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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 7 (2016) - Issue 3, March

Review Articles

 
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1.

BHUT JOLOKIA (CAPSICUM CHINENSE JAQC): A REVIEW

The northeast region of India, considered as ‘hot spot’ of biodiversity, having unique ecological environment with hot and high-humidity conditions, has given rise to the world’s hottest chilli, ‘Bhut jolokia or Bih jolokia’, which is at least two times hotter than Red Savina Habanero in terms of Scoville heat units (SHU). The Assamese word “bhut” refers to the typical large pod size...

Anupam Roy

Girijananda Chowdhury Institute of Pharmaceutical Science, Hatkhowapara, Azara, Guwahati, Assam- 781017, India

DOI: 10.13040/IJPSR.0975-8232.7(3).882-89

882-89

7937

1730

2.

TINOSPORA CORDIFOLIA: A PHYTOPHARMACOLOGICAL REVIEW

Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand for plant based medicines, health products, pharmaceuticals, food supplements, cosmetics etc. A review of chemical constituents present in various parts of Tinospora cordifolia and their pharmacological actions is given in the present article. Tinospora cordifolia, is a c...

Garish Joshi*and Rajandeep Kaur

CT Institute of Pharmaceutical Sciences Jalandhar, Panjab, India

DOI: 10.13040/IJPSR.0975-8232.7(3).890-97

890-97

11330

2163

3.

ADVERSE DRUG REACTIONS ASSOCIATED WITH ANTI-HYPERTENSIVE DRUGS AND ITS MANAGEMENT

Adverse Drug Reactions associated with drugs are common and impose a serious health related problem, which can limit the treatment options, compliance and even leads to discontinuation of therapy. Hypertension is a chronic disease condition which is considered to be one of the major cardiovascular risk factor. For the treatment of hypertension a wide range of anti-hypertensive agents are available...

R. Sudhakar *, Minu K. George, B. Yasaswini, N. Sundararajan and Ahamada Safna Mariyam M.

Nandha College of Pharmacy 1, Erode, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(3).898-05

898-13

6170

1132

4.

SCIENCE AND RISK BASED APPROACH TO THE PROCESS VALIDATION – LINK FROM QUALITY BY DESIGN TO PROCESS VALIDATION.

The approach to the process validation of pharmaceutical manufacturing processes has been changed and the minimal approach (traditional) is no longer recommended 1-6. As the regulatory requirements are being changed, considering the patient safety and drug efficacy, an enhanced and science based approach is recommended for the process validation of medicinal product manufacturing processes. The ma...

Prasad Kanuri

Executive – CQA, Vasudha Pharma Chem Limited, Jawaharlal Nehru Pharma City, Parawada, Visakhapatnam – 531019. India.

DOI: 10.13040/IJPSR.0975-8232.7(3).914-29

914-29

4833

1530

5.

EMERGING TRENDS IN COMPRESSION COATED TABLET DOSAGE FORMS: A REVIEW

Tablets are widely used and most preferred dosage form because of its ease of manufacture and administration, lower cost, good aesthetic appearance. Now a days new trends are going to develop in formulation of conventional tablet in to modified tablet dosage forms like floating, sustained release matrix, coated tablets, controlled release, fast release etc. This review provides the detail informat...

Purushottam R. Patil *, Vaibhav D. Bobade, Pankaj L. Sawant and Rajendra P. Marathe

Department of Pharmaceutics, Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(3).930--38

930-38

2717

1718

6.

UNDERSTANDING THE EVIDENCES AVAILABLE FOR USE OF TRANSDERMAL PATCHES IN THE TREATMENT OF ASTHMA – A REVIEW

Transdermal drug delivery systems (TDDS) offers a route that by-passes the gut and hence they are more convenient. They are also non-invasive and safer than the other alternatives. The transdermal or the adhesive patches are used to deliver a specific quantity of drug in a controlled release manner through skin for over a long period of time. There are many types of patches like the matrix, membra...

Sam Johnson Udaya Chander J., T. Akelesh and A. Anandhasayanam *

Department of Pharmacy Practice, JKKMMRF College of Pharmacy, Vattamalai, Komarapalayam, TN, India

DOI: 10.13040/IJPSR.0975-8232.7(3).939-44

939-44

2421

751

Research Articles

 
Title
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7.

SATURATION SOLUBILITY OF SCOPOLAMINE IN THIN FILMS OF POLYACRYLATE PRESSURE SENSITIVE ADHESIVES IS TEMPERATURE DEPENDENT

The method of drug uptake from solid solution has been used to measure the saturation solubility of scopolamine base in various pressure sensitive adhesive DURO-TAKs at elevated temperature. The saturation solubility was strongly temperature dependent, being 50 – 100 % larger at 45°C than at 25°C. The higher temperature also caused much more rapid approach to equilibrium distribution of the dr...

A. Kunst and G. Lee *

Division of Pharmaceutics, Friedrich-Alexander-University, Erlangen, Germany

DOI: 10.13040/IJPSR.0975-8232.7(3).945-50

945-50

2615

953

8.

ENHANCEMENT OF DOMPERIDONE DISSOLUTION RATE VIA FORMULATION OF ADSORBATES AND CO-ADSORBATES

The aim of this study was to enhance the dissolution rate of water-insoluble, weakly basic antiemetic drug; Domperidone (DMP), through the formulation of adsorbates and co-adsorbates. Adsorption of drug onto the surface of three different adsorbents; Avicel PH 101, Florite R and Aerosil 200 was studied and Langmuir adsorption isotherms were constructed.  Adsorbates of drug with the used adsorbent...

A.E. Aboutaleb, S. I. Abdel-Rahman, M. O. Ahmed and M. A. Younis *

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(3).951-60

951-60

2599

740

9.

SYNTHESIS OF QUINOLINE DERIVATIVES BY REACTION OF DIMETHYL(2R,3S,4R)-2-PHENYL-4-(PHENYLAMINO)-1,3,4-TRIHYDROQUINOLINE-2,3-DICARBOXYLATE WITH SOME AMINES

In this work, quinoline derivatives were synthesized from reaction of aniline, benzylaldehyde and dimethylacetylene dicarboxylate (DMAD) in sequent steps to provide quinoline derivative dimethyl (2R, 3S, 4R)-2-phenyl-4-(phenylamino)-1, 3, 4-trihydroquinoline-2,3-dicarboxylate (12). Compound (12), was reacted with some amines such as  hydrazine hydrate, urea, thiourea, ethylenediamine, diaminoprop...

Isra' I. Salih Ad-Daraji and Abdulmajeed S.H. Al Samarrai *

Department of Applied Chemistry, College of Applied Science, University of Samarra, Salahalddin, Iraq.

DOI: 10.13040/IJPSR.0975-8232.7(3).961-67

961-67

2690

842

10.

HPMC BASED EXTENDED-RELEASE MATRIX TABLETS OF AN ANTI-PSYCHOTIC DRUG BY DRY GRANULATION METHOD

The aim of the present study was to develop and characterize an oral sustain release drug delivery system for commonly prescribed antipsychotic Quetiapine fumarate. Hydrophilic matrix based tablets using different concentrations of hydroxypropyl methylcellulose (HPMC) viz. K4M CR was developed using dry granulation technique. The prepared tablets were of 400 mg dose and were designed for once- dai...

Himankar Baishya *, Athappan Chidambaram and Zhao Haitao

Formulation Development Department, Beijing Sciecure Pharmaceuticals Co., Ltd., Beijing, China

DOI: 10.13040/IJPSR.0975-8232.7(3).968-75

968-75

3466

1082

11.

ANALYSIS OF TUMOR NECROSIS FACTOR G238A AND G308A GENE POLYMORPHISMS IN TUNISIAN PATIENTS WITH PRESSURE ULCER

Pressure ulcer (PU) is a complex and multifactor disease in which the cellular and molecular mechanisms contributing to risk of a delay in healing. An imbalance between pro-oxidant and antioxidant systems has been suggested to be implicated in the physiopathology of PU. Polymorphisms in TNF-α gene are emerging as key determinants of many diseases. The TNF-α (-238 and -308) G/A single-nucleotide ...

L. Khlifi *, H. Graiet, S. Sahli, N. Bouzidi, M. Ben-Hadj-Mohamed, S. Khelil, A. Dandana, A. Garbi, S. Ferchichi and A. Miled

Biochemistry Laboratory CHU Farhat HACHED, Sousse, Tunisia

DOI: 10.13040/IJPSR.0975-8232.7(3).976-83

976-83

2268

654

12.

FORMULATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SODIUM CARBOXY METHYL CELLULOSE AND β CYCLODEXTRIN MEDIATED TERNARY INCLUSION COMPLEXES OF SILYMARIN

The objective of the present investigation was to study the complexation of silymarin, a poorly water soluble herbal drug, with β-cyclodextrin alone and in the presence of sodium carboxymethyl cellulose to evaluate the feasibility of enhancing the solubility and dissolution rate of silymarine. Phase solubility study and kneading method was employed to develop and formulate solid inclusion complex...

Mohammad Javed Ansari

Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdul Aziz University, Al-Kharj, Saudi Arabia

DOI: 10.13040/IJPSR.0975-8232.7(3).984-90

984-90

3754

856

13.

TOXICOLOGICAL CHRACTERIZATION OF BRHANMANJISTHADI KVATHA CURNA (BRH) ON THE BASIS OF TOTAL PROTEIN AND ALBUMIN CONTENT, LIPID PROFILE, LIVER FUNCTION, KIDNEY FUNCTION, SERUM URIC ACID AND ENZYMATIC PROPERTY IN RATS’ PLASMA AFTER CHRONIC ADMINISTRATION

Brhanmanjisthadi Kvatha Curna (BRH) an Ayurvedic preparation, is used as a traditional medicine in filariasis in the northern part of the country. After 45 consecutive days of chronic administration of the BRH preparation in rats its toxicological aspects was studied. In the study the total protein content in the plasma was increased (2.80 %) in BRH treated male rats in comparison to their control...

S. Mohammad Arif, A. Huque *, Md. A. Al. Mamun , S. M. Ahsan Uddin Ahmed and Md. Omar Ali

Department of Pharmacy, East West University, Aftabnagar, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.7(3).991-04

991-04

2085

557

14.

ANTIBIOGRAM OF PATHOGENIC BACTERIA ISOLATED FROM PRE- AND POST-SURGERY VESICOVAGINAL FISTULA (VVF) PATIENTS IN ABAKALIKI, EBONYI STATE

Vesicovaginal fistula (VVF) is an abnormal fistulous tract that extends between the bladder and the vagina - thus allowing the continuous involuntary discharge of urine into the vaginal vault of the affected patient. This study evaluated presumptively the prevalence and antibiogram of pathogenic bacteria isolated from pre- and post-surgery VVF patients. Urine samples were collected in duplicates f...

I. R. Iroha , F. N. Okafor-Alu , E. N.Ugbo , C. P. Ejikeugwu *, A. C. Nwuzo, A. E. Nwakeze , I. B. Moses , E. Egwu , and G. N. Nwibo

Department of Applied Microbiology, Faculty of Sciences, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria

DOI: 10.13040/IJPSR.0975-8232.7(3).1005-11

1005-11

2422

668

15.

A PILOT STUDY TO ASSESS THE EFFICACY AND SIDE EFFECTS OF SILYMARIN ALONE AND IN COMBINATION WITH ALENDRONATE IN TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS

Background: Currently oral bisphosphonates such as alendronate are the preferred therapeutic option for the treatment of postmenopausal osteoporosis by increasing bone mineral density and decreasing both vertebral and non-vertebral fracture risk. Silymarin is mainly used as hepato-protectant but in recent studies on ovariectomized rats, it was found that silymarin can be a promising antiosteoporot...

M.H El-Hamamsy, H.G. Eltoukhy * and M.M. Hasanein

Department of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(3).1012-20

1012-20

2184

654

16.

IN VITRO ANTIOXIDANT ACTIVITIES AND CYTOTOXICITY STUDY OF THE METHANOLIC EXTRACT OF BARKS OF SYZYGIUM CYMOSUM

The aim of the study to determine antioxidant and cytotoxic properties of the bark extracts of Syzygium cymosum along with phytochemical study for the presence of phytochemical constituents. Total phenolic and flavonoid content of the S.Cymosum   extracts was determined by using the Folin- Ciocalteu reagent and aluminum chloride (AlCl3) method, respectively. The crude methanolic extract of S.Cym...

Kakan Sutra Dhar, Tania Binte Wahed *, A. H. M. Nazmul Hasan and Sonia Binte Wahed

Department of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.7(3).1021-25

1021-25

2080

663

17.

SPECTROFLUORIMETRIC STUDY ON THE INTERACTION OF IOSARTAN POTASSIUM AND BOVINE SERUM ALBUMIN

The interaction of losartan potassium (LP) with bovine serum albumin (BSA) was studied by fluorescence quenching in combination with UV–Vis spectroscopic method under near physiological conditions. The fluorescence quenching rate constants and binding constants for BSA–LP system were determined at different temperatures. The fluorescence quenching of BSA by LP is due to static quenching and en...

Mingyan Sun, Ming Su and Hanwen Sun*

College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding, PR China

DOI: 10.13040/IJPSR.0975-8232.7(3).1026-34

1026-34

2843

649

18.

SUBSTANTIATION OF THE PRESERVATIVE IN THE COMPOSITION OF THE IMMUNOBIOLOGICAL DRUG “CANDIDOCYDE”

Over the last decade the incidence of candidiasis has dramatically increased. To fight candidal infections vaccines with immune modulating properties have been actively investigating in recent years. In our previous studies it was found that the immunobiological drug under the conditional name “Candidocyde” based on the antigens of C. albicans and C. tropicalis fungi possessed the protective a...

М. V. Rybalkin*, N. І. Filimonova, T. V. Diadiun, V. V. Kovalev and Iu. M. Azarenko

Department of Biotechnology 1, Department of Commodity 3, National University of Pharmacy, 4, Valentinovskastr., Kharkiv- 61168, Ukraine

DOI: 10.13040/IJPSR.0975-8232.7(3).1035-38

1035-38

1656

548

19.

THERAPEUTIC AND ECONOMIC BENEFITS OF A CENTRALIZED UNIT FOR CYTOSTATIC DRUGS PROCESSING

Cancer is a global problem. However, in low-income and developing countries, the expenditures associated with its treatment are increasing disproportionately with resources available. Hence, reducing the drug wastage and financial burden placed on patients, family and society in general is becoming imperative. Our aim was to calculate therapeutic and economic benefits derived by the use of a centr...

Artan Shkoza *, Mirlinda Likmeta, Enida Balla and Ledjan Malaj

Biomedical and Experimental Department, Faculty of Medicine, University of Medicine in Tirana, Albania

DOI: 10.13040/IJPSR.0975-8232.7(3).1039-42

1039-42

2012

574

20.

VITAMIN D INTAKE AND SUN EXPOSURE IN AUTISTIC CHILDREN

It is well known that main sources of Vitamin D are sun exposure and diet. There is a gap in our knowledge about the contribution of these factors to Vitamin D level among autistic children in Egypt. Aim: To determine Vitamin D dietary intake and sun exposure and their impact on vitamin D level. Methods and procedures: Serum Vitamin D levels were measured in 42 autistic and 40 healthy matched chil...

S. F. Fahmy *, N. A. Sabri, M. H. El Hamamsy, M. El Sawi and O. K. Zaki

Faculty of Medicine, Ainshams University Hospitals, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.7(3).1043-49

1043-49

2784

799

21.

AN IN-VIVO COMPARATIVE STUDY OF CERIUM TOXICITY IN BULK FORM AND IN NANOPARTICULATE FORM

Scope: In recent years, governments and industries worldwide have invested billions of dollars in nanotechnology research and development, and proponents predict that it will offer numerous benefits to society. Objectives: To evaluate the toxicity of Cerium in nanomaterials and in bulk form in rats by repeated daily oral treatment for 28 days by monitoring the effects on animal and also to assess ...

Z. Mahveen *, A. Tiruvaipathi, M. F. Rahman and Sara Fatima

Department of Pharmacology, Al Hasnath colony, Tolichowki, Hyderabad, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1050-69

1050-69

2151

704

22.

PHYLOGENETIC ANALYSIS OF RAS SUBFAMILY PROTEINS

Cancer is primarily an environmental disease with 90–95% of cases attributed to environmental conditions and 5–10% due to genetics.RAS proteins act as binary molecular switches and play an important role in intracellular signal transduction which regulates processes such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. The present b...

Diksha Jain, Ravita Rawat and Vinod Kumar Jatav *

Department of Biotechnology, MITS Gwalior, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1070-80

1070-80

1821

536

23.

FORMULATION AND EVALUATION OF GASTRO RETENTIVE MATRIX TABLETS OF ATENOLOL USING MELT GRANULATION TECHNIQUE

The main objective of this present work was to develop and evaluate matrix tablets of Atenolol by melt granulation technique and compare the drug release between bess wax and glyceryl monostearate (GMS). Polymers like HPMC K 4 M, HPMC K 100 M, bees wax, glyceryl monostearate and ethyl cellulose were incorporated in the formulation. Formulations were prepared by keeping the HPMC and ethyl cellulose...

Sarada Anepu *, Lohithasu Duppala , Nikhil J. and Janaki Devi S.

A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1081-92

1081-92

2625

687

24.

ANTIBACTERIAL ACTIVITY OF DIFFERENT EXTRACTS OF TRICHOSANTHES CUCUMERINA L AN ENDANGERED ETHNOMEDICINAL HERB

The present work has been under taken to study the antibacterial activity of stem, leaf, flower and seed extracts of Trichosanthes cucumerina L against disease causing bacteria. Antibacterial activity of different solvent  extracts (Aqueous, Methanol, Chloroform, Petroleum ether, Acetone) of stem, leaf, flower and seed of T. cucumerina has been studied to find out their activity against nine path...

S. Rudroju, K. Gudikandula, S. Talari and R. S. Nanna *

Plant Biotechnology Research Group, Kakatiya University, Warangal (TS), India

DOI: 10.13040/IJPSR.0975-8232.7(3).1093-02

1093-02

2813

868

25.

SYNTHESIS, CHARACTERIZATION, EQUILIBRIUM AND BIOLOGICAL STUDIES OF NOVEL 33-(1-(BENZO[D]THIAZOL-2-YLIMINO)ETHYL)-6-METHYL-2H-PYRAN-2,4(3H)-DIONE AND ITS Cu (II), Ni (II) AND Hg (II)METAL COMPLEXES: AN EXPERIMENTAL AND THEORETICAL APPROACH

The compound 3-(1-(benzo[d]thiazol-2-ylimino) ethyl)-6-methyl-2H-pyran-2, 4(3H)-dione (3BTIEMPD) and its metal complexes were prepared and characterized by spectro-analytical techniques. Irving-Rossetti pH-metric technique was employed to determine the number of dissociable protons and chelation sites of the title compound. Hyper Chem 7.5 software was used to understand donor and acceptor properti...

J. Mohmed, R. R. Palreddy, A. Boinala, N. Narsimha, S. K. Gunda and S. Devi Ch *

Department of Chemistry *, Osmania University, Hyderabad, Telangana State, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1103-15

1103-15

2155

599

26.

FABRICATION AND IN-VITRO EVALUATION OF CEFIXIME NANOPARTICLES USING GUM KONDAGOGU AND CHITOSAN AS MATRIX FORMERS

Cefixime is more effective in treating multi drug resistant typhoid fever but the major limitation was its poor bioavailability with short half- life. The present investigation was attempted to develop a natural polymer based nanoparticles containing cefixime using gum kondagogu and chitosan as polymers for customising the drug release profile to achieve an effective therapeutic concentration by i...

B. Harika, K. Gowthamarajan, D. Chamundeeswari, K. Chitra and S. Shanmuganathan *

Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1116-24

1116-24

2835

620

27.

INHIBITION OF MYCOBACTERIAL GLYCOSYLTRANSFERASES WITH PHYTOCOMPOUNDS- AN IN-SILICO APPROACH

Emergence of Mycobacteria that are resistant to common antibiotics necessitate development of novel antibacterial drugs. The complexity of mycobacterial cell envelope plays an important role in its defense against antimicrobial activity of human immune system. The cell wall of Mycobacteria constitutes a set of carbohydrate-containing molecules. Glycosyltransferases, the glycan processing enzymes p...

Bincy Baby, V. Ravisankar, Lekshmysree S. Nair and P. A. Nazeem *

Bioinformatics Centre, College of Horticulture, Kerala Agricultural University, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1125-30

1125-30

2061

542

28.

FORMULATION DEVELOPMENT AND EVALUATION OF pH TRIGGERED IN SITU OPHTHALMIC GEL OF EPINASTINE HYDROCHLORIDE

The poor bioavailability of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using in situ forming ophthalmic drug delivery system prepared from polymer that exhibit reversible liquid–gel phase transition.  The objective of the study was to develop optimized formulation of  in situ ophthalmic gel of Epinastine hydrochloride, an antihistaminic drug, using a p...

Azmat Shaikh *, Talat Farheen and Sadhana Shahi

Y. B. Chavan College of Pharmacy, Department of Pharmaceutics, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(3).1131-38

1131-38

2640

745

29.

3D-QSAR STUDY OF BENZOTHIAZOLE DERIVATIVES AS p56lck INHIBITORS

3D-QSAR models of Comparative of Molecular Field Analysis (CoMFA) and Comparative of Molecular Similarity Indices Analysis (CoMSIA) of 44 potent p56lck inhibitors were performed. The conventional ligand-based 3D-QSAR studies were performed for a series of Benzothiazole derivatives as p56lck inhibitors. The model gave q2 values of 0.710 and 0.642, r2 values of 0.966 and 0.956 for CoMFA and CoMSIA, ...

Jaheer Mohmed, Shruti Nalikala and Shravan Kumar Gunda *

Division of Bioinformatics, Osmania University, Hyderabad, Telangana State, India.

DOI: 10.13040/IJPSR.0975-8232.7(3).1139-48

1139-48

2043

697

30.

CHONEMORPHA FRAGRANS (MOON) ALSTON – AN EFFECTIVE ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC AGENT IN STREPTOZOTOCIN NICOTINAMIDE INDUCED DIABETIC RATS.

Ethanolic extract of the roots of Chonemorpha fragrans, a traditionally used antidibetic plant was evaluated for its antihyperglycemic and antihyperlipidemic effect using streptozotocin-nicotinamide induced diabetic rat model. Oral glucose tolerance test with 2g/kg of glucose and normoglycemic studies were performed which showed a dose dependant decrease in sugar levels. The acute oral toxicity st...

Bobby S. Prasad *, K. K. Srinivasan and Jyoti Harindran

Department of Pharmaceutical Sciences, M. G. University, Cheruvandoor Campus, Ettumanoor, Kottayam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.7(3).1149-55

1149-55

1826

741

31.

ANTIBACTERIAL ACTIVITY, PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF STEM OF NICOTIANA TABACUM

The parts of the Nicotiana tabacum plant have been known to possess a wide range of biological activities. The purpose of the present study was to investigate the antibacterial activity, phytochemical screening and the antioxidant activity of aqueous and alcoholic extracts of the stem of Nicotiana tabacum. The antibacterial activity was observed against two gram positive bacteria (Bacillus amyloiq...

Y. Sharma, D. Dua, A. Nagar and N. S. Srivastava *

Amity Institute of Biotechnology, Amity University, Uttar Pradesh, India,

DOI: DOI: 10.13040/IJPSR.0975-8232.7(3).1156-67

1156-67

4203

965

32.

PROTECTION OF LOW LET RADIATION-INDUCED DNA DAMAGE IN RAT BONE MARROW CELLS BY FREE RADICAL SCAVENGER CURCUMIN

Antioxidant potentials and radioprotective properties of curcumin were studied. Free radical scavenging activity of curcumin was measured spectrophotometrically using ferric ion reducing power assay, DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical test, hydroxyl radical scavenging activity assay, nitric oxide scavenging assay and superoxide scavenging capacity. The antioxidant properties depend...

Paonam Priyobrata Singh *, Khoirom Ratipiyari Devi, Moirangthem Medhapati Devi, Dhanaraj Singh Thokchom and Gurumayum Jitendra Sharma

Centre of Advanced Study in Life Sciences, Manipur University, Imphal-795003, India.

DOI: 10.13040/IJPSR.0975-8232.7(3).1168-78

1168-78

2192

557

33.

ANTIMICROBIAL ACTIVITIES OF FRESHWATER CYANOBACTERIUM, NOSTOC SP. FROM TAMDIL WETLAND OF MIZORAM, INDIA: AN IDENTIFICATION OF BIOACTIVE COMPOUNDS BY GC-MS

A freshwater microalga, Nostoc sp. isolated from Tamdil Wetland of Mizoram was tested for its algicidal, antibacterial and antifungal activity. Extracts were prepared with methanol, ethanol:water and dichloromethane:isopropanol and tested for their antimicrobial activity against nine microorganisms comprising of three chlorophycean algae (Chlorella vulgaris, Scenedesmus quadricauda and Selenastrum...

Kshetrimayum Mirabai Devi and Surya Kant Mehta*

Department of Botany, Mizoram University, Aizawl, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1179-91

1179-91

2579

752

34.

IN-SITU OPHTHALMIC GEL FORMING SOLUTION OF MOXIFLOXACIN HYDROCHLORIDE FOR SUSTAINED OCULAR DELIVERY

Human eye is a challenging subject for topical administration of the drugs because of its peculiar anatomical arrangements of surface tissue and impermeability of the cornea. Topical instillation of drugs through eye drops is the most important and well-accepted route of administration for the treatment of various eye disorders. Conventional ophthalmic drug delivery systems often result in poor bi...

S. Sawarkar, P. Ravikumar and S. Pashte

Department of Pharmaceutics, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle, Mumbai-400056, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1192-05

1192-05

4268

789

35.

VITAMIN E AMELIORATE THE LIPIDS PROBLEM INDUCES BY CONTRACEPTIVES

Women on different contraceptive methods have been linked with the development of various changes in lipids profile. Therefore, the relationship between contraceptive use and lipids changes needs to be investigated. Method: This was a cross-sectional randomized study conducted on non-lactating, non-pregnant women who were on different methods of contraceptives for at least a period of 6 months and...

Saif M. Hassan *, Mohammed A. Ejerish and Usama Herba

Al-shomaly hospital, Babylon Health Director, Ministry of Health, Babylon, Iraq

DOI: 10.13040/IJPSR.0975-8232.7(3).1206-10

1206-10

1844

726

36.

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR DETERMINATION OF MICAFUNGIN AND ITS RELATED SUBSTANCES IN BULK BY RP-UPLC

A gradient reverse phase Ultra Performance Liquid Chromatographic (RP-UPLC) method was developed and validated for determination of Micafungin sodium and its synthetic impurities. The successful separation of Micafungin sodium and its synthetic impurities was achieved using Phenomenax Aeris peptide XB C18 (150×2.1 mm i.d., 1.7 µ particle size) column maintained at 45 °C temperature with mobile ...

Smita Joshi *, Falguni Majmudar and Nirav Vyas

Department of Pharmaceutical Chemistry, K. B. Raval College of Pharmacy, Gandhinagar, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1211-18

1211-18

3172

1081

37.

ANTIOXIDANT ACTIVITY OF AQUEOUS SEED EXTRACT OF ANETHUM GRAVEOLENS L.

To provide a scientific basis to traditional uses of seeds of Anethum graveolens, seed extract was evaluated for its antioxidative potential. Firstly, indeed, aqueous extract of Anethum graveolens was prepared and analyzed for the phytochemical compounds contents. Furthermore, antioxidant activity was assessed using the Total Antioxidant Capacity (TAC) methods: 2.2’Azinobis (3-ethylbenzthiazolin...

El M. Latifa *, B. Dalila, B. Mounyr , O. Wessal and Elyoubi-El H. Amal

Lpamsn , National Institute of Medicinal and Aromatic Plants, Sidi Mohamed Ben Abdellah University (USMBA), Fez, Morocco

DOI: 10.13040/IJPSR.0975-8232.7(3).1219-23

1219-23

2327

599

38.

IN VITRO ANTIOXIDANT ACTIVITY OF FRUITS OF HUGONIA MYSTAX L. (LINACEAE)

The plant Hugonia mystax L., is a woody evergreen liana belonging to the family Linaceae, locally knows as Modirakanni. Ethnobotanically the tender fruits were used for rheumatism and biological activities like antimicrobial were reported. Present study find outs the scientifically evidence of fruits of Hugonia mystax for its antioxidant property. The different extract of fruits was obtained by su...

A. Vimalavady * and K. Kadavul

Department of Plant Science, Tagore Arts College, Lawspet, Puducherry, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1224-28

1224-28

1794

682

39.

ENHANCEMENT OF BIOAVAILABILITY OF NORFLOXACIN MUCOADHESIVE SUSPENSION BY USING DIFFERENT GRADES OF CARBOPOL

Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone.   Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability an...

Nisha Sharma * and Kalpana

University Institute of Pharmacy, C.S.J.M. University, Kalyanpur, Kanpur, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1229-34

1229-34

1912

491

40.

ANTIFERTILITY ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF SEMECARPUS ANACARDIUM FRUIT IN FEMALE ALBINO RATS

Semecarpus  anacardium plant derivatives has been used since antiquity, The fruit and nut extract of Semecarpus anacardium shows various activities like antiatherogenic, anti-inflammatory, antioxidant, antimicrobial, antireproductive, CNS stimulant, hypoglycemic, anticarcinogenic, antifertlity effects. The present study is an attempt to explore the antiovulatory effect of aqueous and ethanolic ex...

Y. Sushma *, Gajanana Kulkarni and Shilender Singh

Department of Pharmacology , Subbhaiah Institute of Medical Sciences and Research Centre, Shivamogga, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1235-39

1235-39

1959

648

41.

WOUND HEALING ACTIVITY OF AQUEOUS EXTRACT OF LEPTADENIA RETICULATA IN WISTAR ALBINO RATS

Herbal medicines have been widely utilized as effective remedies for the prevention and treatment of multiple health conditions for centuries by almost every known culture. Leptadenia reticulata belonging to the family Asclepiadaceae is an important medicinal plant which is used for various ailments. In the present study, an attempt was made to study the wound healing activity of aqueous extract o...

B. Sneha*, M. Ganga Raju and Veeresh Babu

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(3).1240-44

1240-44

2056

573

42.

EVALUATION OF THE CHEMICAL CONSTITUENTS AND THE ANTIBACTERIAL ACTIVITY OF ESSENTIAL OIL OF CITRUS KARNA FRUIT PEEL

The present study was concerned with analysis of the chemical constituents of essential oil of Citrus karna fruit peels by GC-MS technique and also its antibacterial activity against some pathogenic bacteria. The essential oil was extracted from fruit peels by steam distillation using Clevenger’s type apparatus. GC-MS analysis of essential oil showed presence of D-limonene and β-pinene as the m...

Muhammad Sikander Dar *, Reena Lawrence and Anam Noor Khan

Department of Chemistry, Sam Higginbottom Institute of Agriculture, Technology and Sciences (Formerly AAI-DU), Allahabad, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1245-50

1245-50

2703

712

43.

PREVALENCE OF HYPOTHYROIDISM AND ITS CO-MORBIDITIES IN RELATION TO THE CAUSES AND RISK FACTORS IN PATIENTS UNDERGOING LEVOTHYROXINE THERAPY

Hypothyroidism is a metabolic disorder, which results in slower rate of metabolism leading to life threatening medical conditions like diabetes and other complications. This study aims to analyze the prevalence of hypothyroidism and its co-morbidities in relation to the causes and risk factors in patients undergoing levothyroxine therapy and to know the adherence level of prescribers to the Thyroi...

A. Anandhasayanam , T. Arivudainambi , S. Kannan and Sam Johnson Udaya Chander J.*

Department of Pharmacy Practice, RVS College of Pharmaceutical Sciences, Coimbatore, TN, India.

DOI: 10.13040/IJPSR.0975-8232.7(3).1251-57

1251-57

5560

676

44.

ASSESSMENT OF THE DEGREE OF AWARENESS AMONG PHYSICIANS AND PATIENTS ABOUT DRUG PACKAGE INSERTS

The package inserts (PI) are a valuable source of information on drugs for physicians and patients. However, the degree of awareness of PI & their perceptions at both physician and patient front has not been studied in India in current times. The study was undertaken to assess the degree of awareness regarding information in drug package inserts at a tertiary care centre in western India. A qu...

Kanchan Rao Singh *, Renuka Munshi and Danish Arora

Department of Pharmacology , T.N. Medical College and BYL Nair Ch. Hospital, Mumbai Central, Mumbai, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1258-62

1258-62

2116

609

45.

TRADITIONAL PHYTOTHERAPY FOR VARIOUS DISEASES BY THE LOCAL RURAL PEOPLE OF BHARAI VILLAGE IN THE KULLU DISTRICT OF HIMACHAL PRADESH (INDIA)

An ethno-medicinal survey was undertaken in Bharai village of Kullu district in Himachal Pradesh to collect the information on the use of medicinal plants for the various diseases rampant in the area through questionnaire and personal interviews of the traditional health healers/rural people The investigation reveals that 20 plants belonging to the 16 different families are utilized by local healt...

Amit Pandey * and Shweta Singh

University School of Environment Management, Guru Gobind Singh Indraprastha University, Delhi, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1263-70

1263-70

2504

736

46.

IN-SILICO APPROACH FOR THE ASSESSMENT OF ORAL CANCER PROPERTY ON LIMONIA ACIDISSIMA

Cancer is the abandoned growth of cells that invade and cause damage to surrounding tissue. Oral cancer appears as a growth or uncomfortable in the mouth that does not go away. Oral cancer, which includes cancers of the lips, tongue, cheeks, floor of the mouth, hard and soft palate, sinuses, and pharynx (throat). Tabocco and alcohol are recognized as the foremost risk factor for this oral cancer. ...

N. Arun Kumar, R. Sharmila*, K. Akila and B. Jaikumar

PG Research Department of Biotechnology & Bioinformatics, Bishop Heber College (Autonomous), Tiruchirappalli, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1271-75

1271-75

2015

848

47.

A CROSS-SECTIONAL STUDY ON ASSESSING THE KNOWLEDGE, ATTITUDE AND BEHAVIOUR OF COMMUNITY PHARMACISTS TO ADVERSE DRUG REACTIONS RELATED ASPECTS

The adverse drug reaction (ADR) programme in India, targeted all healthcare professionals to report the ADRs, however the response is very limited. The ADR reporting is much concentrated to hospital settings and the community pharmacies are unaware of this change. This study was conducted to assess the attitude, knowledge and behaviour of community pharmacists to ADR related aspects. A prospective...

K. T. Mohammed Salim *, T. Balasubramanian, P. Muhammed Lubab, S. A. Nayana , P. M. Nathaliya and P. Nimsha Hussain

Department of Pharmacy Practice, Al Shifa College of Pharmacy, Perinthalmanna, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1276-85

1276-85

1964

635

48.

PHYSICO-CHEMICAL AND PHARMACOLOGICAL PROSPECTIVE OF ROGHAN-E-NARJEEL (COCONUT OIL)

Roghan-e-Narjeel (coconut oil) is extracted from dried Maghz-e-Narjeel (coconut kernels) which is derived from coconut (Cocosnucifera L.) tree. It is used extensively in tropical countries especially India, Srilanka and Philippines. The oil contains 92% of saturates consisting of medium chain fatty acids in the form of triglycerides containing lauric acid in large amount, and about 8% of unsaturat...

Mohd. Shamim Khan * Qamrul Hasan Lari and Mahmood Ahmad Khan

Government Unani Dispensary, Kota, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1286-91

1286-91

4649

794

49.

A COMPARATIVE CLINICAL STUDY OF INTRATHECAL ROPIVACAINE AND ROPIVACAINE-CLONIDINE COMBINATION FOR LOWER LIMB ORTHOPAEDIC SURGERIES

Ropivacaine is a promising drug for subarachnoid block because of its lower cardiotoxic and neurotoxic potential, but onset and duration of anaesthesia is also low and motor block is often insufficient which may lead to use of its higher doses. The aim of this randomized double-blinded study was to see whether the addition of small dose clonidine to small dose ropivacaine for spinal anesthesia pro...

Swati Srivastava, Urvashi Yadav *, Rakesh Verma, Shagufta Naaz and Dheer Singh

Department of Anaesthesiology .UP Rural Institute of Medical Sciences and Research, Saifai, Etawah (UP) India

DOI: 10.13040/IJPSR.0975-8232.7(3).1292-97

1292-97

2243

656

50.

BIO ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TEMOZOLOMIDE IN RAT PLASMA USING RP-HPLC METHOD

A simple high-performance liquid chromatographic method was developed and validated for the determination of Temozolomide in rat plasma using paracetamol as internal standard.  The chromatographic separation was carried out with an isocratic elution using mobile phase consisting of 0.5% glacial acetic acid and methanol.  Plasma samples were run at a flow-rate of 1 ml/min using a kromasil C18(4.6...

Swathimutyam Pallerla* and Bala Prabhakar

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Vile Parle, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(3).1298-01

1298-01

2410

679

51.

SYNTHESIS, ANTIBACTERIAL AND ANTI- MYCOBACTERIAL ACTIVITY OF SOME NOVEL3-(6-PHENYL-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL-3-YL)-2H-CHROMEN-2-ONE

Several 3, 6-substituted - [1,2,4] Triazolo [3,4-b][1,3,4] Thiadiazole}-2H-Chromen-2-ones(5a-5j) have been synthesized from ethyl-2-oxo-2H-chromene-3-carboxylate (1)  through a multistep reaction sequence. Compound 1 reacted with hydrazine hydrate in the presence of ethanol to give 2-oxo-2H-chromene-3-carbohydrazide (2) which on treatment with carbon disulphide and methanolic potassium hydroxide ...

Bono Naga Sudha * and V. Girija Sastry

Department of Pharmaceutical Chemistry , CES College of Pharmacy, Kurnool, AP, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1302-07

1302-07

1913

617

52.

ISOLATION, IDENTIFICATION AND CHARACTERIZATION OF HEAVY METAL RESISTANT BACTERIA FROM SOIL OF AN IRON INDUSTRY, HARYANA (INDIA).

Metallic contaminants in the soil are hazardous and their accumulation in plants and water may be dangerous. Microorganisms have properties to adsorb, absorb and accumulate heavy metals. Moreover, they play the role of problem solver by resolving key problems associated with different kinds of metals. The study was undertaken to isolate and identify heavy metal resistant bacteria in soil around ir...

Richa Gupta, Tarun Kumar and Amita Mittal*

Department of Biotechnology Engineering, University Institute of Engineering & Technology, Kurukshetra University, Kurukshetra, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1308-13

1308-13

6398

1113

53.

EFFECT OF ALOE VERA EXTRACT ON THE HEPATOTOXICITY INDUCED BY ISONIAZID AND RIFAMPICIN DRUG IN MALE WISTAR RATS

Male Wistar rats were procured from ‘The Bombay Veterinary College’, Parel, Mumbai. The animals were maintained and housed in cages and were acclimatized in laboratory conditions for ten days prior to the experiment. The experimental rats were fed orally with isoniazid 300 mg/ 70 kg body weight / day; rifampicin 450 mg / 70 kg body weight / day and Aloe vera extract 50 mg/ kg body weight / day...

G. V. Zodape * and P. P. Bhise

Departments of Zoology, Shivaji University, Kolhapur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1314-20

1314-20

3091

642

54.

HIGH THROUGHPUT LC-MS/MSMETHOD FOR THE QUANTITATION OF LINAGLIPTIN IN HUMAN PLASMA BY SOLID PHASE EXTRACTION USING 96 WELL PLATE FORMAT

High-throughput Liquid chromatography–mass spectrometry method has been developed and validated for the quantification of Linagliptin in human plasma using Linagliptin D4 as an internal standard (ISTD). Following solid phase extraction (SPE) in 96 well plate format, the analyte and ISTD were run on  phenyl hexyl, 100A 100 X 4.6mm, 2.6µusing an isocratic mobile phase consisting of 10mM Ammoniu...

Tangudu Nagabhusana Rao*, Guntuku Girija Sankar and Lade Jyothi Rani

Sr. Scientist II Nektar Therapeutics (India) Pvt Ltd. Sy Nos. 101/2, Genome Valley, Lalgadi Malakpet, Shameerpet Mandal, Hyderabad, R.R. District, Telangana - 500078, India

DOI: 10.13040/IJPSR.0975-8232.7(3).1321-30

1321-30

2645

764

55.

TERMINALIA PANICULATA BARK EXTRACT FOR ANTIDIABETIC ACTIVITY

Terminalia paniculata Roth. (TP) is a tropical tree. Traditionally, flower juice and bark of Terminalia paniculata have been used as a remedy for cholera, for the treatment of diabetes, inflamed parotid glands and in menstrual disorders. The objective of the present study is to evaluate the antidiabetic potential of Terminalia paniculata bark extract in various in-vitro models and its safety evalu...

R. Srinivasan *, U. M. Dhanalekshmi , T. Gowri , S. Duarah

Bio Organic Division, Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai, Tamil nadu, India.

DOI: 10.13040/IJPSR.0975-8232.7(3).1331-37

1331-37

2265

688

56.

IDENTIFICATION AND QUANTIFICATION OF AN UNKNOWN PEAK IN RESIDUAL SOLVENT ANALYSIS BY GC USING RELATIVE RESPONSE FACTOR

Organic solvents are integral part of chemical synthesis in pharmaceutical industry. These are commonly used as reaction media, in separation, purification of synthetic products and also for cleaning of equipment. Some of the solvents degrade to other solvents or unknown impurity either during synthesis or in analytical conditions. In this study, we have investigated formation of a trace level imp...

A. A. Deshpande *, B. Sirisha, G. R. Deshpande, J. Moses Babu, R. Murali Krishna and I. M. Rao b

Analytical Research, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd., Hyderabad, (AP), India

DOI: 10.13040/IJPSR.0975-8232.7(3).1343-52

1343-52

9314

1355

57.

MOLECULAR DOCKING STUDIES OF SOME NOVEL HYBRID TETRAOXAQUINES & DISPIROTETRAOXANES AS ANTIMALARIAL AGENTS

In the present study, total fifteen compounds of 1,2,4,5-tetraoxane derivatives were docked. Two series of 1,2,4,5-tetraoxane derivatives were taken for molecular docking studies, one tetraoxaquines, a hybrid of two pharmacophores such as 4-aminoquinoline & 1,2,4,5-tetraoxane, and other dispirotetraoxanes. The docking studies were performed into the binding pocket of a falcipain-3 protein (pdb...

Kumawat Mukesh Kumar * and Chetia Dipak

Department of Pharmaceutical Sciences , Dibrugarh University, Dibrugarh, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.7(3).1348-59

1348-59

2737

786