Albino Rabbits of either sex were divided into two groups control (n=5) and test group (n=5), receiving deferasirox. Experiments were done using isolated heart perf...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME QUINOLINE DERIVATIVES
Cyclocondensation of 5-6 and 7-8 with chloroacetyl chloride in presence of triethylamine give 9-10 and 11-12 respectively. All the synthesized compounds 1-12 have been screened for their antibacterial as well as antifungal activities and compared with reference drugs streptomycin and fusidic acid respectively. These synthesized compounds were screened for their antibacterial activity against S. ...
4051
1544
EVALUATION OF MGIT OVER OTHER PHENOTYPIC METHODS FOR THE DETECTION OF PULMONARY AND EXTRAPULMONARY TB AT A TERTIARY CARE CENTRE IN NORTH INDIA
This study compares the performance of Mycobacterium Growth Indicator Tube (MGIT) culture against conventional Lowenstein Jensen (LJ) media and direct AFB smear examination in pulmonary and extra pulmonary tuberculosis specimens for isolation and drug sensitivity testing (DST) using solid (LJ) and liquid (BACTEC-MGIT-320) media at a tertiary care centre in North India A total of 132 consecutive cl...
4044
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 1,8-NAPHTHYRIDINES CONTAINING PYRAZOLINONE, PYRAZOLE, ISOXAZOLINONE, ISOXAZOLE AND PYRIMIDINE-2-ONES
Diazonium salt of 2-(p-aminophenyl)-1,8-naphthyridine (I) was coupled with active methylene compounds to afford the hydrazono-1,8-napthyridinyl (III-V) and azo(VI) derivatives. Hydrazono ethyl acetoacetate (III) and ethyl cyanoacetate (IV) derivatives on treatment with hydrazine and substituted hydrazine’s were later reacted with hydroxylamine HCl in the presence of ethanol followed by cycliza...
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1288
BACTERIOLOGICAL QUALITY OF CHLOROQUINE SYRUPS SOLD IN CALABAR MUNICIPALITY, NIGERIA
Bacteriological qualities of three different brands of chloroquine syrup (EZR, DMR and MBR) commonly sold in Calabar municipality, Nigeria were evaluated using standard microbiological techniques. Each brand was evaluated in duplicates and examined visually for possible abnormalities such as colour, turbidity and un-usual odour. This was followed by determination of viable cell count and identific...
3128
1409
A CASE CONTROL STUDY OF ANTIOXIDANT AND OXIDANT STATUS IN TUNISIAN RHEUMATOID ARTHRITIS PATIENTS
Rheumatoid arthritis is a chronic inflammatory disease with several triggers such as oxidative stress. The aim of this study was to assess the antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase), the total antioxidant status, lipid peroxidation (malondialdehyde) and homocysteine levels in patients with rheumatoid arthritis. The study pop...
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PHYTOCHEMICAL STUDIES OF TWO SELECTED UNANI MEDICINAL PLANTS OF KALABURAGI REGION, KARNATAKA, INDIA
The present work was designed to perform the comparative study between the seeds of two selected plants i.e., Butea monosperma & Nigella sativa. The study includes phytochemical screening of primary and secondary metabolites, physico-chemical analysis, pharmacological studies, elemental analysis, and flouroscent studies. The comparative priliminary studies of Butea monosperma and Nigella sativ...
3088
1342
SIMULTANEOUS EXPOSURE TO BENZENE AND ALCOHOL IN PETROL PUMP OPERATORS
A study on biological monitoring of simultaneous exposure to benzene and alcohol was made in petrol pump operators of Meerut city (India). In addition to alcohol, other confounding factors viz. cigarette smoke, food habit, age and work experience were also considered. Thirty two, 20-40 years old male workers were registered for this study. Respective urine samples collected after the workshift wer...
3377
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DRUG PRESCRIBING PATTERN AND COST ANALYSIS OF ANTIPSYCHOTICS AT A TERTIARY CARE HOSPITAL
Objective: Schizophrenia is a psychiatric disorders rapidly rising in India. There are numerous classes of antipsychotic agents available. It is important to find out which are the most frequently prescribed antipsychotics in population subsets of various regions of the country. Similarly, it is also important to do apharmacoeconomic evaluation of such treatment. Thus the primary objective of the ...
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A COMPARATIVE STUDY TO EVALUATE ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF COMMONLY USED PROTEOLYTIC ENZYMES AND THEIR COMBINATION WITH DICLOFENAC IN RATS
Introduction: Proteolytic enzymes like serratiopeptidase, trypsin and chymotrypsin are used for prolonged period for edema resolution in post-operative patients, arthritis, tooth extraction etc. either alone or with other anti-inflammatory agent. Various trials have supported and refused the role of enzymes as anti-inflammatory agents. No study was found for analgesic property of proteolytic enzym...
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PROTECTIVE EFFECT OF “RAPHANUS SATIVUS” EXTRACT AGAINST COPPER SULPHATE TOXICITY IN “CTENOPHARYNGODON IDELLA” FISH
The living organisms of the aquatic ecosystem have been directly affected by the accumulation of the heavy metals in the aquatic environment 1. Fishes are very good biosensors of aquatic contaminants and as bio-indicator species respond with great sensitivity to changes in the aquatic environment. Copper will accumulate in many different organs in fish and mollusks. In the present study the acute ...
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EVALUATION OF ANTI- HYPERGLYCAEMIC ACTIVITY OF MAYTENUS EMARGINATUS WILLD LEAVES EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETES IN WISTAR RATS
Maytenus emarginatus Willd. Celeastraceae, popularly known as “Kankeri or kankero”, is a Thorny staff evergreen tree that is rich in various chemical constituents that determine the medicinal potential of this species. Diabetes mellitus is a disease that is affecting major population of the world. This study aimed to evaluate the antihyperglycaemic activity of the hydroalcoholic extract of the...
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PHYTOCHEMICAL AND BIOCHEMICAL STUDIES OF JASMINUM OFFICINALE LEAVES
Medicinal Plants are endowed with phytochemicals that are vital to counter various metabolic disorders like Oxidative damage in cells causing various degenerative diseases. Hence, the present study deals with the assessment of antioxidant activity and phytochemical screening of the aqueous extract of Jasminum officinale leaves. Antioxidant potential was evaluated in vitro using free radical scaven...
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1837
PURIFICATION AND CHARACTERIZATION OF ALKALINE PHOSPHATASE FROM A HALOTOLERANT FACULTATIVE ALKALIPHILE BACILLUS FLEXUS FPB17
The extracellular alkaline phosphatase from halotolerant facultative alkaliphile Bacillus flexus FPB17 was purified through precipitation / dialysis / chromatography and resulted in 28 fold of purification. The molecular weight of this enzyme through SDS-PAGE gel is 63 ± 2 kDa. Optimum conditions for purified ALP activity were pH 9.0 and 35°C. The enzyme proved to be thermolabile and gets comple...
4649
1601
ASSESSMENT OF VITAMIN D ON METABOLIC DISORDERS IN ARTHRITIC PREDIABETIC PATIENTS- A PHARMACOLOGICAL APPROACH
We planned to clarify the association between the Vitamin D supplementation and predisposition of metabolic syndrome including obesity, diabetes mellitus, hypertension and dyslipidemia in arthritic patient with pre diabetic condition and to assess prediabetes interfere in the disease progression. Retrospective observational study was conducted on 236 patients. Of these, Arthritis patients with no ...
2911
1170
ELECTROCHEMICAL BEHAVIOR OF MANIDIPINE AND ITS VOLTAMMETRIC DETERMINATION IN PHARMACEUTICAL FORMULATIONS
The electrochemical behavior of Manidipine is studied by employing cyclic voltammetry (CV) and Differential Pulse Polaro graphy (DPP) in universal buffers of PH ranging from 2.0 to 12.0. The kinetic parameters, such as transfer co-efficient, diffusion co-efficient, and heterogeneous forward rate constant values are evaluated by employing these techniques. Differential Pulse Polarography is emp...
2899
1216
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-(2′-HYDROXY-3′-NITRO-5′-METHYLPHENYL)-5-(ARYL/HETERYL) PYRAZOLES
Heterocyclic compounds are well known for their different biological activities like anti-inflammatory, antibacterial, antifungal, anticancer, insecticidal, pecticidal, antibiotic, etc. the versatile applications of oxygen, nitrogen and sulphur containing heterocyclic compounds have made this area of extensive research. The present study deals with the synthesis of some new 3-(2'-hydroxy-3'-nitro-...
2951
1189
HEXAVALENT CHROMIUM INDUCED ALTERATIONS IN THE NUCLEIC ACIDS AND PROTEIN METABOLISM IN THE LIVER OF THE FINGERLINGS OF FRESHWATER SILUROID, MYSTUS (M.) VITTATUS (BL.)
Fingerlings of Mystus (M.) vittatus (Bl.) a freshwater siluroid when subjected to a sublethal concentration of 2.4 mg/l hexavalent chromium for 20 days elicited significantly decreased RNA and protein in the liver. However, 10 days of exposure under the same stress produced no significantly alteration neither in the protein content nor in the nucleic acids (DNA, RNA) content of the liver. Results ...
2650
1057
EFFECT OF VITAMIN E ON BLOOD GLUCOSE LEVEL IN RABBITS AND ITS POSSIBLE INTERACTION WITH COMMONLY USED ANTI DIABETIC AGENTS
Effect of Vit. E on blood glucose and its possible interactions with oral antidiabetic agents (i.e. glimepiride, gliclazide and metformin) in rabbits have been reported in the present study. The study was performed on albino rabbits in which hyperglycemia was induced by giving glucose. We observed that Vit.E significantly lowered the blood glucose level but on co-administration with oral antidiabe...
3375
1050
PHYSIOCHEMICAL MICROBIAL AND PHARMACOLOGICAL STUDIES OF Zn (II) – 6- THIGUANINE DRUG COMPLEX
A new complex has been synthesized of Zn (II) complex with 6-thioguanine and physicochemical characterized by amperometry, polarography elemental analysis, UV and IR spectroscopy. After Synthesis of metal complex, it was evaluated it for antibacterial activities against various pathogenic microorganisms such as; Streptococcus aureus, Proteus. M., klebsiella pneumonia and Asperginus Niger, Nigrospo...
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1017
EFFECT OF ORAL ADMINISTRATION OF VITAMIN A ON BLOOD GLUCOSE LEVEL IN RABBITS AND ITS POSSIBLE INTERACTIONS WITH COMMONLY USED ORAL ANTIDIABETIC AGENTS
In diabetes mellitus antioxidant vitamins are commonly employed to prevent or mitigate the long term complications of the disorder. Diabetic retinopathy, nephropathy, coronary and cerebral vascular insufficiency are examples of such complications. They are more common in Type 2 diabetes mellitus. The present study was conducted to observe the effect of Vit A on blood glucose level and its possible...
2652
969
STUDY OF EFFECT OF ERYTHROMYCIN BASE ON GASTROINTESTINAL SMOOTH MUSCLES IN LABORATORY ANIMALS IN-VITRO
Background - Drugs affecting gastrointestinal motility find place in the treatment of gastrointestinal motility disorders. Objective: To evaluate the effect of erythromycin base on the isolated tissue of rabbit jejunum, guinea pig ileum & rat colon in vitro and also to see whether it alters the contractile responses induced by acetylcholine. Materials and Methods: a) Rabbit jejunum experiment:...
3155
1389
NATURE’S RESPONSE TO INFLUENZA: A HIGH THROUGHPUT SCREENING STRATEGY OF AYURVEDIC MEDICINAL PHYTOCHEMICALS
Inhibition of viral coating protein is an established therapeutic strategy for the treatment of many influenza treatment regimes. Although resistance to such inhibitors is common phenomena in different influenza treatment, such resistance can be averted by targeting coating proteins with phytochemicals. Swine Flu neuraminidase protein (H1N1) has been currently focused target for influenza inhibito...
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