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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 7 (2016) - Issue 8, August

Review Articles

 
Title
Views
PDF
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1.

GREEN FLUORESCENT CARBON DOTS: A NOVEL DRUG TARGETING AND CELL IMAGING AGENT

Nanosized fluorescent carbon particles, carbon dots (CDs), are a kind of fluorescent material that has many applications in recent years. They have biological application like delivery of therapeutic payloads for cancer therapy mainly due to their biocompatibility and unique optical properties. Fluorescent carbon dots overcome the short comings of high toxicity of traditional nano materials. Mor...

D. Kala *, Christy Mary Jolly and P. S. Athiramol

College of Pharmaceutical Sciences, Govt Medical College, Thiruvananthapuram - 695011, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3163-72

3163-72

4415

1482

2.

A REVIEW ON HYPOGLYCAEMIC ACTIVITY OF DIFFERENT EXTRACTS OF VARIOUS MEDICINAL PLANTS

Diabetes mellitus is the common metabolic disorder seen in 2.8% of the world’s population. It is expected to cross 5.4% by 21st century. It is one of the causes of death in this 21st century. Since many years, herbal medicines are used as a source of medicine in Ayurveda and also in some traditional systems of medicine. Ayurveda and other traditional systems have textual evidence about the uses ...

K. Rajya Lakshmi*, M. Supraja, M. Mounika and P. Srinivasa Babu

Vignan Pharmacy College, Vadlamudi, Guntur (Dt), A.P, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3173-84

3173-84

3513

1251

3.

NIGELLA SATIVA SEED, A NOVEL BEAUTY CARE INGREDIENT: A REVIEW

Nigella sativa seed is one of the spices, which is referred by Prophet Mohammed as a herb of blessing, which can cure everything other than death. Therapeutic potential of Nigella sativa seed has been very well studied by many researchers, but its use in cosmetic science is not very well studied. Nigella sativa seed is intensively studied for its chemical composition. It is reported to contains Th...

S. P. Sudhir *, V. O. Deshmukh and H. N. Verma

Department of Life Sciences, Jaipur National University, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3185-96

3185-96

10087

1469

4.

STATIN INDUCED MYOTOXICITY AND ITS CONSEQUENCES – AN OVERVIEW

Statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhibitors, are considered safe in lowering hyperlipidemia and cardiovascular disease. Statin attempt to reduce cholesterol production in liver in dose dependent manner not only cause the muscle related problem but also leads to other untoward consequence like arthritis, diabetes, neurological disorders which arise as a result of scarc...

N. Selvasudha * and Kailasam Koumaravelou

PRIST University, Puducherry campus, Uruvaiyar road, Abishegapakkam, Puducherry. TN, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3197-07

3197-07

3299

878

5.

FUNCTIONALITY TESTING OF EXCIPIENTS: A REVIEW

The quality of medicines depends not only on the active principles and production processes, but also the performance of the excipients, hence we say’ Excipients are Cindrellas of Formulation’. The traditional concept of the excipient as any component other than the active substance has undergone a substantial evolution from an ‘inert’ and cheap vehicle to an essential constituent of the f...

N. D. Derle *, D. V. Derle, M. H. Bele and S. B. Khatale

Department of Pharmaceutics, M.V. Ps College of Pharmacy, Gangapur Road, Nashik, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3208-17

3208-17

4550

915

6.

DERMATOPHYTOSIS: INFECTION AND PREVENTION -A REVIEW

The growing impact of infections caused by dermatophytes i.e. Trichophyton, Microsporum and Epidermophyton is not upto the mark in their treatments via conventional methods due to resistance, side effects, and high toxicity. Over prescription and overuse of traditional antifungal agents, high side effects, less eco-friendly nature, high manufacturing costs, high management costs etc., have stimula...

R. Kumar, S. K. Shukla, A. Pandey, H. Pandey, A. Pathak and A. Dikshit *

Biological Product Laboratory, Botany Department, Faculty of Science, University of Allahabad, Allahabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3218-25

3218-25

4242

1103

7.

SELF EMULSIFYING DELIVERY SYSTEM –MOSTLY DISCUSSED BUT STILL REMAINED CHALLENGING ASPECT TO ENHANCE THE ORAL ABSORPTION OF LIPOPHILIC DRUG

Oral route of drug delivery is the simplest and most accepted way of administration of drugs due to greater stability, high patient compliance, accurate dosage, cost effectiveness and high patient compliance of drugs. But with oral formulations bioavailability is the major problem for newly discovered drug because 40 percent are lipophilic compounds. There are several factors responsible for low o...

Niranjan Chivate *, Kiran Wadkar, Rohit Shah and Anuradha Chivate

Department of Pharmaceutics , KCT’S Krishna College of pharmacy, Karad, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3226-32

3226-32

1845

559

Research Articles

 
Title
Views
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Cited
8.

NOOTROPIC ACTIVITY OF ISORHAMNETIN IN AMYLOID BETA 25-35 INDUCED COGNITIVE DYSFUNCTION AND ITS RELATED mRNA EXPRESSIONS IN ALZHEIMER’S DISEASE

Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer’s disease. The present study was designed to investigate the neuroprotective effects of isorhamnetin (IRN) against amyloid beta 25-35 (Aβ 25-35)-induced memory impairment and oxidative damage in rats. Memory task was assessed using Y-arm maze and it revealed the impairment in spatial memory. The IRN treated ...

Deivasigamani Asha and Thangarajan Sumathi*

Department of Medical Biochemistry, University of Madras, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3233-42

3233-42

2725

761

9.

IN-SILICO PHARMACOPHORE MAPPING AND DOCKING STUDIES OF INDOLE/BENZOXIMIDAZOLE-5-CARBOXIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS

The present research has been focused on the development of pharmacophore mapping and docking studies of indole/benzoximidazole-5-carboximidine derivatives as anti-cancer agents that can explore basic pharmacophore responsible for biological activity of structurally diverse compounds and also their binding affinity to the urokinase-type plasminogen activator (uPA). For pharmacophore mapping, a hig...

S. Agarwal, M. Mishra, V. K. Mishra, D. Vinod , E. Verma and S. K. Kashaw *

Department of Pharmaceutical Sciences, Dr. H.S. Gour Central University, Sagar, MP, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3243-61

3243-61

3365

779

10.

PHYTOCHEMICAL ANALYSIS OF ACTIVE CONSTITUENTS OF ALSTONIA SCHOLARIS AND THEIR CYTOTOXICITY IN VITRO

The non-infected bark of Alstonia scholaris R. Br. was carefully peeled off, shade dried, and coarsely powdered with the help of a hand club. Powdered dried bark was extracted in 95% ethanol at room temperature and evaporated in vacuo (40°C). The ethanolic extract was suspended in distilled water and subsequently extracted in hexane, chloroform, ethyl acetate and n-butanol. The solvent of each fr...

D. Subba Reddy

Department of Pharmacology, Nirmala College of Pharmacy, Atmakuru(v), Mangalagiri(M), Guntur, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3262-73

3262-73

4659

1103

11.

PREDICTION OF CHEMOTHERAPY PRESCRIBING ERRORS FOR ONCOLOGY PATIENTS

The chemotherapy prescribing errors (PEs) can lead to tragic consequences for the oncology patients. This cross-sectional observational study aims to predict the incidence of prescribing errors involving chemotherapeutic agents, and review their severity, through examining a random sample of 500 cancer patients at the out-patient chemotherapy unit of Ain Shams University Hospital, Cairo, Egypt; fr...

H. E. Barakat *, N. A. Sabri and A. S. Saad

Department of Clinical Pharmacy, Faculty of Pharmacy, Ain shams university, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.7(8).3274-83

3274-83

2677

823

12.

HYPOLIPIDEMIC EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA LEAVES ON DYSLIPIDEMIA FOLLOWING HEPATIC INJURY INDUCED BY CARBON TETRACHLORIDE IN ALBINO RATS

Background: The Mimosa pudica, is well known across the world for its different pharmacological activities such as anti diabetic, antitoxin,antioxidant and wound healing activities.In the present study we investigated the hypolipidemic effects of ethanolic extract of leaves of Mimosa pudica linn against dyslipidemia following carbon tetrachloride (CCl4) induced hepatic injury in albino rats. Metho...

Ayan Purkayastha *, Pinaki Chakravarty and Babul Dewan

Department of Pharmacology, Silchar Medical College and Hospital, Silchar, Assam, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3284-90

3284-90

2203

716

13.

DESIGN, SYNTHESIS AND ANTICANCER ACTIVITY OF 9-SUBSTITUTED CARBAZOLE DERIVATIVES

Numerous carbazole derivatives were designed by the Chemsketch software followed by 3D optimization. Docking studies were performed  using AUTODOCK 4.2.6 software to check their binding interactions with eukaryotic topoisomerase-I, based on the crystal structure of Human Topoisomerse-I-DNA complex (PDB ID: 1A35). Results of docking studies of designed carbazole derivatives were compared on the ba...

Nitin Kumar * and Devender Pathak

Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura, UP, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3291-98

3291-98

2236

830

14.

ANTISTRESS ACTIVITY OF DIOSPYROS MALABARICA (DESR.) KOSTEL IN MICE AND RATS

The purpose of this study was to evaluate antistress activity of roots of Diospyros malabarica (Desr.) Kostel (DMDK) against anoxia stress tolerance, chemical induced stress, swimming endurance stress and immobilisation stress models in mice and rats. Ethanolic extract of roots of DMDK (EERDMDK) was screened for its antistress activity at 125 mg/kg, 250 mg/kg, 500 mg/kg, p.o. doses and diazepam wa...

Laxmikant Maruti Purane * and Suryadevera Vidyadhara

Department of Pharmacology, Shivnagar Vidya Prasarak mandal’s, College of Pharmacy, Malegaon Bk, Tal- Baramati, Dist- Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3299-05

3299-05

2145

665

15.

EVALUATION OF BINDING EFFECT OF PROSOPIS CINERARIA LEAF AND STEM BARK EXTRACTS WITH CALF THYMUS DNA

The present research aimed to evaluate the binding effect of hydroalcoholic extracts of leaf and Stem bark of Prosopis cineraria (PCL and PCB) with Calf Thymus (CT) DNA. The interaction of the PCL and PCB with Calf Thymus (CT) DNA has been studied using absorption spectra, viscosity measurements and cyclic voltammetry methods. It was observed that the PCL and PCB exhibited hypochromic and bathochr...

Stellaa Robertson* and N. Narayanan

Department of Pharmacognosy, Jaya College of Paramedical Sciences, College of Pharmacy, Thiruninravur - 602024, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3306-13

3306-13

1628

715

16.

A CASE CONTROL STUDY OF OXIDATIVE STRESS AND INFLAMMATION IN TUNISIAN PATIENTS WITH ISCHEMIC HEART DISEASE

Ischemic heart disease (IHD) is the major cause of morbid-mortality in most countries. The involvement of inflammation and oxidative stress (OS) in the development of atherosclerosis, ischemic cardiopathy triggering phenomen, has been investigated. The high sensitive C-reactive protein (hs_CRP) was measured in serum by immunoenzymatic method. Serum total homocysteine (Hcy) concentration was measur...

S. Khelil *, M. Ben-Hadj-Mohamed , M. Ben Dbibis , L. Khlifi, H. Chahed, S. Ferchichi, S. Ernez and A. Miled

Biochemistry Laboratory, Cardiologylogy Department, Farhat Hached hospital, Sousse, Tunisia

DOI: 10.13040/IJPSR.0975-8232.7(8).3314-21

3314-21

1759

595

17.

SYNTHESIS AND CHARACTERIZATION OF BIOLOGICALLY ACTIVE COMPOUND E-2-((2-AMINO PYRIDINE-3-YL) METHYLENE AMINO) ETHANE THIOL AND ITS METAL COMPLEXES

A new physiologically active compound E-2-((2-amino pyridine-3-yl) methylene amino)ethane thiol derived from the condensation of Cysteamine and 2-amino Pyridine 3-Carbaldehyde was synthesized and characterized by spectral techniques like IR, UV-Vis,1H- NMR, TG-DTA, ESR, CHN analyses. The complexes were further screened for their biological activity at Nishka labs and Nickel and Cobalt complexes we...

A. Khamamkar , S. Gajula and V. R. Pallapothula *

Department of chemistry, University college of Science, O.U, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3322-29

3322-29

1738

580

18.

ANTICANCER ACTIVITY OF CALOPHYLLUM INOPHYLLUM L., ETHANOLIC LEAF EXTRACT IN MCF HUMAN BREAST CELL LINES

Cancer is a major health problem; almost thought - out the world. Herbal medicines have a vital role in the prevention and treatment of cancer. The present study, the in vitro anticancer activity of Calophyllum inophyllum ethanolic leaf extract was evaluated in MCF-7 Breast cancer cell lines. Anticancer activity was evaluated with MTT standard colorimetric assay against MCF-7 cells with IC50 value...

K. Jaikumar, Sheik Noor Mohamed M., Anand D and P. Saravanan *

Department of Botany, Ramakrishna Mission Vivekananda College, Mylapore, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3330-35

3330-35

3065

786

19.

CRISPR/Cas9 TECHNOLOGY- A NEW BOON IN GENOME EDITING

Targeted genome engineering provides the ability to precisely modify genetic information in order to study gene function, biological mechanisms, and disease pathology. Historically, random mutagenesis or low-efficiency homologous recombination were used to modify the genomes of cell lines or animal models. However, new advances in the design of sequence-specific endonucleases have enabled more eff...

Fathima Benazir * and Gowlikar Abhinayani

Department of Pharmaceutics, Department of Pharmacology, Geethanjali college of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.7(8).3336-47

3336-47

2619

758

20.

THROMBOLYTIC POTENTIAL OF PUNICA GRANATUM – A STUDY IN THE RAT MODEL

Although the antioxidant and thrombolytic potential of the “super fruit” pomegranate has been well established and documented in in vitro models, its efficacy in an animal model has not been recognised. Therefore in the present study, the aril and rind of Punica granatum were scrutinized for their role in clot lysing competence in a thrombus induced rat model. Visual manifestation, coagulation...

Shalini H. Kumar and A. Pushpa *

Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3348-54

3348-54

1597

621

21.

ASSESSMENT AND COMPARISON OF EFFICACY OF MIDAZOLAM AND DIAZEPAM AS PREOPERATIVE MEDICATION

Objective: To compare the drugs: Midazolam and diazepam as preoperative medication. Materials and methods: 100 patients aged between 18-60, scheduled for elective surgery were included in this comparative study. Patients were randomly allocated into two groups of 50 each. Materials and methods: Patients received 0.08mg/kg body weight midazolam inject intramuscularly and diazepam 10 mg orally. Asse...

Sashi Kandel* and Rudip Thapa

Department of Pharmacology, Kantipur Dental College & Research Centre, Basundhara, Kathmandu, Nepal

DOI: 10.13040/IJPSR.0975-8232.7(8).3355-60

3355-60

3022

584

22.

IMPACT OF LABOR RIGHTS ON JORDANIAN PHARMACISTS’ SATISFACTION

Background: Pharmacists’ jobs in Jordan are important and contribute to the welfare of patients and citizens. Through interviews of a number of pharmacists it was felt that there is need to study their feelings about their rights and satisfaction. Objectives: The aim of this study is to measure the perceptions of Jordanian pharmacists on attaining their rights, and the impact of these rights on ...

M. A. Abujarad Alhuwitat *, M. S. Abu- Salih and M. M. Eseid

Department of Business Administration, Amman Arab University, Amman, Jordan

DOI: 10.13040/IJPSR.0975-8232.7(8).3361-65

3361-65

1777

585

23.

PHYTOTOXICITY OF CITRUS FRUIT WASTE AGAINST HUMAN PATHOGENIC BACTERIA

The main objective of this study is to evaluate the antibacterial activity and phytochemical analysis of Lemon (Citrus limon L.) and Orange (Citrus sinensis L.) Increasing resistance of microorganisms to present day antibiotics arose a way to focus on antimicrobial activity and future prophylactic potential of the lemon and orange peels. In the present study, a total of two extract each of Methano...

Anshu Singh*, J.N. Srivastava and Anil Kumar

Department of Botany, Dayalbagh Educational Institute, Agra, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3366-72

3366-72

1806

574

24.

EFFECT OF CAMELLIA SINENSIS EXTRACTS ON GROWTH OF VIRULENT GRAM NEGATIVE UROPATHOGENS

Urinary tract infections causing bacteria play an important role in expression and spread of drug resistance among bacteria in the hospitals and in community. Because of rapid increase in antibiotic resistance, alternative antimicrobial agents are needed to be developed and employed to control multi-drug resistant bacteria. The present study focuses on antibacterial activity of Green and Black tea...

Vishaka Labar, Rinzi Bhutia and Y.V.S. Annapurna*

Department of Microbiology, St. Francis College for Women, Begumpet, Hyderabad, Telangana India

DOI: 10.13040/IJPSR.0975-8232.7(8).3373-78

3373-78

2320

614

25.

INHIBITION OF SPERMATOGENESIS WITH THE TREATMENT OF 50% METHANOLIC EXTRACT OF MAYTENUS EMARGINATA LEAVES IN ALBINO RATS

The plant Maytenus emarginata belongs to the Family Celastraceae also known as Kankhera in     Hindi have used effectively for the treatment of wide range of disorder as digestive ailments, nerve afflictions, Heart ailments, inflammation, nervous system, Rashes and as a tonic and anti stress. The present investigation is planned to evaluate safety and reversible contraceptive efficacy of aqueo...

Deepak Kumar Sharma and Pratap Chand Mali*

Reproductive Biomedicine and Natural Products Lab, Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3379-87

3379-87

1744

667

26.

COMPARATIVE EVALUATION OF HEPATOPROTECTIVE EFFECTS OF EXOTIC FRUITS AND COMMON VEGETABLES EXTRACTS ON CCL4 INDUCED HEPATOTOXICITY: AN IN VITRO STUDY

Liver toxicity faces a major challenge in world health issues. Many drugs are being withdrawn from the market by Food and Drug Administration (FDA) for causing drug induced hepatotoxicity. In the present study, ameliorative activity of methanoic extracts of different parts (Peel, Pulp and seed) of exotic fruits and vegetables on carbon tetrachloride (CCl4)-induced hepatotoxicity were studied in in...

Kavitha Raj V., J. R. Kumar *, S. Balasubramanian, S. Najunda Swamy, D. Keerthini, N. Shambhavi, B. M. Kanthesh and K. O. Avinash

Division of Biochemistry, Faculty of Life Science, JSS University, Mysuru, Karnataka India

DOI: 10.13040/IJPSR.0975-8232.7(8).3388-93

3388-93

2048

603

27.

FORMULATION DEVELOPMENT AND EVALUATION OF ACECLOFENAC MICROEMULSION

The aim of my present study is to Develop and Evaluate Microemulsion for topical application of Aceclofenac by using oleic acid at different ratios for the treatment of pain. Microemulsion was prepared by water trituration method using oleic acid as oil phase, tween-80 as surfactant and polyethylen glycol-400 as co-surfactant. Different oils, surfactants and co-surfactants were screened to select ...

Brahmaiah Bonthagarala*, Venkatesh Murukutla and Manohar Babu S.

Department of Pharmaceutics, SIMS College of Pharmacy, SIMS Group of Institutions, Mangaldas Nagar, Guntur,-522001, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3394-05

3394-05

2537

780

28.

PROTECTIVE EFFECT OF CAESALPINIA BONDUCELLA (LINN.) SEED KERNEL EXTRACT IN STREPTOZOTOCIN-INDUCED HYPERGLYCAEMIA AND OXIDATIVE DAMAGE IN WISTAR RATS

Evidence implicates hyperglycemia induced oxidative stress as a key factor in the pathogenesis of both microvascular and macrovascular complications in the body. Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia and oxidative damage in rats. Rats were made hyperglycemic by single intraven...

Mohammad Ahmad *, Deeba Shamim Jairajpuri, Vidhu Aeri , Zeeba Shamim Jairajpuri , Md. Shamim Akhter , Moon Jain and Manju Sharma

Faculty of Pharmacy, Integral University, Lucknow,, UP, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3406-22

3406-22

2624

750

29.

SEPARATION AND CHARACTERIZATION OF TRITERPENE COMPOUND EUPHOL FROM THE LEAVES OF AZIMA TETRACANTHA

Azima tetracantha is a small flowering shrub belongs to salvadoraceae family and commonly known as mulluchangu or mulsangu in Tamil. It is an best known medicinal plant ,which  have a central role in the treatment of disease from pre historical period. From the plant lot of phytochemicals has been reported  such as alkaloids, steroids ,tannins, terpenoids, flavonoids, glycosides, phenols  etc ...

C. Kavitha * and V. Sandhiya

Department of Pharmacognosy, C.L. Baid Metha College of Pharmacy, Chennai, Tamil nadu, India

DOI: 10.13040/IJPSR.0975-8232.7(7).3423-27

3423-27

1662

703

30.

AUTHENTICATION OF MORPHOLOGICALLY SIMILAR RHIZOME DRUGS BASED ON TLC FINGERPRINT PROFILES AND VALERENIC ACID CONTENT

Objective: Present study involved comparison of thin layer chromatograms and quantification of valerenic acid (VA) in four morphologically similar rhizome drugs – Valeriana jatamansi, Nordostachys jatamansi, Selinum vaginatum and Ferula sumbul. Materials and methods: Ethanol extract of the four drugs were prepared under standard conditions and VA content was determined using TLC densitometry. Re...

Sonali Batra, Ashwani Kumar* and Anupam Sharma

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3428-31

3428-31

1743

711

31.

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF NYMPHAEA ALBA

Hyperlipidemia is the greatest risk factor of coronary heart disease, currently available hypolipidemic drugs have been associated with number of side effects. Literature claims that flavonoids are able to reduce hyperlipidemia. Based on high flavonoids content in herbal plants, Nymphaea alba (NA) family Nymphaeaceae were selected and the present study focus on the antihyperlipidemic activity of m...

N. Jaya Raju *, B. Satya Vani , G. Santhi , L. Lavanya and T. Chandi Vishala

Adarsa College of Pharmacy 1, G. Kothapalli, Gokavaram(m), East Godavari dt, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3432-35

3432-35

2002

627

32.

EVALUATION OF PHYTOCHEMICALS, REDUCING POWER, ANTIOXIDANT ACTIVITY AND IN-VITRO LIPID PEROXIDATION ACTIVITY OF WHEAT GRASS JUICE

Oxidative stress is a condition due to excessive production of free radicals than the ability of the antioxidant system to counteract them. Antioxidants scavenge and suppress the deleterious effects of free radicals. Both exogenous and endogenous sources of antioxidants are important in pathological conditions. Exogenous antioxidants include dietary sources and even include medicinal plants. These...

S. N. Jangle and P. Padmanabhan *

Department of Biochemistry, Rural Medical College, Pravara Institute of Medical Sciences (DU), Loni , Ahmednagar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(8).3436-40

3436-40

1605

580

33.

DEVELOPMENT AND VALIDATIONRP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINETION OF LOPERAMIDE HYDROCHLORIDE AND NORFLOXACIN IN PHARMACEUTICAL FORMULATION

A reverse-phase liquid chromatographic (RP-HPLC) method was developed for the determinations of loperamide hydrochloride and norfloxacin in their marketed formulation and bulk. The separation was carried out using mobile phase of triethylamine and acetonitrile (50:50%) with pH 4.The pH adjusted with orthophosphoric acid. The column used was Capcell pack C18 Column (250mn x 4.6mm, 5mm) and flow rat...

A. M. Sonawane *, P. B. Dudhe, N. H. Chalke and K. B. Bhagat

Department of Quality Assurance Techniques, Sinhgad College of Pharmacy, Vadgaon (Bk), Pune- 411041, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(8).3441-45

3441-45

2742

891

34.

ISOLATION AND DEVELOPMENT OF AN HPLC METHOD FOR THE QUANTIFICATION OF A BIOMARKER IN THE ROOTS OF PAULLINIA PINNATA

An RP-HPLC method to be used to quantitate the amount of a biomarker in the roots of Paullinia pinnata was developed. The root bark was milled and extracted and the dry powder obtained taken through column chromatography (CC). The biomarker was then isolated. The melting point of the biomarker was determined and found to be 117-119 oC. A RP-HPLC method was successfully developed and used to quanti...

E. K. Cudjoe , John N. A. Addotey *, Nathaniel N. A. Okine , Reimmel K. Adosraku, Kofi Annan

Department of Pharmaceutical Chemistry *, KNUST, Kumasi, Ghana. KNUST, Kumasi, Ghana.

DOI: 10.13040/IJPSR.0975-8232.7(8).3446-52

3446-52

1805

587

35.

AN UPDATE ON MORPHOMETRY OF HUMAN PARATHYROID GLAND– A POSTMORTEM STUDY

A collective assessment of all the morphometric measurements like size, weight, color and shape of the parathyroid gland is important in the determination of its normalcy. After that the histological examination for stromal and intracellular fatty content helps to determine the normalcy of the gland. There have been several studies on morphology of human parathyroid gland, but the grand total of c...

Swati Bansal *, I. Kayalvizhi, Priyanka , Rajiv Jain, Vipin Jain and Sarvottama Antil

Department of Anatomy, HIMS, Kaithal, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3453-57

3453-57

1688

570

36.

PATTERN & PREDICTORS OF DRUG-DRUG INTERACTIONS AMONG THE PATIENTS ADMITTED IN NEUROLOGY AT A TERTIARY CARE HOSPITAL – A CROSS-SECTIONAL STUDY

Objective: Drug - drug interactions (DDI) is a permanent risk in patients with complex therapeutic regimens. Drugs commonly prescribed in Neurology contribute for most of the potentially hazardous DDI. The present study was undertaken to identify the DDI and its predictors among the patients admitted in Neurology ward. Material and Methods: An analytical cross-sectional study was conducted from Ja...

Debdipta Bose* and M. Sushma

Department of Pharmacology, Bangalore Medical College & Research Institute, KR Road, Bengaluru, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3458-64

3458-64

1915

557

37.

STUDY OF PRESCRIBED DOSE CALCULATION IN PEDIATRIC PATIENTS

Background: Pediatrics pose a unique set of risks of medication errors, predominantly because of the need to make dosage calculations, which are individually based on the patient’s weight, age or body surface area (BSA), and their condition. This increases the likelihood of errors, particularly dosing errors. In particular; preventing dosing errors is an important part of ensuring safe and quali...

N. D. Tank *, N. B. Bhansali and B. N. Karelia

Department of Pharmacology, P.D.U. Govt. Medical College, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.7(8).3465-71

3465-71

3359

877

38.

PHYTOCHEMICAL ANALYSIS AND ANTITUBERCULAR ACTIVITY OF FLOWERS EXTRACT OF MANGIFERA INDICA

About 5 extract (hexane, acetone, ethanol, methanol, aqueous extraction) from the flowers of Mangifera indica was extracted. Ethanol extract was characterized by Gas Chromatography-Mass Spectroscopy. Seven constituents from 7 peaks were identified. Icosanedioic acid monomethyl ester, nonadec-16-enyl-benzene, 1, 9 diphenyl nonane, icosane, octadecane, dodecanoic acid butyl ester, tetracosyl- benzen...

Naveen K. Karumanchi*, Bhagwan S. Gupta, Darshana Mehta and Bhupendra K. Mehta

Laboratory of Natural products, School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3472-76

3472-76

2267

917

39.

EFFECT OF HYDROSOL OF IPOMEA CARNEA LEAVES, FLOWERS AND LANTANA CAMERA LEAVES ON THE GROWTH OF WHEAT, MAIZE AND COTTON PLANT

The Wheat, Maize and Cotton are the major crops in the agriculture field specially in Maharashtra, India. So for better productivity this study aims to prepare steam soluble aroma compounds called hydrosols. Hydrosols of different plant species (Ipomea carnea Leaves and Flowers, Lantana Camera Leaves) were prepared by steam distillation method. The purpose of this study was to determine the effect...

V. B. Suradkar *, B. B. Wankhade, R. G. Talreja, M. S. Talreja and P. D. Ochani

Department of Chemistry, Vidnyan Mahavidyalaya Malkapur, Dist-Buldana, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.7(8).3477-79

3477-79

2059

587

40.

IMPACT OF AN EDUCATIONAL INTERVENTION ON ASTHMA KNOWLEDGE AND METERED-DOSE INHALER TECHNIQUE AMONG NURSING STUDENTS OF GOVERNMENT COLLEGE OF NURSING, BENGALURU

Nurses being one of the important members of the healthcare team, play a significant role in providing care and education. Current effective treatments for asthma are in the form of metered-dose inhalers. An effective control is achieved only when the patient is comfortable to use the metered-dose inhaler device correctly. This study was therefore planned to evaluate their knowledge and to assess ...

G. M. Roopavathy *, P. Panchaksharimath and M. Sushma

Department Of Pharmacology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3480-85

3480-85

2111

566

41.

A COMPARATIVE STUDY OF EFFECT OF INTRAVENOUS DEXMEDETOMIDINE VS. PLACEBO BEFORE BRACHIAL PLEXUS BLOCK ON PATIENT SATISFACTION AND SUCCESS OF BLOCK

The brachial plexus block(BPB) has gained importance as regional anaesthetic technique for upper limb surgery. The primary aim of our study was to evaluate the addition of intravenous dexmedetomidine before BPB on overall patient satisfaction and sucess with objective of comparing the onset and duration of block, haemodynamic stability and sedation score. A randomized double blind prospective stud...

R. Singapura, K. Dalvani, C. Jadeja*, S. Majhi and J. Patel

Department of Anesthesiology, P.D.U. Govt. Medical College and Hospital, Rajkot, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3486-92

3486-92

4084

592

42.

A RETROSPECTIVE STUDY OF MALARIA FROM WESTERN PART OF UTTAR PRADESH, INDIA

Background: Malaria is a serious parasitic health problem in India. Plasmodium vivax and falciparum pose the greatest public challenge in endemic areas. P. vivax accounts for more than half of all malaria cases. Accurate and prompt diagnosis is not only important to prevent morbidity, but also helps minimizing drug resistance. Aim: To know the profile of malaria parasite in the patients attending ...

Dharmendra Prasad Singh *, Rajesh Kumar Verma, Amit Singh, Sunita Kumari and M. E. Siddique

Department of Microbiology, UPRIMS and R, Saifai, Etawah, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(8).3493-96

3493-96

2278

639

43.

DRUG UTILISATION PATTERN OF PSYCHOTROPIC DRUGS IN PSYCHIATRIC OUTPATIENT DEPARTMENT OF RURAL TERTIARY CARE TEACHING HOSPITAL

Background: Psychiatric disorders are one of the major causes of morbidity. Development of newer drugs like selective serotonin reuptake inhibitors and atypical antipsychotics has altered the treatment paradigms. Objective: To study drug utilization pattern of psychotropic drugs in psychiatric outpatient department. Material and Methods: After ethical approval six month observational, prospective ...

M. Kumara Swamy, Laxman Wagle * and Vivek Giri

Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Rajiv Gandhi University of health Science, Nagamangala -Taluk Mandya, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3497-08

3497-08

2623

844

44.

A STUDY TO EVALUATE USAGE OF ANTIMICROBIAL AGENTS AT PRIMARY HEALTH CENTRES AND URBAN HEALTH CENTRES IN AHMEDABAD DISTRICT

Aims and Objectives: To evaluate the use and the impact of interventions on the use of antimicrobial agents (AMAs) at Primary Health Centres (PHCs) and Urban Health Centres (UHCs) in Ahmedabad district. Materials and methods: This was an interventional and prospective study carried out at 5 PHCs and 5 UHCs of ahmedabad district. In pre-intervention phase, 30 adult patients from each centre who wer...

A. K. Chauhan *, P. P. Patel, A. M. Gandhi, M. K. Desai and R. K. Dikshit

Department of Pharmacology, Smt Kashibai Navale Medical College, Narhe, Pune, MH, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3509-16

3509-16

1613

540

45.

EFFICACY AND SAFETY OF AGOMELATINE IN TREATMENT OF MAJOR DEPRESSIVE DISORDER: A PILOT STUDY

Back ground: Agomelatine is a novel antidepressant which acts through a combination of agonistic actions at MT1 and MT2 subtypes of  Mela­tonergic receptors and antagonistic actions at 5-HT2C subtype of serotonergic receptors. Objective: The study was carried out to evaluate the efficacy and safety of Agomelatine in the treatment of Major depressive disorder. Method: A prospective study  was co...

Srikrishna Nukala *, Ravi Babu Komaram , Jayasree Palla and Murthy KSN

Department of Psychiatry, GITAM Institute of Medical Sciences and Research, Visakhapatnam, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3517-21

3517-21

2346

922

46.

PHYTOCHEMICAL SCREENING AND CHROMATOGRAPHIC EVALUATION OF FICUS BENGHALENSIS LEAVES

Aim: To rationalize the macroscopial, anatomical and physico- chemical studies on leaves of Ficus benghalensis (Maraceae). Materials & methods: The crude ethanolic extract of leaves of Ficus benghalensis (Maraceae) was using Physico-chemical parameters, and Preliminary photochemical investigation (TLC, HPTLC, & Column Chrmatography). Results and conclusion: An attempt had been made to high...

S. Chaudhary *, S. Alok and A. Verma

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, UP, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3522-32

3522-32

4010

783

47.

IMMUNOLOGICAL AND BIOCHEMICAL CHARACTERIZATION OF GLUTATHIONE-S-TRANSFERASE IN PARTHENIUM POLLINOSIS AND ITS CROSS-REACTIVITY WITH BIRCH POLLINOSIS FOR CLINICAL RELEVANCE

Pollinosis is one of the most common allergic diseases in Asia, Central and Northern Europe as well as in North America. Several proteins in parthenium pollen have already been characterized as allergens causing sensitization and the development of allergic symptoms in atopic individuals. Glutathione-S-transferase are a phylogenetically widespread enzyme family mainly involved in cellular detoxifi...

Praveen Kumar Vemuri *, Bhavana Talluri and Gayathri Panangipalli

Centre for Genomics and Proteomics, Department of Biotechnology, K L University, Vaddeswaram, Guntur District, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3533-38

3533-3538

1534

509

48.

EVALUATION OF MACROSCOPICAL AND MICROSCOPICAL STUDY, PHYTOCHEMICAL ANALYSIS, TLC AND HPTLC FINGERPRINTING OF BAUHINIA PURPUREA LINN. LEAVES

Objective- To rationalize the Macroscopical and Microscopical study, Phytochemical analysis, TLC and HPTLC fingerprinting of Bauhinia purpurea Linn. Leaves. Methods- The crude ethanolic extract of leaves of Bauhinia purpurea Linn. was using the macroscopical characters (size, shape, colour, odour, taste, surface, texture, venation, margin, base, and petiole) powder microscopical study, the powder ...

D. K. Chanchal*, P. S. Niranjan, S. Alok and S. Rashi

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), India.

DOI: 10.13040/IJPSR.0975-8232.7(8).3539-44

3539-44

2247

673

49.

STUDY OF THE EFFECT OF MELATONIN ON RETENTION OF CONDITIONED AVOIDANCE RESPONSE AND ON ENHANCEMENT OF SEROTONIN MEDIATED BEHAVIOURAL RESPONSES AFTER ELECTROCONVULSIVE SHOCK (ECS) ADMINISTRATION IN RATS

Objectives: To obtain the data regarding the effects of melatonin on retention of conditioned avoidance response (CAR) and on enhancement of serotonin mediated behavioural responses after electroconvulsive shock (ECS) administration in rats. Methods: Forty rats after training for conditioned avoidance response by using Cook’s pole climbing apparatus were divided in four groups with ten rats in e...

Jeetendra Singh, Tushar Chandrakant Baheti * and Sameer Balasaheb Dharrao

Assistant Professor, Department of Pharmacology, Assistant Professor, Department of Pharmacology, Dr. Vasamtrao Pawar Medical College, Hospital & Research centre, Vasantdada Nagar, Adgaon, Nashik- 422003 Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3545-49

3545-49

1642

515

50.

AMELIORATIVE EFFECT OF CURCUMIN ON PROFENOFOS INDUCED OXIDATIVE DAMAGE OF RENAL TISSUE IN MICE

The aim of the present study is to evaluate the ameliorative effect of curcumin against profenofos induced oxidative damage of renal tissue in mice. Animals were divided into four different groups namely Group-I (control mice; NC), Group-II (NC gavaged 100µl ethanol for 30 days; EC), Group-III (NC gavaged 25mg/kg b.w profenofos for alternate 30 days; PC) and Group-IV (PC treated with 120mg/kg b.w...

J. K. Singh, A. K. Roy and Pranay P. Pankaj*

Department of Zoology, Nagaland University, Lumami, Nagaland, 798627, India.

DOI: 10.13040/IJPSR.0975-8232.7(8).3550-56

3550-56

1420

586