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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 13 (2022) - Issue 1, January

Review Articles

 
Title
Views
PDF
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01.

BIOMEDICAL APPLICATION OF NANOFORMULATED PLANT

An extensive range of studies have shown plant extracts and their phyto-constituents efficacy, proposing them as a promising alternative for treatment or as adjuvants in human diseases such in skin, gastrointestinal, systemic and dental conditions, due to various active components presence, ease of access and reduced side effects. Indeed, depending on solvent used to obtain the extract, its active...

M. S. Heya, P. L. García-Coronado, A. Cordero-Díaz, A. D. Torres-Hernández and O. A. Pérez-Narváez *

Department of Chemistry, Laboratory of Analytical Chemistry, Facultad de CienciasBiológicas de la Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León, CP. 66455, México.

DOI: 10.13040/IJPSR.0975-8232.13(1).1-12

01-12

941

732

02.

EUPHORBIA HIRTA LINN. – AN INVASIVE PLANT: A REVIEW OF ITS TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES

Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed with the aim to compile updated information on E. hirta including its medicinal us...

Amrendra Nath Tripathi *, Suresh Chandra Sati and Parikshit Kumar

Department of Botany, D.S.B. Campus, Kumaun University, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).13-24

13-24

743

449

03.

ROLE OF VITAMIN D IN CARDIOMETABOLIC DISORDERS – A REVIEW BASED ON PATHOPHYSIOLOGY AND CLINICAL EVIDENCES

Background: Cardiometabolic syndromes are the co-occurrence of metabolic abnormalities such as obesity, insulin resistance, atherogenic dyslipidemia, and hypertension. Cardiometabolic disorders includes type2 diabetes mellitus, metabolic syndrome, and cardiovascular diseases. The prevalence of cardiometabolic disorders are growing in epidemic proportions all over the world; hence cardiometabolic d...

D. Basu and A. A. Mehta *

L. M. College of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).25-32

25-32

594

303

04.

AN OVERVIEW: MEDICINALLY IMPORTANT HETEROCYCLIC MOIETY BENZOTRIAZOLE

In organic chemistry, the largest families of organic compounds belong in the heterocyclic compounds. In our daily life, the importance of heterocyclic compounds is very essential. It has a broad range of applications in medicinal chemistry. Benzotriazole is a bicyclic heterocyclic system consisting of three nitrogen atoms and a fused benzene ring, shows wide range of biological and pharmacologica...

Hasit V. Vaghani *, Sarika P. Patel and Shweta A. Patel

Mehsana Urban Institute of Sciences, Ganpat Unversity, Kherva, Mehsana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).33-41

33-41

625

249

05.

MICROSPONGES: A PROMISING APPROACH FOR DRUG DELIVERY

Micro sponges are patented polymeric drug delivery systems consisting of porous microspheres. The physical appearance of microsponges is tiny spherical sponge-like with the surface with large spores. Micro sponges are typically used and nowadays used as the oral dosage form. The inert and indestructible tiny spherical particles do not pass through the skin. But, it collects in the tiny nooks and c...

Ranu Biswas *, Sayani Saha, Chayanika Chatterjee and Samrat Ghosh

BCDA College of Pharmacy & Technology, Jessore Road, Hridaypur, Barasat, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).42-49

42-49

735

303

06.

QUALITY BY DESIGN: A PRE-REQUISITE FOR PHARMACEUTICAL DEVELOPMENT

Quality by Design (QbD) is an essential part of modern pharmaceutical development. QbD is a requisite for the design and development process for the pharmaceutical industry. QbD assists and encourages both the industries and FDA to inculcate a proactive, scientific and risk-based approach in the process and product development. It is based on a concept of building quality right from the start of t...

Shweta Singh *, Sudha Rathod, Randeep Saini and Reshma Shaikh

Department of Pharmaceutics Oriental College of Pharmacy, Sanpada, Navi Mumbai (Affiliated to the University of Mumbai) Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).50-60

50-60

639

263

07.

MODERN ANALYTICAL TOOLS FOR THE DETERMINATION OF THE ACTIVE PHARMACEUTICAL INGREDIENTS: A REVIEW

Discovery of the drug molecule which has therapeutic values is the backbone of drug development. Pharmaceuticals have an important role in the prevention and treatment of diseases in humans and animals. However, gradual change in the process of drug synthesis from drug development to bulk production is a common complication in the drug development process. This change may result in the formation o...

A. Chavan and R. Gandhimathi *

Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).61-69

61-69

510

199

08.

A MINI REVIEW ON ADVANCES IN TRANSDERMAL DRUG DELIVERY SYSTEM

Currently, oral drug delivery and parenteral drug delivery are used for the treatment of various diseases. In the oral drug delivery system, due to the first-pass metabolism and acidic environment of the gastrointestinal route, the drug exposes to acids and enzymes present in the gastrointestinal tract, which may lead to degradation of the compound, which ultimately results in poor bioavailability...

Avinash R. Tekade * and Prasad Y. Kolapkar

Department of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Thergaon, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).70-85

70-85

561

240

09.

CHRONOTHERAPEUTIC SYSTEMS: NOVEL SYSTEMS OF DRUG DELIVERY

Chronotherapeutic systems are meant for the treatment of most of the diseases that occurred and found till date, which are proved to be in association with the biological/circadian rhythms of our body with respect to disease symptoms and their severity. Such diseases use this treatment as it involves in-vivo drug availability with distinctive release patterns so as to match the rhythms of disease ...

Santosh Kumar Rada * and Shambhavi Kandukuri

Department of Pharmaceutics, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Vishakhapatnam , Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).86-94

86-94

358

220

10.

CRYONICS: A REVIEW

Tissues can be preserved for centuries under the conditions of extremely cold temperatures along with the neurological functions of the human brain. It is possible with the process of vitrification; here the cells of the brain are cooled to the cryogenic temperature without the formation of ice. Damage caused due to this process is theoretically reversible as like before, but practically, rejuvena...

Pavankumar Krosuri *, K. Madhavi, J. Sunayana and M. Sai Ganesh

Department of Pharmaceutics, Santhiram College of Pharmacy, Nandyal, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).95-100

95-100

868

282

11.

LIPID POLYMER-BASED BIO-INSPIRED DRUG DELIVERY SYSTEM

Gene targeting has been a promising drug delivery system, thereby helping to improve the impaired functioning in various disorders. "Lipoplexes" and "Polyplexes" incorporates lipids and polymers combined with bioactive molecules, drugs, or genes are one of the newly developing systems. The need to protect genes from degradation, allowing them to reach their target site and to promote an efficient ...

Riddhi Ahuja and Meenal. M. Rane *

SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Gate No. 1, Mithibai College Campus, V.M. Road, Navpada, Suvarna Nagar, Vile Parle (West), Mumbai , Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).101-17

101-117

469

201

12.

ANIMAL MODELS OF CHEMICAL-INDUCED ALZHEIMER’S DISEASE: AN OVERVIEW

Characteristics like dementia, behavioural and cognitive dysfunction, and memory decline may characterize Alzheimer's disease (AD). A deterioration of short-term memory, inability to acknowledge new information, mood swings, difficulty recognizing words, forgetting names, and losing things are demonstrated by early disease. Popular emotional characteristics displayed by patients with AD are anger,...

Rashda Khatoon, Vanita G. Kanase *, Abhaykumar Yadav, Nitesh Gupta, Shivam Varma and Sayali Shete

Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).118-24

118-124

612

295

13.

COMPARISON OF THREE TECHNIQUES FOR THE DIAGNOSIS OF MALARIA IN RESOURCE-LIMITED SETTINGS: A MINI-REVIEW

Objective of this article is to review three techniques, routinely used rapid diagnostic tests (lateral flow immune chromatography) versus nucleic acid amplification test (NAT) versus Paper-based microfluidics for DNA diagnostics of Malaria, as diagnostic tests in detecting malarial infection among febrile illnesses, suspected of malaria. The major constraint for implementing NAT as a routine scre...

Neha Martin Honnalli and T. M. Desy *

Department of Biochemistry, KS Hegde Medical Academy, Nitte - DU, Mangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).125-29

125-129

321

146

14.

CAUSES, DIAGNOSIS AND MANAGEMENT OF MALE INFERTILITY: PHYTOCOMPOUNDS AS NATURAL SERMs- A REVIEW

Infertility is an inability to achieve pregnancy in spite of regular, unprotected coitus in one year. Infertility affects about 15% of couples, in which the malefactor contributes to 40% worldwide. There are various risk factors, causes, and treatment modalities for male infertility, of which Selective Estrogen receptor modulators (SERMs) are one of the promising treatments available for treating ...

Nithya Sethumadhavan

Department of Biotechnology, Biochemistry and Bioinformatics, Avinashilingam Institute of Home Science and Higher Education for Women, Bharathi park road, Tatabad, Forest College Campus, Saibaba Colony, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).130-38

130-138

437

198

15.

COVID19: PATHOPHYSIOLOGY, CLINICAL FEATURES, DIAGNOSIS AND MANAGEMENT

SARS-CoV-2 viral cause infection called COVID-19 was initially reported in China has resulted in a pandemic because it has spread in over 210 countries. This review summarized pathophysiology, clinical features, diagnosis, and COVID 19. The spread of SARS-CoV-2 viral infections is a matter of concern because of a mutant variant of virus. The COVID-19 infection is having 14 days incubation period. ...

J. Bhumika Patel, S. Usha Lalwani and B. Mukeshkumar Vora *

Department of Pharmacology, GMERS Medical College & Civil Hospital, Sola, Ahmedabad , Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).139-51

139-151

587

284

16.

AN INTELLIGENT DATA ANALYTICS SYSTEM FOR THERAPEUTIC OF ANGINA PECTORIS IN CARDIOVASCULAR DISEASE MANAGEMENT: A MODEL METHODOLOGY

Medical Case taking process in any field of medicine science is considered to be a significant stage for the treatment management of various diseases. Cardio Vascular diseases (CVD) are one of the life-threatening diseases across the globe, and its prognosis entirely depends on the right intuition of the clinicians; cases may account for 31% of deaths worldwide, based on a recent study. Big Data M...

Chandan Pan, Debasmita Chatterjee *, Ajoy Kumar Ray, Shubabrata Sinha, Rathin Chakravarty, Satadal Das and Krishnendu Paira

Heritage Institute of Technology, Chowbaga Road, Anandapur, East Kolkata Townshio, Kolkata, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).152-63

152-163

415

236

Research Articles

 
Title
Views
PDF
Cited
17.

ANTI-DIABETIC AND OXIDATIVE STRESS MARKERS IN MEN WITH TYPE 2 DIABETES MELLITUS

The aim of this study is to evaluate metformin and insulin effects on metabolic disorders and oxydatif stress markers, in Algerian men with T2D, in order to recommend the best treatment, which can minimize diabetes complications and recommend/or not a combination between metformin and insulin. Patients and Methods: We made this study on 120 subjects men divided into four groups (30 healthy control...

Hasnia Rabehi, Baya Guermouche *, Hafida Merzouk, Majda Dali-Sahi and Sid Ahmed Merzouk

Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-BekrBelkaïd University, Algeria.

DOI: 10.13040/IJPSR.0975-8232.13(1).164-72

164-172

904

340

18.

CHARACTERIZATION OF BIOACTIVE METABOLITES FROM MARINE MACROALGAE COLLECTED FROM VERAVAL COAST OF GUJARAT

Seaweeds are potential sources of bioactive molecules. They are known to be rich sources of proteins, carbohydrates, lipids, vitamins, minerals, and other secondary metabolites. To evaluate the presence of these compounds in marine macroalgae collected from Veraval coast of Gujarat, present studies was carried out. The methanol extract of six macroalgae species (Ulva lactuca, Ulva faciata, Acantho...

Hiral P. Goswami, Jigna G. Tank * and Rohan V. Pandya

UGC-CAS Department of Biosciences, Saurashtra University, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).173-80

173-180

548

291

19.

FORMULATION AND EVALUATION OF ANTI-AGING CREAM USING BANANA PEEL EXTRACT

Topical formulations may contribute to the reduction of oxidative stress in the skin. Banana peel is a fruit waste with antioxidant activity that is not yet included in a topical formulation. The aim of this study was to evaluate the antioxidant and anti-aging activity of a cream formulation containing a lyophilized extract of banana peel. The banana peel was extracted with ethanol, and a cream fo...

F. Uckaya * and M. Uckaya

Department of Nursing *, Faculty of Health Science, Alanya Alaaddin Keykubat University, Antalya, Turkey.

DOI: 10.13040/IJPSR.0975-8232.1.(1). 181-91

181-191

1171

619

20.

SYNTHESIS OF NOVEL SCHIFF’S BASES AND THEIR BIOLOGICAL ACTIVITIES

A new series of Schiff's base compounds were synthesized by condensation of 1-(4-amino-4 phenyl) 3-phenyl triazene-1-ol) and substituted aldehyde and gave high yields of target compounds. Antimicrobial activity of compounds has been tested against bacterial and fungal species, namely gram-positive bacteria as S. aureus and S. pyogenes, gram-negative bacteria as E. coli and P. aeruginosa, and funga...

Arvind Singh Shekhawat, Narendrapal Singh Chauhan, Girdharpal Singh and Narendra Singh Chundawat *

Department of Chemistry, Faculty of Science, Bhupal Nobles’ University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).192-96

192-196

754

258

21.

INFLUENCE OF DIFFERENT SOLVENTS ON ANTIBACTERIAL POTENTIAL OF THREE SPECIES OF HIMALAYAN OAKS

The antibacterial property of three Himalayan Oaks species (Quercus floribunda, Q. leucotrichophora and Q. semecarpifolia) in different solvents against eight gram-positive and gram-negative pathogenic bacteria employing disc diffusion method has been investigated. All the test microorganisms were inhibited significantly by Oaks species at 1000 μg/ml. The MIC and MBC values of each extract (where...

Suresh Chandra Sati, Amrendra Nath Tripathi * and Parikshit Kumar

Department of Botany, D.S.B. Campus, Kumaun University, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).197-05

197-205

451

239

22.

AMELIORATION OF 131I INDUCED SALIVARY GLAND DAMAGE BY OCIMUM SANCTUM AND AMIFOSTINE PRE SUPPLEMENTATION IN RABBITS

Oral administration of 131I to the patients of differentiated thyroid cancer is routinely used to ablate remnant thyroid tissue or metastasis. In 30% of the patients, permanent salivary gland damage due to therapeutic 131I exposure results in xerostomia, affecting their quality of life. Amifostine is the only standard FDA-approved radio protect ant available for damage control, albeit associated w...

U. Bhartiya *, Y. Pawar, L. Joseph, Y. Raut, D’ Souza S., D. Singh, S. Awasare, Y. Nayak, R. Hawaldar and S. Banerjee

Radiation Medicine Centre *, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).206-14

206-214

313

160

23.

A RETROSPECTIVE AUDIT OF DRUG PRESCRIBING PATTERNS AMONG THE PATIENTS VISITED THE DENTAL CLINIC OF A PRIVATE MEDICAL UNIVERSITY IN KEDAH, MALAYSIA

Introduction: Irrational use of drugs is widespread in present-day medical practice. Hence, the present study aimed to analyze the drug prescribing pattern among the patients who visited the Faculty of Dentistry dental clinic, AIMST University. Methods: A retrospective, cross-sectional study was conducted to analyze the drug prescribing pattern of dentists of AIMST University, Kedah, Malaysia. A t...

Dinesh Kumar Upadhyay *, Gun Irene Ching, Praveen Bhoopathi and Sonam Pandey

Faculty of Pharmacy, AIMST University, Jalan Bedong-Semeling, Bedong.

DOI: 10.13040/IJPSR.0975-8232.13(1).215-20

215-220

367

189

24.

TAU-PET IMAGING OF BRAIN DAMAGE IN HEAD INJURY

Positron emission tomography (PET) imaging has been broadly used in the study of brain damage for a long time. However, PET has been mostly used for the assessment and detection of neural activity after brain damage. Tau proteins play a significant role in a variety of degenerative neurological conditions. Post-mortem neuropathology studies of victims of repeated and severe head trauma have define...

Seyyed Hossein Hassanpour, Seyyedeh Zeinab Karami and Alireza Doroudi *

Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

DOI: 10.13040/IJPSR.0975-8232.13(1).221-28

221-228

331

157

25.

A STUDY ON “SANJEEVANI” (S. BRYOPTERIS) IN COMPARISON WITH ITS MARKET ADULTERANT S. INVOLVENS

Many species of the genus Selaginella P. Bauev. (family: Selaginellaceae) are used as traditional medicine. In India, S. involvens (Sw.) Spring and S. bryopteris (L) Bak are used for medical purposes. In some works, these two species have been treated as resurrection plants or ‘Sanjeevani’. These plants have considerable morphological similarity which can create confusion regarding the exact p...

P. Nisha * and M. Rafiya

Department of Botany, St. Xavier’s College for Women, Aluva, Ernakulam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).229-35

229-235

315

157

26.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF GLIPIZIDE AND MOMORDICININ IN RAT PLASMA

Momordicinin (MMR) is a major triterpenoid compound from Momordica charantia Linn fruit having antidiabetic potential, whereas glipizide (GPZ) is a well-known molecule in treatment of diabetes mellitus. The primary objective of the study is to develop and validate a simultaneous RP-HPLC method for upcoming pharmacokinetic studies to analyze herb-drug interactions. The study uses the protein precip...

Akshay Ingle, Prajakta Kulkarni and L. Sathiyanarayanan *

Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University) Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).236-41

236-241

339

167

27.

EVALUATION OF HYDROCHLOROTHIAZIDE AND METHYLDOPA SIMULTANEOUSLY BY APPLYING CHEMOMETRIC SPECTROPHOTOMETRIC METHOD

In the present work, simultaneous estimation of Hydrochlorothiazide and Methyldopa was carried out by applying chemometric assisted UV spectro-photometric methods. The Two chemometric methods, classical least square (CLS) and inverse least square (ILS) were applied for estimation of Hydrochlorothiazide and Methyldopa simultaneously in tablets without any prior separation, and no graphical treatmen...

Madhuri A. Hinge * and Dipti Patel

Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat Vidyanagar, Mehsana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).242-50

242-250

315

156

28.

ANTIMICROBIAL ACTIVITY OF LEAVES OF FICUS BENGHALENSIS AGAINST ISOLATED DENTAL PATHOGENS

Dental caries is considered one of the major oral health issues throughout the world. Synthetic drugs and antibiotics have major side effects and can develop resistance. Ficus benghalensis F. benghalensis is a plant with enormous established pharmaceutical properties. The present study was designed to evaluate the antimicrobial activity of water, and ethanolic extracts of F. Benghalensis leaves ag...

Anbu Jeba Sunilson John Samuel *, Anita Gnana Kumari Anpumoni Vimala and Dhanuprabha Dakshanamurthy

Department of Siddha Medicine, Tamil University, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).251-56

251-256

492

184

29.

ESTIMATION OF FOSTEMSAVIR USING A NOVEL HPLC ANALYTICAL METHOD

Fostemsavir was quantified using a simple and reliable HPLC technique developed and validated. PhenomenexC18 column was used to achieve chromatographic segregation (150 x 4.6 mm, 5m). The mobile phase was a 55:45 mixture of 0.01N disodium orthophosphate and acetonitrile pumped through the column at 1.0ml/min. The temperature was maintained at 30 °C and the buffer used was 0.01N sodium dihydrogen ...

Rashnita Sharma * and C. Asha Deepti

Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).257-65

257-265

446

272

30.

DEVELOPMENT OF HERBAL NANO EXTERNAL FORMULATION AS OINTMENT WITH URENA LOBATA EXTRACT AND VALIDATION OF ITS WOUND HEALING ACTIVITY IN EXPERIMENTALLY INDUCED OPEN WOUNDS IN SWISS ALBINO RATS

Urena lobata is used by traditional practitioners for treating external wounds. A preclinical study was conducted to evaluate the efficacy of the ointment formulations containing ethanolic extract of Urena lobata (EO) (5%) and nanosized extract (NO) of U. lobata (5%) for their wound healing activity by assessing wound contraction, tensile strength, superoxide dismutase, catalase, reduced glutathio...

Thirumalaikumaran Rathinam *, Chamundeeswari Duraipandian and Sivakumar Vijayaraghavalu

School of Pharmacy, Sathyabama Institute of Science and Technology (Deemed to be University), Jeppiar Nagar, Semmanchery, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).266-76

266-276

368

174

31.

PRECLINICAL STUDY ON URINARY TRACT INFECTED EXPERIMENTAL RATS TREATED SPHAERANTHUS INDICUS L.

A model of ascending Urinary tract infection (UTI) in rats was developed to study the significance of antibacterial activity of Sphaeranthus indicus L. and compared with standard antibiotic ofloxacin as a positive control. This plant used in folk medicine as a remedy for urinary tract infections is belong to Asteraceae family. Outbred female wistar rats were used throughout the study and Escherich...

Jagruti S. Rana * and M. N. Reddy

Vidhyadeep Institute of Science College Kim *, Anita Olpad Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(1) 277-82

277-282

327

157

32.

QUALITATIVE AND QUANTITATIVE ANALYSIS OF PHYTOCHEMICALS AND EVALUATION OF IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF THREE SELECTED AYURVEDIC MEDICINAL PLANTS USED IN RHEUMATOID ARTHRITIS MEDICATIONS

This research was focused on the qualitative and quantitative analysis of phytochemicals and evaluation of in-vitro antioxidant and anti-inflammatory activities of three commonly used plant parts in rheumatoid arthritis medications in Ayurveda, namely, the root of Boehmeria nivea, the barks of Gmelina arborea and Oroxylum indicum, using standard methods. Qualitative analysis of each methanol extra...

S. C. Senarathna and I. R. Fernando *

Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

DOI: 10.13040/IJPSR.0975-8232.13(1).283-90

283-290

369

204

33.

IN-VITRO ANTILEISHMANIAL EVALUATION OF AMPHOTERICIN B-MILTEFOSINE NANOVESICLES

Leishmaniasis is a neglected tropical infectious disease affecting poor people, especially in the developing countries of the world. It is a systemic disease caused by a protozoan parasite leishmania donovani and is fatal if left untreated. The aim of the present study is to develop and evaluate the in-vitro antileishmanial activity of the combination of amphotericin B and mitefosinenano vesicles ...

Mulugeta F. Bezabeh *, Karl A. Werbovetz and K. V. Ramana Murthy

College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).291-01

291-301

345

160

34.

INFLUENCE OF LORNOXICAM ON HYPOGLYCEMIC POTENTIAL OF SOME ORAL HYPOGLYCEMIC AGENTS IN NORMAL AND DIABETIC RATS

Objective: The objective was to study drug-drug interaction between Lornoxicam and oral hypoglycemic agents in normal and Streptozotocin-induced diabetes in rats. Material and Method: The protocol was blueprinted in two phases. In the first segment, the influence of Glibenclamide (0.7mg/kg/p.o.) and Glipizide (1.05mg/kg/p.o.) once daily on blood glucose levels in normoglycemic rats were studied ...

Vaibhav P. Uplanchiwar *, Sachin M. Hiradeve, Vijendra B. Fulzele, Mohammad Hashim Mansoori and Hritwik Jain

School of Pharmacy, GH Raisoni University, Saikheda, Chhindwara, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).302-08

302-308

307

141

35.

RADIOLOGICAL AND GENE-EXPERT PATTERN: IN RELATION WITH TREATMENT OUTCOME OF SENSITIVE AND RESISTANT TUBERCULOSIS

Even if there are so many diagnostic tests available for the detection of tuberculosis, still the diagnosis of TB is a challenging problem in this decade due to differences or non-specificity in symptoms, radiological signs, false negatives, and positives. Chest X-ray can identify the location, area, and morphology of lesions; hence analyzed the pattern and relation of chest X-ray and Gene expert ...

Johnson V. Babu, Joicy Jose, Leya P. Babu, Nimmy Robin and Shaji George *

Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).309-15

309-315

319

183

36.

HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF ABROMA AUGUSTA AGAINST NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN SD RATS

To study the hepatoprotective activity of ethanolic leaves extracts of Abroma augusta against non-alcoholic fatty liver disease to validate ethnobotanical claim regarding the plant used in the above mentioned disease. Materials and Methods: The hepatoprotective potential of Abroma augusta leaves extract (AALE) (250 and 500 mg/kg/ body weight) was studied on Methionine and Choline deficient diet (M...

K. Anil Yadav * and Anoop Singh

Institute of Pharmacy, Pranveer Singh Institute of Technology (PSIT), Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).316-26

316-326

463

219

37.

TARGET-BASED APPROACH FOR IN SILICO STUDIES, DESIGN, SYNTHESIS, AND ANTIULCEROGENIC POTENTIAL OF NOVEL 1,4 DIHYDROPYRIDINE DERIVATIVES

In-silico studies play a very crucial role in medicinal chemistry and synthesis of the lead compound. As we know that 1,4-Dihydropyridine is a versatile molecule, and previous studies have shown that it possesses therapeutic activity in different diseases, such as anticancer, anticonvulsant, anticoagulant, anti-Alzheimer, antitubercular antiulcer. As described by the researchers, 1,4 Dihydropyridi...

Abhinav Prasoon Mishra * and Rakesh Kumar Meel

Department of Pharmacy, Advance Institute of Biotech and Paramedical Sciences, Naramau, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1) 327-44

327-344

302

169

38.

A STUDY ON THE ADVERSE DRUG REACTIONS OF HIV-TB CO-INFECTED PATIENTS IN A TERTIARY CARE HOSPITAL OF NORTH EAST INDIA – A PROSPECTIVE COHORT STUDY

The reporting of adverse drug reactions after taking any medicines is very much essential to establish a safe patient profile for drugs. The co-infection of HIV and TB has been a major concern for the healthcare system, and the various drugs interaction from taking ART and ATT should be highlighted to avoid unwanted reactions. The present study was conducted in a hospital set up for a period of on...

P. Bordoloi, U. Choudhury, K. N. Dutta, L. Nath * and B. J. Sahariah

NETES Institute of Pharmaceutical Science, Nemcare Group of Institutions, Mirza, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).345-50

345-350

346

171

39.

AN EXPERIMENTAL STUDY TO EVALUATE THE EFFECT OF TRANDOLAPRIL AND NIMODIPINE IN ANXIETY, DEPRESSION AND MOTOR COORDINATION USING BEHAVIORAL MODELS IN SWISS ALBINO MICE

The present study aimed to assess the role of  angiotensin-converting enzyme inhibitor (trandolapril)  and calcium channel blocker (nimodipine) in anxiety, depression, and motor coordination using behavioral models in mice. This was an experimental study involving 72 swiss albino mice divided into 12 groups. Groups 1 to 4 were used to evaluate the anxiolytic effect using Y maze after 5 days of t...

Sayed Shakita Fatima *, Rishi Pal, DA Rizvi, A. Singh, F. Asif, S. Hasan, R. Nath, A. K. Sachan and R. K. Dixit

Department of Pharmacology and Therapeutics, King Georges Medical University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).351-58

351-358

325

170

40.

APPLICATION OF THE INFORMATION TECHNOLOGIES IN EARLY PREDICTING THE SEVERITY OF ATOPIC DERMATITIS IN CHILDREN

The application of mathematically based prognostic software is a rational and promising approach to determining disease prognoses. In our research, we identified indicators as prognostic criteria for the development of atopic dermatitis (AD). Our research involved 260 healthy children and 268 newborns with AD. To select the risk factors for predicting the formation of AD, initially, variation and ...

N. N. Hajiyeva * and İ. A. Gafarov

Azerbaijan Medical University, Department II of Children’s Diseases, Baku, Azerbaijan.

DOI: 10.13040/IJPSR.0975-8232.13(1).359-68

359-368

328

145

41.

HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY OF MORINGA OLEIFERA LEAF POWDER IN ALLOXAN-INDUCED DIABETIC RABBITS

The present study was carried out to investigate the hypoglycemic and hypolipidemic effect of Moringa oleifera leaf powder (MO) in alloxan-induced diabetic rabbits by administering oral doses (100, 200, and 400 mg/kg body weight). Diabetes was induced intravenously into rabbits with a single dose of alloxan (150 mg/kg). Diabetic rabbits were treated with MO (100, 200, and 400 mg/kg) and Glibenclam...

Krishnaveni Bommineni * and Madhusudhan Rao Yamsani

Department of Pharmacognosy, Vaagdevi College of Pharmacy, Kishanpura, Kakatiya University, Hanamkonda, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).369-74

369-374

324

183

42.

FORMULATION AND EVALUATION OF ORAL ANTI-DIABETIC IN-SITU GEL SYSTEM OF PIOGLITAZONE

Pioglitazone is an oral anti-diabetic agent used in treating class – II diabetes mellitus. T1/2of pioglitazone was 3-6 hrs and is eliminated rapidly. Hence sustained release is needed to prolong its duration of action and to increase its oral bioavailability. The study's main aim was formulation and evaluation of an in-situ gel system of pioglitazone to increase its bioavailability as a convenie...

B. Padmasri * and R. Nagaraju

Department of Pharmaceutical Technology, Sri Venkateswara College of Pharmacy, Etherla, Srikakulam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).375-83

375-383

358

175

43.

CLINICAL DIAGNOSIS AND SAFETY OF VILDAGLIPTIN VERSUS GLIMEPIRIDE WITH METFORMIN OVER PATIENTS OF TYPE-2 DIABETES MELLITUS

The aim of the study to compare the efficacy of vildagliptin (50 mg) and glimepiride (2 mg) metformin (500 mg) for type-2 diabetes mellitus. Vildagliptin and glimepiride are found to be regulated the blood plasma glucose by stimulating beta cell in the pancreas. The treatment course duration of 34 weeks comparative observational study was conducted over 160 patients with type-2 diabetes mellitus w...

Praveen Yadav, Bhaskar Joshi and A. Geetha Bhavani *

Department of Chemistry, Noida International University Research Innovation Centre, Noida International University, Gautama Buddha Nagar, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).384-91

384-391

442

207

44.

IN-SILICO DESIGN AND COMPUTATIONAL STUDY OF NOVEL QUINAZOLIN-4-ONE DERIVATIVES AS POTENTIAL AFFINITY WITH EGFR FOR ANTICANCER ACTIVITY

Molecular object precise healing designed for the malignancy be unrelated as of the predictable therapy, as well as radio healing in conditions of selectivity and specificity target to the malignant tyrosine kinase, is well-thought-out additional shows potential molecular intention for invention and expansion of the new cytotoxic drug molecules. Epidermal growth factor receptor is overexpression i...

N. Srinivasan, K. Kavitha *, S. Mohan and R. Suresh

Department of Pharmaceutical Chemistry, Karpagam College of Pharmacy, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).392-02

392-402

349

199

45.

PROTECTIVE ACTIVITY OF THE METHANOLIC EXTRACT AND ITS SOLVENT FRACTIONS OF THE FRUITS OF SOLANUM NIGRUM (MAKO) ON GENTAMICIN-INDUCED NEPHROTOXICITY IN ALBINO RATS

Objective: Mako (Solanum nigrum L.), Black Nightshade in English, belongs to the family Solanaceae is an edible plant. The whole plant is used as a green source of vegetables and berries as a fruit. It is a good source of antioxidant and has potent anti-inflammatory, diuretic, lithotriptic, wound healing properties. Unani scholars have advocated the berries to treat many renal ailments, including ...

Mohd Aslam, Mohamed Shiffa * and Nazeem Fahamiya

Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).403-08

403-408

324

164

46.

GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF HUGONIA MYSTAX LEAVES

Hugonia mystax is a woody evergreen plant that grows in the dry forest areas of India and Sri Lanka. Often found in the forests of Kerala and Tamil Nadu in southern India. It is locally known as modirakanni (tamil) and kamsamaraha and tribals from Tamil Nadu, India, have used it in primary health care. The plant parts are used ethnobotanically to treat rheumatism, skin diseases and inflammations, ...

B. Vasuki *, P. Chitra, M. Vijayabaskaran, N. Mahadevan and R. Sambathkumar

Department of Pharmaceutical Chemistry, J. K. K. Nattraja College of Pharmacy, Kumarapalayam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).409-16

409-416

338

163

47.

PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF EXTRACTS OF AZADIRACHTA INDICA A. JUSS (MELIACEAE) (CÔTE D’IVOIRE)

The purposes assigned to this work are the phytochemical screening of certain phytoconstituents, the estimation of the antioxidant and antibacterial activities of extracts of Azadirachta indica A. Juss. The selective extracts obtained from the aqueous decocts were used to establish the chromatographic profile of the various extracts. As for the crude aqueous extracts, they were used to carry out t...

Kadja Amani Brice *, Atsain-Allangba Marie Rosine, Kouassi Kouassi Stéphane, Mamyrbékova-Békro Janat Akhanovna and Békro Yves-Alain

Laboratoire de Chimie Bio-Organique et de Substances Naturelles / UFR-SFA / Université Nangui Abrogoua, 02 BP 801 Abidjan 02.

DOI: 10.13040/IJPSR.0975-8232.13(1).417-26

417-426

323

161

48.

CHARACTERIZATION AND ANALYSIS OF BIOACTIVE OF DIGERA ARVENSIS BY FTIR

The present study is focused on exploring the chemical components of the leaves, stem, root, and seeds of potential weed Digera arvensis. The plant has high nutritional value and therapeutic significance with prospective pharmacological activities. The various parts of the plants, i.e., leaves, stems, roots and seeds, were extracted using polar solvent ethanol. The preliminary phytochemical invest...

N. Pruthvi *, Saritha Surapaneni, V. B. Narayanaswamy and K. Selvakumar

Department of Pharmacognosy, R. R. College of Pharmacy, Bengaluru , Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).427-33

427-433

361

148

49.

PHARMACOGNOSTIC CHARACTERIZATION OF THE LEAVES OF STEVIA REBAUDIANA BERT

For the last few centuries, the leaves of Stevia rebaudiana have been used as an efficient substitute for sugar due to its sweetness and almost negligible Glycemic effects. The study concentrates on the pharmacognostic aspects and other anatomical characteristics of the leaves. The study is performed on the plant leaves collected from the medicinal plant garden of Birla Institute of Technology, Me...

S. Mitra * and A. Pandey

Division of Pharmacognosy and Phytochemistry, Dr. B. C. Roy College of Pharmacy & AHS Durgapur, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).434-38

434-438

402

161

50.

STABILITY INDICATING ASSAY OF TELMISARTAN IN TABLETS

An accurate, simple, precise, rapid stability-indicating assay method was developed and subsequently validated for the estimation of Telmisartan in API and Tablets. The best separation of the drug was achieved on Kromasil C18 (4.6 × 150 mm, 5 µm) with the mobile phase consisted of mixture of 0.01 M Phosphate buffer (pH: 3) and Acetonitrile in ratio of (40:60%) at flow rate of 2 ml/min, with dete...

L. K. Sahu *, S. Si and S. K. Patro

School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).439-44

439-444

445

191

51.

BETA-GLUCOGALLIN PREVENTS SCOPOLAMINE-INDUCED AMNESIA VIA CHOLINERGIC MODULATION AND ANTI-OXIDATIVE EFFECTS IN MICE

Background: Beta-glucogallin (BGG) is a tannin precursor naturally found in a variety of plants such as gooseberry, raspberry, amla, etc. BGG was reported to be a potential therapeutic agent in managing a variety of diseases. This investigation was intended to assess whether BGG alleviates amnesia induced by scopolamine in mice. We also investigated possible mechanisms associated with the choliner...

P. Rahul Pol *, J. Remeth Dias and S. Nilofar Naikwade

Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).445-57

445-457

300

174

52.

A PROSPECTIVE OBSERVATIONAL STUDY ON ADVERSE DRUG REACTION AMONG PATIENTS IN A TERTIARY CARE HOSPITAL

Adverse drug reactions (ADRs) cause considerable morbidity and mortality worldwide. The pharmacovigilance activities continuously update about the adverse reactions related to medications and provide information regarding the nature and severity of ADRs. The study aims to assess the causality assessment of ADRs among patients in a tertiary care hospital. A prospective observational study was condu...

S. Surekha and E. Bhavya *

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).458-63

458-463

626

286

53.

FORMULATION AND EVALUATION OF GASTRO RETENTIVE MUCOADHESIVE FILM OF RITONAVIR

Objective: The research work aims to formulate and evaluate the Gastro retentive mucoadhesive film of Ritonavir using polymers like HPMC K15M, Polyvinyl alcohol, and PEG 400 as a plasticizer by solvent casting method for treatment of AIDS. Method: Prepared gastro retentive mucoadhesive films were evaluated for various parameters such as in-vitro unfolding behavior of film, Folding endurance, Perce...

P. Shailaja * and G. Loknadh

AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).464-70

464-470

353

185

54.

A CROSS-SECTIONAL STUDY TO ANALYSE PRESCRIBING PATTERNS AND TECHNIQUES OF SWITCHING OVER OF ANTIPSYCHOTICS IN VARIOUS PSYCHOTIC DISORDERS

Patients with psychotic disorders often require long-term and intensive treatment. Several drug utilization studies have been carried out using WHO (World Health Organization) prescribing indicators, but these studies are deficient for psychiatry patients in India. To analyze antipsychotic prescriptions according to WHO core prescribing indicators and identify various techniques used for switching...

Amanpreet Kaur, Vijay K. Sehgal, Jasbir Singh and Rohit Garg *

Department of Psychiatry, Government Medical College and Rajindra Hospital, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).471-77

471-477

366

197

55.

SEXUAL DIMORPHISM OF FEMUR IN THE POPULATION OF ODISHA: AN ANTHROPOMETRIC OBSERVATIONAL STUDY

Introduction: Femur is the key bone among the skeletal remains to determine sex for anatomists, anthropologists, and forensic experts. In the present study, we considered most of the parameters to determine sex from the femur. Methods: We studied eighty-four undamaged, intact femora of unknown sex. The present study were carried out in S. C. B. Medical College Cuttack from December 2019 to April 2...

Kanchan Rajeev Kumar, Subhadarsini Sonali, D. N. Mishra * and C. Mohapatra

Department of Anatomy, S. C. B. Medical College Cuttack, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).478-83

478-483

349

222