Volume 10 (2019) - Issue 3, March
CUBIC LIQUID CRYSTALLINE NANOPARTICLES (CUBOSOMES): A NOVEL CARRIER FOR DRUG DELIVERY
Lyotropic liquid crystalline systems, such as reversed bicontinuous cubic phases acquire progressive attention because of their unique microstructure and physicochemical properties. Cubosomes were nanostructured liquid crystalline particles, formed from a certain group amphiphilic lipids in definite proportions in water and was stabilized with a triblock copolymer. Substances in use were biocompat...
A CRITICAL REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEMS FOR MANAGEMENT OF INFLAMMATORY BOWEL DISEASE
Inflammatory bowel disease (IBD) refers to the inflammation of the colon and small intestine of the body, in which Crohn's disease and ulcerative colitis are the principal types of IBD. This article covers most of the information related to a drug delivery system for treatment regarding intestinal diseases more emphasized to inflammatory bowel diseases. Currently, using delivery systems for target...
ALZHEIMER’S DISEASE: A COMPREHENSIVE REVIEW
Alzheimer disease (AD) is the most common cause of dementia which affects more than 44 million individuals worldwide. It has been noticed that there is only symptomatic treatments are available to treat AD, but no cure exists. It is a neurodegenerative disease characterized by Alois Alzheimer’s in 1906, and neuro-degenerative diseases are one of the major concerns facing by the modern health car...
PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE OF BACOPA MONNIERI – AN ETHNOMEDICINAL PLANT
In recent times, the use of herbal products has increased tremendously in the developing as well as in developed countries. Bacopa monnieri is one of the most important medicinal plant that has been consumed for thousands of year as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative and anti-epileptic agent. For many years, a lot of commercial and medicinal researches have bee...
PHARMACOLOGICAL POTENTIAL OF GREEN ALGAE CAULERPA: A REVIEW
From the beginning of civilization, humans depend on the natural products for their food and as medical treatment. Diversity in various bioactive compounds from marine organisms has been tested for the multiple pharmacological effects. Marine algae are surviving in a competitive environment with developed defense strategies and significant levels of chemical structural diversity with a wide variet...
HYDROTROPHY: NOVEL SOLUBILITY ENHANCEMENT TECHNIQUE: A REVIEW
Drug discovery and development plays a major role in the world and serves mankind. The major criteria to be considered and given importance in drug development is the solubility of a drug. Among all newly discovered chemical entities, about 40% of drugs fail to reach the market due to their poor aqueous solubility or lipophilicity. Poor solubility is not only a problem for formulation development ...
DIABETIC RETINOPATHY: AN OVERVIEW
Diabetes mellitus is a merge of assorted disorders commonly arise with happening of hyperglycemia and glucose intolerance due to which there be a lack of insulin production will occur. The two major classes of diabetes mellitus are type 1 diabetes mellitus and type 2 diabetes mellitus. For the prevention and controlling the increase of glucose, medical science uses a large array of pharmaceutical ...
DISPERSIBLE FORMULATION MAKEUPS FOR PEDIATRIC USE: A REVIEW
Childhood is characterized by periods of rapid growth, maturation, and development. There is a change in the magnitude of the dose required during childhood and adolescence. Thus, Paediatric practice requires a range of dosage forms that are acceptable at different ages and abilities and a range of strengths or concentrations allowing administration of the correct age-related dose. Literature show...
AN IDENTIFICATION OF CROP DISEASE USING IMAGE SEGMENTATION
Agriculture forms a vital part of India’s economy. More than 50% of India’s population is dependent on agriculture for their livelihood. In India, many crops are cultivated, out of which wheat is one of the most important food grains that this country cultivates and exports. Thus it can be seen that wheat forms a major part of the Indian agricultural system and India’s economy. Hence, the ma...
A REVIEW ON THE PHARMACOGNOSTICAL, ECOLOGY AND PHARMACOLOGICAL STUDIES ON MARINE RED ALGAE – HYPNEA VALENTIAE
Seaweeds are the potential marine living resources in the world. More than 20,000 seaweeds are distributed throughout the world, of which only 221 (1.1%) are commercially utilized, which includes 145 species for food and 110 species for phycocolloid production. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active...
POLYCYSTIC OVARIAN SYNDROME- A MULTIFACETED DISEASE: A REVIEW
Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine disorders in females of reproductive age. Globally, it has been found that PCOS affects 10% of reproductive-age women when using the NIH criteria for diagnosis, and up to 18% of reproductive-age women are diagnosed with PCOS as per the Rotterdam criteria. Mostly symptoms of PCOS include irregular menstrual cycles, signs of h...
COLON SPECIFIC DRUG DELIVERY SYSTEM: AN APPROACH TO TARGET COLONIC DISEASES
Drug as such, may not show the desired therapeutic effect; drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiasis, colonic cancer, local treatment of co...
PROTECTION OF MEDICINAL PLANTS: A LEGAL PERSPECTIVE IN THE STATE OF JAMMU & KASHMIR
The indigenous and traditional health care system based on the rich diversity of plants associated knowledge serves more than 70% of the Indian population. More than 7500 species of plants have been used in Indian medical traditions and over 2700 documented species of plants are used in classical medical systems of Ayurveda, Unani and Siddha. About 1800 plants are documented in various Ayurvedic t...
QUALITY BY DESIGN: THE TOOL FOR REGULATORY COMPLIANCE
QbD decrees the definition of a goal for the method and accentuates thorough evaluation and scouting of alternative methods systematically to obtain ideal method performance. QbD tools like risk assessment and design of the experiment, empowers better quality to be instilled into the analytical method and facilitate prior understanding and identification of variables affecting the method performan...
FLAXSEED OIL AMELIORATES METHOTREXATE-INDUCED OXIDATIVE STRESS AND HEPTO-RENAL TOXICITY IN MALE RATS
This study aimed to investigate the protective effect of flaxseed oil against hepato-renal toxicity induced by methotrexate. Rats treated with methotrexate exhibited elevations in the levels of AST, ALT, ALP, γGT, LDH, urea, creatinine, uric acid, and bilirubin. Furthermore, the levels of MDA, NO and the relative ratio of the gene expression of COX-2 and iNOS were significantly increased, accompa...
MODULATION OF mTOR RECEPTOR IN DIABETIC NEPHROPATHY BY SANTALIN A OF LAL CHANDAN (PTEROCARPUS SANTALINUS): AN IN-SILICO ASSESSMENT BY MOLECULAR DOCKING
Background: Diabetic nephropathy (DN) is a primary cause of end-stage renal disease globally. Activation of mTOR and reduced autophagy has been identified as one of the pathogenic pathways. The presently available drugs have been successful in inhibiting the mTOR signaling, but show low oral bioavailability and suboptimal solubility. Rapamycin is a selective inhibitor of mTOR, shown significant pr...
EFFECT OF PROBIOTIC LACTOBACILLUS FERMENTUM MCC3216 ON PROGRESSION OF TYPE 2 DIABETES WITH THEIR ANTI-INFLAMMATORY ACTIVITY IN HIGH FRUCTOSE FED DIABETIC RATS
The antidiabetic and anti-inflammatory effects of probiotic Lactobacillus fermentum MCC3216 was investigated in high fructose-fed type 2 diabetic rats. Type 2 diabetes was induced by feeding high fructose diet to male albino Wistar rats. A single daily dose of 2 × 108 CFU/ml of L. fermentum MCC3216 was given to Wistar rats for 8 weeks. The fasting blood glucose, body weight, oral glucose toleranc...
INDUCED COAGULATION AS A COMPLICATION OF INFLAMMATORY REACTIONS IN MICE TREATED WITH MONOSODIUM GLUTAMATE
Monosodium glutamate (MSG) is a familiar food additive processed to enhance the taste. This work was carried out to investigate the effect of MSG on platelets profile and indices of thrombus formation together with the detection of some plasma inflammatory markers. The study used adult male mice divided into five groups: a control group and four groups treated with different doses of MSG (2, 4, 8 ...
ROSMARINIC ACID LOADED CHITOSAN NANOPARTICLES FOR WOUND HEALING IN RATS
Drug release properties from dosage forms can be modified by using many rate controlling polymers. Such controlled release properties from carrier systems are desirable since efficient drug delivery is achieved. The aim of the present study was to develop efficient chitosan nanoparticles loaded with rosmarinic acid (RA) and evaluate its drug release properties and wound healing efficiency in rats....
DISCOVERY OF NEW ANTI-FUNGAL PHYTOCHEMICAL PDHC (PROPANE-DIYL-BIS-HEXAHYDRO-ISOCHROMENE) ISOLATED FROM ALTERNANTHERA SESSILIS LEAVES
This study reports the potential of Alternanthera sessilis leaves as antioxidant, antimicrobial, anti-inflammatory and anti-diabetic agent and also the characterization of a novel phytochemical from A. sessilis using bio-activity guided extraction. Antimicrobial property was studied against five bacterial pathogens, Escherichia coli (MTCC: 1687), Bacillus cereus (MTCC: 0430), Klebsiella pneumonia ...
EVALUATION OF THE AMELIORATIVE EFFECT OF ALPINIA OFFICINARUM METHANOL EXTRACT IN AN EXPERIMENTAL MODEL OF DEPRESSION
The active ingredient flavonoids especially Flavones, e.g., Quercetin was identified from the methanol extract of Alpinia officinarum. This study evaluates the antidepressant activity of Alpinia officinarum (L.) wild Hance (Zingiberaceae) in Swiss Albino mice models. The antidepressant activity was evaluated by using different animal models viz. tail suspension test, despair swim test, potentiatio...
MICROWAVE-ASSISTED SYNTHESIS OF IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR ANTI-INFLAMMATORY ACTIVITY
A series of novel Imidazo[1,2-a]pyridine derivatives were synthesized in satisfactory yield by microwave assisted synthetic method. The structures of the newly synthesized compounds are characterized by 1H-nuclear magnetic resonance (NMR), Fourier transformed infrared (FTIR), mass spectral analysis (LC-MS) and screened for their in-vitro anti-inflammatory activity. Among the synthesized compounds ...
ANTIDIABETIC POTENTIAL OF ABELMOSCHUS ESCULENTUS LINN. IN ALLOXAN- INDUCED DIABETIC RATS
Abelmoschus esculentus Linn. (Malvaceae) is described in medicine for the treatment of diabetes mellitus. The monech seeds of Abelmoschus esculentus having potential in the development of a drug for diabetes due to their antidiabetic activity. The hypoglycemic effect of the extract was tested in normal, glucose loading and alloxan-induced diabetic rats. Aqueous and ethanolic extracts (250 and 500 ...
STUDY OF FORCED DEGRADATION BEHAVIOUR OF A NOVEL PROTEASOME-INHIBITING ANTICANCER DRUG BY LC-MS AND DEVELOPMENT OF A VALIDATED STABILITY-INDICATING ASSAY METHOD
In the present study, comprehensive stress testing of Carfilzomib, a newly approved proteasome-inhibiting anticancer drug was carried out according to ICH guideline Q1A (R2). The drug was subjected to acid (0.1N HCl), neutral and alkaline (0.1N NaOH) hydrolytic conditions at 70 ºC, as well as to oxidative decomposition at room temperature. Photolysis was carried out in 0.1N HCl, water and 0.1N Na...
IDENTIFICATION OF ACTIVE PHARMACEUTICALS OF SIDA ACUTA BURM. F. LEAVES USING GC-MS AND HPTLC FINGERPRINTING
Sida acuta is one of the medically active plants used for the treatment of multifaceted diseases. However, an elaborated investigation on the phytochemical composition of the ethanolic extract of the leaves of this plant is yet to be deciphered. So, in this quantification of phytochemicals, in-vitro free radical scavenging activity, enzymatic and non-enzymatic antioxidant levels in the fresh leave...
FORMULATION AND IN-VITRO CHARACTERIZATION OF AMBROXOL HYDROCHLORIDE SUSTAINED-RELEASE MATRIX TABLETS
The present study involves the formulation and in-vitro characterization of sustained release matrix tablets of Ambroxol hydrochloride, a potent mucolytic agent used in the treatment of respiratory disorders. FTIR analysis confirmed the absence of drug-polymer interactions. Sustained release matrix tablets containing 75 mg were formulated employing HPMCK15 and xanthan gum as release retarding poly...
AN EFFICIENT SYNTHESIS OF SOME NOVEL BIOACTIVE AZETIDINONE DERIVATIVES INCLUDING 5-(BENZOFURAN-2-YL) AND 1-PHENYL-1H-PYRAZOLE-3-CARBOXAMIDE MOIETY
In continuation of our efforts in the development of novel drugs, in the present article we have described synthesis of a series of novel azetidinones derivatives (4a-i) containing 5-(benzofuran-2-yl) and 1-phenyl-1H-pyrazole-3-carboxamide moiety, with excellent yields and without formation of undesirable side products from cyclo condensation reaction of N'- (benzylidene) -5- (benzofuran- 2- yl) -...
ANTIBACTERIAL AND ANTIVIRAL PROPERTIES OF SILVER NANOPARTICLES SYNTHESIZED BY MARINE ACTINOMYCETES
Present work has been conducted to evaluate antibacterial and antiviral activity of silver nanoparticles using marine Actinomycete, Nocardiopsis alba, isolated from mangrove soil. Formation, size, and shapes of silver nanoparticles (AgNPs) were characterized by UV-visible spectroscopy, X-Ray Diffraction (XRD), FTIR and Transmission electron microscope (TEM). From the UV-visible spectroscopy, the a...
A NOVEL RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DICYCLOMINE AND ETHYL MORPHINE IN BULK AND PHARMACEUTICAL FORMULATION
The present study was designed to develop and validate a simple, sensitive, precise and accurate RP-HPLC method for simultaneous estimation of dicyclomine and ethylmorphine in bulk and tablet dosage form. The chromatographic separation was achieved on Discovery C18 column (250 × 4.6 mm, 5 µm) as stationary phase with a mobile phase of water (pH 5.4 adjusted with orthophosphoric acid): acetonitri...
PHYTOCHEMICAL, CYTOTOXICITY AND DOCKING STUDIES OF SAMANEA SAMAN
Samanea saman is a tropical avenue tree which is widely cultivated in Northern America, and Asia belongs to the family Leguminosae. It possesses a wide range of biological perspectives. Folklore claims postulated that Samanea saman is having an antiulcer, antioxidant antibacterial and anti-mycobacterial properties. In the present investigation, the methanol extract of leaves of Samanea saman has b...
IN-SILICO DOCKING ANALYSIS OF PHYTOCHEMICALS FROM VERBASCUM PHLOMOIDES L. AS AN ANTIVIRAL AGENTS AGAINST HERPES SIMPLEX VIRUS TYPE I AND TYPE II
Almost 85% of the world population is infected with the Herpes Simplex Virus (HSV). Herpes simplex virus infections have been described in the medical literature for centuries, yet the drugs available nowadays for therapy are largely ineffective and low oral bioavailability plays an important role on the inefficacy of the treatments. Additionally, the details of the inhibition of Herpes virus type...
BIOCONVERSION OF ORANGE PEEL WASTE BY ESCHERICHIA COLI AND SACCHAROMYCES CEREVISIAE TO ETHANOL
An alternative energy sources using the sweet orange (Citrus sinensis (L.) waste as the feedstock was investigated; this is an approach to environmental protection. The extraction of pectin from sweet orange peel waste (pith) and the production of ethanol from the resultant liquid pectin with the aid of Escherichia coli (E. coli) and Saccharomyces cerevisiae (yeast) were carried out. Dried pith wa...
ANALYSIS OF CUTANEOUS ADVERSE DRUG REACTIONS PRESENTING TO THE DERMATOLOGY DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL: A PROSPECTIVE, OBSERVATIONAL STUDY
Background: Cutaneous adverse drug reactions (CADRs), having a wide range in terms of its spectrum, are an important cause of morbidity and mortality. They comprise 2-3% of all ADRs. This study was conducted to analyze various parameters of CADRs at our setup. Methodology: This prospective, observational study was carried out for 1 year at our setup after ethical approval. Those diagnosed as CADRs...
ANTI-ATHEROSCLEROTIC BIOACTIVE COMPOUND FROM A MARINE MOLLUSC, CHICOREUS SP.
This study reports the potential of a marine mollusk, Chicoreus sp., as a producer of peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand that activate the scavenger receptor class B type 1 (SR-B1) for anti-atherosclerotic activity. The objective of this study is to determine the cytotoxicity of the obtained compound C35, with a molecular weight of 270.1 and the level of SR-B1 expres...
QUALITY ASSESSMENT OF VRANROPAN TAILA: AN AYURVEDIC SIDDHA TAILA FOR WOUND HEALING AND ANTI-MARK PROPERTY
Standardization can create trust and confidence in the products and increase market relevance. It is an essential requirement for the open exchange of information; without it, the network will simply not work. The practitioner, as well as the consumer, now seeks assurance from the manufacturer about the quality, safety, and efficacy of a readymade Herbal supplement or Ayurvedic formulations. An av...
QUANTITATIVE ESTIMATION OF TOTAL PHENOLIC CONTENT OF TWO SPECIES OF PORTULACA OBTAINED BY USING MICROWAVE ASSISTED EXTRACTION AND ITS VALIDATION
Portulaca oleracea and Portulaca quadrifida have been used traditionally have been used for their pharmacological properties and consumed as a part of the diet. Anti-oxidative property of phytochemicals might play a role in their observed benefits, and phenolic compounds are known to be the major contributors towards the anti-oxidant property of phytochemicals. The objective of this study was to q...
PROTECTIVE EFFECTS OF ALOE VERA AGAINST RADIATION INDUCED BIOCHEMICAL DISORDERS IN LIVER OF SWISS ALBINO MICE
In this study, radioprotection against radiation-induced hepatic damage in Swiss albino mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals. Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation...
FORMULATION AND EVALUATION OF LIQUISOLID COMPACT OF CANDESARTAN WITH β-CYCLODEXTRIN
The liquisolid technique was chosen to enhance the dissolution properties of Candesartan. The study aimed to investigate the complexation of Candesartan with β-cyclodextrin in improving the dissolution profile of Candesartan. Candesartan is a BCS class-II drug. The inclusion complexes were formed by physical mixing (1:1 ratio). Liquisolid compacts were prepared by using, propylene glycol, tween 2...
FORMULATION AND EVALUATION OF FLOATING GEL BEADS OF LORATADINE
A floating controlled drug delivery system of loratadine was formulated to enhance the retention time in the stomach and to modify the release characteristics of loratadine. Loratadine loaded floating gel beads were prepared by ionic gelation technique using different polymers such as HPMC K4M, HPMC K15M, and carbopol 934P in different proportions and sodium bicarbonate as the gas forming agent. F...
DEVELOPMENT AND VALIDATION OF A HPLC ANALYTICAL METHOD FOR DETERMINATION OF ELLAGIC ACID IN EPILOBIUM ANGUSTIFOLIUM EXTRACT
Development of quality assessment parameters for natural products is a prominence necessity to justify their acceptability and activity. Establishment of authentic and reliable analytical methods which profile the quantitative phytochemical composition of marker constituents in multicomponent composition like extract is a challenging task. A simple, rapid, precise, and reliable HPLC method was dev...
PRODUCTION OF XYLANASE BY PENICILLIUM SP. AND ITS BIOBLEACHING EFFICIENCY IN PAPER AND PULP INDUSTRY
The main objective of this study is to evaluate the ability of production of xylanase by a fungal strain Penicillium sp. isolated from decaying wood. Xylanases are hydrolytic enzymes produced by many microorganisms which catalyze the hydrolysis of xylan polymer to xylose monomer. The xylanase production was carried out under submerged fermentation xylose as the main substrate, and the enzyme yield...
IDENTIFICATION AND HPLC QUANTIFICATION OF AFLATOXINS IN GROUNDNUT (ARACHIS HYPOGAEA L.) SAMPLES COLLECTED IN RAYALASEEMA AREA, ANDHRA PRADESH
The present investigation reports the fungal Aflatoxins contamination in groundnut samples collected in different locations in the Rayalaseema area, Andhra Pradesh, India. Aflatoxins were extracted by liquid-liquid extraction method using chloroform solvent. The qualitative and quantitative analysis of aflatoxins present in the samples was done using TLC and HPLC techniques. Among the eight sample...
ASSESSMENT OF PRESCRIBING PATTERN OF ANTIEPILEPTICS IN PAEDIATRIC IN-PATIENTS OF A TERTIARY CARE HOSPITAL
Purpose: To study the prescribing pattern of AEDs for a different type of seizures in the pediatric population and disease conditions other than epilepsy and to identify the drug interactions with the use of AEDs among the study population. Methods: This six months long prospective observational study was conducted at in-patient wards of JSS Hospital. The case sheets of all in-patients were review...
SCIENTIFIC EVALUATION OF VALLI PANCHMOOLA – DIFFERENT COMPOSITIONS THROUGH PHARMACOGNOSTICAL AND PHYTOCHEMICAL METHODOLOGY
Objective: This study aimed at ensuring the different compositions of Valli panchmoola using authentic herbs and establishing pharmacognostical, physicochemical, and phytochemical standards for the compositions. Methods: Compositions of Vallli panchmoola were prepared as per the formula and procedure mentioned in traditional texts and Ayurvedic Formulary of India. The prepared compositions were ev...
SPECTROPHOTOMETRIC DETERMINATION OF ETODOLAC USING CHARGE TRANSFER COMPLEX
In this study, we developed a cheap and precise analytic method to measure Etodolac concentration in bulk and pharmaceutical formula. The modified, updated method depends on the reaction between ferric ion and Etodolac to yield ferrous ion. Then the former ion reacted with potassium ferric cyanide to form colored compound has a maximum absorbance at 700 nm. The method was validated by calculating ...
ASSOCIATION BETWEEN VITAMIN D RECEPTOR FOKI POLYMORPHISM AND CHRONIC PERIODONTITIS IN SYRIAN POPULATION
Background: Chronic periodontitis (ChP) is the most common form of periodontal diseases. The progression rate may be influenced by local, systemic conditions and environmental factors that can alter the normal host response to bacterial plaque and affect the susceptibility to disease. Several studies have reported a role for vitamin D receptor (VDR) gene polymorphisms in numerous immunological act...
EVALUATION OF α-AMYLASE AND α-GLUCOSIDASE ENZYME INHIBITORY ACTIVITIES OF TRICHURIELLA MONSONIAE BENNET
Diabetes is a noncommunicable chronic metabolic disorder characterized by high blood glucose level in the body. One of the antidiabetic therapeutic strategies is the inhibition of carbohydrate-digesting enzymes such as α-amylase and α-glucosidase. In the present study methanolic extract and its two fractions (Ethyl acetate and n-butanol) of the whole plant of Trichuriella monsoniae were evaluate...
PHYTOCHEMICALS AND IN-VITRO ANTIOXIDANT ACTIVITY OF HALOPHILA BECCARII
Free radicals induce numerous diseases by lipid peroxidation, oxidation of monosaccharides and DNA damage. In the present study, the marine plant seagrass Halophila beccarii was exploited to detect the phytochemical constituents and its antioxidant potential. The aqueous and organic extracts of Halophila beccarii portrayed the presence of various metabolites such as phenolic compounds, flavonoids,...
FORMULATION, EVALUATION AND CYTOTOXIC POTENTIAL OF METRONIDAZOLE LOADED POLOXAMER 407 HYDROGEL IN SCC-29 CELL LINES
The present research work was planned to formulate poloxamer 407 based hydrogel formulations of metronidazole and the evaluation of various parameters like swelling behavior, drug PH stability, in-vitro and in-vivo drug release, and in-vitro cytotoxic activity. Two different concentrations of metronidazole hydrogel formulations were prepared using poloxamer 407 and were assessed by a validated HPL...
TRANSMISSION OF HEPATOCURATIVE EFFECT OF SPILANTHES ACMELLA EXTRACT BASED GEL
Spilanthes acmella (SA) commonly known as “Akarkara” frequently available in most of the areas of India, Sri Lanka, Bangladesh, China, Japan, and Thailand; is well reputed in the indigenous system of medicine for its medicinal use in toothache and rheumatic fever. The present study was aimed to evaluate its traditional use in liver diseases using the in-vivo model of rabbits. The Spilanthes ac...
EFFICACY OF TWO AYURVEDA DRUG REGIMENS FOR UTERINE FIBROIDS, A RANDOMIZED, SINGLE BLIND, THREE-ARM, CLINICAL TRIAL- STUDY PROTOCOL
Uterine fibroids are the most common genital tract tumor in reproductive age women. The main treatment option for fibroid is surgical intervention. Options for medical therapy are currently limited to preoperative reduction of symptoms related to uterine bleeding and fibroid size. Ayurveda treatment for this condition is widely practiced in Sri Lanka. We aimed to evaluate the efficacy of two Ayurv...
ANALYSIS OF QUORUM QUENCHING POTENTIAL OF EUPHORBIA TRIGONA MILL.
S. marcescens and P. mirabilis are gram-negative bacteria responsible for nosocomial infections. Quorum sensing regulates virulence in S. marcescens and P. mirabilis. Present study documents the potential of E. trigona extracts in inhibiting quorum sensing in both the bacterial species. Extracts of aerial part of the plant were prepared in petroleum ether, chloroform, ethyl acetate, acetone and me...
METHOD DEVELOPMENT AND VALIDATIONS OF APIXABAN IN BULK AND ITS FORMULATIONS BY UV-SPECTROSCOPY (AREA UNDER CURVE)
The aim of the present research work is to validate the apixaban content in bulk and pharmaceutical dosage formulation and validate it as per ICH guidelines. A simple, rapid, precise and highly selective spectrophotometric method was developed for estimation of apixaban in tablet dosage form by the area under curve method. The area under curve method involves the measurement of absorbances of apix...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF HALOBETASOL PROPIONATE AND MUPIROCIN IN THE RATIO 1:40 BY U.V. SPECTROSCOPY AND RP- HPLC METHOD
The present work encompasses the development of two classical UV spectroscopy methods and an RP-HPLC method for the concurrent assessment of Halobetasol propionate and Mupirocin inculcating a statistical approach. The UV spectroscopy methods developed herein include absorption ratio method and first derivative spectroscopy method. The wavelength maxima selected for Absorption ratio method were 240...
FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILMS OF LOSARTAN POTASSIUM USING 32 FACTORIAL DESIGN
The objective of the present study was to develop mouth dissolving films (MDF) of Losartan potassium for the treatment of hypertension, with fast disintegration, optimum morphological properties, and mechanical strength. Losartan is an anti-hypertensive drug which undergoes extensive first-pass metabolism that results in low bioavailability of the drug. Through buccal route, the drug directly ente...
PROTECTIVE EFFECT OF BAUHINIA TOMENTOSA L. EXTRACT AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN WISTAR MALE ALBINO RATS
The aim of the present study was to explore the effect of aerial parts of Bauhinia tomentosa extract against gentamicin-induced nephrotoxicity. Thirty male Wistar albino rats were divided into five groups of six animals each. Animals served as Group I (normal control 5 ml/kg b.wt, p.o), Group II (toxic control), and Group III and IV (treatment groups 200 and 400 mg/kg b.wt, p.o) and Group V (stand...
METABOLIC SYNDROME: PREVALENCE (IDF & NCEP-ATP III) IN UDHAMPUR, JAMMU CITY
Aim: To determine the prevalence of metabolic syndrome in Udhampur, J & K population according to two different criteria’s (IDF & NCEP-ATP III). Methods: A cross-sectional survey was conducted for the prevalence of metabolic syndrome among 210 participants. A pre-designed questionnaire was used to collect data, including demographic information; physical activity and biochemical paramete...
IN-VITRO ANTIOXIDANT POTENTIAL OF SELECTED NUTRACEUTICALS
The current study involves evaluation of antioxidant potential of selected nutraceuticals like barley grass juice (Hordeum vulgare L.), ethanolic extracts of cashew apple (Anacardium occidentale L.) and sea lettuce (Ulva reticulata F.) in in-vitro experimental model using goat liver slices at different concentrations (100, 200, 400, 800 and 1600 mg/kg, p.o). The oxidative stress was induced using ...
COMPARATIVE ANTIANXIETY POTENTIAL OF EUPHORBIA NERIIFOLIA LINN. LEAVES AND EUPHORBIA HIRTA LINN. AERIAL PARTS
Euphorbia neriifolia and Euphorbia hirta have been traditionally used for relieving anxiety and other nervous disorders. The present study was designed to evaluate and compare the antianxiety activity of E. nerrifolia leaves and E. hirta aerial parts using elevated plus maze model. Petroleum ether (60-80°C), chloroform, ethanol and aqueous extracts of both the plants were prepared and evaluated f...
HIGHLY SELECTIVE AND SENSITIVE DETERMINATION OF Cr6+ (nM) IN GELATIN CAPSULE USING AgF/Ag2WO4 NANOCOMPOSITE
The present work deals with a novel synthesis of AgF/Ag2WO4 nanocomposite by co-precipitation method. The morphology and size of the synthesized AgF/Ag2WO4 nanocomposite were confirmed by Ultraviolet-Visible (UV-Vis) spectroscopy, Fourier Transform-Infrared (FT-IR) spectroscopy, Transition Electron Microscopy (TEM) and X-Ray Diffraction (XRD) analyses. The performance of the nanocomposite was succ...
ENHANCED MECHANISM OF METAL NANOPARTICLES USING SYZYGIUM CUMINI AS A POTENTIAL SYNTHESIZER AND ITS INHIBITORY EFFECT
In recent years metallic nanoparticles, represent one of the most comprehensively studied materials because of their application in biology The synthesis of silver nanoparticles using biological entities has received immense attention in the area of research. Medicinal plants have attracted interest over antibiotics due to a rapid increase in the rate of infections, development of antibiotic resis...
PHARMACOKINETIC STUDIES OF SECNIDAZOLE IN THE PRESENCE OF PIPERINE AND ITS SYNTHETIC DERIVATIVE
Piperine has been widely used as a bioenhancer. Secnidazole is a long-acting 5-nitroimidazole analog. It is used in the treatment of amoebiasis, giardiasis, trichomoniasis and anaerobic bacterial infection. In this study derivative of piperine was synthesized and studied for its bio enhancing the effect and this effect was compared with the bioenhancing effect of piperine. The pharmacokinetic prof...
FORMULATION AND EVALUATION OF TOOTHPASTE CONTAINING COMBINATION OF ALOE AND SODIUM CHLORIDE
The formulation and evaluation of toothpaste contain Aloe vera along with the combination of sodium chloride. Aloe vera shows a number of uses either internally or externally, and the number of uses also increases as the research going on. In this formulation, we tried to find out the antimicrobial activity of Aloe vera in toothpaste formulation, for the said purpose we use S. aureus culture. Afte...
DRUG UTILISATION EVALUATION OF CORTICOSTEROIDS IN TERTIARY CARE TEACHING HOSPITAL
Objective: Steroids are widely prescribed and used by practitioners due to powerful anti-inflammatory and immunosuppressive actions. So, care should be exercised in the rational selection of steroids. The main aim of our study is to assess prescribing patterns, demographic and clinical variables such as drug interactions associated with corticosteroid administration and steroidal use in a tertiary...
THE SYNTHESIS OF QUINAZOLON-1,3,4-OXADIAZOLE ANALOGUES AND STUDIES OF THEIR ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY
A series of conjugation of two heterocycles 1, 3, 4-oxadiazole and quinazolone were synthesized and screened for antimicrobial as well as antioxidant activity. Compound4-(4-oxo-2-phenyl-quinazoline-3(4H)-yl)-benzohydrazide 3 on cyclization with different aromatic acids in the presence of phosphoryl chloride (POCl3) give different 1, 3, 4-oxadiazole derivatives. Similarly, compound 3 on reaction wi...
DEVELOPMENT OF MALTODEXTRIN BASED PRONIOSOMES DERIVED NIOSOMES OF OFLOXACIN
Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery. The advance in nanotechnology helps in the preparation of new pharmaceutical formulations with high benefits. One of its approaches is to stabilize the niosomal drug delivery system without affecting its properties have resulted in the development of proniosomes,...
DESIGN AND DEVELOPMENT OF DANTROLENE SPHERICAL AGGLOMERATES FOR IMPROVEMENT IN BIOAVAILABILITY
The purpose of this research was to obtain directly compressible agglomerates of Dantrolene using spherical agglomerates. Spherical agglomeration technique enables simultaneous crystallization and agglomeration. Sodium hydroxide acted as a good solvent, aqueous solution of PEG 6000 in hydrochloric acid served as bad solvent and isopropyl acetate was used as bridging liquid. The optimization of for...
DESIGN AND DEVELOPMENT OF ANTI-DIABETIC TABLET FORMULATION CONTAINING SPRAY DRIED EXTRACT OF MULBERRY LEAVES
Diabetes is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. The chronic hyperglycemia in diabetes is associated with long term damage, dysfunction, failure of kidney, nerves and blood vessel. Nowadays, herbal treatments available for diabetics are eroding the share of allopathic formulations. Cur...
EFFECT OF METFORMIN AND ROSUVASTATIN ON ERYTHROCYTES OF PATIENTS WITH SICKLE CELL DISEASE: AN IN-VITRO STUDY
Objectives: Sickle cell disease (SCD) is a common hereditary blood disease with a progressive clinical course and multiple end organs damage. Due to its intercalated pathophysiology, several trials have been conducted targeting its pathophysiology in an attempt to modify the clinical course and minimize complications. Metformin and rosuvastatin are known to have pleiotropic effects such as antioxi...
ESTIMATION OF PROTEINS IN PLANTS OF FORENSIC SIGNIFICANCE (RICINUS COMMUNIS AND CANNABIS SATIVA) BY UV-SPECTROPHOTOMETRY AND GEL ELECTROPHORESIS METHOD
Proteins play a significant role in living beings. In animals, where proteins are involved in the body built, the formation of tissues, organs, etc., in plants, proteins regulate the respiration, photosynthesis, growth, and reproduction. There are some proteins which are specific to the plant or a particular species of plant. Proteomics is a multidisciplinary branch of science that deals with the ...
ANTIOXIDANT MEDIATED ULCER HEALING POTENTIAL OF HYPERIN ISOLATED FROM FLOWERS OF RHODODENDRON ARBOREUM IN EXPERIMENTAL RAT
Hyperin, a flavonoid is an active phytochemical constituent gift in numerous plants as well as, Hypericum perforatum, Drosera rotundifolia, Stachys byzantina, Prunella vulgaris, Rumex acetosella, Abelmoschus manihot and Rhododendron arboreum. It’s protecting result on cultured PC12 cells against toxicity induced by hydrogen peroxide and tert-butyl hydroperoxide. Hyperin, isoquercitrin and querce...
IN-VITRO ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS OF BARK OF FICUS RACEMOSA LINN. (MORACEAE)
The plant Ficus racemosa L., is a woody large deciduous tree distributed all over India, and grows in the evergreen forest, moist localities, along with the sides of ravines and banks of streams belonging to the family Moraceae, locally know as Attimara and Hindi known as Gular. Ethnobotanically the bark used for anti-diabetic, wounds, useful in asthma and piles recommended in uropathy and treatme...