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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 7 (2016) - Issue 10, October

Review Articles

 
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1.

PATHOGENESIS AND NEURO-PROTECTIVE AGENTS OF STROKE

Stroke remains world’s second leading cause of mortality; and globally most frequent cause of long-lasting disabilities. The ischaemic pathophysiologic cascade leading to neuronal damage consists of peri-infarct depolarization, excitotoxicity, inflammation, oxidative stress, and apoptosis. Despite plethora of experimental evidences and advancement into the development of treatments, clinical tre...

Mubarak Muhammad *, Abbas B. El-ta’alu and Muhammad I. Mabrouk

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Science, Bayero University Kano, Nigeria

DOI: 10.13040/IJPSR.0975-8232.7(10).3907-16

3907-16

2757

904

2.

CANAVALIA VIROSA ROXB.: A REVIEW

Man has been dependent on plants for the treatment and cure of different diseases since time immemorial. Plants have served not only as a source of food and shelter but also as a very important source of different “portions” used for the treatment and cure of diseases. These portions are herbal or plant based mixtures made by traditional healers; who are individuals having a knowledge of medic...

Angela E. Peter *, D. Aruna, P. Sudhakara Rao, B. V. Sandeep and B. Ganga Rao

Department of Biotechnology , Andhra University, Visakhapatnam, AP, India

DOI: 10.13040/IJPSR.0975-8232.7(10).3917-23

3917-23

3388

918

3.

FLAVONOIDS: THERAPEUTIC POTENTIAL OF NATURAL PHARMACOLOGICAL AGENTS

Flavonoids are the natural compound widely distributed in plant kingdom, it is responsible for the various colors exhibited by bark, leaves, flowers, fruits and seeds of plants. They are the secondary metabolites of plant with significant antioxidant properties. Flavonoids have antioxidant, sedative, antidepressant, anticonvulsant, anti-proliferative, anti-inflammatory, anti-microbial, anticancer,...

K.S. Sridevi Sangeetha, S. Umamaheswari *, C. Uma Maheswara Reddy and S. Narayana Kalkura

Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University, porur, Chennai, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.7(10).3924-30

3924-30

5115

1335

Research Articles

 
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4.

INVESTIGATING THE EFFECT OF MOLECULAR WEIGHT OF POLYVINYLPYRROLIDONE AND HYDROXYPROPYL METHYL CELLULOSE AS POTENTIAL ANTIPRECIPITANTS ON SUPERSATURATED DRUG SOLUTIONS AND FORMULATIONS USING WEAKLY ACIDIC DRUG: INDOMETHACIN

Most of the drug discovered in past decade belongs to biopharmaceutical classification system (BCS) class II. The solubility of these drugs is the limiting factor for oral bioavailability. The drug can be present in solution in a supersaturated state; however, it has a tendency to crystallize out. In this paper, we aim to study the effect of molecular weight of Polyvinylpyrrolidone (PVP) (PVP K12,...

Smruti P. Chaudhari and Rutesh H. Dave *

Director, Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York, USA

DOI: 10.13040/IJPSR.0975-8232.7(10).3931-48

3931-48

3663

948

5.

IN VIVO ANTIHYPERLIPIDEMIC, ANTIOXIDATIVE EFFECTS OF COCCINIA GRANDIS (L.) VOIGT (CUCURBITACEAE) LEAF EXTRACT: AN APPROACH TO SCRUTINIZE THE THERAPEUTIC BENEFITS OF TRADITIONAL SRI LANKAN MEDICINES AGAINST DIABETIC COMPLICATIONS

Coccinia grandis (Linn.) Voigt (Cucurbitaceae) has been widely used for the management of diabetes mellitus in Sri Lankan traditional medicine. The aim of the present study was to investigate antihyperlipidemic, antioxidative effects of the leaf extract of C. grandis in sterptozotocin induced diabetic rats and to standardize the leaf extract of C. grandis by standard analytical methods. The result...

A. P. Attanayake*, K.A.P.W. Jayatilaka , L.K.B. Mudduwa and C. Pathirana

Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Karapitiya, Sri Lanka

DOI: 10.13040/IJPSR.0975-8232.7(10).3949-58

3949-58

2165

939

6.

OPTIMIZATION OF VARIOUS PROCESS PARAMETERS FOR FORMULATION OF MODEL ANTI-HYPERLIPIDEMIC DRUG BY USING DRY GRANULATION METHOD

The Tablet manufacturing  process is a complex process, influenced by several process variables The aim of this study was to optimize blending; roller compaction and tablets compression processes using design space approach for a model Anti- Hyperlipidemic drug Fluvastatin. During each processes there are several factors which may affect product quality. So the main objective of present work was ...

Himankar Baishya*, Athappan Chidambaram and Zhao Haitho

Senior Director, R & D, Beijing Sciecure Pharmaceuticals Co., Ltd., Beijing, China

DOI: 10.13040/IJPSR.0975-8232.7(10).3959-70

3959-70

7733

1054

7.

SELF-ASSEMBLED BIODEGRADABLE POLYMERIC NANOPARTICLES WITH IMPROVED SOLUBILITY OF CARVEDILOL: PREPARATION, CHARACTERISATION AND IN VITRO RELEASE KINETICS

Nanoparticles (NPs) have been extensively studied during the past few decades due to their well-recognised applicability. Thus, the present study was aimed to fabricate Carvedilol (CVD) a β-adrenoceptor antagonist, as NPs aiming towards the optimal physicochemical characteristics and improved solubility. The prepared NPs demonstrated a linear increase in the mean particle size from253 ± 19 to 59...

S. Khan , W. Ali, N. Ur Rahman, S. Md. Mukarram Shah, J. Khan, S. Md. Hassan Shah, Z. Hussain *

Department of Pharmaceutics , Faculty of Pharmacy, Universiti Teknologi MARA, PuncakAlam Campus, Selangor, Malaysia

DOI: 10.13040/IJPSR.0975-8232.7(10).3971-85

3971-85

2402

638

8.

THE EFFECT OF UGT1A6 POLYMORPHISM AT TWO LOCI ON THE CLINICAL RESPONSE TO VALPROIC ACID IN EPILEPTIC CHILDREN

Background and Aim: Valproic acid (VPA) is a widely used antiepileptic drug. The main pathway of its elimination is through conjugation by UDP-glucuronosyltransferases with several polymorphic forms. In this study, we aimed to examine the effect of polymorphism in UGT1A6 enzyme-coding gene at two loci, namely, 541A>G and 552A>C on clinical outcome in Egyptian children with idiopathic epileps...

E.A Algharably *, M. El Hamamsy, S. M. Hassanein, N.A. Mohamed, M.Z. Mahran, M.A. El-Sawy and O.A. Badary

Department of Clinical Pharmacy, Faculty of Medicine, Ain Shams University, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(10).3986-94

3986-94

2419

625

9.

SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF THIAMINE HYDROCHLORIDE IN PURE FORM, PHARMACEUTICAL AND BIOLOGICAL FLUIDS

Thiamine hydrochloride, also known as Vitamin B1, is a water-soluble vitamin which is important biologically and pharmaceutically. A new simple and sensitive spectrophotometric method has been developed for the determination of Thiamine Hydrochloride (Vitamin B1) in pure form and biological fluids. The method is based on the diazotization reaction of Thiamine Hydrochloride with Procaine HCl which ...

Hind S. Al-Ward* and Saba Zuhair Hussein*

Department of Chemistry-College of Science-University of Baghdad, Baghdad, Iraq

DOI: 10.13040/IJPSR.0975-8232.7(10).3995-03

3995-03

6219

917

10.

THE EFFECT OF PURIFIED NIGELLA SATIVA LECTIN AGAINST TUMOR DEVELOPMENT IN FEMALE ALBINO MICE AND GENETIC POLYMORPHISM IN PUMA GENE

The purpose of this study examine whether the polymorphism in p53 upregulated modulator of apoptosis (PUMA) gene consequential treated with purified Nigella sativa lectin in tumor induced mice. Nigella sativa (N. sativa) is a widely used medicinal plant throughout the world. Possess a seed lectin that was purified by combination of ammonium sulfate precipitation and affinity chromatography on a Se...

Wael S. Abdel-Mageed *, Marwa M. Marey and Khalil El-Halfawy

Lecturer of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, Sadat University, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(10).4004-13

4004-13

2111

614

11.

TOXICOLOGICAL EVALUATION OF FIVE SRI LANKAN MEDICINAL PLANTS: A BIOCHEMICAL, HAEMATOLOGICAL AND HISTOPATHOLOGICAL ASSESSMENT

Asteracantha longifolia, Asparagus falcatus, Vetiveria zizanioides, Coriandrum sativum and Epaltes divaricate have proven hepatoprotective and antioxidative effects against carbon tetrachloride and paracetamol induced hepatotoxicity in mice and are widely used in Sri Lanka for the treatment of liver disorders. However, toxicological information regarding their safety after exposure to experimental...

R. P. Hewawasam *, K A P W Jayatilaka, L. K. B. Mudduwa and C. Pathirana

Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Sri Lanka.

DOI: 10.13040/IJPSR.0975-8232.7(10).4014-21

4014-21

2502

595

12.

STUDY OF THE INVOLVEMENT OF ADIPONECTIN AND HOMA-IR IN TUNISIAN SUBJECTS WITH METABOLIC SYNDROME

Metabolic syndrome (MS) is a multi-factorial disorder with insulin resistance as a major characteristic. Adiponectin, an adipocyte derived cytokine, can regulate glucose levels and lipid homeostasis by its insulin sensitizer properties. Low circulating levels of serum adiponectin has been reported as a risk factor for the development of MS. The aim of this case control study was to investigate the...

Sondes Sahli *, Abir Jaballah, Latifa Khlifi, Henda Chahed, Salima Ferchichi and Abedelhedi Miled

Biochemistry Laboratory CHU Farhat HACHED, Sousse, Tunisia

DOI: 10.13040/IJPSR.0975-8232.7(10).4022-27

4022-27

1600

539

13.

ASSESSMENT OF ANTIHYPERTENSIVE DRUGS UTILIZATION PATTERN IN BUTAJIRA ZONAL HOSPITAL, BUTAJIRA TOWN, SOUTH ETHIOPIA

Background: Many factors contribute for prevalence of high blood pressure including poor treatment compliance, lack of access to health care and lack of physician adherence to therapeutics. In Ethiopia, routine health care report is incomplete and erratic and 90% individuals diagnosed with hypertension do not properly adhere to treatment. The present study was carried out to assess the antihyperte...

Diltata Busser, Raghavendra Yarlagadda *, Seid Mussa Ahmed

Jimma University, College of Health Sciences, Department of Pharmacy, Jimma, Ethiopia

DOI: 10.13040/IJPSR.0975-8232.7(10).4028-34

4028-34

2347

630

14.

EVALUATION OF SOLID-STATE FORMS OF CURCUMINOIDS

Curcuminoids are dietary phytochemicals obtained from dried rhizomes of turmeric plant (Curcuma longa). Curcuminoids are mixture of curcumin, demethoxy curcumin and bisdemethoxy curcumin in which curcumin is a major constituent. Several polymorphic forms of curcumin were reported. The present study relates to the preparation of different solid forms of curcuminoids and to study the influence of ot...

B. Poornima*, K.V.S.R.G. Prasad and K. Bharathi

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, AP, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4035-44

4035-44

2376

530

15.

IN VITRO EVALUATION OF ANTIOXIDANT ACTIVITIES AND CHEMOPREVENTIVE POTENTIAL OF DILLENIA INDICA LINN FRUIT ON DMBA INDUCED SKIN PAPILLOMAGENESIS IN MICE

Dillenia indica linn fruit, commonly known as elephant apple has indigenous use in various culinary dishes of Assam and it has a history of being used as traditional medicine. The present study was undertaken to evaluate its antioxidant and chemopreventive properties. Ethanolic extract of Dillenia indica fruit was used as experimental sample. Antioxidant activity was studied in vitro, at concentra...

B. Borah and R. Bharali*

Department of Biotechnology, Gauhati University, Gopinath Bordoloi Nagar, Guwahati, Assam, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4045-54

4045-54

2090

679

16.

DESIGN OF CORE COMPRESSED TABLETS OF AZITHROMYCIN AND BROMHEXINE HYDROCHLORIDE AS DUAL RELEASE SYSTEM

Bromhexine hydrochloride, mucolytic agent used in the treatment of respiratory disorders. Azithromycin is use in wide variety of bacterial infections. The aim of this present work is to formulate dual drug delivery system containing azithromycin as immediate release and bromhexine hydrochloride as sustained release action. The sustained release part as core tablet of bromhexine prepared because of...

B. P. Patel * and D. M. Patel

School of Pharmacy, RK University, Rajkot, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4055-63

4055-63

2662

578

17.

EFFECT OF GLY 16 ARG SINGLE NUCLEOTIDE POLYMORPHISM ON AGONIST BINDING TO BETA 2 ADRENERGIC RECEPTOR – A STRUCTURAL PHARMACOGENOMIC APPROACH

Asthma is obAdd Newstructive disease characterized by bronchoconstriction and inflammation for which beta 2 (β2) agonists that act through the β2 adrenoceptor are the first line agents of choice. Glycine16Arginine (Gly16Arg) is a common single nucleotide polymorphism (SNP) of β2 adrenoceptor whose effects on treatment response remain inconclusive. Hence the study aims to understand and determin...

Samuel Gideon George P. * and K. Dhivya

Department of Pharmacy Practice and Pharm D, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4064-73

4064-73

1734

512

18.

PHYTOCHEMICAL & IN VITRO ANTIUROLITHIATIC STUDIES ON THE LEAF EXTRACTS OF BAUHINIA VARIEGATA LINN.

The aim of the present study is to carry out fluorescence analysis, phytochemical extraction, preliminary phytochemical screening, estimation of total flavonoids, tannins, alkaloids, steroids saponins and in vitro antiurolithiatic studies on the leaf aqueous and ethanolic extracts of Bauhinia variegata. The results of fluorescence analysis indicate that the powder on treatment with 50% H2SO4 shows...

V. Mamillapalli *, P. L. Khantamneni, Z. Mohammad, A. Mathangi, N. Nandigam, S. M. Namburi and Vani Katta

Department of Pharmacognosy and Phyto Chemistry, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Viayawada, Krishna District, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(10).4074-84

4074-84

2589

871

19.

COMPARATIVE MODELING OF INACTIVE UBIQUITIN THIOESTERASE FAM105A AND MOLECULAR DOCKING STUDIES OF SYNTHESIZED BENZIMIDAZOLE DERIVATIVES

In this study, homology modeling and molecular docking studies were performed to explore structural features and binding mechanism of synthesized benzimidazole derivatives as ubiquitin inhibitors. A homology modeling procedure was employed to construct a 3D model of ubiquitin protein by using MODELLER9.15. For this procedure, the X-ray crystal structure of Gumby / fam105b in Complex with linear Di...

M. Neelamma * and Kiran Kumar Chitluri

University College of Science, Saifabad, Osmania University, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4085-90

4085-90

1425

531

20.

SOLUBILITY ENHANCEMENT AND DEVELOPMENT OF DISPERSIBLE TABLET OF CANDESARTAN CILEXITIL

Candesartan Cilexitil is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan cilexitil is a BCS class II drug having low solubility and high permeability. Candesartan Cilexitil is a prodrug which is rapidly converted to the active drug, Candesartan, by ester hydrolysis during absorption from the gastrointestinal tract. The bioavailability of Candesartan...

A. V. Shrirao and S. Bhilegaonkar *

Department of Pharmaceutics, PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.7(10).4091-96

4091-96

1617

476

21.

DESIGN AND CHARACTERIZATION OF SOLID DISPERSED FEXOFENADINE HYDROCHLORIDE BUCCAL FILM BY CENTRAL COMPOSITE DESIGN

Fexofenadine Hydrochloride (FHCl) is a second generation antihistaminic drug which is used in the treatment of allergic rhinitis and urticaria. It is a BCS class II drug and has high first pass metabolism leading to low oral bioavailability. Drug-inclusion complex with 2HPβCD was prepared by kneading method and characterized for solubility study, FTIR study and in vitro dissolution study. Nine di...

Utakarsh U. Goankar, U. B. Bolmal* and A. P. Gadad

Department of Pharmaceutics, KLE’s College of Pharmacy, Belagavi, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4097-09

4097-09

1985

1467

22.

COMPARATIVE EVALUATION OF ANXIOLYTIC EFFECTS OF VARIOUS EXTRACTS OF OATS (AVENA SATIVA), RICE BRAN (ORYZA SATIVA) AND SPINACH (SPINACIA OLERACEA) IN EXPERIMENTAL ANIMALS

Aim of the present study was to compare antianxiety activity of various extracts of Oats (OA), Rice Bran (RB) and Spinach (SP) which are rich in phenolics mainly flavonoids and possesses excellent antioxidant property. Flavonoids are reported to have effect on central nervous system, mainly in anxiety disorders. The activity of various extracts (petroleum ether and hydroalcoholic) of all the three...

Divneet Kaur, Anjoo Kamboj and Richa Shri *

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4110-16

4110-16

1913

498

23.

GREEN SYNTHESIS AND ANTIMICROBIAL ACTIVITY STUDIES OF CURCUMINANILINE FUNCTIONALIZED ZINC OXIDE NANOPARTICLES AND COMPARATIVE STUDIES WITH ITS NON-FUNCTIONALIZED FORM

Biofunctionalization of nanoparticles is an advancement of current nanotechnology and biotechnology fields. Developing biocompatible progressive functional materials possess antimicrobial properties could be hopeful for environmentally benevolent applications. Biofunctionalization of nanomaterials is one such topic to produce the non-toxic and more efficient antimicrobial agents. The present study...

M. Jayandran and Muhamed Haneefa M. *

Department of Chemistry, AMET University, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4117-24

4117-24

2438

624

24.

NATURAL ACID CATALYSED SYNTHESIS OF SCHIFF’S BASES FROM 1-(1-PHENYL-ETHYLIDENE) SEMICARBAZIDE

The natural acid like lemon juice provides mild acidic state which used to catalyzed reaction of primary amine and aldehyde in green solvent like ethanol at room temperature reflux for 1.5 hour gives Schiff bases in good yield. Schiff bases have attracted considerable attention of us due to their significant biological activities 1 like anticancer, antitumor, anti inflammatory agents 4, insecticid...

P. S. Jadhao * and A. B. Patil

Department of chemistry, Phulsing Naik College, Pusad, District Yavatmal, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4125-29

4125-29

2756

891

25.

IN-VITRO ANTIMYCOBACTERIAL ACTIVITY OF SELECTED INDIAN MEDICINAL PLANTS TO RESISTANT STRAINS OF MYCOBACTERIUM TUBERCULOSIS

Tuberculosis (TB) remains a highly significant infection of microbial origin causing death of human in developing countries. The anti-tubercular drugs are less effective because of the emergence of multi-drug resistant strains and ineffective to extensively drug resistant strains of Mycobacterium tuberculosis. Plants are being an alternative source of anti-microbial compounds; the aim of this stud...

S. Chidambaram * and R. Swaminathan

Valliammal College for Women, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4130-33

4130-33

2018

683

26.

COMPARATIVE EFFICACY OF 1% ALENDRONATE GEL AND TETRACYCLINE FIBERS AS AN ADJUNCT TO SCALING AND ROOT PLANING: A RANDOMIZED CONTROL CLINICAL TRIAL

The objective of this study was to compare efficacy of 1% Alendronate gel and Tetracycline fibers as an adjunct to scaling and root planning (SRP). A total of 30 patients with diagnosis of chronic periodontitis (60 localized periodontitis sites) in an age group of 20-55 years were selected. None of these patients had received any non-surgical or surgical periodontal therapy and had periodontal poc...

Anjali Goel *, Sachit Anand Arora and Shivjot Chhina

Department of Periodontics, I.T.S Dental College Hospital and Research Centre, Greater Noida, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4134-39

4134-39

1960

422

27.

FORMULATION OF NATURAL MOSQUITO PAPER COIL AND EVALUATION OF MOSQUITOCIDAL ACTIVITY

The main aim of the present study is to formulate low cost natural mosquito paper coil and to evaluate the mosquitocidal activity of Annona squamosa leaf extracts. Annona squamosa Linn. is the plant belonging to the family of Annonaceae commonly known as custard apple. Several bioactive compounds have been isolated from the Annona squamosa leaf extracts reported to possess anti-diabetic activity, ...

K. Rajya Lakshmi*, M. Mounika and P. Srinivasa Babu

Vignan Pharmacy College, Vadlamudi, Guntur (dt), A.P., India

DOI: 10.13040/IJPSR.0975-8232.7(10).4140-44

4140-44

2303

517

28.

A NOVEL REVERSE PHASE LIQUID CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF ATORVASTATIN, EZETIMIBE AND FENOFIBRATE IN BULK AND TABLET DOSAGE FORM

A novel reverse phase liquid chromatographic method has been developed for the simultaneous estimation of   Atorvastatin Calcium, Ezetimibe and Fenofibrate in bulk and Pharmaceutical formulations by using reverse phase Agilent 100-5 C18 column [250mm x 4.6mm]. The mobile phase (Methanol: water) in the ratio of 70:30% v/v was pumped at a flow rate of 1ml/min and the column effluents were monitore...

B. Praveen Kumar *, S. Vidyadhara , T. E. G. K. Murthy, B. Venkateswara Rao and V. Nikhila

Department of Pharmaceutical Analysis 1, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4145-51

4145-51

1661

497

29.

COMPARATIVE STUDY ON EFFECT OF OMEGA-3 FATTY ACID AND BONE MARROW MESENCHYMAL STEM CELLS ON COLD STRESS INDUCED NEURONAL CHANGES IN THE HIPPOCAMPUS OF RATS.

The present study aimed to compare the effect of Omega3 fatty acids (OFA) and bone marrow mesenchymal stem cells (BMSC’s) on stress induced neuronal degeneration in CA1 hippocampus region of rats. For isolation and culture of BMSCs, a three week old Wistar rat was sacrificed, femora and tibiae were collected then mesenchymal cells cultured. The 6th passage cells are analyzed by flow cytometry fo...

Karthikeyan Murthykumar , Saravana Kumar Sampath Kumar *

Department of Anatomy, Saveetha Dental College, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4152-56

4152-56

2268

502

30.

DRUG PRESCRIPTION PATTERN OBSERVATION AT A ENT OPD DEPARTMENT IN A TERTIARY CARE HOSPITAL AT MALAPPURAM DISTRICT OF KERALA

Affordability to healthcare is one of the major factors that have impact on the health care access in the Indian subcontinent. It is the main responsibility of the pharmacist in ensuring that patients get the right drug in the right quantity at the right time. Thus, such prescription pattern monitoring studies can promote appropriate use and reduction of abuse or misuse of monitored drug. The aim ...

A. Anandhasayanam *, S. Kannan, Mohammed Sajir and Nanisha Zachariah

Department of Pharmacy Practice JKKMMRFS College of Pharmacy, Komarapalayam, Po Erode, Tamilnadu-638183, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4157-63

4157-63

3075

648

31.

SOLUBILITY ENHANCEMENT AND DEVELOPMENT OF DISPERSIBLE TABLET OF CANDESARTAN CILEXITIL

Candesartan Cilexitil is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan cilexitil is a BCS class II drug having low solubility and high permeability. Candesartan Cilexitil is a prodrug which is rapidly converted to the active drug, Candesartan, by ester hydrolysis during absorption from the gastrointestinal tract. The bioavailability of Candesartan...

A. V. Shrirao and S. Bhilegaonkar *

Department of Pharmaceutics, PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4164-69

4164-69

1636

500

32.

FORMULATION AND IN VITRO EVALUATION OF SOLID DISPERSION OF FLUCONAZOLE

The Goal of the present investigation was to design and evaluate gels for topical delivery of water insoluble antifungal agent Fluconazole with an aim to increase its penetration through skin and there by its flux. This is a broad spectrum imidazole derivative useful in the treatment of superficial and systemic fungal infections. The solubility of Fluconazole is increased by preparing solid disper...

Faizan Sayeed *, Aejaz Ahmed and Abdul Sayeed

MESCO College of Pharmacy, Hyderabad (T.S) India

DOI: 10.13040/IJPSR.0975-8232.7(10).4170-79

4170-79

2535

734

33.

ANTI-TUSSIVE ACTIVITY OF ETHYL ACETATE AND METHANOL EXTRACTS OF ADHATODA VASICA NEES

The present study was carried out to evaluate anti-tussive activity of ethyl acetate and methanolic extract of leaves of Adhatoda vasica Nees. As cough is a natural reflex expulsive defense mechanism of the body, it is the most common symptom of respiratory disease. Ammonium hydroxide and Sulphur dioxide induced cough models in mice were used for evaluation of antitussive activity of ethyl acetate...

Sweta Srivastava* and G. P. Choudhary

Department of Pharmacognosy, School of Pharmacy, DAVV, Indore, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4180-83

4180-83

1703

473

34.

COMPARATIVE STUDY ON MDA, SOD AND HbA1c LEVELS IN PATIENTS OF TYPE 2 DIABETES MELLITUS WITH RETINOPATHY AND WITHOUT RETINOPATHY

Background: Diabetes mellitus comprises a group of metabolic disorders that share the common phenotype of hyperglycemia, association with the biochemical alteration of glucose and lipid peroxidation. Abnormalities in metabolism, including elevated polyol pathway, increased non-enzymatic glycation, accumulation of AGEs, uncontrolled oxidative stress, protein kinase C activity (PKC) and the expressi...

Manish Kumar Verma *, Shashi Prabha Singh, Roshan Alam and Poonam Verma

Department of Biochemistry, Career Institute of Medical Sciences and Hospital, Lucknow, UP, India.

DOI: 10.13040/IJPSR.0975-8232.7(10).4184-90

4184-90

2426

713

35.

SPECTROPHOTOMETRIC DETERMINATION OF ETHAMBUTOL IN PURE AND PHARMACEUTICAL FORMS USING TRIPHENYL METHANE DYES

Simple and sensitive extractive spectrophotometric methods for the determination of Ethambutol in pure form and in pharmaceutical formulations using triphenyl methane dyes have been developed. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with triphenyl methane dyes viz., bromocresol green (BCG), bromocresol purple (BCP) and bromophenol b...

Sayanna , M. Jyothi, T. Veeraiah * and CH. Venkata Ramana Reddy

Department of Chemistry, SAP College, Vikarabad, Ranga Reddy Dist., Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4191-99

4191-99

2656

638

36.

ISOLATION AND IDENTIFICATION OF POLYTHENE BAGS DEGRADING BACTERIA FROM VISAKHAPATNAM DUMPING YARD

Most low density bags are made from polythene, a chemically inert compound consisting of carbon and hydrogen. Burning of this plastic waste and burying of the plastics releases harmful toxic material which is a major pollutant in environment. Degradation of waste plastics through microorganism is the alternative method to deal with such problems. In this present study low density polythene bags de...

S. Satyalakshmi *

Pharmaceutical Biotechnology Division, Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam- 530046, Andhrapradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4200-03

4200-03

2575

541

37.

DNA BINDING AND NUCLEASE ACTIVITY OF STRUCTURALLY CHARACTERIZED COPPER(II) COMPLEX

A mononuclear copper(II) complex [Cu(bpy)2(NO3)] NO3 H2O (bpy = 2,2’-bipyridine) has been synthesized and characterized based on physico-chemical spectral data. The complex is characterized based on electronic, IR and ESR spectroscopies.  The structure of the complex is determined by single crystal X-Ray crystallography. The complex crystallizes in monoclinic space group P-1.  Structural analy...

S. Chandrasekhar and K. Hussain Reddy*

Department of Chemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(10).4204-13

4204-13

1656

474

38.

A COMPARISON STUDY OF LIPOSOMES, TRANSFERSOMES AND ETHOSOMES BEARING LAMIVUDINE

The aim of this study was to compare the skin permeation of liposomes, transfersomes and ethosomes of lamivudine under non-occlusive conditions. The liposome and transfersomes prepared by thin film hydration method and ethosomes were prepared by slight modification on hot method. The Liposomal formulation (LP1) ethosomal formulation (ET2) and transfersomal (TF2) formulation showed highest entrapme...

C. K. Sudhakar *, S. Jain and R. N. Charyulu

Department of Pharmacy, Lovely professional University, Jalandhar, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4214-21

4214-21

6229

882

39.

FORMULATION AND EVALUATION OF ENCAPSULATED FLOATING BEADS CONTAINING THE FAMOTIDINE AS A MODEL DRUG

The aim of this research work was to formulate and optimize a floating drug delivery system of famotidine. In the present study, preparation of famotidine floating beads, in-vitro evaluation of Floating Drug Delivery System (FDDS), prediction of the release, and optimization of polymers ratio to match target release profile was investigated. An attempt was made to prepare oil entrapped floating be...

Puneet Kumar *, Ram Babu Sharma and Nishant Goutam

L. R. Institute of Pharmacy, Jabli-Kyar, District Solan, Himachal Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4222-29

4222-29

2098

461

40.

HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF ISOFLAVONES AGLYCONE IN INDONESIAN SOYBEAN

Soybean is one of the highest isoflavones source. Isoflavones are one type of phytoestrogen that have a chemical structure similar to estradiol, that’s why it can be used not only to inhibite but also to prevent many symptoms related deficiency of estrogen. However in the small intestine, isoflavones like genistin will be hydrolyzed by β-glucosidase and produce aglycone like genistein, this pro...

Mfawwaz *, N. Akbar , M. Pratama, A. Saleh and Mbaits

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, South Sulawesi, Republic of Indonesia

DOI: 10.13040/IJPSR.0975-8232.7(10).4230-33

4230-33

1852

599

41.

ANTIBACTERIAL ACTIVITY OF IN VITRO REGENERATED ROOTS OF BRYOPHYLLUM PINNATUM LAM. KURZ

In vitro antibacterial activity of Bryophyllum pinnatum (in vivo generated and in vitro regenerated roots) were analysed in this study. Traditional uses for these plants treat specific conditions or diseases. The present study examined the antibacterial activity using the disk diffusion method using Ethanolic & Methanolic extract as part of the process of understanding the chemistry, toxicity ...

Shinam Mukhija *, Chandra Gurnani and Vikram Kumar

Department of Biotechnology, IASE (D) University, Sardarshahar, Churu, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4234-39

4234-39

1974

692

42.

REVERSED-PHASE LIQUID CHROMATOGRAPHY WITH MASS DETECTION AND NMR CHARACTERIZATION OF SITAGLIPTIN DEGRADATION RELATED IMPURITIES

The current work on impurity profiling of Sitagliptin in its bulk drugs, included development of a stability- indicating reverse-phased liquid chromatographic method and its validation for the estimation of degradation related impurities (DRIs). Sitagliptin was subjected to acid and alkaline hydrolysis, H2O2 oxidation, thermal degradation and photolysis. Acid hydrolysis and H2O2 oxidation yielded ...

F. I. Farooqui* and R. B. Kakde

Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4240-45

4240-45

1575

565

43.

EFFECT OF ETHANOLIC EXTRACT OF LEAVES OF PASSIFLORA INSARNATA LINN. IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS

The worldwide prevalence of diabetes mellitus (DM) has risen dramatically over the past two decades; based on current trends, more than 360 million individuals will be having diabetes by year 2030. The present study was designed to investigate the hypoglycemic of effect of ethanolic extract of leaves of Passiflora insarnata linn. in streptozotocin-induced diabetes in rat. The pharmacological inves...

Vivek Tomar *, S. D. Tonpay and Shashi Alok

Department of Pharmacology, IPS, Gwalior, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(10).4246-52

4246-52

2198

480

44.

BIOSYNTHESIS AND BIOACTIVITY OF SILVER NANOBIOCONJUGATES FROM GRAPE (VITIS VINIFERA) SEEDS AND ITS ACTIVE COMPONENT RESVERATROL

The seeds of Vitis vinifera have been shown to have antioxidant, anticancer and antimicrobial properties due to the presence of rich bioactive phenolic components like resveratrol. The research deals with the synthesis of silver nanobioconjugates from the methanolic extract of grape seeds and the pure compound resveratrol. The presence of resveratrol was confirmed by HPLC analysis in methanolic ex...

R. Preethi and P. R. Padma

Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, India.

DOI: 10.13040/IJPSR.0975-8232.7(10).4253-62

4253-62

2032

548

45.

COMPARATIVE ANALYSIS OF HPTLC, SECONDARY METABOLITES AND ANTIOXIDANT ACTIVITIES OF TINOSPORA CORDIFOLIA STEM POWDERS

Aim of this study was to develop a HPTLC fingerprint profiles of Tinospora cordifolia stems powdered by different procedures viz; Sample 1 (fresh aqueous powder), 2 (freeze drying powder), 3 (aqueous freeze drying powder) and Sample 4 (dry powder). The study also includes qualitative, quantitative secondary metabolites and the antioxidant potential of all the samples. Result of various physiochemi...

Acharya Balkrishna, M. Hemanth Kumar and Ashish Kumar Gupta *

Patanjali Natural Coloroma (P) Ltd , Padartha, Haridwar, Uttarakhand, India

DOI: 10.13040/IJPSR.0975-8232.7(10). 4263-71

4263-71

2333

541

46.

PREVALENCE OF CONTAMINATING MICROORGANISMS IN ANTI-MALARIAL DRUGS SOLD IN CALABAR, CROSS RIVER STATE, NIGERIA

The challenges to ensure proper preparation, storage, preservation and distribution of drugs are enormous. Very often, this results in the production and distribution of contaminated drugs. The study, therefore aimed to evaluate the prevalence of contaminating microorganisms in anti-malarial drugs sold in Calabar, Cross River State, Nigeria.  This was carried out using standard microbiological pr...

B. E. Agbo *, I. A. Takon and M. O. Ajaba

Microbiology Department, Faculty of Biological Sciences, University of Calabar, P. M. B. 1115, Calabar, Nigeria

DOI: 10.13040/IJPSR.0975-8232.7(10).4272-77

4272-77

2157

535