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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 4 (2013) - Issue 11, November

Review Articles

 
Title
Views
PDF
Cited
1.

GOLD NANOPARTICLES: PROMISING AND POTENTIAL NANOMATERIAL

Gold nanoparticles (AuNPs) have appeared as an attractive candidate for delivery of various drug molecules or considered as extraordinary molecular carriers for the targeting, intracellular trafficking and delivery of a huge array of biomolecules including DNA, RNA, proteins, peptides, drugs, genes and other molecules of therapeutic significance. Particularly gold nanoparticles have attracted inte...

Madhuri Shringirishi*, S.K. Prajapati , Alok Mahor , Shashi Alok , Poonam Yadav and Amita Verma

Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University , Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4068-82

4068-4082

1145

609

2.

AN OVERVIEW OF AZOLE ANTIFUNGALS

Fungal infections in critically ill or immunosuppressed patients were increasing in incidence in the human population over the last 1-2 decades. There were few advances in antifungal therapy and, until recently, there were few choices from which to select a treatment for systemic mycoses. However, in the past decade, there have been several developments in this area. Antifungal agents are sufficie...

Pratibha Shivaji Gavarkar*, Rahul Shivaji Adnaik, and Shrinivas Krishna Mohite

Rajararambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli- 415404, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4083-89

4083-4089

6750

872

3.

ANTIPLATELET THERAPY AND RESISTANCE: A MINI REVIEW

Arterial thrombus formation are due to  mainly platelet activation and aggregation  which are considered to be central to pathological changes occurring in the vessel leading to the various complications and mortality . Antiplatelet drugs are used to prevent and help in the reversal of platelet aggregation in arterial thrombosis which was the major culprit in the pathology of myocardial infarcti...

Pugazhenthan Thangaraju*, Harmanjit Singh , Amitava Chakrabarti and Hariharan Balasubramanian

Room No: 4012, Fourth Floor, Department of Pharmacology, Research Block B, Chuttani Block, PGIMER, Chandigarh- 160012, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4090-97

4090-4097

1695

588

4.

ULTRADEFORMABLE SYSTEM: A CARRIER FOR TRANSDERMAL DRUG DELIVERY

The delivery of therapeutic agents transdermally has received considerable interest because of the safety and convenience of drug administration via this route. Recently, various strategies have been used to augment the transdermal delivery of bioactives.  A transfersome is an artificial vesicle designed to be like a cell vesicle, and used to deliver drugs or genetic material into a cell. Transfe...

Deepika Singh

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences- Deemed University, Allahabad, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4098-04

4098-4104

2352

675

5.

CURRENT SCENARIO OF HERBAL TECHNOLOGY WORLD WIDE: AN OVERVIEW

This article addresses the basic concepts of herbal technology which is used worldwide. 21st century is the century of Biology mechanical and propelled by scientific knowledge and hi-tech expertise. Herbal technology, are going to be the most influential elements that are fundamental for success and welfare for the people of nations.Information on the herbal technologywas collected via electronic ...

Parul Agarwal*, Shashi Alok , Amreen Fatima and Amita Verma

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4105-17

4105-4117

5159

1889

6.

GUSTATORY SYSTEM AND MASKING THE TASTE OF BITTER HERBS

The oral route is the most easy and favorable route of drug administration. The development of oral formulations containing bitter herbs has widely been required in pharmaceutical and herbal industry. The human gustatory system is capable of identifying five major taste qualities: sweet, sour, salty, bitter and umami (savory). Different receptors and transduction mechanisms are involved in the det...

Vinita Kale, Chetan Tapre and Abhay Ittadwar

Department of Pharmaceutics, Gurunanak College of Pharmacy, Nagpur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4118-24

4118-4124

3091

829

7.

TRANSFEROSOME: LATEST UPDATES

Poor patient compliance is a frequent problem in daily clinical practice. The unfavorable pharmacokinetic of the drug, the inconveniences of the standard form of such drug application and the side effects due to the administration route often are the reasons for this. The high and self-optimizing deformability of typical composite transferosomes membrane, which are adaptable to ambient tress allow...

V. Dilip Kumar, B. Saraswathi and N. Prudvi Kanth

Trinity College of Pharmaceutical Sciences, Jangoan College of Pharmaceutical Sciences, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4125-32

4125-4132

2021

698

8.

SWALLOWABLE WIRELESS CAPSULAR ENDOSCOPY: A NOVEL BREAKTHROUGH IN THE BIOMEDICAL INDUSTRY AND FUTURE PROGRESS

Wireless capsule endoscopy (WCE) is a medical procedure which has revolutionized for the first time a painless inspection of the small intestine. It is a simple, safe, non-invasive, reliable technique, well accepted and tolerated by the patients, which allows complete exploration of the small intestine. WCE has vitamin size pill which captures images of the digestive tract and entire small bowel, ...

P.V. Waghmare*, C.V. Panchal and B.N. Poul

Department of Quality Assurance, Maharashtra College of Pharmacy, Nilanga, Dist. Latur- 413521, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4133-44

4133-4144

2229

490

9.

LIVER SPECIFIC DRUG TARGETING STRATEGIES: A REVIEW

Drug delivery to liver is one of the most challenging research areas in pharmaceutical sciences. The some physiological barrier such as opsonization, mechanical entrapment by pulmonary vascular bed, uptake by RES represents an insurmountable obstacle for a large number of proteins and drugs, including antibiotics, antineoplastic agents and antiviral agents to target liver disorders. Therefore, var...

Ramesh S. Gorad*, Satish K. Mandlik and Kishore N. Gujar

Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune-411 041, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4145-57

4145-4157

9870

1490

10.

TAHLAB (SPIRULINA) AND FEW OTHER MEDICINAL PLANTS HAVING ANTI-OXIDANT & IMMUNOMODULATORY PROPERTIES DESCRIBED IN UNANI MEDICINE – A REVIEW

Antioxidants are substances that may protect cells from the damage caused by unstable molecules known as free radicals; free radicals damage may lead to cancer and other diseases. Some of the example of antioxidants are like β-carotene, lycopene, Vit. C, E & A and other substances which are found in variety of fruits, vegetables, algae (spirulina) & other medicinal plants. Spirulina (Blue...

Md. Anzar Alam*, Nafis Haider , Shamim Ahmed , Md. Tanwir Alam , Abdul Azeez and Aisha Perveen

Md. Anzar Alam*1, Nafis Haider 2, Shamim Ahmed 3, Md. Tanwir Alam 4, Abdul Azeez 5 and Aisha Perveen 3

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4158-64

4158-4164

2764

839

11.

NANOCARRIERS: A NOVEL TREATMENT APPROACH FOR ARTHRITIS

Arthritis is a major cause of disability conventionally treated for long term with nonsteroidal anti-inflammatory drugs and corticosteroids. NSAIDs are nonselective inhibitors of cyclooxygenase and cause GI toxicity, antiplatelet effects, cardiotoxicity, renal toxicity and anaphylactic reactions in selected patients. Corticosteroids have multiple side effects, including gastrointestinal bleeding, ...

Prachi Pandey* and S.S Pancholi

Department of Pharmaceutics, Babaria Institute of Pharmacy, Varnama, 391240, Vadodara, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4165-74

4165-4174

1838

1077

12.

AN OVERVIEW ON VARIOUS MODIFICATIONS OF CHITOSAN AND IT’S APPLICATIONS

Chitosan is a natural polysaccharide which is widely exploited for its various applications. It has received much attention as a functional biopolymer especially in pharmaceutics and medicine because of its better biodegradability, biocompatibility, versatility and availability. The unique biological applications of chitosan are attributed to these specific properties. The chemical and biological ...

R. Rajasree and K.P. Rahate*

Amrita School of Pharmacy, Amrita Viswa Vidyapeetham University, AIMS Ponekkara P. O., Kochi – 682041, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4175-93

4175-4193

5672

1362

13.

EVIDENCE BASED ANTI-DEMENTING ACTIVITY OF SARASWATA GHRITA “A NOOTROPIC COMPOUND FROM AYURVEDA

Life expectancy is increasing as a result of advancement  in medical  science  and  the  availability  of  better  healthcare  services. As  the  risk  of  dementia  increases  with  increasing  age,  the  number  of  persons  with  dementia  in the general population is also rising. Alzheimer’s disease is the most common form of dementia, accounting for approximately 70%...

Obed Ahmed Ansari, J.S. Tripathi and Sayema Ansari

Division of Manas Chikitsa (Psychosomatic Medicine and Neuropsychiatry), Department of Kayachikitsa, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4194-02

4194-4202

3093

1142

14.

EXPRESSIONS PROFILING PROJECT OF HUMAN EMBRYONIC LUNG CELLSEXPOSED TO PYROLYZED CIGARETTE SMOKE

In contrast to the problematic health and economic effects of acute and chronic smoke exposure on lung function and airway inflammation, there are still few data dealing with the effects of smoking. Smoke exposurecan result in aberrant cell growth. In our experiments, pyrolyzed components of cigarettes have been shown to induce a strong stress response in cultured cells. We used human embryonic lu...

Klaus Braun*, Gabriele Müller , Matthias Schick , Melanie Bewerunge-Hudler , Oliver Heil , Manfred Wiessler , Rüdiger Pipkorn , Wolfhard Semmler and Waldemar Waldeck

Medical Physics in Radiology, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4203-22

4203-4222

1948

614

Research Articles

 
Title
Views
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Cited
15.

EVALUATION OF THROMBOLYTIC AND MEMBRANE STABILIZING ACTIVITIES OF FOUR MEDICINAL PLANTS OF BANGLADESH

The crude methanol extracts of aerial parts ofAbrus precatorius L., leaf of Magnolia pterocarpa Roxb. and Dracaena spicata Roxb. and leaf and bark ofRavenala madagascariensis Sonn. as well as their hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates were subjected to screenings for thrombolytic and membrane stabilizing activities. Among the extractives of A. precatorius, the...

S.R. Chowdhury, T. Sharmin*, M. Hoque, Md. Sumsujjaman, M. Das and F. Nahar

Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4223-27

4223-4227

1920

666

16.

LORNOXICAM SUPPOSITORIES: IN-VITRO FORMULATION AND IN-VIVO EVALUATION

The aim of the present study was to formulate lornoxicam into rectal suppositories as a new dosage form, to avoid its reported gastric irritation and to provide a rapid onset of action for children. Suppositories were prepared using fatty bases namely; witepsol H-15, suppocire AML, CM, witepsol E-75 and water soluble bases; mixtures of poly(ethylene glycol), PEGs, with different molecular weights....

Hesham M. Tawfeek

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4228-35

4228-4235

2099

1013

17.

APPLICATION OF LYSOZYME AND DEXTRAN CONJUGATED LYSOZYME AS NATURAL ANTIMICROBIAL AGENTS IN THE TREATMENT OF EXPERIMENTAL SKIN WOUND IN MICE

Background: Skin wound infected by Staphylococcus aureus (S. aureus) is a common and painful lesion. Tetracycline is commonly used as the antibiotic of choice for its treatment. Aim: to determine the effectiveness of hen egg white lysozyme and dextran conjugated lysozyme in decreasing the bacterial count of experimentally induced skin wound infection in mice. Methods; Lysozyme was conjugated...

A. Karachi , H. Rajaian , M. Aminlari M* and A. Tabatabaee

Medical Physics in Radiology, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4236-44

4236-4244

1913

766

18.

PHARMACOGNOSTICAL EVALUATION OF BOMBAX MALABARICUM LEAVES

In different parts of India, Bombax malabaricum (Family: Bombacaceae), is well known for its traditional use in inflammation, prolapse of uterus or vagina, menorrhoea, diarrhoea, wound etc. Literature survey showed that the leaves of Bombax malabaricum have anti-inflammatory, antipyretic, analgesic and antioxidant activities. Although the plant has much potentiality, proper pharmacognostical stand...

Emdad Hossain*, Subhash C. Mandal and Jayanta K. Gupta

Professor, Pharmacy College, Azamgarh 276128, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4245-52

4245-4252

1699

548

19.

ANTIBACTERIAL AND CYTOTOXIC ACTIVITIES OF THYMUS VULGARIS LEAVES GROWN IN OMAN

Thyme (Thymus vulgaris L.) is a pleasant smelling perennial shrub, which grows in several regions in the world. The plant is reported to have high economic and medicinal values. The objectives of this research was to determine antimicrobial activity of petroleum ether, chloroform and hydroalcoholic extracts obtained from leaves of Thymus vulgaris collected from Oman. The other objective was to det...

Aisha Haroon Al-Balushi, Maryam Aljabri, Md. Sohail Akhtar*, Sadri Said, Afaf Weli, Qasim Al-Riyami and Ahlam A. AlAbri

School of Pharmacy, College of Pharmacy and Nursing, University of Nizwa, Nizwa, Sultanate of Oman

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4253-57

4253-4257

1804

562

20.

METHOD DEVELOPMENT AND VALIDATION OF TULOBUTEROL IN API AND ITS PHARMACEUTICAL DOSAGE FORMS BY UV SPECTROPHOTOMETRY

A simple, accurate, sensitive and reproducible UV spectrophotometric method has been developed for the determination of Tulobuterol (TLB) in bulk and also in its pharmaceutical dosage formulations. The proposed method showed absorbance maxima at 212 nm. Beer's law is obeyed over a concentration range of 25-125µg/mL. The respective linear regression equation being Y =0.009x +0.014 for TLB. Results...

Y. Ravindra Reddy* and K.V.M. Krishana

Department of Pharmaceutical Analysis and Quality Assurance, Teegala Ram Reddy College of Pharmacy, # 4 – 202, Meerpet, Saroonagar (M), Hyderabad– 500097, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4258-62

4258-4262

1921

616

21.

PHYSICOCHEMICAL AND PHYTOCHEMICAL PROFILES OF AERIAL PARTS OF LIPPIA NODIFLORA L.

Lippia nodiflora L. is an important medicinal plant of Verbenaceae family and are used traditionally for several ailments. The present study deals with the detailed physicochemical, fluorescence and phytochemical evaluation of aerial parts of Lippia nodiflora L., in order to explore the authentic plant material suitably for its traditional claims. Thephysicochemical evaluations and fluorescence an...

A. Sudha and P. Srinivasan*

Department of Bioinformatics, Alagappa University, Karaikudi- 630 004, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4263-71

4263-4271

2315

1126

22.

QSAR AND PHARMACOPHORE MODELING BASED DRUG DESIGNING FOR SPLEEN TYROSINE KINASE (SYK) PROTEIN FOR HUMAN USING ACCELRYS DISCOVERY STUDIO SOFTWARE IN LINUX SERVER

From this current research, Syk (spleen tyrosine kinase) protein and gene information is analyzed by different genomics, proteomics tools & databases. One crystal ligand 4DFL was collected from protein data bank (pdb). From different literature review 131 syk protein inhibitors were collected. Molecular modeling of these 131 molecules was done through Accelrys discovery studio (ADS). Choose ap...

Kuldeep Sahu

Biocampus, GVK Biosciences Pvt. Ltd., Plot no-79, IDA Mallapur, Hyderabad-500 076, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4272-80

4272-4280

1938

742

23.

PARTIAL PURIFICATION OF LIPASE FROM STREPTOMYCES VARIABILIS NGP 3 AND ITS APPLICATION IN BIOREMEDIATION OF WASTE WATER

Partial purification and bioremediation of waste water by lipase from the marine actinomycete Streptomyces variabilis NGP 3 (Accession no: (JX843530)) were carried out. The optimum incubation period, pH, temperature and agitation speed for enzyme production were fifth day (61.2 U/ml), 9.0 - 9.5 (105 U/ml), 35ºC (39.4 U/ml) and 120 rpm (38.7 U/ml) respectively. Lactose (2.0 g/l) and peptone (0.6 a...

K. Selvam* and B. Vishnupriya

Department of Biotechnology, Dr. N. G. P. Arts and Science College, Coimbatore - 48, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4281-89

4281-4289

1614

886

24.

FORMULATION DEVLOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERE OF LOSARTAN POTASSIUM BY USING NATURAL POLYMER

The present work is regarding formulation, development and evaluation of losartan potassium microspheres using natural polymer. The mucoadhesive microspheres of losartan potassium were successfully developed by W/O emulsion solvent evaporation technique using two different natural polymers katira gum and babul gum. Total 12 batches were formulated. Six formulations were prepared by using each natu...

Sonali M. Khobragade* and Kanchan P. Upadhye

J.L. Chaturvedi College of Pharmacy, Electronic Building, Hingna Road, Nagpur- 440 016, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4290-02

4290-4302

1694

749

25.

SYNTHESIS OF 2, 6-DIAMINO-3-PHENYLAZOPYRIDINE-1-OXIDE AND ITS HYDRO-CHLORIDE

The compound 2, 6-diamino-3-phenylazopyridine hydrochloride salt is a genito-urinary antiseptic drug under the trade name Pyridinium. This study is directed towards the occurrence of an oxidation reaction to convert the tertiary amine present in 2, 6-diamino-3-phenylazopyridine hydrochloride to form an N-oxide derivative as an impurity in the process for its preparation. This was done by the indep...

Ganesh Babu Talagadadeevi, Ramakrishna Muvva, Bangar Reddy Vancha and Madhusudana Rao Jampani*

R&D Department, Posh Chemicals Pvt. Ltd. 86/C Phase-1 IDA, Jeedimetla, Hyderabad, 500055, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4303-07

4303-4307

1892

829

26.

OPTIMIZATION OF ULTRASOUND-ASSISTED EXTRACTION OF TOTAL FLAVONOIDS AND ANTIOXIDANT PROPERTIES FROM TRIGONELLA FOENUM-GRAECUM SEEDS WITH RESPONSE SURFACE METHODOLOGY

Trigonella foenum-graecum is an annual plant in the family Fabaceae. The distinctive cuboid-shaped, yellow to amber coloured fenugreek seeds are frequently encountered in the cuisines of the Indian subcontinent. In this study, Trigonella foenum-graecum is used as an experimental matrix. Ultrasound-assisted extraction (UAE) of total flavonoids from Trigonella foenum-graecum is studied with dua...

Shaileyee Das

Department of Pharmaceutical Chemistry, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus Kolkata group of Institution, Kolkata-700053, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4308-18

4308-4318

1565

550

27.

IN-VITRO STUDY OF ANTICONVULSANT ACTIVITY ON THE FRUITS EXTRACTS OF COCCINIA INDICA (WIGHT &ARN.) INDUCED MAXIMAL ELECTROSHOCK SEIZURE (MES) MODEL IN RATS

Aim of the study:In-vitro study of Anticonvulsant activity on the fruits extracts of Coccinia indica (Wight &Arn.) induced maximal electroshock seizure (MES) model in rats. Materials & methods:  For the assessment of anticonvulsant activity, the animals were divided into five groups of five animals each albino rats. Group I received Normal saline, Group II received Phenytoin, Group III...

Mayank Kumar*, Shashi Alok , Sanjay Kumar Jain and Amita Verma

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4319-24

4319-4324

1628

767

28.

EVALUATION OF ANTIDIABETIC POTENTIAL OF METHANOLIC EXTRACT OF COCCINIA INDICA LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Coccinia indica is a climbing, herbaceous, branched tropical vine native to tropical Asia, including India. Being a part of Indian traditional medicine for ages, it has been widely used in reducing blood sugar among various other uses. The primary objective of this study was to investigate the reported anti-diabetic potential of methanolic polyherbal extract of Coccinia indica leaves in streptozot...

Saikat Ghosh* and Tanushree Roy

Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4325-28

4325-4328

1819

728

29.

COMPARATIVE IN VITRO DRUG RELEASE STUDIES OF GLIMEPIRIDE SOLID DISPERSIONS & METFORMIN MICROCAPSULES

The study was undertaken to compare the efficacy and safety of Glimepiride and Metformin in the management of patients with type 2 DM. The present invention is directed to a pharmaceutical composition in the form of a capsule with increased bioavailability as well as the process for obtaining said composition. The tablet of the present invention comprises two active ingredients comprising two oral...

B.V. Ramana*, D.S. Spandana Anand P, C. Triveni, V. Pavan Kumar, P. Venkateshwar Reddy and U. Chandra Sekhar

Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool- 518 002, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4329-35

4329-4335

1828

547

30.

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2-(4-FLUORO BENZYLTHIO)-N-(SUBSTITUTED PHENYL)PYRIMIDINE-4-AMINES

Reaction of 4-fluorobenzylchloride with 2-thiouracil (1) gave 2-(4-fluorobenzylthio)pyrimidin-4(3H)-one (2), which on chlorination with POCl3 furnished 4-chloro-2-(4-fluorobenzylthio)-4-chloropyrimidine (3). This intermediate when treated with various substituted anilines gave desired targeted compounds 4(a-k) in 50-90% yield. Structural assignments of the synthesized compounds were based on their...

N.M. Goudgaon*, Y. Rohini Reddy and B.U. Sheshikant

Department of Post Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga - 585106, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4336-42

4336-4342

1338

472

31.

RP-HPLC METHOD FOR THE ESTIMATION OF TAMSULOSIN AND SOLIFENACIN IN BULK AND ITS DOSAGE FORMS

A liquid chromatographic method has been developed and validated for the determination of the clinical trial combination of Solifenacin succinate and Tamsulosin hydrochloride. Effective chromatographic separation was achieved on an eclipse XDB-C18 (4.6 mm X 150 mm, 5µm) column using isocratic reverse phase technique. The mobile phase employed was ACN: 20Mm sodium phosphate buffer (0.2% Triethylam...

D. Samson Israel*, K. Krishnachaitanya, D. GowriSankar

University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4343-50

4343-4350

2328

1703

32.

FORMULATION & OPTIMIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF SIMVASTATIN USING RESPONSE SURFACE METHODOLOGY

The aim of the work is to formulate sustained release matrix tablets of simvastatin and to optimize them using Response Surface Methodology. The tablets were prepared by direct compression method and evaluated as per pharmacopoeia methodology. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profile. Concentration of HPMC K15M (X1) and ...

Disha Kesharwani*, Gunjan Kalyani , Anchal Verma , Priyanka Dewangan , Shailendra P. Kela and Chandra Patro

Royal College of Pharmacy, Raipur, Chhattisgarh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4351-61

4351-4361

2303

764

33.

EFFECT OF CEFIXIME ON PHARMACOKINETICS OF NEBIVOLOL IN HYPERTENSIVE PATIENTS

The present study was carried out to assess the pharmacokinetic drug interaction between nebivolol and cefixime following single oral dose administration in hypertensive patients. Therapeutic dose of nebivolol alone and combination with cefixime were administered to a separate group of hypertensive patients. Serial blood samples were collected at pre-dose (0.0) to 48 h post-dose following each tre...

B. Venkateswarlu*, D. Jayaprakash , Ravindernath Anisetti , N. Narsaiah and M. Ravindra Reddy

Administration, KarimNagar, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4362-65

4362-4365

2069

509

34.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF MARAVIROC IN BULK AND PHARMACEUTICAL FORMULATION BY UV SPECTROSCOPY

The aim of present work is to develop and validate simple, sensitive, economical and accurate Spectrophotometric methodhas been developed for determination of Maraviroc in pure form and in pharmaceutical formulations. Maraviroc in Phosphate buffer pH 7.4 shows maximum absorbance at 210 nm. Beer’s law was obeyed in the concentration range of 5-25 µg/mL, The LOD and LOQ were found to ...

Sellappan Velmurugan* and Mohamed Ashraf Ali

Department of Pharmaceutics, Sunrise University, Alwar, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4366-70

4366-4370

1844

834

35.

SYNTHESIS OF N-(ALKYL OR ARYL)-2-(1H-BENZOTRIAZOL-1-YL)-ACETAMIDES AS SELECTIVE COX-2 INHIBITOR

Microwave assisted organic synthesis (MAOS) has emerged as frontier in pharmaceutical research for synthesis of newer drugs and implementing GREEN chemistry. Arylacetamides are pharmaceutically interesting as they show various biological activities such as analgesic, local anesthetic, antiarthritic, antiarrhythmic activities, etc. In arylacetamides the nature of aromatic ring and its substituent i...

Amruta Patil* and Gita Chaurasia

Mahatma Gandhi Vidya Mandir’s College of Pharmacy, Panchvati, Nashik, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4371-75

4371-4375

1553

574

36.

ENHANCEMENT OF DISSOLUTION RATE OF CIPROFLOXACIN BY USING VARIOUS SOLID DISPERSION TECHNIQUES

The aim of this research wok is to formulate and evaluate Ciprofloxacin solid dispersions system by using the different techniques. This will increase the solubility of the drug or Ciprofloxacin and give the immediate release of the drug from the formulations. The main objective is to formulate a drug product as immediate release oral solid dosage form of Ciprofloxacin solid dispersion system whic...

Brahmaiah Bonthagarala*, Leela Madhuri Pola and Sreekanth Nama

Department of Pharmaceutics, Priyadarshini Institute of Pharmaceutical Education & Research (PIPER), 5th Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India

DOI: 25 October, 2013

4376-4383

3046

781

37.

ACUTE AND SUB ACUTE TOXICITY STUDY ON SIDDHA DRUG VELVANGA PARPAM

Benign Prostatic Hyperplasia (BPH) is a common progressive disease among men, with an incidence that is high among elderly.  Velvanga parpam (VP) has been employed as traditional remedy for Benign Prostatic Hyperplasia (BPH) which is a herbo mineral formulation. As a mandate, steps were taken to evaluate safety profile of VP in rats and mice following OECD guidelines. Acute toxicity studies, diff...

K. Samraj*, K. Kanagavalli , P. Sathiya Rajeswaran and P. Parthiban

PG Research Scholar, Maruthuvam Branch, Government Siddha Medical College, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4384-91

4384-4391

2151

718

38.

VARIATION IN β – SITOSTEROL CONTENT FROM CASSIA FISTULA L. FRUIT PULP COLLECTED FROM DIFFERENT GEOGRAPHICAL REGIONS

Cassia fistula L. (Fabaceae) fruits are reported to possess a wide range of therapeutic properties. In the present work, an HPTLC method has been developed and validated for estimation of β-sitosterol content in C. fistula fruit collected from different geographical regions in and outside India and its polyherbal formulation. Chromatographic separation was achieved on HPTLC plates pre-coated with...

S. Shailajan*, M. Yeragi, A. Matani and D. Gurjar

Herbal Research Laboratory, Ramnarain Ruia College, Matunga (E), Mumbai 400019, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4392-96

4392-4396

2817

782

39.

ACETYLATION AND CHARACTERIZATION OF ENSET STARCH AND EVALUATION OF ITS DIRECT COMPRESSION AND DRUG RELEASE SUSTAINING PROPERTIES

Enset (Ensete ventricosum, Musaceae), a plant widely cultivated in south and southwest of Ethiopia, has been shown to be a rich source of starch. In an effort to produce directly compressible matrix-forming excipient, native enset starch was acetylated. Starch acetates (SA) with degrees of substitution (DS) of 0.672 and 2.142 were evaluated. Fourier transform infrared (FTIR) spectra of the modifie...

Efrem Nigussu, Anteneh Belete and Tsige Gebre-Mariam*

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4397-09

4397-4409

1693

860

40.

POSTNATAL DEVELOPMENT OF STOMACH IN SWISS MICE INDUCED BY LEAD ACETATE

Histopathological changes in developing stomach caused by lead acetate exposure at different days of the postnatal development were investigated in Swiss mice. In this study, pregnant Swiss mice were exposed to 533 mg/kg BW of lead acetate from 10th day of gestation to 21st day of lactation. The pups of exposed groups were sacrificed at 1, 7, 14 and 21 day of lactation period, and the effects of l...

Ragini Sharma, Isha Barber*, Khushbu Panwar and Amit Purohit

Environmental and Developmental Toxicology Research Lab., Department of Zoology, University College of Science, Mohanlal Sukhadia University, Udaipur- 313001, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4410-15

4410-4415

1441

597

41.

NOVEL SYNTHESIS OF OXADIAZOLE DERIVATIVES WITH PYRIMIDINE MOIETY

A series of  different  6-Methyl - 4- aryl -5 - (5-aryl -1,3,4-oxadiazole-2-yl ) -1,2,3,4-tetrahydro pyrimidin-2- (1H) - one / thione ( IIIa-g) have been synthesised fromEthyl - 6- methyl- 2- oxo / thioxo – 4-substituted phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate (Ia-g) followed by reaction with hydrazine hydrate in ethanol gave 6 - methyl-2-oxo / thioxo – 4 -substituted phenyl - 1,2...

Shubhangi P. Waghamale and Pravina B. Piste*

P.G. Department of Chemistry, Yashavantrao Chavan Institute of Science, Satara- 415 001, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4416-21

4416-4421

1631

467

42.

COMBINED EFFECTS OF PLANT GROWTH PROMOTING RHIZOBACTERIA AND FUNGI ON MUNG BEAN (VIGNA RADIATA L.)

In the present study, screened PGPR and Fungi were influence the growth of Mung bean (Vigna radiata) plant in the pot. Two rhizobacteria viz. Rhizobium sp., Pseudomonas putida and three fungiAspergillus niger, Rhizopus sp. and Trichoderma viride were isolated and purified. The effect of inoculation of different strains of bacteria and fungus on growth responses of Vigna radiata under pot condition...

Ravi Kumar Gangwar , Gaurav Bhushan , Jaspal Singh *, Sudhir K. Upadhyay and A.P. Singh

Department of Environmental Science, Bareilly College, Bareilly, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4422-26

4422-4426

2646

672

43.

HEPATOPROTECTIVE ACTIVITY OF ETHYL ACETAE EXTRACT OF CRATAEVA MAGNA BUNCH HAM STEM BARK ON RATS

The present study was conducted to evaluate the hepatoprotective activity of ethyl acetate extract of stem bark of Crataeva magna (CM) in CCl4 induced toxicity in Wistar albino rats. Stem bark of CM were collected, and subjected to continuous hot extraction in a Soxhlet apparatus, for 72 h with solvents like chloroform, ethyl acetate and distilled water separately. Liver damage was induced in rats...

G. Babu*, T.A. Divya, N.K. Shalima, T. Divya and C.R. Biju

Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram Dist, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4427-31

4427-4431

1526

715

44.

SPECTROPHOTOMETRIC ESTIMATION OF MONTELUKAST FROM BULK DRUG AND TABLET DOSAGE FORM

Two Simple, accurate, precise and sensitive spectrophotometric methods for estimation of Montelukast sodium (MON) have been developed and validated. The zero order spectroscopic method (Method I) and area under curve method (Method II) have developed. The proposed methods are validated according to ICH Q2B guidelines. The Montelukast sodium gives maximum absorbance at 241nm in chloroform and obser...

S.R. Bhagade

Government College of Pharmacy, Vidhyanagar, Karad. Dist-Satara, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4432-34

4432-4434

1618

616

45.

A NOVEL STABILITY INDICATING HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF GUAIPHENESIN, CHLORPHENERAMINE MALEATE & DEXTROMETHORPHAN HBr

An isocratic HPLC method with UV detection at 225nm is described for simultaneous determination of Guaiphenesin, Chlor-pheneramine Maleate & Dextromethorphan HBr. Chromatographic separation of all three drugs were achieved on Purospher star RP-18e column (Merck) using Mobile phase as 74% Buffer (prepared by dissolving 1.8g dipotassium hydrogen orthophosphate in 1 litre of HPLC grade water, adj...

Tarun Goyal

Department of Quality Control, Overseas Health Care Pvt. Ltd., 335Km Milestone, N.H -1, P.O. Box 25, Phillaur-144410, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4435-41

4435-4441

2321

2104

46.

NOVEL TOPICAL QUICK PENETRATING SOLUTION OF HEPARIN IN MANAGEMENT OF SUPERFICIAL THROMBOPHLEBITIS: RESULTS OF RANDOMIZED ACTIVE CONTROLLED TRIAL

Aim: To compare safety and efficacy of topical quick penetrating solution (QPS) of heparin 1000 IU/ml versus heparin gel 200 IU/g in the management of post infusion superficial thrombophlebitis. Methods:  Total 202 patients of early, medium and advance stage ofsuperficial thrombophlebitis were randomized to receive either treatment. Treatments were applied 3 times daily until healing or for a ...

Avinash Supe , B.M. Subnis , M. Rajeev Rao , Vasantray H. Panchal , R. J. Lakhani , Bhavin Mehtalia , Sanjay Kumar H. Maroo*, Ketan R. Patel , Rakesh U. Ojha and Dixit D. Patel

Sr. General Manager, Medical Services Department, Troikaa Pharmaceuticals Ltd., Commerce House 1, Opp.Rajvansh Apartment, Satya Marg, Bodakdev, Ahmedabad - 380054 Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4442-47

4442-4447

6216

0

47.

ACUTE AND SUBACUTE TOXICITY STUDY ON SPERMATOGENIC SIDDHA DRUG ‘ISAPPUKOL CHOORANAM’ (IC)

Herbal medicines have been broadly used in developed countries hence they are natural and comparatively safe. They contain plant materials as their pharmacologically active components. Infertility is one of the most extremely tragic all over the world. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. The male infertility is mainly due t...

S. Thillaivanan*, K. Kanagavalli , P. Sathiyarajeswaran and P. Parthiban

PG Research Scholar, Maruthuvam Department, GSMC, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4448-56

4448-4456

1716

682

48.

RAS GTPase AS THE DRUG TARGET FOR ANTI-CANCER DESIGNING OF DRUG FROM TEMPLATE

Ras proteins in association with GTP and GDP act as a bio-molecular switch for signaling cell growth, cell survival and signal transduction. The presence of mutated Ras proteins is found to vary in different cancer types and the highest occurrence of about 90% is observed in pancreatic cancer.  The Ras GTPase binding site is mainly involved in signal cell proliferation. Hence, this binding site h...

A.S. Krishnapriya and P.K. Krishnan Namboori*

Computational Chemistry Group, Amrita Molecular Modeling and Synthesis (AMMAS) Research Laboratory, Computational Engineering and Networking, AMRITA Vishwa Vidyapeetham, Amritanagar, Coimbatore-641 112, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4457-61

4457-4461

1536

611

49.

DESIGN AND EVLUATION OF COLLOIDAL CARRIER SYSTEM FOR ORAL DELIVERY OF ENZYME

The purpose of this work is to evaluate the possibility of enzyme therapy through microencapsulation of serratiopeptidase (SP) in biodegradable nanoparticles of chitosan (CS). This drug has short biological half-life and thus frequent administration makes it a suitable candidate for controlled release. In this study, serratiopeptidase loaded chitosan nanoparticles were prepared by ionotropic gelat...

B. Srinath*, K.S. Jaganathan and K.N. Jayaveera

Raghavendra Institute of Pharmaceutical Education and Research, Krishnam Reddy Palli Cross, Chiyyedu Post, Anantapur-515721, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4462-69

4462-4469

1442

561

50.

2D-QSAR ANALYSIS OF PHTHALIMIDE DERIVATIVES AS POTENT HYPOGLYCEMIC AGENTS

A quantitative structure activity relationship study on series of total thirty three pthalimide analogues reported compounds was taken. Pthalimide analogues have several advantages over present ant diabetic drugs. The present drugs target insulin resistance and insulin insufficiency. So, it is believed that agents will be available alternative to other second line treatment options including sulfo...

Sumitra Nain*, Garima Mathur and Anu Sharma

Department of Pharmacy, Banasthali University, Banasthali, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4470-76

4470-4476

1670

753

51.

RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF CAPECITABINE EXTENDED RELEASE TABLET DOSAGE FORM

A Simple, Rapid, Precise, Accurate, Robust and Stability indicating Reverse Phase HPLC method has been developed to estimate Capecitabine in tablet dosage form using mobile phase mixture consisting of Phosphate buffer : Acetonitrile (80:20) v/v at the flow rate of  1.2ml/min. The Hypersil BDS C8 column (250mm x 4.6mm x 5mm) was used as the stationary phase. The mobile phase was run for 15 min at ...

A. Santosh Kumar Sreevatsav* and A.K. Harishbabu

MRR Institute of Pharmacy, Nadergul, Saroornagar, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4477-87

4477-4487

2807

721

52.

ROLE OF VITAMINS ON LEAD INDUCED ALTERATIONS IN DEVELOPING TESTIS OF SWISS MICE

Aim: The aim of the present study was to evaluate lead toxicity on the male reproductive system during developing period of neonates. Methods: Histopathological alterations were observed in testis of neonates on PND 1 and PND 21. Lead acetate was administered via oral gavaging at 320 mg/kg BW to pregnant Swiss mice from 10th day of gestation upto 21st day of lactation. OralExposure of 160 mg/kg...

Ragini Sharma and Umesh Garu

Environmental and Developmental Toxicology Research Laboratory, Department of Zoology, University College of Science, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4488-93

4488-4493

1541

475