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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 6 (2015) - Issue 1, January

Review Articles

 
Title
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1.

SOME DRUGS IN ACTION: METAL IONS DO INFLUENCE THE ACTIVITY!

A large no of synthetic and natural compounds behave as very effective drugs. All these compounds have a wide range of biological activities like anti-bacterial, anti-fungal, anti-cancer, anti-viral, anti-inflammatory, anti-neoplastic, anti-tumorigenic, anti-HIV and so on. On the other hand, metals have played an important role in medicine for years. Many are essential in our diets in varying quan...

Kangkana Sarkar and Kamalika Sen*

Department of Chemistry, University of Calcutta, 92 APC Road, Kolkata 700009, West Bengal, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).1-13

1-13

3021

1869

2.

CHITOSAN & ITS DERIVATIVES: A REVIEW IN RECENT INNOVATIONS

Chitosan a natural polymer available and easy to produce in countless parts of the world; is a material that can significantly improve the standard of living in developing countries where the industry is often surpassing the need to protect the environment and/or where the environment protection is strongly dependent on limited financial resources available to those in charge of environmental prot...

Shakeel Ahmed and Saiqa Ikram*

Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi - 110025, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).14-30

14-30

7967

1915

3.

INTRINSIC MITOCHONDRIAL APOPTOTIC PATHWAYS; AN IMPERATIVE FEATURE OF CISPLATIN CYTOTOXICTY

Up till now, the most thriving and extensively used antineoplastic agent with well-established effectiveness is cisplatin. Being a non-specific drug, it reacts not only with genomic DNA but also binds and damages the plasma protein and cytoplasmic protein that confers to cisplatin resistance and severs side effects. DNA damage prompted by cisplatin leads to the activation of many signaling cascade...

Maria Fareed Siddiqui*, Esha Sadiq and M.H. Qazi

Centre for Research in Molecular Medicine (CRiMM), University of Lahore, 1 km Defense Road Lahore, Pakistan.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).31-41

31-41

2216

674

4.

RECENT INNOVATIVE APPROACHES TO ENHANCE THE EFFICACY AND SAFETY OF ANTICANCER DRUGS: A COMPREHENSIVE REVIEW

Developing innovative delivery strategies remains an ongoing task to improve bothefficacy and safety of drug-based therapy. Anti-cancer drug treatment is seriously affected by various undesirable properties such as poor solubility, narrow therapeutic index and efflux transporter specificity. One of the primary aspects of a successful cancer treatment regimen is to deliver sufficient amounts of dru...

Rishi Kant Pandey*, Amit Bihan, Rajul Rastogi and Hans J. Gamperl

Department of Global Vigilance, Fresenius Kabi Oncology Ltd., Echelon Institutional Area, Plot No-11, Sector-32, Gurgaon Pin Code-122001, Haryana, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).42-49

42-49

2372

842

5.

A REVIEW ON ENDEMIC INDIAN RESURRECTING HERB SELAGINELLA BRYOPTERIS (L.) BAK. ‘SANJEEVANI’

Selaginella bryopteris (L.) Bak. usually known as “Sanjeevani’, is a lithophyte with remarkable resurrection capabilities and medicinal properties. It is traditionally used for curing wounds and irregular menstruation, uterine disorders and other internal injuries. It contains a variety of secondary metabolites such as alkaloids, phenol and terpenoids etc due to which it can act as antioxidant...

Shweta Singh* and Rita Singh

Post Doctoral Fellow of UGC, Guru Gobind Singh Indraprastha University, University School Of Environment Management, 16 C Dwarka, New Delhi-110078, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).50-56

50-56

5296

2002

6.

NANOPARTICLE TECHNOLOGY: FORMULATING POORLY WATER-SOLUBLE COMPOUNDS: A REVIEW

One of the biggest challenges faced by pharmaceutical scientists is poor solubility and bioavailability of new chemical entities (NCEs). According to BCS classification; approximately 25% of all compounds are classified as highly soluble and permeable. Nearly 40% of the new chemical entities currently being discovered are lipophilic so poorly water soluble drugs. BCS Class II and Class IV have low...

Rashmi Sharma *, Saroj Jain and Ravindra Tiwari

Department of Pharmaceutics , Hindu College of Pharmacy, Sonepat, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).57-71

57-71

3198

1523

7.

A REVIEW ON MEDICINAL IMPORTANCE OF EMBLICA OFFICINALIS

Research in medicinal plants has gained a renewed focus recently. The prime reason is that other system of medicine although effective come with a number of side effects that often lead to serious complications. Plant based system of medicine being natural does not pose any serious problems. Although Emblica officinalis has a range of medicinal applications, but it is the need much period of time ...

R. Jain *, R. Pandey, R. N. Mahant and D.S. Rathore

Department of Biotechnology, Government Kamala Raja Girls Post Graduate (Autonomous) College, Gwalior (M.P.), India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).72-84

72-84

19794

2429

8.

REGULATION OF NON-CANONICAL WNT SIGNALING PATHWAY IN STEM CELLS DEVELOPMENT AND CARCINOGENESIS

Since 1982, Wnt1 (Wingless int-1) was first identified in mammary carcinoma. Further, Wnt signaling pathway was discovered. Wnt signals were involved in stem cells development, regeneration, cell cycle and repair mechanism. Finally abnormality Wnt signals were stimulated variety of cancers. Especially, non-canonical signaling pathways such as Wnt/PCP and Wnt/Ca2+ pathway were involved in developme...

Rajendran Prakash* and Rattinam Rajesh

Research Student Department Of Biotechnology Vmkv Engineering College Vinayaka Missions University Salem, Tn, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).85-90

85-90

2386

754

9.

NEUTRACEUTICALS AS ADJUNCT TREATMENT DURING CHEMO- OR RADIO-THERAPY FOR CANCER: A REVIEW

Today, Proliferation is being observed in neutraceutical industry due to health seeking consumer trend.Neutraceutical has evolved from health promoting to disease preventing supplements. Various herbs and their phytochemicals discussed in the present review can prove potent neutraceuticals as they are pharmacologically safe and provide advantages in terms of suppressing tumor progression, increasi...

Priyanka Gupta

Rajiv Gandhi Biotechnology Centre, L.I.T. Campus, RTM Nagpur University, Nagpur, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).91-95

91-95

3070

811

Research Articles

 
Title
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10.

DETERMINATION OF A POORLY SOLUBLE DRUG, IBUPROFEN IN RAT PLASMA BY A SIMPLE HPLC ANALYSIS AND ITS APPLICATION IN PHARMACOKINETIC STUDY

In this study, a reversed-phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantification of ibuprofen in rat plasma. The mobile phase consisted of a mixture of acetonitrile and water that was adjusted to pH 2.5 using orthophosphoric acid (70:30). The flow rate was set at 0.5 ml/min and effluent was monitored by using UV detector at a wavelength of 223 nm wi...

A. Nurfazreen, B. E. Tommy Julianto and A. H. Khuriah*

Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA, 42300, Puncak Alam, Selangor, Malaysia.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).96-102

96-102

2606

1218

11.

FACILE SPECTROPHOTOMETRIC DETERMINATION OF METRONIDAZOLE AND SECNIDAZOLE IN PHARMACEUTICAL PREPARATIONS BASED ON THE FORMATION OF DYES

A rapid and sensitive spectrophotometric method is proposed for the determination of Metronidazole and Secnidazole drugs. The method depends on the reduction of Metronidazole and Secnidazole molecules with zinc dust and hydrochloric acid followed by diazotization and coupling with α-naphthylamine to give red colored chromogens easily measured spectrophotometrically at λmax = 510 nm or coupling w...

Ahmed K. Youssef, Magda M. S. Saleh, Doaa A. Abdel-Kader and Elham Y. Hashem*

Department of Analytical Chemistry, Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).103-10

103-110

2410

869

12.

MORPHO-ANATOMIC INVESTIGATION OF VEGETATIVE ORGANS OF WATER AVENS (GEUM RIVALE L.)

Species of Geum L. genus (avens) of Rosaсeae L. family belong to perspective sources of medicinal plant raw material for obtaining medicines with the anti-microbic and anti-inflammatory action. They are characterized by such an important feature as the presence of biologically active substances, particularly the polyphenol compounds. According to the aim of present work, morphologic and anatomic...

M.A. Kulagina*, S.A. Kozyra, E.V. Radko and T.M. Gontova

Department of Botany, National University of Pharmacy, 61168, Str.Blucher, 4, Kharkov, Ukraine.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).111-16

111-116

1904

734

13.

ANTIMICROBIAL, CYTOTOXICITY, FREE RADICAL SCAVENGING ACTIVITIES AND COMPOUNDS ISOLATED FROM THE ROOTS OF HEMIDESMUS INDICUS (LINN.) R. BR.

Hemidesmus indicus Linn. R. Br. is a twining shrub traditionally used for the treatment of various diseases and ailments in the rural area of Bangladesh.  Different extracts (methanol, hexane, ethyl acetate, n-butanol and water) from the roots of this shrub tested for their antimicrobial, cytotoxicity and free radical scavenging activities. All extracts showed moderate free radical scavenging act...

A. Saha, J. Tasnim , S. Ahmed , T. Muslim , M. A. Rahman and N. Sultana *

Principal Scientific Officer Institute of National Analytical Research and Service (INARS), BCSIR Laboratories Dhaka, Dr. Qudrat-i-Khuda Road, Dhanmondi, Dhaka-1205, Bangladesh.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).117-22

117-122

2193

1199

14.

NEUROPROTECTIVE EFFECT OF EXTRACT OF ANACARDIUM OCCIDENTALE LINN ON A ROTENONE MODEL OF PARKINSON´S DISEASE

In this study the neuroprotective activity extract hydroalcoholic of AO against behavioral and biochemical parameters induced by subcutaneous injection of rotenone was evaluated, important for the understanding of Parkinson´s disease, which is the most common neurodegenerative disorder affecting movement. Rotenone is a potent hydrophobic pesticide and a highly selective inhibitor of complex I in ...

Cybelle Facanha Barreto Linard-Medeiros , Victor de Albuquerque Wanderley Sales , Adriano Costa Ramos , Adriana Sereniki, Maria Teresa Salles Trevisan , Almir Gonçalves Wanderley and Simone Sette Lopes Lafayette *

Department of Physiology and Pharmacology, CCB, University Federal of Pernambuco, Av. Prof. Moraes Rego, s/n, CEP 50670-901 – Cidade Universitária, Recife, PE, Brazil

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).123-29

123-129

2528

776

15.

PREVALENCE AND FACTORS ASSOCIATED WITH HIV AND HEPATITIS B VIRUS INFECTIONS AMONG FEMALE COMMERCIAL SEX WORKERS IN MEKELLE, ETHIOPIA: CROSS SECTIONAL STUDY

Background: Sexually Transmitted Infections remain major public health problems among the most at risk population groups such as female commercial sex workers. Objective: To assess the magnitude of Hepatitis B Virus and HIV/AIDS and identify the associated factors among female commercial sex workers. Methodology: A Community Based Cross Sectional Study was conducted in Mekelle city. A total of 319...

Gessessew Bugssa *, Berhe Dessalegn, Balem Dimtsu and Yemane Berhane

Lecturer, Institute of Biomedical Sciences, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).135-46

130-146

1976

807

16.

ANTI NOCICEPTIVE ACTIVITY OF ARGENTUM NITRICUM, STAPHYSAGRIA, IGNATIA AMARA IN MICE IN COMPARISON WITH ACETYL SALICYLIC ACID (ASPIRIN)

Pain is a condition that is experienced by everybody in its life irrespective of humans or animals, reason could be due to any intense stimuli. It is a common phenomenon in vertebral animals similar to that felt by humans. This study was designed to determine theanalgesic activity of Argentum Nitricum, Staphysagria and Ignatia Amara in comparison with Acetyl salicylic acid. For this purpose the me...

Humera Anser * and Rahila Najam

Assistant Professor, Department of Pharmacology, Faculty of Pharmacy, Jinnah University For Women. Karachi, Pakistan.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).147-53

147-153

2382

693

17.

MANAGEMENT OF ANTIMALARIAL DRUGS IN THE URBAN PUBLIC HEALTH FACILITIES IN TANZANIA

Frequent drug shortage, poor storage conditions and inadequate knowledge of health care workers for inventory management are among the factors affecting the supply chain of antimalarial drugs in Tanzania. These factors largely contribute to poor quality, shortage and irrational use of antimalarial drugs in the public health facilities. The aim of this study was to assess the management of ant...

Richard Silumbe and Appolinary A. R. Kamuhabwa *

P.O. Box 65013, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam Tanzania.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).154-63

154-163

2270

849

19.

MOLECULAR DOCKING SIMULATION STUDY OF PHYTOESTROGENS FROM ASPARAGUS RACEMOSUS IN BREAST CANCER PROGRESSION

Phytoestrogens are the xenoestrogens which are derived from the plant. This is the first report providing the deeper inside into the mechanism involved in restricting breast cancer progression with the help of docking simulation by phytoestrogen. Docking experiment bring to light that phytoestrogens prevents the binding of oestradiol with its receptor, thereby down regulating the signalling pathwa...

Ramit Singla and Vikas Jaitak*

Centre for Chemical and Pharmaceutical Sciences, School of Basics and Applied Sciences Central University of Punjab, Bathinda (Punjab)-151001 India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).172-82

172-182

2693

942

20.

EXPERIMENTAL DESIGN APPROACH TO OPTIMIZATION OF THE NEW COMMERCIAL RP-HPLC DISCRIMINATION CONDITIONS FOR THE ESTIMATION OF PARACETAMOL AND ZALTAPROFEN IN PHARMACEUTICAL FORMULATION

A simple, rapid, RP-HPLC method developed for the simultaneous estimation of paracetamol and zaltaprofen in commercial pharmaceutical formulation by applying Derringer’s desirability function. The dependent variables such as Capacity factor of first peak, α value and retention time of tR3 as the responses with three important independent factors of organic phase composition, pH of mobile phase ...

R. Sathiyasundar * and K. Valliappan

Department of pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, TN 608002, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).183-89

183-89

1807

712

21.

CARDIOPROTECTIVE ROLE OF AMLODIPINE UNDER ACUTE HYPOBARIC HYPOXIA: ROLE OF AKT-1 IN REDOX BALANCE

Hypobaric hypoxia induced systolic heart dysfunction and arrhythmia is prevalent in ascendants. L-type calcium channel blocker amlodipine plays important role in modulating cardiac function. We tested if amlodipine could impart cardio protection and restore oxidative balance under hypobaric hypoxia, by modulating HIF-1α activity and calcium accumulation, thus, protects from cardio-toxicity. Exper...

S. Nehra, V. Bhardwaj, M. Singh, K. Singh and D. Saraswat *

School of Studies in Chemistry, Jiwaji University, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.6(1).190-99

190-199

48

17

22.

OCTENYL SUCCINATE CASSAVA STARCH AS AN EXCIPIENT FOR CONTROLLED RELEASE OF THEOPHYLLINE: MICROWAVE-ASSISTED SYNTHESIS, CHARACTERIZATION AND IN-VITRO DRUG RELEASE STUDIES

Octenyl succinate derivatives (OSA) of cassava starch having different degree of substitution (DS) were synthesized by microwave irradiation in solid state using a monomode reactor and the drug, theophylline (Thp) was successfully incorporated in the modified starches for getting controlled release properties. The reaction conditions were optimized for maximizing the DS by response surface methodo...

Geetha K. Athira and Alummoottil N. Jyothi*

Division of Crop Utilization, Central Tuber Crops Research Institute Sreekariyam, Thiruvananthapuram, Kerala, India. Pin-695017, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).200-11

200-211

1999

1148

23.

NOVEL 2 – AMINO – N’ – (2-OXOINDOLIN – 3 – YLIDENE) BENZO [d] OXAZOL – 5 -CARBOHYDRAZIDES AS ANTI-INFLAMMATORY AGENTS

In the present work , novel 2-Amino-N'-(2-oxoindolin-3-ylidene) benzo[d]oxazole-5-carbohydrazides were synthesized and  evaluated for In-vivo anti-inflammatory activity by carragenan induced rat paw edema method and were known to exhibit promising anti-inflammatory activity at a  dose of 30mg/kg bw. Compounds D2, D3, D5 and D8 were found to be comparatively potent with the standard Indomethacin....

A. Lavanya *, Arunadevi Parlapalli, Manasa Ciddi and Sarangapani M

University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).212-18

212-218

1620

965

24.

DEVELOPMENT AND VALIDATION OF BIO-ANALYTICAL RP-ULTRA FAST LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF CLOPIDOGREL AND ROSUVASTATIN IN HUMAN PLASMA

ABSTRACT: This manuscript describes a simple, sensitive, rapid and precise Ultra fast liquid chromatographic (UFLC) method was developed and validated for the simultaneous determination Clopidogrel and Rosuvastatin in human plasma according to USFDA draft guidelines. In the current study, the analysis was performed on phenomenex C8 (250 × 4.6mm, 5μm) column using phosphate buffer (pH-2.5) and ac...

Jinesh Bahubali Nagavi *and Bannimath Gurupadayya

Department of Pharmaceutical Analysis, JSS College of Pharmacy, JSS University, Mysore 570015, Karnataka, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).219-25

219-225

1942

701

25.

ASSESSMENT OF MEDICATION ERRORS IN PSYCHIATRY PRACTICE IN A TERTIARY CARE HOSPITAL

Objectives: To determine the incidence, causes, patterns, outcomes and predictors of medication errors (ME) in psychiatric practice. Methodology: A prospective observational study was conducted in the psychiatry department of a tertiary care hospital over a period of 6 months. Patients of either sex and aged ≥ 18 years receiving at least one psychotropic agent were included in the study and anal...

K. Hema Sahithi, Ibrahim Mohammad, J. Manoranjani Reddy, G. Nandha Kishore, M. Ramesh* and Juny Sebastian

Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Mysore 570 015, Karnataka, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).226-32

226-232

2841

775

26.

EVALUATION OF BIOACTIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF SOME WILD FRUITS BY IN-VITRO ASSAYS

The present study aimed to evaluate bioactive compounds and total antioxidant activity of differentfruits viz Phyllanthus emblica, Limonia acidissima, Syzygium cumini, Artocarpus hirsutus, Carissa congesta, Anacardium occidentale. Phytochemical study confirms the presence of carbohydrates, proteins, amino acids, cardiac glycosides, steroids, terpenoids and flavonoids in all the fruit extract. Asco...

Nayak Srividya * and M. Chandra

Department of Biotechnology, Manipal Institute of Technology, Manipal 576104, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).233-38

233-238

1715

897

27.

SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND EVALUATION OF ANTI-TUMOR PROPERTIES OF NOVEL FATTYACID CONJUGATES OF 2, 4 AND 2, 6-DIISOPROPYLPHENOL

The present study enumerates the synthesis, spectroscopic characterization, and evaluation of antitumor properties of esters of two fatty acids viz., 5-hexenoic acid and iso- ricinoleic acid with 2, 4- or 2, 6-diisopropylphenol (Propofol). Propofol is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit...

Fauzia Bano Faruqi* and Jamal Mustafa

Department of Applied Chemistry, Aligarh Muslim University, A.M.U, Aligarh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).239-46

239-246

1718

644

28.

ISRADIPINE ENHANCES THE ANTICONVULSANT ACTIVITY OF CARBAMAZEPINE AGAINST MES AND PTZ INDUCED CONVULSIONS IN RATS

The aim of this study was to investigate the possible anticonvulsant effect of a Dihydropyridine calcium antagonist, Isradipine, which easily crosses the blood–brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures and PTZ induced seizures. The seizures were induced in rats by maximum electroshock method and...

K. Venugopal Reddy , M. Arun Kumar and G. Vijay kumar *

Assistant Professor of Pharmacy Department of pharmaceutical chemistry, Jangaon Institute of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India 506009.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).247-50

247-250

1887

583

29.

STRUCTURE ELUCIDATION AND ANTIHEPATOTOXIC ACTIVITY OF CIS AND TRANS ISOMERS OF PIPERINE ISOLATED FROM DRIED FRUITS OF PIPER LONGUM

The two pure phytochemicals characterized as cis-piperine and trans-piperine isolated from the dried fruits of Piper longum were tested for antihepatotoxic activity at the dose of 50 mg/kg orally respectively, against silymarin as a standard reference. The toxicity was induced by CCl4, and then various biological parameters such as AST, ALT, ALP, SOD, GPx, GSH, total protein, total albumin and tot...

Khushbu Tripathi*, ND Pandey and Bahar Ahmed

Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).251-58

251-258

2217

806

30.

THE ANTIANGIOGENIC, ANTIOXIDANT AND PROAPOPTOTIC CHEMOPREVENTIVE PROPERTIES OF TANNINS FROM MEMECYLON MALABARICUM (Cl.)

Tannins, the non-nutritive substances from plant sources exhibit potent biological activities that lower the risk of chronic diseases without any side effects. Tannins are most abundant and multipotent molecules exhibiting antioxidant, proapoptotic and antiangiogenic activity and thus being effective in the treatment of degenerative diseases including initiation and progression of tumors.   The ...

N.D. Rekha , S. M. Aradhya and K. Jayashree *

Professor Department of Pathology JSS Medical College JSS University, Shivarathreeshwara Nagara, Mysore – 570015, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).259-66

259-266

2387

980

31.

ISOLATION OF COUMARIN COMPOUND FROM THE BARK OF BAUHINIA PURPUREA

Objectives: The study aimed to isolate coumarin compound from Bauhinia purpurea bark. Method: The bark was extracted successively with methanol in a soxhlet apparatus. The crude mass was subjected to HPLC, as well as column chromatography and eluted with methylene dichloride – methanol system with increasing methanol ratio to isolate compound BP. The structure of compound BP was identified by va...

S. Pahwa *, R. Mazumder and S. Bhattacharya

Associate Professor Lloyd School of Pharmacy, Lloyd Institute of Management and Technology, 11, Knowledge Park-II, Institutional Area, Greater Noida-201306, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).267-72

267-272.

2822

960

32.

SCREENING OF AN INDIGENOUS MEDICINAL PLANT – MADHUCA LONGIFOLIA FOR ITS ANTIOXIDANT AND ANTIMICROBIAL PROPERTIES

Madhucalongifolia is an economically important medicinal tree growing throughout the subtropical region. This research article deals with the antioxidant and antimicrobial properties of M. longifolia.  The antioxidant properties of the seed were determined by hydrogen peroxide scavenging activity and reducing power assay. The methanol extract exhibited more antioxidant activity than water extract...

U. Umadevi and M. Kamalam *

Department of Botany, PSGR Krishnammal College for Women, Coimbatore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).273-76

273-276

1606

599

33.

A KINETIC AND MECHANISTIC APPROACH TO PROTECTION AND REPAIR OF TERT-BUTOXYL RADICALS INDUCED URACIL RADICALS BY CHLOROGENIC ACID

The rates of oxidation of uracil and chlorogenic acid (CGA) by tert-butoxyl radicals have been studied by measuring the absorbance of uracil at 258 nm and CGA at 328 nm spectrophotometrically. tert-butoxyl radicals are generated by the photolysis of tert-butyl hydroperoxide in presence of tert-butyl alcohol to scavenge ·OH radicals. The rates and the quantum yields (f) of oxidation of CGA by t-Bu...

G. Vijayalakshmi *, M. Adinarayana and P. Jayaprakash Rao

University College of Technology, Osmania University, Hyderabad, 500 007, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).277-85

277-285

1632

631

34.

EVALUATION OF ANTI-MICROBIAL ACTIVITY AND WOUND HEALING OF KEFIR

Objective: Pseudomonas aeruginosa has emerged as an important cause of serious wound infection and death in burn patients. There are a limited numbers of antimicrobial agents affecting the bacterium due to its inherent resistance. Kefir is a natural probiotic which contains diverse spectrum of bacteria, yeasts and their metabolites with potential antimicrobial activity. Current study was designed ...

G. Rahimzadeh *, M. R. Fazeli , Amir Mozafari N. and M. Mesbahi

Department of Microbiology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).286-93

286-293

2091

748

35.

IN-VITRO CYTOTOXIC ACTIVITY OF LEAF EXTRACTS OF IPOMOEA JACQ. SPECIES AGAINST A 549AND HEP-G2CELL LINES

Members of the  genus Ipomoea of family Convolvulaceae besides being some of the most beautiful ornamental plants cultivated for their bell shaped flowers, are also of medicinal value, with some of them  reported as  cytotoxic agents against some cancer cell lines. The present study evaluates the anticancer activity of the leaf extracts of ten Ipomoea Jacq. Species growing in and around Mumbai,...

Vinaya A. Rane* and Behnaz B. Patel

Department of Botany, R. Ruia College, Matunga, Mumbai - 400 019, M.H., India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).294-99

294-299

2696

997

36.

AMNESIC POTENTIALITY OF DIAZEPAM AT LOW DOSE ON ADMINISTRATION VIA TRANSCRANIAL ROUTE IN RODENTS

The objective of study to evaluate a  drug Diazepam applied transcranially to brain targeted drug delivery to screening for its amnesic effects, in different learning and memory paradigms viz., rod walking test, locomotor activity test, elevated plus maze test, water maze test, pole climbing test and pole climbing test on trained animal. Diazepam 4mg/ kg intraperitoneal used as a standard for com...

Shibnath Kamila*, N. V. Satheesh Madhav and C. N. Sarkar

Bharat Institute of Technology Ibrahimpatnam, Mangalpally, RR. 500010, Telangana, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).300-07

300-307

1817

4784

37.

ANTI-DIABETIC EFFECTS OF ECLIPTA ALBA ON ALLOXAN-INDUCED DIABETIC MICE

The aim of the present study was to investigate the effects of Eclipta alba leaves extract on the biochemical parameters in alloxan induced diabetic Swiss albino mice. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 135 mg/kg body weight. Ethanolic extracts of E. alba leaves at dose of 200 mg/kg body weight were given orally in diabetic mice daily for fou...

Nivedita and Priyanka Vijay *

Research Associate, Division of Genetics, I.A.R.I., New Delhi

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).308-14

308-314

2001

739

38.

ETHNOPHARMACOBOTANICAL INFORMATIONS OF SOME HERBACEOUS MEDICINAL PLANTS USED BY TODA TRIBES OF THIASHOLA, MANJOOR, NILGIRIS, WESTERN GHATS, TAMILNADU, INDIA

The present paper highlights the therapeutic uses of herbaceous medicinal plants used for various ailments by Toda tribe living in the pockets of Western Ghats of Tamil Nadu are inhabitants of Thiashola, Manjoor, Nilgiri District. A total of 32 plant species belonging to 18 families used by them as herbal medicines to treat several common diseases such as Asthma,  antidote,  contraceptive and ni...

S. Sharmila*, K. Kalaichelvi and P. Abirami

PG and Research Department of Botany, Vellalar College for Women, Thindal, Erode - 638012, Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).315-20

315-320

2650

1178

39.

Cu (II) METAL COMPLEXES OF SCHIFF BASES, PREPARATION, CHARACTERISATION AND BIOLOGICAL ACTIVITY

Heterocyclic schiff bases of 2-amino-4, 6-dimethyl benzothiazole with selected heterocyclic α- hydroxy aldehyde and α-hydroxy ketones and their Cu (II) metal complexes have been synthesised. The Cu (II) metal complexes of schiff bases are reported and characterised based on elemental analysis, IR, 1H NMR, ESR, XRD, Thermal analysis, magnetic moment, and molar conductance. The molar conductance d...

V.G. Deshpande, Seema I Habib* and P.A. Kulkarni

P.G. Department of Chemistry and Organic Research Laboratory, Yeshwant Mahavidyalaya, Nanded -431602 Maharashtra, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).321-26

321-326

1778

773

40.

ECO-FRIENDLY AND COST-EFFECTIVE UV SPECTROSCOPY METHOD FOR THE ESTIMATION OF PREDNISOLONE SODIUM PHOSPHATE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Prednisolone Sodium Phosphate (PSP) is a steroidal anti-inflammatory or immune suppressive agent. It is a sodium salt of the phosphoester of the glucocorticoid prednisolone. It is freely soluble in water; soluble in methanol; slightly soluble in alcohol and in chloroform; and very slightly soluble in acetone and in dioxane.A simple spectrophotometric method was developed for the determination of ...

O. G. Bhusnure *, M. S. Bawage and S. B. Gholve

Channabasweshwar Pharmacy College, Department of Quality Assurance, Latur (M.S.), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).327-32

327-332

1558

1353

41.

A NOVEL SUSTAINED RELEASE ROBUST MATRIX PELLETS OF GLIPIZIDE

Multiparticulate drug delivery system are mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some amount desired characteristics such as pellets.The purpose of present study was to prepare sustained release robust matrix pellets of Glipizide. The study revealed successful application of factorial design, optimization of extrusion spheronization process, ...

P. K. Puranik, S. D. Pol *, S. B. Patil, N. G. Ransing, P. S. Ramteke, B. A. Patil, P. K. Khobragade and R. G. Palaskar.

Department of pharmaceutics, Government College of pharmacy, Aurangabad-431005, MH, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).333-44

333-344

1730

1037

42.

MORINDA PUBESCENS BARK EXTRACTS SHOWS ANTIMICROBIAL ACTIVITY

Morinda Pubescens belonging to the family rubiaceae has been reported to posses many medicinal properties according to indigenous system of medicine. The search for biologically active compounds from natural sources has always been of great interest to researchers looking for new drugs useful in infectious disease. In the present study, the various extracts of Morinda Pubescens bark was tested for...

Bharat Kumar Tyagi *, Rajesh Kumar Goyal and Pradeep Chauhan

Department of Pharmaceutical Chemistry, Institute of Professional Studies, College of Pharmacy, Shivpuri link road, Gwalior-474001, Madhya Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).345-48

345-348

2521

698

43.

NEW MICROBIAL SOURCES OF PUFA FROM THE ARABIAN SEA AND FRESH WATER HABITATS OF INDIAN TERRITORY

Polyunsaturated Fatty Acids (PUFA) have been shown to be of major importance in the prevention and treatment of a range of human diseases and disorders. A number of microorganisms have been shown to produce and accumulate PUFA. In the current study we have isolated 86 lipid producing microbes from various sources like a river from northern India, lakes from southern India and marine environments o...

A. A. K. Masurkar, A. G. Datar and B. V. Vakil

Guru Nanak Institute for Research and Development (G.N.I.R.D), GN Khalsa College, Matunga, Mumbai 400 019, Maharashtra, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).349-60

349-360

1966

910

44.

ACUTE TOXICITY STUDY OF ETHANOLIC EXTRACT OF SOLANUM LYCOPERSICUM (LEAF) IN SWISS ALBINO MICE

The Present Study was planned to assess the acute toxicity of Solanum lycopersicum Leaf. The study was designed according to the OECD guidelines as per that the dose level used as 5, 50, 300, 2000, 4000 mg/kg. Mice were orally administrated single dose of 200 and 400 mg/kg of ethanolic extract of Solanum lycopersicum. Physical, Biochemical, Hematological as well as histopathological parameters wer...

Priya Shukla * and Sunil Kumar

Department of Pharmacy, RITM College of Pharmacy, Lucknow-227202 (U.P.), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).361-66

361-366

2160

1098

45.

PREPARATION AND CHARACTERIZATION OF NANO-BIO HYBRID BASED MAGNETO LIPOSOME

The biological synthesis of magnetite nano-bio hybrid using plant extracts plays an important role in the field of nanotechnology. The present study demonstrates bio-reductive synthesis of protein coated magnetite (Fe3O4) nano-bio hybrid using leaf extracts of Datura inoxia plants and its encapsulation into liposome. Liposome is vesicles of varying size consisting of a spherical lipid bilayer and ...

Amlan Kumar Das*, Avinash Marwal and Ruchi Verma

Department of Nano Science and Technology, Faculty of Engineering and Technology (FET), Mody University of Science and Technology, Lakshmangarh, Sikar - 332311, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).367-75

367-375

2219

935

46.

CHARACTERIZATION AND CYTOTOXICITY EVALUATION OF SUPERPARAMAGNETIC NANOPARTICLES BIOSYNTHESIZED BY FUSARIUM OXYSPORUM SK

Superparamagnetic iron oxide nanoparticles have been used for various industrial and clinical applications. In the present study, biosynthesis of superparamagnetic Fe3O4 nanoparticles was carried out using a fungal isolate. The fungal isolate was identified as Fusarium oxysporum SK through 18S ribosomal DNA sequence analysis. The synthesized magnetic nanoparticles were subjected to Transmission El...

I. Arulpandi and S. Kanimozhi *

P. G. & Research Department of Microbiology, Asan Memorial College, Chennai – 600100, Tamilnadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).376-82

376-382

1621

650

47.

A STUDY ON PREVALENCE OF POLYCYSTIC OVARY SYNDROME AT A TERTIARY CARE HOSPITAL

The main objective of the study was to assess the prevalence of polycystic ovary syndrome at a tertiary care hospital. This study was a prospective observational study performed for a period of 6 months in infertility and gynecology clinic. For making a positive diagnosis of PCOS, all subjects were interviewed to furnish details of menstrual history including regularity, duration of cycles, and nu...

K. S .Lakshmi *, J. Jayasutha and Anjalakshi Chandrasekar

Professor &Dean SRM College of Pharmacy, SRM University, Kancheepuram, Tamilnadu - 603203, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).383-85

383-385

3996

1107

48.

TRANSMISSION & LEAKAGE MEASUREMENT OF NOVEL TELECOBALT MACHINE BHABHATRON-II

The Telecobalt machines are extensively used in developing countries due to its lesser cost, lesser power consumption and easy maintenance. The high activity source can be extensively used for at least 6-8 years due to its long half-life. Installing a Telecobalt unit comprises of fixing the machine in the treatment room, ensuring its mechanical motions, source loading and all other related Quality...

M. Athiyaman *, Hemalatha Athiyaman, R. Rajasekaran and R. Neelakandan

Department of Radiological Physics, Acharya Tulsi Regional Cancer Center, S.P. Medical College and A.G. Hospitals, Bikaner, Rajasthan, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).386-92

386-392

3025

992

49.

QUALITATIVE AND QUANTITATIVE PHYTOCHEMICAL SCREENING OF DIFFERENT PLANT PARTS OF PHYLLANTHUS AMARUS SCHUM. & THONN. COLLECTED FROM CENTRAL INDIA WITH RESPECT TO THE TRADITIONAL CLAIMS FOR THEIR MEDICINAL USES

Phyllanthus amarus Schum. and Thonn. is one of the highly used medicinal plants both traditionally and scientifically. Phytochemical screening is of high importance to establish the claims of medicinal uses by traditional and folk medicine practitioners. Since, environmental, climatic and soil conditions have strong effect on production and level of particular phytochemicals in a given plant part,...

Aparna Awasthi , Ranu Singh and Manish K. Agrawal *

Excellent Bio Research Solutions Pvt. Ltd., 1370, Napier Town, Jabalpur - 48200,1 India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).393-98

393-398

5134

1255

50.

SEASONAL COMPARATIVE STUDY OF KANOI PAPER MILL EFFLUENT IN REFERENCE OF PHYSICO-CHEMICAL AND HEAVY METALS

In order to ascertain the degree of various pollutants in Kanoi Paper mill effluent of Bilaspur district (C.G.) India. We have taken minor research project. For attained to this purpose, we have selected eight sampling sites; Four SW and four GW sources. Collected samples (Premonsoon, Monsoon and Postmonsoon 2012) were analyzed for physico-chemical special chloride and phenolic compounds and heavy...

M. M. Vaishnav , Milan Hait * and Priya Priy Darsani

Research Scholar, Department of Chemistry, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G.-495113, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).399-04

399-404

1740

651

51.

STUDIES ON EFFECT OF BREWERY WASTE WATER SLUDGE (BWS) ON MORPHOLOGY AND YIELD OF CHILLY (CAPSICUM ANNUM L.) PLANT.

In an effort to increase yields from a limited area, farmers tend to indiscriminately use more chemical fertilizers and pesticides. The brewery sludge can be directly applied to the soil for the agricultural purposes or it can be composted before utilizing for plant growth. The main objective of the present study is to test the efficacy of the bio-fertilizer in the growth and yield of Chilly Plant...

N. Ramya *, T. Srinivas and K. Aruna Lakshmi

Deptartment of Environmental Studies. GITAM Institute of Science, GITAM University, Vishakhapatnam, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).405-09

405-409

2424

895

52.

A VALIDATED REPORT ON FORMULATION STABILITY STUDIES OF BENDAMUSTINE HYDROCHLORIDE

The objective of this study was to adopt the analytical method. This adoption procedure was carried out by validating the method parameters and conducting the forced degradation studies to check the interference of the chromatographic response of the degradation products with the drug. In the present study an attempt was made to studies related to system suitability, linearity, accuracy, precision...

Niharika Sridasam*, Ravinder Reddy Y. and V. Kavya

Teegala Ram Reddy College Of Pharmacy, #4-202, Meerpet, Saroor Nagar (M), Ranga Reddy (Dist), Hyderabad-500079, Telangana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).410-20

410-420

2910

0

53.

ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF THIAZOLIDINEDIONE DERIVATIVES

The main aim of the present study was to synthesize new leads with potential antibacterial and antioxidant activities. As a part of systematic investigation of synthesis and biological activity, some of the new thiazoldinedione compounds 5a-e were prepared and screened for their antibacterial and antioxidant activities. The antibacterial evaluation of newly synthesized compounds was carried out by...

S. Rekha * and S. Chandrashekhara

Lecturer, Dept. of Pharmaceutical chemistry, T. John College of Pharmacy # 88/1 Gottegere Post Bannerghatta main Road Bangalore -560083, Karnataka. India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).421-28

421-428

1944

736

54.

SYNTHESIS, SPECTRAL CHARACTERIZATION AND PHARMACEUTICAL IMPORTANCE OF NOVEL 4H-1, 4-BENZOTHIAZINES, AND THEIR SULFONE ANALOGUES

In recent years, synthesis and biological evaluation of novel 4H-1, 4-benzothiazines and their sulfone analogues have gained momentum due to their medicinal and industrial importance. The present article describes the synthesis of new 4H-1, 4-benzothiazines via condensation and oxidative cyclization of substituted 2-aminobenzenethiols with compounds containing active methylene groups. It is believ...

N. Gautam , A. Garg * and D. C. Gautam

Research Scholar, A-232, Behind National Handloom, Vaishali Nagar, Jaipur – 302021, Rajasthan, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).429-36

429-436

1575

784

55.

VISIBLE SPECTROSCOPIC DETERMINATION OF FAROPENEM SODIUM IN PHARMACEUTICAL DOSAGE FORM

Two simple, precise, accurate and economical visible spectrophotometric methods were developed for the determination of faropenem in bulk and in tablet dosage forms have been described. The method A was based on the formation of green color complex with Potassium ferri-cyanide in the presence of Ferric chloride, which show maximum absorbance (λ max) at 745nm.The method B is based on the reduction...

Iffath Rizwana , K. Vanitha Prakash *, G. Krishna Mohan

Professor and Principal, SSJ College of Pharmacy, Vattinagula Pally, Gandipet, Hyderabad -500075, Rangareddy Dist. A.P. India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).437-41

437-441

1918

925

56.

FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF LOPINAVIR LOADED SOLID LIPID NANOPARTICLES

Lopinavir (LPV) is potent and poorly bioavailable molecule which is frequently administered protease inhibitors in the treatment of the HIV. Solid Lipid Nanoparticles (SLNs) of LPV were prepared using High Speed Homogenization. LPV were successfully encapsulated in the mixture of Glyceryl Behenate and Glyceryl monostearate. Poloxamer 188 was used as a surfactant for the preparation of the SLNs. Fo...

Kaushal P. Patel*, Chirayu J. Pathak and Rakesh P. Patel

Department of Pharmaceutics & Pharmaceutical Technology, S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva - 384012, Mehsana, Gujarat, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).442-52

442-452

2649

869

57.

EFFICACY OF MUNZIJ WA MUSHIL-E-BALGHAM (POLY HERBAL FORMULATIONS) AND MASSAGE WITH ROGHAN-E-MALKANGANI IN FALIJ NISFI (HEMIPLEGIA): A RANDOMISED CONTROLLED CLINICAL TRIAL

This study was conducted as a single blind, randomized and standard controlled clinical trial in cases of Falij Nisfi (Hemiplegia) due to ischaemic stroke. Forty eligible patients of Hemiplegia were randomized into test and control groups, comprising 20 patients in each.  Test group was given Nuskha munzije balghamfor12 days, followed byNuskha Mushile Balgham, mixed with Munzije Balgham for next ...

Abdal Ahmed , Abdul Nasir Ansari , S. Javed Ali * and Mohd Yasir

Room No.16 Unit II Boys Hostel NIUM CAMPUS, Bangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).453-58

453-458

3816

1065

58.

A CONVENIENT SYNTHESIS AND BIOCIDAL ACTIVITY OF (N-ALKYL/ARYL SULPHONAMIDO)-4H-BENZ [d] OXAZIN-2-ONE DERIVATIVES

Compounds with a 2(H)-1, 4-benzoxazin-3(4H)-one skeleton have attached the attention of phytochemistry researchers since 2, 4-dihydroxy-(2H)-1,4-benzoxazin-3(4H) and 2,4-dihydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one were isolated from plants belonging to the Poaceae family. These compounds exihibit interesting properties11 such as phytotoxic, antimicrobial12, antifeedent, antifungal and insect...

Manoj Kumar Srivastava* and Anamika Pandey

Department of Chemistry, M.G. Post Graduate College, Gorakhpur-273001 (U.P.), India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).459-62

459-462

1869

634

59.

MOLECULAR DOCKING OF PHYTOCHEMICAL AS FTSZ CELL DIVISION PROTEIN INHIBITOR IN MYCOBACTERIUM TUBERCULOSIS

Mycobacterium tuberculosis is the causal agent of tuberculosis which is an infectious disease responsible for more than 2 million deaths per annum worldwide, mainly in developing countries. Cell division of this microbe is very crucial for propagation. Filamenting temperature sensitive mutant Z (FtsZ) is very important player that seems to assemble into a dynamic ring (Z- ring) on the inner surfac...

Dhrubajyoti Das*, Maina Borah, Anil Kumar Singh, Robin Das and Hari Prasana Deka Boruah*

Biotechnology, CSIR-North East Institute of Science & Technology, Jorhat-785006, Assam, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).463-72

463-472

2608

1150

60.

ANTI-OXIDANT ACTIVITY OF SELECTED MEDICINAL PLANTS OF THE HIMALAYAN REGION

Natural medicines and nutraceuticals are good sources of anti-oxidant and are gaining popularity for their capacity to enhance, health-protective effects. The aim of the present study was to investigate the anti-oxidant activity of some natural medicine from the Himalayan region of   Nepal. Carefully collected plant materials were subjected to maceration with methanol for about 48 hours. Anti-ox...

Ravin Bhandari*, Grishma Sharma and Nirmala Jamarkatel-pandit

School of Health and Allied Science, Department of Pharmaceutical Science, Pokhara University Nepal.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).473-77

473-477

1988

773

61.

NOVEL PROPENYL FLAVONOIDS GLYCOSIDE AND ANTIOXIDANT ACTIVITY OF EGYPTIAN BAUHINIA RETUSA

Column chromatography of ethyl acetate of Bauhinia retusa afforded a novel flavonoid identified as [ rhamnetin-3-O-α- L-rhamnopyranosyl-3’-O-(prop-1-enyl)], in addition to kaempferol, isorhamnetin-3-α-rhamnoside, qurcitrin, quercetin  3-O-β-D-glucopyranosyl-β-D-glucopyranoside, and quercetin 3,7-di-o- β-D-glucoside  have been isolated for the first time. Their structures were established ...

Zeinab I.A. El Sayed, Wafaa H. B. Hassan and Abdel-Monem Ateya

Department of Pharmacogonosy, Faculty of Pharmacy, University of Zagazig, Zagazig, B.O Box 44519, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).478-84

478-484

1675

655

62.

EFFECT OF HYDRO-ALCOHOLIC ROOT EXTRACT OF PLUMBAGO ZEYLANICA L ALONE AND ITS COMBINATION WITH AQUEOUS LEAF EXTRACT OF CAMELLIA SINENSIS ON RESERPINE INDUCED PARKINSONISM

Aim: To investigate the antiparkinsonism activity of hydro alcoholic root extract of P. zeylanica L (PZE) alone and its combination with aqueous extract of C. sinensis leaves (AECS) in reserpine induced model. Materials and methods: Parkinsonism (PD) was induced by sub cutaneous administration of reserpine (1 mg/kg) for 5 days. The extracts/drugs being tested were administered orally (p.o) 60 min ...

Sibi P. Ittiyavirah* and R. Ruby

Division of Pharmacology, Department of Pharmaceutical Sciences, Mahatma Gandhi University, Cheruvandoor campus, Ettumanoor P.O., Kottayam, Kerala, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).485-90

485-490

1800

720

63.

ISOLATION, PURIFICATION AND STRUCTURAL ELUCIDATION OF FLAVONOIDS FROM METHANOL EXTRACT OF ARIEL PARTS OF DERRIS BREVIPES (BENTH.) BAKER.

Two flavonoids were isolated by performing column chromatographic separation of methanol extract of ariel parts of Derris brevipes (Benth) Baker. Structural elucidation of purified compounds was done on the basis of spectral analysis using IR, 1H NMR, 13C NMR 2D NMR spectroscopy and Mass spectrometry. The structures of the flavonoids were elucidated as 2’, 4’-dihydroxy-4-methoxy-3’-prenylcha...

R. S.Telekone * and M. Khan

Padm. Dr. D.Y. Patil college of Pharmacy. D.Y.Patil Educational complex, Akurdi, Pune 411044, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).491-01

491-501

2090

846