Volume 11 (2020) - Issue 9, September
CONVALESCENT PLASMA THERAPY: A PROMISING APPROACH IN THE TREATMENT OF COVID-19
At present, the whole world fronting a very challenging situation of the pandemic, severe acute respiratory syndrome due to coronavirus (COVID-19). Today, COVID-19 is spreading rapidly in every part of the world; these pandemic affected billions of people. This virus is found as a new human pathogen. However, currently, there is no hasty therapy available, which will provide fruitful results in th...
POTENTIAL DRUG CANDIDATES FOR TREATMENT OF COVID-19
The late December of 2019 witnessed an outbreak of viral pneumonia of unknown etiology (VPUE) in the Wuhan city of Hubei province, China. Later it was identified as a novel strain of β-genus Coronavirus, which is similar to the Severe Acute Respiratory Syndrome (SARS) virus, which was a global pandemic during 2002-03. This novel coronavirus is rapidly spreading with an R0 of 2 and has an incubati...
INHALATION OF ESSENTIAL OILS: COULD BE ADJUVANT THERAPEUTIC STRATEGY FOR COVID-19
The current pandemic of the novel coronavirus (SARS-CoV-2) termed as COVID-19 is the third recorded blowback of an animal coronavirus to a human being in the last twenty years. The pandemic is originated from China and currently impacted more than 205 countries worldwide (as on dated 2nd April 2020). This pandemic is not only affecting human life but also has questioned the worldwide status of hea...
THE NOVEL CORONA VIRUS (nCoV2) SEEMS TO DEFY ALL LAWS OF VIROLOGY
Amongst the known coronaviruses, many were responsible for causing disease in humans knowingly from the common cold to acute severe respiratory syndrome. The novel coronavirus, nCoV-2 has been implied to cause increasingly severe damage to public health besides demolishing the global economy with a staggering figure of continuous rise in mortality within the afflicted cases in almost every country...
MANAGEMENT AGAINST COVID-19 THROUGH NUTRITIONAL SUPPLEMENTATION TO BUILD ADAPTIVE IMMUNITY – A SYSTEMATIC REVIEW
As humanity is progressing, many new borne infections are borne, and the stability and efficiency of the human body are being tested. Today the World is fighting with a deadly Novel infection named Corona Virus Disease. The aim of this systematic review is to find out the efficacy of Nutritional Interventions against the infections caused in the body due to pathogens. Further, the recommendations ...
CHIA SEED IN HEALTH AND DISEASE PREVENTION: PRESENT USAGE AND FUTURE PERSPECTIVES
Salvia hispanica L. Well known as chia is gaining popularity day by day due to its nutritional value. This plant is native to Mexico, belonging to family Labiatae / Laminacea, and it was used as a superfood from ancient times. Chia is valued more due to its oil content as it consists of omega -3-alpha linolenic acid in higher amount along with various types of other nutrients, e.g., proteins, diet...
ENDOPHYTIC FUNGI FROM MANGROVES – REVIEW
Mangrove plants are used in medicines, and extracts from mangrove species have proven inhibitory activity against human, animal, and plant pathogens. Endophytic fungi are an important component, are universal, and occur within all know plants, including a broad range of hosts in various ecosystems, and therefore play an important role in the natural environment. Numerous species of mangrove produc...
EMPAGLIFLOZIN: A REVIEW ON ANALYTICAL AND BIO-ANALYTICAL METHODS
Diabetes mellitus is a metabolic disorder that causes high levels of blood glucose level in that 90% of the diabetic population accounts for type 2 diabetes mellitus it also has secondary complications like Cardiovascular disorder, Renal impairment, and susceptibility to infections. Empagliflozin is a potentially highly selective Sodium-glucose co-transportace-2 (SGLT-2) inhibitor used for the tre...
VERSATILITY OF BENZIMIDAZOLE AND ITS DERIVATIVES; AN INSIGHT
Benzimidazole, a fused heterocyclic moiety containing benzene and imidazole, has gained considerable attention in the field of medicinal chemistry due to its wide array of pharmacological activities. Be it as a antifungal, anticancer agent, proton pump inhibitors, anthelmintic, anti-microbial, analgesic, it has become an intrinsic part of the pharmaceutical world. The presence of Nitrogen in its h...
MEDICATED TATTOOS: A RECENT DRUG DELIVERY APPROACH IN MEDICAL SCIENCE
Trandermal drug delivery systems are potential sources of administrating drugs through and have certain advantages as delivering a therapeutically effective amount of drug across a patient's skin. Medicated Tattoos is one of the upcoming approaches in transdermal drug delivery. Researches reveal that humans from the generations have used tattoos for various reasons like symbol of rank, religious/s...
A BRIEF REVIEW ON RECENT ADVANCEMENTS AND BIOLOGICAL ACTIVITIES OF ARYL PROPIONIC ACID DERIVATIVES
Arylpropionic acid derivatives are an important class of NSAIDs. Ibuprofen, 2- (4-isobutylphenyl) propionic acid, is known as NSAIDs. Arylpropionic acid derivatives have a broad biological activity, including antibacterial, anticonvulsant and anticancer activity, analgesic, and anti-inflammatory. In addition to the most powerful ingredients used in analgesic and antipyretic fields, such as ibuprof...
PRESENT SCENARIO OF HEPATOPROTECTIVE POTENTIAL OF MEDICINAL PLANTS: AN UPDATED REVIEW
The liver is the principal site for metabolism and excretion in the body. The human liver metabolizes substances by various biochemical pathways, including oxidation, reduction, hydration, condensation, hydrolysis, conjugation or isomerization. Disorder of any of therefore mentioned process may lead to liver cell injury, what we call as hepatotoxicity, which in turn leads to many diseases. Such di...
EFFICACY AND MECHANISM OF ACTION OF MORINGA OLEIFERA IN DIABETES
Diabetes mellitus (DM) is a globally spreading metabolic disorder with a high incidence rate. About 425 million cases took place in 2017 and expected to rise up to 693 million by 2045. In diabetes, the patient elevation of blood glucose level occurs due to the deformation of insulin receptor action/secretion or both. Long term increases in blood glucose level causes chronic effects such as dysfunc...
GARLIC (ALLIUM SATIVUM): PHARMACEUTICAL USES FOR HUMAN HEALTH
The medicinal properties of Garlic are well known for a long time. Garlic is recommended as a nutritive element in the treatment of various health problems and the prolongation of human life. The present review article on garlic is to explore ancient phytomedicinal uses with modern scientific knowledge. Garlic cloves contain a colorless, odorless, soluble compound called alliin, water, and vascula...
BIOELECTRONIC MEDICINES: INNOVATION IN DISEASE TREATMENT
Innovation in technology is required to change the world. Bioelectronic medicine is the consolidation of molecular medicine, neuroscience, engineering, and computing to develop a device to diagnose and treat diseases. The mechanisms of Bioelectronic medicine for neural control of a biological process that underlie disease and the development of devices to modulate these speciﬁc neural circuits a...
SUSTAINABLE USE OF HIGH ALTITUDE MEDICINAL AND AROMATIC PLANT FOR SOCIO-ECONOMIC DEVELOPMENT IN UTTARAKHAND: A REVIEW
The present paper reveals the socio-economic benefits for the peoples of the Uttarakhand state. The demand for medicinal and aromatic plants of Uttarakhand is quite inflated, and many of these plants grow only in the Himalayan states. The State has diverse agro-geo climate conditions, which is most suitable for Medicinal and aromatic plant cultivation. Uttarakhand is blessed with a variety of soil...
A STATE OF THE ART REVIEW ON SELF EMULSIFYING DRUG DELIVERY SYSTEM
Solubility plays a vital role in achieving the therapeutic efficacy of a drug from a dosage form. Advances in molecular screening techniques for identification of potential drug molecules investigated an increased number of new pharmacologically active lipophilic compounds that are poorly water-soluble about 40% of new chemical entities have been discovered as poorly water-soluble. Numbers of tech...
MOLECULAR DOCKING STUDY REVEALS THE POTENTIAL REPURPOSING OF HISTONE DEACETYLASE INHIBITORS AGAINST COVID-19
The outburst of new coronavirus (COVID-19) infections, firstly appeared in Wuhan in 2019, has massively expanded to the whole world. At the end of March 2020, the rapid spread of the infection happened in about 206 countries around the globe. At the moment, the statistics of WHO on coronavirus pandemic revealed total infected cases of 21,770,000 and more than 77,000 deaths all over the world, with...
C-PHYCOCYANIN OF SPIRULINA PLANTESIS INHIBITS NSP12 REQUIRED FOR REPLICATION OF SARS-COV-2: A NOVEL FINDING IN-SILICO
SARS-CoV-2 or COVID-19 is one of the deadly pandemics faced by the world population, which has infected 7 million and claimed the lives of 0.4 million people. In spite of a few drugs available to control the pandemics, a formal vaccine is the least that the world expects under the current scenario. However, the release of a vaccine is expected to come at the cost of its own time. SARS-CoV-2 replic...
MOLECULAR VERSUS CONVENTIONAL TECHNIQUES FOR THE DETECTION OF STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA AND CANDIDA ALBICANS IN NON-STERILE PHARMACEUTICAL PREPARATIONS
Notable progress has been made in methods that encourage the use of PCR as a rapid and accurate tool in quality evaluation of pharmaceuticals. In this study, monoplex and multiplex PCR based assays were developed and compared with standard conventional methods for rapid detection of three specified topical indicator pathogens, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, in...
PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC AND THROMBOLYTIC ACTIVITY OF THE CRUDE METHANOLIC EXTRACT OF CALAMUS ROTANG L. LEAVES (ARECACEAE)
Medicinal plants abound with many phytochemicals that are effective in representing lots of pharmacological activities. The current study aimed at investigating the phytochemical and pharmaco-logical activity of crude methanol extract of Calamus rotang L. (CRME) leaves. The analgesic activity and thrombolytic activity were examined by the acetic acid-induced writhing method, while the clot lysis e...
THE EFFECT OF KEREHAU LEAF EXTRACT (CALLICARPA LONGIFOLIA LAMK.) ON LIPID RATIOS AND AORTA HISTOPATHOLOGY OF MALE RATS OF WISTAR STRAIN
Ethanol extract of kerehau leaves is known to have anti-inflammatory and antioxidant activities with the potential to prevent atherosclerosis. This study aims to determine the ability of kerehau ethanol extract in reducing the lipid levels, the lipid ratios, and the number of foam cells in the blood vessel walls. This study employed in-vivo and ex-vivo experiments on male rats of Wistar strain ind...
BIOLOGICALLY SYNTHESIZED SILVER NANOPARTICLES OF CURCUMA CAESIA ROXB. RHIZOME EXTRACT AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITY AGAINST MDR BACTERIA
Multidrug-resistant (MDR) bacterial infection is severe health concerns in the field of medicine. The researcher used green synthesized silver nanoparticles to overcome from MDR bacterial infection. Present study revealed successful synthesis of nanoparticles from Curcuma caesia aqueous rhizome extract by use of silver metal as a capping agent. Synthesized silver nanoparticles were identified by v...
IN-SILICO MODELING AND VALIDATION OF L-GLUTAMINASE ENZYME, AN ANTICANCER DRUG USING WEB-BASED COMPUTATIONAL TOOLS
The L-Glutaminase enzyme is a therapeutic agent that can be employed for the treatment of human cancer, specifically lymphocytic leukemia. Microbes are exploited commercially to produce L-Glutaminase on a large scale. The L-Glutaminase is an economic anti-cancer drug and can be easily administered into patients. The L-Glutaminase is also employed in food industries in the processing of fermented f...
ANTIDYSLIPIDEMIC AND ANTI-OXIDANT ACTIVITIES OF NIGELLA SATIVA SEEDS EXTRACT IN HYPERLIPIDEMIC RATS
This experimental study had approved by animal ethics of Central Drug Research Institute, Lucknow, and had undertaken to evaluate the antidyslipidemic and anti-oxidant activities of Nigella Sativa (N. Sativa), Hindi name Kalonji seeds extract in two models of hyperlipidemia. 1- triton and 2- cholesterol-rich high-fat diet (HFD) induced hyperlipidemia. N. Sativa and Gemfibrogil were macerated with ...
DESIGN AND DEVELOPMENT OF SUPERPOROUS HYDROGEL OF AN ANTIHYPER-TENSIVE DRUG FOR GASTRORETENTIVE DRUG DELIVERY
Superporous hydrogels (SPHs) is originally developed as a novel drug delivery system to retain drugs in the gastric medium by instant swelling on water absorption through open porous structure and maintain their integrity in that harsh environment. Atenolol, an antihypertensive drug with a short half-life, limited bioavailability, unstable nature at basic pH potentiated the need for developing a g...
COMMUNITY PHARMACISTS’ PERCEPTION AND EXPERIENCE IN PROVIDING LIFESTYLE ASSISTANCE TO PATIENTS WITH CARDIOVASCULAR DISEASE
Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Management of behavioral risk factors is recommended for primary and secondary prevention of CVDs. There is evidence that the involvement of community pharmacies in health promotion activities is successful. Objectives: This study was conducted to assess community pharmacists’ perception and current practice in pro...
A STRATEGY TO TREAT THE BREAST CANCER THROUGH INHIBITING THE OVER EXPRESSION OF PROTEIN ESTROGEN VIA SCHIFF BASE FUSED COUMARIN: AN IN-SILICO BASED SYNTHETIC APPROACH
Coumarin and its analogs have a wide range of attention in the treatment of hormone-dependent breast cancer by blocking the formation of estrogen through the inhibition of estrogen receptor. However, the Schiff bases are an important class of compounds with structural similarities of natural biological substances and also due to their presence of imine (-N=CH-), which have an impact on a biologica...
SUSTAINED RELEASE MULTI-PARTICULATES FORMULATION OF STEREO-SELECTIVE MOLECULE OF KETOPROFEN BY FLUID BED PROCESSOR
The aim is to prepare sustained release multi-particulates dosage form of Dexketoprofen trometamol, which is the active isomer of ketoprofen. Utilization of active moiety with minimum drug dose and administration frequency sustained-release multi-particulates dosage form is explored. Sustained release pellets of the dexketoprofen trometamol were developed by the fluidized bed technology, in which ...
ANTICHOLINESTERASE ACTIVITY OF PLANT EXTRACTS OF SMILAX ZEYLANICA AND SMILAX CHINA
Alzheimer’s disease is the most common neurodegenerative disease, which initially causes oxidative stresses and leads to neuronal death. It characterized by notable memory loss, cognitive impairment, and personality disorders accompanied by diffuse structural abnormalities in the brain of the aged population. The present work focused on anticholinesterase inhibiting activity Smilax zeylanica and...
FORMULATION AND PHYSICAL EVALUATION OF GLUCOCORTICOID LOADED TEA TREE OIL NANOEMULSION: A SUMMARIZED TECHNICAL NOTE
Clobetasol propionate (CP) has anti-inflammatory, immunomodulatory, and anti-proliferative activity. The current work aimed to prepare and evaluate the nanoemulsions of CP loaded tea tree oil (TTO) would be stable nanoemulsion. Clinical use of CP is restricted to some extent due to its poor permeability across the skin. So, to increase its permeation across the skin, microemulsion based formulatio...
QSAR STUDIES, SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLE DERIVATIVES CONTAINING THIOUREA AS TYROSINE KINASE INHIBITORS: AN APPROACH TO DESIGN ANTICANCER AGENTS
A series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(4-Amino-phenyl)-5-(3-nitro-phenyl)-4, 5-dihydro-pyrazole-1-carbothioic acid amide (AP-2) displayed the most potent EGFR inhibitory activity. The QSAR analysis of a set of these compounds tested for growth inhibitory activity ...
PHYSICOCHEMICAL STUDY AND DEVELOPMENT OF SOPs OF A POLYHERBAL UNANI FORMULATION: SAFŪF-I MU’ALLIF
In the Unani system of medicine, different dosage forms of the drug are used; out of them powder dosage form is known as Safūf, which is an important dosage form and has been used frequently since long. There are many Unani preparations used in the form of Safūf to treat various diseases. Safūf –I Mu’allif (SM) is a polyherbal Unani formulation that is known to be used as Spermatogenic agen...
ISOLATION OF CADMIUM DEGRADING MICROORGANISMS FROM ELECTROPLATING, STEEL AND BATTERY INDUSTRY
Increase in industrialization has raised the levels of heavy metal pollution in the country. In order to combat with this problem, many strategies were developed till date, and among them, the use of microorganisms is the most successful technique. The present study was undertaken for isolation, identification, and characterization of heavy metal (Cd) tolerant bacteria from industrial effluents of...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF FLUTICASONE PROPIONATE AND MUPIROCIN IN A COMBINED TOPICAL DOSAGE FORM
The objective of the present study was to develop and validate a precise and accurate reversed-phase high-performance liquid chromate-graphy for simultaneous estimation of for Fluticasone Propionate (FUP) and Mupirocin (MUP) in combined topical dosage form as per ICH guidelines. Chromatographic separation was achieved using HPLC Shimadzu, Japan, with column syncronis C18 (250 × 4.6 mm, 5 μm). Th...
EFFECT OF CHROMIUM ON IN-VITRO GROWTH AND ANTIOXIDANT POTENTIAL OF DIANTHUS CARYOPHYLLUS L.
Catalase, guaiacol peroxidase and polyphenol oxidase are antioxidant enzymes that are important in the metabolism of reactive oxygen species and can be induced by environmental stresses including chromium (Cr), heavy metal toxic to living organisms. In-vitro regenerated shoots of carnation (Dianthus caryophyllus L.) were exposed to K2Cr2O7, and the activities of these antioxidant enzymes were anal...
STRUCTURE ELUCIDATION OF OXIDATIVE DEGRADATION PRODUCT OF DROSPIRENONE
Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, LC-MS was done. Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, and LC-MS was done. To evaluate the stability of Drospirenone under stress conditions, it was subjected to oxidative degradation, according to ICH guideline Q1A (R2). The analysis was carr...
ETHNOBOTANICAL SURVEY OF MEDICINAL PLANTS USED FOR DISINFECTION OF PREMISES AND SURFACES IN THE FEZ-MEKNES CITIES (CENTRE OF MOROCCO)
The irrational and repetitive use of synthetic chemical disinfectants can contribute to the emergence of resistant strains and represent a risk to health and the environment. The aim of this ethnobotanical survey, a first innovative study, is exploring for plants with disinfecting power. An ethnobotanical study was conducted among herbalists in Fez and Meknes cities located in the center of Morocc...
EFFECTS OF ALLIUM SATIVUM ON BODY WEIGHT AND BIOCHEMICAL PARAMETERS IN HEALTHY RATS
This case-control study had undertaken to evaluate effect of Allium sativum in normal rats. In this study ethanol extract of Allium sativum had macerated with aqueous gum acacia (2%, w/v) suspension and fed orally (500 mg/kg b w p. o.) to male adult normal rats of charles foster strain for 15 days. Results of this study showing that alcoholic extracts caused no any significant reduction in blood g...
PHYTO-PHARMACOGNOSTICAL EVALUATION AND HPTLC FINGER-PRINTING PROFILE OF LEAVES OF SAPTAPARNA [ALSTONIA SCHOLARIS (L.) R. BR.]
Objective: We report the phyto-pharmacognostic evaluation and HPTLC finger-printing profile of the methanolic extract of Saptaparṇa [Alstonia scholaris (L.) R. Br.] leaves – unaffected and gall-affected, collected in January 2019. Materials and Methods: Physicochemical parameters and phytochemical screening were done by standard procedures. HPTLC finger-printing profile of the methanolic extra...
PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTI-DIARRHEAL POTENTIALITY OF PLUMERIA ALBA LINN. LEAVES
Plumeria alba Linn. belonging to the family Apocynaceae (Dogbane family) is the flowering plant. P. alba is used as a purgative, rubefacient in rheumatism, asthma, piles, gonorrhea, blood disorders and tumors, mentioned in the traditional system of medicine. The present study was carried out to establish the pharmacognostic studies, physicochemical parameters along with a preliminary phytochemical...
DEVELOPMENT AND EVALUATION OF PEPTIDE LOADED MUCOADHESIVE MICROSPHERES: IN AN EFFORT TO IMPROVE NASAL BIOAVAILABILITY OF PEPTIDE
The nasal drug delivery system has been a promising route for delivery of proteins and peptides as it can avoid degradation in the gastrointestinal tract and metabolism by liver enzymes. However, due to the rapid mucociliary clearance, the bioavailability of proteins and peptides is still low. Hence, mucoadhesive microspheres may prolong the residence time of peptide drugs in nasal cavity and impr...
ANTI-DIABETIC AND ANTI-OBESITY EFFECT OF FUNCTIONALLY ACTIVE PROTEINS OBTAINED FROM SEVEN EDIBLE INSECTS
The bioactive peptides derived from food have increased consideration for their function in averting numerous chronic diseases, comprising, diabetes and obesity. Edible insects are the feasible composition of bioactive peptides owing to their high protein content and viable production. The present study was aimed to evaluate the antidiabetic and anti-obesity effects of seven edible insects’ prot...
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SOME ARYL PIPERAZINE COMPOUNDS
In this planed research work, aryl piperazine derivatives will be synthesized because aryl piperazine currently the most important constructive block in drug discovery with positive pharmacological evaluation. A series N- (4- (benzo[d]thiazol-2-yl) phenyl)-2-[4-(aryl-substituted) piperazines-1-yl]acetamide, N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-[4-(arylsubstituted)piperazines-1-yl]acetamide and Synt...
SPECTROPHOTOMETRIC DETERMINATION OF DRUGS & PHARMACEUTICALS USING N-BROMOSUCCINIMIDE AND RHODAMINE-B COUPLE
Simple, sensitive, and accurate spectrophotometry method one each for estimation of five drugs viz., chloroquine phosphate (CHP), granisetron hydrochloride (GRA), rizatriptan benzoate (RIZ), zoledronic acid (ZOL) and zolmitriptan (ZOT), have been developed. The method depends upon oxidation of each drug by excess N-Bromo succinimide (NS), and subsequent determination of UN reacted NBS by Rhodami...
RP-HPLC METHOD QUANTITATIVE ESTIMATION OF TAPENTADOL HYDROCHLORIDE AND ITS TABLETS
The objective was to develop and validate an easy, economical, fast, reliable, reproducible, precise and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method for the estimation of tapentadol hydrochloride (TAP, a mu opioid-receptor agonist, and noradrenaline reuptake inhibitor) in the bulk and pharmaceutical dosage form. The chromatographic separation was achieved by u...
IN-VITRO ANTI-INFLAMMATORY ACTIVITY, ACUTE TOXICITY TO ZEBRAFISH EMBRYOS AND NUTRITIONAL ANALYSIS OF BOHADSCHIA VITIENSIS WATER EXTRACT
Anti-inflammatory activity and the toxicity of Bohadschia vitiensis water extract were investigated by in-vitro models to evaluate the consumption of the extract by the local community to reduce arthritic-related pain. Specimens of B. vitiensis were collected from Mannar, Sri Lanka, and the water extract (WE) was prepared by removing visceral organs and incubating diced samples in distilled water,...
EFFECT OF OLANZAPINE ON HYPERTHERMIA IN SEROTONIN SYNDROME MODEL
The serotonin syndrome is a life-threatening adverse drug reaction caused by a significant increase in the concentration of 5-hydroxytryptamine (serotonin) in the central nervous system. The aim of this study was to establish the effects of olanzapine, an antipsychotic drug, on the hyperthermic response in rat experimental serotonin syndrome. In this study, we used an animal model of the serotonin...
SYNTHESIS, SPECTRAL ELUCIDATION, ANTIBACTERIAL, ANTIOXIDANT AND DNA STUDIES OF ONNO TETRADENTATE SCHIFF BASE METAL(II) COMPLEXES DERIVED FROM 2-AMINOPHENOL DERIVATIVES
The new asymmetrical tetradentate (ONNO) Schiff base (L) 4-chloro- 2- ((E)- (4- ((E)-((2-hydroxy-5-nitrophenyl)imino)methyl)benzylidene) amino)phenol was prepared by the condensation of terephthalaldehyde with 2-amino 4-chlorophenol and 2-amino 4-nitrophenol in 1:1:1 molar ratio in methanol. The homo binuclear metal(II) complexes were synthesized in ligand to metal ratio 2:2 from the template meth...
PLANT MEDIATED GREEN SYNTHESIS OF SILVER NANOPARTICLES USING RUMEX OBTUSIFOLIUS LEAF EXTRACT AND THEIR ANTIBACTERIAL ACTIVITY
Rumex obtusifolius, belonging to the Polygonaceae family, commonly known as ‘broad-leaf-dock’ is one of the most important medicinal plants. It is common wayside weeds and uses as an antidote to nettle, depurative, astringent, laxative, and tonic and in the treatment of sores, blisters, jaundice, burns, cancer, and tumors. In this study, we design to synthesize silver nanoparticles from silver...
DEVELOPMENT OF RP-HPLC METHOD FOR THE ESTIMATION OF ACOTIAMIDE HYDROCHLORIDE HYDRATE USING AQbD APPROACH
The current studies details QbD enable the development of a simple, rapid, and cost-effective reverse phase high performance liquid chromatographic method for estimation of Acotiamide hydrochloride hydrate. The simple analytical RP-HPLC method was developed using Box-Behnken Design (BBD). In the present work, three independent factors were used, such as org phase (A), aqueous phase (B), and flow ...
PHYTONUTRIENTS AND ANTIMICROBIAL ASSAY OF CAT’S TAIL
Herbal medicine plays an important role in rural areas, and various locally produced drugs are still being used as household remedies for different ailments. Acalypha hispida (Euphorbiaceae) is a plant popularly used in pharmaceutical used and as a commercial product. Hence, the need to explore the potential of this plant, especially in the area of traditional medicine and pharmaceutical industrie...
IN-VIVO AND STABILITY STUDIES OF DRY POWDER INSUFFLATION CONTAINING TERBUTALINE SULPHATE AND ITRACONAZOLE NANOPARTICLES FOR THE TREATMENT OF ASTHMA
The present research was envisaged on the development of dry powder to treat asthma. Terbutaline sulphate (a bronchodilator) and Itraconazole (an antifungal) were used in the present study for bronchodilation and allergy to Aspergillus fumigatus (fungi) using lactose and trehalose as excipients. Dry powder insufflations were prepared by physical mixing (milling) and spray drying, out of which spra...
BIOSYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF SILVER NANOPARTICLES USING METHANOLIC EXTRACT OF BULB OF ZEPHYRANTHES CITRINA
In the present study, an eco-friendly, cost-efficient, rapid and simple approach was applied to the synthesis of silver nanoparticles by using a methanolic extract of bulb of Zephyranthes citrina. The metal salt was reduced to ions by metabolites present in bulb extracts. The plant extracts acts both as a reducing agent as well as a capping agent. The synthesized silver nanoparticles were characte...
A VALIDATED LCMS METHOD FOR THE ANALYSIS OF ISOPROTERENOL – A β ADRENORECEPTOR AGONIST IN SPIKED HUMAN PLASMA
A simple, sensitive, and rapid Liquid Chromatography-Mass Spectroscopy method was developed and validated for the quantification of Isoproterenol in human plasma using Dobutamine as an internal standard. The method utilized simple liquid-liquid extraction using a mixture of diethyl ether and dichloromethane for the sample preparation involved prior to LCMS analysis. The analytes were chromatograph...
EXPLORATION OF THE UNIQUE FUNGAL ASSOCIATION AND PROTEIN PROFILE OF BODA FROM BASTAR, CHHATTISGARH, INDIA
Bastar is endowed with a unique blend of traditional knowledge and rich floral diversity. The region is known as the island of Shorea robusta, which is a key source for white and black truffle called Boda. It is also known as the black gold of the sal forest. It sets underground with the onset of early monsoon and is an edible mushroom with high protein, vitamin, and fiber with the low calorific v...
DEVELOPMENT AND EVALUATION OF TRANSDERMAL DRUG DELIVERY OF SALBUTAMOL SULPHATE VIA ETHOSOMES
Asthma is a chronic disease; there is a need for a drug delivery system that maintains adequate therapeutic concentrations for a longer duration of action to improve better clinical efficacy. Salbutamol sulphate (SS) is a widely prescribed drug to treat asthma though it has short plasma half-life and undergoes extensive first-pass metabolism. Thus, it necessitates frequent administration by oral r...
IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM RHIZOPHORA MUCRONATA METHANOLIC LEAF EXTRACT BY GC-MS ANALYSIS
Herbal medicines play an important role in cancer prevention. Mangroves have been used worldwide due to the presence of various bioactive metabolites in it. The specific medicinal properties of Rhizophora mucronata have been an interest in preventing breast cancer. Mangroves Rhizophora mucronata belongs to family Rhizophoraceae. The leaf extract reveals various roles in folk remedies to treat vari...
HYDROPHILIC AND HYDROPHOBIC MATRIX SYSTEM ENGINEERED DEVELOPMENT OF EXTENDED-RELEASE TABLETS OF OXYBUTYNIN CHLORIDE
The present aim study is the formulation development and evaluation of extended-release matrix tablets of oxybutynin chloride by using hydrophilic and hydrophobic matrix systems. The pilot-scale batches of nine formulations were prepared using Eudragit RSPO, Eudragit RLPO, Carbopol 971NF, ethylcellulose individually, and in the combination of above polymer and Avicel PH102 by adopting direct compr...
EFFECT OF ABIOTIC STRESSES ON THE MARKER CONTENT AND THE ACTIVITY OF CENTELLA ASIATICA
Centella asiatica (CA; family Apiaceae) is extensively used in traditional medicine. A regular supply of this plant is required by the herbal drug industry. Hence, the cultivation of this plant is required. The emphasis of the available cultivation practices is on biomass yield. The activity of the plant, however, depends on the amount of bioactive constituents. The production of these secondary m...
DEVELOPMENT AND VALIDATION OF A CHROMATOGRAPHIC ASSAY METHOD FOR THE DETERMINATION OF LULICONAZOLE IN CREAMS
A simple and rapid reverse-phase high-performance liquid chromatographic technique was developed and validated for the determination of Luliconazole in the presence of its excipients. Chromatographic elution was performed on a binary gradient HPLC equipped with PDA detector using a Luna-5µ C8(2) 100 Å column (250 × 4.6 mm, 5 µm) with orthophosphoric acid (0.1%) and methanol (20:80% w/v) as mob...
UTILITY AND EFFECTIVENESS OF GENEXPERT OVER CONVENTIONAL METHODS FOR DIAGNOSIS OF PULMONARY TUBERCULOSIS
Background: Tuberculosis (TB) is a global health burden and can cause potential infection in any system of the body. Pulmonary tuberculosis (PTB) is most common presentation, but the diagnosis of TB remains elusive because of none of biochemical or serological test is invalid. During the development of END TB strategy, the gene expert (CBNAAT) test was first endorsed by WHO. Materials and Methods:...
PREFORMULATION, FORMULATION DEVELOPMENT AND DRUG RELEASE STUDIES OF DIPYRIDAMOLE FLOATING MICROBALLOONS
For the drugs possessing stomach and upper intestine as the absorption window, it has become high practical importance to improve their gastric residence time. The in vitro performance of the drug delivery being highly variable is ascertaining as gastric emptying is one of the complex mechanisms. Intense researches are being carried out for the development of multiparticulate systems, which are of...
A COMPARATIVE STUDY ON PROXIMATE AND MINERAL COMPOSITION OF UNPROCESSED AND PROCESSED UNDERUTILIZED JERUSALEM ARTICHOKE TUBER FLOUR
Jerusalem artichoke is one of the underutilized tuber crops distributed worldwide in temperate areas. It is considered healthy and functional food due to its chemical composition as it contains proteins, mono or poly-unsaturated fatty acids, dietary fibers, vitamins, and minerals. In this present research work, the effect of processing on the proximate and mineral composition of Jerusalem artichok...
DEVELOPMENT, CHARACTERIZATION AND OPTIMIZATION OF KUTKI PHOSPHOLIPID COMPLEX USING CENTRAL COMPOSITE DESIGN AND RESPONSE SURFACE METHODOLOGY
Kutki (Picrorrhiza kurroa) is a medicinal herb with remarkable pharmacological properties. However, poor solubility of the active principles limits its medicinal value. This study sought to prepare kutki phospholipid complex in phospholipids such as phosphatidyl choline in order to improve its solubility and permeability. Kutki phospholipid complex (phytosome) was prepared by solvent evaporation m...
DEVELOPMENT, OPTIMISATION, AND CHARACTERISATION OF SNEDDS OF ANTI-LIPASE INHIBITOR
Background: Self-Nanoemulsifying Drug Delivery System (SNEDDS) has been employed extensively by the formulation of scientists to tackle the low solubility issues of various drugs and lift the bioavailability profile. But the potential of SNEDDS is not limited to augment the dissolution profile only. Objective: The objective of the study was to develop, optimization, and characterization of SNEDDS ...
FORMULATION AND EVALUATION OF BILAYER FLOATING TABLETS OF ATORVASTATIN AND CAPTOPRIL
The aim of the present research work was to develop a bilayer floating dosage form of immediate-release Atorvastatin (ATR) and sustained release Captopril (CPT) in matrix form for the treatment of hyperlipidaemia and hypertension to reduce multiple dosing frequencies and enhance patient compliance. ATR belongs to the BCS Class II category having poor aqueous solubility, which was enhanced by using...
DEVELOPMENT AND CHARACTERIZATION OF CARBOXYMETHYLCELLULOSE BASED EMULGEL FOR DRY EYE SYNDROME
Dry Eye Syndrome is a common disorder of the normal tear film that results from one of the following: decreased tear production, excessive tear evaporation, an abnormality in the production of mucus or lipids normally found in the tear layer. Carboxymethylcellulose (CMC) is a highly viscous derivative of cellulose that is used as an eye lubricant. CMC moistens the eye to prevent or relieve dry eye...
MOLECULAR DOCKING STUDY OF ACYCLOVIR AND ITS DERIVATIVES AS POTENT INHIBITORS IN NOVEL COVID-19
Novel coronavirus (nCovid-19) is a recent emerging, dangerous pathogen that has shaken the whole world. Present therapeutic strategies to deals with this infectious disease are only supportive. The discovery of a new drug within a short period of time is a great task. Structure predictions of several proteins associated with SARS-CoV-2, the virus that causes COVID-19, was made possible by Genomics...
ASSOCIATION BETWEEN HYPERURICEMIA, SERUM IRON LEVEL AND POSSIBILITY OF GOUT AMONG SAUDI PATIENTS: A RETROSPECTIVE STUDY
The present study has been undertaken to evaluate the association between serum uric acid levels as a marker of iron overload in Saudi people. A retrospective cohort study was carried out at King Fahad Medical City in the Riyadh-central region of the Kingdom of Saudi Arabia for four months from 1st November 2018 to the end of February 2019 on the random sample of 117 medical files for Saudi patien...