Volume 13 (2022) - Issue 1, January
An extensive range of studies have shown plant extracts and their phyto-constituents efficacy, proposing them as a promising alternative for treatment or as adjuvants in human diseases such in skin, gastrointestinal, systemic and dental conditions, due to various active components presence, ease of access and reduced side effects. Indeed, depending on solvent used to obtain the extract, its active...
EUPHORBIA HIRTA LINN. – AN INVASIVE PLANT: A REVIEW OF ITS TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES
Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed with the aim to compile updated information on E. hirta including its medicinal us...
ROLE OF VITAMIN D IN CARDIOMETABOLIC DISORDERS – A REVIEW BASED ON PATHOPHYSIOLOGY AND CLINICAL EVIDENCES
Background: Cardiometabolic syndromes are the co-occurrence of metabolic abnormalities such as obesity, insulin resistance, atherogenic dyslipidemia, and hypertension. Cardiometabolic disorders includes type2 diabetes mellitus, metabolic syndrome, and cardiovascular diseases. The prevalence of cardiometabolic disorders are growing in epidemic proportions all over the world; hence cardiometabolic d...
In organic chemistry, the largest families of organic compounds belong in the heterocyclic compounds. In our daily life, the importance of heterocyclic compounds is very essential. It has a broad range of applications in medicinal chemistry. Benzotriazole is a bicyclic heterocyclic system consisting of three nitrogen atoms and a fused benzene ring, shows wide range of biological and pharmacologica...
Micro sponges are patented polymeric drug delivery systems consisting of porous microspheres. The physical appearance of microsponges is tiny spherical sponge-like with the surface with large spores. Micro sponges are typically used and nowadays used as the oral dosage form. The inert and indestructible tiny spherical particles do not pass through the skin. But, it collects in the tiny nooks and c...
Quality by Design (QbD) is an essential part of modern pharmaceutical development. QbD is a requisite for the design and development process for the pharmaceutical industry. QbD assists and encourages both the industries and FDA to inculcate a proactive, scientific and risk-based approach in the process and product development. It is based on a concept of building quality right from the start of t...
Discovery of the drug molecule which has therapeutic values is the backbone of drug development. Pharmaceuticals have an important role in the prevention and treatment of diseases in humans and animals. However, gradual change in the process of drug synthesis from drug development to bulk production is a common complication in the drug development process. This change may result in the formation o...
Currently, oral drug delivery and parenteral drug delivery are used for the treatment of various diseases. In the oral drug delivery system, due to the first-pass metabolism and acidic environment of the gastrointestinal route, the drug exposes to acids and enzymes present in the gastrointestinal tract, which may lead to degradation of the compound, which ultimately results in poor bioavailability...
Chronotherapeutic systems are meant for the treatment of most of the diseases that occurred and found till date, which are proved to be in association with the biological/circadian rhythms of our body with respect to disease symptoms and their severity. Such diseases use this treatment as it involves in-vivo drug availability with distinctive release patterns so as to match the rhythms of disease ...
Tissues can be preserved for centuries under the conditions of extremely cold temperatures along with the neurological functions of the human brain. It is possible with the process of vitrification; here the cells of the brain are cooled to the cryogenic temperature without the formation of ice. Damage caused due to this process is theoretically reversible as like before, but practically, rejuvena...
Gene targeting has been a promising drug delivery system, thereby helping to improve the impaired functioning in various disorders. "Lipoplexes" and "Polyplexes" incorporates lipids and polymers combined with bioactive molecules, drugs, or genes are one of the newly developing systems. The need to protect genes from degradation, allowing them to reach their target site and to promote an efficient ...
Characteristics like dementia, behavioural and cognitive dysfunction, and memory decline may characterize Alzheimer's disease (AD). A deterioration of short-term memory, inability to acknowledge new information, mood swings, difficulty recognizing words, forgetting names, and losing things are demonstrated by early disease. Popular emotional characteristics displayed by patients with AD are anger,...
COMPARISON OF THREE TECHNIQUES FOR THE DIAGNOSIS OF MALARIA IN RESOURCE-LIMITED SETTINGS: A MINI-REVIEW
Objective of this article is to review three techniques, routinely used rapid diagnostic tests (lateral flow immune chromatography) versus nucleic acid amplification test (NAT) versus Paper-based microfluidics for DNA diagnostics of Malaria, as diagnostic tests in detecting malarial infection among febrile illnesses, suspected of malaria. The major constraint for implementing NAT as a routine scre...
Infertility is an inability to achieve pregnancy in spite of regular, unprotected coitus in one year. Infertility affects about 15% of couples, in which the malefactor contributes to 40% worldwide. There are various risk factors, causes, and treatment modalities for male infertility, of which Selective Estrogen receptor modulators (SERMs) are one of the promising treatments available for treating ...
SARS-CoV-2 viral cause infection called COVID-19 was initially reported in China has resulted in a pandemic because it has spread in over 210 countries. This review summarized pathophysiology, clinical features, diagnosis, and COVID 19. The spread of SARS-CoV-2 viral infections is a matter of concern because of a mutant variant of virus. The COVID-19 infection is having 14 days incubation period. ...
AN INTELLIGENT DATA ANALYTICS SYSTEM FOR THERAPEUTIC OF ANGINA PECTORIS IN CARDIOVASCULAR DISEASE MANAGEMENT: A MODEL METHODOLOGY
Medical Case taking process in any field of medicine science is considered to be a significant stage for the treatment management of various diseases. Cardio Vascular diseases (CVD) are one of the life-threatening diseases across the globe, and its prognosis entirely depends on the right intuition of the clinicians; cases may account for 31% of deaths worldwide, based on a recent study. Big Data M...
The aim of this study is to evaluate metformin and insulin effects on metabolic disorders and oxydatif stress markers, in Algerian men with T2D, in order to recommend the best treatment, which can minimize diabetes complications and recommend/or not a combination between metformin and insulin. Patients and Methods: We made this study on 120 subjects men divided into four groups (30 healthy control...
CHARACTERIZATION OF BIOACTIVE METABOLITES FROM MARINE MACROALGAE COLLECTED FROM VERAVAL COAST OF GUJARAT
Seaweeds are potential sources of bioactive molecules. They are known to be rich sources of proteins, carbohydrates, lipids, vitamins, minerals, and other secondary metabolites. To evaluate the presence of these compounds in marine macroalgae collected from Veraval coast of Gujarat, present studies was carried out. The methanol extract of six macroalgae species (Ulva lactuca, Ulva faciata, Acantho...
Topical formulations may contribute to the reduction of oxidative stress in the skin. Banana peel is a fruit waste with antioxidant activity that is not yet included in a topical formulation. The aim of this study was to evaluate the antioxidant and anti-aging activity of a cream formulation containing a lyophilized extract of banana peel. The banana peel was extracted with ethanol, and a cream fo...
A new series of Schiff's base compounds were synthesized by condensation of 1-(4-amino-4 phenyl) 3-phenyl triazene-1-ol) and substituted aldehyde and gave high yields of target compounds. Antimicrobial activity of compounds has been tested against bacterial and fungal species, namely gram-positive bacteria as S. aureus and S. pyogenes, gram-negative bacteria as E. coli and P. aeruginosa, and funga...
The antibacterial property of three Himalayan Oaks species (Quercus floribunda, Q. leucotrichophora and Q. semecarpifolia) in different solvents against eight gram-positive and gram-negative pathogenic bacteria employing disc diffusion method has been investigated. All the test microorganisms were inhibited significantly by Oaks species at 1000 μg/ml. The MIC and MBC values of each extract (where...
AMELIORATION OF 131I INDUCED SALIVARY GLAND DAMAGE BY OCIMUM SANCTUM AND AMIFOSTINE PRE SUPPLEMENTATION IN RABBITS
Oral administration of 131I to the patients of differentiated thyroid cancer is routinely used to ablate remnant thyroid tissue or metastasis. In 30% of the patients, permanent salivary gland damage due to therapeutic 131I exposure results in xerostomia, affecting their quality of life. Amifostine is the only standard FDA-approved radio protect ant available for damage control, albeit associated w...
A RETROSPECTIVE AUDIT OF DRUG PRESCRIBING PATTERNS AMONG THE PATIENTS VISITED THE DENTAL CLINIC OF A PRIVATE MEDICAL UNIVERSITY IN KEDAH, MALAYSIA
Introduction: Irrational use of drugs is widespread in present-day medical practice. Hence, the present study aimed to analyze the drug prescribing pattern among the patients who visited the Faculty of Dentistry dental clinic, AIMST University. Methods: A retrospective, cross-sectional study was conducted to analyze the drug prescribing pattern of dentists of AIMST University, Kedah, Malaysia. A t...
Positron emission tomography (PET) imaging has been broadly used in the study of brain damage for a long time. However, PET has been mostly used for the assessment and detection of neural activity after brain damage. Tau proteins play a significant role in a variety of degenerative neurological conditions. Post-mortem neuropathology studies of victims of repeated and severe head trauma have define...
Many species of the genus Selaginella P. Bauev. (family: Selaginellaceae) are used as traditional medicine. In India, S. involvens (Sw.) Spring and S. bryopteris (L) Bak are used for medical purposes. In some works, these two species have been treated as resurrection plants or ‘Sanjeevani’. These plants have considerable morphological similarity which can create confusion regarding the exact p...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF GLIPIZIDE AND MOMORDICININ IN RAT PLASMA
Momordicinin (MMR) is a major triterpenoid compound from Momordica charantia Linn fruit having antidiabetic potential, whereas glipizide (GPZ) is a well-known molecule in treatment of diabetes mellitus. The primary objective of the study is to develop and validate a simultaneous RP-HPLC method for upcoming pharmacokinetic studies to analyze herb-drug interactions. The study uses the protein precip...
EVALUATION OF HYDROCHLOROTHIAZIDE AND METHYLDOPA SIMULTANEOUSLY BY APPLYING CHEMOMETRIC SPECTROPHOTOMETRIC METHOD
In the present work, simultaneous estimation of Hydrochlorothiazide and Methyldopa was carried out by applying chemometric assisted UV spectro-photometric methods. The Two chemometric methods, classical least square (CLS) and inverse least square (ILS) were applied for estimation of Hydrochlorothiazide and Methyldopa simultaneously in tablets without any prior separation, and no graphical treatmen...
Dental caries is considered one of the major oral health issues throughout the world. Synthetic drugs and antibiotics have major side effects and can develop resistance. Ficus benghalensis F. benghalensis is a plant with enormous established pharmaceutical properties. The present study was designed to evaluate the antimicrobial activity of water, and ethanolic extracts of F. Benghalensis leaves ag...
Fostemsavir was quantified using a simple and reliable HPLC technique developed and validated. PhenomenexC18 column was used to achieve chromatographic segregation (150 x 4.6 mm, 5m). The mobile phase was a 55:45 mixture of 0.01N disodium orthophosphate and acetonitrile pumped through the column at 1.0ml/min. The temperature was maintained at 30 °C and the buffer used was 0.01N sodium dihydrogen ...
DEVELOPMENT OF HERBAL NANO EXTERNAL FORMULATION AS OINTMENT WITH URENA LOBATA EXTRACT AND VALIDATION OF ITS WOUND HEALING ACTIVITY IN EXPERIMENTALLY INDUCED OPEN WOUNDS IN SWISS ALBINO RATS
Urena lobata is used by traditional practitioners for treating external wounds. A preclinical study was conducted to evaluate the efficacy of the ointment formulations containing ethanolic extract of Urena lobata (EO) (5%) and nanosized extract (NO) of U. lobata (5%) for their wound healing activity by assessing wound contraction, tensile strength, superoxide dismutase, catalase, reduced glutathio...
A model of ascending Urinary tract infection (UTI) in rats was developed to study the significance of antibacterial activity of Sphaeranthus indicus L. and compared with standard antibiotic ofloxacin as a positive control. This plant used in folk medicine as a remedy for urinary tract infections is belong to Asteraceae family. Outbred female wistar rats were used throughout the study and Escherich...
QUALITATIVE AND QUANTITATIVE ANALYSIS OF PHYTOCHEMICALS AND EVALUATION OF IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF THREE SELECTED AYURVEDIC MEDICINAL PLANTS USED IN RHEUMATOID ARTHRITIS MEDICATIONS
This research was focused on the qualitative and quantitative analysis of phytochemicals and evaluation of in-vitro antioxidant and anti-inflammatory activities of three commonly used plant parts in rheumatoid arthritis medications in Ayurveda, namely, the root of Boehmeria nivea, the barks of Gmelina arborea and Oroxylum indicum, using standard methods. Qualitative analysis of each methanol extra...
Leishmaniasis is a neglected tropical infectious disease affecting poor people, especially in the developing countries of the world. It is a systemic disease caused by a protozoan parasite leishmania donovani and is fatal if left untreated. The aim of the present study is to develop and evaluate the in-vitro antileishmanial activity of the combination of amphotericin B and mitefosinenano vesicles ...
INFLUENCE OF LORNOXICAM ON HYPOGLYCEMIC POTENTIAL OF SOME ORAL HYPOGLYCEMIC AGENTS IN NORMAL AND DIABETIC RATS
Objective: The objective was to study drug-drug interaction between Lornoxicam and oral hypoglycemic agents in normal and Streptozotocin-induced diabetes in rats. Material and Method: The protocol was blueprinted in two phases. In the first segment, the influence of Glibenclamide (0.7mg/kg/p.o.) and Glipizide (1.05mg/kg/p.o.) once daily on blood glucose levels in normoglycemic rats were studied ...
RADIOLOGICAL AND GENE-EXPERT PATTERN: IN RELATION WITH TREATMENT OUTCOME OF SENSITIVE AND RESISTANT TUBERCULOSIS
Even if there are so many diagnostic tests available for the detection of tuberculosis, still the diagnosis of TB is a challenging problem in this decade due to differences or non-specificity in symptoms, radiological signs, false negatives, and positives. Chest X-ray can identify the location, area, and morphology of lesions; hence analyzed the pattern and relation of chest X-ray and Gene expert ...
HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF ABROMA AUGUSTA AGAINST NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN SD RATS
To study the hepatoprotective activity of ethanolic leaves extracts of Abroma augusta against non-alcoholic fatty liver disease to validate ethnobotanical claim regarding the plant used in the above mentioned disease. Materials and Methods: The hepatoprotective potential of Abroma augusta leaves extract (AALE) (250 and 500 mg/kg/ body weight) was studied on Methionine and Choline deficient diet (M...
TARGET-BASED APPROACH FOR IN SILICO STUDIES, DESIGN, SYNTHESIS, AND ANTIULCEROGENIC POTENTIAL OF NOVEL 1,4 DIHYDROPYRIDINE DERIVATIVES
In-silico studies play a very crucial role in medicinal chemistry and synthesis of the lead compound. As we know that 1,4-Dihydropyridine is a versatile molecule, and previous studies have shown that it possesses therapeutic activity in different diseases, such as anticancer, anticonvulsant, anticoagulant, anti-Alzheimer, antitubercular antiulcer. As described by the researchers, 1,4 Dihydropyridi...
A STUDY ON THE ADVERSE DRUG REACTIONS OF HIV-TB CO-INFECTED PATIENTS IN A TERTIARY CARE HOSPITAL OF NORTH EAST INDIA – A PROSPECTIVE COHORT STUDY
The reporting of adverse drug reactions after taking any medicines is very much essential to establish a safe patient profile for drugs. The co-infection of HIV and TB has been a major concern for the healthcare system, and the various drugs interaction from taking ART and ATT should be highlighted to avoid unwanted reactions. The present study was conducted in a hospital set up for a period of on...
AN EXPERIMENTAL STUDY TO EVALUATE THE EFFECT OF TRANDOLAPRIL AND NIMODIPINE IN ANXIETY, DEPRESSION AND MOTOR COORDINATION USING BEHAVIORAL MODELS IN SWISS ALBINO MICE
The present study aimed to assess the role of angiotensin-converting enzyme inhibitor (trandolapril) and calcium channel blocker (nimodipine) in anxiety, depression, and motor coordination using behavioral models in mice. This was an experimental study involving 72 swiss albino mice divided into 12 groups. Groups 1 to 4 were used to evaluate the anxiolytic effect using Y maze after 5 days of t...
APPLICATION OF THE INFORMATION TECHNOLOGIES IN EARLY PREDICTING THE SEVERITY OF ATOPIC DERMATITIS IN CHILDREN
The application of mathematically based prognostic software is a rational and promising approach to determining disease prognoses. In our research, we identified indicators as prognostic criteria for the development of atopic dermatitis (AD). Our research involved 260 healthy children and 268 newborns with AD. To select the risk factors for predicting the formation of AD, initially, variation and ...
HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY OF MORINGA OLEIFERA LEAF POWDER IN ALLOXAN-INDUCED DIABETIC RABBITS
The present study was carried out to investigate the hypoglycemic and hypolipidemic effect of Moringa oleifera leaf powder (MO) in alloxan-induced diabetic rabbits by administering oral doses (100, 200, and 400 mg/kg body weight). Diabetes was induced intravenously into rabbits with a single dose of alloxan (150 mg/kg). Diabetic rabbits were treated with MO (100, 200, and 400 mg/kg) and Glibenclam...
Pioglitazone is an oral anti-diabetic agent used in treating class – II diabetes mellitus. T1/2of pioglitazone was 3-6 hrs and is eliminated rapidly. Hence sustained release is needed to prolong its duration of action and to increase its oral bioavailability. The study's main aim was formulation and evaluation of an in-situ gel system of pioglitazone to increase its bioavailability as a convenie...
CLINICAL DIAGNOSIS AND SAFETY OF VILDAGLIPTIN VERSUS GLIMEPIRIDE WITH METFORMIN OVER PATIENTS OF TYPE-2 DIABETES MELLITUS
The aim of the study to compare the efficacy of vildagliptin (50 mg) and glimepiride (2 mg) metformin (500 mg) for type-2 diabetes mellitus. Vildagliptin and glimepiride are found to be regulated the blood plasma glucose by stimulating beta cell in the pancreas. The treatment course duration of 34 weeks comparative observational study was conducted over 160 patients with type-2 diabetes mellitus w...
IN-SILICO DESIGN AND COMPUTATIONAL STUDY OF NOVEL QUINAZOLIN-4-ONE DERIVATIVES AS POTENTIAL AFFINITY WITH EGFR FOR ANTICANCER ACTIVITY
Molecular object precise healing designed for the malignancy be unrelated as of the predictable therapy, as well as radio healing in conditions of selectivity and specificity target to the malignant tyrosine kinase, is well-thought-out additional shows potential molecular intention for invention and expansion of the new cytotoxic drug molecules. Epidermal growth factor receptor is overexpression i...
PROTECTIVE ACTIVITY OF THE METHANOLIC EXTRACT AND ITS SOLVENT FRACTIONS OF THE FRUITS OF SOLANUM NIGRUM (MAKO) ON GENTAMICIN-INDUCED NEPHROTOXICITY IN ALBINO RATS
Objective: Mako (Solanum nigrum L.), Black Nightshade in English, belongs to the family Solanaceae is an edible plant. The whole plant is used as a green source of vegetables and berries as a fruit. It is a good source of antioxidant and has potent anti-inflammatory, diuretic, lithotriptic, wound healing properties. Unani scholars have advocated the berries to treat many renal ailments, including ...
Hugonia mystax is a woody evergreen plant that grows in the dry forest areas of India and Sri Lanka. Often found in the forests of Kerala and Tamil Nadu in southern India. It is locally known as modirakanni (tamil) and kamsamaraha and tribals from Tamil Nadu, India, have used it in primary health care. The plant parts are used ethnobotanically to treat rheumatism, skin diseases and inflammations, ...
PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF EXTRACTS OF AZADIRACHTA INDICA A. JUSS (MELIACEAE) (CÔTE D’IVOIRE)
The purposes assigned to this work are the phytochemical screening of certain phytoconstituents, the estimation of the antioxidant and antibacterial activities of extracts of Azadirachta indica A. Juss. The selective extracts obtained from the aqueous decocts were used to establish the chromatographic profile of the various extracts. As for the crude aqueous extracts, they were used to carry out t...
The present study is focused on exploring the chemical components of the leaves, stem, root, and seeds of potential weed Digera arvensis. The plant has high nutritional value and therapeutic significance with prospective pharmacological activities. The various parts of the plants, i.e., leaves, stems, roots and seeds, were extracted using polar solvent ethanol. The preliminary phytochemical invest...
For the last few centuries, the leaves of Stevia rebaudiana have been used as an efficient substitute for sugar due to its sweetness and almost negligible Glycemic effects. The study concentrates on the pharmacognostic aspects and other anatomical characteristics of the leaves. The study is performed on the plant leaves collected from the medicinal plant garden of Birla Institute of Technology, Me...
An accurate, simple, precise, rapid stability-indicating assay method was developed and subsequently validated for the estimation of Telmisartan in API and Tablets. The best separation of the drug was achieved on Kromasil C18 (4.6 × 150 mm, 5 µm) with the mobile phase consisted of mixture of 0.01 M Phosphate buffer (pH: 3) and Acetonitrile in ratio of (40:60%) at flow rate of 2 ml/min, with dete...
BETA-GLUCOGALLIN PREVENTS SCOPOLAMINE-INDUCED AMNESIA VIA CHOLINERGIC MODULATION AND ANTI-OXIDATIVE EFFECTS IN MICE
Background: Beta-glucogallin (BGG) is a tannin precursor naturally found in a variety of plants such as gooseberry, raspberry, amla, etc. BGG was reported to be a potential therapeutic agent in managing a variety of diseases. This investigation was intended to assess whether BGG alleviates amnesia induced by scopolamine in mice. We also investigated possible mechanisms associated with the choliner...
A PROSPECTIVE OBSERVATIONAL STUDY ON ADVERSE DRUG REACTION AMONG PATIENTS IN A TERTIARY CARE HOSPITAL
Adverse drug reactions (ADRs) cause considerable morbidity and mortality worldwide. The pharmacovigilance activities continuously update about the adverse reactions related to medications and provide information regarding the nature and severity of ADRs. The study aims to assess the causality assessment of ADRs among patients in a tertiary care hospital. A prospective observational study was condu...
Objective: The research work aims to formulate and evaluate the Gastro retentive mucoadhesive film of Ritonavir using polymers like HPMC K15M, Polyvinyl alcohol, and PEG 400 as a plasticizer by solvent casting method for treatment of AIDS. Method: Prepared gastro retentive mucoadhesive films were evaluated for various parameters such as in-vitro unfolding behavior of film, Folding endurance, Perce...
A CROSS-SECTIONAL STUDY TO ANALYSE PRESCRIBING PATTERNS AND TECHNIQUES OF SWITCHING OVER OF ANTIPSYCHOTICS IN VARIOUS PSYCHOTIC DISORDERS
Patients with psychotic disorders often require long-term and intensive treatment. Several drug utilization studies have been carried out using WHO (World Health Organization) prescribing indicators, but these studies are deficient for psychiatry patients in India. To analyze antipsychotic prescriptions according to WHO core prescribing indicators and identify various techniques used for switching...
Introduction: Femur is the key bone among the skeletal remains to determine sex for anatomists, anthropologists, and forensic experts. In the present study, we considered most of the parameters to determine sex from the femur. Methods: We studied eighty-four undamaged, intact femora of unknown sex. The present study were carried out in S. C. B. Medical College Cuttack from December 2019 to April 2...