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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 6 (2015) - Issue 9, September

Review Articles

 
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1.

RESVERATROL: RECOMMENDING ITS WIDE INCREASE – A PREMATURE DECISION OR NOT? A REVIEW

Resveratrol, an antioxidant found in red wine and certain foods, has been touted as a natural way to slow aging and fight cancer, obesity, heart disease, and diabetes. It also could be accounted as an agent, which has effects to reduced risk of inflammation and blood clotting. In addition there are some studies showing that resveratrol may actually reduce the positive effect of exercise on the hea...

M. Georgieva *, I. Valkova , B. Zlatkov , L. Andonova and A. Zlatkov

Department of Pharmaceutical chemistry , Faculty of Pharmacy, Medical University,Sofia, Bulgaria

DOI: 10.13040/IJPSR.0975-8232.6(9).3641-53

3641-53

2734

1271

2.

EFFECT OF SEASONAL VARIATION ON SECONDARY METABOLITES OF MEDICINAL PLANTS

Seasonal fluctuations are periodical series, and have impact on availability of active principles in medicinal plants hence, therapeutic efficacy also get influenced. The survey of several scientific studies published in scientific journals of international repute indicates this fact. The studies reported that essential oil component shows a rhythmic increase in oil production throughout the growi...

Uma Soni, Seema Brar and Vinod Kumar Gauttam*

Department of Pharmacognosy, ISF College of Pharmacy, Moga, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3654-62

3654-62

6755

1868

3.

ETHOSOMES – A PROMISING WAY FOR TRANSDERMAL DRUG DELIVERY

One of the major advances in vesicle research was the finding that some modified vesicles possessed properties that allowed them to successfully deliver drugs in deeper layers of skin. Transdermal delivery is important because it is a noninvasive procedure for drug delivery. Further, problem of drug degradation by digestive enzymes after oral administration and discomfort associated with parentera...

Sunisha Kulkarni*, Kaushal Prasad Mishra, Shyam Bihari Sharma and Suman Jain

S. O. S. In Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3663-70

3663-70

3835

1099

4.

A REVIEW ON PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE OF ELYTRARIA ACAULIS LINDAU

Elytraria acaulis Lindau, Acanthaceae (Family), also known as the Asian scalystem places itself an important position in the history of Indian system of medicine. It is found throughout Nigeria, Angola,Ghana, Uganda, Kenya, Botswana, Malawi, Mozambique, Zambia, Zimbabwe, Tanzania, South Africa, Somalia and India. Indian ayurveda explored in treating several ailments by using natural products deriv...

P. Sathish Babu, K. Anand Babu*, K. Chitra and D. Chamundeeshwari

Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3671-75

3671-75

3005

1225

5.

PULSATILE DRUG DELIVERY SYSTEM – A REVIEW

Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Thus drug can be delivered at right time, in right  amount and at right site of action by use of such approach. The potential benefits of...

Vidhi R. Patel * and Vipulbhai P. Patel

Department of Pharmaceutical Technology, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3676-88

3676-88

4543

1255

6.

FUTURE PROSPECTS OF COUGH TREATMENT; HERBAL MEDICINES v/s MODERN DRUGS

Drugs currently used to treat cough are among the most widely used over-the-counter drugs in the world, despite a recent analysis suggesting that there is a little evidence to such drugs produce any meaningful efficacy. The primary action of currently available cough suppressants (opiates, dextromethorphan etc.) is on the central cough pathway. The significant side effects of these agents such as ...

Y. Jahan, T. Mahmood*, P. Bagga, A. Kumar, K. Singh and Md. Mujahid

Faculty of Pharmacy, Integral University, Kursi Road, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3689-97

3689-97

4617

2386

7.

A REVIEW ON SOLID LIPID NANOPARTICLE (SLN): AN ADVANCED TREATMENT MODALITY

SLN is a challenging field of nanotechnology notified in the recent years. It has been proved that SLN is more beneficial colloidal drug delivery system because of its more controlled and targeted properties. Recent advances in nanotechnology has indicated unimaginable guarantee to adjust disease therapeutics by creating new treatment modalities which may permit better focused delivery of anticanc...

Pritee S. Mahajan*, Kishor B Mahajan and A. B. Darekar

R.G. Sapkal College of Pharmacy, Nashik, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3698-12

3698-12

2936

986

8.

E7010: INVESTIGATIONAL ANTICANCER AGENTS TARGETING THE MICROTUBULES

E7010 (N-[2-[(4-hydroxyphenyl)amino] – 3 pyridinyl] – 4 -methoxybenzenesulfonamide), an orally active sulfonamide antitumor agent that is currently in a Phase I clinical trial, showed rather consistent growth-inhibitory activities against a panel of 26 human tumor cell lines (IC50 = 0.06–0.8 µg/ml), in contrast to vincristine (VCR; IC50 = 0.0002–0.04 µg/ml), 5-fluorouracil (IC50 = 0.2...

Kesari Lakshmi Manasa

M.S-Pharm (Medicinal Chemistry), NIPER - Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3713-25

3713-25

2179

787

Research Articles

 
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9.

IN-VITRO ANTI-CHOLINESTERASE ACTIVITIES BY PIPERINE, AN ALKALOID FROM THE SPICE FAMILY PIPERACEAE

The alkaloid piperine from the spice family Piperaceae has been reported to possess poly-pharmacological activities including anti-depressant and cognitive enhancing effects. It has been suggested that its neurocognitive benefits may be via its activity on the cholinergic system, particularly on the enzyme acetylcholinesterase (AChE), a pharmacological target for neurodegenerative disease such as ...

E. J. Okello*, A. Coleman and C. J. Seal

Human Nutrition Research Centre, School of Agriculture, Food and Rural Development, Faculty of Science and Engineering, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom

DOI: 10.13040/IJPSR.0975-8232.6(9).3726-32

3726-32

3550

992

10.

VASORELAXATION EFFECT PROMOTED BY THE CALCIUM CHANNEL BLOCKER VERAPAMIL COORDINATED TO RUTHENIUM (II): CHEMICAL AND BIOLOGICAL PROPERTIES

This paper presents the synthesis and physical-chemical characterization of a new terpyridine (tpy) ruthenium complex coordinated to the L-type calcium blocker channels verapamil (vera) obtained from commercial pill. Elemental analysis (%C N H), infrared (IR) and ultraviolet-visible (UV-vis.) spectroscopy, mass spectrometry (MS), and 13CNMR (nuclear magnetic resonance), and HPLC (high performance ...

O. A. Nascimento, E. F. Boffo , B. R. Silva, J. C. Biazzotto, L. M. Bendhack, R. S. da Silva and R. G. de Lima

Departamento de Química , Universidade Federal da Bahia, Avenida Barão de Geremoabo number 147 , Ondina, Salvador, BA, Brazil

DOI: 10.13040/IJPSR.0975-8232.6(9).3733-43

3733-43

2033

753

11.

MEMBRANE SENSORS FOR THE SELECTIVE DETERMINATION OF TOLTERODINE TARTRATE IN PRESENCE OF ITS DEGRADATION PRODUCT

The construction and electrochemical response characteristics of polyvinyl chloride (PVC) membrane sensors for determination of Tolterodine tartrate (TT) in presence of its oxidative degradation product are described. The sensors are based on the ion association complexes of TT cation with sodium tetraphenyl borate (TT-TPB) [sensor 1] or phosphomolybidic acid (TT-PMA) [sensor 2] counter anions as ...

Khalid A. Attia, Nasr M. El-Abasawy, Ahmed M. Abdelraoof * and Mona H. Abdelrahman

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(9).3744-51

3744-51

2191

789

12.

SALIVA AS A NONINVASIVE BIOLOGICAL SAMPLE TO COMPARE BIOAVAILABILITY OF PHENYTOIN FORMULATIONS BY LC-MS/MS

The use of noninvasive biological samples such as saliva, it is of great interest for therapeutic drug monitoring (TDM), including the anticonvulsants Phenytoin (PHT). A simple analytical methodology by liquid chromatography-tandem mass spectrometry was developed and validated to carry out a relative comparative bioavailability (RBA) study of two PHT formulations in human plasma and saliva and the...

M. N. Baldo, G. A. Hunzicker , J. C. Altamirano , M. C. Murguía and G. J. Hein *

Instituto de Ciencias Veterinarias del Litoral, (ICiVet Litoral) - Universidad Nacional del Litoral (UNL) - CONICET, Esperanza, Santa Fe, Argentina

DOI: 10.13040/IJPSR.0975-8232.6(9).3752-60

3752-60

2330

870

13.

PREPARATION AND EVALUATION OF MUCOADHESIVE GELLAN GUM IN-SITU GELS FOR THE OCULAR DELIVERY OF CARBONIC ANHYDRASE INHIBITOR NANOVESICLES

A novel approach was tested utilizing mucoadhesive in-situ gelling (ISG) Gellan Gum /HPMC solutions containing dispersions of methazolamide (MZA) loaded Spanlastic Vesicular systems (SVs). The tested systems were designed to combine high corneal permeability of SVs as well as ease of application and prolonged eye retention of ISGs. SVs consisted of Span 60 mixed with different ratios of edge activ...

Rania Elazreg, Mahmoud Soliman *, Samar Mansour and Abdelhameed El Shamy

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.6(9).3761-74

3761-74

2806

1111

14.

EFFECT OF PROCESSING ON AMINO ACIDS CONTENTS OF FOUR SPECIES OF THE FAMILY CUCURBITACEAE

This study was carried out to evaluate the effect of boiling on amino acids contents of the fruits of four species of the family Cucurbitaceae which were Cucurbita maxima D, Cucurbita pepo L, Cucurbita moschata and Lagenaria siceraria variety supreme court. In this study, fresh fruit of the four species were subjected to conventional processing technique which is boiling as well as drying. The dry...

Ihsan Mohamed Elhadi , Mona A M Abd El Mageed * and Yahia Mohamed El Imam

Department of Pharmacognosy , Faculty of Pharmacy, Omdurman Islamic University, Sudan

DOI: 10.13040/IJPSR.0975-8232.6(9).3775-80

3775-80

1738

629

15.

VIABILITY OF ADIPOSE-DERIVED STEM CELLS (ASCs) ON POROUS CHITOSAN SCAFFOLD

Background: Stem cells have great potential in regenerative medicine due to their multipotentiality. Treatments involving cell sheets for tissue reconstruction require a large number of cells to repair the tissue damage, and the cells are fragile. Combined with a porous chitosan scaffold (PCS), adipose-derived stem cells (ASCs), which are ubiquitous, can be delivered to a target tissue in vivo. Th...

M. Mohamed , S. Gomathysankar , AZ Mat Saad , Kartini Noorsal and AS Halim *

School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

DOI: 10.13040/IJPSR.0975-8232.6(9).3781-87

3781-87

1526

570

16.

QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING ANALYSIS OF CHOLESTEROL INHIBITORS AGAINST NIEMANN-PICK C2 TARGET GENE (NPC2)

In an effort to develop new targets with enhanced antihyperlipidemic activity, seven new inhibitors such as beta-sitosterol, cholesterol, cholesterol sulfate, desmosterol, lathosterol, stigmasterol and cholesterol acetate was targeted using in silico docking experiments with the modeled structure of the Niemann-Pick C2 target gene (NPC2). Quantitative structure–activity relationship models (QSAR...

Shilu Mathew and Ishtiaq Qadri *

Medical Biotechnology and Translational Medicine Research, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah, Saudi Arabia

DOI: 10.13040/IJPSR.0975-8232.6(9).3788-95

3788-95

1752

699

17.

NEUROPHARMACOLOGICAL EVALUATION OF ETHANOLIC LEAF EXTRACT OF ALTERNANTHERA BRASILIANA (L.) KUNTZE (AMARANTHACEAE) IN MICE

Alternanthera brasiliana is a medicinal plant used in the folkloric treatment of malaria, pains, infections and diabetes in South-western states of Nigeria. Recent reports indicate some central activities for the plant. This study evaluated ethanolic leaf extract of the plant for novelty-induced behaviour, anxiety, sedation and convulsion in mice. Dried powdered leaves of the plant were extracted ...

I. A. Oyemitan , O. A. Bello and L. A. Akinpelu

Department of Chemistry, Walter Sisulu University, Nelson Mandela Drive Campus, Mthatha, South Africa

DOI: 10.13040/IJPSR.0975-8232.6(9).3796-08

3796-06

1876

853

18.

EFAVIRENZ DISSOLUTION ENHANCEMENT II: AQUEOUS CO-SPRAY-DRYING

Efavirenz is a crystalline lipophilic solid with a low aqueous solubility and intrinsic dissolution rate. It is classified in class II of the Biopharmaceutics Classification System, which means it is poorly water-soluble and highly permeable. Spray drying is a widely used manufacturing process wich uses the aerosol phase to dry particles. By modifying the spray drying operation parameters, it is p...

M. A. da Costa , V. O. F. Lione , C. R. Rodrigues , L. M. Cabral and H. V. A. Rocha *

Laboratório de Sistemas Farmacêuticos Avançados - LaSiFA- Farmanguinhos/ FIOCRUZ – Rio de Janeiro – RJ – Brazil

DOI: 10.13040/IJPSR.0975-8232.6(9).3807-20

3807-20

2053

826

19.

EVALUATION OF IN-VITRO ANTIOXIDANT AND BRINE SHRIMP LETHALITY ACTIVITIES OF FRUIT EXTRACT OF AVERRHOA CARAMBOLA L.

Research with plants and plant derivatives are increasing day by day for the discovery of therapeutic and nutraceutical agents from them and due to the versatile applications of those beneficial agents. The present study was thus designed to investigate the antioxidant and cytotoxic properties of methanolic Averrhoa carambola L. fruit extract along with the identification of the phytochemicals pre...

Md. R. Hasan *, T. Islam , A. Roy , Md. S. Islam, Md. A. Islam and Md. Rafiquzzaman

Department of Pharmacy , Jahangirnagar University, Savar, Dhaka , Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(9).3821-28

3821-28

1851

859

20.

COMPARATIVE EVALUATION OF DIFFERENT BRANDS OF ENTERIC-COATED DICLOFENAC SODIUM TABLETS

Diclofenac sodium is a non-steroidal anti-inflammatory drug with wide use in the treatment of rheumatic diseases. Enteric-coated tablet form of this drug has been developed to prevent the gastric irritation problem encountered with its use and to improve its efficacy. The enteric film coat resists solution in gastric fluid and disintegrates and releases the medication in the intestines. Many brand...

A. Almarzouki, K. Omar, M. Elmajiri and M. Alsaadi *

Department of Industrial Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya

DOI: 10.13040/IJPSR.0975-8232.6(9).3829-35

3829-35

4343

970

21.

QUANTIFICATION OF A CRUDE EXTRACT FROM HEDERA COLCHICA

Crude extract from the leaves of Hedera colchica (C. Koch) C. Koch proved to have an antiulcer activity in pharmacological experiences. Hederacolchisid F (HCF) is being the chemical marker of this plant, a simple and reliable HPLC method is developed for the quan­ti­ta­ti­ve evaluation of the extract using this compound. The chromatographic separation was achieved using an Eclipse XDB-Phenyl c...

Malkhaz Getia *, Vakhtang Mshvildadze, Genri Dekanosidze and André Pichette

Tbilisi State Medical University’s Iovel Kutateladze Institute of Pharmacochemistry , Laboratory of Terpenic Compounds, 36 P. Sarajishvili, Tbilisi, Georgia

DOI: 10.13040/IJPSR.0975-8232.6(9).3836-40

3836-40

1637

873

22.

INVITRO ANTIOXIDANT STUDY AND SEARCH FOR A NOVEL BIOACTIVE COMPOUND FROM LEAVE FRACTIONS OF CANTHIUM COROMANDELICUM (BURM.F.) ALSTON

Background: Plants are enriched with various types of phytoconstituents present in the form of secondary metabolites that ensure its medicinal value. Keeping this in view, the present investigation was carried out focusing on its antioxidant property that may mainstay of exploring other therapeutic potency. Hence, phytochemical investigation followed with antioxidant property was evaluated in the ...

Sanjeeb Kumar Patro and Dinakar Sasmal *

Department of Pharmaceutical Sciences and Technology, Birla Institute Technology, Mesra, Ranchi, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3841-52

3841-52

2039

970

23.

EFFECT OF ETANERCEPT AGAINST MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN MALE MICE

Objective: This study was undertaken to investigate the potential role of etanercept in amelioration of myocardial I/R injury induced by ligation of coronary artery in a mice model. Materials & methods: Adult male Swiss Albino mice were randomized into 4 equal groups. Group (1) sham group: mice underwent the same anesthetic and surgical procedure as the control group except ligation of LAD cor...

Saif M. Hassan

Department of Pharmacology and Therapeutics, College of Medicine, Kufa University, Kufa, Iraq

DOI: 10.13040/IJPSR.0975-8232.6(9).3853-60

3853-60

1671

634

24.

EFFECT OF CICHORIUM INTYBUS LEAVES ON N- NITROSODIETHYLAMINE INDUCED HEPATOTOXICITY IN WISTAR RATS

Cichorium intybus (Asteraceae) is used as traditional medicine in India for various liver related disorders. The present study evaluates the hepatoprotective potential of leaf extract on N- nitrosodiethylamine induced hepatotoxicity, which is commonly present in foods, beverages, tobacco smoke, herbicides, pesticides, drinking water, and industrial pollution. The leaves were sorted as per their si...

Neha Mathur , Vidhu Aeri * and Deepshikha Pande Katare *

Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3861-71

3861-71

2052

673

25.

SYNTHESIS AND ANALYTICAL METHOD DEVELOPMENT OF A NEW PRODRUG OF ACECLOFENAC

In the present work, a prodrug (2) of aceclofenac was synthesized using N-hydroxymethylisatin (1) as promoiety. Its structure was established on the basis of modern analytical techniques. An analytical, rapid, cost-effective and accurate method using UV-spectroscopy has been developed for the synthesized prodrug. The results and calibration curves obtained with different solvents for the prodrug r...

Niti Bhardwaj, P. Ahuja , Farah Iram and Asif Husain *

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India

DOI: DOI: 10.13040/IJPSR.0975-8232.6(9).3872-76

3872-76

1674

722

26.

NOVEL BULK FORMING LAXATIVE FROM WATERMELON RIND

A laxative formulations are widely used for treatment of constipation. They are classified based on their mechanism of action such as bulk forming, stool softener, osmotic, stimulant and mechanical. Bulk forming laxative is most commonly used laxative which works   by absorbing water and swelling in small and large intestine to form soft and bulky stool. Presently available bulk forming laxative...

Ashish G. Waghmare, Sonal U. Patil and Shalini S. Arya*

Food Engineering and Technology Department, Institute of Chemical Technology, Matunga, Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3877-84

3877-84

2370

1955

27.

FORMULATION AND CHARACTERIZATION OF BORIC ACID TOPICAL FORMULATIONS

The present study depicts formulation and characterization of boric acid gel formulations. The formulated gels intervenes the advantages of gels along with higher and effective antimicrobial activity when compared to the formulations available in the market. The preparations were evaluated for different parameters as basic physico-chemical properties like physical appearance, texture, pH measureme...

Sarbjeet Singh Gujral, Pratibha Nand* and Deepti Makhija

Maharaja Surajmal Institute of Pharmacy, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3885-91

3885-91

3589

819

28.

AMELIORATION OF DIABETES BY SWIETENIA MAHAGONI IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Sweitenia mahagoni is a natural medicine used to treat various human ailments including diabetes. The present study is a comprehensive approach which targets more than one locus in the diabetic model to enumerate the anti-diabetic potential of Swietenia mahagoni as claimed by folklore. Oral administration of the aqueous extract of the leaf decreased the fasting blood glucose level (155.2±6.7) fro...

Naveen Y. P. and Asna Urooj *

DOS in Food Science and Nutrition, University of Mysore, Manasagangothri, Mysore, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3892-00

3892-00

1865

675

29.

FORMULATION DESIGN AND IN-VITRO EVALUATION OF ZOLMITRIPTAN GASTRORETENSIVE FLOATING MATRIX TABLETS FOR MANAGEMENT OF MIGRAINE

Objective: The objective of the present investigation was to formulate and evaluate hydrodynamically balanced floating matrix controlled drug delivery system of Zolmitriptan by increasing its residence time and improves the bioavailability. Methods: Twelve different formulations of floating tablets were prepared using direct compression technique with hydrophilic polymers such as HPMC K4M, K15M, K...

Rana Zafar and Niranjan Panda *

PG Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telengana, India.

DOI: 10.13040/IJPSR.0975-8232.6(9).3901-12

3901-12

2468

867

30.

IMMOBILIZED BACTERIOPHAGE USED FOR SPECIFIC DETECTION OF E.COLI USING ELECTROCHEMICAL IMPEDANCE SENSING

In the present study, bacteriophage based electrochemical analysis is applied to detect pathogenic E.coli bacteria. Phages are parasites that only infect one specific bacteria, can be useful to identify bacterial contaminants in food, water, etc. Phage has been isolated from various water sources such as waste, stagnant and sewage water by overlay method against host bacteria. Titer of phages was ...

Vipin Singh, Vidushi Rawal, Saachi Lakhanpal, Pranay Jain *, Swati Dahiya and C.C. Tripathi

Department of Biotechnology Engineering ,University Institute of Engineering and Technology, Kurukshetra University, Kurukshetra, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3913-19

3913-19

2524

660

31.

ANTIFUNGAL ACTIVITY OF TRYPSIN INHIBITORS FROM THE SEEDS OF ABELMOSCHUS MOSCHATUS

The aim of the present study was to investigate the antifungal potential of trypsin inhibitors (AMTI-I and AMTI-II) isolated from the seeds of Abelmoschus moschatus on selected pathogenic fungal strains. The purified inhibitors have been found to be homogenous by the criteria of native PAGE and gel filtration with apparent molecular weights of 22.4kDa and 21.2 kDa as judged by SDS-PAGE. While both...

Muni Kumar Dokka, Lavanya Seva and Siva Prasad Davuluri *

Department of Biochemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3920-27

3920-27

1918

635

32.

PRELIMINARY SCREENING OF ETHNOMEDICINAL PLANTS FOR ANTIBACTERIAL ACTIVITY

Based on the ethno botanical survey and the related literature, 285 solvent extracts from 57 ethno medicinal plants belonging to 55 genera and 34 families were subjected to preliminary screening for antibacterial activity against Escherichia coli and Bacillus subtilis using agar well diffusion method at concentrations of 5 & 2.5 mg/ml. Among 285 plant extracts, some exhibited very effective ac...

Rekha Sharanappa and G. M. Vidyasagar *

Medicinal Plants and Microbiology Research Laboratory, Department of Post-Graduate Studies and Research in Botany, Gulbarga University, Kalaburagi, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3928-35

3928-35

1861

635

33.

PHYTOCHEMICAL ANALYSIS OF ETHANOL EXTRACT OF AMPELOCISSUS LATIFOLIA (ROXB.) PLANCH TUBEROUS ROOT USING UV-VIS, FTIR AND GC-MS

The present investigation was carried to determine UV-VIS, FTIR and GC-MS analysis of Ampelocissus latifolia tuberous root. The ethanol extract was examined under visible and UV light for the proximate analysis. The UV‐VIS profile of Ampelocissus latifolia tuberous root ethanol extract showed the peaks at 409 nm, 424 nm and 479 nm with the absorption of 1.682, 1.704 and 1.479 respectively. The F...

K. B. Theng * and A. N. Korpenwar

Department of Botany, Shri Shivaji Science and Arts College Chikhli, Dist- Buldhana, M.S. India

DOI: 10.13040/IJPSR.0975-8232.6(9).3936-42

3936-42

2153

1146

34.

ANTI CONVULSANT POTENTIAL OF LEAVES OF PSIDIUM GUAJAVA LINN. IN MES AND PTZ INDUCED CONVULSION IN EXPERIMENTAL ANIMALS

Objectives: To study the anti-convulsant potential of leaves of Psidium guajava Linn. in MES and PTZ induced convulsion in experimental animals. Materials and methods: The anticonvulsant potential of the ethanolic extracts of Psidium guajava Linn. (EEPG) were tested in the mice model of Maximal electroshock (MES) and Pentylenetetrazole (PTZ). In the MES model, seizures were induced by delivering e...

J. Lahon *, S. Phukan , M. Lahkar and U. Sharma

Department of Pharmacology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Mawdiangdiang, Shillong, Meghalaya, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3946-53

3946-53

2107

672

35.

GC MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF SEED OIL OF BROUSSONETIA PAPYRIFERA (L.) VENT

The current study focuses on evaluating chemical composition and antimicrobial activity of seed oil of Broussonetia papyrifera; a widely used Chinese medicinal plant. The chemical constituents of the oil were evaluated by GC‑MS analysis. Antimicrobial activity and minimum inhibitory concentrations were determined by disk diffusion and agar dilution methods. The seed oil contains 46 different p...

N. Naveen Kumar , H. Ramakrishnaiah *, V. Krishna and A. P. Deepalakshmi

Department of PG Studies and Research in Biotechnology, Government Science College, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3954-60

3954-60

1672

1125

36.

COMPARATIVE ANALYSIS OF MOLECULAR INTERACTIONS BETWEEN DRUGS OF AQUEOUS PROPYLENE GLYCOL WITH CERTAIN ALCOHOLS AT 308.15K: AN INSIGHT FROM DENSITY AND VISCOSITY STUDIES

Density, ρ and viscosity, η of drug of aqueous solution of propylene glycol (PG) (3 m and 7 m) with tert-butanol/2-propanol have been measured over the entire composition range of alkanols at 308.15 K. From this experimental data, excess molar volume, , deviation in viscosity, Δη, and excess Gibbs free energy of activation of viscous flow, ΔG*E have been determined. Positive values of Δη, ...

Sk. Md Nayeem and D. Krishna Rao *

Department of Physics, Acharya Nagarjuna University, Nagarjuna Nagar, A.P., India

DOI: 10.13040/IJPSR.0975-8232.6(9).3961-74

3961-74

1724

685

37.

EFFECT OF ETHANOL EXTRACT OF TERMINALIA CHEBULA ON THE MOTILITY AND ACETYLCHOLINESTERASE OF COTYLOPHORON COTYLOPHORUM

Cotylophoron cotylophorum, the parasite of ruminants cause a disease called paramphistomosis. Paramphistomosis in domesticated ruminants cause considerable economic loss to the livestock industry in India. In the present study, the anthelmintic activity of Terminalia chebula was assessed based on its effects on the motility and acetylcholinesterase (AChE) of the digenetic trematode C. cotylophorum...

R. Lokesh and L. Veerakumari*

PG and Research department of Zoology, Pachaiyappa’s College, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3975-80

3975-80

1898

673

38.

CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITY OF LEAF ESSENTIAL OIL OF EUGENIA COTINIFOLIA SSP. CODYENSIS (MUNRO EX WIGHT) ASHTON

The study was carried out to investigate the essential oil composition and antibacterial effects of Eugenia cotinifolia ssp. codyensis leaves. The fresh leaf essential oil was extracted hydrodistillation process using Clevanger apparatus. The compounds of the essential oil were analyzed using Gas Chromatography Mass Spectrometry (GC-MS) technique identified a total of 84 numbers of chemical consti...

R. Sarvesan , P. Eganathan *, J. Saranya and P. Sujanapal

Plant Tissue Culture and Bioprospecting Laboratory, M. S. Swaminathan Research Foundation, Taramani, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3981-85

3981-85

1629

851

39.

EVALUATION OF ANTIOXIDANT POTENTIAL OF DIFFERENT EXTRACTS OF MANGO GINGER (CURCUMA AMADA ROXB.) RHIZOME

The Zingiberaceae has the great importance in the plant kingdom because the members of this family give up spices, perfumes, dyes and valuable medicines. Alongside, a number of species of this family are cultivated for flowering. Mango ginger is one of the important species of this family having medicinal and biological properties such as antiageing, antibacterial, antioxidant, anti-inflammatory, ...

Ravindra Kumar Gupta , Himanshu Gaur , Jayant Kumar Pati and Archana Pandey *

Department of Chemistry, CMP Degree College (Constituent College of University of Allahabad), Allahabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3986-89

3986-89

2865

768

40.

FORMULATION AND CHARACTERIZATION OF SOLID MICROEMULSION OF DARUNAVIR FOR ENHANCED SOLUBILITY AND DISSOLUTION

The solid microemulsion of Darunavir, a promising antiretroviral drug, is attempted in the present work for enhancing the solubility and dissolution rate. For this purpose, solubility of Darunavir was determined in various oils, surfactant and cosurfactants. Pseudo-ternary phase diagrams were constructed to identify the microemulsion existing zone. The optimized formulation consisted of 65% of Cap...

G. R. Dixit * and V. B. Mathur

Sharad Pawar College of Pharmacy, Wanadongari, Hingna Road, Nagpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(9).3990-99

3990-99

2235

908

41.

SIMULTANEOUS SPECTROSCOPIC ESTIMATION AND VALIDATION OF GEMCITABINE AND TAMOXIFEN IN SYNTHETIC MIXTURE BY FIRST ORDER DERIVATIVE METHOD

A novel, simple, rapid and sensitive UV spectrophotometric method has been developed for simultaneous estimation of Gemcitabine and Tamoxifen. Gemcitabine and Tamoxifen show maximum absorbance at 269 nm and 238 nm respectively. The method employs first order derivative method. Here in this method, TAM show zero absorbance i.e Zero Crossing Point (ZCP) at 285 nm and at this wavelength GEM show meas...

M. L. Thakkar, D. B. Shah * and D. G. Maheshwari

Department of Quality Assurance and Pharm Regulatory Affairs, L. J. Institute of Pharmacy, Ahmedabad Gujrat, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4000-03

4000-03

1749

670

42.

DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF ABACAVIR AND ZIDOVUDINE TABLET IN COMBINATION

The present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of Abacavir and Zidovudine tablet.  Combination of anti retiro-viral creates multiple obstacles to HIV replication to keep the number of off springs low,  reduce the possibility of superior mutations, decrease viral load and potentiate synergistic activity with one another, combining two ...

Srinivas Martha* and Satya Devi B.

Department of Pharmaceutics, Joginpally B.R. Pharmacy College, Yenkapally (V), Moinabad (M), Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4004-15

4004-15

1736

756

43.

PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF LEAVES AND STEM BARK EXTRACTS OF GARCINIA IMBERTI – AN ENDANGERED PLANT

Garcinia imberti Bourd. a critically endangered tree belongs to the family Clusiaceae found only in India. The phytochemicals and antioxidant studies were carried out for the methanolic extracts of Garcinia imberti leaves and stem bark using DPPH and ABTS radical scavenging assay. Preliminary phytochemical screening of methanolic extracts of Garcinia imberti revealed the presence of various bioact...

K. Rajkumar , R. Shubharani * and V. Sivaram

Laboratory of Biodiversit, Department of Botany, Bangalore University, Jnana Bharathi, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4016-21

4016-21

2275

898

44.

COMPARATIVE STUDY ON EFFECT OF DIFFERENT CAPPING AGENTS ON THE ANTIMICROBIAL ACTIVITY OF ZNO NANOPARTICLES

The present study focuses on the synthesis of ZnO nanoparticles by chemical method in alcohol base using three different capping agents-Thioglycerol, oleic acid and Triethanol amine (TEA). The effect of concentrations was analyzed for their effectiveness in particle growth   and antibacterial activity. The antibacterial activity of ZnO nanoparticles using these capping agents at different concen...

Shabana Nazneen, Roselin Polugari*, Shailaja Raj and Prerana Singh

Department of Microbiology, St. Francis College for Women, Begumpet, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4022-25

4022-25

2365

791

45.

EMBLICA OFFICINALIS ENHANCES CARDIAC TISSUE REGENERATION IN TADPOLES OF THE FROG RANA CYANOPHLYCTIS (SCHNEIDER)

Emblica officinalis and its derivative (Ascorbic acid) have profound effect on development and regeneration and are widely used in the Indian System of medicine for the treatment of different type of disease. Here, we discussed the comprehensive account of the effect of aqueous extract of the fruit of E.officinalis with special reference to cardiac tissue regeneration in frog tadpoles. E.officinal...

Govind Kumar Gupta* and O.P Jangir

Department of Biotechnology, IASE Deemed University, Sardarshahr, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4026-35

4026-35

1674

573

46.

NON-ENZYMATIC ASSAY BASED IN-VITRO ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL SCREENING OF FREEZE DRIED WHEAT (TRITICUM AESTIVUM L.) SEEDLINGS JUICE POWDER: NATURE’S FINEST MEDICINE-PART-II

Free radical scavenging potential and phytochemical analysis of the two different extracts of lyophilized wheat seedling juice powder (WSJP) Triticum aestivum L.(Gramineae),“Nature’s Finest Medicine” was evaluated in vitro by using diphenyl-picryl-hydrazyl (DPPH) assay and preliminary phytochemical analysis. In this method the antioxidants present in WSJP extracts reacted with DPPH, which is...

H. S. Dhaliwal, N. Sharma, A. Bano, S. Kumar and V. Sharma*

Akal College of Agriculture, Eternal University, Baru Sahib (H.P.) India

DOI: 10.13040/IJPSR.0975-8232.6(9).4036-46

4036-46

1751

1001

47.

POTENTIAL OF CYANOBACTERIA COLLECTED FROM CENTRAL INDIA AGAINST HUMAN PATHOGENIC BACTERIA IN VITRO

The present study showcases a screening program for the hunt of potent antibacterial compounds from cyanobacteria. A total of 108 cyanobacterial samples, from different habitats of the Jabalpur town of Central India, were collected which finally yielded 20 unialgal cultures belonging to ten genera. Ethanolic extracts from seventeen out of twenty cyanobacterial dried masses showed potent antibacter...

Sulekha Yadav , Monica Agrawal, Neelima Raipuria and Manish Kumar Agrawal *

Excellent Bio Research Solutions Pvt. Ltd. , Jabalpur, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4047-52

4047-52

2072

619

48.

TO INVESTIGATE THE EFFECT OF GINGER (ZINGIBER OFFICINALE ROSCOE) ON PENDULAR INTESTINE MOTILITY OF RAT

To investigate the effects of ginger-juice (Zingiber Officinale Roscoe) on rat’s intestinependular motility. Methods: Albino rats were sacrificed to isolate intestine. Concentration of ginger is expressed in term of mg/ml of ginger rhizome. It is based on preparation of ginger-juice as detailed in material and methods section. 150 ml of filtrate used in the isolated experiment represented 500 gm...

S. S. Prasad *, A. Desai , C. Shah, K. Patel, C. Dumatar, S. K. Vajpeyee and V. H. Bhavsar

Department of Pharmacology , GMERS Medical College, Gandhinagar, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4053-57

4053-57

1532

637

49.

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 2-SUBSTITUTED BENZOTHIAZOLE DITHIOMIDOCARBONATE DERIVATIVES

A series of novel 2- substituted benzothiazole dithiomidocarbonate derivatives were synthesized by the reaction of 2-amino benzothiazole with various halides. The test compounds were screened for their antimicrobial activity (antibacterial and antifungal) by disc diffusion method and the results of the microbial activity indicates that the test compounds exhibited varying degree of antimicrobial a...

Tasleem

Department of Pharmaceutical Chemistry, School of Pharmacy, Deccan Group of Institutions, Aghapura, Nampally, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4058-68

4058-68

1473

621

50.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF PHENYLEPHERINE HYDROCHLORIDE AND CETIRIZINE HYDROCHLORIDE IN TABLET DOSAGE FORM

A simple, economical, specific, accurate, precise and validated Reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for simultaneous estimation of Phenylepherine hydrochloride (PPEH) and Cetirizine hydrochloride (CETH) in combine dosage form. The chromatographic separation was achieved on Princeton SPHER C18 column (250 mm x 4.6 mm id, 5 μ particle size) at am...

S. S. Deo , F. Inam , T. B. Deshmukh * and T. L. Lambat

Department of Chemistry, Govt. Institute of Science, Nagpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4069-74

4069-74

3244

665

51.

FORMULATION DEVELOPMENT AND EVALUATION OF FENOFIBRATE AND ROSUVASTATIN IN COMBINATION TABLETS AND RELEASE RATE IMPROVEMENT

The work was aimed to develop an immediate release tablet formulation of Fenofibrate and Rosuvastatin in combination for better treatment as well as management of hypercholesterolemia and prevention of cardiovascular diseases. The target was also set to improve the dissolution profile of poorly soluble Fenofibrate. For manufacturing these immediate release combined formulation tablets, Hot-Melt Te...

Priyanka Sarkar*, Shaila Eamen, Md. Biplob Hossen and Md. Golam Mucktady

Department of Pharmacy, Primeasia University, Banani, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(9).4075-79

4075-79

2596

860

52.

DETECTION OF SILDENAFIL CITRATE FROM APHRODISIAC HERBAL FORMULATIONS

Sildenafil, the active ingredient in Viagra (Pfizer), is a prescription medicine used for erectile dysfunction. Sildenafil were isolated and purified during the analysis of some herbal products marketed for treatment of erectile dysfunction. There is no standardization technique for herbal formulations hence the addition of adulterants in herbal is very difficult to get hold of. Most of the adulte...

Astha Pandey* and Prajal Parikh

Institute of Forensic Science, Gujarat Forensic Sciences University, Gandhinagar, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4080-85

4080-85

4285

1223

53.

EVALUATION OF IN VITRO ANTIOXIDANT CAPACITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF EIGHT DIFFERENT PLANTS MATERIALS

The plants and their materials have been utilized for treatment of various diseases in human and animals which are rich source of antioxidants due to presence of phytonutrients such as vitamins  (alpha- tocopherol, Ascorbate, carotenoid) or minerals (zinc, selenium) and flavanoid, polyphenols and flavoproteins which exert their action through scavenging free radicals in vivo system. Hence search ...

D. K. Sharma *, V. K. Gupta, D. B. Mondal, Mamta Singh, R.S.K. Mandal and R. Raguvaran

Division of Medicine, Indian Veterinary Research Institute, Bareilly (UP), Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(9).4086-91

4086-91

1801

800

54.

EVALUATING HYPOLIPIDEMIC POTENTIAL OF KASNI SEED (CICHORIUM INTYBUS) PREPARATIONS IN NEWLY DIAGNOSED PATIENTS OF METABOLIC DISORDER

Objective: To evaluate hypolipidemic potential of Kasni (Cichorium intybus) seed preparations combined with oral hypoglycemic agent in treatment of patients of newly diagnosed type 2 DM. Methods: Newly diagnosed 90 patients of Type2DM, age 35-65years, of either sex were divided into 3 groups. Each group having 30 patients (19 male and 11 females) matched with each other in terms of age and sex. In...

Praveen Katiyar * , Amod Kumar , Arvind K. Mishra , Rakesh K. Dixit and Ajay K. Gupta

Department of Pharmacology & Therapeutics , King George's Medical University, Lucknow, U.P., India

DOI: 10.13040/IJPSR.0975-8232.6(9).4092-02

4092-02

1805

673