Pages Menu
TwitterRssFacebook
ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

A Web of Science - ESCI Indexed Journal
Projected Impact Factor (2019): 1.230 , CiteScore (2017): 0.27

Categories Menu

Volume 11 (2020) - Issue 4, April

Review Articles

 
Title
Views
PDF
Cited
1.

SUPERBUGS: THE POWERFUL WARRIORS

Antibiotics can no longer be considered as effective methods to treat various diseases. The misuse of these medicines has increased the evolvement of a number of drug-resistant microorganisms which are termed as “Superbugs”. These are most prevalent in developing countries where the abuse of antibiotics is at the peak. Clostridium difficile, Streptococcus pneumoniae, MRSA (Staphylococcus aureu...

S. Kaur, S. Hariharan and S. Dharmaraj *

Department of Biochemistry, Karpagam Academy of Higher Education, Eachanari Post, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1506-26

1506-1526

1070

774

2.

GUGGULSTERONE: MECHANISM OF ACTION AND PROSPECTS OF CHEMO PREVENTION IN PROSTATE CANCER

Remarkable pharmacological effects exhibited by Guggulsterone (GS) establish its potential as an effective anticancer agent. GS is widely known for its anti-inflammatory and hypolipidemic activities. At the molecular level, GS is known to modulate the activity of various nuclear receptors, growth factors and transcription factors. However, the complete sequence of the underlying anticancer mechani...

G. Jain and P. Das *

Centre for Genetic Disorders, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1527-36

1527-1536

804

357

3.

NANOEMULSION: A NOVEL TRAIT IN THE TREATMENT OF SKIN AGEING

Nanoemulsion system is a promising vehicle due to the powerful ability to deliver the drug through the skin. Researchers have been conducted to prove its potential for the delivery of the drugs used in many skin disorders. Skin is the largest organ and acts as the first line of defense of our body. After a certain period of time, our skin loses tone and elasticity which is called aging. It is the ...

N. S. Saraf, D. V. Gowda *, V. Jain and P. S. Babu

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1537-48

1537-1548

807

330

4.

ETHNOMEDICINAL USES AND PHARMACOLOGICAL ACTIVITIES OF DIFFERENT PARTS OF CUCUMIS SATIVUS LINN: AN UPDATE

Increasing demand of herbal medicines in the treatment of diseases has once again gained the immense importance due to its viable efficacy and compliance to the patients. Cucumis sativus L. is commonly known as cucumber and Khayarain in Unani medicine. It is found wildly in the Himalayan regions and also cultivated throughout India. Maghze tukhme khayarain (seeds of Cucumis) is in use in tradition...

R. Saeedi, A. Sultana * and K. Rahman

Department of Amraze Niswan wa Ilmul Qabalat (Gynecology and Obstetrics), National Institute of Unani Medicine, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1549-56

1549-1556

756

323

5.

NANOSPIDER TECHNOLOGY AND ITS APPLICATIONS

Electrospinning is a process wherein polymer fibers are developed on applying high voltage. Its principle is based on charge accumulation on the surface of the polymer solution as a result of high voltage which causes the solution to get ejected out as a thin jet by forming a taylor cone. Nanospider is a modified version of electrospinning developed by Technical University in the year 2003. The id...

D. Kala *, M. S. Athira and M. Mohan

College of Pharmaceutical Sciences, Government T. D. Medical College, Alappuzha, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1557-61

1557-1561

755

230

6.

FAST DISSOLVING TABLETS: A REVIEW

For treatment or management of diseases, oral delivery is giving much more attention from the ancient decade. A new concept in oral delivery is mouth dissolving tablets (MDTs) are widely accepted nowadays. Mouth dissolving tablets are solid dosage forms which, when placed in the mouth, disintegrate, dissolve and release active agent within a few minutes without the need for water. It has more sign...

R. Joshi *, N. Garud and W. Akram

Department of Pharmaceutics, School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1562-70

1562-1570

344

130

7.

AN UPDATE OVERVIEW OF RECENT ADVANCES ON FORMULATION DEVELOPMENT FOR COLON TARGETING

In targeted drug delivery systems, there is one of the most important drug delivery systems is colon targeting drug delivery system. This system is mainly used in the treatment of diseases like colonic cancer, ulcerative colitis, Crohn's disease. For local treatment of various bowel diseases colon is highly desirable. For the systemic action of nonpeptide drugs i.e., cardiovascular and antiasthmat...

B. Kumari, P. K. Upadhyay, M. Kumar *, S. Narwal, A. Pandurangan and A. Malik

M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1571-80

1571-1580

406

140

Research Articles

 
Title
Views
PDF
Cited
8.

ANTI-INFLAMMATORY EFFECT OF THE MOLECULAR PECTIN COMPLEX WITH ACETYLSALICYLLIC ACID ON A MODEL OF CARRAGEENAN PAW EDEMA IN RATS

The aim of this work is a comparison of anti-inflammatory properties of the molecular pectin complex with 10% acetylsalicylic acid (P-ASA) and acetylsalicylic acid (ASA) in equimolar doses on the model of carrageenan-induced paw edema of rats. The study was carried out on a total of 28 adult male Sprague Dawley rats at 7 months of age. 30 min after injection of 1% aqueous solution of carrageenan t...

A. B. Vyshtakalyuk *, K. N. Bushmeleva, O. A. Lenina, L. F. Gumarova, S. T. Minzanova, A. A. Parfenov, G. P. Belyaev, L. G. Mironova, E. V. Chekunkov and V. V. Zobov

Laboratory of Chemical-Biological Researches, A. E. Arbuzov Institute of Organic and Physical Chemistry - Subdivision of the Federal State Budgetary Institution of Science "Kazan Scientific Center of Russian Academy of Sciences", Kazan, Russia.

DOI: 10.13040/IJPSR.0975-8232.11(4).1581-91

1581-1591

744

371

9.

USING OF INFORMATIONAL PARAMETERS AS A CRITERION FOR DETERMINING THE EFFECTIVENESS OF BIOSTIMULATION WITH USE OF TISSUE PREPARATIONS

Possibility of use of the informational parameters, which characterize adaptational and regenerative opportunities of organ, as potential criteria for the assessment of biological activity of tissue preparations, is investigated in this research. The influence of tissue preparation «STEMB» on the morphofunctional condition of a liver of rats at experimental toxic damage of organs was studied. Th...

D. A. Areshidze *, M. A. Kozlova, L. A. Makartseva, A. A. Gritsyunayte, K. A. Sakhnova and E. A. Shmigelskiy

Researching Laboratory of Experimental Biology and Biotechnology, Moscow State Regional University, Moscow, Russian Federation.

DOI: 10.13040/IJPSR.0975-8232.11(4).1592-01

1592-1601

721

190

10.

SCREENING OF DIFFERENT ECO-TYPES OF MUNRONIA PINNATA (WALL) THEOB. FOR IMPORTANT PHYTOCHEMICAL PROPERTIES

Munronia pinnata is a rare medicinal plant, naturally distributed in China, India, Vietnam, Indonesia, Malaysia, Philippines, and Sri Lanka. The entire plant is extensively used for medicinal purposes, especially for curing skin diseases and treating fever, including malaria. Four major ecotypes were identified in Sri Lanka that consist of 3, 5, 7, and 9 leaflets from various regions. This study w...

P. E. Kaliyadasa *, M. K. Karunarathne, L. Jayasinghe and P. Marasinghe

Department of Export Agriculture, Uva Wellassa University, Badulla, Sri Lanka.

DOI: 10.13040/IJPSR.0975-8232.11(4).1602-09

1602-1609

688

250

11.

IN-VITRO ANTIOXIDANT AND IN-VIVO HEPATOPROTECTIVE ACTIVITY OF GANODERMA LUCIDIUM STRAINS DARL-4 & MS-1 AGAINST PARACETAMOL INDUCED HEPATOTOXICITY

The purpose of current research work is to evaluate the in-vitro antioxidant and in-vivo hepatoprotective activity of Ganoderma lucidum strains DARL-4 and MS-1. Antioxidant activity of different extracts was evaluated by using DPPH and ABTS method. Hepatoprotective activity of hydroalcoholic extract of G. lucidum strain DARL-4 and MS-1 were evaluated by paracetamol-induced liver damage in rats. Th...

Swati *, A. Singh and H. Meena

Defence Institute of Bio-Energy Research, DRDO, Haldwani, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1610-16

1610-1616

660

247

12.

OPTIMIZATION, EVALUATION AND STABILITY STUDY OF NUTRACEUTICAL POWDER FORMULATIONS DEVELOPED FROM EDIBLE SEED AND LEAFY- VEGETABLE SOURCES

Nutraceutical term is a combination of terms nutrient and pharmaceutical. There is a wide scope in applying pharmaceutical formulation parameters to nutraceuticals. Amongst the variety of nutraceuticals available, powder form of nutraceuticals are most popular. The nutraceutical powder mixtures can contain many ingredients, of which the nutrient source contents are generally present in more than 5...

M. C. Singh *, K. N. Gujar and I. Singhvi

S.T.E.S’s Smt. Kashibai Navale College of Pharmacy, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1617-28

1617-1628

689

256

13.

EFFICACY AND SAFETY OF VILDAGLIPTIN AND TENELIGLIPTIN IN PATIENTS OF TYPE 2 DIABETS MELLITUS INADEQUATELY CONTROLLED ON STABLE DOSES OF METFORMIN

This was a 24-week, randomized, open label study. Treatment-naive patients diagnosed with Type 2 diabetes mellitus were randomized into two groups, Group-1 (Vildagliptin 50 mg, twice dailyplus Metformin 500 mg, twice daily) and Group-2 (Teneligliptin 20 mg, once dailyplus Metformin 500 mg, twice daily). The primary objective was to compare fasting plasma blood glucose levels (FBG), 2-h post prandi...

N. Rizvi, J. Ahmad *, F. Ahmad and S. S. Siddiqui

Department of Pharmacology, J. N. Medical College, AMU Aligarh, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1629-34

1629-1634

774

133

14.

MOLECULAR DOCKING AND ADMET STUDIES OF BIOACTIVE COMPOUNDS OF RHIZOPORA MUCORNATA AGAINST BACTERIAL ENZYME PROTEIN TYROSINE PHOSPHATASE

Objective: The bioactive compounds of Rhizopora mucornata were docked against the bacterial enzyme protein tyrosine phosphatase to determine the potential inhibition. In this research the molecular docking analysis of drug compounds with virulent protein was studied. Material and Methods: Protein Tyrosine phosphatase is an enzyme that is being present in staphylococcus infection that plays an impo...

R. A. Biswal, A. Sharma, A. Aishwariya and V. Pazhamalai *

Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1635-42

1635-1642

313

127

15.

MICROWAVE INDUCED SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG SIMVASTATIN USING POLOXAMER 188 BY MICROWAVE IRRADIATION METHOD

To increase the solubility of poorly water-soluble drug simvastatin using hydrophilic carrier poloxamer 188 using solid dispersion techniques by microwave irradiation method. The microwave irradiation technique was used to prepare solid dispersions in minimum time interval in different drug carrier ratios, i.e. 1:2, 1:5, 1:8 and was subjected to microwave for different times, i.e. 3 min, 5 min, an...

A. Raina * and D. Kaur

P. S. College of Pharmacy and Paramedical Sciences, Jammu, Jammu and Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1643-52

1643-1652

282

103

16.

A NEW VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF GRAZOPREVIR AND ELBASVIR IN TABLET DOSAGE FORMS

A combination of Grazoprevir and Elbasvir is used to treat Hepatitis C virus (HCV). A selective, accurate and precise RP-HPLC method was developed and validated for the simultaneous estimation of these drugs in combined tablet dosage forms. The drugs were resolved on a BDS C18 column using 0.1% orthophosphoric acid: Acetonitrile (45:55 v/v) as the mobile phase. The detection wavelength was 260 nm....

D. V. Kumar * and J. V. L. N. S. Rao

School of Pharmaceutical Sciences & Technologies, Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1653-59

1653-1659

335

126

17.

UPLC STABILITY INDICATING METHOD FOR SIMULTANEOUS ESTIMATION OF GLECAPREVIR AND PIBRENTASVIR

A forced stability-indicating method for simultaneous estimation of glecaprevir and pibrentasvir by Ultra Performance Liquid Chromatography (UPLC) was developed and validated. The separation was done on column BEH C18 50 × 2.1mm 1.7m which was maintained at 30 °C, eluted with isocratic mobile phase and eluents were detected at 260nm. Mobile phase containing Buffer 0.01NKH2PO4: Acetonitrile taken...

K. P. Kumari * and D. G. Sankar

Department of Pharmaceutical Analysis, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1660-65

1660-1665

288

98

18.

UV-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF LORNOXICAM AND EPERISONE HYDROCHLORIDE IN BULK DRUG, FORMULATIONS AND AQUEOUS DISSOLUTION SAMPLES

Lornoxicam has been found to be not interacted by eperisone hydrochloride at 377 nm. Therefore, it is estimated directly as a single component in the mixture, whereas eperisone hydrochloride is throughout interfered with by lornoxicam in UV region. So, it was estimated in the mixture using a two-wavelength difference method. Lornoxicam was found to have same absorbance at 262 nm and 283 nm but not...

N. Prasad *, P. Singh and P. Kumar

SGT College of Pharmacy, SGT University, Gurugram-Badli Road, Budhera, Gurugram, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1666-73

1666-1673

271

95

19.

DEVELOPMENT OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF AMOXICILLIN AND CARBOCISTEINE IN SOLID DOSAGE FORM BY RP-HPLC

Pharmaceutical analysis is the application of principles of analytical chemistry to drug analysis. The analytical chemistry is the science of developing accurate, precise, and sensitive methods for determining the composition of materials in terms of elements or compounds which they contain. Quality means confirming specifications and standards, and it is never an accident; it is a result of intel...

S. S. Mankar * and M. Younas

Department of Quality Assurance, Agnihotri College of Pharmacy, Wardha, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1674-82

1674-1682

271

99

20.

IDENTIFICATION, QUANTITATIVE DETERMINATION AND ANTIDEPRESSANT ACTIVITY OF CHLOROGENIC ACID AND GALLIC ACID FROM MORUS ALBA LEAVES

Objective: The present study is considered to estimate preliminary phytochemical components, physicochemical parameters, HPTLC chromatographic studies and antidepressant activity of chlorogenic acid & gallic acid present in extracts of Morus alba leaves. Methods: Total phenol content, total flavonoid content, total tannin content, HPTLC fingerprinting analysis for compounds like chlorogenic ac...

S. B. Singh * and A. Singh

Hygia Institute of Pharmaceutical Education and Research, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1683-89

1683-1689

266

94

21.

THE RELATIONSHIP BETWEEN CLINICAL FEATURES AND MAGNETIC RESONANCE IMAGING PROVED LUMBAR DISC BULGING AND HERNIATION

Background: Lumbar disc herniation is one of the commonest causes of low back pain. The magnetic resonance imaging is a gold standard non-invasive investigation for viewing lumbar anatomy in detail. Aim of the Study: To evaluate the effects of body mass index on the presence, extent and severity of lumbar disc bulging and herniation as well as to determine the relationship between clinical feature...

K. AL-Bedri, I. N. Ali, Z. A. Mahmood * and I. S. Swadi

F.I.B.M.S (Rheumatology and Rehabilitation) lecturer of Medicine, Department of Medicine, College of Medicine, University of Basra, Basra, Iraq.

DOI: 10.13040/IJPSR.0975-8232.11(4).1690-97

1690-1697

241

93

22.

A HPTLC DENSITOMETRIC METHOD FOR THE DETERMINATION OF β -SITOSTEROL IN PERGULERIA DAEMIA LEAF AND STEM EXTRACT

HPTLC is a simple, rapid, precise and accurate method with densitometric detection for the determination of beta-sitosterol in a Pergularia daemia Forsk. Petroleum ether and methanol extract of the leaf and stem were powder and used for the experimental work. The separation was performed on silica gel 60 F254 HPTLC plates with Toluene: Ethyl acetate (80:20 v/v), as the mobile phase. The determinat...

N. G. Sutar * and P. P. Patil

Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Ahmednagar, Maharashtra India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1698-04

1698-1704

428

109

23.

DETECTION OF HUMAN PARVOVIRUS B19 AMONG PATIENTS WITH FEVER-RASH LIKE ILLNESS IN NORTH INDIAN POPULATION

Introduction: The present study designed to investigate Human parvovirus B19 (HPV-B19) as an etiological agent of rash–fever ill patients confirmed negative for measles and rubella infection which is responsible for the same symptoms in North Indian population. Materials and Methods: Total 319, negative serum samples selected after measles/rubella IgM antibodies detection. The patients between t...

A. Pandey, R. Tripathi, N. Tejan, R. Chaturvedi * and T. N. Dhole

Amity Institute of Biotechnology, Amity University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1705-10

1705-1710

244

77

24.

ANTICARIOGENIC ACTIVITY OF GALLS OF QUERCUS INFECTORIA OLIVIER AGAINST ORAL PATHOGENS CAUSING DENTAL CARIES

In this study, attempts were made to evaluate the anti-microbial activity of the galls of Quercus infectoria Olivier against oral bacteria causing dental caries. Various solvents systems were used to screen the potential of the extract on the clinically isolated organism and reference strains; Candida albicans MTCC 183, Streptococcus mutans MTCC 497, Lactobacillus acidophilus MTCC 10307 and Staphy...

M. R. Dsouza *, B. S. Aishwarya and S. S. Supriya

Department of Biochemistry, Mount Carmel College Autonomous, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1711-18

1711-1718

245

83

25.

BIOCHEMICAL CHARACTERIZATION OF FREE AND IMMOBILIZED α–AMYLASE FROM ASPERGILLUS NIGER AND ITS BIOTECHNOLOGICAL APPLICATIONS

α-amylase is widely used in various biotechnological applications such as food processing, starch, and paper industries, hydrolyzing starch, glycogen, and other polysaccharides into glucose, maltose, and oligosaccharides. Aspergillus niger α-amylase was partially purified by ammonium sulphate fractionation with 1.409 fold purity and 54.88% yield. The partially purified α-amylase was immobilize...

N. Kote *, A. C. Manjula, T. Vishwanatha and E. Keshamma

Department of Biochemistry, Maharani’s Science College for Women, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1719-26

1719-1726

438

86

26.

ANTI-DIARRHEAL AND ANTI-OXIDANT ASSESSMENT OF MIMUSOPS ELENGI LINN. UNRIPEN FRUIT EXTRACTS

The objective of the research was to investigate and evaluate anti diarrheal, antioxidant activity Mimusops elengi Linn. unripen fruit extracts. Mimusops elengi Linn. unripen fruits is considered as one of the best medicinal plants due to its several pharmacological uses mentioned in Unani as well as ethnomedicine. The various extracts of the plant (bark, fruit, leaves, seed, and flowers) have bee...

S. Dash *, A. C. Sahoo, B. Mishra, A. K. Senapati and P. K. Sahu

Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1727-34

1727-1734

238

99

27.

FORMULATION, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY EVALUATION OF COLLAGEN BASED SILVER NANOPARTICLE

Nanoparticles are widely used in different technological fields, one of which is medicine. Collagen is used in several types of wound dressing. A silver nanoparticle is used as an antimicrobial agent to reduce microbial infection. In this research work, we have synthesized silver nanoparticles with collagen and studied for antibacterial activity against aureus (S. aureus), Escherichia coli (E. col...

D. L. Aswana, R. B. Roselin and V. Sankar *

Department of Pharmaceutics, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1735-39

1735-1739

282

100

28.

FABRICATION AND CHARACTERIZATION OF CICLOPIROX OLAMINE LOADED NONIONIC SURFACTANT BASED NIOSOMES FOR TOPICAL DELIVERY

A number of strategies to deliver antifungal using nanocarriers are developed to facilitate drug targeting infected cells that result in improved antifungal activity. Objective: Ciclopirox olamine has a broad spectrum of action against dermatophytes, yeasts, filamentous fungi and bacteria. It has a biological half-life of 1.7 h and bioavailability of < 5% with prolonged use. A remarkable featur...

G. G. Keshavshetti * and S. B. Shirsand

Department of Pharmaceutics, SVET’s College of Pharmacy, Humnabad, Bidar, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1740-48

1740-1748

266

99

29.

DEVELOPMENT AND VALIDATION OF UV-SPECTROSCOPIC METHOD FOR THE ESTIMATION OF LYMECYCLINE IN CAPSULE DOSAGE FORM

Lymecycline is a tetracycline broad-spectrum antibiotic. Present work describes a simple, accurate, precise, economical and reproducible spectrophotometric method in ultraviolet region has been developed and validated for the assay of Lymecycline in bulk and in Pharmaceutical formulations in diluent. Lymecycline is a tetracycline broad-spectrum antibiotic. Lymecycline like other tetracyclines is u...

U. Narasimhulu *, M. Madhu, C. Sireesha, V. Vyshnavi and S. Rafi

Department of Pharmaceutical Analysis and Quality Assurance, Annamacharya College of Pharmacy, New Boyanapalli, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1749-56

1749-1756

267

84

30.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING ASSAY FOR SIMULTANEOUS DETERMINATION OF PENTAPRAZOLE, DICLOFENAC, CHLOROXAZONE IN PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC

Objective: A simple, accurate, precise method was developed for the simultaneous estimation of the Chlorzoxazone, Pantoprazole, and Diclofenac in solid dosage form. Method: Chromatogram was run through BDS C18 150 × 4.6 mm, 5 m. Mobile phase containing 0.01% KH2PO4 and Acetonitrile in the ratio of 52:48 v/v was pumped through column at a flow rate of 1.0 ml/min. The buffer used in this method was...

P. Sakinala *, H. Vahika, K. Santhosh and S. Attinti

Department of Pharmaceutical Analysis, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1757-67

1757-1767

294

95

31.

ISOLATION, CHARACTERIZATION, PRODUCTION AND PURIFICATION OF FIBRINOLYTIC ENZYME NATTOKINASE FROM BACILLUS SUBTILIS

The objective of the present study was characterization, production, and purification of Nattokinase from Bacillus subtilis. A fibrinolytic enzyme-producing bacterium was isolated and identified as Bacillus subtilis from fermented soybean and soil. Bacillus subtilis showed a very strong protease activity by degrading casein skimmed milk agar. Nattokinase was produced on basal medium and then purif...

D. Sharma *, S. K. Shekhar, A. Kumar and J. Godheja

Department of Biochemistry, King George’s Medical University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1768-76

1768-1776

353

106

32.

HISTOPATHOLOGICAL ALTERATIONS IN ALLOXAN INDUCED DIABETIC MICE LIVER AND KIDNEY AFTER CARISSA SPINARUM METHANOLIC LEAF EXTRACT TREATMENT

Carissa spinarum is an evergreen, thorny shrub found in the Himalayan areas of the Indo-Pakistan subcontinent. The plant has a number of ethnomedicinal applications. Pharmacologically this plant is used for the treatment of asthma and pulmonary diseases, anticancer, diarrhea, hepatoprotective, cardioprotective and reproductive dysfunction. The present study is aimed to study effects of Carissa spi...

S. Sharma and A. Rana *

Department of Biosciences, Himachal Pradesh University, Summer Hill, Shimla, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1777-83

1777-1783

214

84

33.

FUNGAL INFECTION CAUSES HISTOPATHOLOGICAL ALTERATIONS IN GILL AND PANCREAS OF CHANNA STRIATUS

Histomorphological changes were observed to assess the effect of fungus on gill and pancreas of Channa striatus. The most frequent histological changes detected in the gills included hypertrophy, hyperplasia and fusion of secondary lamellae. Other lesions found were vacuolization and blood congestion in Pancreas. The colonization of aquatic fungi in teleost fish is a severe problem affecting both ...

P. K. Rao

Department of Zoology, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1784-89

1784-1789

234

80

34.

BIOACTIVITY AND TAXONOMIC STUDIES OF NOCARDIOPSIS DASSONVILLEI AND NOCARDIOPSIS SPECIES FROM MARINE SEDIMENTS OF BAY OF BENGAL, INDIA

Globally, the outbreak of antibiotic-resistant pathogens derived infections urged an intensifying necessity for the survey of underexplored marine zone microorganisms for novel metabolites. Our current study emphasized on isolation, polyphasic characterization and bioactivity of the novel actinomycetes from the Bay of Bengal near Kakinada and Nizampatnam, Andhra Pradesh, India, which could provide...

R. Ragireddypallem, V. Muvva *, K. Mallikarjuna and V. K. Ikkurthi

Department of Botany and Microbiology, Acharya Nagarjuna University Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1790-01

1790-1801

240

89

35.

EVALUATION OF MELATONIN AND COENZYME Q10 FOR GASTROPROTECTIVE EFFECT IN ASPIRIN AND IBUPROFEN INDUCED GASTRIC ULCERS IN RATS

The present study was carried out to evaluate the gastroprotective effect of melatonin, coenzyme Q10 (CoQ10) and its combinations with rabeprazole in aspirin (400 mg/kg) and ibuprofen (300 mg/kg) induced gastric ulcers in albino Wistar rats. In aspirin-induced gastric ulcer model, the treatment of melatonin (20 mg/kg), CoQ10 (100 mg/kg) and rabeprazole (20 mg/kg) for 10 days significantly reduced ...

P. Kulkarni, G. Bhavimani, A. Javalgikar and N. Mahurkar *

Department of Pharmacology, HKES MTRIPS, Kalaburagi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1802-07

1802-1807

267

96

36.

DESIGN AND CHARACTERIZATION OF SILVER NANOPARTICLES OF MOMORDICA CHARANTIA LINN. BY GREEN SYNTHESIS

Objective: Present research work describes an eco-friendly and quick method for the development of silver nanoparticles (AgNP) using Momordica charantia Linn. extract and silver nitrate solution. Our investigation reports the antimicrobial activity of developed nanoparticles against Staphylococcus aureus, Escherichia coli. Method: Silver nanoparticle developed by reduction of silver nitrate soluti...

S. T. Galatage and D. S. Parpolkar *

Quality Assurance, Zydus Cadila, Kundaim Industrial Estate Ponda, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1808-15

1808-1815

268

102

37.

EVALUATION OF FIELD AND LABORATORY RESPONSES OF MALE XANTHOPIMPLA PREDATOR TO SYNTHETIC PHEROMONE LURES

Mating disruption by an artificial release of synthetic female pheromone components like Tetradecyl acetate (A), Ethyl (Z)-9-hexadecenoate (B) and a mixture of these two at different concentrations is a feasible method to control Xanthopimpla predator. Male Xanthopimpla predator was evaluated for responses to these synthetic pheromone components in a laboratory wind tunnel and in Terminalia arjuna...

L. Marepally

Post - Doctoral Fellow (UGC), Department of Zoology, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1816-22

1816-1822

239

87

38.

ANALYTICAL METHOD DEVELOPMENT & VALIDATION FOR RELATED SUBSTANCES IN DIPYRIDAMOLE BY RP-HPLC

Simple RS method is developed and validated as reversed-phase chromatographic method for the identification and quantification of the dipyridamole related substances-A, B, C, D, E and F. Chromatographic separation has been achieved by using Shodex C18, 150 mm, 4.6 mm diameter, 5 µ column, using mobile phase 0.1 % of formic acid and acetonitrile by eluting in gradient with 1.0 ml flow, detection w...

T. Menaka and B. R. Kuber *

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupathi, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1823-30

1823-1830

231

81

39.

EVALUATION OF MYCOPLASMA HOMINIS PROTEOME TO IDENTIFY THE POTENTIAL VACCINE CANDIDATE PROTEINS

Objective: Mycoplasma hominisis a gram-negative bacteria belonging to class Mollicutes that is commonly present in men and women of reproductive age. At present, there is no effective prophylaxis for Mycoplasma hominis, as it has gained resistance for the drugs hence an in-silico approach was undertaken to find out the peptide-based vaccine for the pathogen. Methods: In women, it affects the genit...

S. Madagi and S. Shiragannavar *

Department of Studies and Research in Bioinformatics, Karnataka State Akkamahadevi Women’s University Vijayapura, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1831-36

1831-1836

240

83

40.

METHOD DEVELOPMENT AND VALIDATION OF LC-ESI-MS/MS TECHNIQUE FOR THE ESTIMATION OF MODAFINIL IN HUMAN PLASMA; APPLICATION TO PHARMACOKINETICS IN HEALTHY RABBITS

A new simple and sensitive liquid chromatography-electrospray ionization-tandem-mass spectrometric (LC-ESI-MS/MS) technique was developed and validated for the estimation of modafinil in human plasma and the method was applied to study pharmacokinetics in healthy rabbits. Chromatography was attained on Phenomenex- C18 (50mm × 4mm) 5µ column and acetonitrile, methanol and 0.1% formic acid (25:60:...

A. Phanindra * and Y. S. Kumar

Mewar University, Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1837-44

1837-1844

232

84

41.

COMBINED ANTICONVULSANT EFFECT OF NIFEDIPINE AND PENTAZOCINE IN EXPERIMENTALLY INDUCED CONVULSIONS BY ELECTRO CONVULSOMETER IN MICE AND RATS

The present study aimed to investigate the combined anticonvulsant effect of nifedipine (calcium channel blocker) and pentazocine (opioid analgesic) on the duration of convulsions, tonic hind limb extension and recovery in mice and rats. The study was initiated after obtaining ethical approval from the Institutional Animal Ethics Committee (IAEC), Department of Pharmacology, Osmania Medical Colleg...

S. B. Kumar *, A. Rajanna and N. Balakrishna

Drug Toxicology Division ICMR-National Institute of Nutrition Ministry of Health & Welfare, Jamai-Osmania, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1845-49

1845-1849

223

70

42.

PHYTOCHEMICAL ANALYSIS AND IN-VITRO ANTI-OXIDANT ACTIVITY OF HYDROALCOHOLIC EXTRACT FROM TENDER COCONUT MESOCARP

Free radicals are responsible for the development of many diseases. Anti-oxidants play an important role in scavenging free radicals. Anti-oxidant activity of herbal extracts and isolated compounds are reported earlier. Pharmaceutical industries are carrying out research in the development of new potent antioxidants. Novel drug development from economically cheapest plant waste might be useful for...

R. Elanthendral, S. Bhuvaneswari and K. Gayathri *

Department of Biochemistry, VISTAS, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1850-58

1850-1858

232

84

43.

STUDY OF VARIATION IN ELECTROCHEMICAL BEHAVIOUR OF FURAZOLIDONE AND METRONIDAZOLE SIMULTANEOUSLY BY DIFFERENTIAL PULSE VOLTAMMETRY

In present study, a successful attempt has been made to study the variation in electrochemical behavior of Furazolidone and Metronidazole simultaneously using Differential Pulse Voltammetry (DPV) technique. The effect of different pH (2-10) of Britton-Robinson Buffer on voltammogram using 1M KCl as a supporting electrolyte was studied. The optimum pH was found to be pH 4.25. Both Furazolidone and ...

V. Wagh

Department of Chemistry, Ramnarain Ruia Autonomous College, Matunga (East), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1859-62

1859-1862

233

84

44.

ENVIRONMENTAL WELLNESS WITH SPECIAL REFERENCE TO HAEMATOZOAN INFECTION IN REPTILIAN HOSTS

Environment provides a solid platform for good health. An unhealthy environment makes place unsafe for wild animals. One of the effects is a parasitic load on these animals, as a high degree of parasitization may cause harm to the health of these animals. In the present research work, blood parasitic infestation in two species of lizards, Hemidactylus flaviviridis and Calotes versicolor were inves...

M. Bhaskar * and N. Gupta

Department of Zoology, D. B. S. College, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1863-67

1863-1867

212

84

45.

A STUDY ON EFFECT OF THERMAL SINTERING ON GASTRIC FLOATING TABLETS

The purpose of this study was to develop a gastroretentive controlled release drug delivery system using sintering for enhanced oral bioavailability using carnauba wax polymer. Formulations (CC1-CC3) were prepared by wet granulation method and then exposed to sintering temperature at different time intervals. The optimized formula showed zero-order drug release kinetics for the period of 12 h. The...

M. G. Ramya * and K. B. C. Sekhar

Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1868-73

1868-1873

239

82

46.

EVALUATION OF ANTIGENOTOXIC POTENTIAL OF BEET ROOT EXTRACT AGAINST HAIR DYE INDUCED GENOTOXICITY

In-vitro investigations toward DNA damage reported that the biological effect of genotoxic exposures could influence the life cycles of different human cells. Sister chromatid exchange (SCE) assay is broadly used, sensitive cytogenetic biomarker of exposure to genotoxic agents. Naturally available products may play a significant role against the cytogenetic damage but available research data is no...

S. Kumar, V. Vishwakarma, B. Yadav, R. Gupta, N. K. Aggarwal and A. Yadav *

Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1874-78

1874-1878

286

86

47.

DESIGN AND EVALUATION OF CIPROFLOXACIN FLOATING TABLETS USING THERMAL SINTERING TECHNIQUE

The main of this study was production of floating tablets to maintain the drug stay in its absorption area. Ciprofloxacin is better absorbed in the stomach because of this reason floating matrix tablet was prepared using novel sintering technique with sodium bicarbonate as gas generating agent and a polymer eudragit robust formulation was decided on the basis of floating time and in-vitro drug rel...

R. Akki *, S. A. Parameswari and K. B. C. Sekhar

Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1879-84

1879-1884

245

88

48.

THE IN-VITRO ANTI-DENATURATION EFFECTS INDUCED BY SUBSTITUTED OXY/THIOXY PYRIMIDINE DERIVATIVES IN BOVINE SERUM ALBUMIN IS PROPOSED AS A SCREENING ASSAY FOR THE DETECTION OF ANTI-INFLAMMATORY COMPOUNDS WITHOUT THE USE OF ANIMALS

A series of novel 2-{[6-(2-substituted Phenyl)-2-oxo-1, 2-dihydropyrimidin -4-yl]oxy} benzoic acid (2a-b)/ 2-{[6-(2-substituted Phenyl)-2 thioxo-1, 2-dihydropyrimidin-4-yl]oxy} benzoic acid (2c-d) were synthesized and tested for their in-vitro protein denaturation activity. Compound 2d was found to be promising and was more potent than the Acetylsalicylic acid (NSAID) in the inhibition of Bovine s...

M. Banerjee * and S. K. Sahu

Institute of Pharmacy & Technology, Salipur, Cuttack, Orissa, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1885-88

1885-1888

240

78

49.

AQUEOUS EXTRACTS OF VERNONIA AMYGDALINA AND OCIMUM GRATISSIMUM PROTECT AGAINST ELECTROLYTE DERANGEMENT IN SALT-LOADED RATS

The study aimed at checking the effects of aqueous extracts of Vernonia amygdalina and Ocimum gratissimum on the electrolyte level of salt-loaded rats. 25 male rats weighing 160-220g were shared into 5 groups of 5 rats. Group 1 animals that were fed standard feed and water served as the control. Animals in group 2-5 which were salt-loaded orally with 2 ml of 4% sodium chloride solution for 2 weeks...

U. V. Igbokwe, E. D. Eze *, M. D. Adams and C. F. Chukwuegbo

Department of Physiology, Faculty of Biomedical Sciences, Kampala International University, Ishaka, Bushenyi, Uganda.

DOI: 10.13040/IJPSR.0975-8232.11(4).1889-97

1889-1897

266

87

50.

DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDIES ON NOVEL CINNOLINE DERIVATIVES AS POTENTIAL ANTITUBERCULOSIS AGENTS

The emerging need for the multidrug regimen of M. tuberculosis strains urged us to synthesize novice and potent anti-tubercular medicaments. Our interest in this work had afforded a series of novice cinnolines as a new structural category of antituberculosis agents. All 14 compounds were synthesized using the appropriate scheme, two-step reactions with the high yielding product. The newly synthesi...

M. P. Evangelin *, P. P. Kumar and K. Balamurugan

Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1898-05

1898-1905

264

108

51.

FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE FILMS OF ZOLMITRIPTAN

Formulation development for new drugs, an extension of formulations, finding an alternative to conventional dosage forms for better therapeutic response are some of the research impetus in Pharmaceutical F and D. The new -untried routes of administration are also an avenue that can be explored. Under this research zolmitriptan, an antimigraine, BCS class II drug is formulated into mucoadhesive fil...

M. C. Singh * and G. K. Andhale

S.T.E.S.’s Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1906-16

1906-1916

236

88

52.

TOPICAL TREATMENT USING ANTIHISTAMINIC, STEROID AND A COMBINATION OF BOTH IN ALLERGIC RHINITIS-A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL

This study evaluates the effectiveness of corticosteroid fluticasone propionate, antihistaminic azelastine, and a combination of both as well as to find out the prognostic significance of absolute eosinophil count (AEC) in the topical treatment of allergic rhinitis. All cases presenting with symptoms of nasal allergy were included maintaining double-blind status. A total of 225 participants of gro...

A. D. Havle *, N. Pincha and S. C. Prabhune

Department of Otorhinolaryngology, Krishna Institute of Medical Sciences Deemed to be University, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1917-21

1917-1921

241

82

53.

ESTIMATION OF HMG-COA REDUCTASE INHIBITOR HAS CHRONOPHARMACEUTICAL DELIVERY SYSTEM VIA NOVEL COATING METHOD

Introduction: The aim of the present study is to formulate and evaluate the simvastatin chronopharmaceutical delivery system using a novel coating method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 6 h. Observation: Simvastatin is a hyperlipidemia drug that inhibit the synthesis of cholesterol by inhibiting the HMG-COA reductase enzy...

V. Sandhiya

Department of Pharmaceutics, C. L. Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1922-33

1922-1933

217

74

54.

MOLECULAR DOCKING AND TOXICITY STUDIES OF SERIES OF COMPOUNDS FROM DIARYL UREA HITS & SPIRO PIPERIDINE INDOLINYL SERIES AS POTENTIAL P2Y1 RECEPTOR ANTAGONISTS

Scientific investigations revealed that the study of P2Y1 receptors is very much essential in the current scenario because of their potential role in related to various disorders/diseases like thrombosis, cardiovascular problems. P2Y1 receptors belong to G protein-coupled receptors, an important target for ADP induced platelet aggregation. Blockade of P2Y1 receptors leads to the treatment of throm...

N. V. L. S. Mulukuri *, B. M. Dinesh, D. K. Jha and T. Prabhakar

Department of Pharmaceutical Chemistry, Nitte College of Pharmaceutical Sciences, Govindapura, Gollahalli, NMIT Campus Yelahanka, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1934-40

1934-1940

225

68

55.

USAGE ASSESSMENT OF COMPLEMENTARY AND ALTERNATIVE MEDICINE IN SAUDI DIABETIC PATIENTS

Complementary and alternative medicines (CAMs), particularly herbal medicines (HMs), are popular with diabetic patients and are often used alongside conventional treatments. In such cases, patients usually do not advise their doctor or any other healthcare professional, so inappropriate use and potential interactions between CAM therapies and conventional treatments are serious concerns. This stud...

S. M. Alsanad

Department of Pharmacology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(4).1941-48

1941-1948

251

78

56.

THERAPEUTIC EFFECT OF MORINGA OLEIFERA LEAF EXTRACTS ON OXIDATIVE STRESS AND KEY METABOLIC ENZYMES RELATED TO OBESITY

Obesity ailments, commonly known as “New World Syndrome,” has drawn the attention of the scientific community to explore novel natural product-based therapeutics as effective alternatives. In this study, different solvent extracts of Moringa oleifera (M. oleifera; Drumstick tree) leaves were prepared, and their phytochemical analysis was done. The therapeutic effect of M. oleifera leaf extra...

G. M. Swamy and B. Meriga *

Department of Biochemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1949-57

1949-1957

205

80