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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 10 (2019) - Issue 3, March

Review Articles

 
Title
Views
PDF
Cited
1.

CUBIC LIQUID CRYSTALLINE NANOPARTICLES (CUBOSOMES): A NOVEL CARRIER FOR DRUG DELIVERY

Lyotropic liquid crystalline systems, such as reversed bicontinuous cubic phases acquire progressive attention because of their unique microstructure and physicochemical properties. Cubosomes were nanostructured liquid crystalline particles, formed from a certain group amphiphilic lipids in definite proportions in water and was stabilized with a triblock copolymer. Substances in use were biocompat...

B. A. Molly * and N. L. Prasanthi

Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).973-84

973-984

1864

833

2.

A CRITICAL REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEMS FOR MANAGEMENT OF INFLAMMATORY BOWEL DISEASE

Inflammatory bowel disease (IBD) refers to the inflammation of the colon and small intestine of the body, in which Crohn's disease and ulcerative colitis are the principal types of IBD. This article covers most of the information related to a drug delivery system for treatment regarding intestinal diseases more emphasized to inflammatory bowel diseases. Currently, using delivery systems for target...

M. Jaiswal * and S. K. Lanjhiyana

Institute of Pharmaceutical Sciences Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).985-92

985-992

1306

496

3.

ALZHEIMER’S DISEASE: A COMPREHENSIVE REVIEW

Alzheimer disease (AD) is the most common cause of dementia which affects more than 44 million individuals worldwide. It has been noticed that there is only symptomatic treatments are available to treat AD, but no cure exists. It is a neurodegenerative disease characterized by Alois Alzheimer’s in 1906, and neuro-degenerative diseases are one of the major concerns facing by the modern health car...

Surabhi and B. K. Singh *

Department of Pharmaceutical Sciences, Kumaun University, Bhimtal Campus, Bhimtal, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).993-00

993-1000

1265

524

4.

PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE OF BACOPA MONNIERI – AN ETHNOMEDICINAL PLANT

In recent times, the use of herbal products has increased tremendously in the developing as well as in developed countries. Bacopa monnieri is one of the most important medicinal plant that has been consumed for thousands of year as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative and anti-epileptic agent. For many years, a lot of commercial and medicinal researches have bee...

S. Lal * and B. Baraik

PG Department of Botany, Dr. Shyama Prasad Mukherjee University, Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1001-13

1001-1013

2429

665

5.

PHARMACOLOGICAL POTENTIAL OF GREEN ALGAE CAULERPA: A REVIEW

From the beginning of civilization, humans depend on the natural products for their food and as medical treatment. Diversity in various bioactive compounds from marine organisms has been tested for the multiple pharmacological effects. Marine algae are surviving in a competitive environment with developed defense strategies and significant levels of chemical structural diversity with a wide variet...

J. G. S. Kumar *, S. Umamaheswari, S. Kavimani and R. Ilavarasan

Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry, Pondicherry, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1014-24

1014-1024

1523

573

6.

HYDROTROPHY: NOVEL SOLUBILITY ENHANCEMENT TECHNIQUE: A REVIEW

Drug discovery and development plays a major role in the world and serves mankind. The major criteria to be considered and given importance in drug development is the solubility of a drug. Among all newly discovered chemical entities, about 40% of drugs fail to reach the market due to their poor aqueous solubility or lipophilicity. Poor solubility is not only a problem for formulation development ...

A. Majeed, S. N. Raza and N. A. Khan *

Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1025-36

1025-1036

1844

384

7.

DIABETIC RETINOPATHY: AN OVERVIEW

Diabetes mellitus is a merge of assorted disorders commonly arise with happening of hyperglycemia and glucose intolerance due to which there be a lack of insulin production will occur. The two major classes of diabetes mellitus are type 1 diabetes mellitus and type 2 diabetes mellitus. For the prevention and controlling the increase of glucose, medical science uses a large array of pharmaceutical ...

G. K. Brar and S. Kosey *

Department of Pharmacy Practice, ISF College of Pharmacy, Ghal Kalan, Moga, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1037-44

1037-1044

643

242

8.

DISPERSIBLE FORMULATION MAKEUPS FOR PEDIATRIC USE: A REVIEW

Childhood is characterized by periods of rapid growth, maturation, and development. There is a change in the magnitude of the dose required during childhood and adolescence. Thus, Paediatric practice requires a range of dosage forms that are acceptable at different ages and abilities and a range of strengths or concentrations allowing administration of the correct age-related dose. Literature show...

M. I. Maqbool, N. A. Khan* and M. T. Maqbool

Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1045-53

1045-1053

873

255

9.

AN IDENTIFICATION OF CROP DISEASE USING IMAGE SEGMENTATION

Agriculture forms a vital part of India’s economy. More than 50% of India’s population is dependent on agriculture for their livelihood. In India, many crops are cultivated, out of which wheat is one of the most important food grains that this country cultivates and exports. Thus it can be seen that wheat forms a major part of the Indian agricultural system and India’s economy. Hence, the ma...

K. V. Kumar * and T. Jayasankar

Department of Electronics & Communication Engineering, Karpagam Institute of Technology, Coimbatore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.10(3).1054-64

1054-1064

1695

377

10.

A REVIEW ON THE PHARMACOGNOSTICAL, ECOLOGY AND PHARMACOLOGICAL STUDIES ON MARINE RED ALGAE – HYPNEA VALENTIAE

Seaweeds are the potential marine living resources in the world. More than 20,000 seaweeds are distributed throughout the world, of which only 221 (1.1%) are commercially utilized, which includes 145 species for food and 110 species for phycocolloid production. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active...

S. Dhanalakshmi * and S. Jayakumari

Department of Pharmacognosy, Faculty of Pharmacy, Dr. M. G. R. Educational and Research Institute, Velappanchavadi, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1065-71

1065-1071

687

229

11.

POLYCYSTIC OVARIAN SYNDROME- A MULTIFACETED DISEASE: A REVIEW

Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine disorders in females of reproductive age. Globally, it has been found that PCOS affects 10% of reproductive-age women when using the NIH criteria for diagnosis, and up to 18% of reproductive-age women are diagnosed with PCOS as per the Rotterdam criteria. Mostly symptoms of PCOS include irregular menstrual cycles, signs of h...

M. Maqbool, I. Gani and M. I. Geer

Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1072-79

1072-1079

738

256

12.

COLON SPECIFIC DRUG DELIVERY SYSTEM: AN APPROACH TO TARGET COLONIC DISEASES

Drug as such, may not show the desired therapeutic effect; drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiasis, colonic cancer, local treatment of co...

N. R. Kar * and S. C. Dinda

School of Pharmaceutical Education and Research (SPER), Berhampur University, Bhanja Bihar, Berhampur, Ganjam, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1080-88

1080-1088

796

267

13.

PROTECTION OF MEDICINAL PLANTS: A LEGAL PERSPECTIVE IN THE STATE OF JAMMU & KASHMIR

The indigenous and traditional health care system based on the rich diversity of plants associated knowledge serves more than 70% of the Indian population. More than 7500 species of plants have been used in Indian medical traditions and over 2700 documented species of plants are used in classical medical systems of Ayurveda, Unani and Siddha. About 1800 plants are documented in various Ayurvedic t...

R. Mohi-ud-din and R. Ashraf *

Department of Anatomy (Tashreeh-ul-Badan), Kashmir Tibbia College, Hospital & Research Centre Taleemabad Shilvath Sonawari, Bandipora, Jammu & Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1089-94

1089-1094

732

264

14.

QUALITY BY DESIGN: THE TOOL FOR REGULATORY COMPLIANCE

QbD decrees the definition of a goal for the method and accentuates thorough evaluation and scouting of alternative methods systematically to obtain ideal method performance. QbD tools like risk assessment and design of the experiment, empowers better quality to be instilled into the analytical method and facilitate prior understanding and identification of variables affecting the method performan...

M. P. Venkatesh *, A. Philip and H. V. Gangadharappa

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1095-00

1095-1100

716

267

Research Articles

 
Title
Views
PDF
Cited
15.

FLAXSEED OIL AMELIORATES METHOTREXATE-INDUCED OXIDATIVE STRESS AND HEPTO-RENAL TOXICITY IN MALE RATS

This study aimed to investigate the protective effect of flaxseed oil against hepato-renal toxicity induced by methotrexate. Rats treated with methotrexate exhibited elevations in the levels of AST, ALT, ALP, γGT, LDH, urea, creatinine, uric acid, and bilirubin. Furthermore, the levels of MDA, NO and the relative ratio of the gene expression of COX-2 and iNOS were significantly increased, accompa...

N. A. Mohamed * and H. M. Abdou and A. G. Mohamed

Department of Zoology, Faculty of Science Alexandria University, Egypt.

DOI: 10.13040/IJPSR.0975-8232.10(3).1089-02

1101-1114

1005

402

16.

MODULATION OF mTOR RECEPTOR IN DIABETIC NEPHROPATHY BY SANTALIN A OF LAL CHANDAN (PTEROCARPUS SANTALINUS): AN IN-SILICO ASSESSMENT BY MOLECULAR DOCKING

Background: Diabetic nephropathy (DN) is a primary cause of end-stage renal disease globally. Activation of mTOR and reduced autophagy has been identified as one of the pathogenic pathways. The presently available drugs have been successful in inhibiting the mTOR signaling, but show low oral bioavailability and suboptimal solubility. Rapamycin is a selective inhibitor of mTOR, shown significant pr...

P. Shree, D. Yadav, V. K. Singh, R. Chaube and Y. B. Tripathi *

Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1103-09

1115-1121

1094

366

17.

EFFECT OF PROBIOTIC LACTOBACILLUS FERMENTUM MCC3216 ON PROGRESSION OF TYPE 2 DIABETES WITH THEIR ANTI-INFLAMMATORY ACTIVITY IN HIGH FRUCTOSE FED DIABETIC RATS

The antidiabetic and anti-inflammatory effects of probiotic Lactobacillus fermentum MCC3216 was investigated in high fructose-fed type 2 diabetic rats. Type 2 diabetes was induced by feeding high fructose diet to male albino Wistar rats. A single daily dose of 2 × 108 CFU/ml of L. fermentum MCC3216 was given to Wistar rats for 8 weeks. The fasting blood glucose, body weight, oral glucose toleranc...

B. Mahajan *, S. K. Snehi and V. Singh

Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1110-20

1122-1132

895

409

18.

INDUCED COAGULATION AS A COMPLICATION OF INFLAMMATORY REACTIONS IN MICE TREATED WITH MONOSODIUM GLUTAMATE

Monosodium glutamate (MSG) is a familiar food additive processed to enhance the taste. This work was carried out to investigate the effect of MSG on platelets profile and indices of thrombus formation together with the detection of some plasma inflammatory markers. The study used adult male mice divided into five groups: a control group and four groups treated with different doses of MSG (2, 4, 8 ...

G. M. Badr * and A. I. Algefare

Department of Biological Sciences, Faculty of Science, King Faisal University, Kingdom of Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.10(3).1121-25

1133-1137

841

329

19.

ROSMARINIC ACID LOADED CHITOSAN NANOPARTICLES FOR WOUND HEALING IN RATS

Drug release properties from dosage forms can be modified by using many rate controlling polymers. Such controlled release properties from carrier systems are desirable since efficient drug delivery is achieved. The aim of the present study was to develop efficient chitosan nanoparticles loaded with rosmarinic acid (RA) and evaluate its drug release properties and wound healing efficiency in rats....

T. U. Wani, S. N. Raza * and N. A. Khan

Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu & Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1126-35

1138-1147

1282

435

20.

DISCOVERY OF NEW ANTI-FUNGAL PHYTOCHEMICAL PDHC (PROPANE-DIYL-BIS-HEXAHYDRO-ISOCHROMENE) ISOLATED FROM ALTERNANTHERA SESSILIS LEAVES

This study reports the potential of Alternanthera sessilis leaves as antioxidant, antimicrobial, anti-inflammatory and anti-diabetic agent and also the characterization of a novel phytochemical from A. sessilis using bio-activity guided extraction. Antimicrobial property was studied against five bacterial pathogens, Escherichia coli (MTCC: 1687), Bacillus cereus (MTCC: 0430), Klebsiella pneumonia ...

R. D. V. Sundar, L. Ravi and S. Mythili *

Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1136-47

1148-1159

792

358

21.

EVALUATION OF THE AMELIORATIVE EFFECT OF ALPINIA OFFICINARUM METHANOL EXTRACT IN AN EXPERIMENTAL MODEL OF DEPRESSION

The active ingredient flavonoids especially Flavones, e.g., Quercetin was identified from the methanol extract of Alpinia officinarum. This study evaluates the antidepressant activity of Alpinia officinarum (L.) wild Hance (Zingiberaceae) in Swiss Albino mice models. The antidepressant activity was evaluated by using different animal models viz. tail suspension test, despair swim test, potentiatio...

D. M. Awari * and R. S. Somani

Department of Pharmacology, Smt. Kashibai Navale College of Pharmacy, Kondhwa, (Savitribai Phule Pune University), Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1160-71

1160-1171

590

237

22.

MICROWAVE-ASSISTED SYNTHESIS OF IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR ANTI-INFLAMMATORY ACTIVITY

A series of novel Imidazo[1,2-a]pyridine derivatives were synthesized in satisfactory yield by microwave assisted synthetic method. The structures of the newly synthesized compounds are characterized by 1H-nuclear magnetic resonance (NMR), Fourier transformed infrared (FTIR), mass spectral analysis (LC-MS) and screened for their in-vitro anti-inflammatory activity. Among the synthesized compounds ...

P. Budumuru *, S. Golagani and B. Pushpanjali

Department of Chemistry, Institute of Science, GITAM Deemed To Be University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1172-79

1172-1179

485

218

23.

ANTIDIABETIC POTENTIAL OF ABELMOSCHUS ESCULENTUS LINN. IN ALLOXAN- INDUCED DIABETIC RATS

Abelmoschus esculentus Linn. (Malvaceae) is described in medicine for the treatment of diabetes mellitus. The monech seeds of Abelmoschus esculentus having potential in the development of a drug for diabetes due to their antidiabetic activity. The hypoglycemic effect of the extract was tested in normal, glucose loading and alloxan-induced diabetic rats. Aqueous and ethanolic extracts (250 and 500 ...

N. Jain*, R. Jain and S. K. Jain

Sagar Institute of Research Technology & Science-Pharmacy, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1180-85

1180-1185

767

225

24.

STUDY OF FORCED DEGRADATION BEHAVIOUR OF A NOVEL PROTEASOME-INHIBITING ANTICANCER DRUG BY LC-MS AND DEVELOPMENT OF A VALIDATED STABILITY-INDICATING ASSAY METHOD

In the present study, comprehensive stress testing of Carfilzomib, a newly approved proteasome-inhibiting anticancer drug was carried out according to ICH guideline Q1A (R2). The drug was subjected to acid (0.1N HCl), neutral and alkaline (0.1N NaOH) hydrolytic conditions at 70 ºC, as well as to oxidative decomposition at room temperature. Photolysis was carried out in 0.1N HCl, water and 0.1N Na...

B. A. Agarwal * and S. V. Gandhi

Department of Pharmaceutical Chemistry, A.I.S.S.M.S College of Pharmacy, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1186-93

1186-1193

770

351

25.

IDENTIFICATION OF ACTIVE PHARMACEUTICALS OF SIDA ACUTA BURM. F. LEAVES USING GC-MS AND HPTLC FINGERPRINTING

Sida acuta is one of the medically active plants used for the treatment of multifaceted diseases. However, an elaborated investigation on the phytochemical composition of the ethanolic extract of the leaves of this plant is yet to be deciphered. So, in this quantification of phytochemicals, in-vitro free radical scavenging activity, enzymatic and non-enzymatic antioxidant levels in the fresh leave...

P. Muneeswari, S. K. Bhaskaran and K. Poornima *

Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1194-07

1194-1207

1150

269

26.

FORMULATION AND IN-VITRO CHARACTERIZATION OF AMBROXOL HYDROCHLORIDE SUSTAINED-RELEASE MATRIX TABLETS

The present study involves the formulation and in-vitro characterization of sustained release matrix tablets of Ambroxol hydrochloride, a potent mucolytic agent used in the treatment of respiratory disorders. FTIR analysis confirmed the absence of drug-polymer interactions. Sustained release matrix tablets containing 75 mg were formulated employing HPMCK15 and xanthan gum as release retarding poly...

S. Jaya * and G. Srilaxmi

Department of Pharmaceutics, Anurag Pharmacy College, Ananthagiri, Kodad, Suryapet, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1208-13

1208-1213

1025

246

27.

AN EFFICIENT SYNTHESIS OF SOME NOVEL BIOACTIVE AZETIDINONE DERIVATIVES INCLUDING 5-(BENZOFURAN-2-YL) AND 1-PHENYL-1H-PYRAZOLE-3-CARBOXAMIDE MOIETY

In continuation of our efforts in the development of novel drugs, in the present article we have described synthesis of a series of novel azetidinones derivatives (4a-i) containing 5-(benzofuran-2-yl) and 1-phenyl-1H-pyrazole-3-carboxamide moiety, with excellent yields and without formation of undesirable side products from cyclo condensation reaction of N'- (benzylidene) -5- (benzofuran- 2- yl) -...

M. Idrees *, S. Kola and N. J. Siddiqui

Department of Chemistry, Government Institute of Science, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1214-22

1214-1222

555

245

28.

ANTIBACTERIAL AND ANTIVIRAL PROPERTIES OF SILVER NANOPARTICLES SYNTHESIZED BY MARINE ACTINOMYCETES

Present work has been conducted to evaluate antibacterial and antiviral activity of silver nanoparticles using marine Actinomycete, Nocardiopsis alba, isolated from mangrove soil. Formation, size, and shapes of silver nanoparticles (AgNPs) were characterized by UV-visible spectroscopy, X-Ray Diffraction (XRD), FTIR and Transmission electron microscope (TEM). From the UV-visible spectroscopy, the a...

J. Avilala and N. Golla *

Department of Virology, Applied Microbiology Laboratory, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1223-28

1223-1228

2231

318

29.

A NOVEL RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DICYCLOMINE AND ETHYL MORPHINE IN BULK AND PHARMACEUTICAL FORMULATION

The present study was designed to develop and validate a simple, sensitive, precise and accurate RP-HPLC method for simultaneous estimation of dicyclomine and ethylmorphine in bulk and tablet dosage form. The chromatographic separation was achieved on Discovery C18 column (250 × 4.6 mm, 5 µm) as stationary phase with a mobile phase of water (pH 5.4 adjusted with orthophosphoric acid): acetonitri...

A. Gundala *, D. S. Kammuri and P. Chengalva

Department of Pharmaceutical Analysis and Quality Assurance, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1229-34

1229-1234

736

269

30.

PHYTOCHEMICAL, CYTOTOXICITY AND DOCKING STUDIES OF SAMANEA SAMAN

Samanea saman is a tropical avenue tree which is widely cultivated in Northern America, and Asia belongs to the family Leguminosae. It possesses a wide range of biological perspectives. Folklore claims postulated that Samanea saman is having an antiulcer, antioxidant antibacterial and anti-mycobacterial properties. In the present investigation, the methanol extract of leaves of Samanea saman has b...

G. S. Kumar * and S. D. S. Kumaran

Seven Hills College of Pharmacy, Venkatramapuram, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1235-40

1235-1240

709

279

31.

IN-SILICO DOCKING ANALYSIS OF PHYTOCHEMICALS FROM VERBASCUM PHLOMOIDES L. AS AN ANTIVIRAL AGENTS AGAINST HERPES SIMPLEX VIRUS TYPE I AND TYPE II

Almost 85% of the world population is infected with the Herpes Simplex Virus (HSV). Herpes simplex virus infections have been described in the medical literature for centuries, yet the drugs available nowadays for therapy are largely ineffective and low oral bioavailability plays an important role on the inefficacy of the treatments. Additionally, the details of the inhibition of Herpes virus type...

M. A. Bhuvad and L. R. Samant *

Molecular Genetics Research Lab, B. J. Wadia Hospital for Children, Parel, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1241-45

1241-1245

705

213

32.

BIOCONVERSION OF ORANGE PEEL WASTE BY ESCHERICHIA COLI AND SACCHAROMYCES CEREVISIAE TO ETHANOL

An alternative energy sources using the sweet orange (Citrus sinensis (L.) waste as the feedstock was investigated; this is an approach to environmental protection. The extraction of pectin from sweet orange peel waste (pith) and the production of ethanol from the resultant liquid pectin with the aid of Escherichia coli (E. coli) and Saccharomyces cerevisiae (yeast) were carried out. Dried pith wa...

M. E. Ojewumi *, M. E. Emetere, C. V. Amaefule, B. M. Durodola and O. D. Adeniyi

Department of Chemical Engineering, Covenant University, Sango Ota, Ogun, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.10(3).1246-52

1246-1252

789

230

33.

ANALYSIS OF CUTANEOUS ADVERSE DRUG REACTIONS PRESENTING TO THE DERMATOLOGY DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL: A PROSPECTIVE, OBSERVATIONAL STUDY

Background: Cutaneous adverse drug reactions (CADRs), having a wide range in terms of its spectrum, are an important cause of morbidity and mortality. They comprise 2-3% of all ADRs. This study was conducted to analyze various parameters of CADRs at our setup. Methodology: This prospective, observational study was carried out for 1 year at our setup after ethical approval. Those diagnosed as CADRs...

H. J. Sheth, R. P. Patel, R. G. Chaudhary and S. D. Malhotra *

Department of Pharmacology, Smt. NHL MMC, Ellisbridge, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1253-58

1253-1258

617

224

34.

ANTI-ATHEROSCLEROTIC BIOACTIVE COMPOUND FROM A MARINE MOLLUSC, CHICOREUS SP.

This study reports the potential of a marine mollusk, Chicoreus sp., as a producer of peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand that activate the scavenger receptor class B type 1 (SR-B1) for anti-atherosclerotic activity. The objective of this study is to determine the cytotoxicity of the obtained compound C35, with a molecular weight of 270.1 and the level of SR-B1 expres...

N. M. Sarizan, F. Mohamad, N. Ismail *, L. Abu-Bakar and T. S. T. Muhammad

Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.10(3).1259-62

1259-1262

677

192

35.

QUALITY ASSESSMENT OF VRANROPAN TAILA: AN AYURVEDIC SIDDHA TAILA FOR WOUND HEALING AND ANTI-MARK PROPERTY

Standardization can create trust and confidence in the products and increase market relevance. It is an essential requirement for the open exchange of information; without it, the network will simply not work. The practitioner, as well as the consumer, now seeks assurance from the manufacturer about the quality, safety, and efficacy of a readymade Herbal supplement or Ayurvedic formulations. An av...

K. N. Yadav *, P. V. Kadam, C. L. Bhingare and M. J. Patil

Marathwada Mitra Mandal’s College of Pharmacy, Kalewadi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1263-68

1259-1262

1881

244

36.

QUANTITATIVE ESTIMATION OF TOTAL PHENOLIC CONTENT OF TWO SPECIES OF PORTULACA OBTAINED BY USING MICROWAVE ASSISTED EXTRACTION AND ITS VALIDATION

Portulaca oleracea and Portulaca quadrifida have been used traditionally have been used for their pharmacological properties and consumed as a part of the diet. Anti-oxidative property of phytochemicals might play a role in their observed benefits, and phenolic compounds are known to be the major contributors towards the anti-oxidant property of phytochemicals. The objective of this study was to q...

T. P. Dugawale *, C. C. Khanwelkar and P. P. Durgawale

Department of Pharmacology, Krishna Institute of Medical Sciences Deemed to be University, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1269-74

1269-1274

529

195

37.

PROTECTIVE EFFECTS OF ALOE VERA AGAINST RADIATION INDUCED BIOCHEMICAL DISORDERS IN LIVER OF SWISS ALBINO MICE

In this study, radioprotection against radiation-induced hepatic damage in Swiss albino mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals. Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation...

P. Dadupanthi

Department of Zoology, University of Rajasthan, Jaipur, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1275-80

1275-1280

494

193

38.

FORMULATION AND EVALUATION OF LIQUISOLID COMPACT OF CANDESARTAN WITH β-CYCLODEXTRIN

The liquisolid technique was chosen to enhance the dissolution properties of Candesartan. The study aimed to investigate the complexation of Candesartan with β-cyclodextrin in improving the dissolution profile of Candesartan. Candesartan is a BCS class-II drug. The inclusion complexes were formed by physical mixing (1:1 ratio). Liquisolid compacts were prepared by using, propylene glycol, tween 2...

R. R. Pile * and S. Z. Chemate

Department of Pharmaceutics, Dr. V. V. P. F’s College of Pharmacy (Savitribai Phule Pune University), Ahmednagar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1281-88

1281-1288

881

208

39.

FORMULATION AND EVALUATION OF FLOATING GEL BEADS OF LORATADINE

A floating controlled drug delivery system of loratadine was formulated to enhance the retention time in the stomach and to modify the release characteristics of loratadine. Loratadine loaded floating gel beads were prepared by ionic gelation technique using different polymers such as HPMC K4M, HPMC K15M, and carbopol 934P in different proportions and sodium bicarbonate as the gas forming agent. F...

S. A. Begum *, J. Jhansi and K. Padmalatha

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1289-99

1289-1299

655

226

40.

DEVELOPMENT AND VALIDATION OF A HPLC ANALYTICAL METHOD FOR DETERMINATION OF ELLAGIC ACID IN EPILOBIUM ANGUSTIFOLIUM EXTRACT

Development of quality assessment parameters for natural products is a prominence necessity to justify their acceptability and activity. Establishment of authentic and reliable analytical methods which profile the quantitative phytochemical composition of marker constituents in multicomponent composition like extract is a challenging task. A simple, rapid, precise, and reliable HPLC method was dev...

P. V. Kadam *, K. N. Yadav, C. L. Bhingare and M. J. Patil

Marathwada Mitramandal’s College of Pharmacy, Thergaon, Kalewadi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1300-06

1300-1306

810

262

41.

PRODUCTION OF XYLANASE BY PENICILLIUM SP. AND ITS BIOBLEACHING EFFICIENCY IN PAPER AND PULP INDUSTRY

The main objective of this study is to evaluate the ability of production of xylanase by a fungal strain Penicillium sp. isolated from decaying wood. Xylanases are hydrolytic enzymes produced by many microorganisms which catalyze the hydrolysis of xylan polymer to xylose monomer. The xylanase production was carried out under submerged fermentation xylose as the main substrate, and the enzyme yield...

A. Sridevi *, G. Narasimha and P. S. Devi

Department of Applied Microbiology, Sri Padmavati Mahila University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1307-11

1307-1311

843

247

42.

IDENTIFICATION AND HPLC QUANTIFICATION OF AFLATOXINS IN GROUNDNUT (ARACHIS HYPOGAEA L.) SAMPLES COLLECTED IN RAYALASEEMA AREA, ANDHRA PRADESH

The present investigation reports the fungal Aflatoxins contamination in groundnut samples collected in different locations in the Rayalaseema area, Andhra Pradesh, India. Aflatoxins were extracted by liquid-liquid extraction method using chloroform solvent. The qualitative and quantitative analysis of aflatoxins present in the samples was done using TLC and HPLC techniques. Among the eight sample...

S. Ommi, M. Medikonda * and K. Gudela

Department of Chemistry, PB Siddhartha College, Vijayawada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1312-18

1312-1318

811

225

43.

ASSESSMENT OF PRESCRIBING PATTERN OF ANTIEPILEPTICS IN PAEDIATRIC IN-PATIENTS OF A TERTIARY CARE HOSPITAL

Purpose: To study the prescribing pattern of AEDs for a different type of seizures in the pediatric population and disease conditions other than epilepsy and to identify the drug interactions with the use of AEDs among the study population. Methods: This six months long prospective observational study was conducted at in-patient wards of JSS Hospital. The case sheets of all in-patients were review...

J. Sebastian, M. F. Mathew, P. Amuktha, A. Chacko and D. Narayanappa

Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, SS Nagara, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1319-24

1319-1324

517

192

44.

SCIENTIFIC EVALUATION OF VALLI PANCHMOOLA – DIFFERENT COMPOSITIONS THROUGH PHARMACOGNOSTICAL AND PHYTOCHEMICAL METHODOLOGY

Objective: This study aimed at ensuring the different compositions of Valli panchmoola using authentic herbs and establishing pharmacognostical, physicochemical, and phytochemical standards for the compositions. Methods: Compositions of Vallli panchmoola were prepared as per the formula and procedure mentioned in traditional texts and Ayurvedic Formulary of India. The prepared compositions were ev...

U. B. Ashani *, C. R. Harisha and V. J. Shukla

Department of Pharmacognosy Lab, IPGT & RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1325-29

1325-1329

543

226

45.

SPECTROPHOTOMETRIC DETERMINATION OF ETODOLAC USING CHARGE TRANSFER COMPLEX

In this study, we developed a cheap and precise analytic method to measure Etodolac concentration in bulk and pharmaceutical formula. The modified, updated method depends on the reaction between ferric ion and Etodolac to yield ferrous ion. Then the former ion reacted with potassium ferric cyanide to form colored compound has a maximum absorbance at 700 nm. The method was validated by calculating ...

A. M. Mahood and S. L. Alkhafaji *

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Kerbala, Iraq.

DOI: 10.13040/IJPSR.0975-8232.10(3).1330-35

1330-1335

550

200

46.

ASSOCIATION BETWEEN VITAMIN D RECEPTOR FOKI POLYMORPHISM AND CHRONIC PERIODONTITIS IN SYRIAN POPULATION

Background: Chronic periodontitis (ChP) is the most common form of periodontal diseases. The progression rate may be influenced by local, systemic conditions and environmental factors that can alter the normal host response to bacterial plaque and affect the susceptibility to disease. Several studies have reported a role for vitamin D receptor (VDR) gene polymorphisms in numerous immunological act...

F. Kafa *, A. A. Sulaiman and S. Haddad

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Syria.

DOI: 10.13040/IJPSR.0975-8232.10(3).1336-41

1336-1341

523

198

47.

EVALUATION OF α-AMYLASE AND α-GLUCOSIDASE ENZYME INHIBITORY ACTIVITIES OF TRICHURIELLA MONSONIAE BENNET

Diabetes is a noncommunicable chronic metabolic disorder characterized by high blood glucose level in the body. One of the antidiabetic therapeutic strategies is the inhibition of carbohydrate-digesting enzymes such as α-amylase and α-glucosidase. In the present study methanolic extract and its two fractions (Ethyl acetate and n-butanol) of the whole plant of Trichuriella monsoniae were evaluate...

S. R. Vanapatla * and F. Begam

Department of Pharmacognosy and Phytochemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1342-46

1342-1346

839

228

48.

PHYTOCHEMICALS AND IN-VITRO ANTIOXIDANT ACTIVITY OF HALOPHILA BECCARII

Free radicals induce numerous diseases by lipid peroxidation, oxidation of monosaccharides and DNA damage. In the present study, the marine plant seagrass Halophila beccarii was exploited to detect the phytochemical constituents and its antioxidant potential. The aqueous and organic extracts of Halophila beccarii portrayed the presence of various metabolites such as phenolic compounds, flavonoids,...

M. Vani, S. D. S. Murthy and P. U. M. Devi *

Department of Applied Microbiology & Biochemistry, Sri Padmavathi Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1347-53

1347-1353

651

248

49.

FORMULATION, EVALUATION AND CYTOTOXIC POTENTIAL OF METRONIDAZOLE LOADED POLOXAMER 407 HYDROGEL IN SCC-29 CELL LINES

The present research work was planned to formulate poloxamer 407 based hydrogel formulations of metronidazole and the evaluation of various parameters like swelling behavior, drug PH stability, in-vitro and in-vivo drug release, and in-vitro cytotoxic activity. Two different concentrations of metronidazole hydrogel formulations were prepared using poloxamer 407 and were assessed by a validated HPL...

P. Katakam, S. R. Banapuram * and S. K. Adiki

Vikas College of Pharmacy, Janagaon, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1354-59

1354-1359

539

196

50.

TRANSMISSION OF HEPATOCURATIVE EFFECT OF SPILANTHES ACMELLA EXTRACT BASED GEL

Spilanthes acmella (SA) commonly known as “Akarkara” frequently available in most of the areas of India, Sri Lanka, Bangladesh, China, Japan, and Thailand; is well reputed in the indigenous system of medicine for its medicinal use in toothache and rheumatic fever. The present study was aimed to evaluate its traditional use in liver diseases using the in-vivo model of rabbits. The Spilanthes ac...

A. Mumtaz, S. N. H. Shah, M. Zabta, M. M. Ayaz, H. Javed * and N. Bashir

Faculty of Pharmacy, Department of Pharmaceutics, Bahauddin Zakariya University Multan, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.10(3).1360-65

1360-1365

667

209

51.

EFFICACY OF TWO AYURVEDA DRUG REGIMENS FOR UTERINE FIBROIDS, A RANDOMIZED, SINGLE BLIND, THREE-ARM, CLINICAL TRIAL- STUDY PROTOCOL

Uterine fibroids are the most common genital tract tumor in reproductive age women. The main treatment option for fibroid is surgical intervention. Options for medical therapy are currently limited to preoperative reduction of symptoms related to uterine bleeding and fibroid size. Ayurveda treatment for this condition is widely practiced in Sri Lanka. We aimed to evaluate the efficacy of two Ayurv...

K. Karunagoda, P. K. Perera * and H. Senanayake

Department of Ayurveda Pharmacology and Pharmaceutics, Institute of Indigenous Medicine, University of Colombo, Rajagiriya, Sri Lanka.

DOI: 10.13040/IJPSR.0975-8232.10(3).1366-71

1366-1371

1302

306

52.

ANALYSIS OF QUORUM QUENCHING POTENTIAL OF EUPHORBIA TRIGONA MILL.

S. marcescens and P. mirabilis are gram-negative bacteria responsible for nosocomial infections. Quorum sensing regulates virulence in S. marcescens and P. mirabilis. Present study documents the potential of E. trigona extracts in inhibiting quorum sensing in both the bacterial species. Extracts of aerial part of the plant were prepared in petroleum ether, chloroform, ethyl acetate, acetone and me...

K. Marathe *, N. Nashikkar, S. Bundale and A. Upadhyay

Hislop School of Biotechnology, Hislop College, Temple Road, Civil Lines, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1372-86

1372-1386

915

248

53.

METHOD DEVELOPMENT AND VALIDATIONS OF APIXABAN IN BULK AND ITS FORMULATIONS BY UV-SPECTROSCOPY (AREA UNDER CURVE)

The aim of the present research work is to validate the apixaban content in bulk and pharmaceutical dosage formulation and validate it as per ICH guidelines. A simple, rapid, precise and highly selective spectrophotometric method was developed for estimation of apixaban in tablet dosage form by the area under curve method. The area under curve method involves the measurement of absorbances of apix...

M. A. Haque, V. Bakshi, N. Boggula * and S. P. Dandamudi

Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1387-91

1387-1391

778

226

54.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF HALOBETASOL PROPIONATE AND MUPIROCIN IN THE RATIO 1:40 BY U.V. SPECTROSCOPY AND RP- HPLC METHOD

The present work encompasses the development of two classical UV spectroscopy methods and an RP-HPLC method for the concurrent assessment of Halobetasol propionate and Mupirocin inculcating a statistical approach. The UV spectroscopy methods developed herein include absorption ratio method and first derivative spectroscopy method. The wavelength maxima selected for Absorption ratio method were 240...

A. Bana *, M. A. Sathe and S. J. Rajput

Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery Systems, Pharmacy Department, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1392-01

1392-1401

1243

306

55.

FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILMS OF LOSARTAN POTASSIUM USING 32 FACTORIAL DESIGN

The objective of the present study was to develop mouth dissolving films (MDF) of Losartan potassium for the treatment of hypertension, with fast disintegration, optimum morphological properties, and mechanical strength. Losartan is an anti-hypertensive drug which undergoes extensive first-pass metabolism that results in low bioavailability of the drug. Through buccal route, the drug directly ente...

S. N. Raza, A. H. Kar, T. U. Wani, and N. A. Khan *

Department of Pharmaceutical Sciences, School of Applied Science and Technology, University of Kashmir, Srinagar, Jammu & Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1402-11

1402-1411

1261

276

56.

PROTECTIVE EFFECT OF BAUHINIA TOMENTOSA L. EXTRACT AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN WISTAR MALE ALBINO RATS

The aim of the present study was to explore the effect of aerial parts of Bauhinia tomentosa extract against gentamicin-induced nephrotoxicity. Thirty male Wistar albino rats were divided into five groups of six animals each. Animals served as Group I (normal control 5 ml/kg b.wt, p.o), Group II (toxic control), and Group III and IV (treatment groups 200 and 400 mg/kg b.wt, p.o) and Group V (stand...

N. Akhitha, M. Raghavendra * and M. V. K. Kumar

Department of Pharmacology, CMR College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1412-19

1412-1419

726

196

57.

METABOLIC SYNDROME: PREVALENCE (IDF & NCEP-ATP III) IN UDHAMPUR, JAMMU CITY

Aim: To determine the prevalence of metabolic syndrome in Udhampur, J & K population according to two different criteria’s (IDF & NCEP-ATP III). Methods: A cross-sectional survey was conducted for the prevalence of metabolic syndrome among 210 participants. A pre-designed questionnaire was used to collect data, including demographic information; physical activity and biochemical paramete...

R. Sharma *, R. Sharma and A. Kumar

MCM DAV College, Chandigarh, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1420-25

1420-1425

834

239

58.

IN-VITRO ANTIOXIDANT POTENTIAL OF SELECTED NUTRACEUTICALS

The current study involves evaluation of antioxidant potential of selected nutraceuticals like barley grass juice (Hordeum vulgare L.), ethanolic extracts of cashew apple (Anacardium occidentale L.) and sea lettuce (Ulva reticulata F.) in in-vitro experimental model using goat liver slices at different concentrations (100, 200, 400, 800 and 1600 mg/kg, p.o). The oxidative stress was induced using ...

T. Jhansyrani, D. Sujatha, P. Rupasree, K. Bharathi and K. V. S. R. G. Prasad *

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1426-32

1426-1432

657

183

59.

COMPARATIVE ANTIANXIETY POTENTIAL OF EUPHORBIA NERIIFOLIA LINN. LEAVES AND EUPHORBIA HIRTA LINN. AERIAL PARTS

Euphorbia neriifolia and Euphorbia hirta have been traditionally used for relieving anxiety and other nervous disorders. The present study was designed to evaluate and compare the antianxiety activity of E. nerrifolia leaves and E. hirta aerial parts using elevated plus maze model. Petroleum ether (60-80°C), chloroform, ethanol and aqueous extracts of both the plants were prepared and evaluated f...

Gulsheen, A. Kumar * and A. Sharma

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1433-38

1433-1438

584

205

60.

HIGHLY SELECTIVE AND SENSITIVE DETERMINATION OF Cr6+ (nM) IN GELATIN CAPSULE USING AgF/Ag2WO4 NANOCOMPOSITE

The present work deals with a novel synthesis of AgF/Ag2WO4 nanocomposite by co-precipitation method. The morphology and size of the synthesized AgF/Ag2WO4 nanocomposite were confirmed by Ultraviolet-Visible (UV-Vis) spectroscopy, Fourier Transform-Infrared (FT-IR) spectroscopy, Transition Electron Microscopy (TEM) and X-Ray Diffraction (XRD) analyses. The performance of the nanocomposite was succ...

R. Arumugam and P. Periakaruppan *

Department of Chemistry, Thiagarajar College, Madurai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1439-47

1439-1447

492

247

61.

ENHANCED MECHANISM OF METAL NANOPARTICLES USING SYZYGIUM CUMINI AS A POTENTIAL SYNTHESIZER AND ITS INHIBITORY EFFECT

In recent years metallic nanoparticles, represent one of the most comprehensively studied materials because of their application in biology The synthesis of silver nanoparticles using biological entities has received immense attention in the area of research. Medicinal plants have attracted interest over antibiotics due to a rapid increase in the rate of infections, development of antibiotic resis...

R. Anburaj * and V. Jothiprakasam

Department of Microbiology, MIET Arts and Science College, Affiliated to Bharathidasan University, Tiruchirapalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1448-54

1448-1454

490

186

62.

PHARMACOKINETIC STUDIES OF SECNIDAZOLE IN THE PRESENCE OF PIPERINE AND ITS SYNTHETIC DERIVATIVE

Piperine has been widely used as a bioenhancer. Secnidazole is a long-acting 5-nitroimidazole analog. It is used in the treatment of amoebiasis, giardiasis, trichomoniasis and anaerobic bacterial infection. In this study derivative of piperine was synthesized and studied for its bio enhancing the effect and this effect was compared with the bioenhancing effect of piperine. The pharmacokinetic prof...

P. Auti, S. Gabhe * and K. Mahadik

Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1455-61

1455-1461

731

217

63.

FORMULATION AND EVALUATION OF TOOTHPASTE CONTAINING COMBINATION OF ALOE AND SODIUM CHLORIDE

The formulation and evaluation of toothpaste contain Aloe vera along with the combination of sodium chloride. Aloe vera shows a number of uses either internally or externally, and the number of uses also increases as the research going on. In this formulation, we tried to find out the antimicrobial activity of Aloe vera in toothpaste formulation, for the said purpose we use S. aureus culture. Afte...

P. L. Phalke *, T. G. Rukari and A. S. Jadhav

VJSM’s Vishal Institute of Pharmaceutical Education and Research, Ale, Junnar, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1462-67

1462-1467

2042

396

64.

DRUG UTILISATION EVALUATION OF CORTICOSTEROIDS IN TERTIARY CARE TEACHING HOSPITAL

Objective: Steroids are widely prescribed and used by practitioners due to powerful anti-inflammatory and immunosuppressive actions. So, care should be exercised in the rational selection of steroids. The main aim of our study is to assess prescribing patterns, demographic and clinical variables such as drug interactions associated with corticosteroid administration and steroidal use in a tertiary...

M. Thadanki *, C. P. Kumar, M. Tejaswi, R. Baburao and K. Charitha

Department of Pharmacy, Southern Institute of Medical Sciences, Managaladas Nagar, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1468-76

1468-1476

785

262

65.

THE SYNTHESIS OF QUINAZOLON-1,3,4-OXADIAZOLE ANALOGUES AND STUDIES OF THEIR ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY

A series of conjugation of two heterocycles 1, 3, 4-oxadiazole and quinazolone were synthesized and screened for antimicrobial as well as antioxidant activity. Compound4-(4-oxo-2-phenyl-quinazoline-3(4H)-yl)-benzohydrazide 3 on cyclization with different aromatic acids in the presence of phosphoryl chloride (POCl3) give different 1, 3, 4-oxadiazole derivatives. Similarly, compound 3 on reaction wi...

V. S. Kulkarni *, D. S. Chavan and G. P. S. Kumar

Department of Pharmaceutical Chemistry, Indira Institute of Pharmacy, Sadavali (Devrukh), Ratnagiri, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1477-84

1477-1484

649

223

66.

DEVELOPMENT OF MALTODEXTRIN BASED PRONIOSOMES DERIVED NIOSOMES OF OFLOXACIN

Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery. The advance in nanotechnology helps in the preparation of new pharmaceutical formulations with high benefits. One of its approaches is to stabilize the niosomal drug delivery system without affecting its properties have resulted in the development of proniosomes,...

G. S. Ravi *, A. Dubey and S. Hebbar

Department of Pharmaceutics, N. G. S. M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1485-90

1485-1490

652

225

67.

DESIGN AND DEVELOPMENT OF DANTROLENE SPHERICAL AGGLOMERATES FOR IMPROVEMENT IN BIOAVAILABILITY

The purpose of this research was to obtain directly compressible agglomerates of Dantrolene using spherical agglomerates. Spherical agglomeration technique enables simultaneous crystallization and agglomeration. Sodium hydroxide acted as a good solvent, aqueous solution of PEG 6000 in hydrochloric acid served as bad solvent and isopropyl acetate was used as bridging liquid. The optimization of for...

P. V. Kamble * and F. J. Sayyad

Government College of Pharmacy, Karad, Vidyanagar, Karad, Satara, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1491-00

1491-1500

522

220

68.

DESIGN AND DEVELOPMENT OF ANTI-DIABETIC TABLET FORMULATION CONTAINING SPRAY DRIED EXTRACT OF MULBERRY LEAVES

Diabetes is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. The chronic hyperglycemia in diabetes is associated with long term damage, dysfunction, failure of kidney, nerves and blood vessel. Nowadays, herbal treatments available for diabetics are eroding the share of allopathic formulations. Cur...

A. K. Pujari * and N. R. Jadhav

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1501-09

1501-1509

747

278

69.

EFFECT OF METFORMIN AND ROSUVASTATIN ON ERYTHROCYTES OF PATIENTS WITH SICKLE CELL DISEASE: AN IN-VITRO STUDY

Objectives: Sickle cell disease (SCD) is a common hereditary blood disease with a progressive clinical course and multiple end organs damage. Due to its intercalated pathophysiology, several trials have been conducted targeting its pathophysiology in an attempt to modify the clinical course and minimize complications. Metformin and rosuvastatin are known to have pleiotropic effects such as antioxi...

S. F. Abbas * and J. H. Ahmed

Department of Pharmacology, College of Medicine, University of Basrah, Iraq.

DOI: 10.13040/IJPSR.0975-8232.10(3).1510-17

1510-1517

613

179

70.

ESTIMATION OF PROTEINS IN PLANTS OF FORENSIC SIGNIFICANCE (RICINUS COMMUNIS AND CANNABIS SATIVA) BY UV-SPECTROPHOTOMETRY AND GEL ELECTROPHORESIS METHOD

Proteins play a significant role in living beings. In animals, where proteins are involved in the body built, the formation of tissues, organs, etc., in plants, proteins regulate the respiration, photosynthesis, growth, and reproduction. There are some proteins which are specific to the plant or a particular species of plant. Proteomics is a multidisciplinary branch of science that deals with the ...

A. Pandey *, D. Pendarkar, A. D. Patel and S. Agrawal

Institute of Forensic Science, Gujarat Forensic Sciences University, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1518-23

1518-1523

638

235

71.

ANTIOXIDANT MEDIATED ULCER HEALING POTENTIAL OF HYPERIN ISOLATED FROM FLOWERS OF RHODODENDRON ARBOREUM IN EXPERIMENTAL RAT

Hyperin, a flavonoid is an active phytochemical constituent gift in numerous plants as well as, Hypericum perforatum, Drosera rotundifolia, Stachys byzantina, Prunella vulgaris, Rumex acetosella, Abelmoschus manihot and Rhododendron arboreum. It’s protecting result on cultured PC12 cells against toxicity induced by hydrogen peroxide and tert-butyl hydroperoxide. Hyperin, isoquercitrin and querce...

N. Verma *, A. P. Singh and C. V. Rao

J. K. Institute of Technical Excellence, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1524-33

1524-1533

578

188

72.

IN-VITRO ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS OF BARK OF FICUS RACEMOSA LINN. (MORACEAE)

The plant Ficus racemosa L., is a woody large deciduous tree distributed all over India, and grows in the evergreen forest, moist localities, along with the sides of ravines and banks of streams belonging to the family Moraceae, locally know as Attimara and Hindi known as Gular. Ethnobotanically the bark used for anti-diabetic, wounds, useful in asthma and piles recommended in uropathy and treatme...

S. Rajvaidhya * and V. V. Byahatti

Moulana Azad Institute of Pharmacy, Jodhpur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1534-39

1534-1539

605

237