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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

A Web of Science - ESCI Indexed Journal
Projected Impact Factor (2019): 1.230 , CiteScore (2017): 0.27

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Volume 11 (2020) - Issue 7, July

Review Articles

 
Title
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1.

ZINGIBER OFFICINALE EFFECT ON HELICOBACTER PYLORI INFECTION IN HUMAN; A SYSTEMATIC REVIEW

Helicobacter pylori (HP) as a non-invasive microbe, has been cloned in the stomach. The most important side effects of HP are inflammation, peptic ulcer (PU) and gastric cancer (GC). Control of inflammation, leads to preventing other HP side effects and antibiotic resistance, therefore it is important to use of natural anti-inflammatory compounds. In present study, review the effect of Zingiber of...

V. Mirzaee, A. Jafarzadeh, A. Tahmasebi and S. Jalalpour *

Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

DOI: 10.13040/IJPSR.0975-8232.11(7).3047-59

3047-3059

46

45

2.

ADVANCEMENTS IN SKIN DELIVERY: A TRANSDERMAL SCIENCE

Transdermal drug delivery system (TDDS) provides an alternate safe way of drug delivery compared to other invasive techniques. Documented advancement in transdermal science provides sustainable delivery of drug molecules, improved bioavailability, the better therapeutic efficacy of embedded drug’s and ability to deliver the drug at a constant rate and also reduces the adverse effects associated ...

K. Rajesh *, N. Upamanyu and V. Jain

School of Pharmacy and Research, Peoples University, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3060-68

3060-3068

43

24

3.

CONTRIBUTIONS OF WILD MUSHROOMS IN LIVELIHOOD MANAGEMENT OF ETHNIC TRIBES IN GURGURIPAL, WEST BENGAL, INDIA

The folk population of Gurguripal has mycophilic inclination, and wild mushrooms play a significant role in sustaining their livelihood. Explorative survey work was undertaken to document the ethnomycological knowledge of wild mushrooms occurring in forest areas of Gurguripal. In the present study, 166 informants from 9 villages were interviewed and information was collected through semi-structure...

K. Singha, S. Sahoo, A. Roy, A. Banerjee, K. C. Mondal, B. R. Pati and P. K. D. Mohapatra *

Department of Microbiology, Raiganj University, Raiganj, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3069-80

3069-3080

45

29

4.

POLLUTION IN DENTISTRY A CRITICAL REVIEW

Health may be defined as the capability to adapt and manage physical, mental, and social concerns throughout life. Oral health is a key indicator of overall health, wellbeing, and quality of life. WHO defines oral health as “a state of being free from chronic mouth and facial pain, oral and throat cancer, oral infection and sores, periodontal (gum) disease, tooth decay, tooth loss and other dise...

J. Kavitha *, S. Sivakrishnan, S. L. Sree and S. Srinivasan

Department of Periodontia, RMDCH Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3081-89

3081-3089

39

25

5.

A BRIEF REVIEW ON GLYCOMIMETICS AND THEIR PHARMACEUTICAL APPLICATIONS

This review enumerates the classification, role, and importance of carbohydrate derivatives and glycomimetics. Carbohy-drates are polyhydroxy aldehydes or ketones. Carbohydrates are the most abundant dietary source of energy for all organisms. They are precursors for many organic compounds such as fatty acids and amino acids. They can participate in the structure of cell membranes and cellular fun...

P. Naresh *, S. Jubie, T. Prabha, P. Shyam Sundar and S. B. Santhosh

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund, the Nilgiris, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3090-98

3090-3098

35

19

6.

NANOSPONGES – NOVEL EMERGING DRUG DELIVERY SYSTEM

The contemporary development in the drug delivery system is a seamless process. Any delivery system targeting a molecule to a particular site is always been appreciated. This requirement can be fulfilled through a specialized drug delivery system that can easily target the drug at the site of action without compromising its efficacy and quality. Few new drugs typically cannot be effectually delive...

T. K. Satpathy *, N. Chaubey, B. U. Sri and V. R. Naidu

College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3099-12

3099-3112

26

18

7.

MICROPHARMACEUTICAL’S – A REVIEW ON MICROSPHERRICAL APPLICATIONS AND RECENT ADVANCES

Microspheres are small spherical free-flowing particles, with diameters 1 μm to 1000 μm consisting of proteins or synthetic polymers which are biodegradable in nature. They are prepared to obtain prolonged or controlled drug delivery to improve, bioavailability, stability and to target the drug to a specific site at a predetermined rate. Microspheres are of various types and are prepared by diff...

H. Rastogi *, A. K. Pandey and H. D. Purkyustha

Department of Pharmaceutics, RAM-EESH Institute of Vocational and Technical Education, Institute of Pharmacy, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3113-20

3113-3120

29

13

8.

CANCER CAUSES AND TREATMENTS

Cancer is a genetic disorder that results from genetic or epigenetic alterations in the somatic cells and has abnormal cell growth which may be spread to other body parts. In 2018, 18 million cancer was recorded globally in which 9.5 million cancer cases in men, 8.5 million cases in women, and 9.6 deaths were also recorded in the same year. The most spreading cancer globally is prostate, breast, l...

A. Saini, M. Kumar, S. Bhatt, V. Saini and A. Malik *

Department of Pharmaceutics, M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3121-34

3121-3134

28

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9.

POTENTIAL AND PHARMACOLOGICAL ACTIONS OF DHATURA SAFED (DATURA METEL L.): AS A DEADLY POISON AND AS A DRUG: AN OVERVIEW

Plants have great potential for the treatment and management of many diseases and have been used in many countries for the treatment of different diseased conditions. The medicinal value of plants lies in their bioactive phytochemical constituents that produce definite physiological actions in living beings. Many medicinal plants contain some chemical constituents that may cause harmful effects to...

N. Firdaus, U. Viquar * and M. H. Kazmi

Department of Ilmul Advia (Pharmacology), National Research Institute of Unani Medicine for Skin Disorders (NRIUM-SD, Formerly CRIUM), Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3135-49

3135-3149

25

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10.

APPLICATIONS OF NANOROBOTS IN MEDICAL TECHNIQUES

Nanotechnology is going to revolutionize the world. According to the National Nanotechnology Initiative (NNI), nanotechnology refers to the study of all particles in the range of 100 nanometers or less. One of the most important advantages of the smaller particle size is the ratio of surface atoms or molecules to the total number increases. That means they have large surface areas that lead to inc...

S. Mazumder *, G. R. Biswas and S. B. Majee

Department of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata–Group of Institutions, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3150-59

3150-3159

28

16

Research Articles

 
Title
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11.

FORMULATION DEVELOPMENT AND EVALUATION OF CHITOSAN BASED MUCOADHESIVE BILAYERED BUCCAL PATCHES OF CARVEDILOL

Carvedilol is a non-selective β blocker with α1 blocking activity used in the treatment of congestive heart failure, high blood pressure, and left ventricular dysfunction. Following administration by the oral route, it undergoes extensive first-pass metabolism resulting in low bioavailability of 25-35%. The aim of the present study was to incorporate carvedilol in bilayered chitosan containing m...

P. D. Navti *, R. S. Gude, K. G. Dharwadkar and K. V. Naik

Department of Pharmaceutics, Goa College of Pharmacy, Panaji, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3160-71

3160-3171

52

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12.

IN-SILICO TOOLS IN THE PREDICTION OF COUMARIN SCHIFF BASES AS POTENTIALLY ACTIVE COMPOUNDS: A COMPARATIVE STUDY

In the present study two subclasses of coumarin derivatives were selected 14 coumarin sulphonamides and 14 coumarin schiff bases i.e., totally 28 compounds from our earlier research work. A comparative study for two subclasses of coumarins by using various CADD (online and offline) softwares. Computational calculations and predictions of important molecular properties suggest that among the two su...

K. N. V. C. Lakshmi *, B. Anupama, G. Yamini, M. Navyatejasree and M. Saisree

Department of Pharmaceutical Chemistry, QIS College of Pharmacy, Vengamukkapalem, Ongole, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3172-80

3172-3180

34

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13.

SYSTEMATIC DEVELOPMENT OF BINARY ETHOSOMAL NSAID BASED GEL

The present study describes formulation optimization, ­in-vitro evaluation and ex-vivo assessment of indomethacin loaded binary ethosomal gel using central composite design. Two formulation factors, concentration of lipid and concentration of ethanol were optimized for their effects on vesicle size (Y1), zeta potential (Y2), polydispersity index (Y3), entrapment efficiency (Y4) and % cumulative d...

K. Dharwadkar *, R. Gude, K. Naik and P. Navti

Department of Pharmaceutics, Goa College of Pharmacy, Panaji, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3181-96

3181-3196

43

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14.

EFFECTIVENESS OF PHENYLPROPANOID DERIVATIVES AS PRESERVATIVE IN ALUMINIUM HYDROXIDE GEL-USP

A growing concern of microbial resistance and potential risks associated with existing synthetic preservatives have put industries and researchers under immense pressure to develop newer and safer alternatives based on moieties obtained from natural sources. The purpose of this study was to evaluate the preservative effect of the selected derivatives of naturally occurring phenylpropanoids. Alumin...

Neelam, K. K. Sharma, A. Lather and A. Khatkar *

Laboratory for Preservation Technology and Enzyme Inhibition Studies, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3197-03

3197-3203

28

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15.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF CLASS-2 RESIDUAL SOLVENTS IN LULICONAZOLE BY HS-GC

A simple headspace gas chromatographic (HS-GC) method has been developed and validated for the simultaneous determination of residual solvents like methanol, methyl isobutyl ketone, cyclohexane and toluene in luliconazole by Flame ionization detector (FID). The separation was achieved on 30 m long DB-624 column, 0.53 mm in inner diameter, and 3.0 µm in film thickness. The headspace and chromatogr...

G. S. S. V. Madhulika and B. R. Kuber *

Sri Padmavati Mahila Visvavidyalayam, Institute of Pharmaceutical Technology (Women’s University), Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3204-13

3204-3213

38

21

16.

ISOLATION AND STRUCTURE ELUCIDATION OF BIO-ACTIVE COMPOUNDS FROM BOMBAX CEIBA LEAF EXTRACT

Bombax ceiba is a traditional medicinal plant that is beneficial in the treatment of diuretic, hemostatic, antidysenteric, emetic, antipyretic, astringent, and commonly known silk cotton tree, semal, kapok tree. The aim of this study is to isolate and characterize the biologically active compounds from the ethanolic extract of the leaves. The EtOH extract was subjected to silica gel (60-120 mesh) ...

M. Rehan, Shafiullah * and O. Singh

Department of Chemistry, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3214-21

3214-3221

23

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17.

DESIGN AND CHARACTERIZATION OF POLYHERBAL FORMULATION FOR HAIR GROWTH CONTAINING ECLIPTA ALBA, HIBISCUS ROSA-SIENSIS, TRIGONELLA FOENUM-GRAECUM LINN.

Gelling agents such as Carbopol 934 and HPMC K 100 were used in different concentrations for the preparation of Topical polyherbal extract gel formulations containing (%w/w) Eclipta alba, Hibiscus rosa-siensis, Trigonella foenum-graecum Linn. Prepared gel extract of various herbal ingredients were characterized by different parameters like gelling capacity, pH, Homogeneity, Grittiness, Extrudabili...

R. M. Thorat

Vishal Junnar Seva Mandal’s Institute of Pharmacy, Ale, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3222-28

3222-3228

24

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18.

FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF ATENOLOL BY USING NATURAL GUM

The recent work is based on the extraction and purification of natural gum from the bark of plant Terminalia elliptica (local name - Saaj) and the use of this gum to prepare pulsatile Drug Delivery System of Atenolol for the chronotherapy of cardiovascular diseases. Three formulations CF1, CF2, CF3 of core tablets were prepared by direct compression technique by varying concentrations of crospovid...

S. K. Dash *, A. S. Khan, A. Padhan and N. Karna

Department of Pharmaceutics, The Pharmaceutical College, Tingipali, Barpali, Bargarh, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3229-42

3229-3242

23

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19.

COMPARATIVE PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITY OF CALOTROPIS SP. OF ETHNOMEDICINAL SIGNIFICANCE

The global prevalence of infectious diseases caused by microorganisms is a major public health concern worldwide. The emergence of antibiotic resistance and related toxicity issues are limiting the use of antibiotics and prompting research for alternative therapy. Plant-derived drugs are gaining popularity due to their efficacy and safety. Calotropis procera and Calotropis gigantea are two commo...

R. Sethy and B. Kullu *

Department of Botany, Utkal University, Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3243-51

3243-3251

24

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20.

METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATION OF TRIFLURIDINE IN HUMAN PLASMA BY USING LC-MS/MS TECHNIQUE

The main objective of the current study was to develop a highly sensitive LC-MS/MS (liquid chromatography-tandem mass spectrometry) technique for the quantification of trifluridine (TFD) in human plasma. Chromatography was processed on Phenomenex-RP-C18 (5 µm, 250 mm × 4.6 mm) column comprising acetonitrile, methanol and 5 mM ammonium formate (45:40:15, v/v) as a mobile phase, infused at a flow ...

A. S. Mohammad *, F. Ahmad and B. Jayanthi

Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3252-59

3252-3259

23

13

21.

OPTIMIZATION OF PROCESS PARAMETERS FOR IMPROVED PRODUCTION OF BIO-ACTIVE METABOLITES BY ENDOPHYTIC FUNGUS CLADOSPORIUM CLADOSPORIOIDES ISOLATED FROM MANGROVE PLANT LUMNITZERA RACEMOSA LINN.

A study has been undertaken with an aim to isolate potent endophytic fungi from mangrove plant Lumnitzera racemosa Linn. Among the 10 different fungal strains isolated, one potent strain with broad-spectrum antagonistic activity was found. Basing on the morphological, cultural and molecular characteristics, the potent fungal strain was identified as Cladosporium cladosporioides. Production of bioa...

G. V. L. Bhavani and V. Muvva *

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3260-67

3260-3267

25

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22.

ATTENUATION OF QUORUM SENSING ASSOCIATED VIRULENCE FACTORS AND BIOFILM FORMATION IN PSEUDOMONAS AERUGINOSA PAO1 BY PHOMA MULTI-ROSTRATA PUTY3, A SAPROPHYTIC FUNGUS, ISOLATED FROM CARICA PAPAYA

Pseudomonas aeruginosa is one of the most emerging multidrug-resistant opportunistic pathogens, which poses a threat to immunocompromised patients. Treatment of P. aeruginosa in the affected patients has become difficult because of its ability to develop resistant strains against most of the conventional therapeutic antibiotics. Quorum sensing plays a crucial role in the virulence nature of P. aer...

T. Ahmed and V. V. Sarma *

Department of Biotechnology, School of Life Sciences, Pondicherry University, Kalapet, Puducherry, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3268-84

3268-3284

26

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23.

MOLECULAR CHARACTERIZATION OF PROTEIN AND ANTIOXIDANT CAPACITY OF TURBO BRUNNEUS R. CYPRAEA ANNULUS L. AND BABYLONIA SPIRATA L.

The aim of this study was to analyze the molecular weight of protein and in-vitro antioxidant activity of marine gastropods Turbo brunneus, Cypraea annulus, and Babylonia spirata. The molecular weight of the protein was determined using SDS-PAGE, and its antioxidant potential was carried out by DPPH radical scavenging activity, reducing power activity and H2O2 radical scavenging activity. The mole...

P. Subavathy * and S. M. B. Janet

Department of Zoology, St. Mary’s College, Thoothukudi, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3285-93

3285-3293

26

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24.

ANALYSIS OF BIOACTIVE COMPOUNDS PRESENT IN METHANOLIC EXTRACT OF PHYMATOSORUS SCOLOPENDRIA (BURM. F.) PIC. SERM. THROUGH GAS CHROMATOGRAPHY AND MASS SPECTROSCOPY

Phymatosorus scolopendria (Burm. F.) Pic. Serm. belongs to the family Polypodiaceae which is commonly known as musk-fern or wart-fern. Medicinally, the experimental plant possesses insect repellent, anti-inflammatory and bronchodilator activity and hence used ethnomedicinally by tribal people, but was not explored for its bioactive compounds. Hence, the objective of this study was to determine the...

S. Sujatha, S. C. Sara *, M. Gayathiri, I. R. Roselin and R. G. D. Ruby

PG & Research Department of Botany, Holy Cross College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3294-99

3294-3299

27

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25.

EFFECTS OF JUSTICIA GENDARUSSA LEAVES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Justicia gendarussa belongs to the Acanthaceae family. The leaves and young shoots are anti-periodic, antispasmodic, cardiotonic, carminative, diaphoretic, emetic and febrifuge. The presence of phytochemicals such as tannins, alkaloids, proteins, flavonoids, triterpenes and saponins in the ethanolic extract was revealed by the preliminary phytochemical screening, keeping in view of medicinal impor...

B. N. Suresh *, P. V. Satish and R. J. Oswal

Genba Sopanrao Moze College of Pharmacy, Wagholi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3300-05

3300-3305

23

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26.

NANOCURCUMIN SELECTIVELY ACTIVATES ENDOTHELIAL NITRIC OXIDE IN MIDDLE UTERINE ARTERY OF GOAT (CAPRA HIRCUS)

Objective: The present study is designed to investigate vasorelaxation mechanisms of Nanocurcumin in the middle uterine artery (MUA) of both non-pregnant (NP) and pregnant (P) Capra hircus (Ch). Methods: MUA rings were mounted in an automatic organ bath and the contractile response was recorded isometrically by highly sensitive force transducer connected to a power lab data acquisition system. Nan...

H. Jandhyam, P. C. Behera and S. C. Parija *

Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3306-12

3306-3312

24

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27.

BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LENVATINIB BY RP-HPLC METHOD

A rapid, fast, accurate, and precise method was developed for the estimation of lenvatinib in human plasma using methotrexate as an internal standard by reverse-phase high-performance liquid chromate-graphy (RP-HPLC). The separation was carried out by using zodiasil C18 (150 × 4.6 mm, 5 m) as a stationary phase and 0.01 N sodium di-hydrogen phosphate (pH: 4.8): acetonitrile in the ratio of 45:55 ...

G. K. Veni, A. Ajitha * and K. Abbulu

Department of Pharmaceutical Analysis, CMR College of Pharmacy, Medchal, Kandlakoya, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3313-19

3313-3319

25

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28.

FREE RADICAL INDUCED CELL DAMAGE: PROTECTED BY PURIFIED COLEUS AROMATICUS LEAVES PROTEIN

Objective: Many studies have demonstrated the antioxidant properties of extracts of Coleus aromaticus. The purified Coleus aromaticus leaves protein was studied to investigate its in-vitro antioxidant activity, preventing oxidative DNA damage induced by hydrogen peroxide (H2O2) and its protective effect on lymphocyte cell viability. Materials and Methods: In-vitro antioxidant capacity by DPPH assa...

S. K. Nune, A. Nusrath and D. Ramadas *

Adichunchanagiri Institute for Molecular Medicine, CRL-AIMS, Adichunchanagiri University, B.G. Nagara, Mandya, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3320-25

3320-3325

34

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29.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR ESTIMATION OF DARUNAVIR

A simple, precise, and sensitive stability-indicating high-performance thin layer chromatographic (HPTLC) method has been developed and validated for the analysis of Darunavir in bulk and in the tablet dosage form. The separation was performed on pre-coated silica gel 60 GF254 plates using Toluene: Methanol: Triethylamine (8.5:1:0.5 v/v/v) as the mobile phase. The retention factor (Rf) was found t...

A. R. Chabukswar and A. S. Gadekar *

Department of Pharmaceutical Chemistry, MAEERS Maharashtra Institute of Pharmacy, Kothrud, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3326-32

3326-3332

27

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30.

FORMULATION AND EVALUATION OF SUSTAINED RELEASE IN-SITU GEL OF AMIKACIN BY USING 32 FULL FACTORIAL DESIGN

Objectives: This work aimed to formulate and evaluate amikacin, fourth-generation fluoroquinolone antibiotic agent containing an in-situ gelling system based on sol-to-gel transition for ophthalmic delivery to overcome the problems of poor bioavailability and therapeutic response exhibited by conventional formulations based a sol-to-gel transition in the cul-de-sac upon instillation. Methods: In t...

S. Sahoo *, K. Malviya, N. Oza, A. Solanki and Prasanta K. Mohapatra

C. U. Shah College of Pharmacy and Research, Wadhwan, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3333-46

3333-3346

22

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31.

IN-VITRO AND EX-VIVO STUDIES ON SYNERGISTIC EFFECTS OF LIMONIA ACIDISSIMA AND APPLE CIDER VINEGAR ON ANTI-UROLITHIATIC ACTIVITY

Kidney stones are aggregations of minerals such as calcium, oxalate, phosphates, uric acid, cysteine, etc. which can obstruct any part of the urinary system. This can turn fatal if left untreated as the major route of excretion is blocked causing the toxicity level to rise in the body which might lead to organ failure, coma and death. Limonia acidissima (wood apple) and Apple cider vinegar were fo...

K. G. Singh *, G. L. S. Ramya and D. Purohit

Department of Biochemistry, Mount Carmel College, Palace Road, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3347-54

3347-3354

21

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32.

DESIGN AND SYNTHESIS OF BIOLOGICAL ACTIVE N-(5-P-TOLYL-1,3,4-THIADIAZOL-2-YL) BENZAMIDEANDITS DERIVATIVES WITH EVALUATION OF THEIR ANTI-BACTERIAL ACTIVITY

A number of N-(5-p-tolyl-1,3,4-thiadiazole-2-yl) benzamide derivatives were synthesized from aromatic acid. The antibacterial activity of these newly synthesized N-(5-p-tolyl-1,3,4-thiadiazole-2-yl) benzamide derivatives against Gram-positive bacteria and Gram-negative bacteria was also studied using the minimum inhibition concentration method. The synthesized compounds were showed better results ...

A. Singh *, M. Farooqui, M. F. Diwan and R. K. Pardeshi

Dr. Rafiq Zakaria College for Women, Navkhanda, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3355-59

3355-3359

24

11

33.

IDENTIFICATION OF NOVEL NATURAL MOLECULE FROM METHANOLIC STEM BARK EXTRACT OF PARKINSONIA ACULEATA

Parkinsonia aculeata (family - Caesalpiniaceae) is a large spinous shrub found in warmer regions of the world. It is a well known medicinal plant that has significant and promising biological activities such as antioxidant, anti-inflammatory, antidiabetic, antispermatogenic, etc. The phytochemical investigations of the leaves, flowers, and stem have revealed the presence of various glycosides, fla...

S. Rao *, A. K. Sharma, M. P. Dobhal and M. C. Sharma

Department of Chemistry, Sophia Girls College (Autonomous) Ajmer, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3360-66

3360-3366

27

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EXPLOITING NATURAL POLYMER REINFORCED MICROSPHERES AND INVESTIGATING ITS CHARACTERISTICS FOR SUSTAINED RELEASE

The objective of current research work is exploring the use of natural mucilage for sustained release characteristics for the formulation of microspheres. Orifice ionic gelation method was used to formulate the microspheres by using complex-forming polymer sodium alginate in combination with isolated mucilage. Mucilage from Colocacia esculenta corms were isolated and combined with sodium alginate ...

U. Y. Kandekar

Department of Pharmaceutics, PES Modern College of Pharmacy (For Ladies), Moshi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3367-78

3367-3378

29

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35.

ISOLATION AND TAXONOMIC CHARACTERISATION OF POTENTIAL ANTAGONISTIC SIMPLICILLIUM LANOSONIVEUM VJCH-19 FROM MANGROVES OF ADAVULADEEVI, ANDHRA PRADESH, INDIA

Objectives: The intention of the present study was to isolate and identify cultural conditions of potent fungal strain VJCH-19 with antagonistic activities isolated from mangrove ecosystems of Adavuladeevi, South coast, Andhra Pradesh, India. Methods: The soil samples were collected from the mangrove habitats and shade dried. The serial dilution plate technique was employed for the isolation of ma...

C. Chiranjeevi and V. Muvva *

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3379-84

3379-3384

25

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36.

EFFECT OF SOLVENTS ON ANTIOXIDANT ACTIVITIES OF FERONIA LIMONIA FRUIT

Feronia limonia (F. limonia) is an underutilized edible fruit commonly known as kaitha. The study was performed to compare the effect of three solvents at different concentrations on antioxidant activities of F. limonia fruit. Fruits were extracted in different solvents viz., ethanol, methanol, and acetone at concentrations of 50%, 70%, and 90%. Each extract was analyzed for total phenol and flavo...

R. Srivastava, N. Mishra, S. Tripathi and N. Mishra *

Department of Home Science, University of Allahabad, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3385-91

3385-3391

22

15

37.

SENSITIVE AND RAPID SIMULTANEOUS QUANTITATION OF RALOXIFENE AND ITS TWO MAJOR ACTIVE METABOLITES 4-GLUCURONIDE RALOXIFENE AND 6-GLUCURONIDE RALOXIFENE IN HEALTHY VOLUNTEERS USING A LIQUID CHROMATOGRAPHY COUPLED WITH TRIPLE QUADRUPLE MASS SPECTROMETER

Simultaneous estimation of parent and its metabolite(s) in a single method poses a threat when one has to monitor one mass transition while running the other compound on liquid chromatography-mass spectrometer. This would again become critical once interference is observed at the retention time of compound of interest in-spite of its absence in the sample. In this paper, a selective and sensitive ...

N. K. Dubey *, P. Jain and B. I. Fozdar

Jubilant Generics Limited, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3392-02

3392-3402

23

13

38.

ANTIMICROBIAL STUDIES OF NEW RARE EARTH METAL(III) COMPLEXES OF SCHIFF BASE LIGANDS WITH 1-H INDOLE-(2, 3-DIONE): SYNTHESIS, PHYSIO-CHEMICAL, MAGNETIC, ELECTROCHEMICAL AND SPECTRAL STUDIES

New complexes of La (III) and Nd (III) with bidentate Schiff base ligands, 1-H indole-(2, 3-dione) hydrazinecarbothioamide (L1H), 1-H indole-(2, 3-dione) hydrazinecarboxamide (L2H) have been synthesized and characterised. The stoichiometry of the complexes is originated in the type of [Ln (L1, 2) 3].3H2O for both metals. The characterization and nature of bonding of these complexes were elucidated...

P. K. Mitharwal, A. Kumari and R. V. Singh *

Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3403-08

3403-3408

20

16

39.

DESIGN, DEVELOPMENT AND EVALUATION OF GASTRIC FLOATING IN-SITU GEL OF PIROXICAM

The present study involves the formulation and evaluation of floating in-situ gel containing piroxicam for the treatment of arthritis. In the FTIR and DSC study for compatibility of piroxicam with polymers, there are no significant changes observed so it is confirmed the absence of drug-polymer interactions. The gastric floating in-situ gel was prepared by using Sodium Alginate, HPMC K 200 M &...

N. S. Siraj *, G. J. Vrushabha and G. J. Khan

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3409-16

3409-3416

26

12

40.

FORMULATION, DEVELOPMENT AND OPTIMIZATION OF DAPSONE DEPOT INJECTION IN ACNE: IN-VITRO/IN-VIVO STUDY

The aim of this work is to design and develop a controlled release drug delivery system of the anti-acne agent (dapsone), also used as a leprostatic agent. Dapsone is a strong anti-inflammatory agent that makes it a more powerful treatment in dermatological disorders; its treatment in acne requires long term steady-state concentration in plasma. Poor patient compliance and long term treatment by a...

N. Acharya *, P. Shah, G. Patel and S. K. Srinivasan

Department of Pharmacognosy Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3417-26

3417-3426

22

14

41.

INCIDENCE AND ANTIBIOTICS SUSCEPTIBILITY PATTERN OF BACTERIA OF EAR ORIGIN

This study is aimed at investigating both the Gram-positive and the Gram-negative bacteria of ear swabs and their antibiotic susceptibility pattern. Ear samples of one hundred (100) subjects using sterile swab sticks were collected. Sixty-seven (67) out of 100 samples collected yielded growth when incubated at 37 ºC for 24 h. Microbiological tests were carried out to characterize the bacterial is...

C. O. Anie *, F. O. Enwa, M. I. Iyamu and P. E. Asoro

Department of Pharmaceutical Microbiology, Delta State University Abraka, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.11(7).3427-32

3427-3432

23

11

42.

MICROENCAPSULATION: A STRATEGY TO SURPASS PHOTO INSTABILITY AND LOW PENETRABILITY OF SKIN LIGHTENING AGENTS

Objective: Kojic acid and arbutin are potent agents for effective treatment of hyperpigmentation. However, low photostability, low permeability and high irritancy exhibited by them make topical delivery a challenge. The aim of this study was to develop novel photostable and highly penetrable formulation of kojic acid and arbutin to combat hyper-pigmentation effectively at lower concentrations in c...

D. Prabhu * and P. Ravikumar

Department of Pharmaceutics, SVKM’s, Dr. Bhanuben Nanavati College of Pharmacy, Mithibai Campus, Vile Parle (W), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3433-41

3433-3441

24

12

43.

STABILITY INDICATING RP-UPLC-DAD METHOD FOR DETERMINATION OF METFORMIN AND CANAGLIFLOZIN IN BULK AND TABLET DOSAGE FORM

The objective of the present work is to develop and validate a novel stability-indicating RP-UPLC-DAD method for the simultaneous analysis of Metformin and Canagliflozin in bulk and tablet dosage form. The chromatographic separation was accomplished on a Waters UPLC system equipped with autosampler and PDA detector. A volume of 5 µL of sample or standard was injected into the column and the analy...

N. Padmaja and G. Veerabhadram *

Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3442-49

3442-3449

24

11

44.

HPTLC FINGER PRINT PROFILE OF ROOT EXTRACTS OF MARTYNIA ANNUA LINN.

The objective of the present study is to evaluate phytochemical composition and HPTLC finger print profile of medicinally useful plant Martynia annua L. (Martyniaceae) root extracts. The CAMAG HPTLC system was used for the finger print profiling of root extract using the mobile phase chloroform: Methanol (9:1 v/v). The profile showed that the root extract of Martynia annua exhibited several peaks ...

R. K. Gupta * and M. Deogade

Department of Dravyaguna, MGACH & RC, Wardha, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3450-56

3450-3456

22

13

45.

SECONDARY METABOLISMS OF BIOACTIVE COMPOUNDS FROM ACACIA CATECHU STEM BARK METHANOLIC EXTRACT

The main objective of this research work was to check the presence or absence of the phytochemical chemicals in all the selected medicinal plant. Phytochemical analysis of these plants confirm the presence of various phytochemicals like saponins, tannins, amino acids, phenols, carbohydrates, proteins, flavonoids, steroids, alkaloids and glycosides. A. catechu extract are analyzed by using TLC with...

P. Sasikala, K. Pukazhendhy * and G. Jagadeesan

Department of Zoology, University of Madras Guindy Campus, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3457-62

3457-3462

25

13

46.

EVALUATE THE EFFECT OF BACOPA MONNIERI, EVOLVULUS ALSINOIDES AND TINOSPORA CORDIFOLIA ON BIOCHEMICAL PARAMETERS IN RATS BRAIN

Bacopa monnieri, Tinospora cordifolia, and Evolvulus alsinoides are conventional Ayurvedic floras that are useful in the various neuropharmacological ailment. This research focused on the effect of ethanolic extract of Bacopa monnieri (BME), Tinospora cordifolia (TCE), and Evolvulus alsinoides (EAE) were evaluated alone and in a combination of extracts (CEPs) by using scopolamine-induced oxidative...

A. Gupta *, M. P. Singh and S. S. Sisodia

Department of Pharmacology, Bhupal Nobles’ College of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3463-68

3463-3468

20

12

47.

Cr AND Pb CONTAMINATION IN AGRICULTURAL SOIL IN TWO DIFFERENT SEASONS AND THREE DEPTH OF THE SOIL LAYER SAMPLES NEARBY TANNERY WASTE DISPOSAL ZONES AT RANIPET, VELLORE DISTRICT IN THE SOUTHERN INDIA

This paper investigates the determination of trace metals named Chromium and Lead set down in the soil as well as in the groundwater due to the tanning industries area of Ranipet town, Vellore city. The tanneries discharge untreated tannery effluents, which get mixed with the soil, water of the Palar river, and underground in this area. The determination of metals was performed for the soil that ...

A. Kistan * and V. Kanchana

Department of Chemistry, Sree Sastha Institute of Engineering and Technology, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3469-73

3469-3473

22

10

48.

SOLUBILITY ENHANCEMENT AND OPTIMIZATION OF VARIOUS VARIABLES OF FAST DISINTEGRATING TABLETS OF LERCANIDIPINE HYDROCHLORIDE USING CENTRAL COMPOSITE DESIGN

The oral route of drug administration is the most common and preferred method of delivery due to convenience and ease of ingestion, but it is problematic if the drug is poorly soluble. Sufficient drug absorption, reproducible bioavailability and pharmacokinetic profile of orally administered drug substances are highly dependent on the solubility of that compound in an aqueous medium. Also, the the...

S. Saini * and R. Garg

IKG Punjab Technical University, Jalandhar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3474-82

3474-3482

26

11

49.

PHYTOPHARMACOGNOSTICAL STUDY OF TUBERS OF EULOPHIA NUDA LINDL.

Plants and plants-based medicines have been used to treat many ailments since the ancient times.  Family Orchidaceae to which orchids belongs is the largest family among monocotyledons. The genus Eulophia comprises perennial terrestrial orchids with fleshy tubers, rarely pseudobulbs. One such perennial herb having underground tubers, Eulophia nuda, belonging to family Orchidaceae, has been tradit...

D. Bhatt *, K. Jethva and M. Zaveri

Department of Pharmacognosy, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3483-88

3483-3488

24

14

50.

PRELIMINARY QUALITATIVE PHYTOCHEMICAL, PHYSICO-CHEMICAL AND PHYTO-PHARMACOGNOSTICAL STANDARDISATION EVALUATION OF THE PULP (WITHOUT SEED), PERICARP, LEAVES AND SEED OF AEGLE MARMELOS L. (BAEL).

Aegle marmelos L. (Bael), is a commonly occurring herb which has biomedical potency to treat many types of diseases such as diarrhea, hepatoprotective, epilepsy, stomachalgia, digestion related problems etc. The different parts of Aegle marmelos (L.) were collected, dried and coarsely powdered. The present study deals with the physio-chemical constants standardization parameters such as pH, solubi...

S. L. Shakyawar *, M. A. Rahman, S. Sundaram and S. Alok

Centre of Biotechnology (CBT), Science Faculty, University of Allahabad, Prayagraj (Allahabad), Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3489-06

3489-3506

24

15