Volume 13 (2022) - Issue 9, September
CONCERNS AND LIMITATIONS OF MATERIALS FOR ORAL DELIVERY OF INSULIN
Insulin is commonly administered to diabetic patients sub-cutaneously and has shown poor patient compliance. The problem lies with the delivery of proteins and peptides to the body, for which oral, transdermal, vaginal, rectal, and pulmonary routes have been explored for proteins like insulin. Still, so far subcutaneous route has delivered the best results. This results in fear of the patients due...
PLANT DERIVED ANTICANCER AGENTS FOR THE TREATMENT OF CANCER
Cancer is defined as a condition where cancerous cells multiply out of control in the body. It severely affects the human population on a global basis. New therapies are constantly needed to prevent and treat this life-threatening disease. Natural-derived compounds are attracting scientific and research interest due to their substantially fewer side effects than the current cancer treatment. Plant...
RHEUMATOID ARTHRITIS: AN UPDATE ON DIAGNOSTIC MODALITIES AND TREATMENT PROTOCOLS
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that permanently damages and disables the joints if left untreated. Much research is being carried out; however, any detailed information that could impart knowledge of all the major aspects in an undivided form is still lacking. This review attempts to revive the existing knowledge on RA and provides comprehensive data and cu...
NUTRACEUTICAL APPROACH TO NON-ALCOHOLIC FATTY LIVER DISEASE: A REVIEW
Nutraceutical is employed to explain a medicinal or nutritional component with a food, plant, or natural material that will be purified or concentrated. It is used to improve health by preventing or treating disease. Non-alcoholic fatty liver disease (NAFLD) is a clinical condition characterized by lipid infiltration of the liver with a high prevalence in the general population affecting 25% of ad...
A COMPREHENSIVE REVIEW OF PHARMACOLOGICAL PROPERTIES OF LITSEA POLYANTHA
Litsea, an outsized genus comprising 400 species of evergreen trees or shrubs, distributed chiefly in tropical and subtropical Asia, Australia, and therefore the Pacific Islands, belongs to the Lauraceae. Litsea polyantha is found throughout North, East, and Central India at an altitude of 1,200 m. It is often planted as an ornamental plant. It is mostly grown as an honest source of fodder for the...
PHYTOMEDICINES FOR COVID-19: OPPORTUNITIES AND OBSTACLES
COVID-19 is a disease caused by SARS-CoV-2 that can trigger respiratory tract infection. Due to its tendency to affect the upper respiratory tract (sinuses, nose and throat) or lower respiratory tract (windpipe and lungs), this disease is life-threatening and affects a large number of populations. This virus's unique and complex nature enhances the scope to look into the direction of herbal plants...
REVIEW ON IMPORTANCE AND BENEFITS OF EATING DATES IN WEAKNESS AND TREATING MENTAL HEALTH
Dates commonly known to be khajur in urdu (Phoenix dactylifera L.). Dates fruit is one of the best foods which possesses immense nutritional values. Date flesh is low in fat and protein but rich in sugars, mainly fructose and glucose Date have low cholesterol level and contains very little fat. It consists of proteins and various kinds of vitamins such as B1, B2, B3, and B5, and A1 and C. Date ar...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TERTIARY COMBINATIONS OF ANTIHYPERTENSIVE DRUGS: A REVIEW
The most important risk factor for cardiovascular disease is high blood pressure, which accounts for around one-third of those who have it. A majority of those who have hypertension are not on antihypertensive medication. It is not a disease, but it is an important risk factor for cardiovascular disease. Hypertension includes the intricate exchange of natural and pathophysiological factors that in...
TRIUMFETTA RHOMBOIDEA: A REVIEW ON ITS PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE
Triumfetta rhomboidea, often known as diamond burbark or Chinese bur, is a member of the Tiliaceae family. The plant is known as a weed, but a number of medicinal properties have been reported for its different parts. It is a tropical and subtropical shrub that can be found in India, Ceylon, the Malay Peninsula, China, Africa, and America. According to phytochemical analysis, it contains carbohydr...
3D PRINTING TECHNOLOGIES – AN OVERVIEW
3D printing is an emerging technological advancement that could be applied in several medical fields, the educational arena, and preoperative planning. 3D printing technology, also known as additive manufacturing, is significant as it is cost-effective compared to traditional cadaveric models. The purpose of writing the current review on 3D printing techniques was to compile the recent literature ...
IMPORTANCE OF DRUG EXCIPIENT COMPATIBILITY STUDIES BY USING OR UTILIZING OR EMPLOYING VARIOUS ANALYTICAL TECHNIQUES – AN OVERVIEW
The interaction/incompatibility of drug excipients is a major concern in formulation generation. Compatibility tests for drug excipients constitute an important step of the production of all dosage forms in the preparation stage. The possible physical and chemical interactions of drugs and excipients can influence chemical, physical, therapeutic properties and the dosage form's stability. The curr...
A POTENTIAL ROLE OF STEREOSPERMUM SUAVEOLENS DC FOR MULTIPLE DISEASES: A BRIEF ANALYSIS
As a source of medicine, plants have always been exceptional. Ayurveda and other Indian texts discuss the use of plants to treat a variety of human illnesses, including cancer and diabetes. Thousands of plant species in India, which number in the tens of thousands, are thought to have medicinal use. Recent studies on plants described in historical writings or used to treat sickness have been carri...
IN-SILICO ASSESSMENT VIA MOLECULAR DOCKING AND ADMET PROFILE OF BOTANICAL DRUGS (BERGAMOTTIN AND CASTICIN) AGAINST TRIAL DRUGS FOR LASSA VIRUS
Lassa fever is a serious viral haemorrhagic illness caused by Lassa virus, a family of Arenaviridae. This haemorrhagic fever has become rampant in West Africa especially in Sierra Leone, the Republic of Guinea, Liberia and Nigeria, through exposure to food or household items contaminated with urine or faeces of infected Mastomys rats. There has been no vaccines or particular antiviral agents/drugs...
EVALUATION OF THE ANTI-ARTHRITIC POTENTIAL OF SALIX ALBA IN EXPERIMENTAL RATS
Arthritis is a joint disorder which is characterized by inflammation. A joint function to move the body parts connected by its bones. Arthritis means inflammation of one or more joints. The study investigates the anti-arthritic activity in rodents by use of in-vivo parameters Paw volume, Knee diameter, Paw thickness, Paw oedema, and body weight. Some biochemical parameters were also done, such as ...
FORMULATION AND EVALUATION OF MUCOADHESIVE MATRIX TABLET OF ACYCLOVIR
The binding capacity of mucoadhesive polymers with gastric mucin prolongs the gastric residence time, increasing bioavailability. In the present research work, an attempt was made to formulate and evaluate sustain release mucoadhesive matrix tablet of Acyclovir. In the present work, an effort has been made to evaluate the effect of mucoadhesive polymers on the release characteristics of mucoadhesi...
TELMISARTAN NIOSOMES DESIGN, DEVELOPMENT AND CHARACTERIZATION
Telmisartan has a strong, nonpeptide antagonist with long-acting angiotensin II type-1 (AT 1) receptor to treat essential hypertension. It is classified as a BCS class II medication, meaning it has poor solubility and high permeability. Because of their capacity to minimise toxicity and change bioavailability, niosomes are becoming increasingly essential in medication delivery. Telmisartan-loaded...
SYNTHESIS OF 4- (4-SUBSTITUTED)-1-(3- SUBSTITUTED- 5, 6-DIHYDRO- [1, 2, 4] TRIAZOLO [3, 4-A] PHTHALAZIN-6-YLAMINO) AZETIDIN-2-ONE DERIVATIVES AS ANTIDIABETIC AGENTS
In this research work, numerous molecules that have substituted triazole phthalazine derivatives were obtained using phthalic anhydride as a starting material. It was taken as starting material that gave reaction in the precence of different conditions with different substituted benzoyl chloride that yielded 6 chloro-3 substituted 6a, 10 a-dihydro-[1, 2, 4] triazolo [3, 4-a] phthalazine derivati...
MORINGA OLEIFERA (MO) SEED CATALYZED THE SYNTHESIS OF BENZIMIDAZOLE DERIVATIVES
A simple, one-pot, and efficient method for the synthesis of benzimidazole derivatives via the condensation of o-phenylenediamine and substituted aromatic aldehydes in the presence of Moringa oleifera (MO) seed extract acts as a biocatalyst under microwave irradiation. The method provides several advantages such as simple operation, clean reaction ways, and high to the excellent yield of product. ...
POTENTIAL EFFECT OF HIGH CONSUMPTION OF ARTIFICIAL SWEETENERS ON GLUCOSE HOMEOSTASIS AND COMPLETE BLOOD COUNT IN MALE ALBINO RATS
Background: Artificial sweeteners are well-known today because of their high sweetness property with low or no caloric intake. However, consuming artificial sweeteners interferes with normal physiological processes within our bodies. Objectives: The study investigates biochemical changes in blood glucose homeostasis and hematocrit parameters during and after terminating intakes of aspartame and su...
A COMPARATIVE EVALUATION OF EFFICACY OF OBETICHOLIC ACID VS. URSODEOXYCHOLIC ACID IN PATIENTS WITH ACUTE VIRAL HEPATITIS
Background: Acute viral hepatitis (AVH) is a major public health problem. There is no specific treatment to attenuate AVH. The potential for adding bile acid in the treatment of AVH is consistently increasing. The objective of this study was to assess the effect of obeticholic acid (OCA) in treating AVH patients and also to compare its efficacy with ursodeoxycholic acid (UDCA). Methods: A prospect...
DEVELOPMENT AND EVALUATION OF FAST-DISSOLVING TABLETS OF AN ANTI-GOUT DRUG BY SUBLIMATION METHOD
The purpose of the current research was to formulate and evaluate patient-friendly allopurinol solid dispersion based fast-dissolving tablets using a sublimation technique in order to accomplish rapid drug dissolution. In the present study, an effort was made to fasten the release of allopurinol from oral tablet dosage form by the conversion of the drug into solid dispersion form followed by furth...
ANTIMICROBIAL ACTIVITY OF STEM BARK EXTRACT OF MANGIFERA INDICA AGAINST STAPHYLOCOCCUS SPECIES AND FREQUENCY OF USE OF ORGANIC EXTRACTS AS SKINCARE PRODUCTS IN COMMON POPULATION
Antimicrobial activity of stem bark of Mangifera indica was determined using the disk diffusion method to determine the susceptibility or resistivity of Staphylococcus species to the plant extract. Ethanol extract showed the highest inhibition zone diameter of 34mm, while the aqueous extract showed a zone diameter of 23 mm. The ethanol proved to be a better solvent, and the Staphylococcus species ...
ASSESSMENT OF DRUG USE PATTERN OF ANTIMICROBIALS AMONG PAEDIATRIC IN-PATIENTS OF TERTIARY CARE TEACHING HOSPITAL
Objective: This study gives an overview of prescribing pattern of antibiotics in children in our tertiary care teaching hospital. Methods: It is a prospective observational study carried out on paediatric in-patients with a sample of 160 patients based on age, inclusion, and exclusion criteria for a period of 6 months. The patient’s data were collected using a patient case record form and the da...
KNOWLEDGE, ATTITUDE AND PRACTICE OF NON-PHARMACOLOGICAL INTERVENTIONS IN SUBJECTS WITH CHRONIC NEUROPATHIC PAIN ON TARGETED PHARMACOLOGICAL THERAPY
Neuropathic pain (NP) is a chronic debilitating condition that affects all dimensions of health. Though pharmacological therapy is the main treatment of varied neuropathic pain conditions, not all neuropathic pain conditions respond well to drug therapies. Therefore, under-utilized non-pharmacological strategies were tried and implemented in chronic neuropathic pain subjects to provide adequate pa...
IN-VITRO ANTI-DIABETIC, ANTIOXIDANT AND ANTI-APOPTOTIC EFFECTS OF SELECTED INDIAN MEDICINAL PLANTS USING RINM5F CELLS
The major pathogenic mechanisms of diabetes are chronic hyperglycemia and glucotoxicity. Excess production of reactive oxygen species due to hyperglycemia results in oxidative stress and changes in mitochondrial energy metabolism promote β cell dysfunction, eventually leading to apoptosis and the development of diabetic complications. Although several oral antihyperglycemic agents are available, ...
DESIGN IN-SILICO MULTIPATHOGENIC VACCINE OF DENGUE AND ZIKA VIRUSES USING ENVELOPE PROTEIN
The Flaviviridae family of viruses includes the dengue virus (DENV) and the Zika virus (ZIKV). Which have already caused outbreaks and epidemics in a number of countries in the entire world. Dengue fever and Zika fever are two and among the most widely disseminated mosquito-borne viral illnesses in the world both of these diseases have the potential to erupt in many places of the world at the same...
IN-SILICO ANALYSIS OF SOME PHYTOCHEMICALS AS POTENTIAL THERAPEUTIC INHIBITORS AGAINST BREAST CANCER
Breast cancer continues to pose a serious hazard to women worldwide. (EGFR) was one of the first key targets for these new anticancer drugs to be discovered. Triple-negative breast cancer affects almost half of all women in the World. This study focused on the phytochemicals from a medicinal plant Clitoria ternatea; these medicinal plants possess more phytochemical compounds that effectively fight...
QUALITY OF LIFE-RELATED TO WORK PRODUCTIVITY AND PHYSICAL FUNCTIONING IN MIGRAINE PATIENTS: A SYSTEMATIC REVIEW AND NETWORK-META ANALYSIS
Background: Migraine is one of the major causes of disability affecting the productivity, physical, psychological and social well-being of patients. To conduct a systematic review and network meta-analysis (NMA) of randomized trials investigating the effect of anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) on productivity and physical functioning of adults migraineurs....
ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF CRUDE FLAVONOID FRACTION OF MITRAGYNA PARVIFOLIA
Inflammation is considered a primary physiologic defense mechanism that helps the body to protect itself against infection, burn, toxic chemicals, allergens, or other noxious stimuli. Inflammatory diseases are currently treated with steroidal and non-steroidal anti-inflammatory drugs (NSAIDs). Unfortunately, both of these widely prescribed drug classes have significant negative side effects. Hence...
PRONIOSOMES-ENCAPSULATED DEXKETOPROFEN TROMETAMOL, FORMULATION, OPTIMIZATION, CHARACTERIZATION WITH IMPROVED DRUG RELEASE
Photodermatitis had been defined within the literature after using oral dexketoprofen and different facet results as NSAIDs are also harmful for the liver. So, to triumph over such risky results, this molecule has been encapsulated with the assistance of non-ionic surfactants. Current studies supported the occasion and differentiation of transdermal proniosome-primarily based gel. The preformulati...
IN-VITRO SCREENING OF EXTRACTS OF CENTELLA ASIATICA (LINN) URBAN FOR ANTIBACTERIAL PROPERTIES
Centella asiatica (Linn) Urban, a herb of immense medicinal properties, has been widely used by traditional healers in the treatment of skin diseases, mental fatigue, anxiety, rheumatism, eoilepsy and leprosy. In the present investigation, the antibacterial activity of ethanol, acetone and aqueous extracts of Centella asiatica were tested in-vitro against seven bacterial species viz. Staphylococcu...
FREE RADICAL SCAVENGING ACTIVITY OF VARIOUS EXTRACTS OF ANISOMELES MALABARICA (L)
The present study aimed to determine the antioxidant potential of different solvent extracts of A. malabarica. Drug discovery from traditional medicinal herbs has played a significant role in the therapeutic management of cancer and, undoubtedly, most novel clinical applications of medicinal plants and its secondary metabolites and derivatives. The leaves extract showed various folklore and tradit...
AN ECO-FRIENDLY HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ABACAVIR, DOLUTEGRAVIR AND LAMIVUDINE IN ACTIVE PHARMACEUTICAL INGREDIENTS AND MARKETED TABLET FORMULATION
Selective and novel method has been optimized to evaluate Abacavir, Dolutegravir and Lamivudinein bulk and formulation by HPLC. The principle analytes were eluted with the conditions of the mobile phase having the Ethanol: Ethyl acetate (80:20, % v/v) using the Lichrosphere RP C8 column (Phenomenex, USA (250 x 4.6 mm, 5μ) analytical column with the 1.0 ml/min flow rate and 10µl sample volume at...
DESIGN OF EXPERIMENT (DOE) APPROACH FOR A SIMPLER HPLC TECHNIQUE ESTIMATING THYMOQUINONE FROM NIGELLA SATIVA SEEDS, COMMERCIAL FORMULATION, POLYMERIC NANOPARTICLES, AND ITS STABILITY INDICATION
To the best of our knowledge, the factorial design methodology has never been used to estimate Thymoquinone (TQ) using the reverse phase High-Performance Liquid Chromatography (RP-HPLC) method, making our work unique. The study aimed to create, verify and validate a simple stability-indicating analytical technique for quantitative detection of TQ in Ayurvedic formulations, black seed and polymeric...
COMPARING THE EFFICACY AND PHARMACOECONOMICS OF ATORVASTATIN AND ROSUVASTATIN
The aim of the research work was to determine and compare the efficacy and pharmacoeconomics of Atorvastatin and Rosuvastatin. The cohort, observational, and prospective studies were conducted at KMC multispeciality hospital, Trichy. The hyperlipidemic patient was treated with Atorvastain (10 mg) and Rosuvastatin (5 mg) every day over a period of six months. Contemplating the inclusion and exclusi...
INVESTIGATION OF IGF-1 SERUM LEVELS IN HEALTHY CHILDREN DURING SYRIAN CONFLICTS
Purpose: Insulin-like growth factor-1(IGF-1) is an important growth hormone that promotes the anabolic effect and linear growth in adults and children. This study aimed to assess serum levels of IGF-1 in healthy Syrian children during Syrian conflicts. Materials and Methods: This study was approved by Al Wataniya Private University ethical committee. In total, 83 children, 49 males and 34 females ...
AN IN-VIVO STUDY TO EVALUATE THE ANTI-ULCER ACTIVITY OF NĀRIKELĀ LAVANA IN PYLORIC LIGATION INDUCED ULCER IN WISTAR ALBINO RATS
Lavana kalpanas are pharmaceutical preparation in which the ‘Lavana’ and the selected ‘auṣadhadravyā’ are igniting together in a closed sampuṭā to obtain the drug ash as medicinal product. Nārikelā lavana, one among the lavana kalpana mentioned in Bhaiṣajyaratnāvali 30th chapter and in Rasa taraṇgiṇi14th chapter. Nārikelā lavaṇa proved to have a high amount of electrolyt...
DEGREDATION OF PERCHLORATE WITH PHENOL AS A SOLE CARBON SOURCE BY AN ISOLATED STRAIN PSEUDOXANTHOMONAS SP.
Phenol was used as a sole carbon source for the perchlorate biodegradation as reported for the first time. Isolated bacterial species Pseudoxanthomonas sp. isolated from a sewage sludge consortium was found to reduce perchlorate while taking phenol as electron acceptor. The growth and perchlorate degradation were analyzed in a batch system along with the degradation profile of phenol by the microb...
STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF DORAVIRINE, LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE IN PHARMACEUTICAL DOSAGE FORM
Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate belong to the class of anti-viral drugs and have been widely used in the treatment of HIV-I infection. Doravirine is a novel non-nucleoside reverse transcriptase inhibitor used in the combination of Lamivudine and Tenofovir Disoproxil Fumarate to effectively treat HIV/AIDS by overcoming the common resistance mutations without any possible d...
ASSESSMENT OF CLINICAL AND DEMOGRAPHIC PROFILE OF AURICULAR LOBULOPLASTY: A STUDY OF 446 PATIENTS
Objectives: Ears are an important part in our facial aesthetics and cosmetics. Complete and partial ear cleft patients are routine in the ENT outpatient department for surgical repair. The objective of this study is to evaluate the surgical outcomes of auricular lobuloplasty. Methods: Total 446 patients who underwent auricular lobuloplasty were included in this study. Demographic characteristics, ...
EVALUATION OF HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY OF 50% HYDRO ETHANOLIC LEAF EXTRACT OF BARLERIA CRISTATA L. IN ALLOXAN INDUCED DIABETIC AND HIGH LIPID DIET FED RATS
The present study was carried out to evaluate the hypolipidemic and hypoglycemic effects of the plant Barleria cristata L. Phytochemical screening of crude powdered leaf extract of Barleria cristata L. revealed the presence of various bioactive phytoconstituents. An acute toxicity study of 50% hydroethanolic leaf extract of Barleria cristata L. reported that at all normal therapeutic doses, the te...
ANTIVIRAL POTENTIAL OF DESMODIUM GANGETICUM (L.) DC. EXTRACT: DEVELOPMENT OF ANTIVIRAL PHYTOMEDICINE (GANJHUVIRR) FOR THE TREATMENT OF DENGUE FEVER ASSOCIATED WITH THROMBOCYTOPENIA
Natural products can be the alternative of synthetic medicine and antiviral drugs can be potential from natural products. An attempt was made to evaluate the antiviral activity from the extract of Desmodium gangeticum (L.) DC. as a phytomedicine (GanjhuVirR) for the treatment of dengue fever associated with thrombocytopenia. The present study was evaluated acute and subacute toxicity in rat as wel...
HOME REMEDIES, DIETARY AND LIFESTYLE CHANGES DURING COVID-19 PANDEMIC
December 2019 has become one of the most surprising days in the whole world in light of the flare-up of a most infectious sickness brought about by novel Covid or Severe Acute Respiratory Syndrome Corona virus 2 (SARS-CoV-2). This study is conducted to assess the benefits of the use of home remedies to prevent the cause of Covid-19 and evaluate the assessment of dietary changes and physical activi...
ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE IN HYPERTENSIVE PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL
Background: In India, Hypertension is becoming more common and severe, and it is linked to various socio-demographic factors. Many people are ignorant of their illness's severity and the significance of managing it due to a lack of adequate support and education. The first step in developing a preventive program for any health condition is obtaining information regarding the level of awareness. O...
FLAVONOIDS AS POTENTIAL DRUG AGAINST POST-COVID-19 MUCORMYCOSIS: AN IN-SILICO STUDY
Covid-19 associated mucormycosis rose sharply during India’s 2nd wave of coronavirus infections. The administration of immunosuppressive drugs led to increased susceptibility of patients to oppurtunistic diseases like mucormycosis. One of the causative species of mucormycosis is Rhizopus microsporus. For this study, we choose two chalcones and examined their ability to act as potential anti-muco...
PREPARATION AND EVALUATION OF FLOATING MICRO BEADS FOR GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF ANTIULCER DRUG
The objective of the present investigation was to develop an alginate-HPMC K4M microbead-based gastro-retentive drug delivery system incorporating Famotidine for the treatment of gastrointestinal ulcers. The 32 full factorial designs were used for the optimization of famotidine-loaded floating microbeads. Two factors were evaluated, each at 3 levels; experimental trials were performed for all nine...