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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 7 (2016) - Issue 4, April

Review Articles

 
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1.

NANO TECHNICAL TRENDS FOR CANCER TREATMENT: QUANTUM DOTs A SMART DRUG DELIVERY SYSTEM

Conventional chemotherapy drugs show lack of specificity, including reduced activity on cancer treatment with higher toxicity to normal cells and develop resistance after prolonged period of administration. Recently, to nullify all adverse effects of cancer chemotherapy nanometer sized carriers came into role for total cure.  The advanced research community is focused on smart drug delivery syste...

Preet Amol Singh and Neha Bajwa *

Department of Pharmaceutics, I.S.F.College of Pharmacy, Moga, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1360-74

1360-74

4226

1092

2.

REVIEW ON 2-SUBSTITUTED BENZOTHIAZOLES: DIVERSITY OF SYNTHETIC METHODS AND BIOLOGICAL ACTIVITIES

In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties. Benzothiazole is a privileged bicyclic ring system with diverse applications. The small and simple benzothiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess biological activities, such as...

G. Achaiah *, N. Sridhar Goud, K. Praveen Kumar and P. Mayuri

University College of Pharmaceutical Sciences (UCPSC), Kakatiya University, Warangal, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1375-82

1375-82

3932

1610

3.

THERAPEUTIC POTENTIALS OF COW DERIVED PRODUCTS- A REVIEW

Kamdhenu or Indian cow (Bos indicus) is worshipped as sacred animal by Hindus. The reason for worshipping is the tremendous therapeutic values of cow derived products like cow milk, cow milk curd, cow butter (ghee), cow urine, cow dung and a combination formulation Panchgavya. The use of these products has been well defined in ancient Ayurvedic texts like Charak samhita, Shushruta samhita, Brahad-...

R. Kaushik *, J. Jain and P. Rai

Department of Pharmacy, Ram-Eesh Institute of Vocational and Technical Education, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1383-90

1383-90

5087

1117

4.

THE ROLE OF LAB-ON-A-CHIP DEVICE IN HEALTH CARE

Lab-on-a-chip (LOC), a scaled down microfluidic device for carrying out laboratory operations outside the scope of standard laboratories is a rather appealing development in the field of science and technology for the whole laboratory has been reduced to a small chip capable of carrying out various functions. Keeping to its word, micro, miniaturized volume samples and reagents has ebbed the time t...

Sweta Patel, Aishaani Maheshwari and Amrish Chandra*

Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1391-95

1391-95

2904

825

Research Articles

 
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5.

CHEMICAL CHARACTERIZATION AND EVALUATION OF ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTICOAGULANT ACTIVITY OF AQUEOUS EXTRACT AND ORGANIC FRACTIONS OF THYMUS ZYGIS L. SUB SP. GRACILIS

This study was undertaken to evaluate the antioxidant, anti-inflammatory and anticoagulant activities of aqueous extract and organic fractions of Thymus zygis. Water, dichloromethane, ethyl acetate and methanol were used as extractant solvents. The fractions were analyzed by HPLC and screened for their antioxidant activity in vitro using different assay. In vivo, the fractions were evaluated by us...

T. Khouya *, M. Ramchoun , A. Hmidani, S. Amrani, H. Harnafi, M. Benlyas, Y. F. Zegzouti and C. Alem

Department of Biology, Faculty of Sciences & Techniques, University Moulay Ismail, Errachidia, Morocco.

DOI: 10.13040/IJPSR.0975-8232.7(4).1396-05

1396-05

2733

891

6.

EVALUATION OF MIXTURES OF AQUEOUS EXTRACT OF PSEUDOCEDRELA KOTSCHYI AND BOSWELLIA DALZEILII AS INTERACTING PRODUCTS IN REGULATION OF PHAGOCYTOSIS AND LYMPHOCYTES PROLIFERATION

The current study aimed to test the effect of the aqueous extract of Boswellia dalzeilii and Pseudecedrela kotschyi using three different mixing ratios (B. dalzeilii:P. kotschyi) 3:1, 2:2, and 1:3. The assays concerned the study of the interactions in the modulation of phagocytic index, nitric oxide production, lysosomal enzymes and myeloperoxydase activity in macrophages and regulation of lymphoc...

Oumar Mahamat *, Tume Christopher, Kamtchueng Monique Odette and Kamanyi Albert

Department of Biological Sciences, Faculty of Science, University of Bamenda, Cameroon

DOI: 10.13040/IJPSR.0975-8232.7(4).1406-12

1406-12

2151

748

7.

METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD FOR ANALYSIS OF LOSARTAN POTASSIUM IN BULK DRUG AND DOSAGE FORM FORMULATION

Losartan potassium in tablet dosage form, separation achieved with C 18 column (Kromasil 100-5C18250mm x4.6mm E82860   i.d., 5µm particle), ambient temperature with isocratic mode with mobile phase containing 40:60 Acetonitrile:  Buffer consist of 10.5mM of disodium hydrogen phosphate and 10mM potassium dihydrogen phosphate, pH 3.5 adjusted by 10 % Orthophosphoric acid and at flow rate 1.0ml/m...

Elsadig H. Rudwan *, Amna B. W. E Mohammed Hussien and Ahmed E. M. Saeed

Amipharma Laboratories Ltd., Khartoum, Sudan

DOI: 10.13040/IJPSR.0975-8232.7(4).1413-21

1413-21

3777

932

8.

EFFECT OF RAMADAN FASTING AND LIFE HABITS ON THE ANTIPYRINE TEST, URINE VOLUME AND pH

The purpose of this study was to investigate the effects of the Ramadan fasting and life rhythm eating rhythm on some elimination parameters, such as the antipyrine clearance, urinary volume and pH.  A single oral dose of Antipyrine was administred to 14 healthy volunteers at 08:00 p.m. All the volunteers were submitted to four treatment phases; the first one was carried out 1 week prior to Ramad...

N. Aadil *, K. Benyassine , B. Benaji and Y. Benchekroun

Laboratory of Pharmacology, Faculty of Sciences Ain Chock. Hassan II University of Casablanca. Route d’El jadida. BP 5366, Casablanca, Morocco

DOI: 10.13040/IJPSR.0975-8232.7(4).1422-29

1422-29

3073

663

9.

PHARMACOKINETICS AND PHARMACODYNAMICS OF PRIMAQUINE TO PATIENTS WITH UNCOMPLICATED FALCIPARUM MALARIA IN HALMAHERA INDONESIA

Malaria remains one of deadly diseases in Indonesia which mainly occurred in Tobelo, North Halmahera. Genetic factor is one of significant factors where the gene acting in protein and enzyme coding influences the drug pharmacokinetics. However, no studies have been carried out on the pharmacokinetics of anti-malaria of primaquine in Indonesia. The purpose of this research is to know the kinetic pr...

A. L. Mapanawang*, Mustofa, M. A. Wijayanti, R. Handayani, Y. Mogi, F. Mapanawang, A. Maengkom, S. Mapanawang, F. Sambode, Y. Barani, Panji, Erna, M. Sitanala, Purwanto, P. Maengkom and H. Maenkom

Doctoral Program of Medical and Health Sciences, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia, STIKES, Halmahera Indonesia

DOI: 10.13040/IJPSR.0975-8232.7(4).1430-40

1430-40

2631

857

10.

A CLINICAL STUDY EVALUATING THE EFFECT OF IVABRADINE ON INFLAMMATION IN PATIENTS WITH NON ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROMES

There is a strong association between elevated heart rate (HR), systemic inflammation and atherosclerosis. We assumed that HR lowering by ivabradine might decrease inflammation in patients with non ST-segment elevation acute coronary syndromes (NSTE-ACS). Objective: Study the effects of ivabradine add on treatment on High sensitivity C-reactive protein (hsCRP) levels in patients with NSTE-ACS. Met...

M. Adel *, S. Mansour, N. A. Sabri, O. A. Badary and M. Ayman Saleh

Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Egypt.

DOI: 10.13040/IJPSR.0975-8232.7(4).1441-49

1441-49

2567

592

11.

VIRTUAL SCREENING OF COFORMERS FOR ATORVASTATIN Co-CRYSTALLIZATION AND THE CHARACTERIZATIONS OF THE Co-CRYSTALS

Atorvastatin calcium (ATC) is very slightly soluble in water and it is classified under BCS class II drugs. A widely used method to enhance the solubility of drugs is co-crystallization. In this work, we screened six co-formers for ATC by employing molecular docking method. The work was continued by co-crystallization process using slurry method, solubility assay of the mixtures using HPLC, and ch...

D. Gozali , S. Megantara , J. Levita *, H.H. Bahti, S.N. Soewandhi and M. Abdassah

Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor Sumedang, Indonesia

DOI: 10.13040/IJPSR.0975-8232.7(4).1450-55

1450-55

2658

898

12.

ACUTE ORAL TOXICITY STUDY OF AQUILARIA CRASSNA AND α-TOCOPHEROL IN MICE

The combination of agarwood (Aquilaria crassna) young leave with α-tocopherol (α-TOH) showed a synergistic effect which helps to protect the food from lipid oxidation. The present study was designed to elucidate the acute toxicity of the mixture of A. crassna young leaves crude ethanolic extract (CE) and α-TOH on Balb/c mice. This acute oral toxicity study was carried out based on OECD 423 guid...

Sheah Yee Ghan, Jin Han Chin, Yin Yin Thoo, Hip Seng Yim and Chun Wai Ho*

Department of Food Science and Nutrition 1, Faculty of Applied Sciences, UCSI University, No. 1, Jalan Menara Gading, UCSI Heights, Cheras, Kuala Lumpur, Malaysia

DOI: 10.13040/IJPSR.0975-8232.7(4).1456-61

1456-61

3452

696

13.

SYNTHESIS AND CHARACTERIZATION OF NOVEL CHOLESTERYL LACTATE BASED FATTY ACID ANALOGS AND THEIR IN VITRO ANTIMICROBIAL ACTIVITY

A series of novel cholesteryl lactate-fatty acid conjugates (4a-i) were prepared by esterification of cholesterol with lactic acid, followed by coupling hydroxyl group of cholesteryl lactate with –COOH group of fatty acids including, saturated fatty acids of varying carbon chain of C10-C18, unsaturated fatty acids like 10-undecenoic, oleic ((9Z)-octadec-9-enoic), ricinoleic ((9Z,12R)-12-hydroxyo...

Yasa SR, Vijayalakshmi P, Yedla P and Chityal GK

Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1462-70

1462-70

1859

499

14.

PREPARATION OF TERMINALIA CHEBULA LOADED CELLULOSE/CHITOSAN COMPOSITE FILMS AND THE EVALUATION OF DRUG RELEASE AND ANTIMICROBIAL CHARACTERISTICS

Diabetic foot ulcer (DFU) is one of the major problems encountered by nearly 15 % of diabetic patients. Combinations of different antibiotics are used to treat the infection which makes the microorganism multi drug resistant. Among various types of drug delivery system, transdermal drug delivery is preferred in treating DFU because it delivers the drug directly to the wound site, which increases t...

K. Saranya , A. Jeevika and D. Ravi Shankaran *

Nano-Bio Materials and Sensors Laboratory, PSG Institute of Advanced Studies, Coimbatore, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1471-79

1471-79

2110

710

15.

THERAPEUTIC POTENTIAL OF NOVEL HETEROCYCLIC THIAZOLIDINE COMPOUNDS AGAINST HUMAN LYMPHATIC FILARIAL PARASITE: AN IN VITRO STUDY

Objective: Following World Health Organization tropical disease research mandate, there is definitive need for search of new lead molecules for development of drug against human lymphatic filariasis. Thiazolidineone derivatives has shown versatile therapeutic potential. The present study has been undertaken to explore the possible antifilarial effect of such synthetic compounds against filarial pa...

A. Mandvikar, S.V. Hande , P. Yeole , K. Goswami * and M. V. R. Reddy

Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1480-92

1480-92

1699

485

16.

DEVELOPMENT AND VALIDATION OF SIMPLE EFFECTIVE HPLC METHOD FOR THE QUANTITATIVE DETERMINATION OF RELATED SUBSTANCE PRESENT IN SITAGLIPTIN PHOSPHATE DRUG SUBSTANCE

An efficient and sensitive RPHPLC method was developed and validated for the estimation of Sitagliptin Phosphate process impurities in drug substances which were identified and characterized by LCMS, FTIR, 1H NMR, C NMR techniques. The method was carried out on a Symmetry shield RP 18 column at 25°C using a 1 % Perchloric acid and acetonitrile in gradient mode of pump. The flow rate is 1.2 ml/min...

Meher Vijay Dalawai *, Paul Douglas Sanasi and Hemant Kumar Sharma

Aurobindo Pharma Limited Research Centre-II, Indrakaran village, Sangareddy Mandal, Medak district, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1493-02

1493-02

3212

845

17.

DOSE OPTIMIZATION OF CEFTRIAXONE-SULBACTAM COMBINATION IN PEDIATRIC USING IN-VITRO SYSTEMS AND STOCHASTIC SIMULATIONS APPROACHES

Increase in complexity and cost associated with pediatric safety and efficacy studies have reduced the interest of pharmaceutical companies to study bio-therapeutics in pediatric population. Dose recommendations are being made as per patient body weight or body surface area, with the assumption of linearity in body size dose adjustments. In the present study, newer approach i.e. flat fixed age-bas...

Vishnu Dutt Sharma, Aman Singla, Manu Chaudhary and Manish Taneja*

Venus Medicine Research Centre, Hill Top Estate, Bhatoli Kalan, H.P., India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1503-12

1503-12

7848

769

18.

STABLE FORMULATION OF ACECLOFENAC AND THIOCOLCHICOSIDE TABLETS

The present study relates to the stable fixed dose combination comprising of Aceclofenac as a glycolic acid ester of Diclofenac is having analgesic and anti-inflammatory action and Thiocolchicoside, as a glycosulfurated analogue of colchicine which is well known centrally acting muscle relaxant in unit dosage form and to the preparation method thereof. Aceclofenac is very susceptible to decomposit...

V Sai Shivram, Swapnil Deshmukh*, Vishal Dalavi and Dipak Sonawane

Research and Development Department, Tulip Lab Pvt Ltd., Ranjangaon, Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1513-23

1513-23

4214

1223

19.

SYNTHESIS, CHARACTERIZATION OF NOVEL MIXED METAL TARTRATEC OMPLEXES AND STUDY OF THEIR IN VITRO ANTIMICROBIAL ACTIVITY

A series of six new mixed metal complexes of general formulation [MM12(L)n]xH2O, where M= Mn, Co, Ni, Cu, Zn, Cd,M1=Fe,  L= Tartrate ligand, x=1,5,6 and n = 3, are synthesized using tartrate as a bidented ligand. The newly synthesized complexes were characterized using various analytical techniques such as IR, XRD, TGA, Elemental analysis, magnetic susceptibility study etc. IR spectral data sugge...

C. S. Patil *, N. S. Dhavale , V. B. Tadke and R. P. Pawar

Department of Chemistry, Deogiri College, Aurangabad, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1524-34

1524-34

2039

626

20.

GERMINATION OF FENUGREEK SEEDS IMPROVES HYPOGLYCAEMIC EFFECTS AND NORMALIZES INSULIN SIGNILLING PATHWAY EFFICIENTLY IN DIABETES

Recent reports show that germination process increases the hypoglycemic activity of seeds many fold, and can act in a better way for diabetes management. Despite large use of fenugreek seeds than any part of the plant for the treatment of broad range of maladies including diabetes, the anti-diabetic effects of germinated seeds have not been assessed. In the present study, the effect of 21 days ora...

Omi Laila, Imtiyaz Murtaza*, M Z Abdin and Sageera Showkat

Biochemistry and Molecular Biotechnology Laboratory, SKUAST-K, Shalimar Campus, Srinagar, Jammu and Kashmir, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1535-46

1535-46

3164

735

21.

COMPARISON OF ANTIHELMINTHIC ACTIVITY BETWEEN BISARYL BENZYL PIPERAZINE AND BENZIMIDAZOLE LINKED PIPERAZINE DERIVATIVES

Helminthes infections are more common in poor countries where people suffer from poor health hygiene and sanitation, though there are lot of marketed drugs available for these disease but the interesting thing about antihelminthics is that they are either pypirazine or benzimidazole derivatives, so as medicinal chemist the attention will be drawn towards these different moieties which exert same b...

B. Shrestha , J. Banerjee *, P. K. Yadav, A. K. Gupta, H. Khanal

Department of Pharmacy, Sunsari Technical College, Dharan Nepal.

DOI: 10.13040/IJPSR.0975-8232.7(4).1547-55

1547-55

2276

501

22.

QUANTIFICATION OF β-SITOSTEROL FROM FIELD GROWN PLANTS AND CALLUS OF CRATAEVA TAPIA L.

Crataeva tapia L. (Family- Capparaceae) is an important medicinal tree, commonly called as ‘Varuna’. The plant has been reported to possess several medicinal properties. Propagation of Crataeva tapia L. is mostly by seeds, but germination percentage is very low mainly due to presence of hard seed coat. Conservation and propagation of species using biotechnological tools like plant tissue cultu...

Priyanka Sharma*, Avinash Patil and Darshana Patil

Department of Botany 1 Birla College, Kalyan, Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1556-63

1556-63

2664

584

23.

PHYTOCHEMICAL, PHARMACOLOGICAL EVALUATION OF SAPINDUS EMARGINATUS VAHL. BARK EXTRACT FOR NEPHROPROTECTIVE ACTIVITY

Gentamicin causes kidney cellular damage by alterations in biological functions. This study evaluated the nephroprotective potential of the ethanolic extract and its fraction originating from Sapindus emarginatus Vahl. (Sapindaceae) bark against the Gentamicin - induced nephrotoxicity in rat. Objective: To evaluate the nephroprotective effect of ethanol extract and its organic solvent fraction of ...

H. D. Jedage * and K. P. Manjunath

Department of Pharmacognosy, K.L.E. University, College of Pharmacy, Vidyanagar, Hubli, (Karnataka) India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1564-71

1564-71

1808

678

24.

FORMULATION, OPTIMIZATION & EVALUATION OF TRANSDERMAL PATCHES OF SALBUTAMOL SULPHATE

Aim: The objective of the present research work was to formulate and compare two different kinds of penetration enhancer in transdermal patch with placebo patch using a drug (Salbutamol sulphate) and compare for in vitro drug release. Study Design: The transdermal patches of Salbutamol sulphate were prepared by solvent evaporation technique using different ratios of Hydroxy propyl methylcellulose ...

Rakesh Kumar*, Nidhi Saini and Kamal Saroha

Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1572-79

1572-79

2942

658

25.

A NOVEL ASSAY METHOD OF 1-DEOXY NOJIRIMYCINE (DNJ) BY ION CHROMATOGRAPHY

A novel Assay method for the determinationof1-Deoxy nojirimycine(DNJ) was proposed by the authors using ion chromatography. The method was found to be accurate, simple and precise. A method precision RSD of 0.5%, RSD for intermediate precision of 0.6% and correlation coefficient was found to be 0.9999. A recovery of 99.7 to 100.1% at 50%, 100% and 150% levels was found. The DNJ solutions and mobil...

Nagaraju Rajana*, Rubia Lasker, Venkatesh P, Kaviraj Yarbagi, Balakumaran K and J. Moses Babu

Analytical Research, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd., Bollaram road, Miyapur, Hyderabad (TS), India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1580-89

1580-89

2715

937

26.

SWELLABLE AND FLOATING GASTRORETENTIVE FORMULATION FOR SUSTAINED DELIVERY OF METFORMIN HCL

Metformin HCl (MH), is an oral anti-diabetic drug with less bioavailability, and a BCS class III, short plasma half-life as well as narrow absorption window. The objective of this research work is to obtain better delivery of MH to the upper part of GIT by increasing the mean residence time (MRT) in the stomach. For this, Gastroretentive swellable and floating sustained release tablets were prepar...

Sudhir Karna, Vipin Kumar Agrawal, Shashank Chaturvedi*and Mohammad Alim

Department of Pharmaceutics, Invertis Institute of Pharmacy, Invertis University, Bareilly, U.P., India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1590-02

1590-02

2982

643

27.

ANTICANCER ACTIVITY OF AN ETHANOL EXTRACT OF COLEUS FORSKOHLII ROOT AGAINST GASTRIC CANCER CELLS IN-VITRO

Coleus forskohlii is an Indian medicinal plant it treat various diseases of cardiovascular, respiratory, gastrointestinal, and central nervous systems. The purpose of this study was to investigate the anticancer activity of an ethanol extract of Coleus forskohlii against gastric cancer in AGS cancer cell lines. Gastric carcinoma cells were tested in vitro for cytotoxicity, Ao/EtBr staining for apo...

Krishnamoorthy Rajkumar and Ramaswamy Malathi *

PG and Research Department of Biotechnology , Sri Vinayaga College of Arts and Science, Ulundurpet, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1603-11

1603-11

2000

585

28.

SULFONIC ACID COUNTER IONS QUANTIFICATION IN PHARMACEUTICALS BY ION CHROMATOGRAPHY

The present paper deals with the analysis of methane sulfonic acid, benzene sulfonic acid and camphor sulfonic acid counter anions in pharmaceutical ingredients (doxazosin mesylate, amlodipine besylate and clopidogrel camphor sulfonate) by suppressed conductivity anion chromatography. The diluent used for the preparation of sample solution was Milli-Q Water and injected into a standard chromatogra...

K. Yarbagi *, B.Srikanth, Venkatesh Pilli, J. Moses Babu, B. Venkateswara Rao and Paul Douglas

Analytical Research, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd., Bollaram road, Miyapur, Hyderabad-500049 (AP), India

DOI: 10.13040/IJPSR.0975-8232.7(4).1612-19

1612-19

4136

806

29.

PRODUCTION AND CHARACTERIZATION OF L-GLUTAMINASE BY BACILLUS SP.

L-Glutaminase (EC.3.5.1.2) is an amidohydrolase which catalyses the hydrolytical deamination of L-glutamine resulting in the production of L-glutamic acid and ammonia. L-Glutaminase is gaining marked importance due to its application potential in cancer therapy, food industry and of high value chemicals like theronine. A variety of microorganisms, including bacteria, yeast, and filamentous fungi, ...

Swati Sinha and Vinod Kumar Nigam *

Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1620-26

1620-26

4317

1081

30.

EVALUATION OF ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF CROTALARIA BURHIA BUCH.-HAM. ROOTS IN RATS AND MICE

Aim: Present study was aimed to evaluate the analgesic activity of methanolic extract of Crotalaria Burhia roots (Henceforth, MECB) using various experimental animal model of pain. Materials & Methods: Analgesic activity was tested using acetic-acid induced writhing test, formalin test, hot-plate test and tail-flick test for pain in mice and rats. In this study we investigated analgesic activi...

Bhavesh M. Vyas , Monika S. Malli , Prafulkumar A. Talaviya * and Sneha V. Ghadiya

Department of Pharmacology, AMC-MET Medical College, Ahmedabad, Gujrat, India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1627-32

1627-32

2163

677

31.

SYNTHESIS, CHARACTERIZATION, AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL HYDRAZONE DERIVATIVES DERIVED FROM 3-((4-FORMYL-2-METHOXYPHENOXY) METHYL) BENZONITRILE

Hydrazones are an important classe of biologically active compounds found in many synthetic compounds. In view of their importance in synthetic chemistry, the present article reported that a new series of novel hydrazone derivatives (4a-e) were synthesized by condensation of 3-((4-formyl-2-methoxyphenoxy)methyl)benzonitrile(3) with different benzohydrazides and confirmed by their IR, 1H NMR, and M...

Kantlam Chamakuri , Srinivasa Murthy Muppavarapu * and Narsimha Reddy Yellu

Department of Pharmaceutical Chemistry, Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, Telangana State, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1633-39

1633-39

2167

619

32.

TRACE AND MAJOR ELEMENTS IN ANTI-UROLITHIATIC MEDICINAL PLANTS

The inhibitory role of trace and major elements in urinary stone crystallization was investigated in five widely used anti-urolithiatic medicinal plants of North East India. Fifteen elements namely K, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se and Br were detected with different concentrations (in ppm level) by Proton Induced X-ray Emission(PIXE) technique while light elements namely F, Na,...

R. K. Bhanisana Devi *, H. Nandakumar Sarma and Sanjiv Kumar

Department of Physics, Manipur University, Canchipur, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1640-44

1640-44

1956

505

33.

STUDY OF THE BINDING PROPERTIES OF GUM OBTAINED FROM CURCUMA AMADA ON MODEL DRUG PARACETAMOL

The aim of the present study is to evaluate the gum of Curcuma amada (mango ginger) as a tablet binder employing paracetamol as a model drug. Natural gums are economic, easily available and found useful as tablet binder. The physicochemical properties of a gum obtained from the rhizomes of Curcuma amada were characterized by Fourier transmittance infra red (FTIR) and Differential scanning colorime...

N. Thakur *, P. Mittal, M. Goswami, R. Kaur, R. Bansal, M. Bansal, and V. Gupta

Chandigarh University, Gharuan, Mohali, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1645-55

1645-55

1812

585

34.

IDENTIFICATION AND QUANTIFICATION OF PHENOLIC COMPOUNDS FROM OPERCULINA TURPETHUM (L.) SILVA MANSO LEAF BY HPLC METHOD

Plants served as potent sources of bioactive compounds since ages. The understanding of phytochemical constitution of each and every plant on earth is the preliminary and the most important step in drug discovery. As Operculina turpethum(L.) Silva Manso is traditionally used for various ailments, the understanding of phytochemical composition of the plant is very essential.  The present study was...

Anju Vijayakumari Jalaj* and Puthuparampil Madhavan Radhamany

Department of Botany, University of Kerala, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1656-61

1656-61

2304

765

35.

RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IMPURITIES FROM EMTRICITABINE AND TENOFOVIR DISOPROXIL FUMARATE TABLET

Stability indicating RP-HPLC gradient method developed for simultaneous determination of impurities and degradation products from Emtricitabine and Tenofovir Disoproxil Fumarate in pharmaceutical tablet dosage form. The chromatographic separation was achieved by using column ACE C18 (250 x 4.6, 5μ). The mobile phase-A consists of 0.01M potassium dihydrogen phosphate buffer with pH 4.0 adjusted us...

Ajay D. Mali* and Uttam B. More*

Department of Chemistry, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1662-69

1662-69

28868

805

36.

QUALITY BY DESIGN APPROACH FOR THE DEVELOPMENT AND VALIDATION OF SAXAGLIPTIN BY RP-HPLC WITH APPLICATION TO FORMULATED FORMS

Quality by Design (QbD) is a philosophy that refines the level of knowledge associated with a product that uses process understanding to deliver a product with the desired critical quality attributes. The objective of this present study was to develop and demonstrate an integrated multivariate approach to develop and quantify the constituent concentrations of saxagliptin drug in its pure and formu...

Shubhangi C. Daswadkar *, Madhumita A. Roy , Sanjay G. Walode and Mahendra Kumar CB

Department of Pharmaceutical Chemistry, Padm. Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1670-77

1670-77

2921

794

37.

FORMULATION AND EVALUATION OF ELASTIC NIOSOMES OF ELETRIPTAN HYDROBROMIDE

Migraine is an episodic headache disorder characterized by a combination of neurological, gastrointestinal, and autonomic symptoms. Eletriptan hydrobromide (EHBr) is a second generation triptan drug intended for treatment of migraine headaches. The main aim of the study was to prepare and evaluate elastic niosomes of EHBr (ENEH) and optimise the concentration of non-ionic surfactants and ethanol b...

M.Shalini, M. M. Husnien Ali and P. K. Lakshmi*

G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1679-85

1679-85

3059

980

38.

SPECTROSCOPIC SIGNATURE, ANTIBACTERIAL AND ANTICANCER PROPERTIES OF CALOTROPIS GIGANTEA (LINN.) FLOWER

Calotropis gigantea L. flowers were widely used as a natural herbal medication. The objective of the present study was to screen the phytoconstituents and to evaluate the antibacterial and anti-cancer properties of Calotropis gigantea flower extract. The UV-Vis and FTIR spectroscopic techniques were employed to screen the phytochemicals. The antibacterial property of the extract was evaluated thro...

K. Gururaja and M. David*

Laboratory of Environmental Toxicology and Molecular Biology, Department of PG studies in Zoology, Karnatak University, Dharwad, Karnataka - 580003, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1686-93

1686-93

2240

507

39.

CHARACTERIZATION OF PHYTOCONSTITUENTS, IN VITRO ANTIOXIDANT ACTIVITY AND PHARMACOLOGICAL INVESTIGATION OF THE ROOT EXTRACT OF TYPHONIUM TRILOBATUM

In the present study, the phytochemical screening, in vitro antioxidant activity, thrombolytic activity, membrane stabilizing activity, acute toxicity and anti-depressant activity were evaluated using Forced Swimming Test (FST) of the root extract of Typhonium trilobatum. Phytochemical evaluation was done by performing different chemical tests and the presence of flavonoid, carbohydrate and phenol...

F. Shafa, Md. Shahriar *, F. A. Dain Md. Opo , R. Akhter , M. Mahboob Hossain1 and N. Choudhury

Phytochemistry Research Laboratory, Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.7(4).1694-04

1694-04

2051

571

40.

ANTIOXIDANT ACTIVITY OF LEAF AND FRUIT EXTRACTS OF RAUWOLFIA TETRAPHYLLA LINN.

Four crude extracts viz, methanol extract of fruit and n-hexane, dichloromethane, methanol extracts of the leaf of R. tetraphylla were investigated for in vitro antioxidant activity at different concentrations (5, 50 and 100 μg). Antioxidant ability is expressed as equivalents of ascorbic acid and was calculated using standard graph. The results indicated that the leaf n-hexane and methanol extra...

K. N. Vinay , V. Venkata Lakshmi *, N. D. Satyanarayan and G. R. Anantacharya

Department of Chemistry , AMC Research Centre, Kalkere, Bangalore, Karnataka State, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1705-09

1705-09

2298

607

41.

CHEMICAL ANALYSIS OF THREE SAUDI MEDICINAL PLANTS AND THEIR ANTIBACTERIAL ACTIVITY AGAINST MULTI-DRUG RESISTANT BACTERIA

The present work aims to examine the antimicrobial activity of three medicinal plant extracts grown in Saudi Arabia namely Pulicaria crispa, Achillea fragrantissima and Cleome Africana against 10 clinical isolates of multi-drug resistant bacteria (MDR) that belong to four species, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumonia. The antibacterial pot...

Leena Zino , Abdulnaser Alsharaa *, Sahar Al-Dossary , Afnan Alwadey and Basheer Chanbasha

Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.7(4).1710-15

1710-15

2224

594

42.

EVALUATION OF THE ANTIMICROBIAL, ANALGESIC AND ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF THE LEAVES OF AVERRHOA CARAMBOLA

Aim: Evaluation of the antimicrobial, analgesic and antioxidant activity of ethanolic extract of the leaves of Averrhoa Carambola. Materials and methods: To test the antimicrobial activity the organisms used were S. aureus, Klebsiella sp, E. coli and P. aeruginosa, C. albicans. Zone of inhibitions produced by sensitive organisms were demarcated by a circular area of clearing around plant extract i...

Swopna Phukan and Atifa Ahmed

Department of Pharmacology, Gauhati Medical College and Hospital, Guwahati, Assam, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1716-23

1716-23

2924

796

43.

SIMULTANEOUS QUANTIFICATION OF TRAVOPROST AND TIMOLOL MALEATE IN PHARMACEUTICAL FORMULATION BY RP-HPLC

Travoprost and Timolol Maleate are used in treatment of glaucoma by decreasing intra ocular pressure. The present study was designed to develop and validate a simple, sensitive, precise, and specific reverse phase high-performance liquid chromatographic (HPLC) method for simultaneous determination of Travoprost and Timolol maleate in ophthalmic dosage form. Chromatographic separation of these two ...

Prasanthi Chengalva *, Angala Parameswari S and Jayachandra Reddy P

Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupathi, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1724-28

1724-28

3230

1038

44.

GC-MS ANALYSIS OF ETHYL ACETATE EXTRACT OF ELEUTHERINE BULBOSA (URBAN) MILLER (IRIDACEAE)

The present study was carried out to detect the phytoconstituents present in the bulbous part of Eleutherine bulbosa using Gas Chromatography-Mass Spectrometry (GC-MS) analysis.  The mass spectrum of the crude ethyl acetate extract was compared with the available library sources (NIST08LIB, WILEY 8 and FAME).  A total of 24 compounds were identified. Most of the major constituents were phenolic ...

V. S. Rani * and Bindu R. Nair

Department of Botany, University of Kerala, Kariyavattom, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1729-33

1729-33

2536

779

45.

FORMULATION, OPTIMIZATION & EVALUATION OF SOLID DISPERSION BASED GASTRORETENTIVE FLOATING TABLETS OF CEFPODOXIME PROXETIL

The objective of present study was to preclude of poor dissolution of relatively water insoluble and poorly permeable drug by formulating gastroretentive floating tablet using solid dispersion (SD) of the drug. It aimed to increase the drug solubility and gastric retention of the drug for better absorption profile. Cefpodoxime proxetil is an orally absorbed third generation cephalosporin antibioti...

Nidhi Saini*, Rakesh Kumar, Manju Yadav and Kamal Saroha

Institute of Pharmaceutical Sciencies, Kurukshetra University Kurukshetra, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1734-39

1734-39

2540

613

46.

ANTI-OXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF CUCUMIS SATIVAS (CUCUMBER) FLOWERS

Cucumis sativus (Cucumbers) have not received as much press as other vegetables in terms of health benefits, but this widely cultivated food provides us with a unique combination of nutrients. At the top of the phytonutrient list for cucumbers are its cucurbitacins, lignans, and flavonoids. These three types of phytonutrients found in cucumbers provide us with valuable antioxidant, anti-inflammato...

N. Muruganantham *, S. Solomon and M.M. Senthamilselvi

Department of Chemistry, Roever Engineering College, Perambalur, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1740-45

1740-45

3820

824

47.

EFFECTIVENESS OF ANTI-INFLAMMATORY PLASTER FROM KENCUR (KAEMPFERIA GALANGA L.) RHIZOME ETHANOL EXTRACT

Kencur (Kaempferia galanga L.) is a plant of Zingiberaceae family. Some studies have shown that kencur can reduce inflammation because flavonoid kaempferol which is contained in kencur has anti-inflammatory activity. Optimized the use of the rhizome kencur, research was conducted on anti-inflammatory plaster containing kencur rhizome extract and its effectiveness for treating inflammation. The stu...

Hesti Riasari, Revika Rachmaniar and Yessi Febriani

College of Pharmacy Indonesia Jl. Soekarno-Hatta No.354 (Parakan Resik), Bandung, Indonesia

DOI: 10.13040/IJPSR.0975-8232.7(4).1746-49

1746-49

2963

1043

48.

CYTOGENETIC STUDY OF CHROMOSOMAL ABERRATIONS ASSOCIATED WITH CHRONIC LEUKEMIA

The most common cause of death is bone marrow failure. Chromosomal analysis is essential for the diagnosis, response to treatment and prognosis of leukemia. The present study was done to know the chromosomal abbreviation in chronic leukemia of patients with in age group of 2 to 60 years. 32 male and 21 female patients have been analyzed for this study. The chosen leukemic patients were those who w...

D. N. Mishra , S. K. Panda , S. R. Das *, J. S. Prusti , S. Sahu , P. Panda and C. Mohapatra

Department of Anatomy , IMS and SUM Hospital, Siksha O Anusandha University, Bhubaneswar, Odisha, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1750-60

1750-60

2065

467

49.

PHYTO-CHEMICAL CONSTITUENTS FROM STEM OF TARAXACUM OFFICINALE WEBER

A new flavone glycoside 1 m. p. 223-225ºC, m. f. C34H42O20, [M+] 770 (FABMS) has been isolated from the stems of Taraxacum Officinal weber along with one known compound Taxifolin. A compound 1 was characterized as 6, 4′-dimethoxy-5, 7-dihydroxy-flavone- 7 - O - a - L-rhamnopyranosyl-(1®4) - O – β - D xylopyranosyl-(1®4)-O-β-D-glucopyranoside by various chemical degradations and spectral a...

Shirin Khan *, Kiran Duby , Rashmi Jain and Umesh Kumar Vishwakarma

Department of Chemistry, Govt K N. M. Mahavidyalaya, Damoh (M.P.), India

DOI: 10.13040/IJPSR.0975-8232.7(4).1761-64

1761-64

1812

561

50.

SYNTHESIS, EVALUATION AND QSAR STUDIES OF SOME SUBSTITUTED PYRAZOLE DERIVATIVES

In the present paper QSAR studies related to some novel substituted pyrazole derivatives are reported. All the compounds were evaluated for antmicrobial activity viz- antifungal activity against A. niger. Their reported antimicrobial activities were used for Quantitative Structure Activity Relationship (QSAR) studies to find correlation between different calculated molecular descriptor of the comp...

Kishor Arora* and Veena Nathani

Department of Chemistry, Goverment P.G. College (Auto.), Datia (M. P.) India

DOI: 10.13040/IJPSR.0975-8232.7(4).1765-72

1765-72

1902

522

51.

PROSPECTIVE OBSERVATIONAL STUDY ON PERI-OPERATIVE USAGE PATTERN OF ANALGESICS

The present work reports a prospective observational study to determine perioperative usage pattern of analgesics. Both general and regional anaesthesia and also different analgesics which is most effective to manage post operative pain were used. 120 patients were studied randomly as per criteria. Techniques of anaesthesia, pre, peri& post operative vitals and pain scores were noted in select...

S. Saha, S. Chakraborty, T. K. Chatterjee* A.K. Bandyopadhyayd, Sayantan Ray and J. Chakraborty

Department of Pharm. Tech., Jadavpur University, Kolkata, West Bangal, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1773-79

1773-79

1649

468

52.

EVALUATION OF NS1 ANTIGEN-CAPTURE ELISA AND IgM ANTIBODY CAPTURE ELISA IN ACUTE CASES OF DENGUE IN RURAL POPULATION IN A TERTIARY CARE TEACHING HOSPITAL IN WESTERN UTTAR PRADESH INDIA

Background: Dengue is a major public health problem in resource-limited countries like India. There has always been a quest for best serological test for prompt and accurate diagnosis and whether single test or a combination be used. Enzyme immunoassays based on the detection of dengue virus non-structural protein 1 (NS1), and IgM antibody capture are available with different sensitivities and spe...

Rajesh Kumar Verma*, Dharmendra Prasad Singh, Sunita Kumari and ME Siddique

Department of Microbiology, UPRIMS&R, Saifai, Etawah (UP), India.

DOI: 10.13040/IJPSR.0975-8232.7(4).1780-84

1780-84

2273

580

53.

STUDY OF THE EFFECT OF SODIUM VALPROATE ON ENHANCEMENT OF MONOAMINE MEDIATED BEHAVIOURAL RESPONSES AFTER ELECTROCONVULSIVE SHOCK (ECS) ADMINISTRATION IN RATS

Objectives: To obtain the data regarding the effects of sodium valproate on enhancement of monoamines mediated behavioural responses following administration of ECS for ten days to rats. Methods: Forty rats were selected for the study in which tonic-clonic seizures were developed fully after giving single maximal electroconvulsive shock (150V, 210mA). Four groups (n= ten in each) were received dif...

Jeetendra Singh, Tushar C. Baheti* and Mrunal S. Patil

Department of Pharmacology, Dr. Vasantrao Pawar Medical College, Hospital & Research Centre, Vasantdada nagar, Adgaon, Nashik, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1785-92

1785-92

1573

490

54.

COMPARATIVE IN-VITRO BIOLOGICAL STUDY OF AERIAL PARTS OF PLANT HAMELIA PATENS

Background: The plant Hamelia patens belong to a family Rubiaceae, which is rich in active phytochemicals like flavonoids and alkaloids. Although Plant has been traditionally used for the treatment of various ailments still no systematic pharmacognostical, phytochemical and pharmacological work has ever been carried out on this potential plant. Aim: The present study was carried out for the standa...

Shweta Singh* and Manju Vyas

Department of Herbal Drug Technology, DIPSAR (Delhi University), Pushp Vihar, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.7(4).1793-08

1793-08

2315

858