Volume 12 (2021) - Issue 8, August
Cancer initiates from the transformation of normal living cells into malignant cells via a multistage event that usually advances from a pre-cancerous phase to a malignant tumour. Anti-metastatic drugs or anti-neoplastic drugs prevent and regulate the growth of onco cells. Based on the mode of drugs, the universally anticancer drugs market is categorized into cytotoxic, targeted, and hormonal drug...
In global debates, traditional herbal medicines are getting a lot of attention, especially in the treatment of Epilepsy. This deadly disease is estimated to affect around 50 million people around the world. This neurological disorder is believed to be due to excessive electric discharge in the brain and the release of neurotransmitter substances. Antiepileptic drugs are useful but are expensive an...
SCREENING OF MEDICINAL PLANTS USED FOR PREVENTION AND TREATMENT NEURODEGENERATIVE DISEASES: A REVIEW
Amyotrophic lateral sclerosis (ALS), Parkinson's disease, Alzheimer's disease, and Huntington's disease occur as a result of the neurodegeneration process. No specific treatment was found to reduce or stop neurodegenerative diseases. In conventional medicine, many plants have been used to treat neurodegenerative diseases. Natural products play an important role in the prevention and treatment of v...
Euphorbia fusiformis Buch.-Ham.ex D. Don, (Synonym: Euphorbia acaulis Roxb) is an infrequent, medicinal, geophytic herb of the family Euphorbiaceae. It is distributed only in few pockets of India, Nepal, Africa and China. In India, it is found to grow in Maharashtra, Karnataka, Gujarat, Goa, Rajasthan, Andhra Pradesh, Madhya Pradesh, Uttar Pradesh, Bihar, Tamil Nadu and West Bengal. Traditionall...
Momordica charantia and Momordica dioica species belong to the Cucurbitaceae family. Momordica charantia and Momordica dioica climbing creeper plants are used both in the prevention and cure of various diseases and in the food of humans. Momordica charantia is also known as bitter gourds, bitter melon, karela, and balsam pear. Momordica charantia contain phytochemical constituents such as alkaloid...
Cancer is a serious health concern in both developed and developing nations. Cancer causes due to unwanted growth of cells and irregular cell division. Medicinal plants have been used by village folk from ancient times. The plants contain various bioactive compounds that can be used for treating cancer. Some of the phyto compounds isolated from plants have shown promising results; these include ...
The Elettaria Maton genera belonging to the Zingiberaceae family is native to South India to West Malesia. From ancient times this genus has been largely explored for its biological properties. Various pharmacological properties such as anti-inflammatory, analgesic, antioxidant, and antimicrobial effects have been related to this genus. E. cardamomum also acts as an Ayurvedic aphrodisiac and remed...
Andrographolide is a labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata Nees (Acanthaceae). Andrographolide is isolated by various processes and the simple method is the maceration process. It is bitter in taste and used as hepatoprotective, cholinergic, antispasmodic, stomachic, anthelmentic, alterative, blood purifier, and febrifuge. It promotes the secretion of bi...
Background: World Health Organization states that antibacterial/antimicrobial resistance (AMR) can threaten the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi. Objective: This review aims to discuss the plants and their derivatives having anti-corona virus/ viral activity. Methods: For the preparation of this review ar...
The medicinal plant Citrullus colocynthis is very significant for indigenous medicine. The pharmacological effects of root, fruits, seeds, leaves, and the whole C. colocynthis have been practices for the treatment of diseases. Phytochemical screening of the fruits of C. colocynthis has observed several bioactive compounds. The glycosides, flavonoids, alkaloids, carbohydrates, fatty acids, and esse...
CYTOTOXIC AND ANTIPROLIFERATIVE STUDIES OF ISOCORDOIN AND SOME DERIVATIVES AGAINST PROSTATE CANCER CELL LINES
The proposed study was to evaluate the in-vitro cytotoxic and antiproliferative activities on prostate cancer cell lines of isocordoin (1) and 2’,4’-dihydroxy-3’-(g,g-dimethylallyl) dihydrochalcone (2), chalcones isolated from roots of Lonchocarpus xuul Lundel, together with four analogues of 1. Isolation of compounds 1 and 2 from L. xuul roots and chemical modification were in accordance wi...
ANALGESIC ACTIVITY AND PHYTOCHEMICAL PROFILE OF AQUEOUS, ETHANOL AND DICHLOROMETHANE EXTRACTS OF PERSEA SCHIEDEANA LEAVES
Traditionally Persea schiedeana is used for headache relief, as anti-hypertensive, nervous relaxant, dermal diseases, among others. In this study, this plant from Salvadorian flora acute toxicity was evaluated in-vivo at 500 mg/kg, and the analgesic activity was tested by acetic acid, formalin, and tail flick tests in NIH Swiss mice at doses of 100, 250, and 500 mg/kg body weight, using as a posit...
ANALYSIS OF THE EFFECT OF LOW DOSE DOPAMINE IN TREATMENT OF PRERENAL AZOTEMIA IN ADULT PATIENTS ATTENDING NEPHROLOGY UNIT IN NAUTH, NNEWI, NIGERIA
Background: This was a conventional comparative treatment-controlled study designed to analyze the effect of dopamine infusion in the treatment of prerenal azotemia (PRA). Material and Methods: thirty randomized consecutive adult patients (group A= 15, B=15) aged 18 and 58 years with PRA were recruited. Group a received conventional treatment only (fluid replacement and frusemide), while group B r...
DESIGN AND EVALUATION OF CHRONOTHERAPEUTIC ANTI-HYPERTENSIVE COMBINATION THERAPY USING MINI-TABLETS TECHNOLOGY
Hypertension or elevated blood pressure (BP) is a serious medical condition that significantly increases the risks of heart, kidney, brain, and other diseases. In persons with normal BP and uncomplicated essential hypertension, BP falls to the lowest levels during the nighttime sleep, and rises suddenly with morning awakening, and reaches the peak during the initial h of diurnal activity. The opti...
STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF REMOGLIFLOZIN ETABONATE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY RP-HPLC
An accurate, precise, and simple stability-indicating and RP-HPLC method was developed and validated for the estimation of Remogliflozin Etabonate in bulk and pharmaceutical dosage forms. Primacel C18 (150 × 4.6mm, 5µm) column, with mobile phase Acetonitrile: Water (70:30, v/v) at isocratic mode, was used for the development of this method. At wavelength 280nm, and flow rate of 1ml/min was maint...
Niosomes are vesicular carriers in the drug delivery system that are reported in the seventies. They are formed by self -assembly of non –ionic surfactant and cholesterol upon hydration with aqueous media resulting in lamellar structures that encapsulates both polar and non polar drugs. In the present research work, Montelukast sodium niosomes were prepared by using non –ionic surfactant span ...
MOLECULAR MODELING STUDIES OF NOVEL N-(3-(BENZO[D]THIAZOL-2-YL)-4-((SUBSTITUTED BENZYL) OXY)PHENYL) ACETAMIDE AS EGFR INHIBITORS
Background: Cancer is continuing to be a major health problem in developing as well as undeveloped countries. It is a leading cause of mortality worldwide, accounting for most of the deaths. Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, and mutations that lead to EGFR overexpression or overactivity have been associated with a variety of human cancers. Purpose: In-silico ...
Colon carcinogenesis is a multistep process that arises by the accretion of genetic alterations. The genetic and epigenetic changes which transform normal colonic epithelium into aberrant crypt foci which is responsible for penetration. The GC-MS analysis of ethanolic extract of Epiphyllum oxypetalum (DC.) have shown the presence of phenolic compound (4-hydroxy-2-methylacetophenone), Diterpen...
HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF CAYRATIA PEDATA VAR. GLABRA AGAINST PARACETAMOL-INDUCED LIVER DAMAGE IN ALBINO RATS
The present pharmacological examination was purely focused on the assessment of the efficacy of ethanolic extract of C. pedata var. glabra for their protection against Paracetamol overdose-induced hepatotoxicity arbitrate with their phytoconstituents and also observe whether synergistic hepato-protection exists with Silymarin. For animal studies, the Albino rats (150–200 g) were divided into six...
Support of the useful medicinal properties of different native plants has gained huge significance as they can be used as a substitute source of lead compounds in pharmacological industries to begin many modern-day problems such as drug resistance in microorganisms and non-specificity in chemotherapeutic agents. Amischophacelus axillaris is one such plant that has been widely used for medical purp...
Distinctive groups of fungi are involved in the symbiotic association with epiphytic orchid. We have isolated endophytic fungi from Cleisostoma tenuifolium epiphytic orchid found in the Western Ghats and used morphological criteria as well as molecular techniques to identify these fungi. Characterization of these fungi was done by analyzing the quantified genomic sequences, and then identification...
Background: Scorpionism is an endemic and highly prevalent public health predicament causing severe cardio or neurotoxic effect. Ayurveda proposes a range of medicinal preparations (internal & external) in the management of Vrishchika Damsha (Scorpion sting). Among them, Hingwadi and Jeerakadi lepa are topical anti-inflammatory medications, and Bilwadi Gutika is a potent vishahara medicine (Al...
GREEN SYNTHESIS OF SILVER NANOPARTICLES USING SAUROPUS ANDROGYNOUS LEAF EXTRACT WITH POTENTIAL BIOLOGICAL PROPERTIES
Nanoparticles are being constantly exploited by the scientific community due to their versatile properties and applications. However, the synthesis of metallic nanoparticles achieved through conventional physical and chemical techniques is quite expensive and a labor-intensive process with serious consequences like instability of nanoparticles and toxic byproducts. Hence, green synthesis utilizing...
PHYTOCHEMICAL AND IN-VITRO ASSESSMENT OF ANTIHISTAMINIC AND ANTICHOLINERGIC ACTIVITY OF LEAVES OF HIBISCUS SABDARIFFA LINN.
Objective: The aim of the present study was to find out the herbal drug which has potential antihistaminic properties. Studying the in-vitro antagonistic effect of crude extracts on isolated goat tracheal chain preparation for assessment of direct antihistaminic activity using two agonists like histamine and acetylcholine. Methods: The ethanolic extract of leaves of Hibiscus sabdariffa was found q...
COMPARATIVE EVALUATION OF FOUR MEDICINAL PLANTS FOR TOTAL PHENOLS, FLAVONOIDS, IN-VITRO ANTIOXIDANT AND ANTI-HEMOLYTIC ACTIVITIES FOR THERAPY
Antioxidants from plant sources have gained acclaim as an excellent source for living a healthy life in recent times. The present study investigates comparative quantitative characterization of phytochemicals, in-vitro antioxidant and anti-hemolytic activities among aqueous and ethanolic extracts of four Indian medicinal plants viz. Berberis aristata, Cedrus deodara, Vitex negundo and Tinospora co...
Enzymatic browning is a process that occurs in fruits and vegetables by the enzyme polyphenol oxidase, which results in brown pigments reduce shelf life which indirectly causes huge domestic loss to the farmers during the post-harvesting process. In this context, the present study was carried out to preserve and increase the shelf life of Brinjal vegetables from enzymatic browning using ascorbic a...
In Ayurveda, ghrita (ghee) and taila (oil) are commonly used for treatment either internally or externally. It is commonly believed that by consumption of oil or ghee will lead to hyperlipidemia. Hyperlipidemia is an ailment of lipid metabolism produced by an increase of plasma concentration of the various lipid and lipoprotein, which cause cardiac disease, premature coronary artery disease, strok...
EFFECT OF COPPER NANOPARTICLES ON IN-VITRO SEED GERMINATION OF WHEAT (TRITICUM AESTIVUM L.) VARIETIES
The comparative study of in-vitro seed germination was conducted to determine the influence of different concentrations of chemically synthesized copper nanoparticles (CuNPs) on the in-vitro seed germination and growth of two different varieties of wheat- PBW677 and PBW725 on MS medium. For all growth parameters taken under the present study, PBW 725 variety of wheat performed better in the basal ...
PREVALENCE OF URINARY TRACT INFECTIONS AND RELATED ANTI-MICROBIAL RESISTANCE IN INDIA: A SYSTEMATIC REVIEW AND META-ANALYSIS
Background: Urinary Tract Infections (UTIs) are one of the most commonly occurring infections in medical practice despite the widespread availability of antibiotics. This study aims to ascertain the prevalence of uropathogens and determine their antibiotic susceptibility or resistance patterns in the Indian population. Methods: A thorough search on the research studies concerning UTIs and their an...
IN-VITRO BIOACTIVE POTENTIAL OF ENDOPHYTIC FUNGI CURVULARIA LUNATA ISOLATED FROM MEDICINAL PLANT FICUS RELIGIOSA
Several studies undertaken in the recent past have demonstrated that endophytic fungi are capable of producing a number of important bioactive secondary metabolites, hitherto known only from plants, thereby raising the potential of using endophytes as alternative sources for these metabolites. Occasionally, the compounds produced by endophytic fungi are similar to those produced by the respective ...
The solubility, dissolution, and gastrointestinal permeability are the prime factors for drug absorption. Rifaximin is a structural analogue of rifamycin that inhibits RNA synthesis by binding to β-subunit of bacterial DNA-dependent RNA polymerase. Rifaximin is a class 1V drug having low solubility and low permeability. My theme of the design is to develop the technological characterization of do...
ALPHA-AMYLASE INHIBITORY ACTIVITY OF KATANKATERYADI KWATHA (K. KWATHA) IN MANAGEMENT OF TYPE 2 DIABETES
Objectives: The objective of the study is to find out the alpha-amylase inhibitory activity of Katankateryadi Kwatha. The alpha-amylase enzyme is the key source for postprandial hyperglycaemia, which is responsible for Type 2 Diabetes. Methodology: The crude drugs of Katankateryadi Kwatha (K. Kwatha) were collected from a local market. The Kwatha was prepared and dried with rotatory evaporator, un...
A NOVEL APPROACH TOWARDS GREEN SYNTHESIS OF ZINC NANOPARTICLES FROM BANIUM PERSICUM AND ITS PHARMACOLOGICAL EFFICACY
Integration of nano-science in medicine leads to the development of biomedical products that help society in a faster and safer manner. In the present studies, Zinc nanoparticles were synthesized by green synthesis route using aqueous extracts of Banium persicum, and characterization was done through UV, SEM, TEM, FT-IR, and XRD. The synthesized nanoparticle was spherical in shape with an average ...
The current work comprises the assessment of antidiabetic activity of chloroform, ethyl acetate, and ethanol fractions and isolation of some phytoconstituents from chloroform fraction obtained from ethanolic extract of Echinochloa colona. The antidiabetic activity was performed using streptozocin induced diabetic model in male Wistar rats (150-200 g). The best restraint results were for metformin,...
IDENTIFICATION AND OPTIMIZATION OF BINDING SITE FOR AN ACTIVE METABOLITE OF CLOPIDOGREL, PRASUGREL AND TICLOPIDINE ON RECEPTOR P2Y12
In this article, an attempt was made to develop molecular docking studies on active metabolites of Prasugrel, Clopidogrel, and Ticlopidine acting as protein P2Y12 inhibitors. Molecular docking analysis was performing by using autodock version 4.3 adjoin with discovery studio to better understand the interactions between P2Y12 targets and inhibitors in this series. Hydrophobic and hydrogen bond int...
The plant Scoparia dulcis Linn. belongs to the family Scrophulariaceae, is a native of tropical America, commonly called a sweet broom. The traditional healers identified its uses as anti-diabetic, antipyretic, antihypertensive, diuretic, and they have developed many promising traditional medicines and formulations from this plant. The main objective of this present study reveals about the phytoco...
EVALUATION OF TOTAL POLYPHENOLIC CONTENT AND FREE RADICAL SCAVENGING ACTIVITY OF ETHANOLIC AND AQUEOUS EXTRACTS OF CORDIA OBLIQUA FRUITS
The present study was carried out to investigate the phytochemicals, Total polyphenolic content and In-vitro antioxidant activity of ethanolic and aqueous extracts of Cordia obliqua fruits. Objective: To determine the primary and secondary metabolites present in different extracts, to aces the quantity of phenolic compounds by total phenolic content and to evaluate the % inhibition of free radical...
CORRELATION ANALYSIS OF PHYTOCHEMICALS AND ANTIOXIDANT ACTIVITIES OF HELIOTROPIUM INDICUM L. LEAVES EXTRACTS
The present study aimed to investigate the correlation between the total phenolic and flavonoid contents and in-vitro antioxidant activity of the Soxhlet-extracted leaves extracts (hexane, chloroform, ethyl acetate, methanol and aqueous) of Heliotropium indicum L, a medicinal weed. The preliminary phytochemical analysis was carried out in all five solvents using the standard methods of Harbonne. T...
The present study was aimed to evaluate the effect of Piperine on the antidiarrhoeal activity of Diphenoxylate. Antidiarrhoeal effect of Diphenoxylate, Piperine and Diphenoxylate in combination with Piperine was subjected to pharmacological evaluation. Antidiarrhoeal effect was evaluated in castor oil and magnesium sulphate induced diarrhoea model while antimotility and antisecretory effect was ev...
Oral squamous cell carcinoma (OSCC) is the most commonly occurring malignancy of the oral cavity. Over the years, the incidence and morbidity rate of Oral Cancer patients has increased worldwide. In the last few decades, although oral cancer treatment modalities have advanced, the survival rate of oral cancer patients is very low. Thus, there arises a need for the identification of new drug target...
Previous studies investigated the host-derived salivary matrix metalloproteinases (MMPs) are responsible for dentin caries progression. The utilization of the MMP inhibitors can become a successful strategy to control dentin caries. In this study, we have tested twenty-four different medicinal plant leaf extracts against human salivary MMPs for investigation of inhibitors. Total phenolics were ext...
The objective of this current work is to develop the formulation and evaluation of a subcutaneous drug delivery system based on diclofenac sodium microemulsion. A different formulation has been formulated using a modifying amount of gelling agent and a penetration enhancer. Pseudo ternary phase diagrams were constructed for different microemulsion formulations composed of the formulations FEG1, FE...
The present paper deals with the pharmacognostical and phytochemical investigation of Fumaria parviflora Lam. whole plant. The qualitative and quantitative phytochemical analysis was carried out for the important bioactive constituents present in Fumaria parviflora Lam. (whole plant) in its Hydroalcoholic extract. The preliminary phytochemical analysis showed the presence of alkaloids, phenols, fl...
FORMULATION AND IN-VITRO EVALUATION OF GASTRO RETENTIVE FLOATING TABLET OF VENLAFAXINE HYDROCHLORIDE BY HOT-MELT EXTRUSION METHOD
Drugs that have a proximal absorption window can be improved by the Gastro Retentive Drug Delivery System which provides continuously releasing the drug for a prolonged period of time as controlled delivery before it reaches its absorption site, thus ensuring its optimal bioavailability. The intend of this current work is to formulate a gastro retentive floating tablet of Venlafaxine hydrochloride...
ANTIMICROBIAL ACTIVITY OF INSTANT COFFEE AGAINST SOME MULTI-DRUG RESISTANCE BACTERIA AND PATHOGENIC FUNGI
This paper presents the antimicrobial activity of instant coffee, a prevalent beverage utilized by millions of people worldwide every day. Several studies have shown that instant coffee contains many useful bioactive compounds, the most important: caffeine, trigonelline, chlorogenic acid, ferulic acid, caffeic acid, nicotinic acid, and phenolic compounds which are responsible for the antimicrobial...
High-Performance Liquid Chromatography is an important and powerful analytical technique for the identification, quantification and isolation of natural products. In the present investigation, a Reversed-Phase- HPLC method was developed for the identification and quantification of the marker compound quercetin in Euphorbia thymifolia Linn. (whole plant) and Manilkara hexandra Roxb. (leaves). Both ...
EFFECT OF STARCH ISOLATION METHODS ON CHEMICAL, FUNCTIONAL AND STRUCTURAL PROPERTIES OF PEARL MILLET STARCH (PENNISETUM TYPHOIDIUM)
The study was carried out to determine the chemical, functional, and structural properties of starch that was isolated by various methods from pearl millet (Pennisetum Typhoidium). Isolation methods of starch with different chemicals influenced starch properties. Pearl millet starch was isolated by Sodium azide (alkaline) (T1), Sodium metabisulfite & lactic acid (T2) (neutral), and Mercuric ch...
HEPATOPROTECTIVE EFFECTS OF POLYHERBAL FORMULATION AGAINST CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY IN ALBINO RATS
Objective: To investigate the hepatoprotective activity of polyherbal formulation composed of extracts of Bauhinia variegata, Oxalis corniculata, and Pterocarpus marsupium. Methods: The hepato-protective activity of the formulation and extracts were assessed on the basis of histopathological changes in the liver and estimation of SGOT, SGPT, SALP, serum bilirubin of carbon tetrachloride-induced he...
The present study aimed at comparing the antioxidant potential of three different samples of Eclipta alba-fresh plant, marketed leaf powder (packaged in sealed containers), and marketed whole plant (sold in open bags). The presence of alkaloids, saponins, triterpenes, terpenoids, tannins, steroids, flavonoids, glycosides was confirmed in all three samples. Fresh plant samples showed a higher antio...
SYNTHESIS AND DNA PHOTOCLEAVAGE ACTIVITY OF LANTHANUM AND NICKEL COMPLEXES OF PYRAZOLYL BISCOUMARIN DERIVATIVES
Hybrid molecules, furnished by combining coumarin and pyrazoles, have been synthesized in the present study. In addition, the binding ability of these coumarin-based molecules has been investigated for Nickel and less studied lanthanum. Lanthanum and nickel complexes with 4-hydroxy-3-((4-hydroxy-2-oxo-2H-chromen-3-yl)(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)-2H-chromen-2-one (4a) and 4-h...
SYNTHESIS, IN-VIVO ANTI-INFLAMMATORY EVALUATION AND MOLECULAR DOCKING STUDY OF A SERIES OF SUBSTITUTED XANTHONE DERIVATIVES AS NOVEL COX-2 INHIBITORS
A series of 3,6-bis (3/-substituted propoxy) and 3,6-bis (5/-substituted pentyloxy) xanthone derivatives was synthesized by the condensation of 3,6-bis (3/- bromopropoxy) and 3,6-bis (5/-bromopentyloxy) xanthones with primary or secondary amines. These compounds were characterized by FT-IR, 1H NMR, and Mass spectral data. The anti-inflammatory study of the synthesized compounds was carried out usi...
THE RADIO-PROTECTIVE EFFECTS OF WITHANIA SOMNIFERA AGAINST MOBILE PHONE ELECTROMAGNETIC RADIATION-INDUCED INFERTILITY IN MALE WISTAR RATS
Introduction: The study was aimed at knowing the effect of mobile phone electromagnetic radiation (EMR) on fertility in Wistar Albino Rats and to assess the capability of polyphenolic rich Withania somnifera root extract in shielding rat testis against EMR-induced injuries. Methodology: One hundred and forty-four male Wistar Albino Rats were included in the study and grouped in to 4. Group I recei...
PREVALENCE AND KNOWLEDGE ABOUT OVER THE COUNTER (OTC) MEDICINE USE AMONG PREGNANT WOMEN IN THE ASIR REGION OF SAUDI ARABIA
Self-medication with OTC drugs is observed in many countries and deserves due concern as it may adversely affect maternal and fetal health. This practice may have an association with socio-demographic factors and knowledge about OTC medicine. A descriptive study was done using a questionnaire that collects information on socio-demographic status, prevalence and knowledge of OTC medicine use among ...
NEWER VACCINE INTRODUCTION (PNEUMOCOCCAL CONJUGATE VACCINE) FROM THE STATE’S OWN RESOURCES IN HARYANA, INDIA: AN EXAMPLE OF ADVOCACY TO POLICY AND ACCELERATED PUBLIC HEALTH ACTION
Introduction: Global pneumonia mortality (50%) caused by pneumococcus is responsible for invasive pneumococcal disease. Pneumococcal Conjugate Vaccine (PCV) has been introduced by the Government of India in a phased manner in selected states, but Haryana was not included. Objective: To draw key lessons learned from the process of newer vaccine introduction (PCV) in Haryana from the state’s resou...
BREAD FRUIT LEAF EXTRACT COMPOSITION AND ITS EFFECT ON OXALATE AND LEUKOCYTE PROFILES IN HYPEROXALURIC RATS INDUCED BY ETHYLENE GLYCOL
Nephrolithiasis or kidney stone disease is a disease characterized by the formation of crystals in the kidney. It is a disease that is found in many countries with high rates of recurrence and treatment costs. This study analyzes the effect of Breadfruit leaf extract on oxalate levels of CaOx stones deposited in the kidney and leukocyte differentiation in hyper oxaluric rats induced ethylene glyco...
ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF NEW TRANSITION METAL COMPLEXES DERIVED FROM 5-(2-(4-METHOXYPHENYL)-1H-BENZO [D] IMIDAZOL-1-YL) QUINOLIN-8-OL
New pharmacologically active transition metal complexes of Co(II), Ni (II), Cu (II), and Zn(II) have been synthesized with the ligand 5-(2-(4-methoxyphenyl)-1H-benzo [d] imidazol-1-yl) quinolin-8-ol (2). Different analytical and spectroscopic tools were used to analyze the compounds, including elemental analysis, FTIR, 1H-NMR, mass spectra, electronic spectra, magnetic measurement, and molar condu...
Pouzolzia zeylanica (L.) Benn. is a medicinal plant widely found in the Asian continent, including the North Eastern (NE) region of India. The plant is being used for its various medicinal properties against wide range of disease conditions as folk medicine in Assam and various places. A research was designed to carry out an evaluation of anti-arthritic activity of the leaves of Pouzolzia zeylanic...