Volume 13 (2022) - Issue 11, November
MESENCHYMAL STEM CELLS (MSCS) AS POTENTIAL SOURCES OF TREATMENT OF NEURODEGENERATION DISEASE: A STRATEGIC REVIEW
Mesenchymal Stem Cells are multipotent adult stem cells that are found in tissues of the body, including umbilical lines, bone marrow, fat cells, etc. Mesenchymal stem cells incline to self–restore tissues, such as bone, fat cells, connective tissues, and microglia cells, which are obtained from the mesoderm layer and act as macrophages in the central nervous system. So, MSCs can be used to prom...
THERAPEUTIC POTENTIAL OF CULINARY SPICES
Spices are herbs used as flavoring, aromatic, and coloring agents. The culture of various countries even involves the incorporation of spices daily, not just for their culinary potential but also for the health benefits they provide. Many age-old scriptures suggest incorporating the Indian System of Spices in everyday meals to counter many diseases and keep them at bay. The fact that dietary facto...
A NARRATIVE REVIEW OF THE ANTI-SARS-COV2 MONOCLONAL ANTIBODIES COCKTAIL – CASIRIVIMAB PLUS IMDEVIMAB FOR SARS-COV2 INFECTION
Numerous therapeutic and prophylactic interventions are tried being developed and tried for COVID-19, from repurposed drugs, antivirals to immunotherapy including convalescent serum, vaccines and monoclonal antibodies to reduce the global burden of the disease. Vaccine-derived immunity develops over time and remains as the primary option for prophylaxis. Administration of neutralizing mAbs is an i...
GLIMPSE OF PHARMACEUTICAL COATING PROCESSES
Manuscript aims to furnish glimpse on coating processes (CoPr). The coating is the process of applying coating materials (CoMa) onto the substrate surface (S-S). With time and space dimension of CoPr, that upraised as sugar-coating (S-C) expanded to film-coating (F-C) and specialized one. Lengthy and wearisome processing and skilled operators issues inherited to S-C spring-up F-C and its improveme...
RECENT ADVANCES AND DIFFERENT APPLICATIONS OF PETASIS-BORON MANNICH REACTION
The Petasis boron-Mannich process, also referred to as the Petasis reaction, combines boronic acid, an amine, and a carbonyl derivative in a multi component coupling process. Recent progress on petasis reaction is discussed in this review. The various merits of petasis reaction over the other multi-component coupling reactions are explain here. Noncanonical substrates are used to explore the expan...
A COMPREHENSIVE REVIEW OF RECENT AND FUTURE PROSPECTS OF NANOGELS
A hydrogel with strongly cross-linked hydrophilic polymer chains makes up the majority of nanogels, which are essentially nanoparticles. Several hydrophilic functional groups in hydrophilic polymers enable nanogels to absorb large amounts of water. Incredibly stable, adaptable, and responsive to sensory influences, nanogels have the potential to be a safe and effective medication delivery vehicle ...
NATURAL PLANT EXTRACTS USED IN THE MANAGEMENT OF STREPTOZOTOCIN (STZ) INDUCED DIABETES MELLITUS IN RODENTS
Diabetes mellitus is an associated symptom of untreated high blood sugar, and it's linked to long-term organ damage, dysfunction, and failure in adults. The ongoing increased scale of Diabetes mellitus will severely impact the long-term health of the global population and the global economy unless appropriate prevention and management strategies are established. Plants were studied using streptozo...
BAEL (AEGLE MARMELOS) AN ASTONISHING HERB OF INDIA: A REVIEW
Aegle marmelos (L.) is an important plant with various medicinal values. It is commonly known as Bael (or Bel), belonging to the family Rutaceae. Bilwa is used to cure a variety of diseases. All the parts of this plant-like fruit, leaves, bark, stem and roots are used in different diseases, a variety of alkaloids are found in it. Compounds purified from the fruit have been proven to have biologica...
INTRICACIES IN TRISOMY 21; ROLE OF CERTAIN POLYPHENOLS IN COGNITIVE DYSFUNCTION ALLIED WITH NEURODEGENERATION
One of the most prominent issues with Down Syndrome (DS) individuals is the cognitive deficits that come with early-onset Alzheimer’s disease (AD). Numerous mechanisms are accountable for neurodegeneration and declined cognition, including impairment in neurogenesis leading to hypocellularity in the cortex, cerebellum and hippocampus, altered dendritic morphology, and altered synapses plasticity...
A REVIEW OF CLINICAL STUDIES IN TUBERCULOSIS REGISTERED IN THE CLINICAL TRIALS REGISTRY OF INDIA
Background: Currently, 23 drugs for treating drug-susceptible TB, MDR-TB, or latent TB infection are in Phase I, II, or III trials. Bedaquiline, Delamanid and Pretomanid are new approved drugs. Still, TB is more prevalent in many countries. So, ideally, the countries facing this problem should do extensive research. Aim: The aim of our study is to find the number of studies, their design, sponsors...
NANOGELS: AN OVERVIEW OF PROPERTIES, CLASSIFICATIONS, DRUG TARGETING METHODS, EVALUATION PARAMETERS AND APPLICATIONS
Nanogels (NGs) are advanced and innovative drug delivery systems that play an important role in remarking many issues that are associated with recent and trendy courses of treatment, such as non-specific effects and low stability. NGs could be well-defined as extremely cross-linked hydrogels (nano-sized) ranging from 20-200 nm. NGs are vigorous nanoparticles (NPs) used to deliver active ...
RECENT RECOMMENDATIONS IN THERAPEUTIC APPROACHES FOR DIABETES AND ITS COMORBIDITIES
Diabetes Mellitus (DM) is a persistent metabolic cluster of diseases that involves erroneously excessive blood glucose levels. The polygenic disorder cluster of diseases includes Type I, Type II, Physiological state polygenic disorder (Gestational diabetes), Infant polygenic disorder (Neonatal diabetes), Maturity Onset Diabetes of the Young (MODY), and secondary causes because of endocrinopathies,...
REVIEW STUDIES ON THE FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF SOME ANTINEOPLASTIC DRUGS
Cancer refers to a group of diseases characterized by abnormal, unchecked cell growth that spreads to other body parts. Breast, liver, colorectal, kidney, stomach, lungs, and cervical cancer are the most common tumours, with skin cancer (excluding melanoma) being the least common (contributing up to 40 percent of the cases). Surgery, chemotherapy, and other traditional medical methods have several...
A COMPREHENSIVE REVIEW ON PSIDIUM GUAJAVA LINN: AS AN HERBAL REMEDY
Psidium guajava Linn is an herbal remedy used in Ayurveda as a traditional system of medicine in ethnomedicine. It is a tropical evergreen plant that grows in tropical and subtropical climates. It has a wide variety of nutritional components. The whole plant and various parts of the plants possess different types of therapeutic activity, such as Tannin, phenols, triterpenes, flavonoids, essential ...
MIZORIBONE IS EFFECTIVE AGAINST LECLERCIA ADECARBOXYLATA INFECTION
Leclercia adecarboxylata is a gram-negative bacillus. L. adecarboxylata has been isolated from various environments, such as food and water, and clinical specimens from patients with various diseases and ailments, such as pyelonephritis and sepsis. Although L. adecarboxylata infections are generally treated with β-lactam antibiotics, the emergence of multidrug-resistant strains reported in recent...
EVALUATION OF HEPATOPROTECTIVE POTENTIAL OF ALSTONIA SCHOLARIS STEM BARK AGAINST CCL4 INDUCED HEPATOTOXICITY – AN IN-VIVO SCREENING
The hepatoprotective potential of ethanolic extract of stem bark of Alstonia scholaris belonging to the family Apocynaceae and commonly known as Devil’s tree or Saptaparni was assessed against carbon tetrachloride-induced hepatotoxicity in Wistar rats. It is an evergreen tropical tree native to the Indian sub-continent and Southeast Asia and contains various phytoconstituents like alkaloids, tri...
ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF DIFFERENT EXTRACTS OF THREE VARIETIES OF CARISSA CARANDAS FRUITS AND INHIBITION OF DIGESTIVE ENZYMES RELEVANT TO TYPE 2 DIABETES MELLITUS
Carissa carandas is a well-known traditional medicinal plant with a wide range of pharmaceutical properties. In the present studies, three Carissa carandas fruit extract varieties were investigated for the activities relevant to type 2 diabetes mellitus, including inhibition of α-amylase and α-glucosidase. Different solvent extracts such as methanol, ethanol, and aqueous extracts of Carissa cara...
PAPAIN LIKE PROTEASE: A POTENTIAL TARGET FOR MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-COV): THE BATTLE CONTINUES
Middle-East Respiratory Syndrome coronavirus (MERS-CoV) can trigger severe acute pneumonia, renal, digestive failure and even death. Coronaviruses express papain-like proteases (PLpro), multipurpose enzymes which had protease activity and can lacerate nonstructural proteins to manipulate the viral polyprotein responsible for replication. They also have deubiquitinating function, which can modify t...
ROLE OF CYANOBACTERIA IN HEAVY-METAL REMOVAL FROM WATER AND WASTEWATER BY BIOSORPTION PROCESS
Heavy metal toxicity has been a subject of concern for the past few decades. Due to the emerging awareness about the detrimental health hazards and adverse effects across all the levels of any ecosystem, the removal of heavy metals (HM) from contaminated water systems and soil has gained the profound attention of the scientific community for the last couple of decades. Living and dead cells of bio...
ANTI-DIABETIC AND ANTI-HYPERTENSIVE ACTIVITIES OF CITRUS FRUIT PEELS
Orange (Citrus sinensis), Kinnow (Citrus reticuleta), and Mosambi (Citrus limetta) methanolic, the aqueous extract showed the inhibitory activity on α-amylase and α-glucosidase assay where methanolic, acetone and aqueous extract of these fruit peels exhibited the anti-hypertensive activities. The results showed that the methanol and aqueous extract of Orange, Kinnow, and Mosambi peels inhibited ...
EVALUATION OF THE PHARMACOPHORIC ACTIVITY OF DIFFERENT COMPOUNDS OBTAINED BY GC-MS IN AQUEOUS EXTRACT OF LAWSONIA ALBA
Most of the medications currently in use are largely derived from the traditional plants and their products. Lawsonia alba, often known as henna, has a wide range of medicinal uses, from minor infections to cancer and is also used as a hair dye. All of these pharmacological actions and therapeutic uses are because of the presence of numerous secondary metabolites. These were isolated using the GC-...
EVALUATION OF IN-VIVO ANTI-AGGRESSIVE ACTIVITY OF EXTRACTS OF ALSTONIA SCHOLARIS LEAVES AGAINST ANIMAL MODELS OF AGGRESSION
Aggressive behavior is an important prerequisite for acquiring and maintaining feeding resources, territory and mating partners and, therefore, for the survival of an individual and the species. However, dysregulation of aggression among conspecifics can lead to severe injury and death. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydr...
VALIDATED METHOD FOR THE SIMULTANEOUS DETERMINATION OF EMTRICITABINE, BICTEGRAVIR AND TENOFOVIR ALAFENAMIDE IN PHARMACEUTICAL DOSAGE FORM USING UPLC
The proposed study aimed to develop and validate a method for the simultaneous determination of emtricitabine, bictegravir, and tenofovir alafenamide in pharmaceutical dosage form using ultra-ultra dosage performance liquid chromatography (UPLC). The drugs were separated using HSS C18 (100 x 1.8mm, 1.7m) column with a mobile phase composition consisting of 0.1% orthophosphoric acid (pH 2.2) and ac...
IN-SILICO VALIDATION OF CLOVE AS A POTENTIAL NUTRACEUTICAL AGAINST SARS-COV-2
The pandemic COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has killed millions of human beings throughout the world and attaining natural immunity against this virus is the best remedy. Consumption of nutraceuticals having antiviral and immune-boosting ingredients is the natural way to fight against it. The main objective of the present study was to evaluate the a...
FORMULATION AND IN-VITRO CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLET OF DEXIBUPROFEN
Dexibuprofen is a Non-Steroidal Anti-Inflammatory Drug. It indicated short-term management of mild to moderately severe acute pain, dental pain, dysmenorrhoea, muscular pain and osteoarthritis. In the prevailing work, studies have been carried out on the preparation and in-vitro characterization of matrix tablets of dexibuprofen using different polymers like hydrophilic and hydrophobic. Different ...
HOMOLOGY MODELLING AND ANALYSIS OF PROTEIN DRUG TARGETS FOR ERYSIPELOTHRIX RHUSIOPATHIAE A BACTERIAL PATHOGEN CAUSING SWINE ERYSIPELAS
Aim of this study was to generate 3D models of protein drug targets in Erysipelothrix rhusiopathiae by homology modelling. E. rhusiopathiae causes swine erysipelas disease that has great economic impact on the pork industry. Bioinformatic databases such as Uniprot KB, Drug Bank, PMDB and online tools such as BLASTp, SWISS Model and Ramachandran plot analysis and software such as Autodock4 and Pymo...
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF BISOPROLOL FUMARATE
The main objective of this research work was to formulate and evaluate an Orodispersible tablet of Bisoprolol Fumarate for the treatment of hypertension and coronary artery disease. Formulation was designed using systat software version 13.2. 32 full factorial design was applied, in which two variables were varied at three levels. The tablets of Bisoprolol Fumarate were developed by direct compres...
PREDICTION OF POTENTIAL DIETARY COMPOUNDS AGAINST HER2: AN IN-SILICO ASSESSMENT
Presently, in-silico approaches have been introduced as alternative methods for the process of drug invention. The current investigation aimed to explore expectations and the examination of the chemotherapeutic potential dietary phytochemicals as effective anti-cancer agents against HER2. This receptor plays a pivotal role in the development of breast cancer. Here, protein-ligand virtual screening...
ETHNOBOTANICAL STUDY OF MEDICINAL PLANTS USED BY THE DIFFERENT TRIBAL COMMUNITIES IN NILAKH- SRIPANI AREA OF DHEMAJI DISTRICT, ASSAM
Due to plentiful wild plant diversity, poor road conditions to connect modern medical facilities, and age-old folk knowledge on medicinal plants, the tribal communities of Dhemaji District, Assam, India, still practice traditional plant-based therapy in the management of primary healthcare. The present investigation aims to represent the ethnobotanical knowledge of different ethnic community peopl...
CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SEED EXTRACT OF N. NUCIFERA
N. nucifera, often recognized as lotus, is an aquatic plant. Extracts of various solvents have shown therapeutic potential against many diseases. This research focused on screening preliminary qualitative phytochemicals and investigating the seed's antioxidant activity. Primary and secondary metabolites were discovered in a hydroethanolic fraction of different extracts of lotus seeds. The extract...
INVESTIGATION OF ANTI-SWARMING, ANTI-BIOFILM AND ANTI-QUORUM SENSING POTENTIAL OF SOME ORGANIC TEA OF DIFFERENT BRANDS FROM INDIA
The emergency to find a solution to multidrug resistance of bacteria due to the abuse of antibiotics leads to the search for new antibacterial pathways. Quorum sensing (QS), or bacterial cell to cell communication, is a cell-density-dependent bacterial response. It is mediated by hormone-like compounds called autoinducers (AIs). QS-dependent regulation of gene expression controls various phenotype...
PREDICTION OF POTENTIAL INHIBITORS SIMILAR TO REMDESIVIR (GS-5734) AGAINST 7BTF SARS COV 2 RNA DEPENDENT RNA POLYMERASE – AN IN-SILICO APPROACH
The novel Corona Virus Disease - 19 (COVID-19) is a Contagious disease spreading among Animals and Humans, a Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS CoV2). The First case was identified in Wuhan, China as the disease has unfolded worldwide to the continuing pandemic. It created more infected cases and deaths worldwide, creating an urge for newer drugs of manipulate the Ongoing Pandem...
ADD-ON EFFECT OF SELECTED AYURVEDIC TREATMENT PROTOCOL IN FOCAL SEIZURES EVOLVING TO GENERALIZED SEIZURES – A NON-RANDOMIZED CONTROLLED TRIAL
Epilepsy is a chronic non-communicable disease that affects 50 million people worldwide. AEDs play a vital role in controlling seizures but are not a permanent solution. For a large percentage of Persons with Epilepsy, seizures happen even with the intake of AEDs. Apasmāra is more or less compared to epilepsy. The majority of studies conducted on Apasmāra were śamana therapies and suggested śo...
IDENTIFICATION AND ISOLATION OF BIOACTIVE COMPONENTS USING GC-MS, UV VISIBLE, FTIR, HPLC, HPTLC AND ANTIOXIDANT ACTIVITY PRESENT IN ETHANOLIC EXTRACT OF INDIAN SPICES MIXTURE
Introduction: The spices, despite their taste and flavor, have certain therapeutical uses from ancient days. For this research work, we have chosen some selected spices indefinitely amount. Materials and Methods: Phytochemical analysis, mineral estimation Characterisations such as GC-MS, UV Visible & FTIR spectroscopy, HPLC, HPTLC, and Antioxidant activity were carried out. Results & Discu...
ISOLATION AND CHARACTERIZATION OF LEAF SPOT PLANT PATHOGENS FROM SPINACIA OLERACEA
Spinacia oleracea L. (child spinach) is a generally new leaf vegetable in the Amaranthaceae family. The crop is high in human supplements and generally has significant degrees of bioactive mixtures like nutrients A also C and minerals. In the present study, the fungi and bacteria from the infected leaves of Spinacia oleracea are isolated and morphological identified. DNA isolation of the cultured ...
ACYCLOVIR LOADED GELATIN BIODEGRADABLE NANOPARTICLES: FORMULATION, OPTIMIZATION, CHARACTERIZATION, AND IN-VIVO EVALUATION
Acyclovir has a ratified antiretroviral effect for Herpes simplex virus type 1 (HSV-1), HSV-2, Varicella zoster virus (VZV), Herpesvirus simiae and to a minor extent, Epstein-Barr virus (EBV). The oral bioavailability of acyclovir is indigent, with only 15%–30% of the oral formulations' vitality absorbed. To baffle the issue of insignificant bioavailability, acyclovir was formulated into biodegr...
PHARMACOGNOSTICAL STANDARDIZATION AND PRELIMINARY PHYTOCHEMICAL INVESTIGATIONS ON ANANAS COMOSUS (L.) MERR.
Pineapple or 'Ananas,' is a tropical fruit that belongs to the Bromeliaceae family. The stem and fruit of this plant are utilized in conventional and folk medicine for treating various illnesses. In addition to calcium, iron, potassium, pineapples are a rich source of vitamin C, B and A. This study involves determinations various standardization specifications for the plant Ananas comosus (L.) Me...
DEVELOPMENT AND VALIDATION OF NOVEL RP-HPLC METHOD FOR THESIMULTANEOUS ESTIMATION OF EZETIMIBE AND BEMPEDOIC ACID IN A TABLETDOSAGE FORM
A simple, novel, precise, and cost-effective reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated to simultaneously estimate ezetimibe and bempedoic acid in the marketed tablet dosage form. The chromatographic separation was carried out on a Prontosil C18 (250 x 4.6 mm, 5 µm) column using a mobile phase of Acetonitrile: water (60:40 v/v). The flow rate...
PREPARATION AND EVALUATION OF LIPID MICROSPHERE OF VERAPAMIL HYDRO-CHLORIDE
Microspheres drug delivery system have improved patient compliance, decreased toxicity, and increased efficacy. This work aimed to design a controlled-release drug-delivery system for lipid microspheres of Verapamil hydrochloride that would retain the drug in the stomach and continuously release the drug in a controlled manner up to a predetermined time. Lipid microspheres were prepared by using a...
PRODUCTION OF SINGLE-CELL PROTEIN FROM DARJEELING MANDARIN PEELS USING ASPERGILLUS NIGER AND ASPERGILLUS ORYZAE
Single Cell Protein (SCP) refers to the dead, dried cells of various microbes, including bacteria, yeast, algae, and fungi. This type of biomass can be obtained from economically cheap substrates like agro-wastes as a non-conventional proteintious source for human or animal feed. The bioconversion of Darjeeling mandarin peels into single-cell protein (SCP) was performed using Aspergillus niger and...
DESIGN, DEVELOPMENT AND CHARACTERIZATION OF SOLID DISPERSION OF QUERCITIN LOADED ORAL WAFERS
Quercetin (3, 3ʹ, 4ʹ, 5, 7-pentahydroxyl-flavone) is a flavonol, belonging to the class of plant secondary metabolites known as flavonoids. Quercetin and its derivatives have various beneficial effects against ailments like inflammation, oxidative stress, and cancer. The present research work aimed to prepare and characterize quercetin's solid dispersion (SD) to enhance solubility and thereby di...
ESTIMATION OF ANTIARTHRITIC ACTIVITY OF A POLYHERBAL FORMULATION AGAINST ADJUVANT INDUCED ARTHRITIS IN RATS
Objective: Rheumatoid arthritis (RA) is a systemic disorder which involves the activation of immune system against the self-tissues. The main targets of this disease are the joints. Being systemic, the development of this disease involves different mechanisms, and thus, the exact cause of this disease remains unknown. Although different drugs have been developed, none has been found to be the cure...
PREPARATION AND EVALUATION OF EXTENDED-RELEASE MICROSPHERES OF QUETIAPINE FUMARATE
The objective of present study was to develop extended release microspheres of quetiapine fumarate using Eudragit RS 100 and Eudragit RL100 to reduce the dosing frequency. The quetiapine fumarate-loaded Eudragit microspheres were formulated by a solvent evaporation method. A 32 factorial design was employed to study the effect of concentration of sodium lauryl sulfate (SLS) and drug: polymer ratio...
EVALUATION OF ANTIFUNGAL EFFECTS OF PLANT LEAVES EXTRACTS ON ISOLATED RHIZOPUS SPECIES FROM SOIL
Mucormycetes are a group of fungi causing a serious infection called mucormycosis. These fungi live throughout the environment, particularly in soil than in the air. This fungus is severely spread among people who have weakened immune systems; breathing in these spores can cause severe infection in the lungs or sinuses, which can spread easily to other parts of the body. In the present work, Rhizo...
ASSESSING THE ANTIOXIDANT ACTIVITIES OF METHANOLIC EXTRACT OF SARACA ASOCA LEAVES AND BARK
Chronic diseases such as cardiovascular, cancer, and respiratory diseases are being increased. Reactive oxygen species, free radicals, and oxidative stress play a major role in aggravating these diseases. Plants and plant-derived compounds have shown a greater potential in combating the detrimental effects of free radicals and other toxic agents. The current research work has been done on the leaf...
EFFECT OF EDUCATIONAL INTERVENTION ON MATERNAL KNOWLEDGE IN USE OF ANTIBIOTICS IN ACUTE RESPIRATORY INFECTIONS AMONG UNDER FIVE CHILDRENIN URBAN FIELD PRACTICE AREA OF MEDICAL COLLEGE BANGALORE
Background: Acute respiratory infections are the most important cause of mortality and morbidity among under-five children in developed and developing countries in the world. There is lack of awareness/ knowledge among parents regarding antibiotic use in children for minor respiratory ailments. Hence, the present study was undertaken. Methods and Methodology: After taking institutional ethical cle...
EXTENSIVE STUDY ON RETT SYNDROME: A CASE REPORT
Rett Syndrome is an extremely rare, post-natal, and serious genetic neurodevelopmental syndrome that occurs mostly in female children. It occurs due to the mutations in the MeCP2 gene of the X chromosome. Children with Rett syndrome are usually diagnosed within 24 months of their age. The mutation takes place on the S421 site of the MeCP2 gene. The information for coding MeCP2 protein is obtained ...
METABOLIC DEFECTS OF THYROID HORMONE IN THE EMBRYONIC STAGE AUGMENT THE RISK OF DEVELOPING GESTATIONAL DIABETES MELLITUS AND OTHER SUSCEPTIBLE FACTORS
The objective of the study is to elucidate the association between thyroid dysfunction and increased risk of developing gestational diabetes mellitus (GDM) and assess the other risk factors for developing GDM. Retrospective observational research was carried out on 204 patients. Of these, pregnant women greater than 18 years were considered and recruited based on inclusion and exclusion criteria. ...
ANTIBACTERIAL ACTIVITY OF FIVE SPECIES OF MARINE MICROALGAE
Antibacterial activity of five marine microalgae Isochrysis galbana, Chaetoceros calcitrans, Tetraselmis suecica, Nannochloropsis oculata, Aphanocapsa sp. was studied from Visakhapatnam. The ethanolic extract of T. suecica, C. calcitrans, and N. oculata s howed inhibitory activity against V. harveyi and S. Aureus with inhibition zone between 11.5 and 20mm. The ethanolic extract of I. galbana showe...
ANTIDEPRESSANT ACTIVITY AND PHARMACOGNOSTIC EVALUATION OF ETHANOLIC EXTRACT OF STREBLUS ASPER LOUR
Streblus asper Lour is traditionally used for anti-diarrheal and anthelmintic activity. The present study aims to prove the antidepressant activity in a different extract of leaves of S. asper Lin animal models. The extracts of Sterblus asper L. significantly reduced the immobility time in the forced swimming test (FST), notable at 400 mg/kg when compared with the control group. The immobility tim...
FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF TOPICAL FILM-FORMING SOLUTION FOR TREATMENT OF DIABETIC FOOT ULCER
Diabetic foot ulcer is one of the leading causes of lower limb amputation and mortality in diabetic patients. Various factors contribute to the manifestation of chronic wounds in diabetic foot, but ischemia, infection, and elevated levels of matrix metalloproteases enzyme are the main factors. Matrix metalloproteases (MMPs) are elevated to as high as 60%. Thus, altering the wound-healing process. ...
CELECOXIB, A SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, IS ANTICONVULSIVE IN MES INDUCED SEIZURES BUT PROCONVULSIVE IN PTZ INDUCED SEIZURES IN MICE: A POSSIBLE ROLE OF EXCITATORY AMINO ACID IN THIS DIFFERENTIAL EFFECT
Epilepsy is an achronic neurological disorder characterized by recurrent seizures. There is a positive feedback cycle between epileptogenesis and brain inflammation. It has been proved that COX 2 is expressed constitutively in certain parts of the CNS and is further induced as a result of seizurogenic activity. Of the various experimental models of epilepsy, one is the maximal electroshock (MES) m...
IN-VIVO ANTI-CANCER AND HISTOPATHOLOGY STUDIES OF MORINGA OLEIFERA ON EHRLICH ASCITIC CARCINOMA CELLS
Moringa oleifera is an important food commodity with enormous attention as the 'natural nutrition of the tropics. Leaves of this plant are traditionally known for or reported to have various biological activities, including hypocholesterolemic agent, antidiabetic, gastric ulcers, antitumor and hypotensive agent. This study was designed to assess the toxicological and histopathological effects of e...