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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 6 (2015) - Issue 10, October

Review Articles

 
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1.

MEDICINAL PLANTS: THEIR USE IN ANTICANCER TREATMENT

Globally cancer is a disease which severely effects the human population. There is a constant demand for new therapies to treat and prevent this life-threatening disease. Scientific and research interest is drawing its attention towards naturally-derived compounds as they are considered to have less toxic side effects compared to current treatments such as chemotherapy. The Plant Kingdom produces ...

M. Greenwell and P.K.S.M. Rahman*

School of Science and Engineering, Teesside University, Middlesbrough –TS13BA, Cleveland, United Kingdom

DOI: 10.13040/IJPSR.0975-8232.6(10).4103-12

4103-12

8458

2882

2.

A REVIEW ON RECENT DEVELOPMENT OF PYRAZOLINE AS A PHARMOCOLOGICALLY ACTIVE MOLECULE

Pyrazoline, among the various 5-membered heterocyclic compound derivatives has drawn attention towards it because of its various pharmacologically activities associated with it. Pyrazolines are a five membered heterocyclic having two adjacent nitrogen atoms within the ring with only one endocyclic double bond and is basic in nature. A lot of research work has been done on synthesis and biological ...

Rubina Bhutani *, Dharam Pal Pathak , Asif Husain , Garima Kapoor and Ravi Kant

Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4113-28

4113-28

4153

1670

3.

ETHOSOMES: UNIQUE ELASTIC VESICULAR CARRIER – AN OVERVIEW

Ethosomes are phospholipid-based elastic vesicles which have a potential as novel topical and transdermal drug delivery systems. They are ethanolic phospholipids vesicles which can act as carriers for various medicaments. Ethosomes have gained importance in the area of research, because of their intensified skin permeation, better delivery of drug and increased drug entrapment efficiency. These sy...

A. Mistry*, P. Ravikumar and S. Pathare

Department of Pharmaceutics, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W). Mumbai, M.S. India

DOI: 10.13040/IJPSR.0975-8232.6(10).4129-36

4129-36

2418

1541

4.

NANOTECHNOLOGICAL APPROACHES TO HERBAL DRUGS USED IN CANCER THERAPY

In the last few years there has been an exponential growth in the field of herbal medicine and these drugs are obtaining popularity both in developing and developed countries because of their natural origin and lesser side effects. Many traditional medicines in use and they are derived from medicinal plants, minerals and some organic matter. The World Health Organization (WHO) has listed 21,000 pl...

Abdul Qadir, Nida Khan, Satya Prakash Singh*, Juber Akhtar and Muhammad Arif

Faculty of Pharmacy, Integral University, Lucknow, Utttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4137-44

4137-44

3379

1539

5.

PIPERAZINE – A BIOLOGICALLY ACTIVE SCAFFOLD

The broad and potent activity of piperazine has established it as one of the biologically important scaffolds. This article is an effort to highlight the importance of the piperazine in the present context and promise they hold for the future. This review mainly focused the updated information on the most active piperazine derivatives that have been reported to show significant biological actions ...

K. Singh *, H.H Siddiqui, P. Shakya , P. bagga , A. Kumar, M. Khalid, M. Arif and S. Alok

Faculty of Pharmacy, Integral University Kursi Road, Lucknow (U.P.), India

DOI: 10.13040/IJPSR.0975-8232.6(10).4145-58

4145-58

3523

1871

6.

DRUG SAFETY ASSESSMENT IN CLINICAL TRIALS: CONCEPTS AND ISSUES

Ensuring patient safety during and after clinical trials is the sole priority of the drug-development process. In both clinical trials and clinical practice, each patient must be treated according to his or her illness and needs. For this purpose, monitoring of patient safety at all levels of drug-development is given utmost importance. Such monitoring is a dynamic process having motive of protect...

Naveen Nautiyal*, Rajul Rastogi and Hans-Joachim Gamperl

Global vigilance, Fresenius Kabi Oncology Limited, Gurgaon, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4159-67

4159-67

2884

592

7.

CURCUMA LONGA: BOON FOR HEALTH CARE SYSTEM WITH ITS BIOMEDICAL APPLICATION

Turmeric is a spice derived from the rhizomes of Curcuma longa, which is a member of the ginger family (Zingiberaceae). Turmeric constituents include the three curcuminoids: Curcumin (diferuloylmethane; the primary constituent and responsible for its vibrant yellow color), demethoxycurcumin, and bisdemethoxycurcumin, as well as volatile oils (tumerone, atlantone, and zingiberone), sugars, proteins...

Khursheed Ahmad *, Vaseem A. Ansari, Kuldeep Singh, Poonam Kushwaha and Juber Akhtar

Faculty of Pharmacy, Integral University, Kursi Road, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4168-73

4168-73

1821

885

Research Articles

 
Title
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8.

EFFECT OF AM FUNGI AND DIFFERENT SELENIUM LEVELS ON THE QUALITY OF SALVIA MILTIORRHIZA BGE

The effects of AM fungi on Salvia miltiorrhiza under different selenium levels was researched using pot technology. The results showed that inoculation of AM fungi significantly increased the plant height, root length, each part weight, chlorophyll, protein and selenium content of Salvia miltiorrhiza under the same selenium level, in addition, MDA and proline contents decreased significantly. It c...

L. I. Jianheng *, QIAO Yajun, Qi Junxiang, WU Hanqiu and YANG Xiaoyu

College of Pharmaceutical Sciences, Hebei University, Baoding Hebei, China

DOI: 10.13040/IJPSR.0975-8232.6(10).4174-80

4174-80

2137

892

9.

INVESTIGATION OF IN-VIVO PENETRATION AND DISTRIBUTION OF NANOMETRIC TiO2 IN TROPICAL ALBINISTIC SKIN BY SEQUENTIAL ADHESIVE TAPE STRIPPING

The non-invasive adhesive tape stripping technique was used to evaluate dermato-pharmacokinetics of nanometric titanium dioxide in tropical albinistic skin. Ten sequential strippings were conducted on exposure sites on the forehead, inner and upper forearms of three oculocutaneous albinism individuals 26+/- 4 years old, 15 minutes post dosing of 6.75mg/cm2 of a 5% titanium dioxide cream specifical...

J. Chifamba *, A. Dube and C. C. Maponga

College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe

DOI: 10.13040/IJPSR.0975-8232.6(10).4181-89

4181-89

1946

775

10.

PHYSICOCHEMICAL CHARACTERIZATION, MICROBIOLOGICAL QUALITY CONTROL AND TOXICITY EVALUATION OF THE HIDROETHANOLIC EXTRACT FROM CHENOPODIUM AMBROSIOIDES LINN

Chenopodium ambrosioides Linn, member of the National List of Medicinal Plants of Interest to SUS (RENISUS), is used to treat different diseases and shows good potential to generate products of interest to the Brazilian Unified Health System “Sistema Único de Saúde” (SUS). However, the use of herbal derivatives implies the control of their quality and the evaluation of their toxicity. Pharma...

É. da Silva Valério, Wagner Luiz Ramos Barbosa, Regina Maria Finger, Michelle Frazão Muzitano, Marlon Heggdorne de Araújo, Flavio de Vasconcelos and Francisco Martins Teixeira *

Programa de Pós-graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brasil

DOI: 10.13040/IJPSR.0975-8232.6(10).4190-97

4190-97

2499

1116

11.

A CLINICAL STUDY ON THE IMPACT OF DIFFERENT TREATMENT MODALITIES ON IMPROVING THE CLINICAL OUTCOMES IN CHRONIC PERIODONTITIS PATIENTS

Background: Periodontal disease is one of the two main and most prevalent oral diseases all over the world. Treatment strategies are diverse. To date, scaling and root planing (SRP) is still the gold standard non-surgical therapy for periodontitis. Systemically administered antibiotics can be used as an adjunct to SRP to improve the treatment outcome of periodontitis. Purpose: To compare clinical ...

DK Abou El-Fadl *, NA Sabri and HA Abuel-Ela

Department of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(10).4198-09

4198-09

1843

770

12.

BINGERVONE, AN ANTIPROTOZOAL β-TRIKETONE DERIVATIVE FROM THE ROOTS OF UVARIA AFZELII (ANNONACEAE)

Uvaria afzelii Scott Elliot (Annonaceae) is an African traditional medicinal plant. In Ivory Coast, roots of the plant are commonly used as antiparasitic and against others ailments. During our previous investigation on the roots one 1-indanone derivative was obtained together with other compounds that showing interesting antiprotozoal activities. The aim of this study was to isolate other antipro...

Timothée A. Okpekon *, Joel M. E. Dade, Martial V. Say, Denis K. Yapo , Pierre Champy , Blandine Séon-Méniel, Séri F. Yolou and Christian Bories

Laboratoire de Chimie Organique et de Substances Naturelles , Université Félix Houphouët Boigny, Côte d’Ivoire, Brasil

DOI: 10.13040/IJPSR.0975-8232.6(10).4210-15

4210-15

3654

908

13.

PREPARATION AND CHARACTERIZATION OF AN OILY SUSPENSION OF OMEPRAZOLE FOR ADMINISTRATION IN PEDIATRICS

The present research was focused on the development of an oily suspension for oral administration of omeprazole in Pediatrics. Currently, for the treatment of this population, extemporaneous preparations are used in hospitals with many limitations in their use as bad organoleptic features and loss of drug activity due to improper manipulation, causing the omeprazole to be sensitive to the acidic e...

M. R. Cruz-Sanmartín*, J. I. Pérez-Martínez and A. M. Rabasco-Álvarez

Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Sevilla. 41012 – Sevilla, Spain

DOI: 10.13040/IJPSR.0975-8232.6(10).4216-25

4216-25

2674

1430

14.

COMPARATIVE ANTIANXIETY ACTIVITY EVALUATION OF ARGYREIA SPECIOSA LINN. (ROOTS), CAESALPINIA DIGYNA ROTTLER (ROOTS) AND SPHAERANTHUS INDICUS LINN. (FLOWERS)

Aim of the present study was a comparative evaluation of antianxiety activity of three traditionally used medicinal plants — Argyreia speciosa (Roots), Caesalpinia digyna (Roots) and Sphaeranthus indicus (Flowers). The activity of various extracts (petroleum ether, chloroform, ethanol and water) of all the three plants was evaluated using elevated plus-maze model. The studies were conducted on l...

Ashwani Kumar*, Jitender Singh and Anupam Sharma

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4226-29

4226-29

2059

709

15.

ANTIOXIDANT ACTIVITY OF NEW POTENTIAL ALLELOCHEMICAL FROM STEMS OF CASSIA SIAMEA LAM.

A new potential allelochemical (A) m.f. C34H42O19, m.p 168-170 ◦C, [M]+ 754 (FABMS)   along with two known compounds  Scutellarin 7-O-β-D-glucopyranoside (B), Luteolin (C) were isolated from methanolic extract of the stems of Cassia Siamea Lam. The structure of  a new allelochemical (A) was characterized as 3,7-dihydroxy-5,3',4'-trimethoxyflavone-3-O-β-D-xylopyranosyl-7-O-α-L-rhamnopyrano...

Archana Chakravarty and R. N. Yadava*

Natural Products Laboratory, Department of Chemistry, Dr. H. S. Gour Central University, Sagar, (M.P.) India

DOI: 10.13040/IJPSR.0975-8232.6(10).4230-35

4230-35

1689

498

16.

SOLID DISPERSION ADSORBATE–A NOVEL TECHNIQUE FOR DISSOLUTION ENHANCEMENT OF FEBUXOSTAT

The objective of the present investigation was to improve dissolution characteristics of febuxostat, a BCS class – II drug, by formulating it as solid dispersion adsorbate. Solid dispersion adsorbate(SDA) was prepared using labrasol, transcutol and lutrol F127 as carriers and neusilin as adsorbent. Formulation was prepared using combination of melt and adsorption technique. Optimized formulation...

R. B. Pandya, T. A. Mehta * and M. C. Gohel

Institute of Pharmacy , Nirma University, Ahmedabad, Gujrat, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4236-42

4236-42

2382

1204

17.

MODULATORY ROLE OF WITHENIA SOMNIFERA ROOT EXTRACT MIXED PELLETED FEED ON PESTICIDE INDUCED HEPATIC ANOMALIES’ IN FRESH WATER CATFISH CLARIAS BATRACHUS (LINN.)

The pharmacological activity of Withenia somnifera commonly called Ashwagandha, a herb having multi-medicinal properties, was investigated   against carbofuran exposed hepatic anomalies in the air breathing fish Clarias batrachus. Fishes were exposed to 1 mg/L carbofuran for three weeks to induce the toxic effects. These fishes were then fed with Withenia somnifera root extract mixed pelleted fe...

Prakriti Verma and A. Nath*

Cell Biology & Toxicology Laboratory Department of Zoology, Patna University, Patna, Bihar, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4243-51

4243-51

2168

597

18.

ANTIOXIDANT, CYTOTOXIC AND PHYTOCHEMICAL PROPERTIES OF THE ETHANOL EXTRACT OF PIPER BETLE LEAF

The use of natural products for the treatment of various diseases has a long history. In the present study, the anti-oxidative, cytotoxic and phytochemical properties of ethanol extract of a local variety of Piper betle leaves cultivated in Potia, Bangladesh has been investigated. The antioxidant and cytotoxic activity of the Piper betle ethanol extract were evaluated by DPPH (1, 1-diphenyl-2-picr...

Md. Forhad Uddin *, Sheikh Aftab Uddin , Md. Delwar Hossain and Mohammed Abul Manchur

Department of Microbiology, University of Chittagong, Chittagong, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(10).4252-58

4252-58

2944

941

19.

HPTLC FINGERPRINTING, ANTIOXIDANT POTENTIAL AND ANTIMICROBIAL EFFICACY OF INDIAN HIMALAYAN LINGZHI: GANODERMA LUCIDUM

Ganoderma lucidum (Fr.) Karst., known as medicinal mushroom and it contains several bioactive phytochemicals such as polysaccharides, nucleosides, alkaloids, coumarin, ergosterols, ganoderic acids, lactones, mannitol, organic germanium, triterpenoids, unsaturated fatty acids, vitamins and minerals which are well known for their pharmacological properties. In the present investigation adenine, aden...

Vandana Kirar , Shubhi Mehrotra , Prem Singh Negi , Shoma Paul Nandi and Kshipra Misra *

Defence Institute of Physiology and Allied Sciences , DRDO, Lucknow Road, Timarpur, Delhi, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4259-68

4259-68

2378

611

20.

CHELATION THERAPY IN THE NEONATAL PERIOD: D-PENICILLAMINE CAN EXERT NEUROPROTECTIVE EFFECTS IN KERNICTERUS AND RETINOPATHY OF PREMATURITY

This review covers of the results of previously conducted retrospective and prospective clinical trials and data of Cochrane reviews to examine the effects of D-penicillamine (DPA) for neonatal hyperbilirubinemia and associated low incidence of retinopathy of prematurity (ROP). In the ABO- and Rh-Hemolytic Disease of the Newborn (HDN) DPA significantly reduced the need for both initial and repeate...

György Balla, Lajos Lakatos * and Zsuzsanna Vekerdy-Nagy

Kenezy Teaching Hospital , Department of Pediatrics, 4031Debrecen, Bartók B. str. 2-26, Hungary

DOI: 10.13040/IJPSR.0975-8232.6(10).4269-76

4269-76

2574

525

21.

EFFICIENCY OF A COST-EFFECTIVE UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CIPROFLOXACIN HCL IN MARKETED TABLET FORMULATION

A simple, reproducible and economical UV spectrophotometric method was developed for determining the potency of ciprofloxacin HCl in tablet dosage forms marketed in Bangladesh. Standard curves of ciprofloxacin HCl in the media of 0.1N HCl and distilled water were obtained by plotting absorbance versus concentration where calibration curve was found to be linear (r2>0.99). The average potency va...

Sultana Rajia, Imtiaj Hasan, Ruhul Amin and Md. Anwar Ul Islam*

Department of Pharmacy , University of Rajshahi, Rajshahi , Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(10).4277-83

4277-83

1768

552

22.

EFFECTS OF ALOE VERA ON LIVER OF SWISS ALBINO MICE AGAINST SUBLETHAL DOSE OF GAMMA RADIATION

The radioprotective effect of Aloe vera was studied in liver of Swiss albino mice. Animals were divided into three groups. Animals of group I administered double distilled water only, group-II Aloe vera (drug) and control set of group III were given radiation only where as animals experimental set of group III were administered by Aloe vera + Radiation. Animals were given Aloe vera leaf extract or...

Priyanka Dadupanthi

Department of Zoology, Biyani Girls College, Jaipur, University of Rajasthan, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4284-89

4284-89

1764

629

23.

PLACKETT-BURMAN SCREENING OF OLMESARTAN MEDOXOMIL LIQUISOLID TABLETS: QUALITY BY DESIGN APPROACH

Solubility is considered as the important parameters to achieve desired concentration of drug in systemic circulation for achieving required pharmacological response. Olmesartan medoxomil (OLM) is poorly soluble belongs to BCS class II. The drug is rapidly absorbed following oral administration, with a bioavailability approximately 26%.  Liquisolid technique was used to  enhance  the  aqueous...

Shantanu B. Kuchekar * and Shrinivas K. Mohite

Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon , Maharshtra, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4290-03

4290-03

1745

1007

24.

COMPARATIVE EFFECT OF AGOMELATINE VERSUS ESCITALOPRAM ON GLYCEMIC CONTROL AND SYMPTOMS OF DEPRESSION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND DEPRESSION

Introduction: A bidirectional relationship exists between type 2 diabetes mellitus (T2DM) and depression. There is dearth of research on comparative suitability of different antidepressants in people with T2DM and depression. Aim: To compare the effects of Escitalopram and Agomelatine on glycemic control and symptoms of depression in patients with T2DM and depression. Materials and Methods: We con...

Karun Kumar *, M. T. Salman , V. Shukla , A. Ahmad , V. K. Verma , D. A. Rizvi and A. Kohli

Department of Pharmacology, Era’s Lucknow Medical College and Hospital, Lucknow, U.P., India

DOI: 10.13040/IJPSR.0975-8232.6(10).4304-09

4304-09

2984

620

25.

EFFECTS OF CIGARETTE SMOKING ON SEMEN PARAMETERS OF MEN

Addicted smokers Semen analysis from a cross section of population of Anantapuramu district, Andhra Pradesh, India was done as it provides a useful profile of the function of the male reproductive health. Seventy two (72) men were drown from a cross section of smokers and divided in to two age groups namely 25-30 years and 31-40 years. In both age groups persons were selected basing as how many ci...

Kadiri Pullanna, Dereddy Nagalinga Reddy and Gundala Harold Philip*

Department of Zoology, Sri Krishnadevaraya University, Ananthapuram, AP, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4310-15

4310-15

1835

512

26.

EVALUATION OF ANTIOXIDANT EFFECT OF CITRULLUS VULGARIS AGAINST CADMIUM-INDUCED NEUROTOXICITY IN MICE BRAIN

Cadmium is a potent neurotoxic heavy metal, which induces oxidative stress and membrane disturbances in brain. Oxidative stress has been implicated in the pathology of number of neurodegenerative disorders including Alzeimers disease. The present study was aimed to evaluate the antioxidant effect of hexane extract of Citrullus vulgaris seed (CVSO) in the brain of cadmium (cd) treated mice as an an...

R. S. Adnaik*, P. S. Gavarkar and S. K. Mohite

Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, Tal Walwa, Dist Sangi , MS, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4316-23

4316-23

2060

560

27.

FORMULATION OF DIRECT COMPRESSED VERAMPAMIL SUSTAINED RELEASE FORMULATION USING OPTIMIZED CO PROCESSED EXCIPIENTS

Pharmaceutical excipients when co-processed have improved flow and disintegrant properties in tablet formulations. However, physical mixtures of excipients show limited functions, poor flow properties, and poor functional properties so they cannot be used directly in tablet formulations. Majority of solid dosage forms contain multiple excipients, which provides a wide window of opportunities by co...

P. Preetha*, A. Srinivasa Rao and C. Y. Priyanka

Department of Pharmaceutics, Bhaskar Pharmacy College, Hyderabad, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4324-35

4324-35

1610

645

28.

STUDIES ON PHTHALIC ACID-PROPANE-1, 2-DIOL-GLYCEROL CO-POLYESTER AS AN ENTERIC COATING MATERIAL

Enteric coating material that, was synthesized in the laboratory and applied to a tablet and also drug release profile was investigated. A polymeric material - Phthalic acid propane-1,2 diol-glycerol co-polyester (PPGC) was synthesized from phthalic acid and propane-1, 2-diol with 5% glycerol of total weight as a crosslinking agent using Dean-Stark apparatus with Ferric Chloride as catalyst and o-...

Md. Moinul Haque , Md. Saiful Islam *, Anath Chandra Roy and Md. Abu Bakr

Department of Applied Chemistry and Chemical Engineering, Rajshahi University, Rajshahi, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(10).4336-41

4336-41

1631

519

29.

QUALITY BY DESIGN APPROACH TO OPTIMIZATION OF TACROLIMUS LOADED PLGA NANOPARTICLES

The aim of the present study was to implement QbD approach to identify, evaluate and control critical process and formulation parameters and their impact on critical quality attributes (CQAs) and to establish design space with multifactorial combination which would provide high degree of assurance to achieve quality target product profile (QTPP). A risk assessment was performed with various proces...

Ajinath E. Shirsat* and Sohan S. Chitlange

Department of Pharmacy , JJTU, Jhunjhunu, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4342-53

4342-53

2880

698

30.

PHARMACOGNOSTIC STUDIES ON STEM BARK OF CORDIA OBLIQUA WILLD.

Cordia obliqua Willd var. obliqua. is a medium sized, broad leaved deciduous tree. It is found growing not only all over Asia but nearly the whole of the globe. Cordia obliqua (F. Boraginaceae) is traditionally used against fever, chest disease, leprosy, gonorrhoea and helminthes. Bark is bitter, mild astringent and tonic and used in general debility and convalescence. Decoction of the bark is use...

A. R. Bindu *, M. Sukumar and T. K. Ravi

Department of Pharm. Sciences, M G University, Cheruvandur campus, Ettumanoor, Kottayam, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4354-61

4354-61

1819

704

31.

SURVEY ON PATTERN OF SNAKE BITE CASES ADMITTED IN SOUTH INDIAN TERTIARY CARE HOSPITALS

Background: Snake bite is a problem across the developing countries, where agriculture is one of the main sources of income and India is one among it. Objective: The study was carried out to determine the pattern of snake bite in four different selected tertiary care hospitals of south India for a period of 03 years from March 2011 to March 2014. Material and Methods: A prospective observational s...

Kiran Nagaraju *, Nagappan Kannappan and K. Gopinath

Department of Pharmacy, Karpagam University, Coimbatore, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4362-67

4362-67

2024

708

32.

DESIGN AND DEVELOPMENT OF FAST DISSOLVING TABLETS OF HYDROCHLOROTHIAZIDE AND ATENOLOL CO-CRYSTALS

Hydrochlorothiazide (HCT) is a class IV drug which has limited solubility and permeability, for overcome this problems co-crystallization method is used. Co-crystallization is the process to enhance the physical properties of drug molecule especially the solubility. HCT belongs to diuretic category and Atenolol (ATL) belongs to Beta blocker category they are combined for use in tablet formulation....

O. S. Bhandwalkar *, M. U. Bhandwalkar, D. M. Ghadge, P. S. Dhekale, U. K. Jamdade

Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4368-74

4368-74

2361

898

33.

EVALUATION OF ANTI-STRESS ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF SAUROPUS ANDROGYNUS LEAVES

Anti-stress activity of hydro-alcoholic extract of Sauropus androgynous leaves was investigated against experimentally induced stress in rats using forced swimming endurance test and chronic cold restraint stress test. Acute toxicity study was performed and hydro-alcoholic extract of Sauropus androgynous leaves was found to be safe at a dose of 2000 mg/kg bodyweight. Two doses 200 mg/kg (SALE-200)...

Karunakar Hegde * and K. V. Divya

Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Post- Farangepete, Mangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4375-80

4375-80

2473

699

34.

COMPARATIVE STUDY OF HYPOGLYCEMIC EFFECTS AND ANTIOXIDANT POTENTIAL OF POLYHERBAL FORMULATION IN ALLOXAN INDUCED DIABETIC RATS AN ALTERNATIVE THERAPEUTIC AGENT FOR DIABETES MANAGEMENT

Objective: Comparative screening of Polyherbal preparations for anti-diabetic and antioxidant activity in rats. Materials and Methods: The blood glucose lowering activity of the Polyherbal preparation 1and 2 was studied in normal rats and alloxan-induced diabetic rats after oral administration at doses of 1.0  ml/kg body wt. Blood samples were collected from the tail vein method on 1,7, 15, and 2...

S. Shahana *, S. Shabana, G. Hundekari, Md. Saifuddin, A.G. Nikalje and S. Abdulla Yousuf

Kamala Nehru Polytechnic Pharmacy, Aurangabad, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4381-90

4381-90

2136

709

35.

EFFECT OF FICUS HISPIDA IN INFLAMMATORY BOWEL DISEASE IN EXPERIMENTAL ANIMALS

Background:  Inflammatory bowel disease (IBD) is an immune-mediated chronic intestinal condition. Conventional treatment regimens utilizing corticosteroids, anti-inflammatory and other immunosuppressive therapies have major limitations owing to their associated side effects and compliance issues. Objectives:  To evaluate the effect of ethanolic extract of Ficus hispida Linn. in inflammatory bowe...

V. Gunaseelan*, A. K. Karthikeyan, O. J. Singh, U. D. Meetei, Kh. K. Pramodini Devi and S Rita

Department of Pharmacology, RIMS, Imphal, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4391-97

4391-97

1742

717

36.

A STUDY OF INCORPORATION OF THERAPEUTIC VALUES OF WOOD APPLE (FERONIA LIMONIA SWINGLE) IN FRUIT BAR

The wood apple (Feronia limonia), called as elephant apple, has several medicinal properties. It is antiscorbic (prevent scurvy), a disease caused by lack of vitamin C (ascorbic acid). It is an antidote for poison and also helps in curing sore throat. The objective of the study was to incorporate medicinal properties of wood apple in fruit bar, a well accepted food product. The fruit bar was prepa...

Devendra Kumar Bhatt * and Abhilasha Jha

Institute of Food Technology, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4398-05

4398-05

2464

1026

37.

A STUDY OF PREGABALIN, TRAMADOL, THEIR COMBINATION AND NIGELLA SATIVA IN NEUROPATHIC PAIN IN RATS

Nigella sativa (NS) is a commonly used herb in Asian and African countries. Extensive experimental studies have been done to shed light on its hepatoprotective, immunumodulator, antioxidant, antimicrobial and several other useful pharmacological properties. However, there is dearth of evidence to evaluate the effect of Nigella sativa extract in neuropathic pain. In this study we have used neuropat...

S. N. Tewari *, M. T. Salman, S. Thadani, S. Singh, A. Ahmad

Department of Pharmacology, Era’s Lucknow Medical College, Sarfarazganj, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4406-14

4406-14

3049

680

38.

DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 1,2,4-TRIAZOLOPHENYL QUINOLINE-2-ONE DERIVATIVES

Heterocyclic compounds containing triazole ring are important targets in synthetic and medicinal chemistry because this key moiety in responsible for numerous biological activity. An efficient method for synthesis of novel derivatives of Substituted-1,2,4-triazolo phenyl quinolone was adopted by reacting various substituted aniline and cinnamic acid. The synthesized derivatives were designed to ha...

Swagatika Ghosh, Amita Verma *, Alok Mukerjee and Milan Kumar Mandal

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4415-23

4415-23

1846

675

39.

CLINICAL PHARMACIST INTERVENTIONS IN DRUG THERAPY IN PATIENTS WITH DIABETES MELLITUS AND HYPERTENSION IN A UNIVERSITY TEACHING HOSPITAL

Introduction: Drug related problems occur commonly in patients who often receive polypharmacy with multiple co-morbid conditions. This constitutes a major health problem because of their negative consequences with increased morbidity and mortality. Aims and Objectives: The aim of the study was to assess the impact of clinical pharmacist interventions in drug therapy in hospitalized diabetes mellit...

J. shareef, J. Fernandes and L. N. Samaga

Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, Paneer, Mangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4424-32

4424-32

3450

831

40.

RENOPROTECTIVE EFFECT OF OCIMUM SANCTUM IN COMPARISON WITH OLMESARTAN MEDOXOMIL AND PITAVASTATIN IN METFORMIN TREATED DIABETIC RATS

Nephropathy is an important comorbidity associated with diabetes leading to chronic kidney disease. We studied the effect of Ocimum sanctum in comparison to Olmesartanmedoxomil, Pitavastatin and their combination in prevention of this comorbidity. Male Wistar rats were given streptozotocin to induce diabetes and randomly divided into groups. Group 1 (Control group) received Metformin (94.5mg/kg/da...

S. Thadani *, M. T. Salman, S. Tewari, S. Singh, D. Bhagchandani and A. Ahmad

Era’s Lucknow Medical College, Sarfarazganj, Hardoi Road, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4433-41

4433-41

1692

663

41.

AN EFFECTIVE CLINICAL PHARMACIST COMMUNICATION MAY BUILT PATIENT TRUST ON PHARMACIST OVER OTHER HEALTHCARE PROVIDERS: EVIDENCE BASED PRACTICE

Clinical pharmacists are integral part of patient healthcare team. They tend to serve as key element in patient care provide quality of care to reduce ADR (adverse drug reactions),improve patient compliance, effective drug cost and make role of  pharmacist evident in healthcare sector and society. For the purpose of evaluating patient outcome failure from treatment, a retrospective study conducte...

Maria Ayub*, Somia Gul, Nusrat Afzal and Asma Eraj

Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

DOI: 10.13040/IJPSR.0975-8232.6(10).4442-47

4442-47

1676

575

42.

BRASSICA OLERACEA: A POTENT ANTIOXIDANT THERAPEUTIC IN HEALTH AND DISEASES

Oxidative stress contributes towards initiation and progression of hepatic damage in a variety of liver disorders (e.g. Hepatitis C, Hepatitis B, non alcoholic fatty liver disease amongst others). Hence, there is a great demand for the development of agents with potent antioxidant effect. There are various plant derived products which act as antioxidants. The aim of the present investigation is to...

Komal Talreja and Archana Moon*

University Department of Biochemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4448-52

4448-52

1602

580

43.

METHOD DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR ASSAY DETERMINATION OF IMATINIB IN IMATINIB MESYLATE TABLETS DOSAGE FORM

A simple, rapid and isocratic reversed phase high performance liquid chromatographic (RP-HPLC) stability indicating method was developed and validated for the determination of Imatinib in tablet dosage form. Imatinib drug was exposed to several stress conditions. The proposed method proved to be stability indicating by forced degradation experiments and mass balance study. The chromatographic sepa...

Pratik Shah, Nisha Shah and Rutesh Shah*

K K Shah Jarodwala Maninagar Science College, Gujarat University, Ahmedabad, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4453-68

4453-68

2913

921

44.

FORMULATION AND CHARACTERIZATION OF DRUG IN ADHESIVE TRANSDERMAL PATCHES OF BUFLOMEDIL HYDROCHLORIDE

The purpose of this research was to develop a drug-in-adhesive type transdermal drug delivery system containing drug, buflomedil hydrochloride, pressure sensitive adhesive (PSA), Duro-Tak 387-2052 by the solvent evaporation technique. Different concentrations of penetration enhancers; oleic acid and isopropyl myristate (IPM) were used to enhance the transdermal permeation of buflomedil hydrochlori...

Farhat Mirza * and Alka Lohani

School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4469-77

4469-77

2241

826

45.

ASSESSMENT OF MEMBRANE STABILIZATION, ANTIOXIDANT AND THROMBOLYTIC POTENTIAL OF LUTEIN- AN IN-VITRO STUDY

Lutein; an orange-red colored powder, insoluble in water; is a member of the carotenoid family, a xanthophyll pigment. Lutein was evaluated for its antioxidant property when dissolved in different solvents. Solvents used in the study were chloroform, ethanol, methanol and dimethyl sulfoxide (DMSO). The antioxidant potential of lutein was evaluated by total antioxidant capacity, 2, 2’-diphenyl-1-...

V. Vidya , Yogish Somayaji T. , S. Pooja , Shrikant Patil, Ronald Fernandes and A. P. Krishna

Central Research Laboratory , KS Hegde Medical Academy, Nitte University, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4478-83

4478-83

1716

524

46.

AN IN SILICO APPROACH TO IDENTIFY NEW ANTI-HIV INTEGRASE INHIBITOR LIKE LEADS BY DOCKING STUDIES

The Human immunodeficiency virus(HIV)type-1 integrase is one of the most important target of highly active anti retrovirus therapy (HAART), due toits role to incorporate genetic information into the host DNA, so its prevention to its proper function results in very fine therapeutic effect for the treatment of all acquired immune deficiency syndrome(AIDS), extensive research work on integrase inhib...

Rituraj *, K. K. Srivastava , Shubha Srivastava and Tanweer Alam

Department of Chemistry, Vinoba Bhave University, Hazaribagh, Jharkhand, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4484-90

4484-90

1399

503

47.

T3 IS AS GOOD A POINTER OF CREATINE KINASE LEVELS IN EUTHYROIDS AS T4 IS IN HYPOTHYROIDS

Aim: Hypothyroidism is one of the commonest metabolic diseases which afflicts females more than males and is often associated with myopathy. Reports on relationship of muscle-markers with thyroid hormones in the (a) euthyroid population in general and (b) hypothyroid population in India are scarce. Materials and Methods: A randomized case-control study on the female population for which 60 hypothy...

S. Jyothi, S. Baliarsingh *, K. Pratibha, V. Vijayakumari, K. Nanda and M. Tejomani

Department of Biochemistry, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4491-95

4491-95

1574

479

48.

ANTINOCICEPTIVE AND GASTRO PROTECTIVE EFFECTS OF INHALED AND ORALLY ADMINISTERED THEVETIA PERUVIANA PERS. K. SCHUM. ESSENTIAL OIL

In Present study the antinociceptive and the gastroprotective effects of orally administered or inhaled Thevetia peruviana Pers. K. (Schum) (Oleander) volatile oil, and its principal constituents linalool and 1,8-cineole were evaluated in mice. Either when orally administered (100µl/kg) or inhaled for 60 min Thevetia peruviana volatile oil significantly reduced the acetic acid-writhing response i...

Pragati Kumar *, Prabodh Shukla , Padmini Shukla and Shashi Alok

Department of Pharmacognosy, NIMS Institute of Pharmacy, NIMS University Jaipur (R.J.), India

DOI: 10.13040/IJPSR.0975-8232.6(10).4496-02

4496-02

1676

614

49.

HYPERDENSE INTRACRANIAL VESSELS IN NON-CONTRAST COMPUTED TOMOGRAPHY SCAN OF BRAIN-A CASE REPORT

A 20-year-old male patient reported to ophthalmology outpatient department with complaint of loss of vision in right eye since childhood and diminished vision in left eye for 1month of duration. Funduscopy revealed right side optic atrophy and left sided vitreous hemorrhage. Non-contrast computed tomography study of head showed hyperdense circle of Willis and cerebral venous sinuses. No contrast w...

Ranjan Kumar Sahoo*, P Bahinipati, Suresh Kumar Behera and Niranjan Sahu

Department of Radio-diagnosis, IMS & SUM Hospital, Bhubaneswar, Odisha, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4503-05

4503-05

1807

504

50.

A CASE ON KAWASAKI SYNDOME IT’S DIAGNOSIS AND MANAGEMENT

Kawasaki Syndrome (KS) can be a widespread vasculitis affecting many systems, and some of the other recognized complications are discussed, including those affecting the skin, nervous system, gastrointestinal tract, musculo-skeletal system, kidneys, lungs, eyes and haematological effects. There is no specific diagnostic test or pathognomonic clinical features; those previously mentioned clinical c...

Apollojames*, K Chaitanya, Ch Jahnavi, Y Kanthikiran, TR Ashok Kumar and T Sivakumar

Department of Pharmacy Practice, Nandha College of Pharmacy, Erode, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4506-08

4506-08

1481

567

51.

ANTI-DIABETIC PROFILE OF CINNAMON POWDER EXTRACT IN EXPERIMENTAL DIABETIC ANIMALS

Objective: to investigate the anti diabetic effect of ethanolic extract of Cinnamomum zeylanicum on Alloxan induced diabetes in experimental animals (Rats). Materials and Methods:  the alcohol extract of Cinnamomum zeylanicum was tested for its efficacy in Alloxan (150mg/kg) induced diabetic rats. The diabetic rats were divided into 5groups. Group I (control) received 2% gumacasia, group II (posi...

Pusuloori Rajesh, S. Sharon Sonia. , Y. Vijayabhaskara Reddy and M. Shiva Kumar

Department of Pharmacology of Kurnool Medical College, Kurnool, A. P., India.

DOI: 10.13040/IJPSR.0975-8232.6(10).4509-13

4509-13

1479

533

52.

AVAILABILITY AND AFFORDABILITY OF ESSENTIAL ANTIBIOTICS FOR PEDIATRICS IN SEMI-RURAL AREAS IN TANZANIA

In this study, we assessed the availability, cost and affordability of essential antibiotics for paediatrics in a semi-rural region in Tanzania. Data were collected from 1 Medical Stores Department (MSD), 8 public hospitals, 30 Private Pharmacies and 30 Accredited Drug Dispensing Outlets (ADDO`s). The median price of tracer medicines and average stock-out days of per year were used to assess the c...

Appolinary A.R. Kamuhabwa* and Kabandika Twaha

Unit of Pharmacology and Therapeutics, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

DOI: 10.13040/IJPSR.0975-8232.6(10).4514-29

4514-28

1977

455

53.

ANTI-OXIDANT ANDANTI-CANCER POTENTIAL OF SYMPLOCOS RACEMOSA BARK AGAINST HEP3B CELL LINE

Objective: The aim of this study is to evaluate anti-oxidant and anticancer activity of methanol extract and ethyl acetate soluble fraction of methanol extract of Symplocos racemosa bark against the hepatocellular carcinoma. Materials and methods: DPPH and H2O2 free radical scavenging assay were tested for determining the anti-oxidant activity. Rat normal liver cells (BRL-3A) and human hepatocellu...

Niyati Acharya *, Unnati shah , Lal Hingorani and Sanjeev acharya

Department of Pharmacognosy, Institute of Pharmacy, Nirma University, Ahmedabad-382481, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.6(10).4529-33

4529-33

1891

679

54.

EVALUATING HYPOGLYCEMIC POTENTIAL OF KASNI (CICHORIUM INTYBUS) SEED PREPARATIONS IN TYPE 2 DIABETES MELLITUS PATIENTS

Objective: To evaluate hypoglycemic responses of Kasni (Cichorium intybus) seed preparations in combination with oral hypoglycemic agent in treatment of patients of newly diagnosed type2DM. Methods: Newly diagnosed 90 patients of type2DM, age 35-65years, of either sex were divided into 3 groups. Each group had 30 patients (19 male and 11 females) matched with each other in terms of age and sex. In...

Praveen Katiyar *, Amod Kumar , Arvind K, Mishra, Rakesh K. Dixit and Ajay K. Gupta

Department of Pharmacology & Therapeutics , King George's Medical University, Lucknow, U.P., India

DOI: 10.13040/IJPSR.0975-8232.6(10).4534-43

4534-43

2044

539