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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 10 (2019) - Issue 12, December

Review Articles

 
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1.

A REVIEW ON QUORUM SENSING INHIBITORS

Antibiotic is the powerful invention of science to damage bacterial infections. But nowadays, the use of careless increasing doses of this antibiotic has led to increasing the resistant power of enemy bacteria. Bacteria are caused by many infectious diseases by proliferation within quorum sensing (QS) mediated biofilms. Quorum sensing can develop microbial pathogenic traits, including biofilm form...

Kaushik Sarkar and Rajesh Kumar Das *

Department of Chemistry, University of North Bengal, Raja Rammohunpur, Darjeeling, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5224-33

5224-5233

191

130

2.

A REVIEW ON ANTIPSYCHOTICS FOR SCHIZOPHRENIA

Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels, and behaves. People with schizophrenia may seem like they have lost touch with reality. Schizophrenia is a split personality disorder which is related to mental illness. Generally, schizophrenia affects approximately 1 percent of all adults’ population. Schizophrenia is different types such as parano...

D. G. Bari *, K. Saravanan and R. Ahmad

Department of Pharmacy, Vivek College of Technical Education, Bijnor, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5234-51

5234-5251

196

94

3.

NANOSTRUCTURED LIPID CARRIER: THE ADVANCED LIPID CARRIERS

The skin is the largest organ of the human body and easily accessible. It’s potential as an alternative route for administering drugs for both systemic and local effects has attracted considerable interest. Most of the topical medications which are applied on the skin or mucous membrane to treat ailments include a wide range of creams, foams, gels, lotions, ointments, eye drops, ear drops, etc. ...

N. Y. Nandvikar, R. R. Lala * and A. S. Shinde

Department of Pharmaceutics Prin. K. M. Kundnani College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5252-65

5252-5265

118

78

4.

DOXORUBICIN AND CHLOROQUINE: A COMBINATION THERAPY TO OVERCOME THE MULTI DRUG RESISTANCE IN CANCER – A REVIEW

Cancer is a genetic disorder that can happen to anybody; anytime. The treatment, where one or more chemotherapeutic agents (anti-cancer drugs) are used either to treat the cancer patients (curative intent with one or combination of anti-cancer drugs) or to prolong the life and to reduce the symptoms in cancer patients is known as Chemotherapy. But nowadays it is observed that when these chemothera...

S. Dey, K. V. V. S. N. Reddy and A. Wadhwani *

Department of Pharmaceutical Biotechnology, JSS Academy of Higher Education and Research -JSS College of Pharmacy, Ooty, The Nilgiri’s Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5266-73

5266-5273

119

68

5.

A REVIEW ON NATURAL GUMS AND THEIR USE AS PHARMACEUTICAL EXCIPIENTS

Recent past has witnessed the promising roles of natural gums as pharmaceutical ingredients. Gums became important excipients in many pharmaceutical preparations owing to their abundance, biodegradability, non-toxicity and comparatively low cost. They have notable applications in pharmaceutical preparation as binders, disintegrants, suspending agents, emulsifiers. The use of these gums as gelling ...

S. Lankalapalli * and D. Sandhala

GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5274-83

5274-5283

125

68

6.

INFLAMMATION: A POTENTIAL SCENARIO ON NOVEL TARGETS AND TARGETED DRUG THERAPY

Inflammation is the vascular event shown by the body against the external material by activating different cells and releasing various chemical mediators to prevent noxious effects. Many drugs like steroidal and non-steroidal drugs are available till the date to treat inflammation but have a number of side effects and centralized on to counteract the COX and LOX pathways. This perspective will use...

P. A. Karale *, M. A. Karale, P. R. Chavan and P. Thaware

School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5284-93

5284-5293

47

33

7.

HYPERHOMOCYSTEINEMIA: A SILENT HASSLE FOR HUMAN BEINGS, ALLIED COMPLICATIONS AND PRAGMATIC STRATEGIES

Hyperhomocysteinemia is a metabolic catastrophe characterized by an elevated level of homocysteine above 15 mmol/L in blood. It is an established risk factor for cardiovascular anomalies. The illness has also crucial impact on other organs and tissues of body. Its morbid effects have been seen during many chronic conditions. It is also considered as a metabolic crunch during gestation as well as g...

J. K. Gupta *, S. Mujwar, K. K. Varshney and M. Varshney

Institute of Pharmaceutical Research, GLA University Mathura, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5294-01

5294-5301

61

31

8.

THE CURRENT TREND IN TREATMENT FOR OSTEOMYELITIS

Osteomyelitis is a very serious disease caused by bacteria, especially Staphylococcus aureus, which directly attacks the bones tissues. Many physicians and surgeons are still looking for the basic cure of the disease. This article mainly focuses on the different kinds of treatments using new drug formulations. Vancomycin coated with chitosan polymers, biodegradable scaffolds, use of major limb amp...

S. Chakraborty *, D. V. Gowda and V. N. Gupta

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Shri Shivarathreeshwara Nagara, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5302-10

5302-5310

45

29

9.

TRENDS OF GREEN CATALYSIS IN SYNTHETIC CHEMISTRY: AN OVERVIEW

This paper is to review the green catalytic synthesis of organic reactions and discussed its advantages over the conventional method of synthesis. Recent advanced technologies have key trend to reduce the negative impacts of chemical environment and helps to obtain sustainability in chemical production. This review tries to bring many catalytic techniques that are safer in nature and more economic...

R. Dubey and J. Pandey *

Amity University, Lucknow Campus, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5311-17

5311-5317

44

26

10.

JUVENILE IDIOPATHIC ARTHRITIS (JIA) IN ADOLESCENTS: A REVOLUTION IN TREATMENT BY AYURVEDA

Introduction: Juvenile idiopathic arthritis (JIA) is chronic inflammatory arthritis in children and adolescents. The symptoms present in JIA are more comparable with features of Aamavata Vyadhi mentioned in Ayurvedic classics. JIA can be treated by Shodhana and Shaman therapy of Ayurveda which is free from any side effects. The main aim of this article is to elaborate on JIA and its treatment by d...

V. Saxena, N. Srivastava * and A. Kumar

Department of Kaumarbhritya / Bal-Roga, Sardar Patel Institute of Ayurvedic Medical Sciences & Research Centre, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5318-26

5318-5326

45

26

Research Articles

 
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Cited
11.

DESIGN, SYNTHESIS, AND EVALUATION OF 1,4-NAPHTHOQUINONE DERIVATIVES AS POTENTIAL EPITHELIAL GROWTH FACTOR RECEPTOR INHIBITORS

In this manuscript, we designed and synthesized 1,4-naphthoquinone derivatives. These derivatives were characterized using the different analytical techniques such as 1H NMR, 13C NMR, FTIR, Mass spectroscopy, melting point, and elemental analysis. The synthesized compounds (MB (1-10)) further subjected to assess the anticancer activity using different cancer cell lines such as MCF-7, HeLa, and Hep...

M. Besan *, M. K. Gautam and A. Jain

Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5327-37

5327-5337

147

93

12.

PHYTOCHEMICAL ASSESSMENT AND METABOLIC FINGERPRINTING OF BOERHAVIA DIFFUSA AND CEPHALANDRA INDICA FROM INDIAN SUB-CONTINENT

The medicinal plants, Boerhavia diffusa and Cephalandra indica are both perennial climbing herbs commonly used in traditional system of medicine for the treatment of several ailments because of their healing properties. The present study aimed to identify the phytochemical constituents of methanolic extracts of these plants, followed by their metabolic fingerprinting, which was carried out by HPTL...

R. Irshad *, S. Ahmed and M. Husain

Department of Biotechnology, Molecular Virology Lab, Jamia Millia Islamia, New Delhi, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5338-46

5338-5346

121

79

13.

ISOLATION AND CHEMICAL CHARACTERIZATION OF POTENTIAL BIOACTIVE COMPOUNDS FROM CASSIA UNIFLORA

Objective: The present study was designed for Isolation of phytoconstituents from pharmacologically potent extracts of leaves of Cassia uniflora based on in-vitro pharmacological screening and their subsequent characterization. Methods: Crude extracts of leaves, stems, and fruits of cassia uniflora were prepared using various solvents such as water, methanol and hydro alcohol. These extracts were ...

S. Jadi *, N. Gorantla, S. Nadendla and S. Dange

Department of Pharmaceutical Chemistry, St. Paul’s College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5347-61

5347-5361

110

68

14.

PREPARATION, CHARACTERIZATION AND EVALUATION OF ANTIFUNGAL ACTIVITY OF CLOTRIMAZOLE NANOSTRUCTURED LIPID CARRIERS

Objectives: The aim of this work was the preparation of Clotrimazole (CM) loaded nanostructured lipid carriers (CM-NLC) and the examination of in-vitro antifungal activity of prepared formula. Methods: High shear hot homogenization method was used for CM-NLC preparation. Different ratios of Compritol AT 888 and Labrasol were used and combined with two types of surfactants: Kolliphor P188 or Kollip...

A. Gardouh, H. Abou-Taleb * and S. Solyman

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt.

DOI: 10.13040/IJPSR.0975-8232.10(12).5362-69

5362-5369

116

59

15.

EFFECTS OF NON-CALORIC ARTIFICIAL SWEETENERS (NAS) ON GLYCAEMIC STATUS IN MALE SWISS ALBINO MICE

Objective: The objective of the study was to estimate the effects of Non-caloric Artificial Sweeteners (NAS) on glycaemic status in male Swiss albino mice. Methods: 36 male Swiss albino mice were selected and divided into six groups of 6 animals each. Group 1 served as control and received a normal pellet diet with drinking water. Groups 2, 3, 4, 5 and 6 received normal pellet diet and drinking wa...

K. Lavanya, R. Arunkumar *, A. Ruckmani, L. Prabhur, V. Meti, K. Neevedha, E. Abinaya and A. N. Nisha

Department of Pharmacology, Chettinad Hospital & Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5370-79

5370-5379

103

52

16.

PREPARATION AND CHARACTERIZATION OF HERBAL NANOFORMULATION CONTAINING ANDROGRAPHIS PANICULATA EXTRACT

This study aimed to investigate the preparation and characterization of polymeric nanoparticles containing extract of Andrographis paniculata using Eudragit S 100 polymer. The methanolic extract of aerial parts of Andrographis paniculata Nees (Acanthaceae) was prepared and standardized for andrographolide content using the High-Performance Liquid chromatography technique. Three formulations contai...

A. U. Devi * and S. Khanam

Department of Pharmacognosy, Moulana College of Pharmacy, Angadippuram, Perinthalmanna, Malappuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5380-85

5380-5385

41

30

17.

IN-VITRO ANTIOXIDANT PROPERTIES OF DELONIX ELATA WHOLE PLANT EXTRACTS

Delonix elata (D. elata) whole plant was chosen to evaluate in-vitro anti-oxidant activities. The total polyphenols and flavonoids were determined after the extraction. DPPH (2, 2'-diphenyl-1-picrylhydrazy), H2O2 (Hydrogen peroxide), NO (Nitric oxide) and TBARS (Thiobarbituric acid) methods were used to evaluate antioxidant activities of D. elata whole plant. The results showed that the highest le...

B. S. S. Bhava, K. Umasankar and A. K. Muthu *

Department of Pharmacy, Faculty of Engineering & Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5386-90

5386-5390

47

24

18.

QSRT STUDIES OF 2-(5-ARYL-1, 3, 4-OXADIAZOL-2-YL)-N-(5-METHYLISOXAZOL-3-YL)-ACETAMIDE DERIVATIVES AS AN ANTIMICROBIAL AGENTS

Quantitative structure relationship techniques (QSRT) is among the most widely used computational technology for analog-based drug design. A molecular modeling approach using theoretical, computational analysis through chem sketch ACD lab online software was done for determination of probable antimicrobial activity. To develop a pharmacophoric model for inhibition, QSRT parameters PCP, ADME, and t...

S. Marri, R. Kakkerla * and M. P. S. M. Krishna

Department of Chemistry, Satavahana University, Karimnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5391-96

5391-5396

66

42

19.

A NEW TARGET FOR DIABETES: HOMOLOGY MODELING AND IDENTIFICATION OF POTENTIAL LEADS THROUGH VIRTUAL SCREENING

Monocarboxylate transporter 11 (MCT11) is a transporter protein encoded by the SLC16A11 gene. MCT11 protein is found to play an important role in many biological activities in different species. MCT11 helps in hepatic lipid metabolism by catalyzing the transport of pyruvate molecules across the membrane. It is also found to be involved in regulation of Diabetes. Therefore, MCT11 protein is taken i...

K. N. Kumar *, N. V. Sreedevi and P. Spandana

Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Medicinal Chemistry, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5397-03

5397-5403

65

28

20.

ALTERATIONS IN LIPID PROFILE PARAMETERS OF ALBINO RAT AFTER INTOXICATION OF MERCURY SELENIDE NANOPARTICLES

Nanoparticles are of great scientific interest, in fact, a bridge between bulk materials and atomic or molecular structures. The main characteristic of nanoparticles is their extreme smaller size, which falls in the transitional zone between molecules and the corresponding bulk materials. Lipids and fatty acids are a family of molecules classified within the lipid macronutrient class. The present ...

K. Kumar * and P. N. Saxena

Department of Zoology, Toxicology Lab, School of Life Sciences, Khandari Campus, Dr. B. R. Ambedkar University, Agra, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5404-09

5404-5409

41

28

21.

PRECLUSION OF HYPOXIA: IDENTIFICATION OF POTENTIAL INHIBITOR AGAINST HIF-1 ALPHA PROTEIN THROUGH MOLECULAR DOCKING

Low level of oxygen in tissues leads to hypoxia, and hypoxia-inducible factors (HIF) regulate the hypoxic and normoxic conditions in various tissues. During normoxia, HIF-1α binds to von Hippel-Lindau E3 ubiquitin ligase complex that targets HIF-1α to the ubiquitin-proteasome pathway for proteolytic destruction. But in hypoxia, HIF-1α move to the nucleus where it binds to CBP/p300 at CH1 domain...

P. Gupta, V. K. Jatav and S. Sharma *

Department of Biotechnology, MITS, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5410-15

5410-5415

43

24

22.

PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF AERIAL PART EXTRACTS OF CYCLEA PELTATA

In recent years, there is an increasing interest in finding antioxidant phytochemicals for the prevention and treatment of complex diseases like diabetes, cancer, and atherosclerosis, which are associated with excessive biological oxidative stress. Plants are rich source of natural antioxidants that inhibit the propagation of free radical reactions and protect the human body from degenerative dise...

S. Jagadeepchandra, K. Mruthunjaya * and N. Lakshmidevi

Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5416-22

5416-5422

48

25

23.

HPLC ANALYSIS OF FLAVONOIDS FROM PROPOLIS OF DIFFERENT HONEYBEE SPECIES IN SELECTED LOCATIONS OF BANGALORE

Propolis is a natural resinous substance with a wide range of biological properties, synthesized by bees from bud exudates of some plants. Bees make use of propolis as a building material and to defend the hive. The chemical composition of propolis varies depending on vegetation and species having plethora of therapeutic activities. To detect compounds present in propolis an efficient, precise, an...

A. Shashikala *, B. P. Harini and M. S. Reddy

Department of Zoology, Maharani Lakshmi Ammanni Colege for Women, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5423-29

5423-5429

42

21

24.

DESIGN AND IN-VITRO EVALUATION OF TENOXICAM NANOGEL CONTAINING NOVEON POLYMER

The aim of present work is to design a Tenoxicam loaded nanogel for the anti-inflammatory and analgesic effect of prepared nanogel. Tenoxicam is one of the NSAIDs of oxicam class; it is very potent and useful for chronic use in rheumatoid arthritis and osteriostatis. The formulations of nanogel based materials have high drug loading capacity, biocompatibility, and biodegradability which are the ke...

S. S. Chopade

Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Panhala, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5430-34

5430-5434

48

25

25.

FORMULATION EVALUATION AND OPTIMIZATION OF METFORMIN HCl MATRIX TABLET USING NATURAL POLYMER

Objectives: The main objective was to find out a suitable and effective natural release retardant, which can be used in matrix tablet preparation along with synthetic excipients. Methods: Tamarind seed polysaccharides (TSP) were isolated from Tamarindus indica by hot extraction method followed by freeze-drying and yield was found to be 16.85%. Microbial studies confirmed that TSP doesn’t support...

T. Saikia

Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5435-42

5435-5442

48

26

26.

SIMULTANEOUS ESTIMATION OF AMANTADINE HYDROCHLORIDE AND OSELTAMIVIR PHOSPHATE USING PRECOLUMN DERIVATIZATION TECHNIQUE

A simple, efficient HPLC method has been developed and validated for simultaneous determination of Amantadine hydrochloride and Oseltamivir phosphate using pre-column derivatization with phenyl isothiocyanate (PITC). The chromatography separation was achieved on Phenomenex C18 column of 250 × 4.6 mm 5 µm particle size, mobile phase used for chromatographic run consisted of acetonitrile and water...

V. Ramya, Zaranappa * and Y. N. M. Gowda

Department of Pharmaceutical Chemistry, Government College of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5443-49

5443-5449

43

28

27.

FORMULATION AND EVALUATION OF HYDROTROPIC SOLID DISPERSION OF ELUXADOLINE

In the present research, newly developed hydrotropic solid dispersion technique utilizing the use of aqueous solvent was developed, to avoid the utilization of organic solvent and all together declining their toxicity. This technology was employ intended for preparing the dispersion of Eluxadoline by using new hydrotropic agent sodium caprylate with using different ratio. Prepared formulations wer...

M. Dhere *, A. Majumdar and N. Malviya

Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5450-54

5450-5454

44

25

28.

FORMULATION AND EVALUATION OF ANTIDIABETIC CAPSULES OF KAEMPFEROL-3-O-Β-D-6”-(P-COUMAROYL) GLUCOPYRANOSIDE EXTRACTED FROM ALLIUM CEPA L.

Allium cepa L. has known potent antidiabetic effects due to several of its constituents, including kaempferol -3-O-β-D-6''-(p-coumaroyl) glucopyranoside (kaempferol). This preliminary work was aimed at preparing oral hard gelatin capsules of kaempferol obtained from Allium cepa L. In order to obtain more potent hypoglycemic activities, lower side effects with good patient compliance over the crud...

J. I. Ogbonna *, O.N.C. Umeh, C. C. Mbah, B. C. Amadi, S. I. Ofoefule and B. C. Ozumba

Drug Delivery and Nanotechnology Research Unit (RUNDD), Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Enugu State, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.10(12).5455-62

5455-5462

55

47

29.

ESTIMATION OF SOLID DOSAGE FORMS OF COMBINED ANTIHYPERLIPIDAEMIC DRUGS BY VALIDATED REVERSE PHASE LIQUID CHROMATOGRAPHIC METHOD

A reverse-phase high-performance liquid chromate-graphic method (RP-HPLC) was developed for the simultaneous estimation of combined dosage form of ezetimibe with simvastatin and rosuvastatin using RP-C18 column. For estimation of ezetimibe and simvastatin, the mobile phase (acetonitrile: water and pH adjusted to 4.5 with acetic acid) was pumped at a flow rate of 0.8 ml/min in the ratio of 85:15% v...

G. K. Dyade *, R. L. Sawant and R. B. Jadhav

SVPM College of Pharmacy, Malegaon (BKII) Baramati Savitribai Phule Pune University, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5463-70

5463-5470

44

27

30.

FABRICATION OF TWEEN 80 LIGAND COATED CHOLESTEROL-SOYA LECITHIN BILAYERED NANOLIPOSOMES FOR IMPROVED RELEASE OF MEROPENEM AGAINST ARTIFICIAL BLOOD BRAIN BARRIER

The blood-brain barrier is the most challenging physiological obstacle for drug moieties for reaching the central nervous system. Meropenem is a drug used against meningitis, however crossing BBB is also a challenging realm of problem for the same. Therefore attempt has been undertaken to strategically design Meropenem loaded cholesterol-soya lecithin nanoliposomes (MCSLN). MCSLN was prepared by n...

A. Ghosh, S. Nandi, A. Roy, S. Singh, S. Singhmura and S. Basak *

Dr. B. C. Roy College of Pharmacy & Allied Health Sciences, Durgapur, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5471-80

5471-5480

53

34

31.

APPLICATION OF STABILITY INDICATING UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CAFFEINE IN GEL FORMULATION, PLASMA AND URINE

A simple, sensitive and stability indicating UV spectrophotometric method was developed and validated for the estimation of caffeine in a gel formulation, plasma and urine samples using acidified alcohol as solvent. At absorbance maxima of 265 nm, the linearity was found to be in range of 4-20 µg/ml with correlation coefficient 0.9988. The method was applied for estimation of caffeine in a gel fo...

T. H. Kumar *, P. Mounika, S. S. Likhitha, S. Aswini, T. Kavya, T. Sudandhini and A. V. Sree

Vignan Institute of Pharmaceutical Technology, Duvvada, Vishakapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5481-88

5481-5488

55

22

32.

EVALUATION OF NOVEL LIGAND FOR THE MAINTENANCE OF NATIVE Aβ(1-42) PEPTIDE CONFORMATION: RELEVANCE TO ALZHEIMER’S DISEASE

Alzheimer's disease (AD) is a disorder of the central nervous system with progressive neurodegeneration, cognition, and memory loss. A major molecular hallmark of the disorder includes extracellular deposition of the Amyloid beta-peptide (Aβ) in senile plaques, the appearance of intracellular neurofibrillary tangles. The Aβ peptide is produced by sequential cleavage of the Amyloid precursor prot...

D. A. Mir and R. B. Rathanam *

Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5489-98

5489-5498

45

23

33.

OPTIMIZATION OF PLURONIC LECITHIN ORGANOGEL OF TERBINAFINE HYDROCHLORIDE USING DESIGN OF EXPERIMENTS FOR THE TREATMENT OF FUNGAL DISEASES

The research work focused on the optimization of Terbinafine HCl (TBH) pluronic lecithin organogels (PLOs) for increasing the penetration and efficacy of the drug. The factors affecting the PLOs such as viscosity and percentage drug release, were screened and optimized using the Box-Behnken design. The optimum formulation based on desirability (0.995) exhibited 3139.92 Cp for viscosity and 93.4561...

S. Saha, B. K. R. Sanapalli and V. V. S. R. Karri *

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5499-09

5499-5509

41

23

34.

SYNTHESIS AND BROAD SPECTRUM ANTIBACTERIAL ACTIVITIES OF 2-PYRAZOLINES SYNTHESIZED FROM CHALCONES

2-Pyrazolines are well known, and important nitrogen-containing five-membered heterocyclic compounds which belong to the family of azoles and have been found to possess considerable activities, like anticancer, antibacterial, antifungal, immunosuppressant and antiamoebic activity. In the present work, ten novel pyrazolines were prepared from chalcones, characterized and evaluated for their antibac...

B. Vinod * and V. V. Prasanth

St. Joseph’s College of Pharmacy, Cherthala, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5510-16

5510-5516

41

28

35.

EFFECT OF PHYSICAL MODIFICATION ON DISSOLUTION OF NABUMETONE: A BCS CLASS II DRUG

Objective: Physically modified forms of BCS class II drug Nabumetone (NBT) was studied for dissolution in water and pharmacopoeial dissolution media (2%w/v sodium lauryl sulfate in water). Characterization was to identify the suitability of physical processing like heating, cooling, grinding, and milling operations anticipated during commercial manufacturing of dosage forms. Materials and Methods:...

J. Joseph * and J. Harindran

Department of Pharmaceutical Sciences, Centre for Professional and Advanced Studies, Cheruvandoor Campus, Ettumanoor, Kottayam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5517-23

5517-5523

45

22

36.

DESIGN, SYNTHESIS, DOCKING STUDIES AND BIOLOGICAL EVALUATION OF NOVEL HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES AS HISTONE DECAETYLASE INHIBITORS

A new series of hydroxamic (5a-5j) and carboxylic acid analogs (4a-4j) based on the 1, 3, 4-thiadiazole scaffold was designed and synthesized to explore its potential as new antitumor agents. The chemical structures of the compounds were confirmed based on TLC, IR, 1H NMR, and 13C NMR analysis. Molecular docking studies showed that the target compounds correctly dock into the binding pocket of his...

B. K. Gharia *, B. N. Suhagia, J. R. Upadhyay and P. S. Sidat

Department of Pharmaceutical Chemistry, Maliba Pharmacy College, Uka Tarsadia University, Bardoli, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5524-36

5524-5536

43

26

37.

DFT INVESTIGATION OF GEOMETRICAL STRUCTURE, IR AND RAMAN SPECTRA OF VINYL HALIDES CH2=CH–X (X IS F, Cl AND Br)

The geometrical structure and conformational energy stability of vinyl halides CH2=CH–X (X = F, Cl, and Br) were examined by using Density Functional Theory calculations (B3LYP method in combination with 6-311G* basis sets). The values of HOMO-LUMO gap (DE) for vinyl halides (fluoride, chloride and bromide) were 7.68 (eV), 7.10 (eV) and 6.55 (eV) respectively. The calculated geometrical paramete...

T. A. Yousef, R. K. Hussein * and M. Abou-krisha

Department of Physics, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, KSA.

DOI: 10.13040/IJPSR.0975-8232.10(12).5537-44

5537-5544

45

27

38.

STUDY OF MANGIFERIN ISOLATED FROM LEAVES OF MANGIFERA INDICA ON MYELOID LEUKEMIA ALONG WITH DIFFERENT HUMAN CANCER CELL LINES

In different myeloid leukemia cases resistance to diverse treatment regimen owes to multiple molecular mechanisms of cellular network. Epigenetic dysregulation, gene mutations, overexpression of multidrug resistance genes, abnormal immune function, the presence of chemotherapy-resistant leukemia-initiating cells, and aberrant signaling pathways could be the lead cause of this kind of aberration. S...

H. K. Manikyam

Faculty of Science, Department of Chemistry, North East Frontier Technical University, Aalo, Arunachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5545-52

5545-5552

60

19

39.

STUDY OF EFFECT OF METFORMIN ON LIPID PROFILE IN TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE TEACHING HOSPITAL

Type 2 diabetes mellitus poses an important health care problem because of its associated two to threefold increased risk of cardiovascular disease and its high prevalence and incidence worldwide. Dyslipidemia is an independent risk factor for severe morbidity and mortality in terms of cardiovascular risk in type-2 DM patients. Studies have shown an association between metformin and lipid profile ...

C. R. Patel, D. A. Patel * and D. J. Patel

Department of Pharmacology, Government Medical College, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5553-58

5553-5558

125

28

40.

ETHNOGYNAECOLOGICAL DISORDERS OF MEDICINAL PLANTS USED BY TRIBAL PEOPLE IN GEDAMALAI, NAMAKKAL DISTRICT, SOUTHERN EASTERN GHATS, TAMIL NADU

The present exploration is an attempt to an ethnobotanical study was conducted in Eastern Ghats of Tamil Nadu, for the investigation of a medicinal plant used to treat several diseases by the local health healers by Gedamalai Tribes, Namakkal District. Data were collected during March 2015-January 2016. Quantitative analysis, including the informant consensus factor and use-value was performed to ...

R. Rajeswari and S. Murugesh *

Department of Botany, School of Life Sciences, Periyar University, Salem, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5559-64

5559-5564

52

22

41.

SCREENING OF TERATOGENICITY OF THE MARINE ALGA SYMPHYOCLADIA LATIUSCULA

Objective: To explore the Teratogenicity of isolated Polyphenols of Symphyocladia latiuscula (PSL) on pregnant female rats. Experimental Design: The marine alga Symphyocladia latiuscula were the preparation of methanolic extract followed by isolation of Polyphenols. The Teratogenic study was performed according to the OECD guidelines, no 415. And the test drug; PSL 100, 200 and 1000 mg/kg and posi...

A. Sharma *, R. Koneri and D. K. Jha

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5565-72

5565-5572

44

18

42.

THE HEATH RELATED QUALITY OF LIFE (HRQOL) FOR HYPERTENSIVE PATIENTS IN EASTERN PROVINCE IN SAUDI ARABIA: CROSS SECTIONAL STUDY

Background: Hypertension is associated with the flow of blood under high pressures, and is a risk factor for coronary heart disease. Methodology: We designed a prospective observational study that included 280 participants to investigate the effect of hypertension on the health-related quality of life (HRQOL) for hypertensive patients in the eastern province of KSA. To measure HRQOL, this study us...

D. M. Alshayban, N. M. Alajmi, L. Y. Almarzooq, W. N. Altamimi, R. Joseph and F. H. Pottoo *

Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.10(12).5573-78

5573-5578

65

21

43.

DEVELOPMENT AND EVALUATION OF CANDESARTAN CILEXETIL TABLETS USING CRYSTAL AGGREGATES PREPARED BY POLYMER ENRICHED BRIDGING LIQUID

The main objective of the study was to formulate tablets of Candesartan cilexetil using the crystal agglomerates for the enhancement in flow properties and solubility. The crystal agglomerates were prepared by polymer enriched bridging liquid (PEBL) technique. The process requires three solvent systems, the good solvent for the drug, the bad solvent and the bridging liquid. The hydrophilic polymer...

K. Manoj, P. Seenivasan *, K. Arul and M. S. Kumar

Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5579-86

5579-5586

46

25

44.

SCREENING FOR PHYTOCHEMICAL, FLAVONOID CONTENT, ANTIOXIDANT AND ANTHELMINTIC POTENTIAL OF SIDA SPINOSA

Background: Sida spinosa (Family: Malvaceae) is a well-known herb, has considerable medicinal significance in the tribal region of Chhattisgarh. Several ethnomedicinal survey reports have been revealed its potential to cure ailments such as skin diseases, diarrhea, gonorrhea, and asthma. Objective: The aim of the present study to screen phytochemical, flavonoid content, antioxidant and anthelminti...

R. Tirkey

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5587-91

5587-5591

49

22

45.

CHARACTERIZATION OF LIGNINOLYTIC ENZYMES AND DECOLOURIZATION OF SELECTED TEXTILE DYES FROM THE BLUSHING BRACKET MUSHROOM, DAEDALEOPSIS CONFRAGOSA

The effect of a wide range of culture conditions on the production of laccase (Lac), Lignin peroxidase (Lip) and Manganese peroxidases (MnP) by Daedaleopsis confragosa was studied. A ligninolytic enzyme-producing bracket mushroom, Daedaleopsis confragosa was isolated from tree trunk from Karwar coastal region, Karnataka, India and subjected to production and dye decolorization study. Ligninolytic ...

S. I. Manawadi *, A. B. Vantamuri and S. K. Guruvin

Department of Biotechnology, Government Arts and Science College, Karwar, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5592-98

5592-5598

42

21

46.

NANOTECHNOLOGY BASED ORAL FORMULATIONS OF TOLBUTAMIDE BY USING BIODEGRADABLE POLYMER

The present study concerns the development, characterization, and optimization of nanoparticulate oral formulations of Tolbutamide using poly (ԑ-caprolactone) which is a biodegradable polymer. Emulsion Solvent Evaporation technique was used for preparation of drug-loaded polymeric nanoparticles. This research was carried out to improve the therapeutic efficacy of tolbutamide by increasing its bio...

N. Singh, P. K. Verma * and S. Nanda

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5599-05

5599-5605

44

21

47.

AN INVESTIGATION OF THE DNA BINDING PROPERTIES OF Mn2+, Co2+ AND Ni2+ COMPLEXES WITH 2-AMINOBENZONITRILE AND OCTANOATE ION AS LIGANDS

Three novel metal complexes of 2-aminobenzonitrile (ABN) and octanoate ion (OC) with Mn2+, Co2+, and Ni2+ have been prepared by using microwave irradiation. The DNA-binding properties of the free ligand 2-aminobenzonitrile and its Mn2+, Co2+ and Ni2+ complexes have been investigated by fluorescence measurements. The results suggest that ABN, Mn2+, Co2+  and Ni2+ complexes both bind to DNA via an...

N. Muruganantham *, R. Govindharaju and P. Anitha

PG & Research Department of Chemistry, Thanthai Hans Roever College (Autonomous), Perambalur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5606-11

5606-5611

39

21

48.

PREPARATION, STANDARDIZATION AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ARKA LAVANA

The liver is a vital organ of the human body. It is responsible for protecting the body from harmful substances and the maintenance of good health. In last few years, various types of liver disorders, such as drug-induced liver disease, hepatomegaly, fatty liver disease, liver cirrhosis, autoimmune hepatitis, chronic viral hepatitis, autoimmune hepatitis, etc. are become a people’s health proble...

J. Singh, A. K. Singh, A. K. Kushwaha, D. N. S. Gautam and M. K. Nandi *

Department of Medicinal Chemistry, Faculty of Ayurveda, IMS, BHU, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5612-21

5612-5621

42

18

49.

ANGIOTENSIN CONVERTING ENZYME INHIBITION: A MODIFYING PLAYER ON ATHEROGENESIS IN HEMODIALYSIS PATIENTS WITH HEPATITIS C INFECTION

Background and Aim: This study aimed to investigate certain non-traditional risk factors for atherosclerosis in CKD hemodialysis patients with and without HCV infection. Methods: The eligible hemodialysis patients attending our renal dialysis unit were subjected to demographic assessment, testing for HCV infection, basic biochemical profile, and assaying for serum insulin levels, angiotensin conve...

R. H. M. El-deen *, M. M. A. Khalifa, A. M. Taye and M. M. Khattab

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, Egypt.

DOI: 10.13040/IJPSR.0975-8232.10(12).5622-31

5622-5631

52

26

50.

ISOLATION, IDENTIFICATION AND QUANTIFICATION OF BIOACTIVE COMPOUNDS FROM AMARANTHUS HYPOCHONDRIACUS LEAF EXTRACT: A VITAL SOURCE OF POTENT NATURAL ANTIOXIDANTS

In this study we aimed at isolation, identification, and quantification of two phenolic compounds reported for the first time in leaves of Amaranthus hypochondriacus. A non targeted GC-MS metabolite profiling of hexane extracts of amaranth leaves was done which indicated the presence of major phenolic compounds. Two alkylated phenols namely 2,4-di-tert-butyl phenol (A) and 3-(3,5-di-tert-butyl-4-h...

A. G. Agarwal, M. I. Khan *, K. Singh and O. P. Sidhu

Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5632-38

5632-5638

42

27

51.

SYNTHESIS AND CHARACTERIZATION OF NOBLE ANTICANCER DRUG OF CHITOSAN-5FU CONJUGATED FORMULATION

Cancer is one of the emergings, and best-understood neoplasm’s from a genetic perspective, yet it remains the second most common cause of cancer-related death, indicating that some of its cancer cells are not removing completely by current therapies. Chitosan is a polysaccharide β-linked D-glucosamine and N-acetyl-D-glucosamine were used as conjugate to 5Fluorouracil. 5FU is one of the most com...

V. Surendra *, T. Haribabu, U. R. Sharma and P. M. Manjunatha

Acharya & B. M. Reddy College of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5639-43

5639-5643

53

21

52.

DEVELOPMENT AND VALIDATION OF UPLC METHOD FOR ESTIMATION OF % RELEASE OF SOME ANTI-HIV DRUGS IN FIXED DOSE COMBINATION

A simple, accurate and precise UPLC method was developed and validated for dissolution testing of Lamivudine, Tenofovir disoproxil fumarate and Efavirenz in tablet dosage form. The separation was achieved under optimized chromatographic condition on an Acquity UPLC BEH (50 mm × 2.1 mm, 1.7 μm) column with mobile phase consist of 20 mM potassium dihydrogen phosphate buffer pH 2.5: acetonitrile wi...

P. Patel *, S. Patel and J. Sadiwala

Parul University, Department of Quality Assurance, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5644-49

5644-5649

44

26

53.

ESTIMATION, RECOVERY STUDY & ASSAY OF MARKETED DOSAGE FORM OF BUPROPION HYDROCHLORIDE THROUGH DERIVATIVE SPECTROSCOPIC METHOD

Depression is the most common and spreadable disorder in recent age as people are going through a lot of pressure in their daily work caliber and so many unconditional events. A new approach called derivatization spectroscopy was developed for the anti-depressant agent, marketed formulation of Bupropion hydrochloride, to confirm the interfering substances from the excipients of solid dosage form, ...

S. Maji and M. R. Jeyaprakash *

Department of Pharmaceutical Analysis, JSS College of Pharmacy JSS Academy of Higher Education and Research, Ooty, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5650-56

5650-5656

166

41

54.

A NATURAL COUMESTAN WEDELOLACTONE TARGETS INFLAMMATORY CYTOKINES TO INITIATE APOPTOSIS IN HUMAN CERVICAL CANCER CELLS

Objective: Wedelolactone is a naturally (WDL) occurring coumestan of phytoestrogen category that possess anticancer and anti-inflammatory property. In this study, the anti-inflammatory effect of WDL on human cervical cancer cells (HeLa) and initiation of apoptosis mechanism were investigated. Methods: MTT assay and Trypan blue assay were demonstrated to detect the inhibitory effects of WDL on cell...

R. G. J. Christobel, S. S. Jaganathan, M. P. Abirami, P. Rasappan and S. Shila *

Department of Biochemistry, VRR Institute of Biomedical Science (Affiliated to University of Madras), Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5657-63

5657-5663

29

16

55.

DEVELOPMENT AND EVALUATION OF MEDICATED BIODEGRADABLE FILM FOR WOUNDS AND BURNS

As a part of our ongoing effect to develop a biodegradable medicated film for wound healing using chitosan and HPMC as polymers. The drug used is Silver sulfadiazine. This formulation produces better biodegradability and bioadhesion. The biodegradable film is non-toxic and non-irritant to the skin. An animal wound model was performed on the back of the rats and treated, respectively with medicated...

U. P. Anuroop *, S. S. Nair and A. J. Chacko

Westfort College of Pharmacy, Thrissur, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5664-72

5664-5672

86

24

56.

GRADIENT HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF RELATED SUBSTANCES IN [(3aS, 4R, 6aR)-2, 3, 3a, 4, 5, 6a-HEXAHYDROFURO [2, 3-b] FURAN-4-YL] N-[(2S, 3R)-4-[(4-AMINOPHENYL) SULFONYL-(2-METHYLPROPYL) AMINO]-3-HYDROXY-1-PHENYLBUTAN-2YL] CARBAMATE DOSAGE FORM

A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for quantification of Darunavir in bulk and its tablet dosage form. The separation was carried out on Zorbax Eclipse XDB C18 (150 × 4.6 mm; 5 µm) column at 35 °C temperature using ammonium acetate buffer as mobile phase-A, acetonitrile (100%) as mobile phase-B. The flow rate was 1.0 ml/min and effluent ...

B. K. Kumar *, V. G. Sekaranand and K. B. C. Shekar

Department of Pharmaceutical Analysis, Sri Venkateswra College of Pharamacy, Chittoor, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5673-82

5673-5682

29

16

57.

ASSESSMENT OF OXIDATIVE STRESS MARKERS IN CATARACT

Introduction: In spite of the progress made in surgical techniques for cataract removal all over the world during last ten years; still age related cataract remains the leading cause of visual impairment. The etiology of cataract is multi-factorial and oxidative damage is one of the causes. Aim: To estimate oxidative stress by markers like enzymatic antioxidant Superoxide Dismutase (SOD) and lipid...

V. S. Pawar *, A. V. Sontakke and S. K. Pawar

Department of Biochemistry, MBBS, MD Biochemistry, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5683-88

5683-5688

26

14

58.

ANTIMICROBIAL SCREENING AND ANTI-ULCEROGENIC EFFECTS OF LEPIDIUM SATIVUM EXTRACT ON H. PYLORI INDUCED GASTRIC ULCER IN A RAT MODEL

Purpose: Helicobacter pylori (H-pylori) infection has been commonly associated with gastric ulcers. Lepidium sativum (L. Sativum) is an herbaceous edible plant, botanically related to mustard and watercress with remarkable pharmacological features. In this study, we investigate the anti-microbial and anti-oxidant effect of L. sativum seed methanolic extract in-vitro and correlate this with the gas...

N. A. Salem *, G. S. Ibrahim and M. I. Al-Khalaf

Department of Biochemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.10(12).5689-99

5689-5699

29

15

59.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NEW HETEROCYCLIC DERIVATIVES OF CHALCONE AS ANTIHYPERGLYCEMIC AGENTS

Protein tyrosine phosphatase 1B (PTP1B) is an important target for diabetes since inhibition of PTP1B offers therapeutic benefits in insulin-resistant diabetes. Considering this fact in present investigation various heterocyclic derivatives of chalcone were synthesized and evaluated for their PTP1B inhibitory activity as antihyperglycemic agents. Heterocyclic derivatives; isoxazoline (II A-II E), ...

A. Jain * and D. K. Jain

IPS Academy College of Pharmacy, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5700-06

5700-5706

23

14

60.

DEVELOPMENT AND EVALUATION OF HP-β-CD COMPLEXATION BASED NOVEL OPHTHALMIC GEL FORMULATION OF NEPAFENAC

Nepafenac is an analgesic and anti-inflammatory drug, used in post-operative ocular pain and presently available in the market in the form of 0.1% ophthalmic suspension eye drop due to aqueous insolubility of the drug. The present formulation is not only poor patient compliant due to suspension form but also suffers from a short corneal residence and inadequate ocular bioavailability. The objectiv...

P. K. Soni * and T. R. Saini

Department of Pharmacy, Shri G. S. Institute of Technology and Science, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(12).5707-14

5707-5714

28

18