Volume 2 (2011) - Issue 1, January
Female infertility is the major disorder which has altered the man kind foe lack of conception and reproducibility, stressful world, excess radiation, lack of biological food, genetically disorder ,changing life style, increased electronic discharge have resulted the female infertility. Infertility/ childlessness cause great personal suffering & distress. Most of this agony & misery is hid...
Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for ...
The aim of the present study was to carry out phytochemical screening and anticonvulsant activity of various extracts of the whole parts of Wedelia chinensis. The extracts (Petroleum ether, Ethanolic & Aqueous) were subjected to various chemical tests in order to identify the main phytoconstituents of the plant. The results of the present investigation revealed that the ethanolic extract conta...
A PRELIMINARY EVALUATION OF ANTIBACTERIAL AND TOXIC POTENTIALS OF P. GUINEENSE SWARTZ. FRUIT PULP FROM DIFFERENT STAGES OF RIPENESS
Psidium guineense Swartz is a shrub native to Brazil. It is consumed in natura or in the form of pulp, which presents a high content of C vitamin and proteins. The chemical prospection of the aqueous extracts from unripe and mature pulp revealed the presence of tannins and flavonoids. The extracts demonstrated moderate antibacterial activity against the most of strains tested, and the best result ...
Nigella sativa L. (Black cumin) has showed a broad spectrum of pharmacological effects like antipyretic, analgesic, anti-inflammatory and antimicrobial. These activities may be related to the seeds oil. The most important chemical composition of hexanic extract of seeds was unsaturated fatty acids and essential oil. In this investigation the hexanic extract of seeds was topically applied to evalua...
Recent studies have provided relevant scientific support for the use of C. membranaceus root in the treatment of prostate cancers. In the current study, we formulated both liquid and solid oral dosage forms from the ethanol extract of C. membranaceus root and investigated their physicochemical properties, release effects and suitability in comparison with the currently used aqueous decoctions and ...
The purpose of this study was to improve the solubility of poorly soluble Carbamazepine by using solid dispersion technique utilizing common pharmaceutical polymers. The formulations were prepared with HPMC, PVP K30, and poloxamer 407 as polymers and methanol as solvent. The formulations were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, in vitro diss...
EXTRACTIVE VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF CHLOROQUINE IN PHARMACEUTICAL AND BIOLOGICAL MATERIALS
Extractive visible spectrophotometric method is described for the analysis of chloroquine in it pure forms, pharmaceutical dosage forms and biological materials. Linearity, precision, stability and accuracy were evaluated according to the recommended validation procedure. In the described method a drug complex was formed with cobalt thiocyanate reagent, buffered and extracted into nitrobenzene and...
ISOLATION OF ENDOPHYTIC FUNGI FROM DIPTEROCARPUS GRANDIFLORUS BLANCO AND EVALUATION OF XYLANASE ENZYME ACTIVITY FROM FERMENTATION BROTH
Xylanase enzyme, one example of secondary metabolites generated by the endophytic microbes was an enzyme which degrades Xylan. The current research study was focused on isolation of endophytic fungi from Dipterocarpus grandiflorus Blanco that produced xylanase enzyme and evaluation of this enzyme activity. Isolation of endophytic fungi from Twigs of D. grandiflorus Blanco were performed via direct...
Objective: To establish does response relationship to the hypertensive patients and ensure safety profile of drugs through counseling of patients. Method: Patients who have suffered by secondary hypertension with blood pressure range of above 145-170/100-110 mmHg are selected and divided in two groups. First group of patients to administer for Nifedipine 5mg and furosemide 40mg administered for...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD TO DETERMINE URSODEOXYCHOLIC ACID IN PHARMACEUTICAL DOSAGE FORMS
This study describes development and subsequent validation of a reversed phase high performance liquid chromatographic (RP-HPLC) method for the estimation of ursodeoxycholic acid used to solubilize cholesterol gallstones, in conventional tablet dosage formulation and in prepared dosage form. The chromatographic system was achieved in a BDS Hypersil C8 column (Thermo, 250mm x 4.6 mm, 5 µ) with an ...
Dissolution rate enhancement of alprazolam, an anti-anxiety drug, was done by preparing solid dispersions by solvent evaporation method .Polyethylene glycol 6000 and Polyvinyl pyrrolidone k-30 were selected as carriers. Drug: Polymer ratios were taken as 1:1,1:2and1:4 for both the polymers for the preparation of solid dispersions. Tablets were prepared from solid dispersions and also from physical...
FORMULATION AND CHARACTERIZATION OF BAMBUTEROL HYDROCHLORIDE FAST DISSOLVING TABLET USING VARIOUS SUPERDISINTEGRANTS
Bambuterol HCl is a potent anti-asthmatic agent, act by stimulation through beta-adrenergic receptors of intracellular adenylcyclase. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. In the present study, an attempt has been made to prepare fast dissol...
EVALUATION OF ANTI- INFLAMMATORY ACTIVITY OF CAPPARIS GRANDIFLORA WALL. EX HOOK. F. & THOMSON IN RODENTS
Capparis grandiflora was used to treat diarrhoea and other infective disorders in folklore. The present study aims at evaluating the action of chloroform soluble fraction, ethanol soluble fraction and ether soluble fraction of the leaves of Capparis grandiflora against inflammatory diseases. The anti-inflammatory effects were investigated by employing acute inflammatory model i.e.; carrageenan-ind...
In the present study, eight organic solvents and aqueous extracts of Canavalia mollis leaves were screened for their phytochemical composition, anti bacterial and free radical scavenging activities. Among the different extracts tested, ethanol, methanol and acetone extracts showed significant antimicrobial and radical scavenging activities. The most susceptible microorganisms were found to be Esch...
Lornoxicam (chlortenoxicam) is a non steroidal anti- inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. It is available in oral and parental dosage formulation. Lornoxicam is a Yellow or slightly yellow powder. It is slightly soluble in water, soluble in hydrochloric acid, slightly soluble in methanol. A simple spectrophotometric method was ...
REVERSE PHASE HPLC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF MELOXICAM IN BULK AND PHARMACEUTICAL FORMULATION
Meloxicam (MEL) is an oxicam derivative and a member of the enolic acid group of non-steroidal anti-inflammatory drugs (NSAIDs). Most of the reported methods for HPLC analysis of Meloxicam are cumbersome, time-consuming and expensive. Reverse phase chromatographic analysis was performed on a C18 Hi Q Sil column with methanol–water- orthophosphoric acid (80:19.9:0.1 % v/v) at a flow rate of 1ml/m...
HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF NAPROXEN SODIUM AND SUMATRIPTAN SUCCINATE IN PHARMACEUTICAL DOSAGE FORM
A rapid and simple high performance thin layer chromatography (HPTLC) method with densitometry at 230 nm was developed and validated for simultaneous determination of Naproxen sodium and Sumatriptan succinate from pharmaceutical preparation. Separation was performed on aluminum-backed silica gel 60F254 HPTLC plates as stationary phase and using a mobile phase comprising of methanol:distilled water...
IN-VITRO EVALUATION OF ANTIOXIDANT ACTIVITY AND TOTAL PHENOLIC CONTENT OF TYLOPHORA INDICA (BURM F.) MERILL
Tylophora indica is a perennial climbing plant native to India, found in plains, forests, hills of southern and eastern India. The portions of plant used medicinally are leaves. The Total phenolic content of methanolic leaves extract was estimated by Folin-Ciocalteu assay method, and was found to be 0.160 mg/CE/g (Catechine Equivalent per gram). However, antioxidant activity of methanolic leaves e...
Antipyretic effect of petroleum ether and chloroform soluble fractions of ethanol extract of the roots of Vernonia cinerea was investigated. Intraperitoneal administration of boiled milk at a dose 0.5 ml/kg body weight in albino rabbit leads to pyrexia. Intraperitoneal (i.p. route) administration of petroleum ether and chloroform soluble fractions of ethanol extract of the roots of Vernonia cinere...
PRELIMINARY PHYTOCHEMICAL ANALYSIS OF AEGLE MARMELOS, RUTA GRAVEOLENS, OPUNTIA DELLINI, EUPHORBIA ROYLEANA AND EUPHORBIA ANTIQUORUM
Plants are the local heritage with global importance. World is endowed with a rich wealth of medicinal plants. They represent and alternative treatment of non-serve cases of infections diseases. They are also the essential an integral part in complementary and alternative medicine and due to they which have developed the ability for the formation of various phytochemicals like terpenoids, steroids...
The aim of the study was to evaluate the circulating antioxidant such as vitamin C, vitamin E and GSH in nickel (Ni) induced toxicity in rats and in vitro free radical scavenging assay. In this investigation nickel sulfate (20 mg/kg body weight (b.w.) was administered intraperitoneally (i.p.) for 20 days to induce toxicity. Naringin was administered orally (80 mg/kg body weight) for 20 days with i...
STUDIES ON THE DISINTEGRANT PROPERTIES OF SEED POWDER, HUSK POWDER AND MUCILAGE OF PLANTAGO OVATA BY FORMULATION OF ORALLY DISINTEGRATING TABLET
Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Disintegrating tablets are intended to dissolve or disintegrate rapidly in the mouth for which various natural and synthetic disintegrants are included in the formulation. The present work emphasis on the study of disintegrant property of mucilage, Husk powder and seed powder of Isapghula...
HER2 stands for Human Epidermal growth factor Receptor 2. Each normal breast cell contains copies of the HER2 gene coding for HER2 protein found on the cell surface, which helps normal cells grow.HER2+ breast cancer is characterized by over expression of this gene in breast cells which fosters the cell growth giving rise to breast tumors. Studies show that 20-25% of breast cancer patients have...
Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complicationsincluding retinopathy, angiopathy, nephropathy, neuropathy and causing neurological disorders due to perturbation in utilization of glucose. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Putranjiva roxburghii Wall. has been ...
The aim of this study was to evaluate the anti-ulcerogenic activity of aqueous extract of Areca catechu L in ethanol induced ulcer model in Sprague Dawley Rats. For possible mechanism of anti-ulcerogenic potential, determination of ulcer index was done using the Merazzi-Uberti and Turba method. Also, analytical method was used to test the 10% homogenate preparation of mucosa of the glandular stoma...
The ethanolic extract of bark of Dalbergia sissoo Roxb. was investigated for its activity against Indian earthworms Pheretima posthuma and nematode Ascardi galli. Various concentrations (10, 20, 50 mg/ml) of ethanolic extract were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Piperazine citrate (15 mg/ml) and Albendazole (20 mg/ml) a...
VISUAL ESTIMATION AND SPECTROPHOTOMETRIC DETERMINATION OF TANNIN CONTENT AND ANTIOXIDANT ACTIVITY OF THREE COMMON VEGETABLE
Antioxidant activities of different vegetables Bitter gourd, Tomato and Spinach (Momordica charantia, Lycopersicon esculentum, Spinacia oleracea) were determined. In addition, rapid visual estimation of tannin content, total phenolic, tested for their free radical scavenging activity (FRSA) in the DPPH (1, 1-dephenyl- 2-picrylhydrazil radical) of those samples were assessed. A new technique was us...
SYNTHESIS, CHARACTERIZATION, BIOLOGICAL EVALUATION AND ADME STUDIES USING IN SILICO TECHNIQUES OF NOVEL DERIVATIVES OF BENZOTHIAZOLYL-AMIDES AS NON-ACIDIC ANTI-INFLAMMATORY AGENTS
Non-steroidal anti-inflammatory drugs (NSAIDs) have been used to treat various ailments for over 100 years. As a class, these drugs possess anti-inflammatory, anti-allergy, analgesic and antipyretic activity. A series of benzothiazolyl-amides has been synthesized and tested for anti-inflammatory activity. Basic NSAIDs are gaining interest because of their improved biological properties with the ai...