Volume 11 (2020) - Issue 1, January
Review Articles
EMERGING MECHANISMS AND POTENTIAL ANTIDEPRESSANT ACTION OF MEDICINAL PLANTS
Depression is a common heterogeneous, debilitating and life-threatening mood disorder affecting different segments of the community. Several chemical and synthetic medicines as standard are being employed to treat depression and may lead to complete recovery in only 50% of clinically depressed patients but causes many adverse effects. Thus, scientists are increasing their interest in research towa...
3073
2056
A REVIEW ON ANTI-BIOFILM INHIBITOR FROM PLANT ESSENTIAL OILS
Bacteria predominantly remain in a self-produced polymeric matrix, adherent to an inert or living surface. This microenvironment community of bacteria is known as biofilm. Commonly visualized as a slimy layer, a number of unique features distinguish biofilms from their planktonic counterparts. Formation of biofilms depends on the extracellular signals, mechanical, biochemical, environmental condit...
3420
1251
PURIFICATION STRATEGIES FOR MICROBIAL PHYTASE
Phytase catalyzes the formation and release of inorganic phosphate from phytic acid. A few monogastric animals that lack phytase is incapable of digesting phytate obtained from plants and gets excreted, which results in the accumulation of phosphorus in the form of phytate in the environment which has a detrimental effect. In order to combat this problem, researchers have focused on production and...
3044
1647
PTEN-A REVIEW
PTEN (phosphatase and tension homolog deleted on chromosome 10) is an important key factor in regulating intracellular for cell growth and proliferation by blocking the phosphatidylinositol -3kinase/ AKT protein kinase B (PI3K/Akt) pathway alteration in PTEN is concomitant with many diseases. PTEN is recurrently mutated in several pathological diseases which indicate its significance in general ph...
2845
891
CANDIDA, A HUMAN PATHOGEN AND MAJOR TYPES OF CANDIDIASIS
The fungus candida with over 355 species is an anamorphic yeast. It consists of over 20 human pathogenic species which are the cause of candidiasis. Candidiasis encompasses infections that range from superficial, such as oral thrush and vaginitis, to systematic and potentially life-threatening diseases. Candida species are opportunistic human pathogens which despite treatment with antifungal drugs...
5882
1581
Research Articles
PREPARATION AND CHARACTERIZATION OF ATENOLOL-β-CYCLODEXTRIN ORALLY DISINTEGRATING TABLETS
Atenolol is a hypertension drug that has a low solubility characteristic in water and gastric fluid. The rate of absorption of the drug with poor solubility characteristics is determined by the dissolution process. In this study, an attempt has been conducted to increase the dissolution of atenolol by increasing its solubility. The solubility of atenolol has been enhanced by the inclusion complex ...
6132
1548
A VALIDATED LC-MS/MS BIOANALYTICAL METHOD FOR THE SIMULTANEOUS DETERMINATION OF THREE ACE-INHIBITORS IN HUMAN PLASMA
A selective and rapid LC-MS/MS spectrophotometric method has been developed and validated for the simultaneous determination of three ACE-inhibitors used in anti-hypertensive therapy, namely enalapril maleate, perindopril, and ramipril in human plasma using high-performance liquid chromatography-tandem mass spectrophotometry (LC-MS/MS) with electrospray ionization (ESI). Separation of analytes and...
3332
1217
DEVELOPMENT AND CHARACTERIZATION OF ANTI-DANDRUFF NIOSOMAL HAIR GEL CONTAINING TEA TREE OIL
Dandruff is the excessive shedding of dead skin cells from the scalp, apparently caused by a fungus called Malassezia restricta and M. globosa. Malassezia formerly called Pityrosporum is a yeast causing infection of skin and scalp. Tea tree oil (TTO) is an essential oil that is obtained by steam distillation of the leaves and terminal branches of Melaleuca alternifolia (Myrtales: Myrtaceae). Tea t...
3949
1437
PHARMACOGNOSTICAL STANDARDIZATION OF PLANT CRYPTOLEPIS BUCHANANI ROEM. & SCHULT. AERIAL PART
Cryptolepis buchanani Roem. & Schult. (Family: Asclepiadaceae) commonly-known as Wax leaved climber, Kali Sariva in English and Sanskrit. It is broadly used in Ayurveda as a remedy of ailment. Though, its diverse medicinal aspects, no detail pharmacognostical study is available till date. The present study is to investigate the pharmacognostical characteristics of C. buchanani aerial part. The...
3292
1332
DEVELOPMENT OF OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM OF METFORMIN HYDROCHLORIDE
The aim of the present study was to formulate an osmotically controlled drug delivery system (O-CDDS) of Metformin hydrochloride to reduce the frequency of multiple dosing in non-insulin dependent diabetes mellitus-II which is a lifelong disease. Metformin hydrochloride a BCS Class-III drug having a poor biological half-life of 6 h. O-CDDS of Metformin hydrochloride is a recent approach for the ze...
2623
1092
STABILITY INDICATING ASSAY FOR DILTIAZEM AND ITS METABOLITES IN HUMAN PLASMA BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY FOR PHARMACOKINETIC APPLICATION
A simple and sensitive Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry method was developed to perform a stability study of diltiazem and its metabolites in human plasma using various buffer reagents at a different strength. The method was applied for the quantification of diltiazem and its two major metabolites N-desmethyl diltiazem and desacetyl diltiazem in human plasma. The an...
2282
1286
VALIDATED STABILITY INDICATING HPTLC METHOD FOR PROTOCATECHUIC ACID
Protocatechuic acid (PCA) is a type of widely distributed naturally occurring phenolic acid, commonly found in bran, grain, brown rice, fruits such as plums, gooseberries, grapes and also in onion peels. A new, simple, precise, accurate and sensitive stability-indicating HPTLC method for Protocatechuic acid was successfully developed. This method is based on HPTLC separation followed by UV detecti...
2090
862
DESIGN AND SYNTHESIS OF NOVEL HYDRAZONES OF ETHYL3-AMINO-4-HYDROXYBENZOATE AS PROMISING ANTICONVULSANT AGENTS
A series of hydrazide-hydrazones (3a-o) have been synthesized by the reaction of acid hydrazide (2) which is obtained from 4-carbomethoxy-2-aminophenol with aromatic acid through multi-steps. The bioactivities of the final compounds were tested with MES and scPTZ methods. The CNS toxicity was studied by the rotarod experiment. Based on the results, compounds 3d and 3o were found to be most active ...
2056
940
RUBBER SEED CLEANSING OIL FORMULATION AND ITS EFFICACY OF MAKEUP REMOVER
The objective of this study was to determine the safety of rubber seed oil in terms of toxicity, residual solvent and to develop rubber seed cleansing oil as a makeup remover. The cytotoxicity of rubber seed was determined on human fibroblast cell. It was not cytotoxic to human fibroblast cell at >1000 µg/ml. Rubber seed oil was further examined for the presence of linamarin toxin and determin...
3395
1511
PHYTOCHEMICAL SCREENING AND EVALUATION OF PHARMACOLOGICAL ACTIVITIES OF BUCHANANIA LANZAN SPRENG LEAVES
The aim of this research was to perform phytochemical screening and evaluation of the pharmacological activities of Buchanania lanzan Spreng. leaves. Preliminary phytochemical screening revealed the presence of phytoconstituents like steroids, tannins, saponins, carbohydrates, alkaloids, and flavonoids. Three leaf extracts were prepared by using solvents e.g. chloroform, ethyl acetate, and ethanol...
2314
1027
CYANOBACTERIA ASSISTED BIO-REDUCTION OF SILVER NANOPARTICLE CONJUGATES AND STUDY ON THEIR CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY AGAINST PATHOGENIC BACTERIA
Green nanotechnology has recently emerged as an area of research involving more eco-friendly and energy-efficient approaches for the synthesis of inorganic nanoparticles. The point of the present investigation is to evaluate the capacity of selected strains of freshwater Cyanobacteria (Microalgae) for their capability to biosynthesize silver nanoparticles by utilizing both live biomass of microalg...
2124
882
STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ERTUGLIFLOZIN AND METFORMIN IN BULK AND PHARMACEUTICAL DOSAGE FORM BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY
A simple, accurate, precise method was developed for the simultaneous estimation of the Ertugliflozin and Metformin in Tablet dosage form. For the method development, Chromatogram was run through HSS C18 (100 × 2.1 mm, 1.7µ) column at a flow rate of 0.3 ml/min. and buffer used in this method was Ortho Phosphoric Acid buffer. The temperature was maintained at 30 °C. The optimized wavelength sele...
2303
978
EFFECTIVENESS OF PROBIOTICS USE IN POULTRY FARMING
A bird is often subjected to dysbacteriosis with a low quality of feed. As a result, live weight gain and livability are reduced in broilers. This problem has become particularly acute now when most countries have abandoned the use of feed antibiotics. Significant assistance in this situation is provided by new regulators of intestinal biosynthesis - probiotics. In our research, we used biosporin ...
2126
819
STANDARDIZATION, FORMULATION DEVELOPMENT AND CHARACTERIZATION OF ANTIULCER DRUG: MUKTA BHASMA
Ayurveda is the holistic approach towards life, health, disease management through medicinal herbs minerals, diet and lifestyle leads to the great need for standardization of herbal medicine to maintain its safety and efficacy. Mukta bhasma is used in the treatment of bone metabolic disorders associated with calcium deficiency. It was prepared by Shodhana, Marana and Sharava samputa and the Standa...
2928
1287
DRUG DEVELOPMENT AND OPTIMIZATION FORMULA OF RANITDIN HCl GASTRORETENTIVE MUCCOADHESIVE FLOATING SYSTEM TABLET
Ranitidine hydrochloride (RHCl) is a histamine H2 receptor antagonist, it’s widely in active duodenum ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease, and erosive esophagitis. Ranitidine HCl has a short biological half-life of drug 2 - 3 h, has 50% absolute bioavailability, colonic metabolism of ranitidine HCl was partly responsible for the poor bioavailabilit...
2027
848
ANTIOXIDANT ACTIVITY OF A NEW FLAVONE GLYCOSIDE FROM THE STEMS OF GMELINA ARBOREA ROXB.
Gmelina arborea Roxb. belongs to the Verbenaceae family, commonly known as Gambhar. It is distributed throughout India, Ceylon, Malayan and Philippine Islands. Its roots have anthelmintic properties. Its flowers are useful in the treatment of leprosy and blood diseases. Its fruit has diuretic properties and aphrodisiac. It is also used in anemia leprosy and vaginal discharges. Leaves have shown an...
2115
828
STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF TWO SYNTHETIC ANTIBIOTICS, AMOXICILLIN AND ENROFLOXACIN, SIMULTANEOUSLY
This work proposes a precise, accurate, sensitive and selective stability indicating RP-HPLC method for the simultaneous quantification of amoxicillin and enrofloxacin in bulk powder and oral suspension formulations. Chromatographic separation was performed on the reverse phase C18 analytical column using 0.1M potassium dihydrogen orthophosphate–methanol (65:35, v/v) as mobile phase and with det...
2038
904
STRUCTURE ELUCIDATION AND THERAPEUTIC APPLICATIONS OF ENDOPHYTIC FUNGI DERIVED BIOACTIVE COMPOUNDS OBTAINED FROM XIMENIA AMERICANA WESTERN GHATS OF KARNATAKA INDIA
The objective of the present investigation was the bioprospection of pharmaceutically vital bioactive compounds from endophytic Thielaviopsis basicola with antagonistic and antioxidant activity isolated from Ximenia americana, Western Ghats of Karnataka, India. The fresh and healthy leaves and roots of Ximenia americana were collected from the forests of Western Ghats of Karnataka, India and subme...
2577
4067
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ERTUGLIFLOZIN AND METFORMIN HCl IN BULK AND PHARMACEUTICAL DOSAGE FORM BY HPLC
Analytical method for simultaneous estimation of Ertugliflozin (ERT) and Metformin hydrochloride (MET) was developed and validated by high-performance liquid chromatography (HPLC) as per ICH guidelines. The drugs were injected into the inertsil C18 (250 × 4.6 mm) maintained at room temp and wavelength 220 nm. The mobile phase consists of buffer (potassium dihydrogen pH 4.0) and methanol (65:35 v/...
3131
1152
PHYTOCHEMICAL STUDIES, FTIR AND GC-MS ANALYSIS OF HARDWICKIA BINATA ROXB. (FABACEAE / CAESALPINIACEAE)
Hardwickia binata belongs to family Fabaceae / Caesalpiniaceae and commonly known as ‘Anjan’. The present study includes phytochemical screening, FTIR and GC-MS analysis. Shade dried powdered leaves, seed and husk of H. binata extracted in petroleum ether, chloroform, ethyl acetate, acetone, methanol, ethanol, distilled water using Soxhlet apparatus and used for phytochemical analysis. Crude p...
2567
1114
EFFECT OF PLANT GROWTH REGULATORS ON SECONDARY METABOLITES ACCUMULATION AND ANTIOXIDANT ACTIVITY OF CATHARANTHUS ROSEUS L.
Secondary metabolites not only play a vital role in plant defense but also had shown various medicinal properties which provide a scientific base for using herbs and different plants as alternative medicines that were used by ancient communities. Many of the drugs today are simple synthetic modifications of the natural compounds. The developing commercial requirements of secondary metabolites in r...
2684
987
ANTIPLASMODIAL ACTIVITY OF AGANOSMA CYMOSA
Ethylacetate leaf extract of Aganosma cymosa was screened for antimalarial activities in-vivo in rats inoculated with red blood cells parasitized with Plasmodium falcipuram using 4-day Suppressive test and Rane’s test. The result of mean parasitemia by 4-day Suppressive test for the Group AC600, AC400 & AC200 was 4.62 ± 3.63, 13.34 ± 2.42, 19.29 ± 3.23 and percentage suppression were 80.1...
1588
864
CHEMOMETRIC APPROACH FOR RP-HPLC DETERMINATION OF DRONEDARONE USING RESPONSE SURFACE METHODOLOGY
The present study depicts the assessment of class III antiarrhythmic drug dronedarone in its drug substance and drug product. Response surface randomized central composite quadratic design has been employed for the optimization of method parameters using reverse-phase high-performance liquid chromatography (RP-HPLC) on Kromasil C18 250 × 4.6 mm, 5 µ with UV detection at 289 nm. The ranges of the...
1928
774
EFFECT OF POLYHERBAL COMBINATIONS AND ESSENTIAL OILS AGAINST BIOFILM OF STREPTOCOCCUS MUTANS
Background: Herbal extracts have been used in dental products for many years owing to their anti-adherence effect on Streptococcus mutans (S. mutans) in the biofilm formation. Dental caries are developed by the colonization of oral bacteria on the surface of teeth and adherence is the first step in the colonization process. Objective: The objective of the present study was to explore the anti-biof...
1920
788
ADSORPTION OF CIPROFLOXACIN FROM AQUEOUS SOLUTION ONTO FE3O4/GRAPHENE OXIDE NANOCOMPOSITE
In this research, ciprofloxacin adsorption (CIP) onto graphene oxide synthesized with Fe3O4 (Fe3O4-GO) was applied via various adsorbent dose, contact time, temperature and initial CIP concentration. The results showed that the percentage removal of CIP decreases from 98.1 to %77.4, as the CIP concentration increases from 25 to 200 mg/L. Also, the amount of CIP adsorbed per unit mass of adsorbent...
2303
892
HIGH-THROUGHPUT STRUCTURE BASED VIRTUAL SCREENING TARGETING CNS FOR INHIBITED ACETYLCHOLINESTERASE REACTIVATION
Organophosphorus (OP) nerve agents blocks acetylcholinesterase and do not allow the degradation of acetylcholine. Post-treatment of organophosphate poisoning involves the treatment with oxime reactivators as an antidote, which will dephosphorylate the phosphate bond between enzyme and nerve agent. Due to CNS permeability failure of these oximes, the introduction of low molecular non-oximes has bec...
1996
756
FORMULATION AND STABILITY EVALUATION OF CREAM CONTAINING CHROMOLAENA ODORATA AND CENTELLA ASIATICA LEAF EXTRACTS
Chromolaena odorata was extracted by ethanol/water. Centella asiatica was extracted by methanol. A cream containing C. odorata and C. asiatica extracts was formulated and evaluated for its physicochemical properties and stability. C. odorata and C. asiatica were extracted and their respective active compounds scutellarein tetramethyl ether and asiaticoside were determined as bioactive compounds us...
4090
2053
USE OF ELECTRON MICROSCOPY IN STUDY OF STEROIDOGENIC CELLS OF NORMAL, REGRESSING AND PREGNANT CAPRINE CORPORA LUTEA
Electron microscopic studies revealed variations in different cell organelles in steroidogenic cells of normal, regressing and pregnant caprine corpora lutea. Corpus luteum was comprised of two types of steroidogenic cells viz. small theca luteal cells and large granulosa luteal cells. In granulosa luteal cells, rough endoplasmic reticulum was most abundant in corpus luteum of pregnancy. The numbe...
1569
769
METHOD DEVELOPMENT FOR ESTIMATION OF DICLOFENAC SODIUM IN A CHOCOLATE DOSAGE FORM
A simple, rapid, precise, sensitive and reproducible Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) method has been developed for the quantitative analysis of Diclofenac sodium in the chocolate dosage form. Chromatographic separation of Diclofenac sodium was achieved on waters alliance-e2695, by using waters symmetry C18, 150 mm × 4.6 mm, 3.5 µm, column and the mobile phase conta...
3506
1354
HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF RIFABUTIN IN BULK AND CAPSULE DOSAGE FORM
A selective, accurate, HPLC method was developed by this study for the determination of rifabutin in bulk and capsule dosage form. This method was developed by SHIMADZU LC-2010 HT using C18 column in solvents methanol: acetonitrile: ammonium acetate buffer (50: 45: 05) as mobile phase. At 1.0 ml/min flow rate the mobile phase was pumped, and the sample was detected at 278 nm. For standard rifabuti...
2280
812
DESIGN, OPTIMIZATION AND EVALUATION OF BUCCAL DRUG DELIVERY SYSTEM OF PROPRANOLOL FOR HYPERTENSION TREATMENT
The main objectives of the present study were to design, optimization and evaluation of buccal drug delivery system of propranolol for hypertension treatment. Propranolol is non-selective β-adrenergic blockers. It shows first-pass metabolism so its bioavailability is decreased and its absolute bioavailability is only about 26%. The buccal tablets of propranolol formulated, by using different muco...
2021
812
STANDARDIZATION OF THE HYDRO-ALCOHOLIC EXTRACT OF AYURVEDIC VAGINAL FORMULATION (NA) BY USING CHROMATOGRAPHY (HPTLC, HPLC) AND SPECTROSCOPY (UV-VIS & FTIR & GC-MS) METHODS
The research herbal formulation prepared by mixing dried stem barks of Azadirachta indica A. Juss. and Saraca asoca Roxb. in equal amounts is standardized through pharmacognostic and phytochemical studies for assessing its efficacy in the treatment of leucorrhoea/vaginitis/ excessive white discharge. Pharmacognostical analysis revealed total ash value of 9.43% having 1.89% acid insoluble ash, 4.62...
1979
986
WOUND HEALING ACTIVITY OF METHANOLIC EXTRACT OF ARNEBIA BENTHAMII
Arnebia benthamii (synonym - Microtomia benthamii) commonly known as Ratanjot or Laljari found in western Himalayan region and used as wound healer roots by local vaids and tribes. The roots of Arnebia benthamii contain a red dye that is used in various health disorders like fungal infection, inflammation, fever and coloring/flavoring agent in Indian curries. To estimate wound healing potential of...
1887
1026
ESTIMATION OF WITHAFERIN – A FROM ASHWAGANDHADI LEHYA USING HPLC
Ashwagandhadi lehya is an Ayurveda formulation, official in Ayurvedic Formulary of India and used as aphrodisiac, tonic, rejuvenating agents etc. It is one of the major components of Ashwagandhadi lehya is Withania somnifera which contain Withaferin –A. The study was undertaken to develop an analytical method using HPLC to estimate Withaferin - A, being a marker from, methanolic extract of Ashwa...
2504
880
PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITY STUDIES OF LEAF OF BRASSICA JUNCEA VAR RUGOSA THROUGH SEQUENTIAL SOLVENT EXTRACTION
Objectives: To find out different qualitative and quantitative phytochemical properties, it’s in-vitro antioxidant properties and peroxidase activity of Brassica juncea var. Rugosa (record tro- 50197928) with fresh and sequential solvent extracts. Methods: The leaf sample of Brassica juncea var. rugosa was collected from Manipur and the sample was dried. The dried powder was extracted using Soxh...
2568
971
SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NOVEL BENZOTRIAZOLE DERIVATIVES
The vast investigations on the derivatives of 1, 2, 3-benzotriazole explore wide applicability for tagging and delivering a number of other heterocyclic nuclei with benzotriazole. In the present work, several derivatives of 1-(substituted)-5- [(N-benzotriazolo-methyl)-1, 3, 4-thiadiazolyl]- imidazole-2-thione have been synthesized and are evaluated for their anticonvulsant activity. The anticonvul...
1970
788
DESIGN AND CHARACTERIZATION OF CHRONOPHARMACEUTICAL DRUG DELIVERY OF PROPRANOLOL HYDROCHLORIDE
Objectives: In the present study, an effort was made to develop a novel pulsatile dosage form for the treatment of hypertension using Propranolol hydrochloride as a model drug. A time-delayed capsule was prepared by sealing the pellets inside the insoluble hard gelatin capsule body with an erodible hydrogel plug. Methods: The pellets were prepared by the Fluidized Bed Wurster (bottom spray) techni...
2030
979
SENSITIVE AND RAPID ESTIMATION OF SARECYCLINE, AN ANTIBIOTIC DRUG IN SPIKED HUMAN PLASMA BY LC-MS/MS
Sarecycline, a narrow spectrum tetracycline-derived antibiotic, is used to treat moderate to severe Acne vulgaris. The current study is aimed at developing a simple, sensitive and accurate liquid chromatography-tandem mass spectrometric (LC/MS/MS) method and validating the same for determination of sarecycline in human plasma. Zorbax, SB C18, 4.6 mm × 75 mm, 3.5 μm, 80 Å column, 10 mM ammonium ...
1948
1047
FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES LOADED WITH BACOSIDE RICH EXTRACT
The treatment of neurodegenerative disorders such as Alzheimer's disease (AD) becomes much more difficult due to the presence of the blood-brain barrier (BBB). Various synthetic drugs are used for the treatment of Alzheimer’s disease, but the use of herbal products has increased tremendously nowadays. An important medicinal plant widely used therapeutically is Bacopa monnieri (Brahmi), a well-kn...
2860
2091
ANTIOXIDATIVE AND HYPOLIPIDEMIC EFFECT OF PUERARIA TUBEROSA WATER EXTRACT (PTWE) IN RATS WITH HIGH FAT DIET INDUCED NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) is chronic liver diseases ensuing from excessive fat accumulation in liver attributed to high dietary fat and carbohydrate and lower hepatic activity. It is associated with obesity and high BMI (body mass index). The excess carbohydrate-rich diet activates its conversion to TG (triglycerides), which gets accumulated in adipose and non-adipose tissues in th...
1888
809
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ERLOTINIB HYDROCHLORIDE BY SOLID DISPERSION TECHNIQUE WITH POLOXAMER 188: PREPARATION AND IN-VITRO EVALUATION
Solid dispersions (SDs) of Erlotinib hydrochloride (ETN) were prepared to enhance the solubility by solvent evaporation (SE) and Melting (MM) method using poloxamer 188 (PL 188) in the ratio of 1:1, 1:3 and 1:5 (w:w). The solubility of the drug was increased in a concentration-dependent manner of polymer and follow linearity order. The solid dispersion was characterized by Fourier transform infrar...
2329
869
THE EVALUATION OF VITAMIN C SUPPLEMENTATION ON NUTRITIONAL STATUS OF PATIENTS WITH ACUTE MYELOID LEUKEMIA UNDERGOING CHEMOTHERAPY
Background: Leukemia is the seventh common cancer in Iran, and AML is considered as the most common type. Malnutrition is common among patients with cancer. Vitamin C deficiency has a high prevalence among patients with cancer, which may influence a patient's survival chance. This study was aimed to evaluate the effect of vitamin C supplementation on nutritional status and serum albumin in patient...
2004
794
PHARMACOLOGICAL EVALUATION OF THE IN-VIVO ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE ESSENTIAL OIL FROM CYMBOPOGON OLIVIERI (BOISS.) BOR.
Cymbopogon olivieri (Poaceae) is a native plant to the south of Iran and is used for the treatment of some inflammative based disorders and as a pain killer. Regarding the presence of volatile terpenoids in the aerial parts, we were prompted to investigate the analgesic and anti-inflammatory activities of the essential oil from C. olivieri in animal models. The oil was also analyzed by GC and GC...
1708
809
DESIGN AND CHARACTERIZATION OF SOME NEW NON-SYMMETRIC SUBSTITUTED TRIAZINES AND TRIAZINE DERIVATIVES
Attempts were made to carry out the laboratory synthesis of non-symmetric mono-, di- and tri- substituted 1, 3, 5-triazines by the action of the electron-donating substituent on 2, 4, 6-trichloro-1, 3, 5-triazines by aromatic nucleophilic substitution reaction mechanism (SNAr reaction) by temperature controlled. The introduction of the amino group (-NH-), ether (-O-) and thiol (-S-) Linker Bridge ...
1699
1368
ANTIFUNGAL ACTIVITY OF AMPHOTERICIN-B ETHOSOMAL GEL AGAINST CANDIDA ALBICANS: A COMPARATIVE STUDY
Amphotericin B is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. Work aimed to formulate the amphotericin B (AmB) ethosomal gel (EF), evaluate its antifungal activity against fungal isolates of human origin and compare its antifungal activity with marketed liposomal gel (MLG). AmB ethosomal gel (EF) was formulated and characterized for thei...
2365
930
THE PROTECTIVE ROLE OF RAPHANUS SATIVUS ROOTS IN REVERSING THE RENAL ALTERATIONS AND OXIDATIVE DAMAGE AGAINST STREPTOZOTOCIN INDUCED DIABETES IN RATS
Oxidative stress and hyperglycemia are two major factors implicated in the development of renal damage. Roots of Raphanus sativus have been reported to possess both ant diabetic and antioxidant activities. So, the present study was aimed to investigate whether aqueous root extract of Raphanus sativus (ARRS) is effective in reversing the renal alterations and oxidative damage against streptozotocin...
2408
908
A STUDY ON PARAMOUNTCY OF COGNITIVE PHARMACEUTICAL CARE IN DRUG-DRUG INTERACTION AMONG IN PATIENTS
Drug-drug interactions (DDIs) are known for their potential to cause adverse clinical outcomes, rate of morbidity and mortality. An integrated approach to cognitive pharmaceutical care (CPS) would decrease the incidence of DDIs in hospitalized patients. This prospective interventional study was carried out among the inpatients admitted to a tertiary care multispecialty hospital in Chennai. A total...
1754
856
ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF HYPTIS SUAVEOLENS
Plants have served as a source of new pharmaceutical products and inexpensive starting materials for the synthesis of some known drugs. Components with medicinal properties from plants play an important role in conventional Western medicine. In the ethnopharmacological approach, local knowledge about the potential uses of the plants is very useful as compared to the random approach where indigenou...
2145
912
SYNTHESIS AND MOLECULAR DOCKING STUDY OF BIOACTIVE QUINOLINO- BENZIMIDAZOLE DERIVATIVES
A series of some quinolino-benzimidazole/thiazole derivatives (3a-3h) have been synthesized from2-hydroxyquinoline-3-formaldehyde derivatives (1a-1d) and 1, 2-phenylenediamines/2-aminothiophenols (2a-2c). The synthesized compounds were characterized by FTIR, 1H-NMR and Mass Spectrometry. All the compounds were screened in-vitro for their antibacterial activity against Mycobacterium tuberculosis (H...
1610
775
PHYTOCHEMICAL SCREENING, SILVER NANOPARTICLE SYNTHESIS AND ANTIBACTERIAL STUDIES ON THE LEAVES OF AESCHYNOMENE ASPERA L.
Green synthesis is one of the best routes for the silver nanoparticles (AgNPs). The present study revealed that the aqueous leaf extracts of Aeschynomene aspera, which contains alkaloids, flavonoids, phenols, terpenoids, anthocyanidins, indoles, glycosides, saponins and tannins, is found to be responsible for bioreduction during the synthesis of silver nanoparticles (SNPs). The colour change from ...
1720
982
ISOTRETINOIN ANTI-ACNE GEL FOR THE MANAGEMENT OF P. ACNE INFECTION
The object of the paper is the development of anti-acne gel of isotretinoin and evaluated for as potential formulation to treat Acne vulgaris. The isotretinoin based anti-acne gel was prepared by using carbopol 940 polymers and evaluated for solubility, drug interaction, drug release, pH, viscosity and spreadability. In-vitro drug release through Franz diffusion cells, acute skin irritation test a...
2651
744
STUDY OF THERAPEUTIC OUTCOME AND MONITORING OF ADVERSE DRUG REACTIONS (ADRS) IN PATIENTS COMING TO OUTDOOR PATIENT DEPARTMENT (OPD) OF DERMATOLOGY, VENEREOLOGY AND LEPROSY IN TERTIARY CARE HOSPITAL OF NORTHERN INDIA
Introduction: Cutaneous adverse drug reactions (CADRs) associated with significant morbidity and mortality are probably the most frequent of all manifestations of drug sensitivity. Material and Methods: It was a prospective observational study where newly diagnosed patients with ADRs reporting to OPD of Dermatology, K.G.M.U, Lucknow and satisfying inclusion criteria were enrolled. The various stud...
2275
995
THE EVALUATION OF VITAMIN C SUPPLEMENTATION ON NUTRITIONAL STATUS OF PATIENTS WITH ACUTE MYELOID LEUKEMIA UNDERGOING CHEMOTHERAPY
Background: Leukemia is the seventh common cancer in Iran, and AML is considered as the most common type. Malnutrition is common among patients with cancer. Vitamin C deficiency has a high prevalence among patients with cancer, which may influence a patient's survival chance. This study was aimed to evaluate the effect of vitamin C supplementation on nutritional status and serum albumin in patient...
1526
849