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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 13 (2022) - Issue 11, November

Review Articles

 
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1.

MESENCHYMAL STEM CELLS (MSCS) AS POTENTIAL SOURCES OF TREATMENT OF NEURODEGENERATION DISEASE: A STRATEGIC REVIEW

Mesenchymal Stem Cells are multipotent adult stem cells that are found in tissues of the body, including umbilical lines, bone marrow, fat cells, etc. Mesenchymal stem cells incline to self–restore tissues, such as bone, fat cells, connective tissues, and microglia cells, which are obtained from the mesoderm layer and act as macrophages in the central nervous system. So, MSCs can be used to prom...

Shreya Shreshtha, Rahul Verma, Shubham, T. S. Gopenath and Kanthesh M. Basalingappa *

Division of Molecular Biology, Department of Biotechnology and Bioinformatics, Faculty of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4254-68

4254-4268

338

401

2.

THERAPEUTIC POTENTIAL OF CULINARY SPICES

Spices are herbs used as flavoring, aromatic, and coloring agents. The culture of various countries even involves the incorporation of spices daily, not just for their culinary potential but also for the health benefits they provide. Many age-old scriptures suggest incorporating the Indian System of Spices in everyday meals to counter many diseases and keep them at bay. The fact that dietary facto...

Akanksha Singh, Shikha Saxena, Swati Madaan, Reecha Madaan, Avneet Kaur Lamba and Ramanpreet Walia *

Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4269-96

4269-4296

265

234

3.

A NARRATIVE REVIEW OF THE ANTI-SARS-COV2 MONOCLONAL ANTIBODIES COCKTAIL – CASIRIVIMAB PLUS IMDEVIMAB FOR SARS-COV2 INFECTION

Numerous therapeutic and prophylactic interventions are tried being developed and tried for COVID-19, from repurposed drugs, antivirals to immunotherapy including convalescent serum, vaccines and monoclonal antibodies to reduce the global burden of the disease. Vaccine-derived immunity develops over time and remains as the primary option for prophylaxis. Administration of neutralizing mAbs is an i...

Maria Jose, Sasmi M. B and Praveenlal Kuttichira

Department of Pharmacology, Government Medical College, Manjeri, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4297-04

4297-4304

232

168

4.

GLIMPSE OF PHARMACEUTICAL COATING PROCESSES

Manuscript aims to furnish glimpse on coating processes (CoPr). The coating is the process of applying coating materials (CoMa) onto the substrate surface (S-S). With time and space dimension of CoPr, that upraised as sugar-coating (S-C) expanded to film-coating (F-C) and specialized one. Lengthy and wearisome processing and skilled operators issues inherited to S-C spring-up F-C and its improveme...

Mahammed Athar Alli Saikh

Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore, Koraput, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4305-20

4305-4320

232

200

5.

RECENT ADVANCES AND DIFFERENT APPLICATIONS OF PETASIS-BORON MANNICH REACTION

The Petasis boron-Mannich process, also referred to as the Petasis reaction, combines boronic acid, an amine, and a carbonyl derivative in a multi component coupling process. Recent progress on petasis reaction is discussed in this review. The various merits of petasis reaction over the other multi-component coupling reactions are explain here. Noncanonical substrates are used to explore the expan...

K. Daware *, S. Jadhav, K. Varma, K. Valve, S. Shinde, V. Pardesi, A. Shelke and T. Lokhande

Department of Pharmaceutical Chemistry, Mahatma Gandhi Vidyamandir’s Pharmacy College, Panchavati, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4321-35

4321-4335

198

152

6.

A COMPREHENSIVE REVIEW OF RECENT AND FUTURE PROSPECTS OF NANOGELS

A hydrogel with strongly cross-linked hydrophilic polymer chains makes up the majority of nanogels, which are essentially nanoparticles. Several hydrophilic functional groups in hydrophilic polymers enable nanogels to absorb large amounts of water. Incredibly stable, adaptable, and responsive to sensory influences, nanogels have the potential to be a safe and effective medication delivery vehicle ...

Vinod Kumar, Prashant Kumar and Saurabh Sharma *

School of Pharmaceutical Sciences, CT University, Ferozepur Road, Sidhwan Khurd, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4336-48

4336-4348

101

98

7.

NATURAL PLANT EXTRACTS USED IN THE MANAGEMENT OF STREPTOZOTOCIN (STZ) INDUCED DIABETES MELLITUS IN RODENTS

Diabetes mellitus is an associated symptom of untreated high blood sugar, and it's linked to long-term organ damage, dysfunction, and failure in adults. The ongoing increased scale of Diabetes mellitus will severely impact the long-term health of the global population and the global economy unless appropriate prevention and management strategies are established. Plants were studied using streptozo...

Saba Fatma *, Monika Singh, Shalini Sharma and Aamna Tabassum

Department of Pharmacology, Sunder Deep Pharmacy College, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4349-62

4349-4362

97

98

8.

BAEL (AEGLE MARMELOS) AN ASTONISHING HERB OF INDIA: A REVIEW

Aegle marmelos (L.) is an important plant with various medicinal values. It is commonly known as Bael (or Bel), belonging to the family Rutaceae. Bilwa is used to cure a variety of diseases. All the parts of this plant-like fruit, leaves, bark, stem and roots are used in different diseases, a variety of alkaloids are found in it. Compounds purified from the fruit have been proven to have biologica...

Deepak Garg, Pragi *, Amit Sharma and Varun Kumar

Department of Pharmacy, Jagannath University, Bahadurgarh, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4363-72

4363-4372

97

90

9.

INTRICACIES IN TRISOMY 21; ROLE OF CERTAIN POLYPHENOLS IN COGNITIVE DYSFUNCTION ALLIED WITH NEURODEGENERATION

One of the most prominent issues with Down Syndrome (DS) individuals is the cognitive deficits that come with early-onset Alzheimer’s disease (AD). Numerous mechanisms are accountable for neurodegeneration and declined cognition, including impairment in neurogenesis leading to hypocellularity in the cortex, cerebellum and hippocampus, altered dendritic morphology, and altered synapses plasticity...

Gaurav Kumarbhargav *, Pallab Kalita, Rofiqul Islam, Jayita Das, Tina Bania and Pyrkhatlang Myrboh

School of Pharmaceutical Sciences, University of Science and Technology Aridua, Meghalaya, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4373-77

4373-4377

87

71

10.

A REVIEW OF CLINICAL STUDIES IN TUBERCULOSIS REGISTERED IN THE CLINICAL TRIALS REGISTRY OF INDIA

Background: Currently, 23 drugs for treating drug-susceptible TB, MDR-TB, or latent TB infection are in Phase I, II, or III trials. Bedaquiline, Delamanid and Pretomanid are new approved drugs. Still, TB is more prevalent in many countries. So, ideally, the countries facing this problem should do extensive research. Aim: The aim of our study is to find the number of studies, their design, sponsors...

M. Prajapati * and Y. Shetty

Department of Pharmacology and Therapeutics, Seth G. S. Medical College & K. E. M. Hospital, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4378-84

4378-4384

89

82

11.

NANOGELS: AN OVERVIEW OF PROPERTIES, CLASSIFICATIONS, DRUG TARGETING METHODS, EVALUATION PARAMETERS AND APPLICATIONS

Nanogels (NGs) are advanced and innovative drug delivery systems that play an important role in remarking many issues that are associated with recent and trendy courses of treatment, such as non-specific effects and low stability. NGs could be well-defined as extremely cross-linked hydrogels (nano-sized) ranging from 20-200 nm. NGs are vigorous nanoparticles (NPs) used to deliver active ...

Arti * and KM. Archna

Research and Development Officer in Orikam Healthcare India Pvt. Ltd, Gurugram, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4385-00

4385-4400

101

104

12.

RECENT RECOMMENDATIONS IN THERAPEUTIC APPROACHES FOR DIABETES AND ITS COMORBIDITIES

Diabetes Mellitus (DM) is a persistent metabolic cluster of diseases that involves erroneously excessive blood glucose levels. The polygenic disorder cluster of diseases includes Type I, Type II, Physiological state polygenic disorder (Gestational diabetes), Infant polygenic disorder (Neonatal diabetes), Maturity Onset Diabetes of the Young (MODY), and secondary causes because of endocrinopathies,...

Gulnaazbanu. M. Shaikh * and Jagdish Kakadiya

Department of Pharmacology, Parul Institute of Pharmacy & Research, Limda, Waghodia, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4401-09

4401-4409

88

95

13.

REVIEW STUDIES ON THE FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF SOME ANTINEOPLASTIC DRUGS

Cancer refers to a group of diseases characterized by abnormal, unchecked cell growth that spreads to other body parts. Breast, liver, colorectal, kidney, stomach, lungs, and cervical cancer are the most common tumours, with skin cancer (excluding melanoma) being the least common (contributing up to 40 percent of the cases). Surgery, chemotherapy, and other traditional medical methods have several...

Chandra Shekhar Sharma *, Subas Chandra Dinda and Anurag Verma

Department of Pharmaceutics, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4410-46

4410-4446

102

96

14.

A COMPREHENSIVE REVIEW ON PSIDIUM GUAJAVA LINN: AS AN HERBAL REMEDY

Psidium guajava Linn is an herbal remedy used in Ayurveda as a traditional system of medicine in ethnomedicine. It is a tropical evergreen plant that grows in tropical and subtropical climates. It has a wide variety of nutritional components. The whole plant and various parts of the plants possess different types of therapeutic activity, such as Tannin, phenols, triterpenes, flavonoids, essential ...

Saheli Chakraborty, Rajesh Ghosh, Soumyadip Ghosh * and Debgopal Ganguly

Department of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and AHS, Uluberia, Howrah, Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4447-54

4447-4454

118

104

Research Articles

 
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15.

MIZORIBONE IS EFFECTIVE AGAINST LECLERCIA ADECARBOXYLATA INFECTION

Leclercia adecarboxylata is a gram-negative bacillus. L. adecarboxylata has been isolated from various environments, such as food and water, and clinical specimens from patients with various diseases and ailments, such as pyelonephritis and sepsis. Although L. adecarboxylata infections are generally treated with β-lactam antibiotics, the emergence of multidrug-resistant strains reported in recent...

K. Odanaka

Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomitamachi-aza, Koriyama, Fukushima, Japan.

DOI: 10.13040/IJPSR.0975-8232.13(11).4455-58

4455-4458

210

158

16.

EVALUATION OF HEPATOPROTECTIVE POTENTIAL OF ALSTONIA SCHOLARIS STEM BARK AGAINST CCL4 INDUCED HEPATOTOXICITY – AN IN-VIVO SCREENING

The hepatoprotective potential of ethanolic extract of stem bark of Alstonia scholaris belonging to the family Apocynaceae and commonly known as Devil’s tree or Saptaparni was assessed against carbon tetrachloride-induced hepatotoxicity in Wistar rats. It is an evergreen tropical tree native to the Indian sub-continent and Southeast Asia and contains various phytoconstituents like alkaloids, tri...

Jaspreet Kaur Sodhi *, Birendra Shrivastava and Hardarshn Singh Lamba

H. R. Institute of Pharmacy, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4459-65

4459-4465

242

172

17.

ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF DIFFERENT EXTRACTS OF THREE VARIETIES OF CARISSA CARANDAS FRUITS AND INHIBITION OF DIGESTIVE ENZYMES RELEVANT TO TYPE 2 DIABETES MELLITUS

Carissa carandas is a well-known traditional medicinal plant with a wide range of pharmaceutical properties. In the present studies, three Carissa carandas fruit extract varieties were investigated for the activities relevant to type 2 diabetes mellitus, including inhibition of α-amylase and α-glucosidase. Different solvent extracts such as methanol, ethanol, and aqueous extracts of Carissa cara...

D. Sudha, R. Malarkodi, A. Gokulakrishnan * and A. R. Liyakath Ali

Department of Biochemistry, Islamiah College (Autonomous), Vaniyambadi, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4466-75

4466-4475

209

153

18.

PAPAIN LIKE PROTEASE: A POTENTIAL TARGET FOR MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-COV): THE BATTLE CONTINUES

Middle-East Respiratory Syndrome coronavirus (MERS-CoV) can trigger severe acute pneumonia, renal, digestive failure and even death. Coronaviruses express papain-like proteases (PLpro), multipurpose enzymes which had protease activity and can lacerate nonstructural proteins to manipulate the viral polyprotein responsible for replication. They also have deubiquitinating function, which can modify t...

Neeldeep Ganguly, Swagata Roy and Tamalika Chakraborty *

Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Road, Sodepur Panihati, Kolkata, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4476-84

4476-4484

200

137

19.

ROLE OF CYANOBACTERIA IN HEAVY-METAL REMOVAL FROM WATER AND WASTEWATER BY BIOSORPTION PROCESS

Heavy metal toxicity has been a subject of concern for the past few decades. Due to the emerging awareness about the detrimental health hazards and adverse effects across all the levels of any ecosystem, the removal of heavy metals (HM) from contaminated water systems and soil has gained the profound attention of the scientific community for the last couple of decades. Living and dead cells of bio...

Arghya Nath, Dooja Singh, Somashree Das, Parna Dey and Atreyi Ghosh *

Department of Microbiology and Biotechnology, Sister Nivedita University, West Bengal, Kolkata, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4485-06

4485-4506

239

149

20.

ANTI-DIABETIC AND ANTI-HYPERTENSIVE ACTIVITIES OF CITRUS FRUIT PEELS

Orange (Citrus sinensis), Kinnow (Citrus reticuleta), and Mosambi (Citrus limetta) methanolic, the aqueous extract showed the inhibitory activity on α-amylase and α-glucosidase assay where methanolic, acetone and aqueous extract of these fruit peels exhibited the anti-hypertensive activities. The results showed that the methanol and aqueous extract of Orange, Kinnow, and Mosambi peels inhibited ...

Swati Gupta * and Shanthy Sundaram

Centre of Biotechnology, Nehru Science Centre, University of Allahabad, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4507-12

4507-4512

85

83

21.

EVALUATION OF THE PHARMACOPHORIC ACTIVITY OF DIFFERENT COMPOUNDS OBTAINED BY GC-MS IN AQUEOUS EXTRACT OF LAWSONIA ALBA

Most of the medications currently in use are largely derived from the traditional plants and their products. Lawsonia alba, often known as henna, has a wide range of medicinal uses, from minor infections to cancer and is also used as a hair dye. All of these pharmacological actions and therapeutic uses are because of the presence of numerous secondary metabolites. These were isolated using the GC-...

Simhadri V. S. D. N. A. Nagesh *, K. K. Bairagi and Sudhir Modala

Department of Pharmacology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4513-27

4513-4527

70

75

22.

EVALUATION OF IN-VIVO ANTI-AGGRESSIVE ACTIVITY OF EXTRACTS OF ALSTONIA SCHOLARIS LEAVES AGAINST ANIMAL MODELS OF AGGRESSION

Aggressive behavior is an important prerequisite for acquiring and maintaining feeding resources, territory and mating partners and, therefore, for the survival of an individual and the species. However, dysregulation of aggression among conspecifics can lead to severe injury and death. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydr...

Swati Trivedi, Rajneesh Kumar Gupta * and Akriti Pal

Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4528-35

4528-4535

87

70

23.

VALIDATED METHOD FOR THE SIMULTANEOUS DETERMINATION OF EMTRICITABINE, BICTEGRAVIR AND TENOFOVIR ALAFENAMIDE IN PHARMACEUTICAL DOSAGE FORM USING UPLC

The proposed study aimed to develop and validate a method for the simultaneous determination of emtricitabine, bictegravir, and tenofovir alafenamide in pharmaceutical dosage form using ultra-ultra dosage performance liquid chromatography (UPLC). The drugs were separated using HSS C18 (100 x 1.8mm, 1.7m) column with a mobile phase composition consisting of 0.1% orthophosphoric acid (pH 2.2) and ac...

Vamsi Dadi * and G. Sowjanya

Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4536-43

4536-4543

83

80

24.

IN-SILICO VALIDATION OF CLOVE AS A POTENTIAL NUTRACEUTICAL AGAINST SARS-COV-2

The pandemic COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has killed millions of human beings throughout the world and attaining natural immunity against this virus is the best remedy. Consumption of nutraceuticals having antiviral and immune-boosting ingredients is the natural way to fight against it. The main objective of the present study was to evaluate the a...

J. Keerthi Sugathan, S. Sreekumar * and C. K. Biju

Biotechnology and Bioinformatics Division, Saraswathy Thangavelu Extension Centre, KSCSTE-Jawaharlal Nehru Tropical Botanic Garden and Research Institute, A Research Centre of Kerala University, Thiruvananthapura, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4544-53

4544-4553

83

68

25.

FORMULATION AND IN-VITRO CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLET OF DEXIBUPROFEN

Dexibuprofen is a Non-Steroidal Anti-Inflammatory Drug. It indicated short-term management of mild to moderately severe acute pain, dental pain, dysmenorrhoea, muscular pain and osteoarthritis. In the prevailing work, studies have been carried out on the preparation and in-vitro characterization of matrix tablets of dexibuprofen using different polymers like hydrophilic and hydrophobic. Different ...

Abul Ashad Nistahar and Zubaidur Rahman *

NEF College of Pharmaceutical Education and Research, Nagaon, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4554-59

4554-4559

83

81

26.

HOMOLOGY MODELLING AND ANALYSIS OF PROTEIN DRUG TARGETS FOR ERYSIPELOTHRIX RHUSIOPATHIAE A BACTERIAL PATHOGEN CAUSING SWINE ERYSIPELAS

Aim of this study was to generate 3D models of protein drug targets in Erysipelothrix rhusiopathiae by homology modelling. E. rhusiopathiae causes swine erysipelas disease that has great economic impact on the pork industry. Bioinformatic databases such as Uniprot KB, Drug Bank, PMDB and online tools such as BLASTp, SWISS Model and Ramachandran plot analysis and software such as Autodock4 and Pymo...

Annapoorna Harikumar, C. Khushi, S. Manaswini, Medha M. Savkar, K. Rakshith Srivatsa, Sanmitha Narayan and Lokesh Ravi *

Department of Botany, St. Joseph’s College (Autonomous), Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13 (11). 4560-67

4560-4567

72

66

27.

FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF BISOPROLOL FUMARATE

The main objective of this research work was to formulate and evaluate an Orodispersible tablet of Bisoprolol Fumarate for the treatment of hypertension and coronary artery disease. Formulation was designed using systat software version 13.2. 32 full factorial design was applied, in which two variables were varied at three levels. The tablets of Bisoprolol Fumarate were developed by direct compres...

V. Nagathan *, V. Kadagi, F. Dsankoppa, S. Hiremath and R. Sagare

Department of Pharmaceutics, KLE College of Pharmacy, Vidyanagar, Hubballi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4568-76

4568-4576

106

84

28.

PREDICTION OF POTENTIAL DIETARY COMPOUNDS AGAINST HER2: AN IN-SILICO ASSESSMENT

Presently, in-silico approaches have been introduced as alternative methods for the process of drug invention. The current investigation aimed to explore expectations and the examination of the chemotherapeutic potential dietary phytochemicals as effective anti-cancer agents against HER2. This receptor plays a pivotal role in the development of breast cancer. Here, protein-ligand virtual screening...

K. S. N. M. Megana and Y. Suneetha *

Department of Zoology, Sri Venkateshwara University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4577-85

4577-4585

79

61

29.

ETHNOBOTANICAL STUDY OF MEDICINAL PLANTS USED BY THE DIFFERENT TRIBAL COMMUNITIES IN NILAKH- SRIPANI AREA OF DHEMAJI DISTRICT, ASSAM

Due to plentiful wild plant diversity, poor road conditions to connect modern medical facilities, and age-old folk knowledge on medicinal plants, the tribal communities of Dhemaji District, Assam, India, still practice traditional plant-based therapy in the management of primary healthcare. The present investigation aims to represent the ethnobotanical knowledge of different ethnic community peopl...

Pranab Borah and Mousmi Saikia *

Department of Herbal Science & Technology, A. D. P. College, Nagaon, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4586-07

4586-4607

83

74

30.

CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SEED EXTRACT OF N. NUCIFERA

N. nucifera, often recognized as lotus, is an aquatic plant. Extracts of various solvents have shown therapeutic potential against many diseases. This research focused on screening preliminary qualitative phytochemicals and investigating the seed's antioxidant activity. Primary and secondary metabolites were discovered in a hydroethanolic fraction of different extracts of lotus seeds. The extract...

Saya Tyagi, Anuradha Shukla, Pankaj Jain and Rashmi Tripathi *

Department of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4608-19

4608-4619

88

88

31.

INVESTIGATION OF ANTI-SWARMING, ANTI-BIOFILM AND ANTI-QUORUM SENSING POTENTIAL OF SOME ORGANIC TEA OF DIFFERENT BRANDS FROM INDIA

The emergency to find a solution to multidrug resistance of bacteria due to the abuse of antibiotics leads to the search for new antibacterial pathways. Quorum sensing (QS), or bacterial cell to cell communication, is a cell-density-dependent bacterial response. It is mediated by hormone-like compounds called autoinducers (AIs). QS-dependent regulation of gene expression controls various phenotype...

P. V. Hirapure *, S. A. Paranjape, T. V. Bind, K. K. Bawankar and V. J. Upadhye

Department of Biochemistry and Biotechnology, Dr. Ambedkar College Deekshabhoomi, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4620-27

4620-4627

80

68

32.

PREDICTION OF POTENTIAL INHIBITORS SIMILAR TO REMDESIVIR (GS-5734) AGAINST 7BTF SARS COV 2 RNA DEPENDENT RNA POLYMERASE – AN IN-SILICO APPROACH

The novel Corona Virus Disease - 19 (COVID-19) is a Contagious disease spreading among Animals and Humans, a Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS CoV2). The First case was identified in Wuhan, China as the disease has unfolded worldwide to the continuing pandemic. It created more infected cases and deaths worldwide, creating an urge for newer drugs of manipulate the Ongoing Pandem...

K. Akila *, B. Pooja and R. Sharmila

Department of Biotechnology and Bioinformatics, Bishop Heber College (Autonomous), Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4628-35

4628-4635

70

67

33.

ADD-ON EFFECT OF SELECTED AYURVEDIC TREATMENT PROTOCOL IN FOCAL SEIZURES EVOLVING TO GENERALIZED SEIZURES – A NON-RANDOMIZED CONTROLLED TRIAL

Epilepsy is a chronic non-communicable disease that affects 50 million people worldwide. AEDs play a vital role in controlling seizures but are not a permanent solution. For a large percentage of Persons with Epilepsy, seizures happen even with the intake of AEDs. Apasmāra is more or less compared to epilepsy. The majority of studies conducted on Apasmāra were śamana therapies and suggested śo...

Vidhya M. Sanker * and M, Jithesh

ManoVigyan Avum Manasroga, VPSV Ayurveda College, Kottakkal, Kerala India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4636-40

4636-4640

87

73

34.

IDENTIFICATION AND ISOLATION OF BIOACTIVE COMPONENTS USING GC-MS, UV VISIBLE, FTIR, HPLC, HPTLC AND ANTIOXIDANT ACTIVITY PRESENT IN ETHANOLIC EXTRACT OF INDIAN SPICES MIXTURE

Introduction: The spices, despite their taste and flavor, have certain therapeutical uses from ancient days. For this research work, we have chosen some selected spices indefinitely amount. Materials and Methods: Phytochemical analysis, mineral estimation Characterisations such as GC-MS, UV Visible & FTIR spectroscopy, HPLC, HPTLC, and Antioxidant activity were carried out. Results & Discu...

B. Ramya *, V. Shanmuga Priya and S. Ranjani

PG Department of Biochemistry, Holy Cross College (Autonomous), Trichy, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4641-55

4641-4655

75

74

35.

ISOLATION AND CHARACTERIZATION OF LEAF SPOT PLANT PATHOGENS FROM SPINACIA OLERACEA

Spinacia oleracea L. (child spinach) is a generally new leaf vegetable in the Amaranthaceae family. The crop is high in human supplements and generally has significant degrees of bioactive mixtures like nutrients A also C and minerals. In the present study, the fungi and bacteria from the infected leaves of Spinacia oleracea are isolated and morphological identified. DNA isolation of the cultured ...

G. Rahini and V. Sumathi

Faculty of Science, Annamalai University, Chidambaram, Cuddalore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4656-60

4656-4660

85

67

36.

ACYCLOVIR LOADED GELATIN BIODEGRADABLE NANOPARTICLES: FORMULATION, OPTIMIZATION, CHARACTERIZATION, AND IN-VIVO EVALUATION

Acyclovir has a ratified antiretroviral effect for Herpes simplex virus type 1 (HSV-1), HSV-2, Varicella zoster virus (VZV), Herpesvirus simiae and to a minor extent, Epstein-Barr virus (EBV). The oral bioavailability of acyclovir is indigent, with only 15%–30% of the oral formulations' vitality absorbed. To baffle the issue of insignificant bioavailability, acyclovir was formulated into biodegr...

Ashish Kumar Varma * and Namita Arora

Faculty of Pharmacy, Lords University, Alwar, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4661-70

4661-4670

82

80

37.

PHARMACOGNOSTICAL STANDARDIZATION AND PRELIMINARY PHYTOCHEMICAL INVESTIGATIONS ON ANANAS COMOSUS (L.) MERR.

Pineapple or 'Ananas,' is a tropical fruit that belongs to the Bromeliaceae family. The stem and fruit of this plant are utilized in conventional and folk medicine for treating various illnesses. In addition to calcium, iron, potassium, pineapples are a rich source of vitamin C, B and A. This study involves determinations various standardization specifications for the plant Ananas comosus (L.) Me...

Virender Kumar, Vandana Garg * and Harish Dureja

Faculty of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4671-79

4671-4679

75

70

38.

DEVELOPMENT AND VALIDATION OF NOVEL RP-HPLC METHOD FOR THESIMULTANEOUS ESTIMATION OF EZETIMIBE AND BEMPEDOIC ACID IN A TABLETDOSAGE FORM

A simple, novel, precise, and cost-effective reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated to simultaneously estimate ezetimibe and bempedoic acid in the marketed tablet dosage form. The chromatographic separation was carried out on a Prontosil C18 (250 x 4.6 mm, 5 µm) column using a mobile phase of Acetonitrile: water (60:40 v/v). The flow rate...

Vandana Jain *, Daksha Rahamatkar and Shubham Nikam

Department of Quality Assurance, Oriental College of Pharmacy, Sanpada, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4680-85

4680-4685

117

112

39.

PREPARATION AND EVALUATION OF LIPID MICROSPHERE OF VERAPAMIL HYDRO-CHLORIDE

Microspheres drug delivery system have improved patient compliance, decreased toxicity, and increased efficacy. This work aimed to design a controlled-release drug-delivery system for lipid microspheres of Verapamil hydrochloride that would retain the drug in the stomach and continuously release the drug in a controlled manner up to a predetermined time. Lipid microspheres were prepared by using a...

Vikrant Nikam * and Sanjay Jain

Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4686-95

4686-4695

82

70

40.

PRODUCTION OF SINGLE-CELL PROTEIN FROM DARJEELING MANDARIN PEELS USING ASPERGILLUS NIGER AND ASPERGILLUS ORYZAE

Single Cell Protein (SCP) refers to the dead, dried cells of various microbes, including bacteria, yeast, algae, and fungi. This type of biomass can be obtained from economically cheap substrates like agro-wastes as a non-conventional proteintious source for human or animal feed. The bioconversion of Darjeeling mandarin peels into single-cell protein (SCP) was performed using Aspergillus niger and...

Debarati Roy and Jayati Bhowal *

School of Community Science and Technology, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4696-03

4696-4703

79

71

41.

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF SOLID DISPERSION OF QUERCITIN LOADED ORAL WAFERS

Quercetin (3, 3ʹ, 4ʹ, 5, 7-pentahydroxyl-flavone) is a flavonol, belonging to the class of plant secondary metabolites known as flavonoids. Quercetin and its derivatives have various beneficial effects against ailments like inflammation, oxidative stress, and cancer. The present research work aimed to prepare and characterize quercetin's solid dispersion (SD) to enhance solubility and thereby di...

Sanjay Srivastava and Akash Ved *

Goel Institute of Pharmaceutical Sciences, Near Indra Canal, Ayodhya (Faizabad) Road, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4704-11

4704-4711

80

74

42.

ESTIMATION OF ANTIARTHRITIC ACTIVITY OF A POLYHERBAL FORMULATION AGAINST ADJUVANT INDUCED ARTHRITIS IN RATS

Objective: Rheumatoid arthritis (RA) is a systemic disorder which involves the activation of immune system against the self-tissues. The main targets of this disease are the joints. Being systemic, the development of this disease involves different mechanisms, and thus, the exact cause of this disease remains unknown. Although different drugs have been developed, none has been found to be the cure...

T. J. Mohan Rao *, Margret Chandira and B. S. Venkateswarlu

Vinayaka Mission's Research Foundation - Deemed to be University (VMRFDU), Sankari Main Road, Ariyanur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4712-18

4712-4718

82

75

43.

PREPARATION AND EVALUATION OF EXTENDED-RELEASE MICROSPHERES OF QUETIAPINE FUMARATE

The objective of present study was to develop extended release microspheres of quetiapine fumarate using Eudragit RS 100 and Eudragit RL100 to reduce the dosing frequency. The quetiapine fumarate-loaded Eudragit microspheres were formulated by a solvent evaporation method. A 32 factorial design was employed to study the effect of concentration of sodium lauryl sulfate (SLS) and drug: polymer ratio...

Keyur S. Patel *, Sejal A. Madhak, Kunal N. Patel, Pragna R. Shelat and Deepa R. Patel

K. B. Raval College of Pharmacy, Shertha, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4719-26

4719-4726

82

83

44.

EVALUATION OF ANTIFUNGAL EFFECTS OF PLANT LEAVES EXTRACTS ON ISOLATED RHIZOPUS SPECIES FROM SOIL

Mucormycetes are a group of fungi causing a serious infection called mucormycosis. These fungi live throughout the environment, particularly in soil than in the air. This fungus is severely spread among people who have weakened immune systems; breathing in these spores can cause severe infection in the lungs or sinuses, which can spread easily to other parts of the body. In the present work, Rhizo...

N. Jayanthi

Department of Microbiology, Mannar Thirumalai Naicker College (Autonomous), Madurai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4727-33

4727-4733

79

68

45.

ASSESSING THE ANTIOXIDANT ACTIVITIES OF METHANOLIC EXTRACT OF SARACA ASOCA LEAVES AND BARK

Chronic diseases such as cardiovascular, cancer, and respiratory diseases are being increased. Reactive oxygen species, free radicals, and oxidative stress play a major role in aggravating these diseases. Plants and plant-derived compounds have shown a greater potential in combating the detrimental effects of free radicals and other toxic agents. The current research work has been done on the leaf...

Sonal Prasad, Tabish Qidwai * and Rohit Saluja

Faculty of Biotechnology, IBST, Shri Ramswaroop Memorial University, Lucknow, Barabanki- Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4734-41

4734-4741

92

78

46.

EFFECT OF EDUCATIONAL INTERVENTION ON MATERNAL KNOWLEDGE IN USE OF ANTIBIOTICS IN ACUTE RESPIRATORY INFECTIONS AMONG UNDER FIVE CHILDRENIN URBAN FIELD PRACTICE AREA OF MEDICAL COLLEGE BANGALORE

Background: Acute respiratory infections are the most important cause of mortality and morbidity among under-five children in developed and developing countries in the world. There is lack of awareness/ knowledge among parents regarding antibiotic use in children for minor respiratory ailments. Hence, the present study was undertaken. Methods and Methodology: After taking institutional ethical cle...

R. A. Prakruthi * and Chethana Ramegowda

Department of Community Medicine, SABVMCRI, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4742-44

4742-4744

70

68

47.

EXTENSIVE STUDY ON RETT SYNDROME: A CASE REPORT

Rett Syndrome is an extremely rare, post-natal, and serious genetic neurodevelopmental syndrome that occurs mostly in female children. It occurs due to the mutations in the MeCP2 gene of the X chromosome. Children with Rett syndrome are usually diagnosed within 24 months of their age. The mutation takes place on the S421 site of the MeCP2 gene. The information for coding MeCP2 protein is obtained ...

K. Shailaja *, M. Jasper Victoria Leelarani, S. N. John Felix, S. G. Santhoshkumar, P. Bala Krishnan and R. Vigneswaran

Department of Pharmacy Practice, C. L. Baid Metha College of Pharmacy, Thoraipakkam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4742-53

4745-4753

100

81

48.

METABOLIC DEFECTS OF THYROID HORMONE IN THE EMBRYONIC STAGE AUGMENT THE RISK OF DEVELOPING GESTATIONAL DIABETES MELLITUS AND OTHER SUSCEPTIBLE FACTORS

The objective of the study is to elucidate the association between thyroid dysfunction and increased risk of developing gestational diabetes mellitus (GDM) and assess the other risk factors for developing GDM. Retrospective observational research was carried out on 204 patients. Of these, pregnant women greater than 18 years were considered and recruited based on inclusion and exclusion criteria. ...

Nithya Darsini, TAnargha JayarajSrisha Kamaraju and G. Venkatesh *

Department of Pharmacology, KMCH College of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4754-62

4754-4762

76

78

49.

ANTIBACTERIAL ACTIVITY OF FIVE SPECIES OF MARINE MICROALGAE

Antibacterial activity of five marine microalgae Isochrysis galbana, Chaetoceros calcitrans, Tetraselmis suecica, Nannochloropsis oculata, Aphanocapsa sp. was studied from Visakhapatnam. The ethanolic extract of T. suecica, C. calcitrans, and N. oculata s howed inhibitory activity against V. harveyi and S. Aureus with inhibition zone between 11.5 and 20mm. The ethanolic extract of I. galbana showe...

G. Teja *, P. Yedukondala Rao, P. Janakiram, D. Sunil Kumar, V. A. Iswarya Deepti and P. Lakshmi Chaya

Department of Marine Living Resources, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4763-70

4763-4770

82

84

50.

ANTIDEPRESSANT ACTIVITY AND PHARMACOGNOSTIC EVALUATION OF ETHANOLIC EXTRACT OF STREBLUS ASPER LOUR

Streblus asper Lour is traditionally used for anti-diarrheal and anthelmintic activity. The present study aims to prove the antidepressant activity in a different extract of leaves of S. asper Lin animal models. The extracts of Sterblus asper L. significantly reduced the immobility time in the forced swimming test (FST), notable at 400 mg/kg when compared with the control group. The immobility tim...

Anil Kumar * and K. Saravanan

Department of Pharmacy, Bhagwant University, Sikar Rd, Ajmer, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4771-75

4771-4775

79

94

51.

FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF TOPICAL FILM-FORMING SOLUTION FOR TREATMENT OF DIABETIC FOOT ULCER

Diabetic foot ulcer is one of the leading causes of lower limb amputation and mortality in diabetic patients. Various factors contribute to the manifestation of chronic wounds in diabetic foot, but ischemia, infection, and elevated levels of matrix metalloproteases enzyme are the main factors. Matrix metalloproteases (MMPs) are elevated to as high as 60%. Thus, altering the wound-healing process. ...

Ravi Parashar, Kamta Prasad Namdeo and Manoj Kumar *

Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4776-81

4776-4781

110

87

52.

CELECOXIB, A SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, IS ANTICONVULSIVE IN MES INDUCED SEIZURES BUT PROCONVULSIVE IN PTZ INDUCED SEIZURES IN MICE: A POSSIBLE ROLE OF EXCITATORY AMINO ACID IN THIS DIFFERENTIAL EFFECT

Epilepsy is an achronic neurological disorder characterized by recurrent seizures. There is a positive feedback cycle between epileptogenesis and brain inflammation. It has been proved that COX 2 is expressed constitutively in certain parts of the CNS and is further induced as a result of seizurogenic activity. Of the various experimental models of epilepsy, one is the maximal electroshock (MES) m...

Raina Jain, Ajay Upadhyaya and Ashish Jain *

Department of Biochemistry, PCMS & RC, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4782-87

4782-4787

75

68

53.

IN-VIVO ANTI-CANCER AND HISTOPATHOLOGY STUDIES OF MORINGA OLEIFERA ON EHRLICH ASCITIC CARCINOMA CELLS

Moringa oleifera is an important food commodity with enormous attention as the 'natural nutrition of the tropics. Leaves of this plant are traditionally known for or reported to have various biological activities, including hypocholesterolemic agent, antidiabetic, gastric ulcers, antitumor and hypotensive agent. This study was designed to assess the toxicological and histopathological effects of e...

B. Ramanath * and K. Satheesh Naik

Department of Pharmacology, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4788-93

4788-4793

82

72