Volume 7 (2016) - Issue 8, August
Nanosized ﬂuorescent carbon particles, carbon dots (CDs), are a kind of ﬂuorescent material that has many applications in recent years. They have biological application like delivery of therapeutic payloads for cancer therapy mainly due to their biocompatibility and unique optical properties. Fluorescent carbon dots overcome the short comings of high toxicity of traditional nano materials. Mor...
Diabetes mellitus is the common metabolic disorder seen in 2.8% of the world’s population. It is expected to cross 5.4% by 21st century. It is one of the causes of death in this 21st century. Since many years, herbal medicines are used as a source of medicine in Ayurveda and also in some traditional systems of medicine. Ayurveda and other traditional systems have textual evidence about the uses ...
Nigella sativa seed is one of the spices, which is referred by Prophet Mohammed as a herb of blessing, which can cure everything other than death. Therapeutic potential of Nigella sativa seed has been very well studied by many researchers, but its use in cosmetic science is not very well studied. Nigella sativa seed is intensively studied for its chemical composition. It is reported to contains Th...
Statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhibitors, are considered safe in lowering hyperlipidemia and cardiovascular disease. Statin attempt to reduce cholesterol production in liver in dose dependent manner not only cause the muscle related problem but also leads to other untoward consequence like arthritis, diabetes, neurological disorders which arise as a result of scarc...
The quality of medicines depends not only on the active principles and production processes, but also the performance of the excipients, hence we say’ Excipients are Cindrellas of Formulation’. The traditional concept of the excipient as any component other than the active substance has undergone a substantial evolution from an ‘inert’ and cheap vehicle to an essential constituent of the f...
The growing impact of infections caused by dermatophytes i.e. Trichophyton, Microsporum and Epidermophyton is not upto the mark in their treatments via conventional methods due to resistance, side effects, and high toxicity. Over prescription and overuse of traditional antifungal agents, high side effects, less eco-friendly nature, high manufacturing costs, high management costs etc., have stimula...
SELF EMULSIFYING DELIVERY SYSTEM –MOSTLY DISCUSSED BUT STILL REMAINED CHALLENGING ASPECT TO ENHANCE THE ORAL ABSORPTION OF LIPOPHILIC DRUG
Oral route of drug delivery is the simplest and most accepted way of administration of drugs due to greater stability, high patient compliance, accurate dosage, cost effectiveness and high patient compliance of drugs. But with oral formulations bioavailability is the major problem for newly discovered drug because 40 percent are lipophilic compounds. There are several factors responsible for low o...
NOOTROPIC ACTIVITY OF ISORHAMNETIN IN AMYLOID BETA 25-35 INDUCED COGNITIVE DYSFUNCTION AND ITS RELATED mRNA EXPRESSIONS IN ALZHEIMER’S DISEASE
Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer’s disease. The present study was designed to investigate the neuroprotective effects of isorhamnetin (IRN) against amyloid beta 25-35 (Aβ 25-35)-induced memory impairment and oxidative damage in rats. Memory task was assessed using Y-arm maze and it revealed the impairment in spatial memory. The IRN treated ...
IN-SILICO PHARMACOPHORE MAPPING AND DOCKING STUDIES OF INDOLE/BENZOXIMIDAZOLE-5-CARBOXIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS
The present research has been focused on the development of pharmacophore mapping and docking studies of indole/benzoximidazole-5-carboximidine derivatives as anti-cancer agents that can explore basic pharmacophore responsible for biological activity of structurally diverse compounds and also their binding affinity to the urokinase-type plasminogen activator (uPA). For pharmacophore mapping, a hig...
The non-infected bark of Alstonia scholaris R. Br. was carefully peeled off, shade dried, and coarsely powdered with the help of a hand club. Powdered dried bark was extracted in 95% ethanol at room temperature and evaporated in vacuo (40°C). The ethanolic extract was suspended in distilled water and subsequently extracted in hexane, chloroform, ethyl acetate and n-butanol. The solvent of each fr...
The chemotherapy prescribing errors (PEs) can lead to tragic consequences for the oncology patients. This cross-sectional observational study aims to predict the incidence of prescribing errors involving chemotherapeutic agents, and review their severity, through examining a random sample of 500 cancer patients at the out-patient chemotherapy unit of Ain Shams University Hospital, Cairo, Egypt; fr...
HYPOLIPIDEMIC EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA LEAVES ON DYSLIPIDEMIA FOLLOWING HEPATIC INJURY INDUCED BY CARBON TETRACHLORIDE IN ALBINO RATS
Background: The Mimosa pudica, is well known across the world for its different pharmacological activities such as anti diabetic, antitoxin,antioxidant and wound healing activities.In the present study we investigated the hypolipidemic effects of ethanolic extract of leaves of Mimosa pudica linn against dyslipidemia following carbon tetrachloride (CCl4) induced hepatic injury in albino rats. Metho...
Numerous carbazole derivatives were designed by the Chemsketch software followed by 3D optimization. Docking studies were performed using AUTODOCK 4.2.6 software to check their binding interactions with eukaryotic topoisomerase-I, based on the crystal structure of Human Topoisomerse-I-DNA complex (PDB ID: 1A35). Results of docking studies of designed carbazole derivatives were compared on the ba...
The purpose of this study was to evaluate antistress activity of roots of Diospyros malabarica (Desr.) Kostel (DMDK) against anoxia stress tolerance, chemical induced stress, swimming endurance stress and immobilisation stress models in mice and rats. Ethanolic extract of roots of DMDK (EERDMDK) was screened for its antistress activity at 125 mg/kg, 250 mg/kg, 500 mg/kg, p.o. doses and diazepam wa...
The present research aimed to evaluate the binding effect of hydroalcoholic extracts of leaf and Stem bark of Prosopis cineraria (PCL and PCB) with Calf Thymus (CT) DNA. The interaction of the PCL and PCB with Calf Thymus (CT) DNA has been studied using absorption spectra, viscosity measurements and cyclic voltammetry methods. It was observed that the PCL and PCB exhibited hypochromic and bathochr...
A CASE CONTROL STUDY OF OXIDATIVE STRESS AND INFLAMMATION IN TUNISIAN PATIENTS WITH ISCHEMIC HEART DISEASE
Ischemic heart disease (IHD) is the major cause of morbid-mortality in most countries. The involvement of inflammation and oxidative stress (OS) in the development of atherosclerosis, ischemic cardiopathy triggering phenomen, has been investigated. The high sensitive C-reactive protein (hs_CRP) was measured in serum by immunoenzymatic method. Serum total homocysteine (Hcy) concentration was measur...
SYNTHESIS AND CHARACTERIZATION OF BIOLOGICALLY ACTIVE COMPOUND E-2-((2-AMINO PYRIDINE-3-YL) METHYLENE AMINO) ETHANE THIOL AND ITS METAL COMPLEXES
A new physiologically active compound E-2-((2-amino pyridine-3-yl) methylene amino)ethane thiol derived from the condensation of Cysteamine and 2-amino Pyridine 3-Carbaldehyde was synthesized and characterized by spectral techniques like IR, UV-Vis,1H- NMR, TG-DTA, ESR, CHN analyses. The complexes were further screened for their biological activity at Nishka labs and Nickel and Cobalt complexes we...
ANTICANCER ACTIVITY OF CALOPHYLLUM INOPHYLLUM L., ETHANOLIC LEAF EXTRACT IN MCF HUMAN BREAST CELL LINES
Cancer is a major health problem; almost thought - out the world. Herbal medicines have a vital role in the prevention and treatment of cancer. The present study, the in vitro anticancer activity of Calophyllum inophyllum ethanolic leaf extract was evaluated in MCF-7 Breast cancer cell lines. Anticancer activity was evaluated with MTT standard colorimetric assay against MCF-7 cells with IC50 value...
Targeted genome engineering provides the ability to precisely modify genetic information in order to study gene function, biological mechanisms, and disease pathology. Historically, random mutagenesis or low-efficiency homologous recombination were used to modify the genomes of cell lines or animal models. However, new advances in the design of sequence-specific endonucleases have enabled more eff...
Although the antioxidant and thrombolytic potential of the “super fruit” pomegranate has been well established and documented in in vitro models, its efficacy in an animal model has not been recognised. Therefore in the present study, the aril and rind of Punica granatum were scrutinized for their role in clot lysing competence in a thrombus induced rat model. Visual manifestation, coagulation...
Objective: To compare the drugs: Midazolam and diazepam as preoperative medication. Materials and methods: 100 patients aged between 18-60, scheduled for elective surgery were included in this comparative study. Patients were randomly allocated into two groups of 50 each. Materials and methods: Patients received 0.08mg/kg body weight midazolam inject intramuscularly and diazepam 10 mg orally. Asse...
Background: Pharmacists’ jobs in Jordan are important and contribute to the welfare of patients and citizens. Through interviews of a number of pharmacists it was felt that there is need to study their feelings about their rights and satisfaction. Objectives: The aim of this study is to measure the perceptions of Jordanian pharmacists on attaining their rights, and the impact of these rights on ...
The main objective of this study is to evaluate the antibacterial activity and phytochemical analysis of Lemon (Citrus limon L.) and Orange (Citrus sinensis L.) Increasing resistance of microorganisms to present day antibiotics arose a way to focus on antimicrobial activity and future prophylactic potential of the lemon and orange peels. In the present study, a total of two extract each of Methano...
Urinary tract infections causing bacteria play an important role in expression and spread of drug resistance among bacteria in the hospitals and in community. Because of rapid increase in antibiotic resistance, alternative antimicrobial agents are needed to be developed and employed to control multi-drug resistant bacteria. The present study focuses on antibacterial activity of Green and Black tea...
INHIBITION OF SPERMATOGENESIS WITH THE TREATMENT OF 50% METHANOLIC EXTRACT OF MAYTENUS EMARGINATA LEAVES IN ALBINO RATS
The plant Maytenus emarginata belongs to the Family Celastraceae also known as Kankhera in Hindi have used effectively for the treatment of wide range of disorder as digestive ailments, nerve afflictions, Heart ailments, inflammation, nervous system, Rashes and as a tonic and anti stress. The present investigation is planned to evaluate safety and reversible contraceptive efficacy of aqueo...
COMPARATIVE EVALUATION OF HEPATOPROTECTIVE EFFECTS OF EXOTIC FRUITS AND COMMON VEGETABLES EXTRACTS ON CCL4 INDUCED HEPATOTOXICITY: AN IN VITRO STUDY
Liver toxicity faces a major challenge in world health issues. Many drugs are being withdrawn from the market by Food and Drug Administration (FDA) for causing drug induced hepatotoxicity. In the present study, ameliorative activity of methanoic extracts of different parts (Peel, Pulp and seed) of exotic fruits and vegetables on carbon tetrachloride (CCl4)-induced hepatotoxicity were studied in in...
The aim of my present study is to Develop and Evaluate Microemulsion for topical application of Aceclofenac by using oleic acid at different ratios for the treatment of pain. Microemulsion was prepared by water trituration method using oleic acid as oil phase, tween-80 as surfactant and polyethylen glycol-400 as co-surfactant. Different oils, surfactants and co-surfactants were screened to select ...
PROTECTIVE EFFECT OF CAESALPINIA BONDUCELLA (LINN.) SEED KERNEL EXTRACT IN STREPTOZOTOCIN-INDUCED HYPERGLYCAEMIA AND OXIDATIVE DAMAGE IN WISTAR RATS
Evidence implicates hyperglycemia induced oxidative stress as a key factor in the pathogenesis of both microvascular and macrovascular complications in the body. Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia and oxidative damage in rats. Rats were made hyperglycemic by single intraven...
Azima tetracantha is a small flowering shrub belongs to salvadoraceae family and commonly known as mulluchangu or mulsangu in Tamil. It is an best known medicinal plant ,which have a central role in the treatment of disease from pre historical period. From the plant lot of phytochemicals has been reported such as alkaloids, steroids ,tannins, terpenoids, flavonoids, glycosides, phenols etc ...
AUTHENTICATION OF MORPHOLOGICALLY SIMILAR RHIZOME DRUGS BASED ON TLC FINGERPRINT PROFILES AND VALERENIC ACID CONTENT
Objective: Present study involved comparison of thin layer chromatograms and quantification of valerenic acid (VA) in four morphologically similar rhizome drugs – Valeriana jatamansi, Nordostachys jatamansi, Selinum vaginatum and Ferula sumbul. Materials and methods: Ethanol extract of the four drugs were prepared under standard conditions and VA content was determined using TLC densitometry. Re...
Hyperlipidemia is the greatest risk factor of coronary heart disease, currently available hypolipidemic drugs have been associated with number of side effects. Literature claims that flavonoids are able to reduce hyperlipidemia. Based on high flavonoids content in herbal plants, Nymphaea alba (NA) family Nymphaeaceae were selected and the present study focus on the antihyperlipidemic activity of m...
EVALUATION OF PHYTOCHEMICALS, REDUCING POWER, ANTIOXIDANT ACTIVITY AND IN-VITRO LIPID PEROXIDATION ACTIVITY OF WHEAT GRASS JUICE
Oxidative stress is a condition due to excessive production of free radicals than the ability of the antioxidant system to counteract them. Antioxidants scavenge and suppress the deleterious effects of free radicals. Both exogenous and endogenous sources of antioxidants are important in pathological conditions. Exogenous antioxidants include dietary sources and even include medicinal plants. These...
DEVELOPMENT AND VALIDATIONRP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINETION OF LOPERAMIDE HYDROCHLORIDE AND NORFLOXACIN IN PHARMACEUTICAL FORMULATION
A reverse-phase liquid chromatographic (RP-HPLC) method was developed for the determinations of loperamide hydrochloride and norfloxacin in their marketed formulation and bulk. The separation was carried out using mobile phase of triethylamine and acetonitrile (50:50%) with pH 4.The pH adjusted with orthophosphoric acid. The column used was Capcell pack C18 Column (250mn x 4.6mm, 5mm) and flow rat...
ISOLATION AND DEVELOPMENT OF AN HPLC METHOD FOR THE QUANTIFICATION OF A BIOMARKER IN THE ROOTS OF PAULLINIA PINNATA
An RP-HPLC method to be used to quantitate the amount of a biomarker in the roots of Paullinia pinnata was developed. The root bark was milled and extracted and the dry powder obtained taken through column chromatography (CC). The biomarker was then isolated. The melting point of the biomarker was determined and found to be 117-119 oC. A RP-HPLC method was successfully developed and used to quanti...
A collective assessment of all the morphometric measurements like size, weight, color and shape of the parathyroid gland is important in the determination of its normalcy. After that the histological examination for stromal and intracellular fatty content helps to determine the normalcy of the gland. There have been several studies on morphology of human parathyroid gland, but the grand total of c...
PATTERN & PREDICTORS OF DRUG-DRUG INTERACTIONS AMONG THE PATIENTS ADMITTED IN NEUROLOGY AT A TERTIARY CARE HOSPITAL – A CROSS-SECTIONAL STUDY
Objective: Drug - drug interactions (DDI) is a permanent risk in patients with complex therapeutic regimens. Drugs commonly prescribed in Neurology contribute for most of the potentially hazardous DDI. The present study was undertaken to identify the DDI and its predictors among the patients admitted in Neurology ward. Material and Methods: An analytical cross-sectional study was conducted from Ja...
Background: Pediatrics pose a unique set of risks of medication errors, predominantly because of the need to make dosage calculations, which are individually based on the patient’s weight, age or body surface area (BSA), and their condition. This increases the likelihood of errors, particularly dosing errors. In particular; preventing dosing errors is an important part of ensuring safe and quali...
About 5 extract (hexane, acetone, ethanol, methanol, aqueous extraction) from the flowers of Mangifera indica was extracted. Ethanol extract was characterized by Gas Chromatography-Mass Spectroscopy. Seven constituents from 7 peaks were identified. Icosanedioic acid monomethyl ester, nonadec-16-enyl-benzene, 1, 9 diphenyl nonane, icosane, octadecane, dodecanoic acid butyl ester, tetracosyl- benzen...
EFFECT OF HYDROSOL OF IPOMEA CARNEA LEAVES, FLOWERS AND LANTANA CAMERA LEAVES ON THE GROWTH OF WHEAT, MAIZE AND COTTON PLANT
The Wheat, Maize and Cotton are the major crops in the agriculture field specially in Maharashtra, India. So for better productivity this study aims to prepare steam soluble aroma compounds called hydrosols. Hydrosols of different plant species (Ipomea carnea Leaves and Flowers, Lantana Camera Leaves) were prepared by steam distillation method. The purpose of this study was to determine the effect...
IMPACT OF AN EDUCATIONAL INTERVENTION ON ASTHMA KNOWLEDGE AND METERED-DOSE INHALER TECHNIQUE AMONG NURSING STUDENTS OF GOVERNMENT COLLEGE OF NURSING, BENGALURU
Nurses being one of the important members of the healthcare team, play a significant role in providing care and education. Current effective treatments for asthma are in the form of metered-dose inhalers. An effective control is achieved only when the patient is comfortable to use the metered-dose inhaler device correctly. This study was therefore planned to evaluate their knowledge and to assess ...
A COMPARATIVE STUDY OF EFFECT OF INTRAVENOUS DEXMEDETOMIDINE VS. PLACEBO BEFORE BRACHIAL PLEXUS BLOCK ON PATIENT SATISFACTION AND SUCCESS OF BLOCK
The brachial plexus block(BPB) has gained importance as regional anaesthetic technique for upper limb surgery. The primary aim of our study was to evaluate the addition of intravenous dexmedetomidine before BPB on overall patient satisfaction and sucess with objective of comparing the onset and duration of block, haemodynamic stability and sedation score. A randomized double blind prospective stud...
Background: Malaria is a serious parasitic health problem in India. Plasmodium vivax and falciparum pose the greatest public challenge in endemic areas. P. vivax accounts for more than half of all malaria cases. Accurate and prompt diagnosis is not only important to prevent morbidity, but also helps minimizing drug resistance. Aim: To know the profile of malaria parasite in the patients attending ...
DRUG UTILISATION PATTERN OF PSYCHOTROPIC DRUGS IN PSYCHIATRIC OUTPATIENT DEPARTMENT OF RURAL TERTIARY CARE TEACHING HOSPITAL
Background: Psychiatric disorders are one of the major causes of morbidity. Development of newer drugs like selective serotonin reuptake inhibitors and atypical antipsychotics has altered the treatment paradigms. Objective: To study drug utilization pattern of psychotropic drugs in psychiatric outpatient department. Material and Methods: After ethical approval six month observational, prospective ...
A STUDY TO EVALUATE USAGE OF ANTIMICROBIAL AGENTS AT PRIMARY HEALTH CENTRES AND URBAN HEALTH CENTRES IN AHMEDABAD DISTRICT
Aims and Objectives: To evaluate the use and the impact of interventions on the use of antimicrobial agents (AMAs) at Primary Health Centres (PHCs) and Urban Health Centres (UHCs) in Ahmedabad district. Materials and methods: This was an interventional and prospective study carried out at 5 PHCs and 5 UHCs of ahmedabad district. In pre-intervention phase, 30 adult patients from each centre who wer...
Back ground: Agomelatine is a novel antidepressant which acts through a combination of agonistic actions at MT1 and MT2 subtypes of Melatonergic receptors and antagonistic actions at 5-HT2C subtype of serotonergic receptors. Objective: The study was carried out to evaluate the efficacy and safety of Agomelatine in the treatment of Major depressive disorder. Method: A prospective study was co...
Aim: To rationalize the macroscopial, anatomical and physico- chemical studies on leaves of Ficus benghalensis (Maraceae). Materials & methods: The crude ethanolic extract of leaves of Ficus benghalensis (Maraceae) was using Physico-chemical parameters, and Preliminary photochemical investigation (TLC, HPTLC, & Column Chrmatography). Results and conclusion: An attempt had been made to high...
IMMUNOLOGICAL AND BIOCHEMICAL CHARACTERIZATION OF GLUTATHIONE-S-TRANSFERASE IN PARTHENIUM POLLINOSIS AND ITS CROSS-REACTIVITY WITH BIRCH POLLINOSIS FOR CLINICAL RELEVANCE
Pollinosis is one of the most common allergic diseases in Asia, Central and Northern Europe as well as in North America. Several proteins in parthenium pollen have already been characterized as allergens causing sensitization and the development of allergic symptoms in atopic individuals. Glutathione-S-transferase are a phylogenetically widespread enzyme family mainly involved in cellular detoxifi...
EVALUATION OF MACROSCOPICAL AND MICROSCOPICAL STUDY, PHYTOCHEMICAL ANALYSIS, TLC AND HPTLC FINGERPRINTING OF BAUHINIA PURPUREA LINN. LEAVES
Objective- To rationalize the Macroscopical and Microscopical study, Phytochemical analysis, TLC and HPTLC fingerprinting of Bauhinia purpurea Linn. Leaves. Methods- The crude ethanolic extract of leaves of Bauhinia purpurea Linn. was using the macroscopical characters (size, shape, colour, odour, taste, surface, texture, venation, margin, base, and petiole) powder microscopical study, the powder ...
STUDY OF THE EFFECT OF MELATONIN ON RETENTION OF CONDITIONED AVOIDANCE RESPONSE AND ON ENHANCEMENT OF SEROTONIN MEDIATED BEHAVIOURAL RESPONSES AFTER ELECTROCONVULSIVE SHOCK (ECS) ADMINISTRATION IN RATS
Objectives: To obtain the data regarding the effects of melatonin on retention of conditioned avoidance response (CAR) and on enhancement of serotonin mediated behavioural responses after electroconvulsive shock (ECS) administration in rats. Methods: Forty rats after training for conditioned avoidance response by using Cook’s pole climbing apparatus were divided in four groups with ten rats in e...
The aim of the present study is to evaluate the ameliorative effect of curcumin against profenofos induced oxidative damage of renal tissue in mice. Animals were divided into four different groups namely Group-I (control mice; NC), Group-II (NC gavaged 100µl ethanol for 30 days; EC), Group-III (NC gavaged 25mg/kg b.w profenofos for alternate 30 days; PC) and Group-IV (PC treated with 120mg/kg b.w...