Pages Menu
TwitterRssFacebook
ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

Categories Menu

Volume 11 (2020) - Issue 2, February

Review Articles

 
Title
Views
PDF
Cited
1.

THE ANTI-INFLAMMATORY ACTIVITY OF PLANT DERIVED INGREDIENTS: AN ANALYTICAL REVIEW

Inflammation, a protective response, can be dangerous if left untreated. The current synthetic anti-inflammatory drugs available in the market are coupled with various side effects. Plant-derived products can serve as a better alternative being cheap, easily available and having very few side effects. A sizable number of plants having anti-inflammatory activity have been studied. The crude extract...

D. Sarkar

Department of Zoology, A.P.C. Roy Government College, Himanchal Vihar, Matigara, Siliguri, Darjeeling, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).496-06

496-506

742

543

2.

DENDRIMERS FOR DRUG SOLUBILITY ENHANCEMENT– A REVIEW

Sufficient fluid solvency has been one in everything about required properties while choosing drug particles and completely uncommon bio-actives for advancement. Here and there dissolvability of a medication decides its pharmaceutical and remedial execution. Most of these days organized medicine IOTAS miss the mark or are rejected for the length of the main times of drug disclosure and improvement...

M. A. H. Malek and P. M. Patel *

Industrial Chemistry Department, V. P. and R. P. T. P Science College, Vallabh Vidyanagar, Anand, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).507-23

507-523

496

238

3.

MICROSPONGES: AS A TOPICAL DRUG DELIVERY SYSTEM

Now a day’s control delivery of the drug is easily achieved by Microsponge delivery system. These microsponges are very similar to polymeric porous microspheres. In general microsponges are 5-300 micron in diameter, spherical in shape, large porous surface, tiny in structures. Microsponges generally used in the topical drug delivery system but recently they are used for oral administration of dr...

S. Sharma *, A. Sharma and C. Kaur

Department of Pharmaceutics, Pharmaceutical Research Division, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, BELA (Ropar), Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).524-34

524-534

511

220

4.

HAEMOVIGILANCE: STEPPING STONE TOWARDS BLOOD SAFETY- INDIAN SCENARIO

Blood transfusion is an important part of various treatment protocols. Blood should be transfused with certain precautions like drug because blood and its constituents have the propensity to cause effects like introduction of donor antigens within the recipient, transfusion reactions or exposure to numerous transfusion-transmitted diseases. Thereby, it is important for the clinicians to remember t...

P. P. Anagha and S. Ponnusankar *

Department of Pharmacy Practice, JSS College of Pharmacy, Ooty, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).535-45

535-545

406

174

5.

A REVIEW ON NATURAL CHALCONES AN UPDATE

Plants are a valuable source of secondary metabolites. Many phytochemicals are obtained from the plant sources that are used as valuable medicinal agents. Chalcones are one of the important secondary metabolites obtained from many edible plants like foods, vegetables, tea, spices and natural foodstuffs. Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumu...

R. K. Banoth * and A. Thatikonda

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).546-55

546-555

474

177

6.

COMPREHENSIVE ETHNOPHARMACOLOGICAL REVIEW OF RUDANTI (CAPPARIS MOONII WIGHT)

Capparis moonii wight is a large woody climber or shrub (locally known as Rudanti) having Rasayana (rejuvenating) actions and it is being used in respiratory diseases like cough, bronchial asthma and pulmonary tuberculosis by ayurvedic physicians. It is one of the drugs which have references for its use from centuries but still not much explored in this contemporary era. The review aims to provide...

L. Nagar *, R. Lamo and K. N. Dwivedi

Department of Dravyaguna, Faculty of Ayurveda IMS, BHU, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).556-62

556-562

188

68

7.

APPLICATIONS OF CE-MS IN PHARMACEUTICAL FIELD

Capillary Electrophoresis–Mass Spectroscopy (CE-MS) is a hyphenated technique as it combines the advantages of both CE and MS. It provides high-resolution separations with high detection selectivity and sensitivity, which allows detailed characterization of many biomolecules in a single analysis. CE-MS improves the ability to deal with the analysis of complex biological samples containing trace ...

K. Bhavyasri * and G. Mounika

Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).563-72

563-572

166

77

8.

AN OVERVIEW ON TECHNOLOGY TRANSFER OF PHARMACEUTICAL INDUSTRY

The purpose of this review article is to discuss in detail about technology transfer in the pharmaceutical industry. The article highlights the objective, reasons for undergoing technology transfer, factors which affect technology transfer, steps involved in technology transfer process. Clearly explains the technology transfer documentation part this is an attempt to understand the aspects related...

S. Shalini *, K. Nijanthan, B. Rajkumar, S. Muthukumar, C. Sankar and G. Arulkumaran

Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).573-79

573-579

163

67

9.

HERBAL DRUGS IN BENIGN PROSTRATE HYPERPLASIA (BPH). A CURRENT UPDATE

Introduction: Benign prostatic hyperplasia (BPH) is a common age-related burden of males and found in more than 40% of men in their fifties. In Ayurveda, Vatasthila and Mutragranthi are condition mentioned under Mutraghata much resembles obstructive uropathy due to BPH. In modern medicine, management of benign prostatic hyperplasia (BPH) is either by surgical approach or by hormonal therapy and al...

V. Saxena, N. Srivastava * and N. Pandey

Department of Kaumarbhritya-Bal/ roga, Sardar Patel Institute of Ayurvedic Medical Sciences and Research Centre, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).580-86

580-586

203

65

10.

THE ROLE OF ANTIOXIDANTS AND THEIR RELATED ENZYME IN PROTECTIVE RESPONSE TO CEREBRAL ISCHEMIA REPERFUSION INJURY

In aerobic organisms, oxygen is essential for sufficient energy production but self-contradictory, produces chronic toxic stress in cells. So, protective techniques must exist for removal of toxic free radicals which are byproducts of oxygen. Diverse protective systems have evolved to enable adaptation of antioxidant activity. Tissues and organs have different rates of metabolic activity and oxyge...

O. Prabhakar * and P. Sancheti

Department of Pharmacology, GITAM Institute of Pharmacy, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh India.

DOI: 10.13040/IJPSR.0975-8232.11(2).587-98

587-598

185

68

11.

COENZYME Q10: A POTENTIAL BREAKTHROUGH IN PHYSIOLOGICAL DYSFUNCTIONS

Coenzyme Q10 (ubiquinone) is a lipophilic benzoquinone substance. It is a pivotal component to the oxidative phosphorylation in the inner mitochondrial membrane of all aerobic cells as well as diminishes reactive oxygen species (ROS). Exogenous sources for CoQ10 are grapes seed oil, walnuts, pistachios, spinach, and sesame seed. At present, it is being utilized as an antioxidant agent. Recent stud...

J. K. Gupta * and S. Giri

Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).599-04

599-604

250

78

Research Articles

 
Title
Views
PDF
Cited
12.

IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF PITURANTHOS CHLORANTHUS AND ARTEMISIA VULGARIS FROM TUNISIA

Pituranthos chloranthus and Artemisia vulgaris L. are two of the most important aromatic and medicinal species from the Apiaceae and Asteraceae families, respectively. They are traditionally used in certain pathologies in which inflammatory processes are involved. The present study investigates the potential of aqueous extracts of Tunisian P. chloranthus and A. vulgaris as a natural alternative so...

S. B. Nasr, S. Aazza, W. Mnif and M. G. Miguel *

Faculdade de Ciências e Tecnologia, Departamento de Química e Farmácia, Universidade do Algarve, Edifício 8, Centro para os Recursos Biológicos e Alimentos Mediterrânicos (MeditBio), Campus de Gambelas, Faro, Portugal.

DOI: 10.13040/IJPSR.0975-8232.11(2).605-14

605-614

480

277

13.

ESTIMATION OF SOME HEAVY METALS BIOACCUMULATION IN TISSUES OF THE INTESTINAL CESTODA POSTGANGESIA ARMATA AND ITS DEFINITIVE HOST; THE EUROPEAN CATFISH SILURUS GLANIS (L.) FROM TIGRIS RIVER PASSING THROUGH NORTHERN N. GOVERNORATE, IRAQ

Objective: The purpose of the study is to pursue some heavy metals in the aqueous environment of Tigris river that passes through Mosul city prior to the bioaccumulation of such metals in catfish Silurus glanis and its intestinal tapeworm Postgangesia armata. Methods: Silurus glanis, a freshwater fish were hunted from Tigris river passing through Al-Rashidiya region/Nineveh Governorate, North Iraq...

B. H. Al-Niaeemi *, M. H. Dawood, S. N. Al-Kallak and R. H. Ibrahim

Department of Basic Nursing Science, College of Nursing, University of Mosul, Iraq.

DOI: 10.13040/IJPSR.0975-8232.11(2).615-22

615-622

458

146

14.

FORMULATION AND EVALUATION OF NIOSOMES ENCAPSULATED WITH KT2 AND RT2: ANTIMICROBIAL AND ANTICANCER PEPTIDES DERIVED FROM CROCODILE LEUKOCYTE EXTRACT

Niosome is one of the synthetic nanoparticles which often is used for drug delivery and cosmetic industry. The aim of this study was to prepare niosomes encapsulated with KT2 and RT2. KT2 and RT2 are antimicrobial and anticancer peptides derived from crocodile leukocyte extract. Niosomes encapsulated with KT2 and RT2 were prepared by thin-film hydration technique, and peptide encapsulation efficie...

T. Theansungnoen *, J. Daduang, A. Priprem, P. Boonsiri, S. Daduang and S. Klaynongsruang

Green Cosmetic Technology Research Group, School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, Thailand.

DOI: 10.13040/IJPSR.0975-8232.11(2).623-30

623-630

427

176

15.

CONFIRMATION OF LARGE LEAF GENTIAN (GENTIANA MACROPHYLLA PALL.) IDENTITY BY THIN-LAYER CHROMATOGRAPHY

Large-leaf gentian herb is a promising source of biologically active substances, which is actively used in the traditional medicine of many countries. It contains flavonoids, iridoids, secoiridoids, polysaccharides, xanthones with a wide spectrum of pharmacological activity. The aim of the research was to establish a procedure for identification of large-leaved gentian (Gentiana macrophylla Pall.)...

V. A. Tsukurova *, O. V. Evdokimova, N. P. Sadchikova and A. A. Matyushin

Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 8-2 Trubetskayast, Moscow, Russian Federation.

DOI: 10.13040/IJPSR.0975-8232.11(2).631-36

631-636

422

150

16.

ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF DOREMA AMMONIACUM GUM EXTRACTS AND MOLECULAR DOCKING STUDIES

Ammoniacum gum is traditionally used as an expectorant, stimulant, antispasmodic, catarrh, asthma, chronic bronchitis, and enlargement of liver and spleen in Medicine. The Soxhlet extraction of the oleo gum resin of D. ammoniacum was carried out with organic solvents including hexane, dichloromethane, chloroform, ethyl acetate, and methanol. The screening of the anti-alzheimer activity of the extr...

M. Mazaheritehrani *, R. Hosseinzadeh, M. Mohadjerani, M. Tajbakhsh and S. N. Ebrahimi

Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.

DOI: 10.13040/IJPSR.0975-8232.11(2).637-44

637-644

467

185

17.

ANTIOXIDANT AND BRINE SHRIMP LETHALITY BIOASSAY OF PECTIN FROM GRAPE FRUIT (CITRUS PARADISI) AND LEMON (CITRUS LIMON)

Pectin is a complex polysaccharide and has been used in food and pharmaceutical industries. The current study aimed to determine antioxidant and cytotoxic activities of pectin from peels of grape fruit (GP) and lemon (LP) by ferric reducing power (FRP) assay and brine shrimp lethality bioassay respectively. In addition, antioxidant and cytotoxic activities of GP and LP were compared with food-grad...

S. Qadir, N. H. Siddiqui, A. Ahmed, I. Azher and Z. A. Mahmood *

Department of Pharmacognosy and Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.11(2).645-51

645-651

160

58

18.

DEVELOPMENT CHARACTERIZATION OPTIMIZATION OF ETHOSOME CONTAINING DULOXETINE FOR TRANSDERMAL DELIVERY

The present investigation deals with the development of duloxetine ethosome then loading into the transdermal patch to impart lower drug side effect, enhanced bioavailability, avoiding first-pass metabolism. 32 factorial design was applied to optimize the formulation. Ethanol (X1) and Phospholipid (X2) were taken as independent variable, Responses are vesicle size (Y2), entrapment efficiency (Y1)....

E. Kumar * and C. N. Patra

Department of Pharmaceutics, University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).652-59

652-659

225

65

19.

ANTIDIABETIC EFFECT OF METHANOLIC EXTRACT OF WHOLE PLANT OF LINDERNIA CILIATA (COLSM.) PENNELL. ON STREPTOZOTOCIN INDUCED DIABETIC RATS

During the past few years many phytochemicals responsible for anti-diabetic effects have been isolated from the plants. Several phyto-constituents such as alkaloids, glycosides, flavonoids, saponins, dietary fibers, polysaccharides, glycolipids, peptidoglycans, amino acids and others obtained from various plant sources that have been reported as potent hypoglycemic agents. In the present study, th...

G. Reddy and V. S. Rani *

Department of Pharmacognosy and Phytochemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).660-68

660-668

238

75

20.

ANATOMICAL AND HISTOCHEMICAL CHARACTERISTICS OF MORINDA CITRIFOLIA L. (RUBIACEAE)

Morinda citrifolia (L.) is an important medicinal plant belonging to the family Rubiaceae and commonly known as “Noni” in Tamil was highly distributed in South India. The aim of this research is to understand the concept and techniques of anatomical and histochemical localization of secondary metabolites in Morinda citrifolia (L.) as well as take part in the standardization of herbal medicine....

S. Mownika, E. K. Ramya and S. Sharmila *

Department of Botany, Vellalar College for Women (Autonomous), Thindal, Erode, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).669-77

669-677

208

57

21.

PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF AEGLE MARMELOS FRUIT IN CYCLOPHOSPHAMIDE INDUCED TOXICITY IN RATS

Aegle marmelos commonly known as Bael has been widely used traditionally due to its various medicinal properties. Cyclophosphamide is an alkylating agent used in the treatment of various types of cancer by slowing or stopping the growth of cancer cells but also affecting the normal cells leading to immunosuppressant effect. The present study has been aimed to see the protective effect of hydroalco...

D. Patel * and D. Patel

Department of Pharmacology, Parul Institute of Pharmacy, Limda, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).678-86

678-686

176

61

22.

AN EVALUATION OF THE PROTECTIVE ROLE OF ESCITALOPRAM IN STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHY

Objective: The aim of the present study was the evaluation of the protective role of escitalopram in streptozotocin-induced diabetic neuropathy. Materials and Methods: Diabetes was induced in Wistar rats with streptozocin 70 mg/kg and animals were divided into four groups namely normal control, diabetic vehicle control, glibenclamide control and escitalopram group. After the 4th week of diabetes...

B. Nagaraju *, Y. Kranthi, C. Kommavari and K. Prasad

Department of Pharmacology, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).687-92

687-692

135

52

23.

SPHAEROCOCCUS CORONOPIFOLIUS ALLEVIATES OXIDATIVE BRAIN INJURY ASSOCIATED TO DEPRESSION-RELATED BEHAVIOR INFEMALE WISTAR RATS

Neuropathic pain is commonly comorbid with mood disorders, such as depression and anxiety. A state of depression may suggest biochemical imbalance that can increase the oxidative stress into the brain. The present study aimed to investigate the effect of aqueous extract of the red algae Sphaerococcus coronopifolius on depression-induced behavioral alterations and oxidative stress in female Wistar ...

F. Fellah *, R. Djenidi, Y. Bellik and A. Dehbi-Zebboudj

Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, Algeria.

DOI: 10.13040/IJPSR.0975-8232.11(2).693-99

693-699

157

54

24.

IN-VITRO AND IN-VIVO ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACT OF AERIAL PARTS OF ALANGIUM SALVIFOLIUM SUB-SPECIES HEXAPETALUM (WANGERIN)

Alangium salvifolium is a plant that is traditionally used to treat many diseases like laxative, antiepileptic, jaundice, antiulcer agent, agent to alleviate spasms, anthelmintic, emetic, antiprotozoal agent and hypoglycemic agent. Its subspecies Alangium salvifolium subsp. Hexapetalum (Wangerin) is also known for a variety of traditional use like hemorrhoids, rheumatism, and antidote for snake b...

H. Seena *, N. Kannappan and P. M. Kumar

Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).700-04

700-704

136

59

25.

IN-VITRO ANTIBACTERIAL EFFECT OF MUPIROCIN IN COMBINATION WITH THREE ESSENTIAL OILS AGAINST STAPHYLOCOCCUS AUREUS

Mupirocin is a topical antibiotic which is very effective against staphylococci, streptococci and Methicillin-Resistant Staphylococcus aureus (MRSA) infection. Because of its high effectiveness against MRSA infection, it is frequently used in clinical practice for decolonization of MRSA. Due to the increased use of mupirocin, increased resistance rates have been reported. Essential oil is a natura...

S. Mahalakshmi and V. Sankar *

Department of Pharmaceutics, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).705-09

705-709

182

64

26.

A STUDY OF ETHNOMEDICINAL PLANT DIVERSITY OF SACRED NATURAL SITES OF PANCHKOSHI PILGRIMAGE OF VARANASI, UTTAR PRADESH INDIA

Introduction: Medicinal plants have always played a major role in primary health care system since time immemorial. Sacred natural sites is the prime place to encompass large medicinal plant with wide range of natural resources. It potentially conserves plant biodiversity with inclusion of sacred places and sacred water bodies. Apart from social and religious importance it, regulate air and water ...

S. K. Patel, A. Sharma, A. K. Tiwari and G. S. Singh *

Institute of Environment & Sustainable Development, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).710-20

710-720

197

48

27.

DOCKING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE CONTAINING SCHIFF BASES FOR ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES

Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxaci...

D. Mopuri, S. V. Syed * and A. Madhulatha

Department of Pharmaceutical Analysis, Acharya Nagarjuna University College of Pharmaceutical Sciences Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).721-31

721-731

182

65

28.

ESTIMATION OF TOTAL FLAVONOIDAL CONTENT AND NOOTROPIC ACTIVITY OF LEPIDIUM SATIVUM

Objective: Lepidium sativum (Garden cress) is traditionally an important plant with a wide range of activities from the ages. Ample literature about its biological activities, motivate us to evaluate the total flavonoids content and to screen the nootropic activity in mice. Methods: Ethanolic extract was prepared from the seeds of Lepidium sativum using ethanol (70% v/v) and total flavonoids conte...

A. Jabeen *, S. Rani and M. Ibrahim

Department of Pharmacognosy, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).732-36

732-736

191

56

29.

BIOMOLECULAR CHANGES DUE TO STREPTOCOCCUS MUTANS INFECTION AND ANTIBIOTICS TREATMENT IN THE HUMAN DENTAL CARIES – SILKWORM (BOMBYX MORI) DISEASE MODEL

Changes in the hemolymph protein and trehalose contents of the silkworm, Bombyx mori L. due to Streptococcus mutans infection and antibiotics treatment was evaluated. Interestingly, S. mutans, which was successfully grown in the body of the larvae led to decline 69.60 and 50.21% of protein content in the hemolymph. Concomitantly, there was a drastic rise in the content of trehalose to 60.22 and 65...

M. L. Gowda and H. B. Manjunatha *

Department of Studies in Sericulture Science, University of Mysore, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).737-44

737-744

141

52

30.

SYNTHESIS, IDENTIFICATION OF IN-SILICO INTERACTIONS AND BIOLOGICAL STUDIES OF NOVEL SCHIFF BASE LIGAND AND ITS COPPER (II) COMPLEX

A novel copper (II) complex has been synthesized with Schiff base ligand obtained by the reaction of substituted carbohydrazone and thiosemicarbazide hydrochloride from the condensation reaction of ester and primary aromatic amine. The synthesized ligand and its copper (II) complex were characterized by various spectroscopic techniques like FT-IR, H1 NMR, UV-Visible, Fluorescence, powder XRD and T...

S. Rai, A. Agrawal and R. Kothari *

Department of Chemistry, School of Sciences, ITM University, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).745-54

745-754

158

61

31.

DESIGN AND DEVELOPMENT OF BENDAMUSTINE LOADED CHITOSAN NANOPARTICLE IN-VITRO CYTOTOXICITY

Nanoparticles represent one of the alternatives in the treatment of cancer chemotherapy. In the present study, the prime objective was to formulate anti-cancer drug, bendamustine into polymeric chitosan nanocarrier system for its sustained release and passive targeting mechanism. Based on particle size, zeta potential and polydispersity index, F3 was selected as the optimized formulation. The SEM ...

C. Sankar *, S. Muthukumar, G. Arulkumaran, S. Shalini, R. Sundaraganapathy and N. Vanitha

Department of Pharmaceutics, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).755-64

755-764

131

59

32.

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF COLEUS VETTIVEROIDES ROOTS ON EXPERIMENTALLY INDUCED HEPATO TOXIC MODELS

The present study was aimed to assess the hepatoprotective activity of ethanolic extract of Coleus vettiveroides on experimentally induced hepatotoxic models. Phytochemical screening of EECV was carried out and the results showed the presence of carbohydrates, alkaloids, tannin, flavonoids, phenolics, proteins and aminoacid, steroids and triterpenoids. HPTLC screening of EECV was carried out along...

A. Abarnadevika * and T. R. Nisha

KMCH College of Pharmacy, Affiliated by the Tamil Nadu Dr. MGR Medical University, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).765-73

765-773

131

58

33.

DEVELOPMENT AND CHARACTERIZATION OF POLYMERIC MICROPARTICLES CONTAINING MURRAYA KOENIGII LEAVES EXTRACT FOR MANAGEMENT OF DIABETES MELLITUS

Objective: Formulation and development of polymeric microparticles containing murrayanol for better treatment of diabetes mellitus. Methods: Successive solvent extraction of leaves of Murraya koenigii plant was done. The active constituent of leaves that is murrayanol was isolated and identified through HPLC and FTIR. Polymeric microparticles were selected as a carrier system and formulated by the...

N. Salvi * and G. P. Choudhary

Department of Pharmaceutics, Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).774-79

774-779

151

49

34.

THE EFFECT OF GOAT MILK CONSUMPTION ON BLOOD CALCIUM AND HEMOGLOBIN IN SOCCER PLAYERS

Calcium and iron are the main minerals needed to support performance and also to improve the physical components of soccer players. This study aims to analyze the effect of goat milk consumption on calcium and blood hemoglobin levels in junior soccer players. This study was an experimental study with a pretest-posttest design. Research subjects were 22 soccer players, male, aged 12-14 years. The t...

Y. Yusni * and A. Amiruddin

Department of Physiology, Faculty of Medicine, Universitas Syiah Kuala, Jalan Teuku Tanoh Abee, Kopelma Darussalam, Syiah Kuala, Banda Aceh, Aceh, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.11(2).780-83

780-783

153

64

35.

STABILITY INDICATING UHPLC METHOD FOR SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND LEDIPASVIR IN TABLET DOSAGE FORM

A stability-indicating UHPLC method was developed for the simultaneous estimation of Sofosbuvir (SOF) and Ledipasvir (LPS) in bulk and tablet dosage form. The study was performed using C18 BEH column (210 mm × 50 mm, 1.7 µm), with a mobile phase consisting of acetonitrile (55% v/v) and phosphate buffer of pH 3 (45% v/v) at a flow rate of 0.3 ml/min. The detection was carried at 247 nm using PDA ...

D. Narla * and N. Pappula

Department of Pharmaceutical Analysis, Aditya College of Pharmacy, Surampalem, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).784-90

784-790

195

59

36.

IN-VIVO ANTIHYPERLIPIDEMIC ACTIVITY AND PRELIMINARY PHYTOCHEMICAL SCREENING OF BAUHINIA ACUMINATA

The global burden of CVD is rising due to its increasing prevalence in lower- and middle-income countries where 80% of all global CVD-related deaths occur. Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. The present study was aimed to investigate the potential antihyperlipidemic activity of ethanolic leaf extract of Bauhinia acuminata in atherogenic di...

A. Govindula *, M. S. Reddy, M. Manjula, M. S. Reddy, Nusrath and P. Kalyani

Department of Pharmacology, Vaageswari College of Pharmacy, Beside LMD Police Station, Thimmapur, Karimnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).791-98

791-798

142

78

37.

ANTIBIOTIC SUSCEPTIBILITY PATTERN OF ESBL PRODUCING BACTERIA FROM URINARY TRACT INFECTION (UTI)

Antibiotics inhibit bacterial cell wall synthesis, protein synthesis or nucleic acid replication. The antibiotic must have access to and bind to its bacterial target site. Whether antibiotic resistance is intrinsic or acquired, the genetic determinants of resistance encode specific biochemical resistance mechanism that may include enzymatic inactivation of the drug, alteration to the structure of ...

J. Hattewar *, A. Koul and A. Mathur

NCS Green Earth Pvt. Ltd., M-7, MIDC Hingna Industrial Area, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).799-10

799-810

250

54

38.

STANDARDIZATION OF PARPATAKA (PERISTROPHE PANICULATA) – AN AYURVEDIC DRUG

The drug Parpataka is used particularly for the treatment of fevers, indigestion, biliousness, burning of the body, tired feeling, giddiness, urinary discharges, vomiting, thirst, enriches the blood and works good in leprosy. The present study is intended to authenticate and validate the species of Peristrophe paniculata (Forssk.) Brummitt, which is one of the sources of the Parpataka drug used...

B. Jyothi, G. P. Pratap *, M. K. Husain, M. Swamy, G. P. Prasad and G. Sudarsanam

Survey of Medicinal Plants Unit (SMPU), National Research Institute of Unani Medicine for Skin Disorders (NRIUMSD), Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).811-19

811-819

166

85

39.

FACTORS AFFECTING NON-RETENTION IN METHADONE MAINTENANCE TREATMENT: A RETROSPECTIVE STUDY IN CURE AND CARE CENTRE CHOW KIT, MALAYSIA

Methadone Maintenance Treatment (MMT) is a national harm reduction program in Malaysia that prevents opioids withdrawal, reduces cravings, and aids in the drug abuser’s recovery. Treatment retention is used as a measure of MMT effectiveness. However, it is often associated with many factors that cause premature termination. Our study aimed to analyze the percentage of loss to follow-up patients ...

A. M. Suhaimi *, S. F. K. Azam, N. H. A. Samah, S. A. Ariffin and I. A. Wahab

Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam Campus, Bandar Puncak Alam, Selangor, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.11(2).820-25

820-825

163

43

40.

SYNTHESIS, CHARACTERIZATION AND ANTITUBERCULAR ACTIVITY OF 6-(ARYL)-2-(SUBSTITUTED METHYL)-4,5-DIHYDRO(2H)PYRIDAZIN-3-ONE DERIVATIVES AGAINST MYCOBACTERIUM TUBERCULOSIS H37RV

Two series of pyridazinone derivatives, 6-(aryl)-2-(substituted methyl)-4,5-dihydro (2H) pyridazin-3-one derivatives (3a-8a and 3b-8b) were synthesized by reacting 6-phenyl substituted 2,3,4,5-Tetrahydro pyridazin-3-one (2a and 2b) with cyclic secondary amine under Mannich reaction conditions. These final compounds (3a-8a and 3b-8b) were characterized by spectral analysis (IR, 1HNMR and mass spect...

M. Asif *, Abida and M. Imran

Department of Pharmaceutical Chemistry, Himalayan Institute of Pharmacy and Research, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).826-31

826-831

134

58

41.

PHARMACOLOGICAL EVALUATION OF ANTI-DIABETIC EFFECTS OF COMBINED DOSES OF MOMORDICA CHARANTIA AND STEVIA REBAUDIANA AGAINST STZ INDUCED DIABETES MODEL

Diabetes mellitus is one of the most prevalent pathogenic conditions which affect around 6% of the world population. Diabetes mellitus is a systemic metabolic disorder, which is characterized by hyperglycemia, hyperlipidemia, hyperaminoacidemia, and hypoinsulinemia. Although, there are different approaches to minimize the ill effects of diabetes and its complications, herbal formulations are favor...

R. Singh *, R. K. Srivastava and A. Srivastava

Hygia Institute of Pharmaceutical Education and Research, Faizullaganj, Prabandh Nagar, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).832-38

832-838

160

54

42.

VARIOUS MEDICINAL PLANTS: A PROMISING TREATMENT FOR MULTIDRUG-RESISTANT BACTERIA ISOLATED FROM WOUND INFECTION

Bacteria have proved remarkably developing resistant to a known antibiotic; however, Medicinal plants have manifested notably useful for the control of bacterial infections. This study aimed to isolate and identify the multidrug-resistant bacteria from wound infection, then examine the antibacterial activity of different concentration of the ethanolic extracts of Cymbopogon proximus, Azadirachta i...

E. H. O. Moglad *, S. K. A. Boon and H. T. O. Ali

Department of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(2).839-43

839-843

165

51

43.

THE POSSIBLE PROTECTIVE EFFECT OF FRESH BEETROOT JUICE AGAINST PARACETAMOL INDUCED HEPATOXICITY IN ADULT ALBINO RATS

Hepatotoxicity in the form of acute liver failure is a serious side effect of several drugs most importantly paracetamol. Beetroot main ingredients are nitrate, betalains, phenolics and ascorbic acid, which are responsible for its protective against oxidative stress and inflammation. Aim: This study assessed the possible protective effect of beetroot against liver toxicity induced by paracetamol. ...

A. Al-Qtaitat *, A. Al-Maathidy, S. S. Farhan, G. Almuhaisen and J. A. M. Alzyoud

Department of Anatomy and Histology, Faculty of Medicine, Mutah University, Karak, Jordan.

DOI: 10.13040/IJPSR.0975-8232.11(2).844-52

844-852

150

56

44.

AMELIORATION OF DEXTRAN SULPHATE SODIUM INDUCED ULCERATIVE COLITIS IN MICE BY STEM BARK EXTRACT OF TERMINALIA TOMENTOSA

A plethora of herbs have been tested for their activity against ulcerative colitis, a debilitating disease in the group of IBDs. However, a promising adjuvant to conventional therapy remains still at large. Ellagic acid, a polyphenol widely available in berries have shown efficacy against ulcerative colitis in preclinical models. Owing to its high content of ellagic acid and its analogs, the stem ...

A. Das *, S. Patil, S. K. Mukhopadhyay and A. G. Patil

Department of Pharmacology, Gupta College of Technological Sciences, Asansol, Burdwan (W), West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).853-61

853-861

161

47

45.

DEVELOPMENT AND VALIDATION OF FTIR SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN PURE AND PHARMACEUTICAL DOSAGE FORMS

A new analytical method has been developed for the simultaneous estimation of Telmisartan and Hydrochlorothiazide in their pure and pharmaceutical dosage forms by using Fourier Transform Infrared (FTIR) Spectroscopy. This method involves the extraction of Telmisartan and Hydrochlorothiazide from tablets using chloroform and direct measurement in liquid phase mode using reduced path length cell. Th...

Y. Padmavathi *, R. Chilka and R. Tummala

G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).862-72

862-872

150

53

46.

FORMULATION, CHARACTERIZATION AND EVALUATION OF ISOTRETINOIN GEL FOR TREATMENT OF ACNE VULGARIS

Acne vulgaris is a commonly diagnosed inflammatory skin condition that affects pediatric, young and adult patients. The object of the paper is formulation development and evaluation of isotretinoin gel for the treatment of Acne vulgaris. The isotretinoin based anti-acne gel was formulated using different polymers includes carbopol 940, carbopol 934 and carbopol 980. Disodium edetate is used as ch...

S. Gupta and A. Bharadwaj *

RKDF College of Pharmacy, SRK University, Misrod, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).873-83

873-883

149

61

47.

FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF OFLOXACIN BY USING DIFFERENT NATURAL SUPER DISINTEGRATING AGENTS

Fast disintegrating tablets have received ever-increasing demand during the last decade, particularly the fast disintegrating tablet drug delivery systems formulated with natural polymers have more demand because natural materials are easily available, easy to administer, non-toxic and non-irritant nature etc. The main aim of the present study was to formulate the fast dissolving tablet of Ofloxac...

S. Singh *, S. Mandal and N. Verma

Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).884-95

884-895

155

66

48.

ISOLATION AND SCREENING OF CYANOBACTERIAL CULTURES FROM BILASPUR DISTRICT OF CHHATTISGARH: EXTRACTION AND PURIFICATION OF BIO-ACTIVE METABOLITES

Metabolites from natural sources (microbes, plants, animals) have helped to double the human life span during the 20th century, combated pain and suffering, and revolutionized the practice of medicine. Microbes have provided compounds that have cured or reduced the effect of human diseases for 70 years. Microbial products include antibiotics against bacteria and fungi, antitumor drugs, immunosuppr...

K. Sharma *, S. Parkhey and F. Dabahadker

Government A & C Girls College, Raipur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).896-00

896-900

153

48

49.

MONITORING AND ANALYSIS OF ADR IN PATIENTS COMING TO PSYCHIATRY OPD WITH DEPRESSION AT A TERTIARY CARE HOSPITAL IN NORTHERN INDIA

AIM: To monitor the adverse drug reactions due to various antidepressants prescribed in patients coming to psychiatry OPD with depression at a tertiary care hospital in northern India. Methods: This was a prospective observational longitudinal study conducted for a period of 12 months in a tertiary care outpatient facility. Patients who fulfilled the inclusion and exclusion criteria and those who ...

S. Barua, P. Katiyar *, N. Kumar, V. Agarwal, R. Kumar, R. Nath, G. Adhaulia and R. K. Dixit

University Institute of Health Sciences CSJM University, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(02).901-06

901-906

165

49

50.

EFFECT OF QUERCETIN ON THE PHARMACOKINETIC PROFILE OF ELETRIPTAN, A CYP3A SUBSTRATE, IN RAT MODEL

Quercetin is a plant flavonol that is available from both daily diet and nutraceuticals. Various studies report that Quercetin alters the pharmacokinetics of various drugs by mechanisms like p-glycoprotein (p-gp) inhibition or other unknown mechanisms. The study was undertaken to evaluate the effect of Quercetin on the pharmacokinetics of Eletriptan. A single dose in-vivo pharmacokinetic study was...

N. Hematheerthani *, C. S. Reddy, A. P. Rani and P. S. Kumar

Nova College of Pharmacy, Vegavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).907-15

907-915

156

45

51.

PHARMACOLOGICAL EVALUATION OF ALCOHOLIC EXTRACT OF EUPHORBIA ANTIQUORUM WITH SPECIAL EMPHASIS ON DIABETIC COMPLICATION

Diabetes is a metabolic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. Diabetes is the most common cause of progressive kidney failure leading to dialysis or transplantation. Nephropathy is reported to develop in 30-40% of patients with diabetes and has become a leading cause of end-stage renal failure worldwide. The va...

P. K. Yadav * and S. S. Sisodia

Bhupal Nobles' College of Pharmacy, Faculty of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).916-21

916-921

160

64

52.

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR ESTIMATION OF VORAPAXAR BY UPLC-MS/MS: APPLICATION TO A PHARMACOKINETIC STUDY

The validated analytical method was applied for estimation of vorapaxar in aqueous and human plasma with vorapaxar-D5 as an internal standard by using UPLC-ESI-MS/MS. The chromatographic separation was achieved with 5mM Ammonium Formate Buffer (pH: 4.0): Methanol: Acetontrile, (40:30:30, % v/v) using the Pursuit XRs-100Å, C18, 4.6 × 50 mm, 10 µm. The total analysis time was 3.5 min and flow rat...

T. M. Rao, C. B. Reddy and P. S. Babu

Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).922-29

922-929

139

59

53.

A MULTIDISCIPLINE MANAGEMENT OF A CHILD WITH CHRONIC PYELONEPHRITIS CAUSED BY MULTIDRUG-RESISTANT E. COLI: A CASE STUDY

Escherichia coli is the predominant isolated type of bacteria in urinary tract infections in children. Multidrug resistance of this kind of infection is associated with an increased risk of kidney injury and, therefore, an increase in morbidity and mortality. This report presents a case of a 6-year-old child with recurrent pyelonephritis with multidrug-resistant E. coli. She was followed, in a tea...

A. Almohammadi

Faculty of Pharmacy King Abdul-aziz University, Jeddah Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(2).930-33

930-933

145

47

54.

FORMULATION AND EVALUATION OF SOLID SELF EMULSIFYING DRUG DELIVERY SYSTEM FOR DRUG MIRTAZAPINE

Objective: In the present dissertation work, the aim was to prepare self-emulsifying drug delivery systems (SEDDS) of mirtazapine to improve its solubility with a view to enhance its oral bioavailability. Methods: The prepared SEDDS was the concentrate of the drug, oil-Capmule MCM EP, surfactant tween 80 and PEG 400 as a co-surfactant. The optimized microemulsion was converted into solid form by a...

P. R. Shelake *, R. R. Shah, V. V. Nalawade and P. P. Majalekar

Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).934-46

934-946

155

68

55.

SYNTHESIS, CHARACTERIZATION, BIOLOGICAL AND FLUORESCENT BEHAVIOUR OF METAL (II) COMPLEXES WITH PYRAZOLINE DERIVATIVES

Novel metal complexes of ligands of pyrazoline derivatives were synthesized by the condensation of 1-acetyl-2-hydroxynapthalene and indole-3-carboxaldehyde followed by the condensation of substituted phenylhydrazine. They were characterized by elemental analysis, IR, 1H-NMR, UV-Vis., molar conductance, magnetic susceptibility measurements and electrochemical studies. Based on the magnetic moment a...

T. M. Sharmila

Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).947-54

947-954

162

58

56.

BIOFILM AND METTALO BETA-LACTAMASE PRODUCTION IN ASSOCIATION WITH SERUM RESISTANT ACTIVITY AMONG CLINICAL STRAINS OF PSEUDOMONAS AERUGINOSA

Biofilms are communities of bacteria that are append to a surface and play significant role in the persistence diligence of bacterial infections. Bacteria with a biofilm are more defiant to antibiotics compared with planktonic bacteria. Biofilm producing bacteria are able to take possession on medical devices such as catheters and implants. The incidence of Biofilm producing microorganism runs aro...

R. Pradeepraj, D. Jayarajan and M. C. Harish *

Department of Biotechnology, Thiruvalluvar University, Vellore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).955-64

955-964

193

69

57.

NEUROPROTECTIVE EFFECT OF MORUS NIGRA L. (MULBERRY) FRUIT EXTRACT ON ACRYLAMIDE – INDUCED DANIO RERIO (ZEBRAFISH)

In the current scenario, high concentrations of acrylamide (ACR), a water-soluble vinyl monomer, which is used industrially and also found in thermally processed carbohydrate-rich foods, poses serious health risks to humans. Oxidative stress is an important mediator of central and peripheral neurotoxicity, which is one of the most recognized toxicological effects of high concentration acrylamide e...

K. G. Singh *, S. Johnson, P. Keerthana and P. Vyshali

Department of Biochemistry, Mount Carmel College, Autonomous, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).965-70

965-970

140

56

58.

PHARMACOGNOSTIC STUDIES AND MONOGRAPHIC DEVELOPMENT OF FICUS GLOMERATA ROXB. FROM THE GREAT GANGETIC PLAIN

In this study attempt has been made to develop the monographic parameters for Ficus glomerata Rox. leaves were collected from Gangetic plains (Lucknow). Under the study, pharmacognostic parameters were performed including macroscopic characters, microscopic characters, physicochemical parameters (extractive values, ash values, pH analysis, LOD), and preliminary phytochemical screening. Apart from ...

P. Deep *, A. Mishra and N. Verma

Amity Institute of Pharmacy, Amity University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).971-77

971-977

124

36

59.

PRODUCTION OF BIODIESEL FROM AGRO-INDUSTRIAL WASTE

Fossil fuels are significantly depleted nowadays due to excess utilization. Therefore, it is always better to find alternatives to produce eco-friendly fuels. This paper deals with the production of biodiesel from agro-industrial waste such as young coconut husk, custard apple seeds and broiler chicken skin. Lipids were isolated from the substrates using the modified Bligh and Dyer method and tran...

A. B. George, M. Joy, F. J. Xavier and E. Venkatanagaraju *

Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(2).978-86

978-986

156

51

60.

ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) IN HAIL REGION, SAUDI ARABIA

Background: Acute respiratory distress syndrome (ARDS) is a medical condition occurring in critically ill patients characterized by extensive inflammation in the lungs and associated with several complications. Therefore, the present study aimed to identify the common risk factors associated with ARDS in Hail Region, Northern Saudi Arabia. Methodology: This study investigated retrospectively 68 pa...

H. G. Ahmed *, F. K. Alquwaiay, H. F. Al-Dhamadi, A. F. Alzamil, I. H. E. Alshammari and K. M. Altayep

College of Medicine, University of Hail, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(2).987-92

987-992

175

278