Volume 8 (2017) - Issue 9, September
Review Articles
COLEUS FORSKHOLII: PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE
Coleus forskohlii is an herb historically used in Ayurvedic medicine. Nowadays Coleus forskohlii is used as a fat burning supplement in various formulations and available in the Indian market. Forskolin the main constituent of this plant is used to treat allergies, skin conditions such as eczema and psoriasis, painful menstrual periods, irritable bowel syndrome (IBS), urinary tract infection (UTI)...
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A REVIEW OF SPECTROPHOTOMETRIC DETERMINATION OF ANTIBIOTIC NORFLOXACIN
Norfloxacin is one of the 4-quinolone antibacterials and have many applications in veterinary and human medicine. It is extensively used antibiotic among fluoroquinolone antibiotics in both human and animal welfare. Therefore, the estimation and monitoring of norfloxacin in pharmaceutical preparations and effluents has become a topic of interest for researchers and industries. Existing methods req...
5507
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A BRIEF REVIEW ON SYSTEMIC RETINOIDS
Retinoids are the derivatives of Vitamin A and have similar action to that of Vitamin A. Sources of Vitamin A such as eggs and meat are known to contain a chemical, retin-A which is known to be useful for treating various dermatological disorders. Tretinoin, a first generation retinoid was first used orally for the treatment of acne in 1940s. Topical tretinoin was later developed as a result of po...
13524
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RESVERATROL, A POTENTIAL RADIOPROTECTIVE AGENT: A MINI REVIEW
It is well known ionizing radiations produce deleterious effects on humans. In spite of research efforts for the past several years, today we do not have a radio protective agent that meets all the prerequisites like produces no cumulative and irreversible toxicity, offers effective long term protection, possess a shelf life of 2-5 years and can be easily administered. In recent years, attention h...
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APPLICATION OF QUALITY BY DESIGN TO DIFFERENT ASPECTS OF PHARMACEUTICAL TECHNOLOGIES
Quality by Design [QbD] is a science based approach widely used in industry to continually monitor and improve the quality of product. It is a modern risk based strategic framework of all the aspects related to quality. ICH guidelines Q8 to Q11 summarizes all the different perspectives of quality by design system in required depth along with ways to implement it. This review in all focuses on the ...
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A COMPREHENSIVE REVIEW ON STANDARDIZATION OF HERBAL DRUGS
In recent years more people throughout world are turning to use medicinal plant products in healthcare system. Worldwide need of alternative medicine has resulted in growth of natural product markets and interest in traditional systems of medicine. Proper integration of modern scientific techniques and traditional knowledge is important. There is a growing focus on the importance of medicinal plan...
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FACTS ON GENERIC DRUGS TO MEET OUT WORLDWIDE CHALLENGES FOR IMPLEMENTING GENERIC MEDICINE RELATED POLICIES OF HEALTH SCHEMES
Global market of generic drug has been propelled by new government initiatives to produce generic drugs and to promote the use of generic drugs; thus the use of generic pharmaceutical products represents over half of the total volume of pharmaceutical products used worldwide. India is the world’s largest exporter of cost effective generic medicines and leading Indian generic companies are genera...
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THE ANTI-ARTHRITIC POTENTIAL OF BARBADOS NUT JATROPHA CURCAS LINN. (1753) LEAF EXTRACT IN BOVINE TYPE II COLLAGEN-INDUCED ARTHRITIS IN MALE ALBINO MICE MUS MUSCULUS
In the Philippines, about 11 million suffer from arthritis. Jatropha curcas is being widely used by traditional users for treating arthritis. The study evaluated the anti-arthritic claims of J. curcas leaf extract in male albino mice with collagen type II-induced arthritis by assessing two parameters; the reduction of paw thickness due to inflammation and analysis of histopathological parameters (...
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Research Articles
EVALUATION OF ANTIBACTERIAL ACTIVITY AGAINST MULTIDRUG-RESISTANCE (MDR) BACTERIA AND ANTIOXIDANT EFFECTS OF THE ETHANOLIC EXTRACT AND FRACTIONS OF CHENOPODIUM ALBUM (SUB SP STRIATUM)
Chenopodium album (sub sp. striatum) is a folk and nutritious medicine belongs to Chenopodiaceae family and widely used as antimicrobial agent. The aim of this study is to evaluate the in vitro antibacterial potential against multidrug-resistance (MDR) bacteria isolated from clinical spicemens, antioxidant activity, total phenolic and total flavonoids content of crude ethanolic extract and nine di...
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SPECTROPHOTOMETRIC DETERMINATION OF MOLYBDENUM IN ENVIRONMENTAL AND FOOD SAMPLES USING SOLVENT EXTRACTION
2, 6-dithiol-4-methylphenol (DTMP) is proposed as an analytical reagent for the extractive spectrophotometric determination of molybdenum (V). DTMP in the presence 2, 6- bis (N, N-dimethylaminomethyl)-4-methylphenol (AP) forms red colored complex with molybdenum (V) in the pH range 4.8 - 5.8. The Beer’s law was applicable in the range 0.4-22μg mL−1. The dark red Mo-DTMP-AP complex shows...
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TOXICITY ASSESSMENT OF KEDROSTIS AFRICANA COGN: A MEDICINAL PLANT USED IN THE MANAGEMENT OF OBESITY IN SOUTH AFRICA USING BRINE SHRIMP (ARTEMIA SALINA LINN.) ASSAY
Baboon's Cucumber (Kedrostis africana (Linnaeus) Cogn is a monoecious caudiciform plant that belongs to Cucurbitaceae family. Baboon's Cucumber is used traditionally for the management of syphilis and obesity in South Africa. In the present study, we examined the hatchability and lethality of Baboon's Cucumber bulb extracts against brine shrimps. The tested samples were aqueous extract, acetone ex...
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EVALUATION OF ANTITUSSIVE AND EXPECTORANT POTENTIAL OF ZIZIPHUS MISTOL FRUITS (MISTOL)
Context: Ziziphus mistol (mistol) fruits and their derivate product (arrope) have been traditionally used as food and in folk medicine for the treatment of a wide variety of diseases including bronchopulmonary disorder. Objective: The objective of this study is to evaluate the antitussive and expectorant effects of Z. mistol ethanol extract (EE), aqueous extract (AE) and arrope (Ar). Materials and...
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF HEPATOCYTES REGENERATOR POTENTIALITY OF SOME NOVEL OXADIAZOLE DERIVATIVES FOLLOWED BY MOLECULAR DOCKING AGAINST NF-KB
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases and improper immune development. The main objective of the present research work was the synthesis of N-(4-{[5-(substituted phenyl)-1,3,4...
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MOLECULAR DOCKING STUDIES OF NOVEL IMIDAZOLE ANALOGS AS HIV-1-RT INHIBITORS
Molecular docking studies of 102 newly designed N-substituted imidazoles was performed in the non nucleoside inhibitory binding pocket of reverse transcriptase enzyme of wild type as well as resistant strains of HIV-1 virus with PDB ID 1RT2, 1JLB, 3BGR and 1FK9 respectively by using Glide 5.0 to carry out a binding mode analysis of the designed imidazoles. Results generated from this study indicat...
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EFFECT OF SINTERING CONDITION ON PHYSIO-CHEMICAL PARAMETERS AND DRUG RELEASE CHARACTERISTICS FROM POLYMERIC MATRIX TABLET OF ATENOLOL FOR CONTROLLED RELEASE
Sintering technique, a relatively new, convenient, economic process for making polymeric matrices for controlled release is described here. The objective of the present investigation was to prepare thermally sintered matrix tablets of Atenolol using Eudragit RS 100 as sintering polymer and to study the effect of thermal treatment on drug release; physiochemical properties of the prepared tablets. ...
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SOLUBILITY IMPROVEMENT OF TELMISARTAN BY COCRYSTALLIZATION WITH CITRIC ACID
Crystal engineering of cocrystals promises a new approach for the development of suitable solid phase when the solubility of API is compromised. Cocrystals are an emerging solid-state form to change physicochemical and biopharmaceutical drug properties. A cocrystal is defined as a stoichiometric hydrogen-bonded complex in the solid state between the active drug species and a suitable coformer mole...
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PREPARATION AND EVALUATION OF MUCOADHESIVE MICROSPHERE OF FLUOXETINE HCl
The aim of this research was to formulate and evaluate microspheres of Fluoxetine Hydrochloride. It is a selective inhibitor of serotonin reuptake type of drug used in the treatment of depression. It is practically soluble in water belongs to BCS class I with a bioavailability approximately 72%. Fluoxetine HCl mucoadhesive microspheres were prepared by using chitosan polymer and emulsion solvent e...
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MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING AND ANTIMICROBIAL EVALUATION OF 4-NITROCINNAMIDE ANALOGUES
A series of novel 2-Benzamido-3-(4-nitrophenyl)-N’-(substituted) benzylidene-acrylohydrazide (4a-l) analogues were designed by incorporating the few pharmacophoric fragments to enhance the activity profile of molecules. Title compounds were synthesized by the microwave irradiation of α-Benzamido-(4-nitro)-cinnamahydrazide (3) reveals with aromatic/ heteroaromatic aldehydes under acidic conditio...
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ANTI – INFLAMMATORY ACTIVITY OF EXTRACTS OF WOODFORDIA FRUTICOSA STEMS BARK IN ANIMAL MODELS
Inflammation is an inflammatory process where histamine, kinin, prostaglandins and slow release substances are produced in the tissue of the body to cause irritation or injury. It consist three phases, dilation and increased permeability of small blood vessels resulting in oedema and swelling, emigration of leucocytes from venules, capillaries and cellular infiltration, proliferation of fibroblast...
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ISOLATION, PURIFICATION AND CHARACTERIZATION OF ANTIBACTERIAL PROTEINS FROM INDUCED LARVAE OF ANTHEREAE MYLITTA DRURY (DABA TV)
Antibacterial proteins are evolutionarily ancient, effect or molecules of innate immune defense and are ubiquitously found in all kingdoms. The present study deals with the induction of antibacterial proteins in the haemolymph of Anthereae mylitta drury (Daba TV) by injecting non-pathogenic Pseudomonas DAS-01. Purified protein fraction obtained on ammonium sulphate precipitation followed by ion ex...
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FORMULATION AND IN VITRO CHARACTERIZATION OF ANTICANCER DRUG LOADED SOLID LIPID NANOPARTICLES
The aim of the study was to prepare Temozolomide loaded solid lipid nanoparticles and evaluating loaded solid lipid nanoparticles. Temozolomide loaded solid lipid nanoparticles were prepared by micro emulsification method using different lipid (stearic acid) concentration keeping drug concentration unchanged, poloxamer 188 and cetyl alcohol as surfactant and co-surfactant. The prepared SLN were ch...
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EVALUATION OF IRON OXIDE NANOPARTICLES (NPs) ON AGING AND AGE RELATED METABOLISM AND PHYSIOLOGICAL CHANGES IN C. ELEGANS
In recent decades, advances in nanoscience have resulted the rapid development of many novel technological applications for nanoparticles (NPs) in various in Biomedical Sciences. Iron is essential for eukaryotic biochemistry and is an important element in several metabolic processes such as, carrier for oxygen transportation, cell respiration, synthesis of genetic material and protein synthesis. T...
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STABILITY INDICATING ASSAY AND ESTIMATION OF IRBESARTAN BY FIRST ORDER UV DERIVATIVE SPECTROPHOTOMETRY
Introduction: Irbesartan is chemically 2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl) phenyl] phenyl} methyl) -1,3-diazaspiro [4.4] non-1-en-4-one. Irbesartan is an Angiotensin II receptor antagonist effective in the treatment of Hypertension. It is also effective in the treatment of High blood pressure. It is also effective when used alone or in combination with other drugs. Aims and Objectives:...
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EFFECT OF COMBINED MIXTURE OF FOUR MINOR MILLETS ON BLOOD GLUCOSE, SERUM LIPIDS AND OXIDATIVE STRESS IN OVARIECTOMISED WISTAR ALBINO RATS AN ANIMAL MODEL FOR MENOPAUSAL COMPLICATIONS
Diabetes mellitus, coronary artery disease and oxidative stress are some of the important complications encountered by women during menopause due to decrease in estrogen levels. Food intake has a strong impact on menopausal women and a well balanced diet is important for good health and to combat some of the complications of menopause to certain extent. Minor millets has much health benefits and h...
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THE ASSOCIATION OF DIFFERENT FUNGAL SPECIES CAUSED EPIZOOTIC ULCERATIVE SYNDROME IN FRESH WATER FISH OF CHANNA PUNCTATUS FOUND IN HASANPARTHY LAKE, TELANGANA, INDIA
Murrels are very often affected by Epizootic Ulcerative Syndrome (EUS) and it causes huge loss to the capture and culture sector. The principal infectious agent of this infestation is a fungal species, Aphanomyces invadans. Different fungal species were isolated from EUS infected Channa punctatus fish from Hasanparthy Lake of Warangal, Telangana, India. Aspergillus flavus, Fusarium solani, Rhizoph...
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CHARACTERIZATION OF ENDOGLIN GENE USING IN SILICO TOOLS
Diabetic retinopathy (DR) is a micro vascular disorder affecting the retina of the eye. Many genes have been identified for its pathogenesis. Endoglin (ENG) is one of the candidate gene involved in DR. Several literature studies helped us understand that the in vitro and in vivo studies of these candidate genes had demonstrated the role of a new gene called endoglin (ENG) capable of inhibiting ang...
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PHYTOCHEMICAL AND GC-MS ANALYSIS OF LEAF EXTRACTS OF PSEUDARTHRIA VISCIDA (LINN.) WEIGHT & ARN.
The present study elucidates the secondary metabolite profile of leaves of Pseudarthria viscida, one of the main ingredient of dasamula in Ayurveda. Alkaloids, phenolic compounds and flavonoids were estimated in different solvent-extracts. Acetone extract of leaves showed highest content of phenols and flavonoids. The leaves are quite rich in alkaloids and is found to be 1.9 mg g-1. GC-MS an...
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RISK FACTORS ASSOCIATED WITH ADVERSE DRUG REACTIONS IN HOSPITALIZED PATIENTS
Background: Understanding the association of risk factors to adverse drug reactions is very important to all healthcare professionals for the development of appropriate preventive strategies for better health care. Objectives: To identify and evaluate the risk factors associated with adverse drug reactions developed in the hospitalized patients of different departments. Methods: A prospective-retr...
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BACTERICIDAL PROPERTY OF CLERODENDRUM PANICULATUM AND SARACA ASOKA AGAINST MULTIDRUG RESISTANT BACTERIA, RESTORING THE FAITH IN HERBAL MEDICINE
Bacterial pathogens are known to pester Mankind from times immemorial; even though significant efforts in getting rid of these harmful microbes have been made the results are very faint with only few organisms that have been eradicated, such as Small pox virus. But the efforts to eradicate bacterial diseases have shown no passable results as in case of viruses. This is due to the exceptional adapt...
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FREE RADICAL SCAVENGING ACTIVITY OF FISH OIL – AN IN-VITRO STUDY
Aim and Objective: To evaluate the antioxidant property of fish oil by its free radical scavenging activity using three different antioxidant models. Materials and Methods: In vitro antioxidant activity of fish oil was evaluated by DPPH radical scavenging activity, lipid peroxidation, ABTS radical scavenging activity using olive oil as positive control. Different concentrations of the fish oil, 0....
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LOCALIZATION OF CONNEXIN 36 AND CALCITONIN GENE RELATED PEPTIDE AS A DETERMINANT OF NEUROPATHIC PAIN IN THE TRIGEMINAL GANGLION
The trigeminal ganglion consists of pseudounipolar neurons surrounded by satellite glial cells and processes innervating craniofacial region. The trigeminal ganglion consists of neurons which are of first order pseudounipolar carrying sensory pathway from the receptors from face, mouth, scalp and duramater. The gap junctions are trans-membrane proteins formed between the cell membranes of adjacent...
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MORPHOLOGICAL AND MORPHOMETRICAL STUDY OF CORONOID PROCESS IN HUMAN MANDIBLES
Background: The coronoid process of mandible is thin flat triangular process from the ramus of the mandible. This varies in the shapes and size. It gives attachment to two main muscles that is temporalis and masseter muscle. The coronoid process is the favourable donor site. A Coronoid process graft can be used for alveolar defects repair, orbital floor repair, maxillary augmentation, repair of no...
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BIOSYNTHESIS OF COPPER OXIDE NANOPARTICLES USING CYANOBACTERIA SPIRULINA PLATENSIS AND ITS ANTIBACTERIAL ACTIVITY
Recently, biological synthesis of nanoparticles (NPs) has attracted attention because of the need to develop new cost-effective and efficient synthesis protocol. In this paper, we account for the use of cell-free extract of Spirulina platensis in the biosynthesis of copper oxide nanoparticles (CuO NPs) of dimensions 30 - 40 nm. The biosynthesised CuO NPs were confirmed visually by appearance of da...
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IN VITRO EVALUATION OF ANTIBACTERIAL ACTIVITY OF LEAF EXTRACTS OF BALLOTA NIGRA AGAINST FIVE BACTERIAL PATHOGENS
Ballota nigra (Lamiaceae) has been widely used as traditional medicine in many countries for the treatment of neuro-sedative, antidepressant, antioxidant, antibacterial, insecticidal, anticholinesterase and antifeedant effects. The main objective of this study is to evaluate the antibacterial activity of leaf extracts of Ballota nigra Linn. against five bacterial pathogens. The leaves were extract...
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ROLE OF EMBLICA OFFICINALIS IN MITIGATING THE SULPHUR DIOXIDE INDUCED TOXICITY IN RATTUS NORVEGICUS (BERKENHOUT)
SO2 is considered as one of the most poisonous and irritant gas because it alters the physiology, biochemistry and behaviour of the living individuals. In the present investigation the effect of oral administration of Emblica officinalis on serum electrolyte in SO2 exposed albino rats. The thirty albino rats were grouped in three sets - control set (1) were kept in control conditions, while, rats ...
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TRADITIONAL PHYTOTHERAPEUTIC USES IN PURBA MEDINIPUR, WEST BENGAL, INDIA
The traditional health care system has been significantly used from ancient time. The rural people of Purba Medinipur, West Bengal still continue to depend on indigenous plants to cure their different types of primary health treatment. The present study explore 79 plant species belong to 41 families are systematically used in traditional health care system. Information was collected by the structu...
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A RETROSPECTIVE STUDY OF PRESCRIBING PATTERN FOR ACUTE RESPIRATORY INFECTIONS IN CHILDERN IN A TERTIARY CARE TEACHING HOSPITAL
Objective: To study prescribing pattern for acute respiratory infections in children attending outpatient department of Paediatrics, J.L.N. Hospital, Ajmer, Rajasthan. Material and Method: The study was carried out retrospectively by analyzing the copies of prescriptions of patients who had visited the O.P.D. of the paediatrics department of J.L.N. Hospital Ajmer. A total of 350 prescriptions havi...
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COMPARATIVE EVALUATION OF PATIENT’S ACCEPTABILITY BETWEEN POLYETHER AND NON – EUGENOL BASED PERIODONTAL DRESSINGS – A RANDOMISED CONTROL CLINICAL TRIAL
Periodontal dressings were widely used after flap surgery to protect the surgical site since long. This study compared polyether urethane dimethacrylate resin based Barricaid dressing and non-eugenol based periodontal dressings in the perspective of pain, esthetics and patient acceptance using a randomized split-mouth study design. Fifteen patients coming to the Department of Periodontics at ITS D...
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TO STUDY THE PRESCRIBING PATTERN OF ANALGESICS IN THE ORTHOPAEDIC IN PATIENT DEPARTMENT OF JAWAHARLAL NEHRU INSTITUTE OF MEDICAL SCIENCES (JNIMS) HOSPITAL, IMPHAL, MANIPUR, INDIA
The prescription pattern of analgesic was investigated for the months of June, July, August 2016 by studying 253 (143 male + 110 female) BHTs of in patients of the orthopaedic department. The data mainly age, sex, diagnosis and line of management available from BHTs was analysed in the form of percentage, average of variable. The generic name cost of treatment per patient and rationality of prescr...
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PULSATILE DRUG DELIVERY OF CANDESARTAN CILEXETIL FOR CARDIOVASCULAR COMPLICATIONS
The aim of current investigation was to formulate and evaluate an oral time controlled drug delivery system to achieve timed release of Candesartan cilexetil for the treatment of cardiovascular complications. Blood pressure rises early in the morning which can leads to hypertension and congestive cardiac failure. Attempt has been made to develop a drug delivery which releases the drug based on cha...
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ENCAPSULATION OF REPAGLINIDE INTO EUDRAGIT RS MICROSPHERES AND MODULATION OF THEIR RELEASE CHARACTERISTICS BY USE OF SURFACTANTS
Microspheres containing Repaglinide was prepared by emulsion solvent evaporation technique using two types of surfactants Tween 80 (polysorbate 80) and Span 80 (Sorbitanmonooleate 80). The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The release of Repaglinide from the microspheres exhibit diffusional characteristics and cl...
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DEVELOPMENT AND EVALUATION OF SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM FOR TELMISARTAN
Self nano-emulsifying system drug delivery system (SNEDDS) is promising for drugs of BCS class II. The objective of present study to develop self nano-emulsifying drug delivery system for Lipophillic drug Telmisartan (antihypertensive drug), labrafil 1944, Kolliphor ELP: Span 80 (1:1) and PEG 400: Ethanol (1:1) was chosen as oil, Surfactant and Co-surfactant as they show higher solubility for Telm...
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TUBERCULOSIS OF THE BREAST – DIAGNOSIS, MANAGEMENT, AND TREATMENT
Tuberculosis is caused by Mycobacterium tuberculosis and affects primarily the lungs. Breast tissue is remarkably resistant to tuberculosis. This is due to fact that it gives infertile environment for survival and multiplication of tubercle bacilli like skeletal muscle and spleen. The breast may become infected by variety of ways e.g. haematogenous, lymphatic, spread from contiguous structures, di...
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POTENTIAL POSITIVE EFFECT OF ORAL PYRIDOXINE ALONE AND IN COMBINATION WITH MECLIZINE ON CIGARETTES SMOKING DURING TENDAYS’ TRIAL
Purpose: Several medications are currently available for trying smoking cessation, such as nicotine replacement therapy or antidepressants. This study investigates potential effect of Meclezine-B6 combination; and B6 tablets administrated orally for possibility of reducing number of cigarettes smoked per day during 10 days. Methods: Using placebo control study. In which adult smokers' volunteers w...
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ASSESSING THE PREVALENCE OF DISABILITY AND ITS RELATIONSHIP WITH DEMOGRAPHIC CHARACTERISTICS OF THE ELDERLY IN ZAHEDAN CITY IN IRAN
Aging is among the phenomena more commonly discussed in world health in recent years. Disability is a good indicator to measure health status in the aging population. Accordingly, the primary objective of this study was to determine the prevalence of disability and its relationship with demographic characteristics of the elderly in Zahedan city in Iran in 2016. This is a cross-sectional descriptiv...
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FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF DOUBLE LAYER TABLET OF SUSTAINED RELEASE (S.R.) FLURBIPROFEN AND IMMEDIATE RELEASE DOXYCYCLINE
Purpose: To formulate and characterize the bi-layer tablet of doxycycline immediate release and flurbiprofen sustained release. Method: Bi-layer tablets were formulated by wet granulation method. Ethyl cellulose and HPMC K 100 were used as polymer for sustained release layer. Five immediate release formulations were developed with varying excipients. Bi-layer tablets were evaluated by pre formulat...
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QUASI-EXPERIMENTAL STUDY OF THE EFFECT OF PATIENT COUNSELING ON QUALITY OF LIFE AMONG TUBERCULOSIS PATIENTS
Objectives: Tuberculosis (TB) remains one of the most substantial infectious causes of death in the world. Studies focusing on the quality of life (QOL) among TB patients are limited and the effect of counselling on patients QOL has not been well-studied. The aim of this study was to assess the effect of patient counselling on QOL among patients with Tuberculosis. Methods: A quasi-experimental stu...
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THE RISK OF HYPERGLYCEMIA ASSOCIATED WITH THE USE OF PRESCRIBED MEDICATIONS
Hyperglycemia is a deleterious consequence of uncontrolled diabetes and an adverse effect of many common therapeutic drugs. Identification of drug-induced hyperglycemia is necessary for reducing morbidity or mortality associated with high blood glucose levels. The aim of the present study was to assess risk of unrecognized drug-induced hyperglycemia in patients admitted to King Abdulaziz Medical C...
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HPTLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF OXYCLOZANIDE AND LEVAMISOLE HYDROCHLORIDE IN TABLET DOSAGE FORM
This paper describes a new, simple, precise, and accurate HPTLC method for simultaneous estimation of Oxyclozanide and Levamisole hydrochloride as the bulk drug and in tablet dosage forms. Chromatographic separation of the drugs was performed on aluminium plates pre-coated with silica gel 60 F254 as the stationary phase and the solvent system consisted of Toluene: acetone: ammonia (5:5:0.04 v/v/v)...
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DEVELOPMENT OF A POLYHERBAL CAPSULE FOR THE TREATMENT OF ASTHMA
A drug dosage form is very important in delivering the drug in proper dose in most appropriate form. The capsule shell is an excellent barrier to air, and it also has some other advantages such as being easy to swallow and tasteless, flexibility of formulation etc. The use of the hard gelatin capsule dosage form may perhaps be an alternative to overcome the problem, which the hygroscopicity of the...
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GC-MS ANALYSIS, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF THE BROWN ALGAE, PADINA TETRASTROMATICA
Marine algae are one of the largest sources for biogenic compounds. They produce a wide variety of chemically active metabolites. They are found to possess significant antioxidant, and phytochemical activities. Macroalgae provides a great variety of metabolites and natural bioactive compounds with antimicrobial activity, such as polysaccharides, polyunsaturated fatty acids, phlorotannins and other...
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MICROWAVE IRRADIATED SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF 3-((SUBSTITUTED-BENZO[D]THIAZOL-2-YLAMINO)METHYL)-5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOLE-2(3H)-THIONE
A series of new Mannich base derivatives were designed, synthesized by conventional and non-conventional microwave method, compared and evaluated for their antimicrobial and anti-mycobacterial activity. Structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral studies. The bioactive assay showed that Mannich base derivativ...
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