Volume 6 (2015) - Issue 1, January
Review Articles
SOME DRUGS IN ACTION: METAL IONS DO INFLUENCE THE ACTIVITY!
A large no of synthetic and natural compounds behave as very effective drugs. All these compounds have a wide range of biological activities like anti-bacterial, anti-fungal, anti-cancer, anti-viral, anti-inflammatory, anti-neoplastic, anti-tumorigenic, anti-HIV and so on. On the other hand, metals have played an important role in medicine for years. Many are essential in our diets in varying quan...
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CHITOSAN & ITS DERIVATIVES: A REVIEW IN RECENT INNOVATIONS
Chitosan a natural polymer available and easy to produce in countless parts of the world; is a material that can significantly improve the standard of living in developing countries where the industry is often surpassing the need to protect the environment and/or where the environment protection is strongly dependent on limited financial resources available to those in charge of environmental prot...
14786
3851
INTRINSIC MITOCHONDRIAL APOPTOTIC PATHWAYS; AN IMPERATIVE FEATURE OF CISPLATIN CYTOTOXICTY
Up till now, the most thriving and extensively used antineoplastic agent with well-established effectiveness is cisplatin. Being a non-specific drug, it reacts not only with genomic DNA but also binds and damages the plasma protein and cytoplasmic protein that confers to cisplatin resistance and severs side effects. DNA damage prompted by cisplatin leads to the activation of many signaling cascade...
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1129
RECENT INNOVATIVE APPROACHES TO ENHANCE THE EFFICACY AND SAFETY OF ANTICANCER DRUGS: A COMPREHENSIVE REVIEW
Developing innovative delivery strategies remains an ongoing task to improve bothefficacy and safety of drug-based therapy. Anti-cancer drug treatment is seriously affected by various undesirable properties such as poor solubility, narrow therapeutic index and efflux transporter specificity. One of the primary aspects of a successful cancer treatment regimen is to deliver sufficient amounts of dru...
3812
1314
A REVIEW ON ENDEMIC INDIAN RESURRECTING HERB SELAGINELLA BRYOPTERIS (L.) BAK. ‘SANJEEVANI’
Selaginella bryopteris (L.) Bak. usually known as “Sanjeevani’, is a lithophyte with remarkable resurrection capabilities and medicinal properties. It is traditionally used for curing wounds and irregular menstruation, uterine disorders and other internal injuries. It contains a variety of secondary metabolites such as alkaloids, phenol and terpenoids etc due to which it can act as antioxidant...
13481
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NANOPARTICLE TECHNOLOGY: FORMULATING POORLY WATER-SOLUBLE COMPOUNDS: A REVIEW
One of the biggest challenges faced by pharmaceutical scientists is poor solubility and bioavailability of new chemical entities (NCEs). According to BCS classification; approximately 25% of all compounds are classified as highly soluble and permeable. Nearly 40% of the new chemical entities currently being discovered are lipophilic so poorly water soluble drugs. BCS Class II and Class IV have low...
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A REVIEW ON MEDICINAL IMPORTANCE OF EMBLICA OFFICINALIS
Research in medicinal plants has gained a renewed focus recently. The prime reason is that other system of medicine although effective come with a number of side effects that often lead to serious complications. Plant based system of medicine being natural does not pose any serious problems. Although Emblica officinalis has a range of medicinal applications, but it is the need much period of time ...
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REGULATION OF NON-CANONICAL WNT SIGNALING PATHWAY IN STEM CELLS DEVELOPMENT AND CARCINOGENESIS
Since 1982, Wnt1 (Wingless int-1) was first identified in mammary carcinoma. Further, Wnt signaling pathway was discovered. Wnt signals were involved in stem cells development, regeneration, cell cycle and repair mechanism. Finally abnormality Wnt signals were stimulated variety of cancers. Especially, non-canonical signaling pathways such as Wnt/PCP and Wnt/Ca2+ pathway were involved in developme...
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1271
NEUTRACEUTICALS AS ADJUNCT TREATMENT DURING CHEMO- OR RADIO-THERAPY FOR CANCER: A REVIEW
Today, Proliferation is being observed in neutraceutical industry due to health seeking consumer trend.Neutraceutical has evolved from health promoting to disease preventing supplements. Various herbs and their phytochemicals discussed in the present review can prove potent neutraceuticals as they are pharmacologically safe and provide advantages in terms of suppressing tumor progression, increasi...
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Research Articles
DETERMINATION OF A POORLY SOLUBLE DRUG, IBUPROFEN IN RAT PLASMA BY A SIMPLE HPLC ANALYSIS AND ITS APPLICATION IN PHARMACOKINETIC STUDY
In this study, a reversed-phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantification of ibuprofen in rat plasma. The mobile phase consisted of a mixture of acetonitrile and water that was adjusted to pH 2.5 using orthophosphoric acid (70:30). The flow rate was set at 0.5 ml/min and effluent was monitored by using UV detector at a wavelength of 223 nm wi...
4605
1798
FACILE SPECTROPHOTOMETRIC DETERMINATION OF METRONIDAZOLE AND SECNIDAZOLE IN PHARMACEUTICAL PREPARATIONS BASED ON THE FORMATION OF DYES
A rapid and sensitive spectrophotometric method is proposed for the determination of Metronidazole and Secnidazole drugs. The method depends on the reduction of Metronidazole and Secnidazole molecules with zinc dust and hydrochloric acid followed by diazotization and coupling with α-naphthylamine to give red colored chromogens easily measured spectrophotometrically at λmax = 510 nm or coupling w...
3918
1576
MORPHO-ANATOMIC INVESTIGATION OF VEGETATIVE ORGANS OF WATER AVENS (GEUM RIVALE L.)
Species of Geum L. genus (avens) of Rosaсeae L. family belong to perspective sources of medicinal plant raw material for obtaining medicines with the anti-microbic and anti-inflammatory action. They are characterized by such an important feature as the presence of biologically active substances, particularly the polyphenol compounds. According to the aim of present work, morphologic and anatomic...
3090
1179
ANTIMICROBIAL, CYTOTOXICITY, FREE RADICAL SCAVENGING ACTIVITIES AND COMPOUNDS ISOLATED FROM THE ROOTS OF HEMIDESMUS INDICUS (LINN.) R. BR.
Hemidesmus indicus Linn. R. Br. is a twining shrub traditionally used for the treatment of various diseases and ailments in the rural area of Bangladesh. Different extracts (methanol, hexane, ethyl acetate, n-butanol and water) from the roots of this shrub tested for their antimicrobial, cytotoxicity and free radical scavenging activities. All extracts showed moderate free radical scavenging act...
3432
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NEUROPROTECTIVE EFFECT OF EXTRACT OF ANACARDIUM OCCIDENTALE LINN ON A ROTENONE MODEL OF PARKINSON´S DISEASE
In this study the neuroprotective activity extract hydroalcoholic of AO against behavioral and biochemical parameters induced by subcutaneous injection of rotenone was evaluated, important for the understanding of Parkinson´s disease, which is the most common neurodegenerative disorder affecting movement. Rotenone is a potent hydrophobic pesticide and a highly selective inhibitor of complex I in ...
4198
1312
PREVALENCE AND FACTORS ASSOCIATED WITH HIV AND HEPATITIS B VIRUS INFECTIONS AMONG FEMALE COMMERCIAL SEX WORKERS IN MEKELLE, ETHIOPIA: CROSS SECTIONAL STUDY
Background: Sexually Transmitted Infections remain major public health problems among the most at risk population groups such as female commercial sex workers. Objective: To assess the magnitude of Hepatitis B Virus and HIV/AIDS and identify the associated factors among female commercial sex workers. Methodology: A Community Based Cross Sectional Study was conducted in Mekelle city. A total of 319...
3417
1407
ANTI NOCICEPTIVE ACTIVITY OF ARGENTUM NITRICUM, STAPHYSAGRIA, IGNATIA AMARA IN MICE IN COMPARISON WITH ACETYL SALICYLIC ACID (ASPIRIN)
Pain is a condition that is experienced by everybody in its life irrespective of humans or animals, reason could be due to any intense stimuli. It is a common phenomenon in vertebral animals similar to that felt by humans. This study was designed to determine theanalgesic activity of Argentum Nitricum, Staphysagria and Ignatia Amara in comparison with Acetyl salicylic acid. For this purpose the me...
5958
1321
MANAGEMENT OF ANTIMALARIAL DRUGS IN THE URBAN PUBLIC HEALTH FACILITIES IN TANZANIA
Frequent drug shortage, poor storage conditions and inadequate knowledge of health care workers for inventory management are among the factors affecting the supply chain of antimalarial drugs in Tanzania. These factors largely contribute to poor quality, shortage and irrational use of antimalarial drugs in the public health facilities. The aim of this study was to assess the management of ant...
3794
1343
MOLECULAR DOCKING SIMULATION STUDY OF PHYTOESTROGENS FROM ASPARAGUS RACEMOSUS IN BREAST CANCER PROGRESSION
Phytoestrogens are the xenoestrogens which are derived from the plant. This is the first report providing the deeper inside into the mechanism involved in restricting breast cancer progression with the help of docking simulation by phytoestrogen. Docking experiment bring to light that phytoestrogens prevents the binding of oestradiol with its receptor, thereby down regulating the signalling pathwa...
4524
1529
EXPERIMENTAL DESIGN APPROACH TO OPTIMIZATION OF THE NEW COMMERCIAL RP-HPLC DISCRIMINATION CONDITIONS FOR THE ESTIMATION OF PARACETAMOL AND ZALTAPROFEN IN PHARMACEUTICAL FORMULATION
A simple, rapid, RP-HPLC method developed for the simultaneous estimation of paracetamol and zaltaprofen in commercial pharmaceutical formulation by applying Derringer’s desirability function. The dependent variables such as Capacity factor of first peak, α value and retention time of tR3 as the responses with three important independent factors of organic phase composition, pH of mobile phase ...
3068
1136
CARDIOPROTECTIVE ROLE OF AMLODIPINE UNDER ACUTE HYPOBARIC HYPOXIA: ROLE OF AKT-1 IN REDOX BALANCE
Hypobaric hypoxia induced systolic heart dysfunction and arrhythmia is prevalent in ascendants. L-type calcium channel blocker amlodipine plays important role in modulating cardiac function. We tested if amlodipine could impart cardio protection and restore oxidative balance under hypobaric hypoxia, by modulating HIF-1α activity and calcium accumulation, thus, protects from cardio-toxicity. Exper...
1229
342
OCTENYL SUCCINATE CASSAVA STARCH AS AN EXCIPIENT FOR CONTROLLED RELEASE OF THEOPHYLLINE: MICROWAVE-ASSISTED SYNTHESIS, CHARACTERIZATION AND IN-VITRO DRUG RELEASE STUDIES
Octenyl succinate derivatives (OSA) of cassava starch having different degree of substitution (DS) were synthesized by microwave irradiation in solid state using a monomode reactor and the drug, theophylline (Thp) was successfully incorporated in the modified starches for getting controlled release properties. The reaction conditions were optimized for maximizing the DS by response surface methodo...
3449
1681
NOVEL 2 – AMINO – N’ – (2-OXOINDOLIN – 3 – YLIDENE) BENZO [d] OXAZOL – 5 -CARBOHYDRAZIDES AS ANTI-INFLAMMATORY AGENTS
In the present work , novel 2-Amino-N'-(2-oxoindolin-3-ylidene) benzo[d]oxazole-5-carbohydrazides were synthesized and evaluated for In-vivo anti-inflammatory activity by carragenan induced rat paw edema method and were known to exhibit promising anti-inflammatory activity at a dose of 30mg/kg bw. Compounds D2, D3, D5 and D8 were found to be comparatively potent with the standard Indomethacin....
3045
1696
DEVELOPMENT AND VALIDATION OF BIO-ANALYTICAL RP-ULTRA FAST LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF CLOPIDOGREL AND ROSUVASTATIN IN HUMAN PLASMA
ABSTRACT: This manuscript describes a simple, sensitive, rapid and precise Ultra fast liquid chromatographic (UFLC) method was developed and validated for the simultaneous determination Clopidogrel and Rosuvastatin in human plasma according to USFDA draft guidelines. In the current study, the analysis was performed on phenomenex C8 (250 × 4.6mm, 5μm) column using phosphate buffer (pH-2.5) and ac...
3383
1140
ASSESSMENT OF MEDICATION ERRORS IN PSYCHIATRY PRACTICE IN A TERTIARY CARE HOSPITAL
Objectives: To determine the incidence, causes, patterns, outcomes and predictors of medication errors (ME) in psychiatric practice. Methodology: A prospective observational study was conducted in the psychiatry department of a tertiary care hospital over a period of 6 months. Patients of either sex and aged ≥ 18 years receiving at least one psychotropic agent were included in the study and anal...
4860
1328
EVALUATION OF BIOACTIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF SOME WILD FRUITS BY IN-VITRO ASSAYS
The present study aimed to evaluate bioactive compounds and total antioxidant activity of differentfruits viz Phyllanthus emblica, Limonia acidissima, Syzygium cumini, Artocarpus hirsutus, Carissa congesta, Anacardium occidentale. Phytochemical study confirms the presence of carbohydrates, proteins, amino acids, cardiac glycosides, steroids, terpenoids and flavonoids in all the fruit extract. Asco...
3097
1406
SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND EVALUATION OF ANTI-TUMOR PROPERTIES OF NOVEL FATTYACID CONJUGATES OF 2, 4 AND 2, 6-DIISOPROPYLPHENOL
The present study enumerates the synthesis, spectroscopic characterization, and evaluation of antitumor properties of esters of two fatty acids viz., 5-hexenoic acid and iso- ricinoleic acid with 2, 4- or 2, 6-diisopropylphenol (Propofol). Propofol is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit...
3274
1192
ISRADIPINE ENHANCES THE ANTICONVULSANT ACTIVITY OF CARBAMAZEPINE AGAINST MES AND PTZ INDUCED CONVULSIONS IN RATS
The aim of this study was to investigate the possible anticonvulsant effect of a Dihydropyridine calcium antagonist, Isradipine, which easily crosses the blood–brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures and PTZ induced seizures. The seizures were induced in rats by maximum electroshock method and...
3183
1118
STRUCTURE ELUCIDATION AND ANTIHEPATOTOXIC ACTIVITY OF CIS AND TRANS ISOMERS OF PIPERINE ISOLATED FROM DRIED FRUITS OF PIPER LONGUM
The two pure phytochemicals characterized as cis-piperine and trans-piperine isolated from the dried fruits of Piper longum were tested for antihepatotoxic activity at the dose of 50 mg/kg orally respectively, against silymarin as a standard reference. The toxicity was induced by CCl4, and then various biological parameters such as AST, ALT, ALP, SOD, GPx, GSH, total protein, total albumin and tot...
4068
1306
THE ANTIANGIOGENIC, ANTIOXIDANT AND PROAPOPTOTIC CHEMOPREVENTIVE PROPERTIES OF TANNINS FROM MEMECYLON MALABARICUM (Cl.)
Tannins, the non-nutritive substances from plant sources exhibit potent biological activities that lower the risk of chronic diseases without any side effects. Tannins are most abundant and multipotent molecules exhibiting antioxidant, proapoptotic and antiangiogenic activity and thus being effective in the treatment of degenerative diseases including initiation and progression of tumors. The ...
3875
1556
ISOLATION OF COUMARIN COMPOUND FROM THE BARK OF BAUHINIA PURPUREA
Objectives: The study aimed to isolate coumarin compound from Bauhinia purpurea bark. Method: The bark was extracted successively with methanol in a soxhlet apparatus. The crude mass was subjected to HPLC, as well as column chromatography and eluted with methylene dichloride – methanol system with increasing methanol ratio to isolate compound BP. The structure of compound BP was identified by va...
4484
1749
SCREENING OF AN INDIGENOUS MEDICINAL PLANT – MADHUCA LONGIFOLIA FOR ITS ANTIOXIDANT AND ANTIMICROBIAL PROPERTIES
Madhucalongifolia is an economically important medicinal tree growing throughout the subtropical region. This research article deals with the antioxidant and antimicrobial properties of M. longifolia. The antioxidant properties of the seed were determined by hydrogen peroxide scavenging activity and reducing power assay. The methanol extract exhibited more antioxidant activity than water extract...
3116
1137
A KINETIC AND MECHANISTIC APPROACH TO PROTECTION AND REPAIR OF TERT-BUTOXYL RADICALS INDUCED URACIL RADICALS BY CHLOROGENIC ACID
The rates of oxidation of uracil and chlorogenic acid (CGA) by tert-butoxyl radicals have been studied by measuring the absorbance of uracil at 258 nm and CGA at 328 nm spectrophotometrically. tert-butoxyl radicals are generated by the photolysis of tert-butyl hydroperoxide in presence of tert-butyl alcohol to scavenge ·OH radicals. The rates and the quantum yields (f) of oxidation of CGA by t-Bu...
2881
1027
EVALUATION OF ANTI-MICROBIAL ACTIVITY AND WOUND HEALING OF KEFIR
Objective: Pseudomonas aeruginosa has emerged as an important cause of serious wound infection and death in burn patients. There are a limited numbers of antimicrobial agents affecting the bacterium due to its inherent resistance. Kefir is a natural probiotic which contains diverse spectrum of bacteria, yeasts and their metabolites with potential antimicrobial activity. Current study was designed ...
5038
1465
IN-VITRO CYTOTOXIC ACTIVITY OF LEAF EXTRACTS OF IPOMOEA JACQ. SPECIES AGAINST A 549AND HEP-G2CELL LINES
Members of the genus Ipomoea of family Convolvulaceae besides being some of the most beautiful ornamental plants cultivated for their bell shaped flowers, are also of medicinal value, with some of them reported as cytotoxic agents against some cancer cell lines. The present study evaluates the anticancer activity of the leaf extracts of ten Ipomoea Jacq. Species growing in and around Mumbai,...
5388
1737
AMNESIC POTENTIALITY OF DIAZEPAM AT LOW DOSE ON ADMINISTRATION VIA TRANSCRANIAL ROUTE IN RODENTS
The objective of study to evaluate a drug Diazepam applied transcranially to brain targeted drug delivery to screening for its amnesic effects, in different learning and memory paradigms viz., rod walking test, locomotor activity test, elevated plus maze test, water maze test, pole climbing test and pole climbing test on trained animal. Diazepam 4mg/ kg intraperitoneal used as a standard for com...
3322
7789
ANTI-DIABETIC EFFECTS OF ECLIPTA ALBA ON ALLOXAN-INDUCED DIABETIC MICE
The aim of the present study was to investigate the effects of Eclipta alba leaves extract on the biochemical parameters in alloxan induced diabetic Swiss albino mice. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 135 mg/kg body weight. Ethanolic extracts of E. alba leaves at dose of 200 mg/kg body weight were given orally in diabetic mice daily for fou...
3345
1193
ETHNOPHARMACOBOTANICAL INFORMATIONS OF SOME HERBACEOUS MEDICINAL PLANTS USED BY TODA TRIBES OF THIASHOLA, MANJOOR, NILGIRIS, WESTERN GHATS, TAMILNADU, INDIA
The present paper highlights the therapeutic uses of herbaceous medicinal plants used for various ailments by Toda tribe living in the pockets of Western Ghats of Tamil Nadu are inhabitants of Thiashola, Manjoor, Nilgiri District. A total of 32 plant species belonging to 18 families used by them as herbal medicines to treat several common diseases such as Asthma, antidote, contraceptive and ni...
4668
1912
Cu (II) METAL COMPLEXES OF SCHIFF BASES, PREPARATION, CHARACTERISATION AND BIOLOGICAL ACTIVITY
Heterocyclic schiff bases of 2-amino-4, 6-dimethyl benzothiazole with selected heterocyclic α- hydroxy aldehyde and α-hydroxy ketones and their Cu (II) metal complexes have been synthesised. The Cu (II) metal complexes of schiff bases are reported and characterised based on elemental analysis, IR, 1H NMR, ESR, XRD, Thermal analysis, magnetic moment, and molar conductance. The molar conductance d...
3283
1360
ECO-FRIENDLY AND COST-EFFECTIVE UV SPECTROSCOPY METHOD FOR THE ESTIMATION OF PREDNISOLONE SODIUM PHOSPHATE IN BULK AND PHARMACEUTICAL DOSAGE FORM
Prednisolone Sodium Phosphate (PSP) is a steroidal anti-inflammatory or immune suppressive agent. It is a sodium salt of the phosphoester of the glucocorticoid prednisolone. It is freely soluble in water; soluble in methanol; slightly soluble in alcohol and in chloroform; and very slightly soluble in acetone and in dioxane.A simple spectrophotometric method was developed for the determination of ...
3299
2092
A NOVEL SUSTAINED RELEASE ROBUST MATRIX PELLETS OF GLIPIZIDE
Multiparticulate drug delivery system are mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some amount desired characteristics such as pellets.The purpose of present study was to prepare sustained release robust matrix pellets of Glipizide. The study revealed successful application of factorial design, optimization of extrusion spheronization process, ...
3020
1583
MORINDA PUBESCENS BARK EXTRACTS SHOWS ANTIMICROBIAL ACTIVITY
Morinda Pubescens belonging to the family rubiaceae has been reported to posses many medicinal properties according to indigenous system of medicine. The search for biologically active compounds from natural sources has always been of great interest to researchers looking for new drugs useful in infectious disease. In the present study, the various extracts of Morinda Pubescens bark was tested for...
4827
1249
NEW MICROBIAL SOURCES OF PUFA FROM THE ARABIAN SEA AND FRESH WATER HABITATS OF INDIAN TERRITORY
Polyunsaturated Fatty Acids (PUFA) have been shown to be of major importance in the prevention and treatment of a range of human diseases and disorders. A number of microorganisms have been shown to produce and accumulate PUFA. In the current study we have isolated 86 lipid producing microbes from various sources like a river from northern India, lakes from southern India and marine environments o...
3402
1507
ACUTE TOXICITY STUDY OF ETHANOLIC EXTRACT OF SOLANUM LYCOPERSICUM (LEAF) IN SWISS ALBINO MICE
The Present Study was planned to assess the acute toxicity of Solanum lycopersicum Leaf. The study was designed according to the OECD guidelines as per that the dose level used as 5, 50, 300, 2000, 4000 mg/kg. Mice were orally administrated single dose of 200 and 400 mg/kg of ethanolic extract of Solanum lycopersicum. Physical, Biochemical, Hematological as well as histopathological parameters wer...
3797
1877
PREPARATION AND CHARACTERIZATION OF NANO-BIO HYBRID BASED MAGNETO LIPOSOME
The biological synthesis of magnetite nano-bio hybrid using plant extracts plays an important role in the field of nanotechnology. The present study demonstrates bio-reductive synthesis of protein coated magnetite (Fe3O4) nano-bio hybrid using leaf extracts of Datura inoxia plants and its encapsulation into liposome. Liposome is vesicles of varying size consisting of a spherical lipid bilayer and ...
3728
1511
CHARACTERIZATION AND CYTOTOXICITY EVALUATION OF SUPERPARAMAGNETIC NANOPARTICLES BIOSYNTHESIZED BY FUSARIUM OXYSPORUM SK
Superparamagnetic iron oxide nanoparticles have been used for various industrial and clinical applications. In the present study, biosynthesis of superparamagnetic Fe3O4 nanoparticles was carried out using a fungal isolate. The fungal isolate was identified as Fusarium oxysporum SK through 18S ribosomal DNA sequence analysis. The synthesized magnetic nanoparticles were subjected to Transmission El...
2817
1103
A STUDY ON PREVALENCE OF POLYCYSTIC OVARY SYNDROME AT A TERTIARY CARE HOSPITAL
The main objective of the study was to assess the prevalence of polycystic ovary syndrome at a tertiary care hospital. This study was a prospective observational study performed for a period of 6 months in infertility and gynecology clinic. For making a positive diagnosis of PCOS, all subjects were interviewed to furnish details of menstrual history including regularity, duration of cycles, and nu...
5872
1771
TRANSMISSION & LEAKAGE MEASUREMENT OF NOVEL TELECOBALT MACHINE BHABHATRON-II
The Telecobalt machines are extensively used in developing countries due to its lesser cost, lesser power consumption and easy maintenance. The high activity source can be extensively used for at least 6-8 years due to its long half-life. Installing a Telecobalt unit comprises of fixing the machine in the treatment room, ensuring its mechanical motions, source loading and all other related Quality...
5731
1771
QUALITATIVE AND QUANTITATIVE PHYTOCHEMICAL SCREENING OF DIFFERENT PLANT PARTS OF PHYLLANTHUS AMARUS SCHUM. & THONN. COLLECTED FROM CENTRAL INDIA WITH RESPECT TO THE TRADITIONAL CLAIMS FOR THEIR MEDICINAL USES
Phyllanthus amarus Schum. and Thonn. is one of the highly used medicinal plants both traditionally and scientifically. Phytochemical screening is of high importance to establish the claims of medicinal uses by traditional and folk medicine practitioners. Since, environmental, climatic and soil conditions have strong effect on production and level of particular phytochemicals in a given plant part,...
8566
2146
SEASONAL COMPARATIVE STUDY OF KANOI PAPER MILL EFFLUENT IN REFERENCE OF PHYSICO-CHEMICAL AND HEAVY METALS
In order to ascertain the degree of various pollutants in Kanoi Paper mill effluent of Bilaspur district (C.G.) India. We have taken minor research project. For attained to this purpose, we have selected eight sampling sites; Four SW and four GW sources. Collected samples (Premonsoon, Monsoon and Postmonsoon 2012) were analyzed for physico-chemical special chloride and phenolic compounds and heavy...
2933
1096
STUDIES ON EFFECT OF BREWERY WASTE WATER SLUDGE (BWS) ON MORPHOLOGY AND YIELD OF CHILLY (CAPSICUM ANNUM L.) PLANT.
In an effort to increase yields from a limited area, farmers tend to indiscriminately use more chemical fertilizers and pesticides. The brewery sludge can be directly applied to the soil for the agricultural purposes or it can be composted before utilizing for plant growth. The main objective of the present study is to test the efficacy of the bio-fertilizer in the growth and yield of Chilly Plant...
4044
1494
A VALIDATED REPORT ON FORMULATION STABILITY STUDIES OF BENDAMUSTINE HYDROCHLORIDE
The objective of this study was to adopt the analytical method. This adoption procedure was carried out by validating the method parameters and conducting the forced degradation studies to check the interference of the chromatographic response of the degradation products with the drug. In the present study an attempt was made to studies related to system suitability, linearity, accuracy, precision...
4597
0
ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF THIAZOLIDINEDIONE DERIVATIVES
The main aim of the present study was to synthesize new leads with potential antibacterial and antioxidant activities. As a part of systematic investigation of synthesis and biological activity, some of the new thiazoldinedione compounds 5a-e were prepared and screened for their antibacterial and antioxidant activities. The antibacterial evaluation of newly synthesized compounds was carried out by...
3276
1208
SYNTHESIS, SPECTRAL CHARACTERIZATION AND PHARMACEUTICAL IMPORTANCE OF NOVEL 4H-1, 4-BENZOTHIAZINES, AND THEIR SULFONE ANALOGUES
In recent years, synthesis and biological evaluation of novel 4H-1, 4-benzothiazines and their sulfone analogues have gained momentum due to their medicinal and industrial importance. The present article describes the synthesis of new 4H-1, 4-benzothiazines via condensation and oxidative cyclization of substituted 2-aminobenzenethiols with compounds containing active methylene groups. It is believ...
2690
1260
VISIBLE SPECTROSCOPIC DETERMINATION OF FAROPENEM SODIUM IN PHARMACEUTICAL DOSAGE FORM
Two simple, precise, accurate and economical visible spectrophotometric methods were developed for the determination of faropenem in bulk and in tablet dosage forms have been described. The method A was based on the formation of green color complex with Potassium ferri-cyanide in the presence of Ferric chloride, which show maximum absorbance (λ max) at 745nm.The method B is based on the reduction...
4027
1819
FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF LOPINAVIR LOADED SOLID LIPID NANOPARTICLES
Lopinavir (LPV) is potent and poorly bioavailable molecule which is frequently administered protease inhibitors in the treatment of the HIV. Solid Lipid Nanoparticles (SLNs) of LPV were prepared using High Speed Homogenization. LPV were successfully encapsulated in the mixture of Glyceryl Behenate and Glyceryl monostearate. Poloxamer 188 was used as a surfactant for the preparation of the SLNs. Fo...
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1575
EFFICACY OF MUNZIJ WA MUSHIL-E-BALGHAM (POLY HERBAL FORMULATIONS) AND MASSAGE WITH ROGHAN-E-MALKANGANI IN FALIJ NISFI (HEMIPLEGIA): A RANDOMISED CONTROLLED CLINICAL TRIAL
This study was conducted as a single blind, randomized and standard controlled clinical trial in cases of Falij Nisfi (Hemiplegia) due to ischaemic stroke. Forty eligible patients of Hemiplegia were randomized into test and control groups, comprising 20 patients in each. Test group was given Nuskha munzije balghamfor12 days, followed byNuskha Mushile Balgham, mixed with Munzije Balgham for next ...
7848
1888
A CONVENIENT SYNTHESIS AND BIOCIDAL ACTIVITY OF (N-ALKYL/ARYL SULPHONAMIDO)-4H-BENZ [d] OXAZIN-2-ONE DERIVATIVES
Compounds with a 2(H)-1, 4-benzoxazin-3(4H)-one skeleton have attached the attention of phytochemistry researchers since 2, 4-dihydroxy-(2H)-1,4-benzoxazin-3(4H) and 2,4-dihydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one were isolated from plants belonging to the Poaceae family. These compounds exihibit interesting properties11 such as phytotoxic, antimicrobial12, antifeedent, antifungal and insect...
3080
1036
MOLECULAR DOCKING OF PHYTOCHEMICAL AS FTSZ CELL DIVISION PROTEIN INHIBITOR IN MYCOBACTERIUM TUBERCULOSIS
Mycobacterium tuberculosis is the causal agent of tuberculosis which is an infectious disease responsible for more than 2 million deaths per annum worldwide, mainly in developing countries. Cell division of this microbe is very crucial for propagation. Filamenting temperature sensitive mutant Z (FtsZ) is very important player that seems to assemble into a dynamic ring (Z- ring) on the inner surfac...
3970
1727
ANTI-OXIDANT ACTIVITY OF SELECTED MEDICINAL PLANTS OF THE HIMALAYAN REGION
Natural medicines and nutraceuticals are good sources of anti-oxidant and are gaining popularity for their capacity to enhance, health-protective effects. The aim of the present study was to investigate the anti-oxidant activity of some natural medicine from the Himalayan region of Nepal. Carefully collected plant materials were subjected to maceration with methanol for about 48 hours. Anti-ox...
4419
1399
NOVEL PROPENYL FLAVONOIDS GLYCOSIDE AND ANTIOXIDANT ACTIVITY OF EGYPTIAN BAUHINIA RETUSA
Column chromatography of ethyl acetate of Bauhinia retusa afforded a novel flavonoid identified as [ rhamnetin-3-O-α- L-rhamnopyranosyl-3’-O-(prop-1-enyl)], in addition to kaempferol, isorhamnetin-3-α-rhamnoside, qurcitrin, quercetin 3-O-β-D-glucopyranosyl-β-D-glucopyranoside, and quercetin 3,7-di-o- β-D-glucoside have been isolated for the first time. Their structures were established ...
2867
1064
EFFECT OF HYDRO-ALCOHOLIC ROOT EXTRACT OF PLUMBAGO ZEYLANICA L ALONE AND ITS COMBINATION WITH AQUEOUS LEAF EXTRACT OF CAMELLIA SINENSIS ON RESERPINE INDUCED PARKINSONISM
Aim: To investigate the antiparkinsonism activity of hydro alcoholic root extract of P. zeylanica L (PZE) alone and its combination with aqueous extract of C. sinensis leaves (AECS) in reserpine induced model. Materials and methods: Parkinsonism (PD) was induced by sub cutaneous administration of reserpine (1 mg/kg) for 5 days. The extracts/drugs being tested were administered orally (p.o) 60 min ...
3132
1184
ISOLATION, PURIFICATION AND STRUCTURAL ELUCIDATION OF FLAVONOIDS FROM METHANOL EXTRACT OF ARIEL PARTS OF DERRIS BREVIPES (BENTH.) BAKER.
Two flavonoids were isolated by performing column chromatographic separation of methanol extract of ariel parts of Derris brevipes (Benth) Baker. Structural elucidation of purified compounds was done on the basis of spectral analysis using IR, 1H NMR, 13C NMR 2D NMR spectroscopy and Mass spectrometry. The structures of the flavonoids were elucidated as 2’, 4’-dihydroxy-4-methoxy-3’-prenylcha...
3710
1544