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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 4 (2013) - Issue 6, June

Review Articles

 
Title
Views
PDF
Cited
1.

ANGIOGENESIS AND CANCER THERAPY

Cancer spreads by metastasis which is the ability of cancer cells to penetrate into lymphatic and blood vessels, circulate through the bloodstream, and then invade and grow in normal tissues elsewhere. It is this ability to spread to other tissues and organs that makes cancer a potentially life-threatening disease. Cancer researchers involve in the study of the conditions necessary for cancer meta...

D.O. Acheampong*, J. Zhang and M. Wang

Department of Molecular Biology, State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2021-27

2021-2027

1363

580

2.

NANO – STRUCTURED HERBAL ANTIMICROBIALS

The use of traditional medicines of natural origin is being encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may cause unpredictable adverse effects. The various strategies which have been identified to defeat drug resistance, the investigation of new and effective natural products exhibiting antimicrobial activity against pathogenic microorganisms is likely to p...

Rachna Gupta*, Pramod W. Ramteke , Himanshu Pandey and Avinash C. Pandey

Department of Biological Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad- 211007, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2028-34

2028-2034

1924

560

3.

TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL: AN EMERGING TARGET FOR PAIN

Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action potentials in somatosensory nociceptors. Here we highlight the role...

S. S. Khot*, H.Y. Shaikh and R.S. Patil

Core Vaccine Research Unit (CVRU), Vadu Rural Health Program, KEM Hospital Research Centre, Sardar Moodliar Road, Rasta peth, Pune- 411011, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2035-44

2035-2044

1556

460

4.

GREEN SYNTHESIS OF THIAZINE AND OXAZINE DERIVATIVES – A SHORT REVIEW

A survey of green synthesis of thiazines and oxazines revealed the moiety have attracted a great deal of interest of medicinal chemist, biochemist, pharmacologist and rendered as a lead molecule for designing potential bioactive agents. This review accompanying supplementary green synthetic information & its references would extend great deal of help to researchers in determining the best and ...

Sayaji S. Didwagh and Pravina B. Piste*

P.G. Department of Chemistry, Yashavantrao Chavan Institute of Science, Satara-415 001, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2045-61

2045-2061

3306

1506

5.

EXCITOTOXICITY AND CELL DAMAGE – A REVIEW

Excitotoxicity refers to the pathological process by which nerve cells are damaged & killed by glutamate or related excitatory amino acid under conditions such as after intense exposure. This occurs when receptor for the excitatory neurotransmitter such as N-methyl-D-aspartate (NMDA) or AMPA are over activated. Such excitotoxic neuronal death may take part in the pathogenesis of brain or spina...

Saba Shaikh*, Ravi Dubey, Y.M. Joshi and Vilasrao J. Kadam

Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, Sector-8, C.B.D. Belapur, Navi Mumbai-400614, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2062-66

2062-2066

1945

649

6.

AN UPDATE ON DISEASE PROFILE OF CANCER WITH HERBAL TREATMENT

There has been a vast growth in the field of herbal medicine and these drugs popularly are increasing both in developing and developed countries because of their natural origin, more therapeutic effect and less side effects. Since ancient cultures, tribal people methodically collected information on herbs and developed well-defined herbal drugs for the treatment of many diseases. In cancer, cells ...

Parul Agarwal*, Amreen Fatima , Shashi Alok , P.P. Singh and Amita Verma

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2067-79

2067-2079

2464

615

7.

MEDICINAL CHEMISTRY AND DEVELOPMENT OF ANTITUBERCULAR DRUGS

Tuberculosis (TB) is an ancient disease that has caused inestimable suffering and claimed millions of lives over the centuries. Resistant strains of Mycobacterium tuberculosis have slowly emerged especially in developing countries due to the lack of health care organisation in order to provide the long and costly treatment adapted to patients. In fact, 90% of all TB cases occur in the developing w...

Piyush Kumar*, Pinki Rawat and Pooja Singh

M.S. (Pharm.) Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2080-93

2080-2093

2747

606

8.

SOLID DISPERSIONS: A REVIEW ON DRUG DELIVERY SYSTEM AND SOLUBILITY ENHANCEMENT

Solid dispersions, defined as the dispersion of one or more active pharmaceutical ingredient in a carrier at solid state and an efficient technique to improve dissolution of poorly water-soluble drugs to enhance their bioavailability. Poor water solubility is one of the major problems for the various types of drugs and various approaches have been introduced for the enhancement of solubility of su...

Dharna Allawadi*, Neelam Singh, Sukhbir Singh and Sandeep Arora

Chitkara College of Pharmacy, Chitkara University, Chandigarh Patiala National Highway (NH-64), Tehsil-Rajpura, Distt-Patiala-140401, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2094-05

2094-2105

6005

1031

9.

BOSWELLIA SERRATA ROXB. A TRADITIONAL HERB WITH VERSATILE PHARMACOLOGICAL ACTIVITY: A REVIEW

Boswellia serrata Roxb. is known as kundur in Unani medicine, belongs to the family Burseraceae. The plant is widely distributed in India, it occurs in dry hilly forests of Rajasthan, Madhya Pradesh, Gujarat, Bihar, Assam, Orrisa, central peninsular regions of Andhra Pradesh etc. In ancient times Hindus, Babylonians, Persians, Romans, Chinese, Greeks and the people of old American civilization use...

Arshiya Sultana*, Khaleeq Ur Rahman , A.R. Padmaja and Shafeeq Ur Rahman

Lecturer, Department of Amraze Niswan wa Qabalat (Obstetrics and Gynecology), National Institute of Unani Medicine, PG Institute of Research, Bangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2106-17

2106-2117

4779

1936

10.

GLIAL CELLS RESPONSES: IN OPIOID WITHDRAWAL SYNDROME

Drug addiction represents one of the major medical, social, and economic burdens of human behavior. Opioids are powerful relievers; use of opioids for the treatment of pain has been associated with the potential disadvantages including development of tolerance, dependence. There are seven stages involved in opioid addiction. Identification of glial-mediated mechanism inducing opioid side effects i...

Gurpreet Bawa

Department of Pharmacology, Rayat and Bahra Institute of Phamacy, Sahauran, Kharar, District Mohali-140 104, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2118-31

2118-2131

1587

460

11.

BIOSIMILAR: AN OVERVIEW

Biosimilars are defined as officially approved new version of innovator bio-therapeutic products for which the patent has expired. Biosimilars the ‘generic’ versions of biopharmaceuticals, continue to enter Indian pharmaceutical market, to treat a variety of diseases. Biosimilars available in India include monoclonal antibodies for treating various malignant and immunological disorders, growth...

Sagar J. Kanase*, Yogesh N. Gavhane, Ashok Khandekar, Atul S. Gurav and A.V. Yadav

Department of Biopharmaceutics, Government College of Pharmacy, Karad- 415 124, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2132-44

2132-2144

4356

1389

12.

A REVIEW OF PELLETS AND PELLETIZATION PROCESS – A MULTIPARTICULATE DRUG DELIVERY SYSTEM

Multiparticulate drug delivery systems like pellets, granules, micro particles, minitablets etc., prove to be promising and highly flexible systems with ease of formulating with different drug release kinetics. These multiparticulate dosage forms are essential where drug-excipients or drug-drug physicochemical interactions are possible in a single-unit formulation. In present times, pelletization ...

V. R. Sirisha K.*, K. Vijaya Sri , K. Suresh , G. Kamalakar Reddy , N. Devanna

Department of Pharmacy, JNTUA, Anantapur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2145-58

2145-2158

15682

2439

13.

THREE GENERATIONS: PIMARY, SECONDARY AND TERTIARY GENERATIONS OF TRANSDERMAL DRUG DELIVERY SYSTEMS: A REVIEW

From this article, we get the knowledge about the transdermal patch, transdermal drug delivery system and anatomy of the skin. Now-a-days transdermal drug delivery, system is widely used in much disease. So, this article gives the knowledge about pre transdermal system, post transdermal drug delivery system and future of transdermal drug delivery systems and examines the benefits and limitations o...

Arjun Dedakia*, Chetan Matholiya , Vaishali Koyani and Dipen Bhimani

Department of Pharmaceutics, Saurashtra University, Rajkot-360 005, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2159-73

2159-2173

6625

1177

14.

DENDRIMERS – A NEW CLASS OF POLYMERS

Dendrimers are highly branched and reactive three-dimensional macromolecules, with all bonds emanating from a central core. Compared with traditional linear polymers, Dendrimers have much more accurately controlled structures, with a globular shape, a single molecular weight rather than a distribution of molecular weights, and a large number of controllable ‘peripheral’ functionalities. All th...

Saritha Thatikonda*, Shiva Kumar Yellanki , Swamy Charan D. , Arjun D. and Anna Balaji

Department of Pharmaceutics, Lalitha college of Pharmacy, Venkatapur (V), Ghatkesar(M), Ranga Reddy (Dt.) Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2174-83

2174-2183

2075

575

15.

PEGINESATIDE- A NOVEL ERYTHROPOIETIN MIMETIC AGENT FOR THE TREATMENT OF ANAEMIA IN CHRONIC RENAL FAILURE PATIENTS

Anaemia associated with chronic kidney disease (CKD) affects the overall health of the patients leading to increased morbidity and mortality. Erythropoietin stimulating agents (ESAs) have been the standard of care for the treatment of such patients since last 20 years. These agents have the potential to increase mean haemoglobin levels in both pre dialysis and dialysis maintenance phases hence low...

R. Nandha*, A. Maheshwari , K. Sekhri and S. Aditya

Assistant Professor, Department of Pharmacology, Dr. Harvansh Singh Judge Institute of Dental Sciences , Sector 25, Panjab University, Chandigarh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2184-89

2184-2189

1379

387

Research Articles

 
Title
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16.

SOLUTION PROPERTIES AND THE MASKING OF UNPLEASANT TASTES OF NICOTINE – SWEETENER – WATER MIXTURES

Solutions properties of sapide molecules provide fundamental information on type (hydrophobic or hydrophilic) and degree of hydration. Physico-Chemical properties like intrinsic viscosity, Apparent Specific Volume (ASV) and related parameters for bitter molecule (nicotine) and bitterness inhibitors (carbohydrate sweeteners, artificial sweeteners) and their mixtures were determined to study the rol...

Vincent Aroulmoji, Mohamed Mathlouthi and M.O. Portmann-Richardson

Director R & D, Mahendra Educational Institutions, Mallasamudram - 637 503, Namakkal District, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2190-98

2190-2198

1647

453

17.

HETEROGENEITY OF IRON STATUS AND ANTIRETROVIRAL THERAPY DURING PREGNANCY IN CÔTE D’IVOIRE

Antiretroviral therapy for decades is the appropriate treatment for infected populations with human immunodeficiency virus (HIV). However, it is associated with complications that affect the organism infected. The combination of antiretroviral therapy and pregnancy degrades iron metabolism. This work aims to evaluate and characterize the impact of the interaction between antiretroviral therapy and...

Bleyere Mathieu Nahounou*, Kouakou Léandre Kouakou, Amonkan Augustin Kouaho , Doumatey Sylvie , Sawadogo Duni and Yapo Paul Angoué

Senior Lecturer, Physiology and Pathophysiology, Training and Research Unit of Natural Sciences, Nangui Abrogoua University, 02 BP 801 Abidjan 02, Ivory Coast

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2199-13

2199-2213

1491

405

18.

THE ANTIMICROBIAL ACTIVITY OF n-C6H14 AND CH3CH2OH EXTRACT OF SOLANUM MELONGENA FRUIT AND LEAVES OF MORINGA OLEIFERA

As part of a research initiative to evaluate plants used for their nutritional and herbal values, the antimicrobial activity of Solanum Melongena’s fruit and Moringa oleifera’s leaveswere investigated. Each plant part was subjected to selective extraction using solvents of varying polarity: n-C6H14, CH2Cl2, EtOAc and CH3CH2OH. The n-C6H14 and CH3CH2OH extract of these two plants were tested fo...

R.C. Jagessar* and N. Ramchartar

Department of Chemistry, University of Guyana, Georgetown, Guyana

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2114-20

2214-2220

1487

559

19.

TARGETED DELIVERY OF CATALASE TO MACROPHAGES BY USING SURFACE MODIFICATION OF BIODEGRADABLE NANOPARTICLE

Reactive oxygen species (ROS) produced by activated macrophages play a major role in causing liver disorders. Small antioxidants and scavengers are protective only at very high concentrations and they poorly detoxify toxic ROS. Catalase (CAT) is an antioxidant enzyme that scavenges ROS and has great potential for treating liver disorders. In the present research work, gelatin nanoparticles bearing...

Ajay Saraf *, Amit Dasani and Ashok Soni

Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2221-29

2221-2229

1331

452

20.

NOVEL GENTAMICIN LOADED ELECTROSPUN NANOFIBROUS SCAFFOLDS FOR WOUND HEALING: AN IN- VITRO STUDY

The extracellular matrix (ECM) is the backbone in controlling cell behavior in the living organisms during the process of wound healing. The design of a suitable biomimetic nanofibrous scaffold which mimics the properties of natural ECM is a need of present time. In order to create a novel and unique wound dressing material, composite nanoscaled eudragit scaffolds loaded with gentamicin were prepa...

Charu Dwivedi*, Himanshu Pandey , Avinash C. Pandey and Pramod W. Ramteke

Jacob School of Biotechnology and Bioengineering, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad, 211007, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2230-33

2230-2233

1837

844

21.

SENSITIVE AND SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF SPIRAMYCIN IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS

Three simple and sensitive and reproducible spectrophotometric methods were developed for the determination of spiramycin (SPM) in pure form and in pharmaceutical formulations (tablets). The first and second methods, A and B, are based on the formation of charge transfer complex between drug and the chromogenic reagents quinalizarin (method A) and alizarin red S (method B) producing charge transfe...

Ragaa El Sheikh, Ayman A. Gouda* and Khalil M. Khalil

Chemistry Department, Faculty of Sciences, Zagazig University, Zagazig, 44519, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2234-43

2234-2243

1624

515

22.

AN IN VITRO INVESTIGATION OF SUITABILITY OF PRESS-COATED TABLETS WITH HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE (HPMCAS) AND SODIUM ALGINATE IN OUTER SHELL FOR COLON TARGETING

The aim of present study was to develop a new colon targeting formulation, which can minimize the escape of Mesalazine completely in upper gastro-intestinal tract and ensure availability of maximum amount of drug to achieve the desired site i.e. distal colon. The use of press coated tablets with Hydroxypropylmethylcellulose acetate succinate (HPMCAS) and sodium alginate in outer shell was investig...

Krishnakumar Devrao Lone* and Jyoti Arjunrao Dhole

Lecturer in Pharmaceutics , JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2244-51

2244-2251

1429

376

23.

RP-HPLC ANALYSIS OF METFORMIN HYDROCHLORIDE AND VOGLIBOSE AND STUDY OF ITS DIFFERENT ANALYTICAL PARAMETER

A simple, specific, precise, and efficient method for the Simultaneous estimation of Metformin HCl and Voglibose tablet by a Reverse Phase-High Performance Liquid Chromatography method is developed and validated. Selected mobile phase were in a combination of acetonitrile: buffer pH- 6.5 in the ratio of 62:38. Optimized column is a stainless steel column packed with base octa decylsilyl silica gel...

K. Sonia* and K. Prasad Babu

Department of Pharmaceutical Analysis, K.K College of Pharmacy, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2252-57

2252-2257

2041

413

24.

STUDIES ON PENETRATION ENHANCERS IN CORPORATED CREAM OF CLOBETASOL-17-PROPIONATE: DEVELOPMENT AND IN VITRO EVALUATION

Topical corticosteroids have long been the chronic stage in the treatment of steroid responsive dermatitis. Creams containing 0.05% w/w Clobetasol-17-propionate (CP) as active ingredient are categorized as super potent class I topical dermatological corticosteroids. For the drug molecule to reach the cutaneous microcirculation, enhance, the systemic circulation, have to transverse both the lipophi...

Parveen Kumar* and Rubina Bhutani

Pharmacy Department, Shri Ram College of Pharmacy, Ramba, Karnal, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2258-64

2258-2264

1705

725

25.

SYNTHESIS, CHARACTERIZATION, DNA-BINDING, PHOTOCLEAVAGE AND ANTI-MICROBIAL STUDIES OF COMPLEX [Ru(4-ETHYL- PYRIDINE)4(DPPZ)]2+

The new Ru (II) complex [Ru(4-Et-py)4(dppz)]2+  (dppz = dipyrido phenazine) have been synthesized and characterized by different analytical techniques like elemental analysis, LC-MS,  1H NMR , 13C NMR. The interaction of this complex with calf thymus DNA has been explored by U.V. absorption spectroscopy, Fluorescence measurements, and viscosity measurements. Their photocleavage behavior towards ...

Padmaja Naishadham and S. Satyanarayana*

Department of Chemistry, Osmania University, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2265-73

2265-2273

1313

610

26.

FORMULATION AND EVALUATION OF PREDNISOLONE TABLETS USING BIO-DEGRADABLE NATURAL POLYSACCHARIDES AS A CARRIER IN COLON TARGETED DRUG DELIVERY

The purpose of this research was to develop and evaluate naturally obtained polysaccharides (Tamarind seed polysaccharide and Pectin) as a carrier in colon targeted drug delivery systems a colon targeted drug delivery. The newer developments in this context aim for an increased selectivity of drug delivery by targeting mechanisms which have a closer relation to pathophysiological particularities o...

Arun R. Raj

University College of Pharmacy, Mahatma Gandhi University RIMSR, Kottayam, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2274-79

2274-2279

2408

657

27.

GREEN SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF SILVER NANOPARTICLES PRODUCED USING IPOMOEA AQUATICA FORSK LEAF EXTRACT

Objective: The aim of the present study is to investigate the synthesis and characterization of Silver nanoparticles (AgNPs), and their antimicrobial effect on gram positive and gram negative bacteria by using hydro alcoholic leaf extract of Ipomoea Aquatica Forsk (HAEIA). Material and Methods: AgNPs were prepared by green synthesis process from 1mM AgNO3 solution the aqueous silver ions when e...

D. Sivaraman*, P. Panneerselvam , P. Muralidharan , T. Purushoth Prabhu and R. Vijaya Kumar

Assistant Professor, Department of Pharmacology and Toxicology, C.L. Baid Metha College of Pharmacy, Jyothi Nagar, Rajiv Gandhi Salai, Thoraipakkam, Chennai - 600097, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2280-85

2280-2285

1861

670

28.

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF SYNTHESIZED AGENTS USING UGI MULTICOMPONENT REACTION

In the present study, analgesic and anti-inflammatory activities of the synthesized agents derived from Ugi four component reactions (Ugi-4CR) has been described. The synthesized novel Ugi derivatives 7 (a-h) were characterized on the basis of I.R, 1H NMR and mass spectral analysis. Healthy Wistar Albino rats were used to carry out these activities. Analgesic activity was evaluated by Eddy hot pla...

Ipsita Mohanram* and Jyotsna Meshram

Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2286-91

2286-2291

1381

524

29.

PREPARATION AND CHARACTERIZATION OF NYSTATIN-LOADED SOLID LIPID NANOPARTICLES FOR TOPICAL DELIVERY

Solid lipid nanoparticle proved appropriate as prolonged release formulation for lipophilic drugs. The present work dealt with the preparation of the antifungal lipophilic drug nystatin into solid lipid nanoparticles ((Nyst-SLNs).) formulation for topical delivery with the aim to prolong its release and effectiveness. Hot homogenization and ultrasonication were applied in the production of (Nyst-S...

Rawia Khalil*, Mahfouz Kassem , Ahmed A. Elbary , Mohamed El Ridi and Mona AbouSamra

Department of Pharmaceutical Technology, National Research Centre, Dokki, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2292-00

2292-2300

3265

897

30.

REVERSAL OF ROSIGLITAZONE HEPATOTOXICITY BY SILYMARIN ON RATS

The present study was undertaken to investigate the hepatotoxic potential of rosiglitazone- an oral hypoglycemic thiazolidenedione class of drug. The hepatotoxic potential of rosiglitazone was assessed in-vitro on isolated rat hepatocytes before subjecting to in-vivo studies. The in-vitro activity was measured by trypan blue exclusion assay and determination of liver marker enzymes. The hepatotoxi...

Shivakumar Swamy, K.L. Krishna* and Ramesh B. Nidavani

Department of Pharmacology, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570 015, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2301-07

2301-2307

1511

452

31.

ATLAS OF MACRO-MICROSCOPY OF RAW DRUG SOLD AS MUSTA – CYPERUS ROTUNDUS (L.)

The quest for eternal health has made mankind to intensively research the nature itself. Nature has a rich source of medicinal plants, the proper use of which is necessary to maintain health. According to WHO, almost 80% of the population of developing countries has utmost faith in traditional medicines, of which plants are the important source. WHO recommends macroscopic and microscopic studies o...

Hema Nidugala, Ramakrishna Avadhani, Sunil Kumar Naraya , B. Bhaskar and Anupama Noojibail *

Associate Professor, Department of Physiology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2308-11

2308-2311

2000

440

32.

DESIRE FOR FERTILITY AND ASSOCIATED FACTORS AMONG PEOPLE LIVING WITH HIV/AIDS (PLWHA) IN SELECTED ANTIRETROVIRAL THERAPY (ART) CLINICS OF HORRO GUDURU WOLLEGA ZONE, NORTH WEST OROMIA, ETHIOPIA- A CROSS SECTIONAL STUDY

Background: Most recently fertility issues in HIV positive men and women are becoming increasingly important. Because of ART access and its good life effect, it is expected that the need and desire to get married, to have children and to have sexual partners for PLWHA would change with the regard to reproductive health. In Ethiopia HIV positive individuals may or may not have desire to have childr...

Reta Tsegaye Gayesa*, Daniel Mengistu and Carolyn Moorhead

Department of Nursing, College of health Sciences, Samara University , Samara, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2312-21

2312-2321

1541

473

33.

PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF AQUEOUS EXTRACT OF THE AERIAL PARTS OF VIBURNUM PUNCTATUM BUCH. – HAM. Ex. D. DON

The genus Viburnum punctatum Linn. Under the family Caprifoliaceae (formerly) and Adoxaceae (currently) consists of about 200 species throughout the world. Many of these species have been recognized for their medicinal properties from very early times of this century. The aerial parts of  Viburnum punctatum was collected from Nilgiri hills, Tamilnadu, India and was authenticated by Dr. A. B. Rema...

P.V. Susmitha*, V.B. Arunlal ,C.R. Biju and G. Babu

Nehru College of Pharmacy , Pampady P.O, Thrissur Dist., Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2322-26

2322-2326

1343

471

34.

FORMULATION AND EVALUATION OF ANTACID ANALGESIC TABLET

The present study deals with formulation of a combined analgesic and antacid effervescent tablets. Paracetamol is the model drug used. It is poorly soluble in the water and hence the formulation is in the form of an effervescent tablet so that the disintegration time of the drug is not hindering the action. The mixture of magnesium and aluminium hydroxide is used as the model antacid. The present ...

N.D. Banerjee*, S .S. Shukla and S.R. Singh

Dr. L.H. Hiranandani College of Pharmacy, CHM Campus, Ulhasnagar- 03, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2327-35

2327-2335

4105

1058

35.

POST-GRADUATE PHARMACY STUDENTS PERCEPTION ABOUT CHANGES REQUIRED IN PHARMACEUTICAL EDUCATION AND USE OF LEARNING MANAGEMENT SYSTEM IN SELECT COLLEGES IN SOUTH INDIA

A pilot study was conducted to understand the study habits of the post-graduation (PG) pharmacy students’ in India and their perspective on the use of a Learning Management System (LMS) in line with the current system of education to meet the industrial requirements in Indian scenario. The researchers administered of an open labeled, questionnaire to understand students’ study pattern, expecta...

A.A. Easow *, K. Kannan , H.R. ShobhaRani , K.N Sundaresh and H.S. Shekar

Al-Ameen College of Pharmacy , Near Lalbagh main gate, Hosur road, Bangalore- 560 027, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2336-50

2336-2350

1687

632

36.

ASSESSMENT OF JOB SATISFACTION AMONG PHARMACY PROFESSIONALS IN SOUTH- WEST ETHIOPIA

Background: Job satisfaction represents one of the most complex areas facing today’s managers when it comes to managing their employees.  The level of job satisfaction among pharmacy personnel is of importance because it may affect performance and retention. Objective: To assess the level of job satisfaction and factors associated with it among pharmacy professionals working at selected heal...

Seid Mussa Ahmed*, Muluken Tolera and Mulugeta Tarekegn Angamo

Makkah Community College, Umm AL-Qura University, Makkah, Saudi Arabia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2351-58

2351-2358

2353

574

37.

EVALUATION OF WOUND HEALING ACTIVITY OF LEAF EXTRACT OF DODONAEA VISCOSA JACQ INALLOXAN INDUCED DIABETIC WISTAR ALBINO RATS

The present study was undertaken to evaluate the wound healing activity of leaf extract of Dodonaea viscosa Jacq in diabetic wistar albino rats. Wound is defined as a loss or breaking of cellular and anatomic or functional continuity of living tissue. Normal wound healing response begins the moment the tissue is injured. Wound healing is the process of repair that follows injury to the skin and ot...

S.S. Pawar* and H.B. Mahajan

Sinhgad Technical Education Society’s, Smt. Kashibai Navale College of Pharmacy, Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2359-63

2359-2363

1589

706

38.

HOMOLOGY MODELING AND DOCKING STUDIES ON HIV REVERSE TRANSRIPTASE INHIBITORS

The usefulness of computational methods in drug design process is no longer a point of debate. The contributions from this evolving field have become apparent to both pharmaceutical scientists and academic biomedical researchers. As all the computational drug design are based on statistical and mathematical calculations there is strong evidences present for each and every step, thus research by ch...

T.B. Kakade

College of Pharmacy, Medha, Satara, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2364-83

2364-2383

1564

469

39.

CLINICOPATHOLOGICAL STUDY OF 115 CASES OF GLIOBLASTOMA MULTIFORME WITH SPECIAL REFERENCE TO GLIOSARCOMA

Background: Glioblastoma Multiforme is the commonest of all astrocytomas. It accounts for 12-15% of all intracranial neoplasm and 50-60% of all astrocytic tumors. Most common site of occurrence is cerebrum and age incidence is highest in fifth and sixth decade. Gliosarcoma constitutes 2% of all brain tumors, 5% of all astrocytomas and 8% of anaplastic astrocytomas. The cell of origin of sarcomatou...

Manisha Khanna*, Pradeep Mendiratta and Subimal Roy

Department of Pathology, Shri Ram Murthy Smarak, Institute of Medical Sciences, Bhojipura, Bareilly, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2384-92

2384-2392

1536

394

40.

SYNTHESIS, CHARACTERIZATION AND PHYSICOCHEMICAL STUDIES OF Ni(II) AND Cu(II) COMPLEXES WITH SOME NITROGEN- OXYGEN AND NITROGEN SULPHUR DONOR LIGANDS

Ni(II) and Cu(II) complexes of Schiff base thiosemicarbazones (L1) and semicarbazones (L2) derived from pyrrole-2-carboxaldehyde. These complexes are characterized by elemental analysis, molar conductance measurements, magnetic suscepectibility measurements, mass, IR, electronic and EPR spectral studies. The molar conductance measurements of the complexes in DMSO determine the non-electrolytes and...

Sulekh Chandra* and Prem Ballabh

Associate Professor, Department of Chemistry Zakir Husain Delhi College University of Delhi, J.L.N. Marg New Delhi-110002, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2393-99

2393-2399

1725

553

41.

A VALIDATED RP- HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND DICYCLOMINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

A reversed-phase-liquid chromatographic (RP-HPLC) method was developed for the determination of Paracetamol (PCM) and Dicyclomine Hydrochloride (DICY) in their bulk drug and marketed formulations. A reversed-phase C-18 Phenomenex C18 column (250 mm × 4.6 mm i.d., 5μm) with mobile phase consisting of Acetonitrile: Phosphate Buffer pH (5.5): triethylamine (75:25:0.02 v/v/v) was used with 1.0 ml/ m...

Roshni J. Hedpara*, Vibhuti Chhatarala and Ashwin Agola

Department of Quality Assurance, N. R. Vekaria Institute of Pharmacy, C. L. College Campus, Bilkha Road, Junagadh-362001, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2400-05

2400-2405

2500

779

42.

STABILITY INDICATING HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHIC DETERMINATION OF QUETIAPINE FUMARATE

A simple, sensitive, selective, precise and stability indicating high-performance thin-layer chromatographic method for determination of quetiapine fumarate both as a bulk drug and from tablets was developed and validated as per the International Conference on Harmonization (ICH) guidelines. The HPTLC method employed aluminum plates precoated with silica gel G 60F254 as stationary phase. The solve...

Zarna R. Dedania*, Navin R. Sheth and Ronak R. Dedania

Bhagwan Mahavir College of Pharmacy 1, Nr. Ashriwad Villa, B/H Heena Banglows, Bharathana- Vesu, Surat- 395017, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2406-14

2406-2414

1768

853

43.

EFFECT OF LIGHT AND HEAT ON STABILITY OF CRUDE CAROTENOID EXTRACT FROM NATURAL SOURCES

Carotenoids are accessory coloring pigments found occurring naturally in the plants and some photosynthetic organisms.  Recently there has been an increased focus on the health benefits and food applications of these natural pigments. The stability and bioavailability of carotenoids vary significantly across a range of processing paradigms. The present study was planned to investigate stability o...

Sumita S. Kadian*, Alka Sharma and D.R. Sood

Department of Food Technology, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2415-18

2415-2418

4950

719

44.

COMPARATIVE STUDY OF EFFECTS TWO β2 ADRENERGIC AGONISTS ON BIOCHEMICAL PARAMETERS IN MODERATE TO SEVERE BRONCHIAL ASTHMA PATIENTS

Background: β2- agonist drugs are frequently prescribed in asthmatics. Apart from bronchodilation they affect biochemical and physical parameters of the body. Method:  Total 80 patients were divided into two groups. Group I (n=40) received Albuterol- 2.5mg./2.5ml. TDS and Group II (n=40) received Levalbuterol- 0.63mg./2.5ml, TDS via nebulizer for 4 weeks. Baseline and post-treatment estimatio...

Kavita Rathore , Neha Sharma*, M.L. Aseri , Sunil Kumar Mathur and Sanjay Sankhla

Department of Biochemistry, SRMS-IMS, Bareilly- 243202, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2419-26

2419-2426

2803

582

45.

DESIGN, FORMATION AND EVALUATION OF A CO-DRIED DIRECTLY COMPRESSIBLE EXCIPIENT “TSAG-15” AND ITS UTILIZATION IN THE FORMULATION OF A RAPID RELEASE-MOUTH DISINTEGRATING ASCORBIC ACID TABLETS

A research was conducted to design a directly compressible filler binder characterized with rapid release and mouth disintegrating. Acacia gum was obtained from local source and was purified using a standard method. Tapioca starch was also extracted from cassava tuber using a standard method. Both primary excipients were evaluated for power properties and coprocessed at varying concentration using...

A.O. Shittu*, C. C. Yakubu, A.B. Isah and A.R.Oyi

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2427-34

2427-2434

1449

452

46.

SIMULTANEOUS ESTIMATION OF DICLOFENAC SODIUM AND ESOMEPRAZOLE MAGNESIUM TRIHYDRATE IN BULK DRUG AND IN SYNTHETIC MIXTURE BY SPECTROPHOTOMETRY

Two simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous estimation of Diclofenac Sodium (DIC) and Esomeprazole Magnesium Trihydrate in bulk drugs and synthetic mixture. Method A, Simultaneous equation method (Vierodt’s method) applies measurement of absorptivities at two wavelengths, 280.00 nm, (λmax of Diclofenac Sodium) and 301.00 nm,( (λmax of...

Darshan Gohil and S.J. Rajput*

Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System, Pharmacy Department, The Maharaja Sayajirao University of Baroda, Fatehgunj, G. H. Patel Building, Donor’s Plaza, Vadodara – 390 002, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2435-40

2435-2440

1444

529