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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 6 (2015) - Issue 3, March

Review Articles

 
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1.

APOPTOSIS: BASIC CONCEPTS, MECHANISMS AND CLINICAL IMPLICATIONS

Apoptosis, a well choreographed gene-directed cellular destruction, plays an important role in a variety of biological events, including morphogenesis, homeostatic maintenance of various tissues and removal of harmful cells while dysregulated apoptosis has been implicated in a variety of disease such as cancer, systemic and organ specific autoimmune disease and neurodegenerative disorders. Apoptos...

Bibhas Kar and S. Sivamani

Centre for Genetic Studies & Research, The Madras Medical Mission, Chennai-600037,TN, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).940-50

940-950

3119

1371

2.

NASAL DRUG DELIVERY- AN OVERVIEW

Over the past few decades the nasal route has gained widespread interest as a promising and an alternative route to oral and parenteral drug delivery. The nasal mucosa being highly vascularized and permeable provides a rapid onset of therapeutic action. It is a convenient, compliant and needleless mode of drug delivery suitable for the treatment of both acute and chronic diseases. In addition, nas...

Jyoti Mundlia , Mukesh Kumar and Amardeep

Assistant Professor College of Pharmacy , PGIMS, Rohtak, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).951-60

951-960

2958

1114

3.

A REVIEW ON NANOTIZED HERBAL DRUGS

A budding interest in Nanopharmaceuticals had generated a number of advancements throughout recent years with a focus on engineering novel applications. Nanophytomedicines are prepared from active phytoconstituents or standardized extracts. The world market for nanomedicine is estimated to reach $130.9 billion by the fiscal year 2016. Liposome nanoparticle (NP) with entrapped doxorubicin was repor...

Anupam Kumar Sachan* and Ankita Gupta

Dayanand Dinanath College, Institute of Pharmacy, Kanpur, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).961-70

961-970

3914

2734

4.

MEDICINAL SIGNIFICANCE OF LOVASTATIN

Lovastatin is a naturally occurring drug of statin family used for lowering cholesterol. It is found that it can be useful for treatment or management of multiple diseases and has immense medicinal significance. On one side, this drug is used to induce apoptosis in various cancer cells, while other reports indicate that it also promotes cell survival to alleviate certain disease conditions. Antivi...

N. Wajid *, S. S. Anwar, F. Ali, M. Zahoor, N. Hamid, M. M. Aslam and A. Ali

Institute of Molecular Biology and Biotechnology, The University of Lahore , Lahore, Pakistan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).971-77

971-977

3320

1229

5.

β-LACTAMS: A MINI REVIEW OF THEIR BIOLOGICAL ACTIVITY

Synthesis of heterocylic compound has always drawn the attention of chemist over the years mainly because of their important biological properties. Particularly, the role of β–lactam which are endowed with unique structure and potent biological activity. The β-lactam heterocycles are considered as an important contribution of science to humanity since they have been constituents of living orga...

Apoorva Gupta* and A. K. Halve

School of Studies in Chemistry, Jiwaji University, Gwalior (M. P.), 474011, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).978-87

978-987

3443

1407

6.

ANTIFERTILITY ACTIVITY OF MEDICINAL PLANTS ON MALE AND FEMALE REPRODUCTION

Population control is a significant issue worldwide especially in developing countries like India. Population breakout has responsible for various deleterious effects on life surviving resources on the earth. Therefore fertility regulation is necessary for the conservation of life supporting resources as well as good reproductive life of both males and females. Various chemical methods of cont...

Parveena Devi , Pradeep Kumar , Nidhi and Isha Dhamija*

P. D. M. College of Pharmacy , Bahadurgarh, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).988-01

988-1001

5775

2581

Research Articles

 
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7.

CONVOLUTION STUDY AND THE ALCOHOLIC BEVERAGE EFFECT ON LANSOPRAZOLE DELAYED-RELEASE CAPSULES AND APPLICATION OF SIMILARITY FACTOR TO TWO-STAGE IN – VITRO DISSOLUTION PARADIGM

Lansoprazole, a proton pump inhibitor, is used to treat ulcers in the stomach and duodenum. In order to protect this acid labile drug from being degraded in the gastric medium, the marketed oral dosage forms are formulated into delayed release pellets and tablets. The aims of this research were (1) to investigate the principal site of drug release and absorption rate between an over-the-counter (O...

Monica C. Chuong *, Helal Alsulimani, Saheed Alabi, Nawaf Al-Saif, Sukran Damgali, Serkan Killioglu, Steven La, Parth Patel, Dev Prasad, Jie Tan, Anand Ubhe, Jarred Uy, Michael Valladares, Loan Vo, Mayura Wagle, Steven Crosby and Ahmed Mehanna

Department of Pharmaceutical Sciences, MCPHS University, Boston, MA, USA

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1002-12

1002-1012

2443

1630

8.

BIOLOGICALLY ACTIVE COMPOUNDS FROM LEUCAS LAVANDULAEFOLIA

The investigation of terrestrial plants origin aimed at searching new natural biologically active compounds is a central issue of this kind of studies, through structure elucidation combined with biological tests. We investigated the biologically active secondary metabolites from Leucas lavandulaefolia towards various effects on the behavior of Aphanomyces cochlioides zoospores and with antimicrob...

Parvin Begum *, Yanqing Wang and Bunshi Fugetsu

Laboratory of Environmental Medical Chemistry, Graduate School of Environmental Science, Hokkaido University, Sapporo 060-0810, Japan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1013-21

1013-1021

2537

1266

9.

INTERACTION OF TETRACYCLINE HYDROCHLORIDE WITH IRON: KINETIC SPECTROPHOTOMETRIC AND CONDUCTOMETRIC INVESTIGATIONS

The interaction of the antibiotic, tetracycline hydrochloride (TC.HCl) has been investigated employing three simple spectrophotometric and conductometric methods. In methods (A and B), a kinetic spectrophotometric procedure based on the oxidation of (TC.HCl) by Fe3+ ion in the presence of 1, 10 - Phenanthroline (o-phen) (A) and 2, 2′- Bipyridyl (bipy) (B) was developed. The formation of the ferr...

Marwa S. Elazazy *

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

DOI: http://dx.doi.org/ 10.13040/IJPSR.0975-8232.6(3).1022-32

1022-1032

2209

745

10.

HALOGENATED TRIAZINEDIONES BEHAVE AS ANTAGONISTS OF PKR1: IN VITRO AND IN VIVO PHARMACOLOGICAL CHARACTERIZATION

Different prokineticin receptor antagonists, based on the triazinedione scaffold, were synthesized by a new efficient method. Here we demonstrated that 5-benzyltriazinediones substituted in position para of the benzyl group with halogens provide compounds endowed with interesting selectivity for the Prokineticin receptor 1 (PKR1). BRET technology indicates that such substitution results in increas...

R Lattanzi , C Congiu , V Onnis , A Deplano , S Salvadori , V Marconi , D Maftei , A Francioso , C Ambrosio , I Casella ,T Costa , G Caltabiano , M T Matsoukas , G Balboni and L Negri *

Department of Physiology and Pharmacology ,Sapienza University of Rome, Rome, Italy

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1033-42

1033-1042

1858

631

11.

HISTOLOGICAL STUDY OF THE EFFECT OF MALATHION ON LIVER AND KIDNEY TISSUES OF MICE MODEL

Malathion is a widely used organophosphorous pesticide that a large number of populations are undesirably exposing themselves to severe health risk due to taking up the contaminated foods, water and vegetables containing malathion. The present study was carried out through histopathologic test to evaluate the extent of damage caused by malathion in the liver and kidney tissues of mice. Twenty five...

M. A. A. Mamun , A. Rahman , S.H. Belal , M. A. Islam , M. E. H. Sarker , M. S. I. Arman , A. E. Ekram and K.M.F. Hoque *

Protein Science Lab , Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi , Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1043-48

1043-1048

3188

936

12.

IN – VIVO CONFIRMATION OF A 49.6 KDA PROTEIN PILI OF HELICOBACTER PYLORI TO PREVENT DESTRUCTION OF GASTRIC CELLS AGAINST LIVE HOMOLOGOUS BACTERIA IN MICE

Peptic ulcers is one of the major gastrointestinal disorder in human being that generally associated with the infection of Helicobacter pylori, a gram-negative microaerophilic bacterium in stomach. It is also linked to the development of the stomach cancer. The aim of this study was  to investigate the in vivo properties of the sub-unit pili proteins with molecular weight of about  49,6 kDa in m...

Hamong Suharsono , Sumarno Reto Prawiro *, I Nyoman Mantik and Made Agus Hendrayana

Laboratory of Microbiology, Medical Faculty of Brawijaya University Malang, Indonesia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1049-53

1049-105

1679

588

13.

INHIBITION OF ANGIOTENSIN CONVERTING ENZYME (ACE) ACTIVITY BY SOME INDONESIA EDIBLE PLANTS

Antihypertensive properties of plant can be evaluated by in vitro method on inhibition of Angiotensin Converting Enzyme (ACE) activity. In this research, we investigate the inhibitory effect of several common edible plants on blocking ACE activity. ACE activity was evaluated by using N-hippuryl-L-histidyl-L-leucine (HHL) as substrate and the inhibitory effect of extracts were determined based on t...

F. C. Saputri *, A. Mun’im , D. Lukmanto, S. N. Aisyah and J. S. Rinandy

Pharmacology Laboratory, Faculty of Pharmacy, University of Indonesia, Kampus UI Depok-West Java , Indonesia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1054-59

1054-1059

2776

1268

14.

DESIGN, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL 1-(2-(4-FLUORO BENZYLTHIO)PYRIMIDIN-4-YL-AMINO)-4-(SUBSTITUTED PHENYL)AZETIDIN-2-ONES

A series of novel 1-(2-(4-fluorobenzylthio)pyrimidin-4-yl-amino)-4-(substituted phenyl)azetidin-2-one analogues (3a-e) were synthesized starting from 2-thiouracil. Reaction of 2-thiouracil with 4-fluorobenzylchloride gave 2-(4-fluorobenzylthio) pyrimidin-4(3H)-one which on chlorination with POCl3 yielded 2-(4-fluorobenzylthio)-4-chloropyrimidine. Further reaction of compound 2-(4-fluorobenzylthio)...

N. M. Goudgaon* and Y. Rohini Reddy

Department of Post Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga - 585 106, Karnataka, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1060-65

1060-1065

1473

510

15.

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF GLIMEPIRIDE AND EZETIMIBE IN BULK AND TABLET DOSAGE FORM

A simple, rapid, sensitive, precise, accurate and economic isocratic stability indicating RP-HPLC chromatographic method was developed and validated for the simultaneous estimation of Glimepiride and Ezetimibe in bulk and tablet dosage form. The method was developed through a Hypersil ODS C18 (150mm x 4.6 mm, 5m) column, mobile phase comprised of phosphate in water as buffer PH adjusted to 4.8 wit...

P. Pavani, A. Srilekha and B. Sreedhar*

Inorganic and Physical Chemistry Division, Council of Scientific and Industrial Research - Indian Institute of Chemical Technology, Hyderabad 500607, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1066-77

1066-1077

1900

740

16.

AN EVALUATION OF THE ANTIOXIDANT PROPERTIES OF SOME OIL YIELDING LAMIACEOUS PLANTS FROM MORNI HILLS (HARYANA, INDIA)

The present study was conducted to explore the antioxidant and radical scavenging activities of essential oil extracted from the leaves of plants of family Lamiaceae from Morni hills in the north-eastern part of the state of Haryana, India. Ten plants- Hyptis suaveolens, Mentha longifolia, M. pulegium, Ocimum basilicum, Plectranthus incanus, P. striatus, Pogostemon benghalensis, Rabdosia rugosa, S...

Sartaj Singh , Daizy Rani Batish, Ravinder Kuamr Kohli and Harminder Pal Singh

Department of Botany, Panjab University, Chandigarh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1078-82

1078-1082

1887

838

17.

COMMUNITY DRUG RETAIL OUTLET SERVICES IN HARAR TOWN, EASTERN ETHIOPIA

Background: The main activities of community pharmacists are processing of prescriptions, care of patients or clinical pharmacy, monitoring of drug utilization, extemporaneous preparation and small scale manufacture of medicines, responding to symptoms of minor ailments, informing health care professionals and the public, and health promotion. Objectives: To assess community drug retail outlets se...

Rehima Shemsedin and Bereket Molla Tigabu *

School of Pharmacy, Clinical Pharmacy Unit, Haramaya University, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1083-90

1083-1090

1761

507

18.

FORMULATION DEVELOPMENT OF LYOPHILIZED FLOATING BEADS CONTAINING GINGER EXTRACT AND NIGELLA SATIVA OIL

Lyophillized  floating  beads  have  been  investigated  as  a  possible  gastro-retentive  dosage  forms containing Ginger (Zingiber Officinalis) extract ( ZOE) and Nigella Sativa oil (NSO).  Emulsion gelation  method  was  used  in  preparation  of  ZOE-NSO  entrapped  floating  alginate  beads.  Drug content and floating properties of the beads were found to be satisfact...

Munira M Momin *, Aditee Mishal and Tejaswi Kale

SVKM’S Dr. Bhanuben Nanavati College of Pharmacy, Mithibai Campus, Ville Parle (w), Mumbai, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1091-96

1091-1096

2092

681

19.

SIMULTANEOUS ESTIMATION OF SULFAQUINOXALINE SODIUM AND AMPROLIUM HYDROCHLORIDE BY RP- HPLC.

A new RP-HPLC method was developed and validated for the simultaneous determination of amprolium hydrochloride and sulfaquinoxaline sodium in a powder dosage form. The chromatographic separation was  achieved by isocratic mode with Phosphate buffer  and Acetonitrile (30:70; v/v), as mobile phase and using C-18 RP-Amide (25.0cm × 4.6 mmi.d, 5µ particle size) as stationary phase, with a flow rat...

Abhilekha P Mantri*, Rubeena Mubeen S, Nischal Kandepu and Shiva Kumar

Provimi Animal Nutrition India Pvt Ltd, C7/22, KSSIDC Industrial Area, Yelahanka Newtown, Bangalore- 560 064, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1097-00

1097-1100

2310

1280

20.

STUDY ON PRELIMINARY PHYTOCHEMICAL AND ANTIBACTERIAL ACTIVITY AGAINST HUMAN PATHOGENS OF AN ENDANGERED ORCHID-HABENARIA PLANTAGINEA LINDL

Habenaria plantaginea Lindl. (Orchidaceae) is used as a medicinal plant in several countries. In this study, ethanol, chloroform and water extracts of Habenaria plantaginea were evaluated for antibacterial activity against bacterial (MTCC) strains. Antibacterial activity of this plants extracts were performed using agar disc diffusion method. The antibacterial activity of ethanol extracts showed m...

M. Keerthiga * and S. P. Anand

Department of Biotechnology, Department of Botany, National College (Autonomous), Tiruchirappalli, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1101-06

1101-06

1390

869

21.

ANTIMICROBIAL PROPERTIES OF DIFFERENT SOLVENTS EXTRACT OF RUMEX VESICARIUS LINN. ON SOME SELECTED BACTERIAL AND FUNGAL ISOLATES

The Antimicrobial (antifungal and antibacterial) properties of the different solvents extracts (benzene, pet ether, acetone, chloroform, methanol and aqueous) of Rumex vesicarius Linn plant plants, on four bacterial (Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) and four fungal isolates (Aspergillus niger, Tricoderma reesei, Penicillium funiculosum and Fusa...

Ankita Shah*, Parul Sharma and Rekha Vijayvergia

Plant Pathology and Plant Biochemistry Laboratory, Department of Botany, University of Rajasthan, Jaipur-302004, India.

DOI: 10.13040/IJPSR.0975-8232.6(3).1107-14

1107-1114

1619

606

22.

NEURO-PROTECTIVE PROPERTIES OF ORTHOSIPHON STAMINUS (BENTH) LEAF METHANOLIC FRACTION THROUGH ANTIOXIDANT MECHANISMS ON SH-SY5Y CELLS: AN IN-VITRO EVALUATION

In present study to evaluate the mechanisms behind the antioxidant and neuro-protective potential of Orthosiphon staminus methanol bio active guided fraction (OMF) using SH-SY5Y human neuroblastoma cell culture model was carried out. In in-vitro studies, mechanisms of neutralization of H2O2 induced toxicity by OMF using MTT, LDH, ROS, MMP, MDA, Comet assay was performed. Regulation of anti-oxidant...

N. Vijaya Sree *, P. Udaya Sri and N. Ramarao

Department of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(3).1115-25

1115-1125

1738

769

23.

FORMULATION DEVELOPMENT AND PHARMACOTECHNICAL EVALUATION OF MUCOADHESIVE DRUG DELIVERY SYSTEM FOR ORAL CANDIDIASIS

Itraconazole is an anti-fungal drug.  It prevents growth of several types of fungi by preventing the fungi from producing the membranes that surround the fungal cells. It is active against fungal infections such as aspergillosis, blastomycosis, histoplasmosis, and candidiasis, as well as fungal infection localized to the toenails and fingernails (onychomycosis). The oral liquid is typically used ...

S. K. Kar *, Munira Momin, Sonali Joshi, Chaitrali Kute and Aarti Jaybhaye

Oriental College of Pharmacy, Sector-2, Sanpada, Navi Mumbai-400705, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(3).1126-31

1126-1131

1867

538

24.

CELLULOSE AS SOLE SUBSTRATE FOR BIO ETHANOL PRODUCTION: DEVELOPMENT OF STRUCTURAL MOLECULAR MODEL OF ENDOGLUCANASE III FROM TRICHODERMA REESEI USING BIOINFORMATIC TOOLS

One of our greatest challenges in improving nation’s economy is to reduce the dependence on imported petroleum products. To accomplish this, we need a variety of alternative fuels, which includes ethanol produced from cellulosic materials. Cellulose is a rich natural biopolymer on earth and most dominating agricultural waste. Apart from the fossil fuels, bioethanol is used as chief renewable ene...

B. Chandrasekhar and B. Bhima*

Department of Microbiology, University College of Science, Osmania University, Hyderabad, India

DOI: 10.13040/IJPSR.0975-8232.6(3).1132-36

1132-1136

1573

718

25.

INFUSION OF ADRENOMEDULLIN-2 ANTAGONIST INDUCES APOPTOSIS AND CHANGES m-RNA EXPRESSION LEVELS OF ADM2 RECEPTORS IN PLACENTA OF PREGNANT RATS DURING LATE GESTATION AND CAUSES FETOPLACENTAL GROWTH RESTRICTION

Adrenomedullin-2 or Intermedin (ADM2/IMD) is newly identified novel hormone belongs to peptide family like AM, calcitonin, CGRP, amylin and it is widely distributed in various tissues including ovaries, uterus & placenta. The aim of present study was to investigate the role endogenous ADM2 in fetoplacental development in pregnant rats during late gestation period through infusion of ADM2 antag...

G. Lakshmi Deepika and Penchalaneni Josthna*

Department of Biotechnology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati 517502, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(3).1137-49

1137-1149

1388

715

26.

ANTIOXIDANT AND ANTIARTHRITIC ACTIVITY OF ALLICIN IN ANIMAL MODELS

Inflammation is common and essential protective response to the harmful stimuli such as infectious agents, antigen-antibody reactions, thermal, chemical, and physical agents, and ischemia. The oxidative stress is produced by free radicals, predominately reactive oxygen species (ROS), which cause tissue damage from oxidative stress. Antioxidants play an important role in neutralizing such free radi...

M. K. Jayanthi *, Sushma Naidu V., Pramod and Sunil

Department of Pharmacology, JSS Medical College, JSS University JSS Nagar, Mysore-570015, India

DOI: 10.13040/IJPSR.0975-8232.6(3).1150-55

1150-1155

1873

694

28.

OPTIMIZATION OF CAROTENOIDS PRODUCTION BY RHODOTORULA MUCILAGINOSA

Optimization of total carotenoids production is dependent on various cultural and physical parameters for pigmented yeasts. The carotenoid production of the red yeast Rhodotorula mucilaginosa MTCC11835 was optimized using response surface methodology. The carotenogenesis in yeasts is known to be affected by different nutritional factors and environmental stress factors. Effect of various growth pa...

M. K. Dhaliwal* and N. Chandra

Department of Microbiology , Birla College, Kalyan, (M.S.), India

DOI: 10.13040/IJPSR.0975-8232.6(3).1161-65

1161-1165

1620

1096

29.

ZINC OXIDE NANOPARTICLES INDUCED HAEMOLYTIC CYTOTOXICITY IN HORSE RED BLOOD CELLS

Metal oxide in the nanorange acquires distinctive properties that depend on size, chemical composition and surface chemistry. Among the metal oxide nanoparticles, the zinc oxide nanoparticles (ZnO NPs) are commonly used for their antimicrobial properties. ZnO nanomaterials are incorporated into a variety of skin coatings because of their antimicrobial and/or antifungal properties. Most of the futu...

R Raguvaran, Anju Manuja*, Sandeep Singh, Meenu Chopra , Balvinder K. Manuja and U. Dimri

National Research Centre on Equines, Sirsa road, Hisar, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.6(3).1166-69

1166-1169

2037

668

30.

CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS DETERMINATION OF SIMVASTATIN AND SITAGLIPTIN IN COMBINED DOSAGE FORM

To develop and validate simple and precise methods RP – HPLC (Method A) and Dual wavelength method (Method B) for simultaneous estimation of Simvastatin (SIM) and Sitagliptin (SITA) in combined dosage form. Methods used are Method A, the chromatographic separation was achieved by using mobile phase acetonitrile: methanol: water (50:30:20), a C18 column. The mobile phase was pumped at a flow rate...

D. Phaneemdra * and G. Nagamalleswari

Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-522034, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.6(3).1170-75

1170-1175

1682

607

31.

PHYTOCHEMICAL SCREENING, ANTIMICROBIAL PROPERTIES AND ESSENTIAL OIL CONSTITUENTS OF COMBRETUM SORDIDUM EXELL

Plants in Combretaceae family are traditionally reputed to be anthelmintics and antimicrobial agents. Dried aerial parts of Combretum sordidum (Exell) were ground to fine powder and extracted using ethanol. Ethanol extract was partitioned to obtain hexane and ethylacetate extracts successively. These extracts were screened for secondary metabolites using standard methods and evaluated for their an...

O. O. Olaoluwa* and F. Ogunbor

Department of Chemistry, Faculty of Science, University of Ibadan, 200284, Ibadan, Oyo state, Nigeria

DOI: 10.13040/IJPSR.0975-8232.6(3).1176-80

1176-1180

1970

881

32.

IN-VITRO CYOTOTOXIC STUDIES OF CAESALPINIA BONDUCELLA F. USING AQUEOUS EXTRACT OF SEED POWDER AND CALLUS

In the traditional system of Indian medicine Caesalpinia bonducella Flem. is widely used for its medicinal properties. All parts are valuable as it contains various secondary metabolites. Seeds contain 20-30% of oil. On the basis of phyto-chemical analysis of the seed it is known to contain alkaloids, flavonoids, glycosides, saponins and furano di terpenes. The plant possesses antidiabetic, antiox...

Shirsat Rajani Kamerkar Urwashi and Rai Aruna *

Department of Botany, Smt. C.H.M. College (Affiliated to University of Mumbai), Ulhasnagar, Thane, Maharashtra.

DOI: 10.13040/IJPSR.0975-8232.6(3).1181-83

1181-1183

1889

684

33.

CHOLESTEROL LOWERING PROPERTY OF LACTOBACILLUS PLANTARUM ISOLATED FROM COW MILK

The aim of this study is to investigate the cholesterol lowering property of bacterial isolates. Different cultures of the bacteria were isolated from cow milk. Out of the cultured bacterial isolates Lactobacillus species, Micrococcus luteus and Staphylococcus aureus were screened. Three isolates such as Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus casei were identified based on...

K. Amutha* and V. Kokila

Department of Biotechnology, Vels University, Pallavaram, Chennai, India

DOI: 10.13040/IJPSR.0975-8232.6(3).1184-89

1184-1189

2176

702

34.

OPTIMIZATION OF ANTIFUNGAL COMPOUND PRODUCTION BY A MODERATELY HALOPHILIC STREPTOMYCES WERRAENSIS HB-11

A moderately halophilic strain of actinomycete HB-11, having ability to produce antifungal compound was isolated from soil samples collected from the region of Mumbai sea port, India. The strain HB-11 was identified as Streptomyces werraensis on the basis of its morphological characteristics and 16S rRNA gene sequencing. It is found to be active against both filamentous as well as yeast fungi incl...

H.J. Bhosale *, T. A. Kadam, S.G. Fulwad, M.A. Karale and O.S. Kanse

School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1190-99

1190-1199

2082

745

35.

FORMULATION, EVALUATION AND ESTIMATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE CONVENTIONAL TABLETS IN COMBINED DOSAGE FORM AND ITS COMPARISON WITH MARKETED FORMULATIONS

Oral route of drug administration have wide acceptance up to 50-60% of total dosage forms. Solid dosage forms are popular because of ease of administration, accurate dosage, self-medication, pain avoidance and most importantly the patient compliance. This study was aimed at development of Propranolol hydrochloride and flunarizine dihydrochloride conventional dissolving tablets in combined dosage f...

Dipali Malhotra* and Ravi Sharma

Department of Pharmaceutical Analysis, ASBASJSM College of Pharmacy, BELA (Ropar), Punjab, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1200-09

1200-1209

2773

1293

36.

ANTIOXIDANT ACTIVITY OF CULTURED MYCELIUM OF TEN DIFFERENT SPECIES OF OYSTER MUSHROOM, PLEUROTUS: A COMPARATIVE STUDY

The antioxidant activity of cultured mycelia of ten species of the oyster mushroom, Pleurotus species namely P. ostreatus, P. flabellatus, P. sapidus, P. citrinopileatus, P.roseus, P.sajor-caju, P.florida, P.cystidouses, P.fossulatus, and P.eryngii was examined. The extracts were screened for their ability to scavenge DPPH, hydroxyl, superoxide radicals and also for ferric reducing power and lipid...

B. Nitha, T.P. Smina, R and K.K. Janardhanan

Department of Microbiology, Amala Cancer Research Centre, Thrissur, Kerala - 680555, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1210-16

1210-1216

1883

758

37.

DETECTION OF ACTIVE CONSTITUENTS FROM THE LEAF EXTRACT OF LANNEA COROMANDELICA BY GC-MS TESTING AND ASSESSMENT OF ITS PHARMACOLOGICAL ACTIVITY

Lannea coromandelica (Anacardiaceae) is a tropical tree commonly called as Indian ash tree. Its various parts is said to possess medicinal property and used in Ayurveda and other ancient system of medicine for the treatment of various ailments including treatment of inflammation, gout, cholera, leprosy, vaginal troubles etc. Its Pharmacological study revealed anti-inflammatory, antimicrobial, hy...

Deepa Selvaraj *, Anusha Kotapadu, Bandla Sampurna, Balaji P, Aleena Ann Abraham, Sathesh Kumar Kesavan and Chitra Krishnan

Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1217-21

1217-1221

1791

697

38.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR ESTIMATION OF GLIMEPIRIDE AND METFORMIN HYDROCHLORIDE

An Accurate, sensitive, precise and stability indicating high performance thin layer chromatographic method has been developed and validated for the estimation of Glimepiride and Metformin hydrochloride. The method was developed using TLC aluminium plates precoated with silica gel 60F254 as the stationary phase and 0.5% Ammonium Sulfate: Methanol (7.5:2.5 v/v) as mobile phase. Densitometric analys...

Kinnari K. Patel, Vaishali V. Karkhanis and Mrs. Shital S. Gajjar

A.R. College of Pharmacy, Vallabh Vidhyanagar - 388120, Dist: Anand, Gujarat, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1222-29

1222-1229

2263

701

39.

VALIDATED STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL, TRAMADOL AND DICYCLOMINE IN TABLETS

A new simple stability indicating reversed-phase liquid chromatographic method has been developed and validated for simultaneous estimation of Paracetamol, Tramadol and Dicyclomine in combined pharmaceutical dosage form. An Agilent Zorbax SB C18 (250mmx4.6mm, 5microns) column with mobile phase containing ammonium acetate: acetonitrile (700:300 v/v) was used. The flow rate was maintained at 1.0 mL/...

Shivakumar Reddy L. *, Prasad Reddy S. L. N , Srinivas Reddy G. and Surender Reddy L.

Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(3).1230-40

1230-1240

2365

2188

40.

EVALUATION OF ANTICANDIDAL ACTIVITIES OF SPIRULINA METABOLITE AGAINST CANDIDA ALBICANCE

In this pilot study, Zarrouk medium was optimized in terms of biomass production and metabolites for the culture growth of, Spirulina species; Spirulina maxima and Spirulina platensis and their extract were tested against a nosocomial fungal species Candida albicans (C. albicans) to explore anticandidal activity. The corresponding growth and metabolite were measured in terms of turbidity, chloroph...

Pragya Mishra and Sheo Mohan Prasad *

Ranjan Physiology and Biochemistry Laboratory, Department of Botany, University of Allahabad, Allahabad, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1241-47

1241-1247

2133

830

41.

IMPACT OF PHYSICO-CHEMICAL PARAMETERS ON GILLS OF FRESHWATER CRAB BARYTELPHUSA CUNICULARIS (WESTWOOD, 1836)

Environmental pollution is one of the undesirable side effects of industrialization and found responsible factor for environmental degradation. Water samples and  crabs Barytelphusa cunicularis were collected  from  Gadhinglaj tahsil  and  analyzed  for  Physico- chemical  parameters  and heavy  metals respectively. The results  showed  high  range  of  pH  and  high  values  of...

Seema Shrishailappa Sakhare * and Nitin Anandrao Kamble

Department of Zoology, Shivaji University, Kolhapur, M. S., India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1248-57

1248-1257

1632

780

42.

SYNTHESIS OF MACROCYCLIC LIGANDS AND THEIR COBALT(II) COMPLEXES SPECTRAL CHARACTRIZATION AND ANTIMICROBIAL STUDIES

Complexes of Co(II) with macrocylic ligands i.e., 2, 3, 9, 10 tetraphenyl – 1, 4, 8, 11 – tetraazacyclotetradeca – 1, 3, 8, 10 tetraene (BDP), 2, 4, 10, 12 – tetramethyl – 1, 5, 9, 13 tetraazacyclohexadeca 1, 4, 9, 12 tetraene (ADP), 2, 3, 9, 10 tetramethyl 1, 4, 8, 11 tatraazatetredeca – 1, 3, 8, 10 tetraene (DDP) have been synthesized. All these complexes were characterized by elemen...

Sulekh Chandra *and Poonam Pipil and Swati Agarwal

Department of Chemistry,Zakir Husain Delhi Collage (University of Delhi), New Delhi, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1258-65

1258-1265

1576

776

43.

DESIGN, DEVELOPMENT AND EVALUATION OF MICONAZOLE NITRATE TOPICAL GEL FOR FUNGAL INFECTIONS

In this investigation, Miconazole Nitrate topical gels were designed by employing various bioadhesive polymers like polyacrylates (carbopol 940), cellulose derivatives (hydroxyl propyl methyl cellulose and sodium carboxy methyl cellulose) and natural polymers (sodium alginate) alone and in combination. The prepared gels were also characterized for different parameters like visual appearance, pH, c...

S. Nagalakshmi,* Radhika Ramaswamy, Renuga, Sowjanya, Premalatha, Vijayanjani and S. Shanmuganathan

Department of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu, India.

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1266-72

1266-1272

2840

1073

44.

EVALUATION OF ANTIOXIDANT ACTIVITIES OF ALGAE AND EFFECT OF SOLVENT EXTRACTION SYSTEM

The present communication is mainly focused to study   the antioxidant activities of the four different extracts (benzene, chloroform, acetone and methanol) of five algae including Aphanothece pallida, Anabena variabilis, Aphanothece saxicola, Lyngbya major, Nitella flagelliformis.  The total phenolic content varied from 2.99±0.23 to 25.38±0.22 mg/g, 4.20±0.135 to 14.10±0.13 mg/g, 3.07±0.2...

Tapan Seal *, Nilu Halder, Kausik Chaudhuri and Sankar Narayan Sinha

Plant Chemistry Department , Botanical Survey of India, A. J. C. Bose Indian Botanic Garden, Shibpur, Howrah, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1273-78

1273-1278

1791

597

45.

FLUORESCENCE ANALYSIS OF TWO MEDICINAL PLANTS – PSIDIUM GUAJAVA L AND CITRUS AURANTIUM

The plants used for the present study viz., Psidium guajava L and Citrus aurantium belong to the family Myrtaceae and Rutaceae respectively. Guava is native to tropical America. The young leaves are used as tonic in digestive disorders. Bitter orange is native of South Eastern Asia; grow in Tamil Nadu, Karnataka, Maharashtra, Punjab and Uttar Pradesh. It is a rich source of provitamin A. The prese...

V. Gayathri * and D. Kiruba

Department of Botany, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore – 641 043, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1279-82

1279-1282

5653

908

46.

Ru (III) AZO SCHIFF BASE COMPLEXES: SYNTHESIS, SPECTRAL CHARACTERIZATION, ANTIMICROBIAL AND ANTICANCER STUDIES

The complexes of Ru(III) having general formula [Ru(L)Cl(PPh3)] where L= azo Schiff base derived from 2-aminopyridine, 2-hydroxy naphthaldehyde /vanillin and ethylene diamine have been synthesized. The ligands as well as complexes have been characterized by elemental analysis, molar conductance, magnetic susceptibility, infra-red and electronic spectral data. The azo Schiff base ligand acts as a t...

R. Suchithra , P. Sounthari, A. Kiruthika, S. Chitra *, K. Parameswari and J. Vijitha

Department of Chemistry, P.S.G.R. Krishnammal College for Women, Coimbatore – 641004,Tamil Nadu, India.

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1283-93

1283-1293

2322

721

47.

A STUDY ON DISTRIBUTION OF PROTEIN, LIPIDS AND CARBOHYDRATES IN MUSCLE AND LIVER OF MARINE ASSOCIATED UPENEUS VITTATUS

Fish makes a vital contribution to the survival and health of a significant portion of the world’s population. Upeneus vittatus, a marine species found in the coast of Bay of Bengal, Visakhapatnam was selected for the present study. An attempt is made to know the distribution of Protein, lipids and carbohydrates in muscle and liver of infected and normal Upeneus vittatus. It is observed that a s...

D. Udaya Kumar Y., V. Christopher, Sobha Rani D., and Nagendra Sastri Yarla *

Department of Biochemistry and Bioinformatics, School of Life Sciences, Institute of Science, GITAM University, Visakhapatnam - 530045, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1294-01

1294-1301

1968

560

48.

COMPARATIVE EFFICACY OF HOMOEOPATHY, COGNITIVE BEHAVIOR THERAPY AND PLACEBO ON DEPRESSION

Depression produces serious emotional and psychological disorders and has severe consequences if not managed at proper time .With the progression of emotional load of depression one is unable to cope up with the extreme negative feelings and tend to create the world of their own thoughts which may end with the end of their life. Whatever forms of symptoms may be related to the grief, depression is...

Girija Shankar Shukla *, Pramod Kumar Rai and Danish Ahmed

Faculty of Health Sciences , Sam Higginbottom Institute of Agriculture, Technology & Sciences-Deemed University, Allahabad, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1302-01

1302-1313

2630

541

49.

PREPARATION AND EVALUATION OF SUSTAINED RELEASE MICROSPHERES OF CINNARIZINE USING EUDRAGIT RS100

Cinnarizine was microencapsulated with Eudragit RS100 using an o/o and o/w emulsion solvent evaporation technique. The effects of three formulation variables including the drug: polymer ratio, emulsifier (polyvinyl alcohol) concentration and volume of external medium on the entrapment efficiency and microspheres size distribution were examined. The drug release rate from prepared microspheres and ...

Akankasha Madhok*and Shivangi Madhok

Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela-140 111, District: Ropar, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1314-25

1314-1325

1933

1029

50.

IMPORTANCE OF PHARMACIST INTERVENTION IN THE MANAGEMENT OF ULCERATIVE COLITIS- A CASE STUDY

Ulcerative colitis is gaining more prominence these days because of its complications (both local and systemic), impairing the quality of life of patient and increased morbidity and mortality rate. For instance, a case was reviewed which proved the role of clinical pharmacist in the treatment plan and in providing a cost effective therapy. The review of the case resulted in a dosage error and pres...

Sindhuja Chellangi *, Sudha Rani Pokala, Raghuram Vantipalli and Rama Rao Nadendla

Department of Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-522034, Andhra Pradesh, India.

DOI: DOI: 10.13040/IJPSR.0975-8232.6(3).1326-29

1326-1329

1826

940

51.

A STUDY ON ANTIMICROBIAL POTENTIAL OF TRIDAX PROCUMBENS (L.) AGAINST CLINICAL ISOLATES

In-vitro antibacterial and antifungal activity of Tridax procumbens plant parts (leaf and stem) were investigated by agar well diffusion method. The petroleum ether, methanol and aqueous extracts of the plant parts were tested against two bacterial strains i.e., Bacillus subtilis and Escherichia coli and two fungal strains i.e., Trichoderma reesei and Fusarium oxysporium. The results of antibacter...

Ankita Jain *, DV Rao , Amla Batra and Amita Jain

Plant Biotechnology Lab, Department of Botany, University of Rajasthan, Jaipur-302044, Rajasthan, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1330-35

1330-1335

2961

840

52.

BUCCAL MIDAZOLAM: COULD IT BE AN ALTERNATIVE FOR I/V DIAZEPAM FOR ACUTE SEIZURES IN MALNOURISHED CHILDREN

Acute convulsive disorders are the most frequent neurological disorders in children which require emergency drug treatment. Immediate management of a convulsive episode is must as, delay can lead to status epilepticus, which is a significant cause of neurological morbidity and mortality among children. Benzodiazepines especially diazepam is often used as first line and routinely administered intra...

Jyotsna Sharma* Alka Agrawal , V S Chopra , Preeti Gaur and Sanjay Jhingran

House No. 15, Sector 15 (Duplex) Vasundhara, Ghaziabad. Uttar Pradesh 201012, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1336-41

1336-1341

1566

734