Volume 15 (2024) - Issue 9, September
Review Articles
SIGNIFICANT ROLE OF NUTRACEUTICALS AND FUNCTIONAL FOODS IN THE MANAGEMENT OF METABOLIC SYNDROME
Metabolic syndrome is the most widely and prevailing health concern globally. It is a cluster of biochemical and physiological abnormalities that involve obesity, insulin resistance, dyslipidemia, and hypertension. Several studies have reported that the prevalence of the overall metabolic syndrome rate in adults is about 25% (approx. 31% in women and 18.5% in men) in India. Whereas the global prev...
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CLASSICAL INFERENCES, BOTANICAL IDENTITY, CHEMICAL COMPOSITION AND THERAPEUTIC EFFICACY OF DINESAVALLI – AN IMPORTANT AYURVEDIC DRUG
Dineśavallīor Vēṁpātais a very popular Ᾱyurvēda herb used in South India for skin related ailments. In Kerala it is used in different formulations either as single drug or in combinations. There are no direct references to dineśavallī or Vēṁpāta in any bŗhatrayī or laghutrayī. From the previous studies it is confirmed that dineśavalli of south India is equated with ‘Ratanjot...
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CONCISE OVERVIEW ON OVARIAN CANCER AND ITS TREATMENT PARP INHIBITOR, TARGETED DRUG THERAPY, IMMUNOTHERAPY AND MORE
The primary cause of death for women with gynaecological cancer diagnoses is ovarian cancer. It is also, generally speaking, the sixth most common cause of death for women. The majority of cases had advanced diagnoses, which worsens the disease's prognosis. The limited predictive value of the current screening tests adds even more suffering to the situation. The most important early detection tech...
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ADDITIVE MANUFACTURING: EXPLORING THE IMPACT OF 3D PRINTING ON SOCIETY AND INDUSTRY
3D printing (a.k.a. fast prototyping or advanced manufacturing process) is estimated to be a highly innovative technology within the healthcare devices industry and pharmaceutical industry. With the use of digitally controlled material deposition straight from a computer-aided design, 3D printing technology can create 3D pharmaceutical items layer by layer. It facilitates the making of dosage form...
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UNRAVELING THE POTENTIAL, A COMPREHENSIVE ANALYSIS OF COMBINATORIAL CHEMISTRY
In the pharmaceutical industry, combinatorial chemistry has emerged as a novel approach, facilitating the synthesis of multiple compounds simultaneously rather than focusing on individual compound. The quick production of the chemical means that this technology reduces the time and expense involved in drug research. In this review article, the topic of combinatorial chemistry is discussed in gener...
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A REVIEW ON SCOPE OF ARTIFICIAL INTELLIGENCE IN PHARMA
Artificial Intelligence (AI) focuses on producing intelligent modelling, which helps in imagining knowledge, cracking problems and decision-making. Recently, AI played an important role in various fields of pharmacy like drug discovery, drug delivery formulation development, poly-pharmacology, hospital pharmacy, etc. In drug discovery and drug delivery formulation development, various Artificial N...
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NANOFORMULATION OF HERBALS: A QUANTUM LEAP IN MEDICINAL PLANT APPLICATIONS
Herbal medicines, with their rich history of use, often face challenges in achieving optimal effectiveness due to low absorption rates and limited bioavailability of their phytoconstituents. While these constituents are typically water-soluble, their inability to penetrate lipid membranes compromises their efficacy. To overcome these limitations, integrating herbal drugs with nanotechnology has em...
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DRUG DISCOVERY AND DEVELOPMENT PROCESS IN INDIA, US, EUROPE AND JAPAN
An overview of the drug discovery and development process in brief helps scientists whose work could be important in deciding the process to properly design their research report for the successful translation of preclinical research to human subjects. The idea for the drug's discovery and development may have come from a variety of sources, including the demands of the market at the time, clinica...
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Research Articles
ETHNONUTRITIONAL INVESTIGATION, ANTIOXIDANT ACTIVITIES AND SECONDARY METABOLITE CONTENT OF A RANGE OF MUSHROOM TEAS BASED ON PLEUROTUS PULMONARIUS, PLEUROTUS OSTREATUS AND PLEUROTUS FLORIDANUS
Oyster mushrooms are considered functional foods due to their structure. Our work focused on assessing the antioxidant power and determining the secondary metabolite content of mushroom teas formulated from the best-known, cultivated and eaten species. We carried out an ethnonutritional survey, and the species selected were used for the rest. We implemented a mixing plan after which 13 formulation...
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NEW FLAVONOL GLYCOSIDE FROM GUIBOURTIA EHIE (FABACEAE)
Guibourtia ehie (A. Chev.) J. Leonard is a medicinal plant widely used in the Ivorian traditional medicine against stomach ulcers, sexual infections, diabetes, hypertension and microbial infections, particularly those caused by amoeba and fungi. Furthermore, this plant is widely known for its commercial interest due to economic value of its wood. Biological and phytochemical investigations also co...
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DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF PROPROTEIN CONVERTASE SUBSTILSIN/KEXIN TYPE 9 INHIBITORS AS POTENT ANTI-HYPERLIPIDEMIC AGENTS
Hyperlipidemia is a systemic disease, which is characterized by elevated lipid levels in blood including total cholesterol (TC), total glyceride (TG), low density lipoprotein cholesterol (LDL-c) and so on. It is one of the major risk factors leading to fatty liver, cardiovascular diseases and atherosclerosis and become the first killer of human health. The present study involves synthesis of some ...
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PROTECTIVE EFFECT OF QUERCETIN ON METHOTREXATE INDUCED TOXICITY IN WISTAR RATS
Methotrexate (Mtx) is used to treat a number of conditions, including certain types of malignancy. Therefore, the purpose of this study was to investigate the potential protective impact of flavonoid quercetin on toxicity caused by methotrexate using hematological, biochemical, histopathological and oxidative stress approaches. There were four different groups, each group consisting of ten rats. T...
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PRECLINICAL ASSESMENT OF WOUND HEALING ACTIVITY OF SEED EXTRACT OF AZADIRACHTA INDICA
Medicinal plants are important for pharmacological research and drug development. Aim and Objective: The aim and objectives of present study was to evaluate the wound healing activity of seed oil of Azadirachta indica in Excision and Incision wound models in rats. Result Discussion: The study thus demonstrated the wound healing activity of Neem seed oil and found to be effective in the functio...
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RED CELL DISTRIBUTION WIDTH ASSESSMENT AND HEMATOLOGICAL CORRELATION IN OVARIAN CANCER
Ovarian cancer, a major concern in India, is among the leading causes of cancer-related deaths in women. Early detection is crucial due to frequent late-stage diagnoses. Red Cell Distribution Width (RDW), a marker for red blood cell size variability, is promising but lacks extensive study in ovarian cancer. This research aims to correlate RDW with hematological parameters in ovarian cancer patient...
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STUDIES ON ANTIBACTERIAL ACTIVITY, ANTIOXIDANT ACTIVITY AND GC-MS ANALYSIS OF NIGELLA SATIVA SEEDS
The Nigella sativa seeds were collected from Cuddalore and powdered thoroughly by using mortor and pestle. The Nigella sativa seeds were individually extracted with different solvents such as ethanol, methanol, acetone and water. The antibacterial activity of seed extracts were tested against the 6 ATCC pathogens such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Clostridium s...
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DESIGN AND VALIDATION OF NOVEL UV-VISIBLE SPECTROSCOPIC METHOD FOR ASSAY OF AMPHOTERICIN B
The objective of this research was to design and validate an alternative accurate method for quantitative determination of Amphotericin B. Amphotericin B deoxycholate life-saving drug belongs to the polyene class approved for the treatment of progressive and potentially fatal fungal infections. Amphotericin B was estimated at 382 nm and the percentage recovery was found to be 100.2 ± 0.34. The me...
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TO STUDY CLINICAL PROFILE AND DRUG PRESCRIPTION PATTERN AMONG DIABETIC PATIENT
The present study was aimed to analyze the prescription pattern of the diabetic patients with clinical profile with specific objective to determine the current trend of anti-diabetic drugs. According to the report obtained from the study, the male patients are more prone to diabetes mellitus than females. Type 2 diabetes mellitus is widely observed where study was carried out. There is the need fo...
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EFFICACY OF OA NOSODE 30C IN THE MANAGEMENT OF OSTEOARTHRITIS OF KNEE JOINT IN THE AGE GROUP OF 21 TO 80 YEARS – A CLINICAL STUDY
“Similia Similibus Curentur," is the therapeutic law of nature on which Homoeopathy is based. This means "Let like be treated by likes," with a holistic and dynamic concept. As mentioned in aphorisms no. 6 and 7 (Organon of Medicine, 6th edition of Master Hahnemann) for selection the similimum, the homoeopathic physician forms a portrait of the patient after taking the history and framing "Total...
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MUZZLE AREA INVOLVEMENT – AN UNUSUAL PRESENTATION IN LEPROSY
Lepromatous leprosy is a chronic infectious disease caused by Mycobacterium leprae, characterized by the extensive involvement of skin and peripheral nerves. While it commonly affects the cooler regions of the body, such as the extremities, ears, and face, involvement of the muzzle area is exceedingly rare. We present a unique case of lepromatous leprosy in a 42-year-old male, where the initial ma...
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COMPUTATIONAL EXPLORATION OF SMALL MOLECULES AS INHIBITOR TARGETTING CYTOCHROME P4502D6
Cytochrome P450 2D6 (CYP2D6) is an essential enzyme that affects the safety and effectiveness of a broad range of medications through its metabolism. We provide here an extensive in-silico investigation of new drug candidates that target CYP2D6. To find putative CYP2D6 inhibitors, we used virtual screening, structure-based drug design, molecular docking, and simulation approaches in the Biovia Di...
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VALIDATION OF THE IAC YOKOHAMA SYSTEM FOR REPORTING BREAST FINE NEEDLE ASPIRATION CYTOLOGY AND HISTOPATHOLOGICAL CORELATION OF BREAST LESIONS IN VINDHYA REGION POPULATION
Background: Breast cancer is commonest malignancy of women globally. A palpable breast lump is common diagnostic dilemma to surgeons. In 2016,International Academy of Cytology (IAC) established a standardized approach for reporting Breast FNAC by categorizing the lesions in five tier system from C1 to C5 to standardize reporting, which will enhance Breast FNAB cytology performance, interpretation,...
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ASSESSMENT OF COLD CHAIN FUNCTIONING IN POST EVIN ERA IN NAINITAL DISTRICT
Background: A vaccine supply chain is the complex system of steps, processes, equipment, vehicles and locations involved in getting vaccines from their origin to their destination. Failure to understand and properly address this system can greatly reduce the impact of any vaccine. It is also necessary that the condition of cold chain equipment i.e., deep freezer and ice- lined refrigerator (ILR) i...
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ACUPUNCTURE TREATMENT FOR RIGHT HIP OSTEOARTHRITIS AS A COMPLICATION OF LEFT HIP CONGENITAL DISLOCATION – A CASE REPORT
Osteoarthritis in the hip creates a major cause of pain and functional limitation. Acupuncture is an effective treatment for reducing inflammation and protecting muscles and produce pain control associated with disorder. Acupuncture is a proven, comprehensive method that helps to restore normal body function. The aim of this study is to find out the effect of acupuncture for relieving chronic hip ...
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EFFECT OF MICROBIAL BIOINOCULATION ON THE BIOACTIVE SECONDARY METABOLITES PRODUCTION OF ELAEAGNUS LATIFOLIA L. SEEDLINGS
The role of rhizospheric symbiotic Arbuscular Mycorrhizal (AM) fungus, non-AM fungus and bacteria in biochemical metabolites production of E. latifolia L. seedlings was analysed. The seedlings were inoculated with AM fungal strain (Glomus species), non-AM fungus (Trichoderma harzianum, Th-13) and bacteria (Pseudomonas species, Ps-1) in combined form (both, dual and triple/tripartite consortium) an...
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CORRELATION OF DRUG RESISTANT PATTERN WITH BIOFILM PRODUCTION BY USING MICROTITRE PLATE METHOD IN CLINICAL ISOLATES OF KLEBSIELLA PNEUMONIAE
Health care associated infections (HAIs) are frequently caused by Klebsiella pneumoniae (K. pneumoniae) which has a high level of antibiotic resistance pattern and the ability to form biofilms. In this research work, 105 K. pneumoniae was isolated from both inpatients and outpatients between January 2021 and January 2022 at the tertiary care hospital viz, Mahatma Gandhi Medical College and Researc...
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CHARACTERIZATION OF UV-ABSORBING BENZOPHENONES FROM NATURAL AS WELL AS IN-VITRO ROOTS OF GARCINIA INDICA (THOUARS) CHOISY USING AN EFFICIENT HYPHENATED TECHNIQUE HPTLC-MS
Nowadays increase in UV induced skin ailments and adverse effects of synthetic UV filters, prompted researchers to focus on natural compounds capable of absorbing UV rays. Garcinia indica is a rich source of benzophenones, which are present in all plant parts. As per earlier reports, ethyl acetate root extract of it exhibits the highest SPF (7) than other plant parts. The present study aims to cha...
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REVEALING SILYMARIN: HPTLC METHOD DEVELOPMENT AND VALIDATION
Silymarin, an intricate blend of flavonolignans obtained from Silybum marianum, or milk thistle, has drawn a lot of interest because of its possible medical uses. This study reports on the development and validation of an analytical technique that employs high performance thin layer chromatography (HPTLC) to estimate silymarin in pharmaceutical dosage forms (tablet) and bulk drug. Chloroform: meth...
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A COMPARATIVE STUDY TO ASSESS THE EFFICACY OF CLINDAMYCIN WITH TRETINOIN VERSUS CLINDAMYCIN WITH NICOTINAMIDE IN MILD TO MODERATE ACNE VULGARIS
Introduction: Acne is characterized by non-inflammatory follicular papules or comedones and by inflammatory papules, pustules and nodules and is estimated to affect 9.4% of the global population. Topical combination therapy is the first-line approach for facial acne. Objectives: To compare the efficacy and safety of topical clindamycin 1% with tretinoin 0.025% and clindamycin 1% with nicotinamide...
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DESIGN AND EVALUATION OF BILAYER & TRILAYER TABLET COMBINATION OF ANTIRETROVIRAL DRUGS
A non-nucleoside reverse transcriptase inhibitor (NNRTI) is Nevirapine. Zidovudine and Lamivudine are antiretroviral medications that are members of the nucleoside analogue class. Combination of three drugs commonly used in the management of the Human Immunodeficiency Virus (HIV) infection. Nevirapine exhibits a decent initial release, while Zidovudine and Lamivudine demonstrate sustained release ...
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COMPARISON OF CATECHIN PROFILES (CAMELLIA SINENSIS) IN ALCOHOLIC SMOKERS’ PLASMA AND URINE
Cigarette smoking and excessive chronic alcohol consumption are accepted risk factors for the causation of various diseases and disorders. Globally 2.5 billion alcoholics and 2.0 billion smokers exist (WHO, 2018). The comorbidity of alcohol and cigarette smoking is highly prevalent. This study is designed to investigate the influence of green tea an effective therapeutic agent to treat the damage ...
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METHOD DEVELOPMENT AND VALIDATION OF DISSOLUTION METHOD FOR SITAGLIPTIN TABLETS BY UPLC
A fast, efficient and defined method was developed for the real-time assessment of Sitagliptin in tablet dosage form. Dissolution method was developed and carried out to predict in-vivo drug release profiles of Sitagliptin tablets. Rate and extent of dissolution of Sitagliptin tablets was studied in different dissolution medias i.e. 0.1 N HCL, pH 4.0 Acetate buffer and pH 6.8 Phosphate buffer usin...
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