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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 8 (2017) - Issue 4, April

Review Articles

 
Title
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1.

BRONCHIAL ASTHMA: AN UNMET DISEASE

Asthma is a chronic obstructive disease of airways affecting bronchi, resulting in bronchoconstriction, tightening of chest and airway inflammation. Asthma remains a disease with clearly unsatisfactory therapeutics. With the mounting evidence in support of asthma being an inflammatory illness, anti-inflammatory agents have now become prerequisite for the long-term management of asthma. Along with ...

Rakesh Yadav * and Divya Gumber

Department of Pharmacy, Banasthali University, Banasthali, Tonk, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1514-21

1514-1521

3088

1585

2.

DALBERGIA SISSOO LINN. AN OVERVIEW MORPHOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGY

The present review is, therefore, an effort to give a detailed survey of the literature on its pharamacognosy, phytochemistry, traditional uses and pharmacological studies of the plant Dalbergia sissoo. The genus consists of 300 species among which 25 species occur in India. The generic name Dalbergia honors the Swedish brothers Nils and Carl Dalberg, who lived in the 18th century.  Dalbergia sis...

Rohit Kumar Bijauliya *, S. K. Jain, Shashi Alok, V.K. Dixit, Devender Singh and Man Singh

Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1522-33

1522-1533

4739

1715

3.

RESOLVIN AND LIPOXINS ENDUE UNVEILING ROLE IN MOA OF ASPIRIN: A REVIEW

Resolvins and lipoxins endue a novel way of approaching aspirin mechanism of action by developing models. Recent advances in research of aspirin from starting point Willow bark (Salix alba) to resolvins and lipoxins along with their repurposing network. Therefore, aspirin have a big impact on most interesting areas of research. Aspirin and there interaction with several targets molecules (Magic sh...

R. K. Mishra *, A. Mishra, C. P. Gupta, S. Alok, J. Haider and S. Srivastv

Department of Pharmacy, ITM, Gida Gorakhpur, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(4).1534-40

1534-1540

2737

1205

4.

APPLICATION OF SPRAY DRYING TECHNIQUE FOR PREPARATION AMORPHOUS SOLID DISPERSION

As time passes more and more poorly water soluble drug are being discovered. Formulating these drugs in to amorphous solid dispersion is an effective strategy to deliver poorly water soluble drugs. Spray drying is one of common and a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs). However, the spray drying is complex phenomenon and the sp...

B. N. Phapale * and A. P. Patil

Macleods Pharmaceuticals Ltd. , Shantinagar, Andheri (E), Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1541-49

1541-1549

2926

2547

5.

VARIOUS ANIMAL MODELS FOR PRECLINICAL TESTING OF ANTI-INFLAMMATORY AGENTS

Inflammation is the local defensive response of living tissues to injury or due to any other chemical agents. Inflammation consists of two basic processes early inflammatory response later followed by healing. There are two types of inflammation, acute and chronic. The different animal models (i.e. vascular permeability, UV-erythema in guinea pigs, Croton-oil ear edema in rats and mice, Paw edema ...

R. K. Sindhu *, N. Sood, V. Puri and S. Arora

Department of Pharmacognosy and Natural Products, Chitkara College of Pharmacy, Chitkara University, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1550-57

1550-1557

5301

1608

6.

LIFE CYCLE APPROACH TO CLEANING VALIDATION

The regulatory expectations are changing day by day on the cleaning validation in Pharmaceutical industries, considering the patient safety and drug efficacy. Manufacturing of an Intermediate and Active Ingredient Pharmaceuticals involves many chemical syntheses and same equipment is being using for manufacturing of different product in multi-production facility. Equipment cleaning plays a key rol...

Chandra Sekhar Gupta Penugonda

Quality Assurance, Dr. Reddy’s Laboratories Limited, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1558-70

1558-1570

6268

1522

7.

IMPORTANCE OF SR-B1 RECEPTOR IN CARCINOGENESIS AND TREATMENT: A REVIEW

Scavenger receptor class B member 1 also known as SR-B1 is a receptor that in human is encoded by the SCARB1 gene. SR-B1 functions as a receptor for high density lipoprotein. SR-B1 receptor is mostly found in liver and is best known for its role in facilitating the uptake of cholesteryl ester from HDL in liver. This movement of cholesterol is known as reverse cholesterol transport. Cancerous cells...

Y. S. Yadav*, A. K. Vishwakarma, V. K. Yadav, R. K. Yadav and P. Yadav

Department of Pharmacy, Prasad Institute of Technology, Dr. A.P.J. Abdul Kalam Technical University, Jaunpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1571-74

1571-1574

1443

425

Research Articles

 
Title
Views
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Cited
8.

NEW GALACTOSYLATED NSAIDs PRODRUGS IN A GREEN CONTEXT: SYNTHESIS AND STABILITY

Prodrug approach is a new frontier that reinforces the concept of green chemistry in the pharmaceutical chemistry field. The combination of a suitable synthesis and the strategy of the prodrug is of huge advantage for pharmaceutical industries. In this paper, we compare the conventional synthesis of new galactosylated NSAIDs prodrugs with green strategies and demonstrate how we can move away from ...

S. Magliocca *, F. Sodano, M. Nieddu, L. Burrai, G. Boatto and M. Grazia Rimoli

Department of Pharmacy 1, “Federico II” University of Naples, Naples, Italy

DOI: 10.13040/IJPSR.0975-8232.8(4).1575-81

1575-1581

2232

1078

9.

AMELIORATIVE EFFECT OF HELIX ASPERSA CRUDE EXTRACT AGAINST COLONIC DAMAGES INDUCED BY HYPERHOMOCYSTEINEMIA IN RATS

The present study was designed to evaluate the effect of Helix aspersa crude extract on colonic injury resulting from hyperhomocysteinemia induced by feeding rats high methionine diet. Wistar albino rats (200-250g) were divided into four groups. Hyperhomocysteinemia (Hhcy) was induced by methionine treatment (1g/kg/day) for 15 days. M group received only Methionine, MH and MP received Methionine a...

Souad Lamda*, Dalila Naimi, Cherifa Aggoun and Ouissem Hafdi

Ecole Nationale Superieure de Biotechnologie ENSB, Constantine, Algeria

DOI: 10.13040/IJPSR.0975-8232.8(4).1582-89

1582-1589

2165

1007

10.

THE EVALUATION OF SENSITIVITY AND SPECIFICITY OF NEW DEVELOPED 99M Tc- OFLOXACIN RADIOTRACER TO DISCRIMINATE INFECTION INDUCED BY STAPHYLOCOCCUS AUREUS AND STERILE INFLAMMATION INDUCED BY CARRAGEENAN IN RAT’S FOOT

The early identification of infection from sterile inflammation is still challenging step in nuclear medicine. Therefore, several radiopharmaceutical agents have been examined to find the solution of this dilemma in clinical practice. Recently 99mTc-Ofloxacin has been developed as an infection-seeking radiotracer. This investigation was launched to examine the sensitivity and selectivity of new de...

A. Doroudi *, A. Kiasat, M. Saadi, S. M. Saadati, F. Ahmadi, B. Etesami, Md. J. Khodayar and M. Erfani

School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

DOI: 10.13040/IJPSR.0975-8232.8(4).1590-97

1590-1597

1961

902

11.

SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY EVALUATION OF SOME NEW 2-(3-FLUOROBIPHENYL-4-YL) PROPANOIC ACID DERIVATIVES

Different new compounds derived from 2-(3-flourobiphenyl-4-yl) propanohydrazide [2] as starting material were synthesized. Reaction [2] with maleic anhydride, succinic anhydride and phthalic anhydride gave the corresponding cyclicimides [3a-c]. The hydrazone derivatives [4a-d] were obtained by condensation of compound [2] with 2,4-dimethoxybenzaldehyde, 4-(N,N-dimethylamino)benzaldehyde, 3-hydroxy...

Ahmed W. Naser *, Ahmed J. Al-Musawi, Ammar A. Fadhil and Nada N. Al-Shawi

Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq

DOI: 10.13040/IJPSR.0975-8232.8(4).1598-05

1598-1605

2290

1208

12.

ESSENTIAL OILS EFFECT IN COMBINATION WITH ANTIBIOTICS AGAINST STAPHYLOCOCCUS AUREUS ATCC 29213 BIOFILM SUSCEPTIBILITY

Staphylococcus aureus biofilm has been known as one inducing factor for the bacteria’s resistance to various antibiotics. One strategy which may increase the efficacy of the antibiotic is by combining the antibiotic therapy with antiinfective from natural resources. This research was evaluating the potency of three known antiinfective essential oil derived from leaves of Piper betle L., Ocimum b...

A. Andika, M. P. Mentari, M. C. Dewanti, T. Hertiani and SUT Pratiwi *

Department of Pharmaceutical Biology, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Sleman, Yogyakarta, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.8(4).1606-12

1606-1612

2227

825

13.

IMPROVING SOLUBILITY OF CURCUMIN IN AQUEOUS SYSTEM BY THE SELF-ASSEMBLY OF HYPERBRANCHED POLY(AMIDE-ESTER) AND CURCUMIN

In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. Flu...

Sujuan Wang *, Tongtong Li, Xixi Peng and Xinwu Ba *

College of Chemistry and Environmental Science, Hebei University, Baoding, P. R. China.

DOI: 10.13040/IJPSR.0975-8232.8(4).1613-18

1613-1618

2141

875

14.

ASSESSMENT OF URINARY 8-HYDROXYDEOXYGUANOSINE LEVEL IN DIABETIC CANCER PATIENTS

Both diabetes mellitus and cancer are characterised by higher levels of oxidative stress and production of free radicals, which further complicate the control and outcomes of these diseases.  The aim of this study was to assess the level of urinary 8-Hydroxydeoxyguanosine in diabetic cancer patients as a biomarker of cellular oxidative stress for both disease progression and chemotherapy administ...

A. Al-Taie *, F. V. Izzettin, M. Sancar, A. Köseoğlu, M. Aliustaoğlu and A. Kaptanağasi

Clinical Pharmacy Department, Faculty of Pharmacy, Marmara University, Istanbul, Turkey.

DOI: 10.13040/IJPSR.0975-8232.8(4).1619-23

1619-1623

1809

511

15.

PROBIOTICS MAY PROTECT DROSOPHILA FROM INFECTION BY ASPERGILLUS FLAVUS

Probiotics have been used to protect hosts from pathogens of gastrointestinal and reproductive systems, but their ability to protect against systemic pathogens is largely unexplored. In this study we ask whether orally administered bacteria and yeasts can protect Drosophila melanogaster against the opportunistic fungal pathogen Aspergillus flavus. Flies were fed an artificial diet mixed with live ...

LA Ramírez-Camejo*, M García-Alicea, G Maldonado-Morales and P Bayman

Department of Biology, University of Puerto Rico - Río Piedras, San Juan PR.

DOI: 10.13040/IJPSR.0975-8232.8(4).1624-32

1624-1632

2227

620

16.

ANTIMICROBIAL, CYTOTOXICTY AND ANTI CANCER ACTIVITY OF SILVER NANOPARTICLES FROM GLYCYRRHIZA GLABRA

In this study, the plant Glycyrrhiza glabra was explored for the synthesis of silver nanoparticles (SNPs). The SNPs were characterised by ultra-violet-visible spectroscopy, FTIR analysis and scanning electron microscopy. SEM analysis revealed the formation of SNPs of average size of 46 nm with aqueous extract of G. glabra. The SNPs synthesised by aqueous extract of G. glabra showed strong antibact...

N. Pandian and Soundhari Chidambaram *

Department of Microbiology, Valliammal College for Women, Chennai, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1633-41

1633-1641

2462

655

17.

FORMULATION AND EVALUATION OF NANOSUSPENSION TO IMPROVE SOLUBILITY AND DISSOLUTION OF DIACEREIN

Diacerein is an Osteoarthritic drug that exhibited suboptimal oral bioavailability upon oral administration of conventional dosage form. Nanosuspension gaining more attention for improving oral bioavailability of such drugs. This study was aimed to enhance the solubility and dissolution of diacerein by preparing Nanosuspension. Diacerein Nanosuspension was prepared using combination of High Speed ...

Khyati Kamleshkumar Parekh *, Jalpa Shantilal Paun and Moinnudin M. Soniwala

Department of Pharmaceutics, Smt. C.V. Gajera Pharmacy Mahila College, Amreli, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1643-53

1643-1653

4013

918

18.

PHYTOCHEMISTRY, ANTI-CANCER AND ANTI-INFLAMMATORY ACTIVITIES OF SOLVENT LEAF EXTRACTS OF NYCTANTHES ARBOR – TRISTIS

Ayurveda is one of the oldest systems of medicine that uses plants and their extracts for treatment and management of various diseased states. Nyctanthes arbour - tristis Linn. (Family Oleaceae), which has long been used traditionally for various medicinal purposes in the Indian sub continent. Each part of the plant has some important medicinal value and is thus commercially exploitable. It is now...

T. D. Sandhya Kumari and M. A. Singara Charya *

Department of Microbiology, Kakatiya University, Warangal, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.8(4).1654-63

1654-1663

2553

651

19.

A COMPARATIVE STUDY OF MYO INOSITOL VERSUS METFORMIN ON BIOCHEMICAL PROFILE IN POLYCYSTIC OVARIAN SYNDROME IN WOMEN

Objective: PCOS is a common endocrine disorder in women of reproductive age associated with insulin resistance. Metformin and Myo-inositol being insulin sensitizers improve biochemical parameters. This study was done to compare the effects of these drugs on biochemical profile in PCOS. Material and Methods: A prospective, open labeled, randomized, comparative, clinical study was conducted on 60 pa...

J. Nehra *, J. Kaushal, S. Rani Singhal and V. Singh Ghalaut

Department of Pharmacology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1664-70

1664-1670

5833

866

20.

PREPARATION AND CHARACTERIZATION OF pH/TEMPERATURE SENSITIVE MICROCAPSULES BY INVERSE EMULSION POLYMERIZATION

The pH/temperature sensitive microcapsules were prepared by inverse emulsion polymerization, in which sodium alginate (SA) and N-isopropyl acrylamide (NIPAm) were used as the wall material and pentoxifylline as a model drug. The effects of the emulsifier content on the particle size distribution and drug release property of microcapsules were discussed in detail. The structure, morphology, particl...

Jinfang Wang, Haiyang Cui and Puying An *

College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei, PR China.

DOI: 10.13040/IJPSR.0975-8232.8(4).1671-76

1671-1676

1941

502

21.

DOCKING STUDIES OF BENZIMIDAZOLE DERIVATIVES USING HEX 8.0

N-mannich bases of benzimidazole derivatives can work against convulsions. Docking used for virtual screening of database and for the prediction of the strongest binders based on various scoring functions. Docking studies were carried out on different benzimidazole derivaties for better anticonvulsant activity which is important for the development of new class of inhibitors. Protein–ligand inte...

M. Sai Harika *, T. Raj Kumar and L. Siva Sankar Reddy

Department of Pharmaceutical Chemistry, Creative Educational Society’s College of Pharmacy, Chinnatekur, Kurnool, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1677-88

1677-1688

2222

632

22.

EVALUATION OF PHYTOCHEMICAL, ANTIOXDATIVE AND ANTIMICROBIAL EFFECT OF MAGNIFERA INDICA, LEAF EXTRACTS ON ORAL DENTAL PATHOGENS

A major part of the total population in developing countries still uses traditional folk medicine obtained from plant resources. Chemical substances used for prevention of dental caries are known to have many side-effects. Thus, natural products should be explored for their anticaries action. Present study evaluate the antimicrobial effect of alcoholic and aqueous extracts of Magnifera indica leav...

Deepa Garg * and Nikhil Mohanan

School of Biotechnology and Bioinformatics, D. Y. Patil University, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1689-93

1689-1693

2128

676

23.

NEUROPROTECTIVE EFFECTS OF OCIMUM SANCTUM, LINN. EXTRACT ON MPTP-INDUCED OXIDATIVE AND NITROSATIVE STRESS MARKERS IN MALE MOUSE BRAIN

The present study focuses on the ‘antioxidant approach’ as a therapeutic intervention for Parkinson’s disease (PD). It deals with understanding of the effects of Ocimum sanctum extract on oxidative and nitrosative stress biomarkers, responsible for neurodegeneration. The standardized hydromethanolic extract of O.sanctum, Linn (Os HM) at the dose of 50, 100 and 200 mg/kg were evaluated for th...

R. G. Redkar, V. V. Peshattiwar and S. Sathaye *

Pharmacology Research Laboratory-II, Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology (ICT), Nathalal Parekh Marg, Matunga-East, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1694-00

1694-1700

1735

481

24.

ANTI-OXIDANT POTENTIAL OF METHANOLIC EXTRACT OF TRIGONELLA FOENUM, TRACHYSPERMUM COPTICUM, NIGELLA SATIVA AND THEIR COMBINATION IN 1:1:1 RATIO

Trigonella foenum (T. foenum), Trachyspermum copticum (T. copticum) and Nigella sativa (N. sativa) are important medicinal plants that need to be explored for their anti-oxidant potential. The aim of the present study was to evaluate the total anti-oxidant potential of methanolic extracts of T. foenum, T. copticum, N. sativa and the combination of these methanolic extracts in 1:1:1 ratio (Combinat...

D. Vathalani, V. V. Peshattiwar and S. Sathaye *

Pharmacology Research Laboratory-II, Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology (ICT), Matunga-East, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1701-07

1701-1707

1628

559

25.

DESIGN OF EXPERIMENT UTILIZATION TO DEVELOP AND VALIDATE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY TECHNIQUE FOR ESTIMATION OF PURE DRUG AND MARKETED FORMULATIONS OF ATORVASTATIN IN SPIKED RAT PLASMA SAMPLES

A novel method of estimation and validation of Atorvastatin by Reverse Phase-High Performance Liquid Chromatography coupled with Ultra-violet detection was developed which had high potential in determining drug concentration in rat plasma samples during preclinical studies. Atorvastatin being >99% protein bound, exhibits great challenge in getting extracted from plasma samples. Hence, by treati...

M. Mathur and V. Kusum Devi *

Department of Pharmaceutics, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur road, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1708-16

1708-1716

1421

425

26.

EVALUATION OF ANTIANAPHYLACTIC ACTIVITY OF VARIOUS EXTRACTS OF WITHANIA SOMNIFERA IN RATS

Antianaphylactic activity of Withania somnifera was investigated by using rat peritoneal mast cells. The investigation was carried out by presensitization of the rat by using sheep serum and tripple antigen. Sensitization induces mast cell degranulation. The rats which were pretreated with standard drug, prednisolone (10 mg) and different extracts (petroleum ether, methanol and aqueous extract) of...

C. Girish and Y. Narsimha Reddy *

Department of Pharmacology, University College of Pharmaceutical sciences, Kakatiya University, Warangal, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1717-22

1717-1722

1623

490

27.

MOLYBDENUM BLUE METHOD FOR THE SPECTROPHOTOMETRIC DETERMINATION OF LEVETIRACETAM- CALCIUM CHANNEL MODULATOR

A simple, accurate, precise and easy spectrophotometric method for the determination of levetiracetam in pharmaceutical formulations using molybdenum blue method was developed by the authors. Aqueous solution of the drug sample on reaction with ammonium molybdate solution and hydrazine sulphate solution on heating for 5 minutes at a temperature of 60 0 C gave a clear, stable and intense blue color...

G. V. S. R. Pavan Kumar *, K. Srinivasa Rao, Yerra Bharath and M. Komal Avinash

Department of Chemistry, MVGR College of Engineering, Vijayramnagar campus, Chintalavalasa, Vizianagaarm - 535002, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(4).1723-26

1723-1726

1936

578

28.

EFFECT OF AGE AND SEX UNDER IMATINIB MESYLATE THERAPY ON CHRONIC MYELOID LEUKAEMIA PATIENTS: A PILOT STUDY FROM INDIA

Among adults in India, Chronic myeloid leukemia (CML) is most common leukemia and accounts for 30% to 60% of all adult leukemias. Imatinib mesylate induces the highest rate of complete hematological and cytogenetic responses, but its efficacy is still debated in different sets of patients. Total 50 newly diagnosed patients of CML were enrolled. Patients receiving imatinib 400mg orally daily were m...

M. Singh, A. K. Gupta, J. K. Singh, M. K. Rastogi, P. Das, K. Pandey and A. Nath *

National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Bihar, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1727-33

1727-1733

2120

499

29.

HPLC METHOD FOR ESTIMATION OF DRUG RELEASE OF ENTACAPONE IN ENTACAPONE, LEVODOPA AND CARBIDOPA TABLETS

Today’s generic drugs manufacturing industry need robust analytical methods for analysis of generic drug products to provide best quality pharmaceutical formulation. Entacapone, Levodopa and Carbidopa tablets is such a product which is used for the treatment of Parkinson’s disease.  This paper presents a robust HPLC method that has been developed for estimation of % drug release of Entacapone...

Prasoon Bhatnagar*, Deepak Vyas, Shailendra Kumar Sinha and Archana Gajbhiye

Research Scholar, Department of Chemistry, Sir Padampat Singhania University, Bhatewar, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(4). 1734-43

1734-1743

2100

481

30.

EVALUATION OF PROMOTIONAL DRUG LITERATURE PROVIDED BY MEDICAL REPRESENTATIVE AT A TERTIARY CARE HOSPITAL

Objectives: The study was aimed to evaluate and analyse the drug promotional literature distributed by pharmaceutical companies to physicians. This was done using World Health Organization (WHO) criteria for ethical medicinal drug promotion and International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) Code of Practice, 2012.  Detailed analysis of claims was done. Materia...

Kothari Parli, Raval Reema, Rana Devang and Malhotra Supriya *

Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1744-50

1744-1750

2113

574

31.

COMPARATIVE STUDY ON PHARMACOGNOSTIC AND PHYTOCHEMICAL COMPOSITION OF SEED COAT AND COTYLEDON OF CAJANUS CAJAN L.

Cjanus cajan (L.) Millsp belonging to the family Fabaceae commonly known as pigeonpea or arhar. The present study conducted to assess the   phytochemical and pharmacognostic in terms of organoleptic, fluorescence analysis and physicochemical parameters of seed coat and cotyledon of C. cajan. Differential extraction yielded of seed coat extracts of petether, chloroform, ethanol and aqueous shows ...

H. Pratima * and Pratima Mathad

Department of Post-Graduate Studies and Research in Botany, Karnataka State Women’s University, Vijayapur - 568101, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1751-57

1751-1757

2014

548

32.

ASSESSMENT OF ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL SCREENING OF COLOCASIA ESCULENTA CORM

Colocasia esculenta corm aqueous extract was assessed for its in vitro antioxidant capacity and free radical scavenging potential by seven different assays, viz. total phenolic content, total flavonoid content, total flavonol content, reducing power estimation as well as 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radic...

Manjulika Yadav, Devesh Kumar Kushawaha, Sanjukta Chatterji and Geeta Watal *

Alternative Therapeutic Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1758-64

1758-1764

3253

625

33.

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF BUCOADHESIVE TABLET OF CHLORPHENIRAMINE MALEATE AND PHENYLEPHRINE HYDROCHLORIDE IN COMBINED DOSAGE FORM

Delivery of the desired drug as bioadhesive drug delivery systems has been subject of interest since 1980s. The various advantages associated with these systems made the buccal drug delivery as a novel route of drug administration. Buccal region offers an attractive route for the administration of systemic drug delivery. The objective of the study was to develop bucoadhesive buccal tablets of Chlo...

Prabhat Dessai * and Ankita S. Sawant

Postgraduate Chemistry Department, Dnyanprassarak Mandal`s College and Research Centre, Assagao-Bardez, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1765-75

1765-1775

2418

537

34.

ANTIOXIDANT ACTIVITIES OF LEAF EXTRACTS OF SOME COMMON BETEL VARIETIES (PIPER BETLE L.) AVAILABLE IN ODISHA

Natural antioxidants play an important role in the prevention of many age-related diseases and promotion of health. Among natural antioxidants from plants, flavonoids and other phenolic compounds are potent antioxidants and chelating agents. Betel (Piper betle) is the leaf of a vine belonging to the family Piperaceae, which also includes pepper and kava. It is valued both as mild stimulant and ap...

Manoj Kumar Kar, Sanjeet Kumar and Padan Kumar Jena *

Ravenshaw University, Cuttack, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1776-80

1776-1780

4415

487

35.

ARTOCARPUS METHANOL EXTRACT SEED OILS – A COMPARATIVE STUDY

In recent years, the significance of polyunsaturated fatty acids analysis has gained much attention because of their various biological activities in health and disease, especially the n-3 and n-6 fatty acids. The current proportional cram endeavors on providing qualitatively the fatty acid composition of methanol extracted seed oils of five Artocarpus species specifically Artocarpus heterophyllus...

Sirisha Nagala * and Raghava Rao Tamanam

Department of Biochemistry, College of Science and Technology, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1781-89

1781-1789

1684

883

36.

SCIENTIFIC VALIDATION ON SIDDHA PURIFICATION PROCESS OF NABHI

Suddhi is a unique process of detoxification which is employed topotentiate as well as enhance therapeutic properties the effect of raw drugs. Nabhi (Aconitum ferox), a herbal poisonous rhizome commonly known as aconitum is used extensively in various Siddha formulations, with great therapeutic significance. Siddha system recommends the administration of Nabhi only after suddhi (purification) in...

V. C. Jiji Mol * and P. Shanmugapriya

Department of Nanjunool, National Institute of Siddha Chennai, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1790-95

1790-1795

2704

738

37.

A COMPARATIVE GROUP-QSAR AND MOLECULAR DOCKING STUDIES OF 4 -THIAZOLIDINONE CONTAINING INDOLIN-2-ONE MOIETY AS VGEFR INHIBITORS

Vascular endothelial growth factor receptors (VEGFR) are kinase based receptors reported as a promising target in anti tumour therapy. VGEFR inhibitors are being investigated which can have important contribution in anti-angiogenic therapy for treatment of cancer. In the present study, an attempt has been made to develop a site-specific QSAR model in order to explore the definite sites of substitu...

Pragya Nayak * and Monica Kachroo

Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1796-05

1796-1805

1510

610

38.

ANTIDIABETIC EFFECT OF PLUMERIA RUBRA LINN. IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Diabetes is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased responsiveness of the organs to secreted insulin. The protective effect of aqueous extract of Plumeria Rubra was studied against streptozotocin (STZ) induced diabetes in rats. Plumeria rubra was administered orally at 3 dose levels (100, 200, 400mg/kg). Plumeria rubra extract and standard...

A. V. Yadav and V. R. Undale *

Allana College of Pharmacy, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1806-12

1806-1812

1968

469

39.

FORMULATION AND IN VITRO EVALUATION OF GASTRORETENTIVE FLOATING DRUG DELIVERY OF VALSARTAN USING HOT MELT EXTRUSION TECHNIQUE

The aim of present study is to improve the aqueous solubility of valsartan by utilizing hot melt extrusion technique (HME). Hot melt extrudates were prepared by novel polymeric matrices such as HPMCAS and Plasdone S630 copovidone at different ratios. The solubility studies of extrudates, showed a significant improvement in aqueous solubility. Gastroretentive floating tablets of valsartan using its...

Sandhya Pamu *, C V S Subrahmanyam , K S K Rao Patnaik

Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana State, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1813-19

1813-1819

1802

554

40.

IN-VITRO STUDY OF AMLODIPINE AND NIFEDIPINE DRUGS OF PULSATILE DRUG DELIVERY SYSTEM

To develop pulsatile microspheres of amlodipine and nifedipine drug release, a blend of polymer and solvent were used with pulsatile principles of drug delivery system to modified drug release pattern on and to release the drug at a particular time on the basis of lag time. In this study, we assessed the in vitro drug release pattern of the formulation prepared from different polymers ratio with t...

Rahul Taneja and Ghanshyam Das Gupta *

Department of Pharmaceutical Research Division, ASBASJSM College of Pharmacy, Bela (Ropar) Affiliated to I.K.Gujral Punjab Technical University, Jalandhar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1820-25

1820-1825

1955

445

41.

THE EFFECT OF GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) ON LITHIUM-INDUCED LOCOMOTOR ACTIVITY IN RAT

Ginger has shown to benefit in muscular pain due to eccentric exercise and in osteoarthritis but a later review denied these properties due to uncertainties. To ascertain the reality, this study was proposed. Methods: (A) Albino rats (n=6-12) were administered G.J at single dose (4 ml/rat, p.o) as single administration (acute) and chronic treatment 4ml/rat p.o over period of 7 days. Following this...

S. S. Prasad *, R. R. Pathak, S. K. Vajpeyee and V. H. Bhavsar

Department of Pharmacology, GMERS Medical College, Himmatnagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1826-29

1826-1829

1652

410

42.

NILGIRI RHODODENDRON: A HIGH ALTITUDE MEDICINAL TREE EXPLORED FOR ITS ANTIMICROBIAL ACTIVITY

The confined reports on Rhododendron arboreum Sm spp. nilagiricum (Zenker) Tagg stimulated to examine the bioactive compounds and the antimicrobial activity of its flower and bark extracts against medically critical human pathogenic microbes, apart from the availability of several reports on its main species R. arboreum. The microbial strains used for the study were four bacterial (Streptococcus p...

D. Saranya * and R. Ravi

PG and Research Department of Botany, Government Arts College, Ooty, The Nilgiris, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1830-35

1830-1835

1790

448

43.

COMPARATIVE EFFECTIVENESS OF SIMULATION BASED TEACHING VERSUS CONVENTIONAL TEACHING FOR UNDERGRADUATE STUDENTS OF SECOND PROFESSIONAL M.B.B.S IN EXPERIMENTAL PHARMACOLOGY

Aims: To evaluate and analyze effectiveness of animal simulation based teaching in pharmacology in comparison to conventional methods to undergraduate medical students. Methods: An interventional and comparative study was conducted among second professional MBBS students. All students were divided into two groups A and B. Four demonstrations of experimental pharmacology were demonstrated by conven...

Meena Atray, Apruva Agrawal and Deepika Atray *

Department of Microbiology, R.N.T. Medical College, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1836-41

1836-1841

1370

529

44.

ALLOPURINOL INDUCED TOXIC EPIDERMAL NECROLYSIS

Adverse drug reactions in the form of toxic epidermal necrolysis is a rare but potentially fatal disorder. The pathophysiology of such reactions are not properly understood. There are many drugs which are very often implicated for causing such severe reactions. Allopurinol is a common drug used in chronic gout but also notorious for causing Steven - Johnson syndrome and rarely toxic epidermal necr...

Bidyut Banerjee * and Suvan Kanti Chowdhury

Department of Pharmacology, Gauhati Medical College, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1842-45

1842-1845

2120

476

45.

COMPARISON OF POST PRANDIAL LIPID PROFILE AT AN INTERVAL OF 2 HOURS AND 4 HOURS IN PATIENTS OF CORONARY HEART DISEASE

Coronary heart disease (CHD) is widely prevalent both in the developed and developing countries and continues to be a leading cause of mortality despite recent advances in diagnostic facilities and treatment modalities. Recently it has been proposed that postprandial lipoprotein may be a better indicators of deranged lipoproteins metabolism and hence of atherosclerosis and CHD. The levels of non-f...

S. Ayyappan *, A. Kalyananibehra and T. Ilanchezhian

Department of Biochemistry, Vivekananda Dental College for Women, Tiruchengode, Namakkal District, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1846-49

1846-1849

1967

462

46.

EVALUATION OF ANALGESIC ACTIVITY OF AQUEOUS EXTRACT OF ALOE VERA [AEAV] IN ALBINO WISTAR RATS

Aloe vera has been used since ages to manage a number of diseases causing pain, inflammation and fever. However, its effectiveness has not been scientifically certified. NSAIDs & Opioid are used continuously for the pain management. Alternative analgesics are needed to escape from the serious adverse effects of NSAIDs. Our study demonstrated significant analgesic activity of Aloe vera at doses...

Devarsi Choudhury *, Bikash Gairola, Dolly Roy and Pavel Sikidar

Department of Pharmacology, Silchar Medical College and Hospital, Silchar, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1850-57

1850-1857

2063

505

47.

CURRY LEAF POWDER AND CUCUMBER SLICES ATTENUATE HYPERLIPIDEMIA IN POST MENOPAUSAL WOMEN: A RANDOMIZED CONTROL SINGLE BLINDED STUDY

Background: Woman's risk for developing heart disease rises after menopause may possibly correlated with the striking increase in cholesterol levels. Objective: A randomized controlled cluster group single blind study was conducted by treating with dried curry leaf powder and cucumber slices in hyperlipidemic post menopausal women in rural area. Methods:  Menopausal healthy women of rural communi...

J. Molly *, S. Edison, R Vijajaraghavan and T. Ananthanarayanan Ajith

Department of Research, Saveetha University, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1858-64

1858-1864

1520

417

48.

MACROSCOPICAL, MICROSCOPICAL AND PHYSICO-CHEMICAL STUDIES ON LEAVES OF DALBERGIA SISSOO LINN. (FABACEAE)

Objective: To rationalize the macroscopial, anatomical and physico-chemical studies on leaves of plant Dalbergia sissoo Linn. (Fabaceae). Methods: The crude ethanolic extract of leaves of Dalbergia sissoo Linn. (Fabaceae) was using physico-chemical parameters, fluorescence analysis, and preliminary phytochemical investigation (TLC, HPTLC, column chromatography). Results: An attempt has been made t...

Rohit Kumar Bijauliya *, S. K. Jain, Shashi Alok, V.K. Dixit and Vijay Kumar Singh and Man Singh

Institute of Pharmacy Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(4).1865-73

1865-1873

2026

604

49.

COMPARATIVE EVALUATION OF ANTIMICROBIAL ACTIVITY OF DIFFERENT PARTS OF ABELMOSCHUS MOSCHATUS AGAINST MULTI-RESISTANT PATHOGENS

Now a day the exposure of multi-resistance human pathogens has challenged our existing defense to save human being. To minimize such alarming issue, identification of naturally-occurring antimicrobial agents from plant origin has become a realistic and powerful tool to the researchers. Therefore the aim of this study was to investigate the antimicrobial potential of the ethanolic extracts of diffe...

M. M. Rahman, M. N. Haque, S. Hosen , J. Akhter , U.S.B. Kamal , E. N. Jahan, ASM S. Hossain, M. N. Uddin, M. B. Islam, M. R. Islam, AHM K. Alam and A. Mosaddik

Department of Pharmacy, University of Rajshahi, Rajshahi - 6205, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.8(4).1874-80

1874-1880

1935

576

50.

SELF‑MEDICATION AMONG UNDERGRADUATE MEDICAL STUDENTS IN TWO UNIVERSITIES IN SYRIA

Self-medication is the selection and use of medicines by individuals to treat self-recognized illnesses or symptoms. Studies performed on self-medication reveal that it is a fairly common practice, especially in economically deprived communities. This Descriptive cross sectional study assessed the self‑medication issue among medical students of Aleppo Government University (AGU) and Al-Andalus P...

M. F. Haroun and R. S. Al-kayali *

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Aleppo University, Syria.

DOI: 10.13040/IJPSR.0975-8232.8(4).1881-86

1881-1886

2557

475

51.

STUDY ON DETECTION METHODS FOR NOREPINEPHRINE IN BIOLOGICAL SAMPLES

Norepinephrine (NE) is an important catecholamine neurotransmitter that acts as a biochemical messenger in central nervous systems and neuronal cells of mammals, which is secreted and released by the adrenal medulla and the noradrenergic neurons during the synaptic transmission. It is often used for treating bronchial asthma, myocardial infarction hypertension and organic heart disease. Abnormal r...

Pei Zheng and Rong Xue *

Department of Neurology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin - 300052, PR China

DOI: 10.13040/IJPSR.0975-8232.8(4).1887-91

1887-1891

1578

406