Pages Menu
TwitterRssFacebook
ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

Categories Menu

Volume 6 (2015) - Issue 12, December

Review Articles

 
Title
Views
PDF
Cited
1.

RECENT APPROACHES AND PHARMACEUTICAL APPLICATIONS OF NATURAL POLYSACCHARIDES: A REVIEW

Polysaccharides obtained from gums and mucilages are extensively used natural materials for conventional and novel dosage forms. Many natural gums are studied for use in novel drug delivery systems out of which polysaccharides, resins and tannins are most extensively studied and used. Because of advances in drug delivery technology, natural polysaccharides are included in novel drug delivery to fu...

R. Khathuriya *, T. Nayyar , S. Sabharwal, U. K. Jain and R. Taneja

Chandigarh College of Pharmacy, Landran, Mohali, Punjab, India

DOI: dx.doi.org/10.13040/IJPSR.0975-8232.6(12).4904-19

4904-19

3645

3368

2.

BIOCHEMICAL MECHANISMS OF ETOPOSIDE; UPSHOT OF CELL DEATH

Etoposide is an antineoplastic agent employed for healingvarious malignancies in human. It is a semi-synthetic derivative of podophyllotoxin and was introduced in 1971. The primary mode of action of etoposide is the inhibition of the function of the enzyme topoisomerase II. It stabilizes DNA-enzyme complex, and accumulation of this complex enhances the probability of double-stranded DNA breaks. Ho...

Maria Fareed Siddiqui*, Mehwish Muqaddas and Salman Sarwar

Centre for Research in Molecular Medicine (CRiMM), The University of Lahore, Lahore, Pakistan

DOI: 10.13040/IJPSR.0975-8232.6(12).4920-39

4920-39

4151

1248

3.

A SYSTEMATIC REVIEW OF SOME POTENTIAL ANTI-DIABETIC HERBS USED IN INDIA CHARACTERIZED BY ITS HYPOGLYCEMIC ACTIVITY

In the last few years, there has been an exponential growth in the field of herbal medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects. The World Health Organization (WHO) has listed 21,000 plants, which are used for medicinal purposes around the world. Among these 2500 species are in India, out of which 1...

T. K. Ujwala, Shawn Tomy, Sandra Celine and J. Sam Johnson Udaya Chander *

Pharm D Interns, RVS College of Pharmaceutical Sciences, Coimbatore, TN, India

DOI: 10.13040/IJPSR.0975-8232.6(12).4940-57

4940-57

4996

2589

4.

IN SITU GEL -SUSTAINED NASAL DRUG DELIVERY

In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the nasal cavity, but once administered, undergo gelation in situ, to form a gel. The formation of gel depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. In the r...

Manisha Rokade*, Bhavna Tambe and Manjula Ruparel

Department of pharmacy, S.M.B.T. Institute of Diploma of Pharmacy Dhamangaon, Nashik, MS, India

DOI: 10.13040/IJPSR.0975-8232.6(12).4958-66

4958-66

4299

1564

5.

SYNERGISTIC PHARMACOLOGICAL EFFECTS OF PHYTOCHEMICALS DERIVED FROM GINGER, GARLIC AND TULSI

This review article is focused at highlighting the therapeutic values of phytochemicals derived from the natural herbs ginger, garlic and tulsi. It is shown that the phytochemicals derived from these natural herbs work synergistically and exert similar pharmacological profile. The main actions include antioxidant and anti-inflammatory properties. Recommendations are made to follow the antioxidant ...

Prakhar Shukla , Sweta Sharma, Arpita Yadav * and Veejendra K. Yadav

University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(12).4967-81

4967-81

3879

1563

6.

THERAPEUTIC POTENTIAL OF HYPERICUM PERFORATUM: A REVIEW

The irreversible effects of modern therapies and increasing drug resistance have augmented our reliance on medicinal plants for herbal remedy against the deadly and infectious diseases. Hypericum perforatum or St. John’s wort (SJW) family Clusiaceae has been used to treat depression, mental disorders, wounds, peptic ulcers, malaria, gout and arthritis. Various compounds of the plant are known as...

Mansi Shrivastava* and L. K. Dwivedi

Institute of Biomedical Sciences, Bundelkhand University, Jhansi, UP, India

DOI: 10.13040/IJPSR.0975-8232.6(12).4982-88

4982-88

3044

803

7.

REGULATORY PROCESS FOR IMPORT AND EXPORT OF DRUGS IN INDIA

This article mainly focuses on the approval process of drug import and export from India. Now a day’s foreign pharmaceutical companies have a better legal foundation for releasing new drugs in India. The Indian medical regulatory system has become more complicated, and new drugs can take a year or more to be approved for marketing. Ever-changing laws and regulations are driving demand for regula...

V. Senthil *, R. Baviya Priyadharshini, A. Ramachandran, GNK Ganesh and Amber Shrivastava

Department of Pharmaceutical Regulatory Affairs, JSS College of Pharmacy, Ootacamund, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(12).4989-99

4989-99

47494

3824

8.

PHARMACOTHERAPY OF ALZHEIMER’S DISEASE: A REVIEW

Alzheimer’s disease, the most common cause of dementia is not a normal part of aging and worsens over time. The most common early symptom of Alzheimer's is difficulty remembering newly learned information. Microscopic changes in the brain begin long before the first signs of memory loss. Two abnormal structures called plaques and tangles are prime suspects in damaging and killing nerve cells. Cu...

Sachin Satpute *, Vilas Shingare and Manthan Mehta

Department of Pharmacology, Topiwala National Medical College & B Y L Nair Ch. Hospital, Mumbai Central, Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5000-05

5000-05

2668

798

9.

HEPATOPROTECTIVE MEDICINAL HERBS AND ANIMAL MODELS FOR THEIR SCREENING – A REVIEW

The liver is a vital solid organ in the upper abdomen that helps in digestion, detoxification and has other synthetic, metabolic and storage functions. Liver diseases are a major problem worldwide; viral hepatitis, alcohol, malnutrition, autoimmune and drugs being most important causes.  Currently there is no way to compensate for the absence of liver function in the long term and liver transplan...

Qadrie Z. L. *, B. Rajkapoor and S. Kavimani

Department of Clinical Pharmacology, SKIMS, Srinagar J & K, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5006-28

5006-28

2710

2822

Research Articles

 
Title
Views
PDF
Cited
10.

AN IN VITRO STUDY ON THE EFFECT OF PISTACIA ATLANTICA SUB KURDICA EXTRACT ON MICROTUBULE PROTEINS: A POTENTIAL ANTI-CANCER COMPOUND

Natural products derived from plants and herbs have always had an important role in drug development. Especially in case of cancer, there is a huge demand for effective chemopreventive and chemotherapeutic agents with natural base and low toxic effects on normal non-cancerous cells. In this work, we have studied the effects of Pistacia atlantica sub kurdica (Baneh) extract on microtubule proteins ...

B. H. Shafiei, M. Dehghan Shasaltaneh, S. M. Ghaffari, S. Ahmadian, M. Kamarehei and G. H. Raizi*

Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran

DOI: 10.13040/IJPSR.0975-8232.6(12).5029-39

5029-39

2746

1160

11.

FORMULATION DESIGN, IN-VITRO AND BIOLOGICAL CORRELATION OF SITE SPECIFIC DRUG DELIVERY SYSTEM FOR DISTAL GASTRO-INTESTINAL TRACT

The present study was designed to evaluate oral compression coated tablet formulation to achieve time and site specific drug release system to target lower GIT. A pectin based compression coated tablet formulation of different ratios and concentration of ethyl cellulose and cellulose acetate phthalate were designed and evaluated physico chemical parameters and for tinidazole release, compression c...

Mohammed Jameel Patel*, Kais Alobaidy, Farouk M Sakr and Lokesh Shetty

Department of Pharmacy and Allied medical sciences, Riyadh colleges of Dentistry and Pharmacy, P.O. Box 84891, Riyadh 1168, Kingdom of Saudi Arab

DOI: 10.13040/IJPSR.0975-8232.6(12).5040-46

5040-46

3057

1033

12.

SPECIFIC TARGETING OF FOLATE RECEPTOR BY METHOTREXATE CONJUGATED MODIFIED MAGNETIC NANOPARTICLES: ENZYMATIC RELEASE AND CYTOTOXIC STUDY

Magnetic nanocarriers have been used for specific drug delivery to release therapeutic drugs into target cancer cells. We used bifunctional methotrexate (MTX) conjugated magnetic nanoparticles (MNPs) (~37 nm) engineered by dopamine–polyethylene glycol to targeted folate receptor (FR)-positive cancer cells. For this purpose, MTX was chemically loaded on to MNPs with N, N-dicyclohexylcarbodiimide ...

Azam Sargazi, Keramat Kuhestani, Tayebe Nosrat Nahoki and Mostafa Heidari Majd*

Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran

DOI: 10.13040/IJPSR.0975-8232.6(12).5047-55

5047-55

2845

1330

13.

CHARACTERIZATION AND SCREENING OF BIOACTIVE COMPOUNDS IN THE EXTRACT PREPARED FROM AERIAL ROOTS OF FICUS BENGHALENSIS

Ficus benghalensis is has been used in traditional medicinal practices such as Ayurveda, Unani, Siddha and homoeopathy. All parts of the tree such as fruits, aerial roots, bark and leaves are known to be traditionally associated with diarrhea, dysentery, menorrhagia, nervous disorders and tonic properties. However, in Ayurveda it is mainly known for the diabetes treatment.There are no reports givi...

Vipin Kumar Verma , Neeta Sehgal and Om Prakash *

Department of Zoology, Sri Venkateswara College, University of Delhi, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5056-69

5056-69

4001

1678

14.

ANALYTICAL METHOD VALIDATION FOR DETERMINATION OF RELATED SUBSTANCES OF DEXMEDETOMIDINE (IMPURITY-1) IN DEXMEDETOMIDINE HYDROCHLORIDE INJECTION

Dexmedetomidine, approved by the Food and Drug Administration (FDA) in 1999 as a sedative for use in the intensive care unit, is a potent and highly selective α2-adrenoceptor agonist with significant sedative, analgesic and anxiolytic effects mostly used in the intensive care units. This article describes validation for determination of related substances of dexmedetomidine (impurity-1) in dexmed...

Muralee Krishna, Meghana Nadre, Anirudhha Sherikar and Ranjith Reddy *

Glenmark pharmaceutical Limited, Pithampur, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5070-76

5070-76

4110

1982

15.

DEVELOPMENT AND OPTIMIZATION OF EFFERVESCENT TABLETS OF PROMETHAZINE

The objective of present study was to develop effervescent tablets of promethazine (PMZ) for the treatment of emesis. Effervescent tablets were prepared by direct compression method and were optimized using 32 full factorial design. Amount to sodium starch glycolate(X1) and amount of sodium bicarbonate (X2) were selected as independent variables, whereas disintegration time (Y1), amount of carbon ...

Amit A. Patel, R.H. Parikh, Om Prakash Sharma and Tejal A. Mehta *

Institute of Pharmacy, Nirma University, S.G. Highway, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5077-84

5077-84

3023

1173

17.

EFFECT OF ACAMPROSATE IN EXPERIMENTAL MODELS OF PERIPHERAL NEUROPATHIC AND INFLAMMATORY PAIN IN WISTAR RATS

Neuropathic pain is a persistent chronic pain caused by primary lesion or dysfunction of neurons which is primarily characterized by hyperalgesia, allodynia. There is some evidence that acamprosate might inhibit Ca2 influx through NMDA and voltage-dependent Ca2 channels. λ-carrageenan (0.1 ml of 1% w/v) into i.pl. region of the hind paw was injected to produce acute inflammation. Unilateral perip...

G. Khanna * and K. R. Bijjem

Department of Pharmacy, Christian Medical College and Hospital, Brown road, Ludhiana, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5102-14

5102-14

2228

737

18.

DESIGN EXPERT-SUPPORTED DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) METHOD FOR DETERMINATION OF RESVERATROL IN BULK DRUG AND PHARMACEUTICAL FORMULATION

The aim of the present study was to develop and validate a new, simple, selective and economical stability indicating RP-HPLC method for the quantitative determination of resveratrol in bulk drug and pharmaceutical formulations. A Box-Behnken design supported optimization was carried out to identify the optimum chromatographic conditions. The developed method was validated for linearity, range, ac...

Rudra Pangeni, Javed Ali, Gulam Mustafa, Shrestha Sharma and Sanjula Baboota *

Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5115-25

5115-25

3062

913

19.

FORMULATION DESIGN, IN-VITRO AND BIOLOGICAL CORRELATION OF SITE SPECIFIC DRUG DELIVERY SYSTEM FOR DISTAL GASTRO-INTESTINAL TRACT

In the present studies was designed to evaluate oral compression coated tablet formulation to achieve time and site specific drug release system to target lower GIT. A pectin based compression coated tablet formulation of different ratios and concentration of ethyl cellulose and cellulose acetate phthalate were designed and evaluated physico chemical parameters and for tinidazole release, compress...

Mohammed Jameel Patel*, Kais Alobaidy, Farouk M. Sakr and Lokesh Shetty

Department of Pharmacy and Allied medical sciences, Riyadh colleges of Dentistry and Pharmacy, Riyadh, Kingdom of Saudi Arab

DOI: 10.13040/IJPSR.0975-8232.6(12).5126-33

5126-33

1862

706

20.

ANTIOXIDANT ACTIVITIES OF FIVE WILD EDIBLE FRUITS OF MEGHALAYA STATE IN INDIA AND EFFECT OF SOLVENT EXTRACTION SYSTEM

The antioxidant activities of five wild edible fruits e.g. e.g. Debregeasia longifolia, Helicia erratica, Ilex venulosa, Rhus semialata and Spondias axillaris collected from Meghalaya state in India were determined  by using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, ABTS radical scavenging ability, reducing power capacity, estimation of total phenolic content, flavonoid c...

Tapan Seal* and Kaushik Chaudhuri

Plant Chemistry Department, Botanical Survey of India, A. J. C. Bose Indian Botanic Garden, Shibpur, Howrah, West Bengal, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5134-40

5134-40

2280

815

21.

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF WITHAFERIN-A IN RANGER CAPSULE

A simple, accurate, precise and robust reverse phase High Performance Liquid Chromatographic method has been developed and validated for the estimation of Withaferin-A in polyherbal formulation namely Ranger Capsule. The chromatographic method was carried out isocratically with Phenomenex Luna C18 (2) (4.6 x 250 mm, 5 μ) and good resolution was achieved with acetonitrile: water (60: 40v/v) mobile...

N. Gurav *, B. Solanki, I. Gadhvi , P. Patel and D Sen

Vasu Research Center, A Division of Vasu Healthcare Pvt. Ltd. G.I.D.C, Makarpura, Vadodara, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5141-46

5141-46

2844

966

22.

GC-MS ANALYSIS OF PHYTOCOMPONENTS IN JUICE SAMPLE OF INDIAN CANE: SACCHARUM BARBERI

Sugarcane is the major cash crop of the Indian tropical and sub-tropical region. Mostly the foremost part of Indian economy is based on sugarcane crop, which is cultivated major state in India. Phyto-components are the compound that occurred in plant naturally and play important role for biologically activity (Anti fungal, Anti cancer Anti diabetic etc), to prevent the many disease, scavenging and...

Manish Dev Sharma *, Indra Rautela , Nishesh Sharma, Manoj Gahlot and Eapen P Koshy

Department of Molecular and Cellular Engineering, Jacob School of Biotechnology, Sam Higginbottom Institute of Agriculture, Technology and Science, Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5147-53

5147-53

2640

1684

23.

ANTI-INFLAMMATORY ACTIVITY OF THE AERIAL PARTS EXTACTS OF CAESALPINIA MIMOSOIDES LAMK

Caesalpinia mimosoides Lamk. is a prickly climbing shrub belongs to Leguminosae family. various parts of this plant have been used in the treatment of ulcer, inflammation, wound healing  and arthritis. The present study aimed at the evaluation of anti inflammatory property of different extracts of aerial parts by in vitro and in vivo methods. In vitro methods were estimated by protein denaturatio...

V. V. Lakshmi * and S. P. Bobby

Department of Pharmaceutical Chemistry, University College of Pharmacy, MG University, Cheruvandoor campus, Kottayam, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5154-58

5154-58

2133

943

24.

EFFECT OF LIFESTYLE MODIFICATIONS ON BLOOD PRESSURE IN HYPERTENSIVE PATIENTS

Aim: The aim of the study is to assess effect of lifestyle modifications and implementation of DASH diet in daily life on blood pressure in hypertensive patients. Method: A prospective observational study was conducted for a period of six months from Dec- 2013 to May-2014. The data was collected by self prepared form and analyzed using descriptive statistics. Counselling on lifestyle changes and i...

D. Guru Prasanna *, C. Gopinath, K.B. Yadavender Reddy, D. Giri Rajasekhar, P. Chandrakanth and S. Sravanakumari

Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet, Andhrapradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5159-63

5159-63

2840

972

25.

DEVELOPMENT OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CEFTRIAXONE SODIUM IN DIFFERENT BRANDS OF PHARMACEUTICAL PREPARATION INVOLVING DIAZOTIZATION

A simple, precise, and robust spectrophotometric method for the determination of Ceftriaxone sodium has been investigated and validated. The proposed chemical reaction involved involves the reaction primary amine of Ceftriaxone sodium with nitrite solution in acidic medium to form a diazotized product followed by the reaction of the diazotized product with suitable coupling reagent to obtained a c...

Sajjad Ali Ilyas, Muhammad Imran *, Naresh Kumar, Jasmin Shah, M. Rasul Jan, Zohra Kousar and Muhammad Aslam

Department of Chemistry, University of Azad Jammu & Kashmir, Muzaffarabad, Pakistan

DOI: 10.13040/IJPSR.0975-8232.6(12).5164-73

5164-73

2389

878

26.

HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND OLOPATADINE IN ITS COMBINED DOSAGE FORMS

High performance thin layer chromatographic method has been developed for the determination of Olopatadine (OLO) and Montelukast (MONT) in their combined dosage form. Merck HPTLC aluminum plates of silica gel G60 F254, (10 × 10 cm) was used for separation of combined with 250 μm thickness using Chloroform: Ethyl acetate: Methanol: Triethylamine (6: 4.5: 2.5: 0.8, v/v/v/v) as mobile phase. HPTLC ...

Hitesh. J. Vekaria * and Rakesh kumar Jat

Institute of Pharmacy, JJT University, Jhunjhunu, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5174-78

5174-78

2184

1033

27.

QUANTITATIVE DETERMINATION OF DRUGS BY USING CERIUM (IV) AND RHODAMINE B COUPLE: A SPECTROPHOTOMETRIC STUDY

Simple, sensitive, accurate and precise spectrophotometric methods for quantitative determination of five drugs viz., Tramadol Hydrochloride (TDH) , Dobutamine (DOB), Trimetazidine (TRMZ), Terazocin (TRZ) and Esmolol (ESM)  were developed. The method for each drug depends upon oxidation of drugs by Ce (IV) (Excess) and estimating the amount of un reacted Ce (IV) by Rhodamine-B dye at 557 nm. The ...

M. Sasikala, B. Tirupati and G.Venkateshwarlu *

Department of Chemistry, University college of science, Osmania university, Hyderabad, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5179-87

5179-87

2317

1073

28.

ANTI-INFLAMMATORY ACTIVITY OF TRANS-CINNAMALDEHYDE AND PIPERINE COMBINATION AGAINST CARRAGEENAN INDUCED PAW EDEMA

Inflammation is one of the unique mechanism that help body to protect itself against burn, infection, allergens, toxic chemicals, or other noxious stimuli. It is a defense reaction of the body in order to eliminate or reduce the spread of injurious agent. However, over reaction of the body may be harmful or undesirable. This has resulted in extensive development of anti-inflammatory drugs. Despite...

Swapnil A. Jadhav * and Kedar Prabhavalkar

SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle(West), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5188-92

5188-92

2329

921

29.

EFFECT OF FIVE DIFFERENT CULTURE MEDIA ON MYCELIAL GROWTH OF AGROCYBE AEGERITA

A preliminary experiment was carried out to analyse the growth performance of Agrocyba aegerita mushroom cultures using chemosynthetic media. This study is mainly aimed to different media such as Yeast Malt Agar Medium (YMA), Saboraud’s Dextrose Agar Medium (SDA), Glucose Peptone Agar Medium (GPA), Malt Extract Agar Medium (MEA) and Potato Dextrose Agar Medium (PDA) on the growth of mycelium of ...

Nagalakshmi Muthu and Krishnakumari Shanmugasundaram*

Department of Biochemistry, Kongunadu arts and science college (Autonomous), Coimbatore – 641 029, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5193-97

5193-97

4073

920

30.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CANDESARTAN CILEXETIL IN BULK AND PHARMACEUTICAL DOSAGE FORMS BY THIRD ORDER DERIVATIVE SPECTROSCOPIC TECHNIQUE

Candesartan cilexetil, a prodrug is a racemic mixture containing one chiral center at the cyclohexyloxy-carbonyloxy- ethyl ester group. It is soluble in dimethyl formamide, acetone, methanol, 0.1 N sodium hydroxide solution and insoluble in water. Objective of the present study is to develop a simple, sensitive, accurate, precise and rapid derivative spectrophotometric method for the estimation of...

Gunjan Kalyani , Din Bandhu Dinanath Baghel and Dinesh Kumar Sharma

National Center for Natural Resources, Pt. Ravishankar Shukla University, Chhattisgarh, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5198-01

5198-01

2267

827

31.

INVESTIGATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CEFOTAXIME SODIUM IN DIFFERENT BRANDS OF PHARMACEUTICAL PREPARATIONS

A simple, precise, and robust spectrophotometric method for the determination of Cefotaxime sodium has been investigated and validated. The proposed chemical reaction involves the reaction of primary amine of Cefotaxime sodium with nitrite solution in acidic medium to form a diazotized product, followed by the reaction of the diazotized product with suitable coupling reagent resulting in a colored...

S. Ali Ilyas, Md. Imran *, N. Kumar, J. Shah, M. Rasul Jan, S. Fazil and Md. Khalid

Department of Chemistry, University of Azad Jammu & Kashmir, Muzaffarabad, Pakistan

DOI: 10.13040/IJPSR.0975-8232.6(12).5202-10

5202-10

2004

858

32.

QUANTIFICATION OF CHLORHEXIDINE GLUCONATE FROM MOUTH RINSE AND SKIN DISINFECTANT SOLUTIONS USING A VAIDATED CHROMATOGRAPHIC TECHNIQUE

The study presents a simple and rapid chromatographic technique for the estimation of chlorhexidine gluconate for mouth wash using a combination of phosphate buffer and acetonitrile as mobile phase. The separation was carried out on a stainless steel column 250mm × 4.5mm packed with octadecyle silane particles. The detection was carried out using a dual lambda absorbance detector at 254nm wavelen...

Amit Kumar De, Ashok Kumar Bera and Biswajit Pal*

Department of Chemistry, St. Paul’s C. M. College, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5211-16

5211-16

5506

1083

33.

PREPARATION AND EVALUATION OF PHYTOSOME OF LAWSONE

Lawsonia inermis L. (Lawsone) is reported to contain carbohydrates, proteins, flavonoids and phenolic compounds, alkaloids, terpenoids, coumarins, xanthones and fatty acids. The plant has also been reported to have hepatoprotective, anti-inflammatory, antibacterial, antifungal, antiviral, antioxidant and anticancer properties. Lawsone has low bioavailability because it is less soluble in water and...

Rudra Pratap Singh * and Ramakant Narke

Sinhgad College of Pharmacy, Vadgaon (BK.), Pune, Maharashtra, MS, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5217-26

5217-26

10292

1689

34.

EFFECT OF AZADIRACHTA INDICA ON HYPERGLYCEMIA INDUCED OXIDATIVE STRESS IN ALLOXAN DIABETIC RAT BRAIN

The present study evaluates antidiabetic effect of A. indica leaf extract (AILE) and A. indica bark extract (AIBE) on antioxidant enzymes in the brain of alloxan diabetic rats and compared with insulin treatment. The oral effective dose of A. indica leaf (500mg/Kg body weight) and A. indica bark (100mg/Kg body weight) was given once daily for 21days to separate groups of diabetic rats. At the end ...

S. F. Basir * and S. Shailey

Department of Biosciences, Jamia Millia Islamia, New Delhi - 110025, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5227-34

5227-34

1904

646

35.

FORMULATION AND IN-VITRO EVALUATION OF FLOATING EFFERVESCENT TABLETS OF RANITIDINE HYDROCHLORIDE

The main objective of the present work is to develop Floating Effervescent matrix tablets of Ranitidine hydrochloride using different polymers viz. hydroxy propyl methyl cellulose (HPMC), Xanthan gum and Guar gum. Varying ratios of drug and polymer like 1:0.6 and 1:1 were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the rele...

Afshan Meherose * and G. Udaya Bhanu

Malla Reddy Institute of Pharmaceutical Sciences Maisammaguda, Secunderabad, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5235-44

5235-44

3076

1469

36.

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR PSEUDOEPHEDRINE HYDROCHLORIDE AND FEXOFENADINE HYDROCHLORIDE IN TABLET DOSAGE FORM

High performance liquid chromatographic (HPLC) method was described for determination of Pseudoephedrine Hydrochloride (PSE) and Fexofenadine Hydrochloride (FEX). The chromatographic separation was achieved on Kinetex C18, (250 x 4.6 mm i.d), Particle size 5µm. The mobile phase contains a mixture of 0.005 M Dioctyl Sodium Sulfosuccinate Buffer in a mixture of 50 volume of Methanol, 10 volume of A...

E. A. Sharma * and N. J. Shah

School of Pharmacy, RK University, Rajkot, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5245-52

5245-52

5651

1104

37.

BUFFER AND EMULSIFIER OPTIMIZATION IN CREAM WITH ITS ANTIBACTERIAL ACTIVITY AND SENSITIVITY

Introduction: Green tea contains epigallocatechin gallate (EGCG) that widely use as antibacterial. Formulation development with buffer and emulsifier addition is needed to increase its stability and effectiveness. Buffer addition will increase EGCG stability while emulsifier will increase the cream stability. Objective: This study aimed to determine the optimal formulation from buffer combination ...

Naniek Widyaningrum *, Achmad Fudholi, Sudarsono, and Erna P. Setyowati

Faculty of Pharmacy, Gadjah Mada University, Indonesia

DOI: 10.13040/IJPSR.0975-8232.6(12).5253-58

5253-58

3377

1419

38.

SEA BUCKTHORN (H. RHAMNOIDES L.) MEDIATED ACUTE HYPOXIC TOLERANCE IN THE SKELETAL MUSCLE OF RATS BY DIFFERENTIAL ACTIVATION OF ENERGY METABOLISM AND ENHANCED ANTIOXIDANTS

Exposure to hypobaric hypoxia differentially affects physical performance and survival amongst individuals. The present study was designed to investigate the role of metabolic enzymes, antioxidants and bioenergetics molecular markers in the differential hypoxic tolerance of animals exposed to acute hypobaric hypoxia and the effect of herbal supplementation in augmentation of hypoxia tolerance. Adu...

G. K. Keshri, A. Gupta*, K. Jain, G. Suryakumar, P. Sharma, S. Gola, A. Yadav, S. Verma and L. Ganju

Defence Institute of Physiology and Allied Sciences, DRDO, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5259-72

5259-72

2006

780

39.

STUDIES ON FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF CELECOXIB MATRIX TABLET CONTAINING COMBINATION OF EQUAL RATIO OF NATURAL GUMS GUARGUM AND CYCLODEXTRIN, AMYLOSE AND PECTIN FOR COLON SPECIFIC DRUG DELIVERY

Backdrop: The design, development, formulation and in vitro evaluation of colon targeted drug delivery system with natural polysaccharides was studied with Guargum, Cyclodextrin, Amylose and Pectin. Hence it motivated us to find the combined effect of the natural polysaccharides with Celecoxib matrix tablet for specific targeting to colon. Process: Celecoxib matrix tablet was prepared by drug with...

P. Arulraj *, V. Gopal, G. Jeyabalan, C. S. Kandasamy, Sam Johnson J. Udaya Chander and R. Venkatanarayanan

Department of Pharmaceutical Biotechnology, RVS College of Pharmaceutical Sciences, Coimbatore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5273-78

5273-78

2301

862

40.

PARTIAL PURIFICATION AND ANTIOXIDANT ACTIVITIES OF METHANOL EXTRACTS OF ACORUS CALAMUS.

In vitro antioxidant activity test was carried out on partially purification of methanol extract of Acorus calamus. Partially purification was done to obtain ten fractions. Partial purification was carried out by using hexane: ethyl acetate solvent system. These fractions were studied for the polyphenolics and antioxidant activity. S6 –S9 fractions shows maximum   radical scavenging activity, ...

S. G. Funde

Dr. Shree Nanasaheb Dharmadhikari Arts, Commerce, & Science College Gove, Tal - Roha , Dist – Raigad Maharastra, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5279-83

5279-83

2096

958

41.

EXTRACTION, PURIFICATION OF BROMELAIN FROM PINEAPPLE AND DETERMINATION OF ITS EFFECT ON BACTERIA CAUSING PERIODONTITIS

The pineapple (Ananas comosus) is a multiple fruit belonging to the Bromeliaceae family, has a crude extract   Bromelain accumulated in the stem, fruit, peel and leaves of the pineapple which shows proteolytic activity. The present study was carried out to assess the accumulation of bromelain in the different parts of the pineapple. The techniques homogenization with sodium acetate buffer, follo...

Aravind Krishnan V. and M. Gokulakrishnan *

Department of Biotechnology, M S Ramaiah Institute of Technology, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5284-94

5284-94

13797

2687

42.

EVALUATION OF ANTIOXIDANT – PHYTOCHEMICAL COMPOUNDS IN PUNICA GRANATUM

The antioxidant activity of pomegranate fruit was evaluated using in vitro tests. Phenol content was more in G-137, 11.8±0.11 mg/g dry wt followed Arakta variety 10.1±0.05 mg/ g dry wt., respectively   flavonol and flavonoid content was high in mrudula 3.5±0.05 mg/g dry wt, 7.0±0.05 mg/g dry wt., and proanthocyanin content was high in Bhagwa variety 19.62±0.05 mg/g dry wt, Anthocyanin conte...

J. Sravanthi * and Gangadhar Rao S.

Department of Botany (Plant Physiology), Osmania University College of Science, Hyderabad, Telangana State, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5295-00

5295-00

2818

735

43.

IN-VITRO ANTI-INFLAMMATORY ACTIVITY OF SELECTED DIHYDROXY FLAVONE BY TPA INDUCED INFLAMMATION IN POLYMORPHONUCLEAR LEUCOCYTES

The present study involves the investigation of anti-inflammatory activity for 2’, 4’ dihydroxy flavone by TPA [12- O- Techanoyl 13 – Myristate] induced inflammation in Polymorphonuclear leukocytes [PMNL]. The cell viability was assayed by Trypan blue dye exclusion assay, MTT assay, release of Cathepsin D, Nitrite and TNF-α levels. Diclofenac sodium was used as the standard drug. The select...

S. Umamaheswari* and K. S. Sridevi Sangeetha

Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.6(12).5301-07

5301-07

1795

727

44.

EFFECT OF ETHANOL EXTRACT FROM MORUS ALBA LEAVES SUPPLEMENTATION ON GASTRIC TISSUE GLUTATHIONE LEVEL IN INDOMETHACIN INDUCED ULCERS IN RATS

Context: The leaves Morus alba have been traditionally used in Asian countries for treatment of different ailments. Objective: Present study was undertaken to evaluate the effect of ethanol extract from Morus alba leaves supplementation on gastric tissue glutathione level in indomethacin induced ulcers in rats. Materials and Methods: Ethanol extract from Morus alba leaves were administered at the ...

Phool Chandra*, Kamal Kishore and Ashoke Kumar Ghosh

Department of Physiology & Pharmacology, School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Delhi Road (NH-24), Moradabad-244 102 (UP), India.

DOI: 10.13040/IJPSR.0975-8232.6(12).5308-14

5308-14

2081

881

45.

STRATEGIES FOR ENHANCEMENT OF BIOAVAILABILITY OF MEDICINAL AGENTS WITH NATURAL PRODUCTS

In Advances drug design technologies, a large no of drug molecules are being introduced in every year but many of these molecules have problems like their solubility, stability, bioavailability and its long lasting side effects. Low bioavailability is one of the serious but curable problems in case of the drug molecule. Low bioavailability happens because a lot of molecules unable to permeation th...

Garima Jain and Umesh K. Patil *

Division of Natural Product Research Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India 470003

DOI: 10.13040/IJPSR.0975-8232.6(12). 5315-24

5315-24

4176

1109