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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 3 (2012) - Issue 5, May

Review Articles

 
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1.

ASPECTS OF THE AMLODIPINE PLEIOTROPY IN BIOCHEMISTRY, PHARMACOLOGY AND CLINICS

Amlodipine is the third generation calcium antagonist, 1,4-dihydropyridine derivative with the prolonged duration of the antihypertensive action, especially blocking L-type Ca2+ ion channels. It promotes beneficial therapeutic effect by coronary and other blood vessel diseases and thus delays development of the atherosclerosis. It has several known trade names, the most mentioned is Norvasc. Amlod...

Rasma Vitolina, Aivars Krauze, Gunars Duburs and Astrida Velena*

Latvian Institute of Organic Synthesis, Laboratory of membrane active compunds and β-diketones, Aizkraukles str. 21, Riga, Latvia, LV-1006

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1215-32

1215-1232

2466

652

2.

CORIANDRUM SATIVUM- REVIEW OF ADVANCES IN PHYTOPHARMACOLOGY

Coriandrum Sativum family Umbelliferae is highly reputed ayurvedic medicinal tree commonly known as the Dhanya. It is a glabrous, aromatic, herbaceous annual plant, small sized tree growing throughout India, Italy, Netherlands, Central and Eastern Europe, China and Bangladesh. Essential oil, flavonoids, fatty acids, and sterols have been isolated from different parts of C. sativum. The different p...

Abidhusen H. Momin*, Sawapnil S. Acharya and Amit V. Gajjar

Department of Pharmacology, K. B. Institute of Pharmaceutical Education and Research, Gh- 6, Sector- 23, Ghandhinagar- 382023, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1233-39

1233-1239

4118

2678

3.

PUNICA GRANATUM: A REVIEW ON PHARMACOLOGICAL AND THERAPEUTIC PROPERTIES

A wide range of medicinal plant parts is used as raw drugs and they possess varied medicinal properties. The different parts used as raw drugs include root, stem, flower, fruit, twigs exudates and modified plant organs. The Punica granatum is a native shrub of occidental Asia and Mediterranean Europe that has a rich history of traditional use in medicine. For centuries, the barks, leaves, flowers,...

Neelam Arun and D. P. Singh

Department of Environmental Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow-226 005, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1240-45

1240-1245

3738

1358

4.

ASTAXANTHIN: A POTENTIAL CAROTENOID

Astaxanthin, a member of the carotenoid family, is a dark-red pigment which is the main carotenoid found in the marine world of algae and aquatic animals. Astaxanthin, is present in many types of seafood, including salmon, trout, red sea bream, shrimp and lobster, as well as in birds such as flamingo and quail. Synthetic Astaxanthin dominates the world market but recent interest in natural sources...

Jyotika Dhankhar*, Sumita S. Kadian and Asha Sharma

Department of Food Technology 1, M. D. U., Rohtak, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1246-59

1246-1259

3870

1099

5.

MECHANICAL, CHEMICAL AND HERBAL ASPECTS OF PERIODONTITIS: A REVIEW

Periodontitis is a common and widespread disease, which occurs due to the pathogenic bacterial infections (like Porphyromonas gingivalis, Bacteroides spp., E. coli, Staphylococcus aureus, S. mutans etc.) established within the gingival sulcus. This condition, when not arrested, will cause formation of periodontal pocket. In order to eliminate or control the disease and arrest further periodontal t...

Sagar Bansal*, Shruti Rastogi and Meenakshi Bajpai

College of Pharmaceutical Sciences, Raj Kumar Goel Institute of Technology, 5 km Stone, Delhi-Meerut Road, Ghaziabad, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1260-67

1260-1267

1784

602

6.

MEDICINAL PLANTS WITH POTENT ANTIOXIDANT CONSTITUENTS

Oxygen free radicals induce damage due to peroxidation to bio-membranes and also to DNA, which leads to tissue damage, thus cause occurrence of a number of diseases and biochemical disorders. Antioxidants neutralize the effect of free radicals through different ways and may prevent the body from various diseases. Antioxidants may play vital role in the metabolic disorders. India stands with highes...

G. Murugananthan* and Sathya Chethan Pabbithi

Department of Pharmacognosy, PES College of Pharmacy, Bangalore-560050, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1268-73

1268-1273

1763

632

7.

COLON TARGETED DRUG DELIVERY: CURRENT AND NOVEL PERSPECTIVES

In general, we know that small intestine is mostly the site for drug absorption but in some cases the drug needs to be targeted to some other sites for absorption due to various factors like any disease condition, degradation related situations, for sustained release of drugs etc. Colon targeted drug delivery is a relatively new concept for the absorption of drugs as it offers near neutral pH. Als...

Surender Verma , Vipin Kumar*, D. N. Mishra and S. K. Singh

Associate Professor, Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1274-84

1274-1284

2978

1226

8.

MADHUCA INDICA: A REVIEW OF ITS MEDICINAL PROPERTY

Medicines obtained from plant source are known as an herbal medicine, and the herbal medicine are one which make human healthy without causing any of harmful effect. Madhuca Indica is a plant of Indian origin having tremendous therapeutic potential but is not fully utilized. It is hidden from the eyes of the researchers and other botanist. Madhuca Indica has several pharmacological activity, and p...

Pushpendra K. Patel*, Narendra K. Prajapati and B.K. Dubey

T.I.T. College of Pharmacy, Department of Pharmacology, Anand Nagar, Bhopal- 462 021, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1285-93

1285-1293

8708

2818

Research Articles

 
Title
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Cited
9.

EFFECT OF CHANDANASAV, AN AYURVEDIC FORMULATION, ON MICE WHOLE SPLENOCYTES FOR THE PRODUCTION OF POLYCLONAL IgM AND PROLIFERATION OF CELLS: A PRELIMINARY STUDY

In recent days, it has been given great emphasis on the scientific evaluation of traditional or complementary and alternative medicines in order to justify the traditional use, safety, efficacy, quality, and to know its therapeutic values that have not yet explored. Chandanasav, an ancient Ayurved formulation, is commonly used for the treatment of malnutrition, presence of semen in the urine, and ...

Md. Moklesur Rahman Sarker*, MSK Choudhuri and Ming Zhong

Assistant Professor, Department of Pharmacy, Faculty of Science and Information Technology, Daffodil International University, 102 Sukrabad, Dhaka-1207, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1294-99

1294-1299

1641

382

10.

ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES OF GOUANIA LONGIPETALA HEMSL

Background: Gouania longipetala Hemsl. (Rhamnaceae), has ethnomedicinal use in the treatment of wounds, gonorrhoea, abdominal pain, lumbago, ophthalmia, conjunctivitis, and rickets. However, no scientific investigation of these effects has been established. Our aim was to verify the antibacterial, antioxidant and anti-inflammatory effects of the stem of Gouania longipetala.  Methods: The antibact...

Edmund Ekuadzi*, Rita A. Dickson and Theophilus C. Fleischer

Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, KNUST, Kumasi, Ghana

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1300-05

1300-1305

1627

402

11.

ANTIDIARRHOEAL ACTIVITY, NITRIC OXIDE SCAVENGING AND TOTAL TANNIN CONTENT FROM THE BARK OF CERIOPS DECANDRA (GRIFF.) DING HOU

The present study was designed to investigate the antidiarrhoeal, nitric oxide scavenging and total tannin content from the ethanolic extract of the bark of Ceriops decandra (Griff.) Ding Hou (Family: Rhizophoraceae). The ethanol extract at graded doses (200 & 400 mg/kg body weight) was investigated for antidiarrhoeal activity in term of reduction in the rate of defecation and consistency of f...

Md. Hemayet Hossain*, Md. Musfizur Hassan , Ismet Ara Jahan , Ishrat Nimmi , and Amirul Islam

Senior Scientific Officer, Chemical Research Division, BCSIR Laboratories, Dhaka, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka-1205, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1306-11

1306-1311

1332

522

12.

ANATOMICAL CHARACTERIZATION AND MICROCHEMISTRY OF VISMIA GUIANENSIS (AUBL.) CHOISY (CLUSIACEAE) BLADE LEAF

Vismia guianensis (Aubl.) Choisy is a tree that belongs to the secondary vegetation in rainforests. This study aimed to perform anatomy analysis by light microscopy; scanning and microchemistry of the leaves of V. guianensis. Tri stratified upper epidermis with intense cutinization and unistratified inferior epidermis was observed. The stomata found are paracytic and the trichomes arranged in rose...

Sarah Regina Pereira Camelo , Russany Silva Costa , Janaina Gell de Pontes Vieira , Roseane Maria Ribeiro-Costa , Wagner Luiz Ramos Barbosa , Flavio Vasconcelos , Jose Otavio Carrera Silva Junior*

Adj. Prof., Laboratory of Pharmaceutical Technology, School of Pharmacy, Institute of Health Sciences, Federal University of Para, University City “Jose da Silveira Netto”, CEP 66075-110, Belem, Para, Brazil

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1312-17

1312-1317

1387

422

13.

ANTI-DIABETIC ACTIVITY OF ROOTS OF QUERCUS INFECTORIA OLIVIER IN ALLOXAN INDUCED DIABETIC RATS

The methanolic extract of roots of Quercus infectoria Olivier at a dose of 250 mg/kg and 500 mg/kg body weight respectively was tested for anti-diabetic activity in Alloxan-induced hyperglycaemic rats. The blood glucose levels were measured at 0, 2h, 4h and 6h after the treatment. The methanolic extract reduced the blood glucose Alloxan- induced diabetic rats from 285.52 to 206.57mg/dl, 6h after o...

R. Saini * and S.M. Patil

Department of Pharmacy, Shree Dev Bhoomi Institute of Education, Science and Technology, Dehradun, Uttarakand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1318-21

1318-1321

1397

596

14.

PRELIMINARY PHYTOCHEMICAL, ANTI-BACTERIAL, ANALGESIC, ANTI-DIARRHOEAL AND CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACT OF POLYALTHIA SUBEROSA LEAVES

The MeOH extract of leaves of Polyalthia suberosa Roxb. (Annonaceae) was screened for its antibacterial, analgesic, Antidiarrhoeal and cytotoxic activities. The extract showed moderate anti-bacterial activity against Vibrio cholerae, Sheigella sonnei, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus saprophyticus. It also produced significant (P<0.01) writhing inhibition in a...

Sm. Faysal Bellah , Firoj Ahmed , A.A. Rahman , I.Z. Shahid and S.M. Moazzem Hossen*

Lecturer, Department of Pharmacy, University of Science & Technology Chittagong, (USTC), Foy’s Lake, Kulshi, Chittagong 4202, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1322-26

1322-1326

1297

677

15.

PREPARATION AND PROPERTIES OF MACROCYCLIC LIGAND AND ITS COMPLEXES DERIVED FROM TRIMETHOPRIM AND DIETHYL PHTHALATE

Macrocyclic complexes of  MnII, CoII, NiII and CuII   using a macrocyclic ligand derived by the condensation of Trimethoprim and diethyl phthalate have been prepared and characterized by electronic, IR and NMR spectral studies as well as magnetic moment and conductivity. On the basis of spectral studies, an octahedral geometry has been proposed for all the complexes....

M. Amaladasan and P. Victor Arockiadoss*

Postgraduate and Research Department of Chemistry, St. Joseph’s college (Autonomous), Tiruchirappalli-620002, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1327-30

1327-1330

1280

551

16.

QUANTITATIVE AAS STIMATION OF HEAVY METALS AND TRACE ELEMENTS IN MARKETED AYURVEDIC CHURNA PREPARATIONS IN INDIA

Churna preparations are an important and widely used form of Ayurvedic herbal formulations in India. These are prepared by mixing powdered form of single or mixture of several crude drugs meant to be dispensed as such. Since the quality of raw material plays an important role in the overall quality of a herbal formulation due to common practice of collecting and processing medicinal plants from di...

Munish Garg* and Jaspreet Singh

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1331-36

1331-1336

1994

853

17.

LUPEOL PROTECTS ABNORMALITIES IN CELL SURFACE MOITIES DURING 7, 12-DIMETHYLBENZ[A]ANTHRACENE INDUCED HAMSTER BUCCAL POUCH CARCINOGENESIS

Lupeol, a pentacyclic triterpene, possesses diverse pharmacological and biochemical activities including anticancer and antioxidant effects. Abnormalities in the status of glycoconjugates and lipids in the cell results in malignant transformation. The aim of the present study was to investigate the protective effect of lupeol on cell surface glycoconjugates and lipids abnormalities during 7,12-dim...

D. Palanimuthu and S. Manoharan*

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar- 608 002, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1337-42

1337-1342

1022

389

18.

BIOREMEDIAL IMPACT OF WITHANIA SOMNIFERA ON ENDOSULFAN EXPOSED SPERMATOZOA OF MICE

Background/Aim: Endosulfan is a pesticide of organochlorine group uses by 55 % of farmers in Bihar. Present study aims to illustrate effect of Endosulfan on biochemical, hormonal and sub cellular anomalies of spermatozoa of mice and their restoration through root extract of Withania somnifera. Materials and Methods: Experimental mice were administered with endosulfan for eight weeks followed by...

Ranjit Kumar*, Md Ali, J.K.Singh, A.Nath, and Arun Kumar

Mahavir Cancer Institute & Research Centre, Phulwarisharif, Patna, Bihar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1343-47

1343-1347

1183

389

19.

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF METOPROLOL SUCCINATE AND TELMISARTAN IN COMBINED PHARMACEUTICAL FORMULATION

Four simple, rapid, precise, economical and accurate spectrophotometric methods have been developed for simultaneous analysis of Metoprolol succinate and Telmisartan in their combined dosage form. Method 1, First derivative simultaneous equation method (Vierodt’s method). It employs formation and solving of simultaneous equation using two wavelengths 230.2 nm (λmax of Metoprolol succinate) and ...

Mayur Modi*, Rikin Shah and R.C. Mashru

Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System, Pharmacy Department, G. H. Patel Building, Donor’s Plaza, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara – 390 002, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1348-54

1348-1354

1961

557

20.

ANTIMICROBIAL ACTIVITY OF MENTHA ARVENSIS AGAINST CLINICAL ISOLATES OF HUMAN CARIOGENIC PATHOGENS- AN IN-VITRO STUDY

Patients with chronic dental infection are usually treated with antibiotics. However, the value of antibiotics was decreasing because increased resistance in bacteria. The objective of this study is to evaluate the efficacy of herbal crude extract of Mentha arvensis in human Cariogenic pathogens. In this study we obtained crud extract of Mentha arvensis  in different solvent 50% and 10% methanol,...

Deepak Dwivedi, Gaurav Khandelwal , Rakesh Kumar Patidar and Vinod Singh*

Associate Professor & Head, Department of Microbiology, Barkatullah University, Hoshangabad Road, Bhopal, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1355-60

1355-1360

2295

870

21.

STUDIES ON VIBURNUM NERVOSUM HOOK CHEMISTRY AND SPECTROSCOPY OF BERGENIN AND ITS DERIVATIVES

Bergenin is reported to occur in Viburnum nervosum (Capprifoliaceae). This is the first report of its occurrence in genus Viburnum. Derivative of Bergenin viz Bergenin diethyl ether, its penta acetate and diethyl ether triacetate have been prepared. Their method of preparation and characterization by spectroscopy is reported for the first time....

Brijesh K. Tiwari* and R.L. Khosa

Department of Pharmacy, Bharat Institute of Technology, Meerut- 250 103, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1361-63

1361-1363

1173

530

22.

EFFECT OF REGULAR GARLIC INGESTION ON BODY WEIGHT AND BLOOD GLUCOSE: A CASE STUDY IN MICE

Garlic a perennial erect plant is known to have sulphur-containing compounds that act on the hypothalamus increasing the sensitivity of the hypothalamus to leptin which alters the set point at which satiety is reached causing an organism to eat less. Nine mice (six of which were obese) were used in this study and grouped into three. Groups A and B were made of 3 obese mice each whereas group C con...

F.T. Djankpa, A. Osonuga*, J. Ekpale, C.E. Quaye, P. Otoo, O.A. Osonuga and S.K. Amoah

School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1364-66

1364-1366

1879

392

23.

ASSESSMENT OF PHYSICO-CHEMICAL STATUS OF GROUND WATER SAMPLES OF PARBHANI DISTRICT (M.S., INDIA)

Ground water is the most preferred water source in recent day. Once believed to be safe from pollution as it is available many strata below the surface, is now provided to be prone to pollution by many researchers across the world. The contamination of ground water may be due to improper disposal of domestic and industrial west water. A study was carried out to assess the ground water quality of P...

D.A. Dhale* and G.L. Pachkore

Assistant Professor, PG-Department of Botany, S.S.V.P.S.Sansthas, L.K. Dr. P.R. Ghogrey Science College, Dhule-424005, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1367-70

1367-1370

1298

379

24.

DRUG UTILIZATION PATTERN AND POTENTIAL TERATOGENESITY RISK AMONG PREGNANT WOMEN; THE CASE OF AYDER REFERRAL HOSPITAL, TIGRAY – ETHIOPIA

It is important to treat the mother whenever needed while protecting the unborn from any side effects to the greatest possible extent. Objective of this study is to assess the utilization pattern and the teratogenesity risk of the drugs prescribed among pregnant women in Ayder referral hospital, Mekelle, Ethiopia. Retrospective study was employed to assess drug utilization pattern and teratogenesi...

Tesfalem Lukas Gebreegziabher , Derbew Fikadu Berhe*, Girma Belachew Gutema and Balkachew Nigatu Kabtyimer

Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1371-78

1371-1378

1860

775

25.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CANDESARTAN BY DERIVATIVE SPECTROSCOPY (FIRST ORDER AND SECOND ORDER)

Candesartan cilexetil, a prodrug is a racemic mixture containing one chiral center at the cyclohexyloxy-carbonyloxy- ethyl ester group. It is soluble in dimethyl formamide, acetone, methanol, 0.1 N sodium hydroxide solution and insoluble in water. Objective of the present study is to develop a simple, sensitive, accurate, precise and rapid derivative spectrophotometric method for the estimation of...

Gunjan Kalyani*, Vishal S. Deshmukh, Yogesh Vaishanv and Pranita Kashyap

Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1379-84

1379-1384

1516

494

26.

IN VITRO CYTOTOXICITY OF MADHUCA INDICA AGAINST DIFFERENT HUMAN CANCER CELL LINES

Cancer is a public health problem all over the world. Large number of plants and their isolated constituents has been shown to potential anticancer activity. Ethanolic whole plant extract of Madhuca indica showed in vitro cytotoxicity against different human cancer cell lines such as lung, neuroblastima, and colon. There was no growth of inhibition recorded against liver cancer cell line. Sulforho...

Asima Shaban , Satish K. Verma*, Rajesh Nautiyal Santosh Kumar Singh , Reena Purohit and Madhvi Lata Chimata

Lecturer, Department of Zoology, K.L.P.G College, Naini, Allahabad, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1385-87

1385-1387

1451

514

27.

CNS DEPRESSANT ACTIVITY OF ETHANOL EXTRACT OF DERRIS TRIFOLIATA

In the present study, we investigated neurobehavioral activity of ethanol extract of the aerial parts of Derris trifoliata (Lour.) in mice as a part of a psychopharmacological screening of this plant. The effects of the plant extract on CNS were studied by using potentiation of phenobarbitone-induced sleeping time and exploratory behavior in mice. The crude extract (500 mg/kg body weight) signific...

Saifullah Al Mamoon , Farhad Hossen and Md. Golam Azam*

Assistant Professor, Department of Pharmacy, Northern University Bangladesh, 93, Kazi Nazrul Islam Avenue, Kawran Bazar, Dhaka-1215, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1388-92

1388-1392

1155

503

28.

FORMULATION AND EVALUATION OF CURCUMIN LOADED MAGNETIC NANOPARTICLES FOR CANCER THERAPY

The conventional chemotherapeutic agents in oncology drug discovery still exhibit poor specificity in reaching tumor site and often restricted by dose-limiting toxicity. The combination of developing drug formulation by utilizing both controlled release technology and drug targeting technology may provide a more efficient and less harmful solution to conquer the limitations found in conventional c...

T. Silambarasi, S. Latha*, M. Thambidurai and P. Selvamani

Department of Pharmaceutical Technology, Anna University of Technology, Tiruchirappalli - 620024, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1393-00

1393-1400

1990

603

29.

CARDIO-VASCULAR ACTIVITY OF GYNURA PROCUMBENS MERR. LEAF EXTRACTS

Gynura procumbens has been known to be used as traditional medicine for treatment of kidney disease, rashes, fever and for hypertension. We report here the cardiovascular effects of the different ethanol (95%, 75%, 50%, 25% v/v) and water extracts using in vitro studies. Gynura procumbens leaves extract was prepared by maceration process. The cardiac effects (chronotropic and ionotropic) of each e...

Navneet Kaur*, Ammar Ihsan Awadh , Rabyah B. Ali , Amirin Sadikun , Munavvar Zubaid Bin Abdul Sattar and Mohd Zaini Bin Asmawi

(Ph. D. Student), Department of Physiology and Pharmacology, School of Pharmaceutical Sciences, USM, Minden, 11800 Penang, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1401-05

1401-1405

1899

577

30.

AN IN-VIVO EVALUATION OF ANTIPLASMODIAL ACTIVITY OF AQUEOUS AND ETHANOLIC LEAF EXTRACTS OF AZADIRACHTA INDICA IN PLASMODIUM BERGHEI INFECTED BALB/c MICE

Malaria remains one of the most prevalent infections in the tropical regions of the world. The increased resistance of the parasite to many available antimalarials backs the need to develop novel antimalarial drugs with effective mode of action. Several plants with antiplasmodial properties have been proved as sources for novel antiplasmodial compounds. Azadirachta indica has widely been reported ...

L.A. Oseni* and G.M. Akwetey

Department of Applied Chemistry & Biochemistry, University for Development Studies, Navrongo Campus, P.O. Box 24, Navrongo, U/E, Ghana

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1406-10

1406-1410

1249

329

31.

AN IN-VITRO STUDY FOR MUCOADHESION AND CONTROL RELEASE PROPERTIES OF GUAR GUM AND CHITOSAN IN ITRACONAZOLE MUCOADHESIVE TABLETS

This study describes the effect of Guar gum and chitosan on formulation of mucoadhesive drug delivery system of itraconazole. Mucoadhesive strength, Drug content, Hardness, Friability, Weight variation, Moisture content and accelerated stability studies were performed to study the effect of polymers on prepared mucoadhesive tablets. Results of the present study clarified the potential of guar gum ...

A. A. Shaikh*, Y. D. Pawar and S. T. Kumbhar

Department of Pharmaceutics, Indira College of Pharmacy, “Niramaya” 89/2-A, Tathawade, Pune-411033, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1411-14

1411-1414

1301

462

32.

CHEMICALLY FABRICATED SILVER NANOPARTICLES ENHANCES THE ACTIVITY OF ANTIBIOTICS AGAINST SELECTED HUMAN BACTERIAL PATHOGENS

Due to the outbreak of infectious diseases caused by different pathogenic bacteria and the development of antibiotic resistance, the pharmaceutical companies and the researchers are now searching for new unconventional antibacterial agents.  Nanotechnology represents a modern and innovative approach to develop new formulations based on metallic nanoparticles with antimicrobial properties. The pot...

S. Thangapandiyan and P. Prema*

Post Graduate and Research Department of Zoology, V.H.N.S.N. College, Virudhunagar- 626 001, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1415-22

1415-1422

1321

481

33.

ANTIHYPERLIPIDEMIC EFFECT OF TINOSPORA CORDIFOLIA EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS

The present study was aimed to evaluate the antihyperlipidemic effect of aqueous extract of stem of Tinospora cordifolia in streptozotocin induced diabetic and diet induced hyperlipidemic rats. Diabetes mellitus was induced in male albino Wistar rats by intraperitoneal injection of streptozotocin (45 mg/kg b.w.). Hyperlipidemia was induced in diabetic rats by feeding 0.5% cholesterol and 0.1% chol...

K. Vetrivadivelan *, K.V. Venkateswaran , S. Selvasubramanian and P.S.L. Sesh

Research Scientist, No. 6, Dhamodaran Street, O.V. Alagesan Nagar, Ambattur, Chennai – 600 053, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1423-29

1423-1429

2012

518

34.

EXTRACTION AND PHYTOCHEMICAL SCREENING OF MIKANIA SCANDENS LINN. AND EVALUATION OF ITS METHANOLIC EXTRACT FOR ANALGESIC ACTIVITY

Mikania scandens is a rapidly growing herbaceous to semi-woody, perennial vine. It grows quickly over other plants such as young trees, smothering them; it can climb trees up to 25 m tall. Although not as serious a weed as M. chordate, in Southeast Asia it has become a hard to eradicate weed of tea, rubber, and other plantation crops. It also reduces the carrying capacity of pasture. The achenes a...

Raja Chakraverty and Sudeshna Saha

Gupta College of Technological Sciences, Ashram More, Asansol-713 301, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1430-32

1430-1432

1354

409

35.

FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASED GLIBENCLAMIDE MICROSPHERES

In the present investigation, an attempt has been made to prepare sustained release microspheres of Glibenclamide by using Eudragit RS 100 as rate retardant polymer. Microspheres were successfully prepared by non-aqueous emulsion solvent evaporation method. Magnesium stearate was used as hydrophobic dispersant and droplets stabilizer. The yields were varies from 90-97% and encapsulation efficacy i...

S.K. Dash*, A.S. Khan, S. R. Das, A. Padhan, D. Rout and B.C. Behera

Department of Pharmaceutics, The Pharmaceutical College, Barpali, Bargarh, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1433-43

1433-1443

1741

728

36.

ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACT OF BARK OF BAUHINIA PURPUREA

The present investigation was carried out to study the antidiabetic effect of the methanolic extract of bark of Bauhinia purpurea in Streptozotocin induced diabetic model. The antidiabetic activitywas evaluated in normal & Streptozotocin induced diabetic rats. Decreased blood glucose level of the test animals showed that the extract exhibited significant antidiabetic activity when compared to ...

S. Pahwa*, R. Mazumder and S. Bhattacharya

A-227, Sarita Vihar, New Delhi, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1444-47

1444-1447

1096

506

37.

ISOLATION AND SCREENING OF HEAVY METAL ABSORBING BACTERIA FROM THE INDUSTRY EFFLUENT SITES OF THE RIVER NAGAVALI

The present study was designed to evaluate the heavy metal absorbing potential of bacteria isolated from industry effluent sites of river Nagavali, Srikakulam Andhra Pradesh. From the effluent waste water three bacteria were isolated and confirmed as Staphylococcus aureus and Staphylococcus epidermidis and Staphylococcus saprophyticus after performing various biochemical tests. The heavy metal tol...

Satpal Singh Bisht*, B. Praveen, M. Rukmini and Harman Dhillon

Department of Biotechnology, Roland Institute of Pharmaceutical Sciences, Berhampur-760010, Orissa, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1448-51

1448-1451

1462

412

38.

SPASMOLYTIC ACTIVITY OF CASUARINA EQUISETIFOLIA BARK EXTRACT

Casuarina equisetifolia (Casuarinaceae) is considered a medicinal plant and is traditionally used for the treatment of diarrhoea. Preliminary phytochemical screening of methanolic extract of the aerial bark revealed the presence of carbohydrates, alkaloids, proteins, glycosides, saponins, flavonoids and tannins. The extract reduced contractions in isolated ileum induced by spasmogens like ACh, His...

D. V. Kishore and Rumana Rahman*

Department of Pharmacology, Shadan College of Pharmacy, Peerancheru, RR Distt, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1452-56

1452-1456

1498

585

39.

IN VITRO EVALUATION OF ANTIBACTERIAL POTENTIAL OF ANNONA SQUAMOSA L. AGAINST PATHOGENIC BACTERIA

Three different solvent extracts of seeds of Annona squamosa L. were studied for its antibacterial activity. Agar cup method was selected to test antibacterial activity using two Gram-positive (Bacillus subtilis, Staphylococcus aureus) and three Gram-negative (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacteria. The screeningresults showed that highest inhibition was obser...

P. S. Aher*, Y.S. Shinde and P. P.Chavan

Department of Microbiology, K.K. Wagh College of Agricultural Biotechnology, Sarswati Nagar, Panchavati, Nashik- 422 003, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1457-60

1457-1460

1615

667

40.

CHARACTERISATION OF BIOACTIVE COMPOUNDS IN COSTUS SPECIOSUS (KOEN). BY REVERSE PHASE HPLC

Costus speciosus belongs to the family Zingiberaceae and contains lots of medicinal properties. The aim of this study was to screen, characterise and quantify the selected biomolecules viz. phenolics, proteins in C. speciosus. Ethanol extract possessed high amount of phenolics than the acetone and aqueous extract. Aqueous extract has least amount of phenolics compared to ethanol and acetone extrac...

J. Karthikeyan*, V. Reka and Raja V. Giftson

Scientist cum Assistant Professor, Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1461-65

1461-1465

1543

486

41.

FORMULATION AND EVALUATION OF SUSTAINED RELEASE AMBROXOL HYDROCHLORIDE MICROSPHERES

Polymethyl mehtacrylates polymers such as Eudragit RL100 have been used in preparation of matrix type oral sustained release, coating and in microencapsulation of drug. Embedding of drug within an insoluble matrix is convenient way of controlling the drug release.The prepared microspheres by emulsion solvent evaporation technique was simple and reproducible, possessed good sphericity, smooth surfa...

Rupinder Dhot, Karambir Singh , Shaheeda and Shaik Shabbeer*

Department of Pharmaceutics, Swami Ramananda Tirtha Institute of Pharmaceutical Sciences, Ramananda Nagar, Nalgonda-508004, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1466-74

1466-1474

1652

553

42.

CARDIOPROTECTIVE EFFECT OF MORUS ALBA L. LEAVES IN ISOPRENALINE INDUCED RATS

The study was designed to evaluate the cardioprotective effect of methanolic extract of Morus alba L. leaves against isoprenaline- induced myocardial infarction and was investigated by an in vivo method in rats. Male Wistar albino rats were divided into four groups (n=6). Group I rats served as normal control. Group II rats served as isoprenaline induced toxic control (110 mg/kg body weight) which...

S. Madhumitha and A. Indhuleka*

Assistant Professor, PG & Research Department of Biotechnology, Kongunadu Arts & Science College, Coimbatore-641029, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1475-80

1475-1480

1422

393

43.

LIQUISOLID TECHNIQUE FOR ENHANCEMENT OF DISSOLUTION PROPERTIES OF FENOFIBRATE

The in vitro dissolution property of slightly water soluble Fenofibrate (FN) was improved by exploring the potential of Liquisolid system (LS). The in vitro release pattern of LS compacts and directly compressed tablets were studied using USP-II apparatus. Different LS compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce...

P.M. Sabale*, N.D. Grampurohit , D.D.Gaikawad , M.V.Gadhave , G.M. Shingade , G. Shaik

Department of Pharmaceutics, Vishal Institute of Pharmaceutical Education & Research, Ale, Pune – 412411, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1481-86

1481-1486

1405

423

44.

INHIBITION OF ACETYLCHOLINESTERASE IN ALZHEIMER’S DISEASE- AN IN SILICO APPROACH

Alzheimer's disease (AD) is a progressive degenerative disease of the brain marked by gradual and irreversible declines in cognitive functions. Acetylcholinesterase plays a biological role in the termination of nerve impulse transmissions at cholinergic synapses by rapid hydrolysis of acetylcholine. The deficit levels of acetylcholine lead to poor nerve impulse transmission. Thus the cholinesteras...

S. Aishwarya

Department of Biotechnology and Bioinformatics, Bishop Heber College, Tiruchirappalli-625 017, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1487-94

1487-1494

1628

629

45.

DEVELOPMENT OF NEW ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF RACECADOTRIL AS AN ACTIVE PHARMACEUTICAL INGREDIEN BY UV SPECTROPHOTOMETER

A simple and sensitive spectroscopic method was developed for the estimation of Racecadotril in pharmaceutical dosage forms. This method is based on Racecadotril, showing absorbance at 231 nm in methanol. This method obeys Beers law in the concentration range of 8 to100 μg mL-1 respectively. The proposed method is precise, accurate and reproducible and can be extended to the analysis of Racecadot...

Pintoo Tank*, Aarti Zanwar, A.K. Seth and Sharad Kumar

Department of Pharmacy, Sumandeep Vidyapeeth, Vadodara- 391 760, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1495-97

1495-1497

1359

638

46.

EVALUATION OF ANTI ULCER ACTIVITY OF AEGLE MARMELOS LEAVES EXTRACT

The objective of present study is to evaluate the anti ulcer activity of methanolic extract of leaves of Aegle marmelos. The cause of ulceration in patients is mainly due to hypersecretion of gastric juice and pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. The anti-ulcer activity of methanolic extract of Aegle marmelos ...

Ashoka M. Shenoy*, Rajnikant Singh, Rajan Moses Samuel, R. Yedle and A.R. Shabraya

Department of Pharmacology, Srinivas College of Pharmacy, Mangalore-574 143, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1498-01

1498-1501

1621

462

47.

SCREENING OF PLANTS FOR ANTI DERMATOPHYTE ACTIVITY

Mycotic infections of skin are caused by dermatophytes. Screening of plants for anti dermatophyte activity was carried out based on the literature search done. Native plants of Maharashtra (India) were screened for anti dermatophyte activity. Various plant parts from different regions were collected and then extracted with three different solvents viz. alcohol, hydro-alcohol and aqueous. The obtai...

V.S. Chauhan, A. Suthar, V. Naik and K. Salkar*

Piramal HealthCare Limited, Nirlon Complex, 1A, 1B, 1C, Off Western Express Highway, Goregaon (east), Mumbai-400063, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1502-06

1502-1506

1444

469

48.

PHYTOCHEMICAL STUDIES ON CAPSICUM FRUTESCENS

Two chemical compounds have been isolated and their structures were elucidated by spectroscopic studies including VLC, TLC and NMR. The isolated compounds are Ortho-hydroxy-N- benzyl- 16- Methyl- 11, 14- diene-octadecamide (1) and 9, 12-diene-octadecanoic acid (2)....

Mohammad Golam Dastagir , Mohammad Musarraf Husaain*, A.H.M. Masum Billah , Md. Ismail , Abdul Quader

Department of Pharmacy, Jagannath University, Dhaka-1100, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1507-10

1507-1510

2315

872

49.

KNOWLEDGE OF ADVERSE DRUG REACTIONS AND PHARMACOVIGILANCE ACTIVITY AMONG THE UNDERGRADUATE MEDICAL STUDENTS OF GUJARAT

Aims & Objectives: The objective of this study was to analyze the baseline knowledge of awareness regarding the ADRs and Pharmacovigilance activity in the undergraduate medical students of different Medical Colleges in Gujarat, India. Correspondence to Author: Dr. Mukeshkumar B. Vora {M.B.B.S, M.D (Pharmacology)} Assistant Professor in Pharmacology, Department of Pharmacology Gove...

Mukeshkumar B. Vora*,Narendra P. Paliwal , Vikas G. Doshi, Manish J. Barvaliya and C.B. Tripathi Narendra P. Paliwal 1, Vikas G. Doshi 2, Manish J. Barvaliya 1 and C.B. Tripathi 1

Assistant Professor in Pharmacology, Department of Pharmacology Government Medical College, Bhavnagar-364001, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1511-15

1511-1515

1399

562

51.

ISOLATION AND CHARACTERIZATION OF POLYPHENOLIC COMPOUND QUERCITIN FROM PHYLLANTHUS EMBLICA

The curative parts of medicinal plants are not simply its woody stem or its leaves but the number of chemical compounds (phytoconstituents) it produces and uses for its own growth like flavonoids, alkaloids, gum, mucilage, protein, carbohydrate etc. The genus Phyllanthus is widely used in medicine but still lot of work left to explore this genus. So the species, Phyllanthus emblica which is widely...

Prabodh Shukla*, Padmini Shukla and B. Gopalkrishna

EWS-915, Avas Vikas Colony-3, Kalyanpur Panki Road, Kanpur- 208017, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1520-22

1520-1522

1649

567

52.

ANTIMICROBIAL ACTIVITIES AND PRELIMINARY PHYTOCHEMICAL SCREENING ON THE CRUDE EXTRACTS OF THE LEAVES OF CINERARIA ABYSSINICA SCH. BIP. EXA. RICH

In Ethiopian traditional medicine, the aqueous decoction of the leaves of Cineraria abyssinica Sch. Bip. exA. Rich (Asteraceae) is used for treatments of various ailments including diarrhea, however, to date, there appear to have been no reports on the phytochemistry and the antimicrobial activity of the plant. The main aim of this study was, therefore, to carry out preliminary phytochemical scree...

Biruk Sintayehu*, Kaleab Asres and Avijit Mazumder

Lecturer, B. Pharm, M. Sc. (Pharmacognosist), Pharmacognosy Course and Research Unit, Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1523-27

1523-1527

2178

489

53.

IN VITRO ANTIOXIDANT, TOTAL PHENOLIC CONTENT AND BRINE SHRIMP LETHALITY STUDIES OF SYNEDRELLA NODIFLORA

The antioxidant activity of methanol extract of whole plant of Synedrella nodiflora  as well as its petroleum ether, carbon tetrachloride, dichloro-methane and aqueous soluble partitionates were evaluated by DPPH of (1, 1-diphenyl-2-picrylhydrazyl) and phosphomolybdenum total antioxidant assay and compared with standard antioxidants butylated hydroxytoluene (BHT) and ascorbic acid (ASA).  The to...

Mycal Dutta , Aninda Kumar Nath ,Md Zia Uddin , Md Akbar Hossain , Md. Masud Morshed and Md. Hassan Kawsar*

Associate Professor, Department of Pharmacy, Dhaka International University, Dhaka-1213, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1528-31

1528-1531

1275

405